Heterocyclic compounds and thrombopoietin receptor activators

ABSTRACT

A compound represented by the formula (1): 
                         
wherein A is a nitrogen atom or CR 4 , B is an oxygen atom, a sulfur atom or NR 9  (provided that when A is a nitrogen atom, B is not NH), R 1  is a C 2-14  aryl group, L 1  is a bond, CR 10 R 11 , an oxygen atom, a sulfur atom or NR 12 , X is OR 13 , SR 13  or NR 14 NR 15 , R 2  is a hydrogen atom, a formyl group, a C 1-10  alkyl group or the like, L 2  is a bond or the like, L 3  is a bond, CR 17 R 18 , an oxygen atom, a sulfur atom or NR 19 , L 4  is a bond, CR 20 R 21 , an oxygen atom, a sulfur atom or NR 22 , Y is an oxygen atom, a sulfur atom or NR 23 , and R 3  is a C 2-14  aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

This application is continuation of Ser. No. 11/837,659 filed Aug. 13,2007, now U.S. Pat. No. 7,576,115, which is a divisional of Ser. No.11/294,609 filed Dec. 6, 2005, now U.S. Pat. No. 7,351,841, which is acontinuation in part of PCT/JP2004/008165 filed on Jun. 4, 2004, andincorporated entirely herein by reference.

TECHNICAL FIELD

The present invention relates to preventive, therapeutic and improvingagents having affinity for and agonistic action on the thrombopoietinreceptor for diseases against which activation of the thrombopoietinreceptor is effective. Specifically, it relates to pharmaceuticalcompositions comprising compounds which increase platelets throughstimulation of differentiation and proliferation of hematopoietic stemcells, megakaryocytic progenitor cells and megakaryocytes or compoundsfor therapeutic angiogenesis or with anti-arteriosclerosis action thatstimulate differentiation and proliferation of vascular endothelialcells and endothelial progenitor cells.

BACKGROUND ART

Thrombopoietin is a cytokine consisting of 332 amino acids thatincreases platelet production by stimulating differentiation andproliferation of hematopoietic stem cells, megakaryocytic progenitorcells and megakaryocytes mediated by its receptor and therefore ispromising as a drug for hematological disorders. Recent reports thatstimulates differentiation and proliferation of vascular endothelialcells and endothelial progenitor cells have raised expectations oftherapeutic angiogenesis, anti-arteriosclerosis and prevention ofcardiovascular events (for example, non-patent document 1, non-patentdocument 2 and non-patent document 3).

Biologically active substances which have been known so far to regulateplatelet production through the thrombopoietin receptor include, inaddition to thrombopoietin itself, low molecular weight peptides havingaffinity for the thrombopoietin receptor (for example, patent document1, patent document 2, patent document 3 and patent document 4).

As a result of search for nonpeptidic low molecular weight compoundsthat increase platelet production mediated by the thrombopoietinreceptor, low molecular weight compounds having affinity for thethrombopoietin receptor have been reported (for example, patent document5 to patent document 24).

1) Applications filed by Hokuriku Seiyaku Co., Ltd. relating to1,4-benzodiazepine derivatives (patent documents 5 and 6)

2) International Laid-open Patent Applications filed by Shionogi & Co.,Ltd. (patent documents 7-10)

3) International Laid-open Patent Applications filed by SmithKlineBeecham Corp (patent documents 11-19)

4) Japanese Laid-open Patent Application filed by Torii PharmaceuticalCo., Ltd. (patent document 20)

5) International Laid-open Patent Application filed by Roche DiagnosticsGMBH (patent document 21)

6) International Laid-open Patent Application filed by YamanouchiPharmaceutical Co., Ltd. (patent document 22 and 23)

7) Japanese Laid-open Patent Application filed by Japan Tabacco Inc.(Patent document 24)

Patent document 1 JP-A-10-72492

Patent document 2 WO96/40750

Patent document 3 WO96/40189

Patent document 4 WO98/25965

Patent document 5 JP-A-11-1477

Patent document 6 JP-A-11-152276

Patent document 7 WO01/07423

Patent document 8 WO01/53267

Patent document 9 WO02/059099

Patent document 10 WO02/059100

Patent document 11 WO00/35446

Patent document 12 WO00/66112

Patent document 13 WO01/34585

Patent document 14 WO01/17349

Patent document 15 WO01/39773

Patent document 16 WO01/21180

Patent document 17 WO01/89457

Patent document 18 WO02/49413

Patent document 19 WO02/085343

Patent document 20 JP-A-2001-97948

Patent document 21 WO99/11262

Patent document 22 WO02/062775

Patent document 23 WO03/062233

Patent document 24 JP-A-2003-238565

Non-patent document 1 Microvasc. Res., 1999: 58, p. 108-113

Non-patent document 2 Circ. Res., 1999: 84, p. 785-796

Non-patent document 3 Blood 2001:98, p. 71a-72a

DISCLOSURE OF THE INVENTION

Thrombopoietin and low molecular weight peptides having affinity for thethrombopoietin receptor are likely to be easily degraded in thegastrointestinal tract and are usually difficult to orally, administer.As to thrombopoietin itself, the appearance of anti thrombopoietinantibodies have been reported.

Besides, though it is probably possible to orally administer nonpeptidiclow molecular weight compounds, no practical drugs have been put on themarket.

Therefore, orally administrable low molecular weight compounds havingexcellent affinity for and agonistic action on the thrombopoietinreceptor as preventive, therapeutic and improving agents for diseasesagainst which activation of the thrombopoietin receptor is effectivehave been demanded. Specifically, low molecular weight compounds whichcan serve as platelet increasing agents or increasing agents for otherblood cells by stimulating differentiation and proliferation ofhematopoietic stem cells, megakaryocytic progenitor cells andmegakaryocytes or low molecular weight compounds which can be used fortherapeutic angiogenesis or as preventive and therapeutic agents forarteriosclerosis by stimulating endothelial cells and endothelialprogenitor cells have been demanded.

The present inventors conducted extensive research to find low molecularweight compounds having affinity for and agonistic action on thethrombopoietin receptor, and as a result, found that the compounds ofthe present invention have high affinity and agonistic action whichenable them to show potent platelet increasing action by stimulatingdifferentiation and proliferation of megakaryocytic progenitor cells andmegakaryocytes. The present invention was accomplished on the basis ofthis discovery.

Namely, the present invention relates to:

1. A compound represented by the formula (1)

wherein A is a nitrogen atom or CR⁴ (wherein R⁴ is a hydrogen atom, ahydroxyl group (the hydroxyl group may be substituted with a C₂₋₆alkenyl group or a C₂₋₆ alkynyl group), a thiol group (the thiol groupmay be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), an amino group (theamino group may be substituted with one or two C₂₋₆ alkenyl groups orone or two C₂₋₆ alkynyl groups), a formyl group, a halogen atom, a nitrogroup, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and theC₁₋₁₀ alkoxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), a C₂₋₁₄aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: aC₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may be substituted with one ormore halogen atoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group,an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group,a protected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxygroup), SO₂R⁵, SOR⁵ or COR⁵ (wherein R⁵ is a hydroxyl group, a C₁₋₁₀alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxygroup (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynylgroup and the C₁₋₁₀ alkoxy group may be optionally substituted with oneor more substituents selected from the group consisting of: a carboxylgroup, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxygroup, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an aminogroup, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₂₄ aryl group and a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substitutedwith one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxygroup may be optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀alkyl group may be substituted with one or more halogen atoms), a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group) or NR⁶R⁷ (wherein each of R⁶ andR⁷ is independently a hydrogen atom, a hydroxyl group, a formyl group, aC₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, C₁₋₁₀ alkylcarbonylamino group, an amino group, amono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), or R⁶ andR⁷ mean, together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein Eis an oxygen atom, a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ arylgroup, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group ora protected hydroxyl group) or NR⁸ (wherein R⁸ is a hydrogen atom, ahydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group,C₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (theC₁₋₆ alkyl group may be substituted with one or more halogen atoms) orone or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl groupmay be substituted with one or more halogen atoms), a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group)), and each of m1 and m2 isindependently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or5)))),

B is an oxygen atom, a sulfur atom or NR⁹ (wherein R⁹ is a hydrogenatom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (theC₁₋₆ alkyl group may be substituted with one or more halogen atoms) orone or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl groupmay be substituted with one or more halogen atoms), a C₂₋₆ alkenylgroup, C₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₂₋₁₀ alkylcarbonyloxy group, a alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group) or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxygroup may be optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀alkyl group may be substituted with one or more halogen atoms), a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group)) (provided that when A is anitrogen atom, B is not NH),

R¹ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be substituted withone or more substituents selected from the group consisting of: ahalogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, ahydroxyl group, a protected hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonylgroup, the C₁₋₁₀ alkylcarbonyloxy group and the C₁₋₁₀ alkoxycarbonylgroup may be optionally substituted with one or more substituentsselected from the group consisting of: a carboxyl group, a nitro group,a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), a thiolgroup and an amino group (the thiol group and the amino group may beoptionally substituted with one or two substituents selected from thegroup consisting of: a formyl group, a C₁₋₂₀ alkyl group, a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group and a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and theC₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₂₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore. C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted withone or more halogen atoms) or one or more halogen atoms)))),

L¹ is a bond, CR¹⁰R¹¹ (wherein each of R¹⁰ and R¹¹ is independently ahydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms)), an oxygen atom, a sulfuratom or NR¹² (wherein R¹² is a hydrogen atom, a hydroxyl group, a formylgroup, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group,a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkylgroup, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxygroup, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl groupand the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with oneor more substituents selected from the group consisting of: a carboxylgroup, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxygroup, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an aminogroup, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substitutedwith one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group)),

X is OR¹³, SR¹³ or NR¹⁴R¹⁵ (wherein R¹³ is a hydrogen atom, a C₁₋₁₀alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group or a C₂₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group and the C₁₋₁₀ alkylcarbonyl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a carboxyl group, a nitro group, a cyano group, a halogenatom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxygroup may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆alkyl group may be substituted with one or more halogen atoms) or one ormore halogen atoms)), and each of R¹⁴ and R¹⁵ is independently ahydrogen atom, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynylgroup, the C₁₋₁₀ alkoxy group and the C₁₋₁₀ alkylcarbonyl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxygroup may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆alkyl group may be substituted with one or more halogen atoms) or one ormore halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₂₄ aryl groupand a C₂₋₁₄ aryloxy group)),

R² is a hydrogen atom, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group,the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkoxycarbonylgroup, the C₁₋₁₀ alkylcarbonyloxy group and the C₁₋₁₀ alkylcarbonylgroup may be optionally substituted with one or more substituentsselected from the group consisting of: a carboxyl group, a nitro group,a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group),

L² is a bond, CR³⁴R³⁵ (wherein each of R³⁴ and R³⁵ is independently ahydrogen atom or a C₁₋₆ alkyl group (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms)), an oxygen atom, a sulfuratom or NR¹⁶ (wherein R¹⁶ is a hydrogen atom, a hydroxyl group, a formylgroup, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group,a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkylgroup, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxygroup, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl groupand the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with oneor more substituents selected from the group consisting of: a carboxylgroup, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxygroup, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an aminogroup, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substitutedwith one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aalkylcarbonylamino group, an amino group, a mono- or alkylamino group, ahydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl group and aC₂₋₁₄ aryloxy group)),

L³ is a bond, CR¹⁷R¹⁸ (wherein each of R¹⁷ and R¹⁸ is independently ahydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynylgroup, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀alkoxy group and the C₁₋₁₀ alkylcarbonyl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a carboxyl group, a nitro group, a cyano group, a halogenatom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxygroup may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆alkyl group may be substituted with one or more halogen atoms) or one ormore halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₃₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group)), an oxygen atom, a sulfur atom or NR¹⁹(wherein R¹⁹ is a hydrogen atom, a hydroxyl group, a formyl group, aC₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group,the C₁₋₁₀ alkoxycarbonyl group, the C₁₋₃₀ alkoxy group and the C₁₋₁₀alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, a hydroxylgroup, a protected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may besubstituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group maybe substituted with one or more halogen atoms) or one or more halogenatoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino is group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group)),

L⁴ is a bond, CR²⁰R²¹ (wherein each of R²⁰ and R²¹ is independently ahydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynylgroup, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀alkoxy group and the C₁₋₁₀ alkylcarbonyl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a carboxyl group, a nitro group, a cyano group, a halogenatom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxygroup may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆alkyl group may be substituted with one or more halogen atoms) or one ormore halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group)), an oxygen atom, a sulfur atom or NR²²(wherein R²² is a hydrogen atom, a hydroxyl group, a formyl group, aC₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aalkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group)),

Y is an oxygen atom, a sulfur atom or NR²³ (wherein R²³ is a hydrogenatom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (theC₁₋₆ alkyl group may be substituted with one or more halogen atoms) orone or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl groupmay be substituted with one or more substituents selected from the groupconsisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group)), and

R³ is a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be substituted withone or more substituents independently represented by —W¹(CW²W³)_(m)W⁴(wherein W¹ is (CR²⁴R²⁵)_(n) (wherein each of R²⁴ and R²⁵ isindependently a hydrogen atom or a C₁₋₆ alkyl group, (the C₁₋₆ alkylgroup may be substituted with one or more halogen atoms), and n is 0, 1,2 or 3), an oxygen atom, a sulfur atom or NR³⁶ (wherein R³⁶ is ahydrogen atom, a C₁₋₆ alkyl group, a formyl group or a C₁₋₆alkylcarbonyl group), each of W² and W³ is independently a hydrogen atomor a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may be substituted with oneor more halogen atoms), m is 0, 1, 2 or and W⁴ is a hydroxyl group, athiol group, an amino group, a formyl group, a halogen atom, a nitrogroup, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group(the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group,the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkylcarbonylamino group and the mono- or di-C₁₋₁₀ alkylamino group maybe optionally substituted with one or more substituents selected fromthe group consisting of: a carboxyl group, a nitro, group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, a amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (theC₁₋₆ alkyl group may be substituted with one or more halogen atoms) orone or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl groupmay be substituted with one or more halogen atoms), a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a thiolgroup, a phosphonic acid group, a sulfonic acid group, a tetrazolegroup, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), SO₂R²⁸, SOR²⁸,COR²⁸ (wherein R²⁸ is a hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and theC₁₋₁₀ alkoxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, C₁₋₁₀ alkylcarbonylamino group, an amino group, amono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup, a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxygroup may be optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀alkyl group may be substituted with one or more halogen atoms), a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group) or NR²⁹R³⁰ (wherein each of R²⁹and R³⁰ is independently a hydrogen atom, a hydroxyl group, a formylgroup, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkylgroup, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxygroup, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl groupand the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with oneor more substituents selected from the group consisting of: a carboxylgroup, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxygroup, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an aminogroup, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substitutedwith one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group), or R²⁹ and R³⁰, together with each othermeans —(CH₂)_(m3)-G-(CH₂)_(m4)— (wherein G is an oxygen atom, sulfuratom, a CR³¹R³² (wherein each of R³¹ and R³² is independently a hydrogenatom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxy group, aC₂₋₁₄ aryloxy group, a hydroxyl group or a protected hydroxyl group) orNR³³ (wherein R³³ is a hydrogen atom, a hydroxyl group, a formyl group,a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, C₂₋₆ alkynyl group, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-CO₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group)), and eachof m3 and m4 is independently an integer of from 0 to 5, provided thatm3+m4 is 3, 4 or 5))), a tetrazole group, or a phosphonic acid group)),a tautomer, prodrug or pharmaceutically acceptable salt of the compoundor a solvate thereof.

2. The compound according to 1, wherein A is a nitrogen atom, and B is asulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt ofthe compound or a solvate thereof.

3. The compound according to 1, wherein A is a nitrogen atom, and B isan oxygen atom, a tautomer, prodrug or pharmaceutically acceptable saltof the compound or a solvate thereof.

4. The compound according to 1, wherein A is a nitrogen atom, and B isNR⁹ (wherein R⁹ is a hydroxyl group, a formyl group, a C₁₋₁₀ alkylgroup, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group,a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxygroup may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ isalkyl group may be substituted with one or more halogen atoms) or one ormore halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group) or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxygroup may be optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀alkyl group may be substituted with one or more halogen atoms), a C₂₋₆alkenyl, group, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group)), a tautomer, prodrug orpharmaceutically acceptable salt of the compound or a solvate thereof.5. The compound according to 1, wherein A is CR⁴ (wherein R⁴ is ahydrogen atom, a hydroxyl group (the hydroxyl group may be substitutedwith a C₂₋₆ alkenyl or a C₂₋₆ alkynyl group), a thiol group (the thiolgroup may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group,a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), an amino group(the amino group may be substituted with one or two C₂₋₆ alkenyl groupsor one or two C₂₋₆ alkynyl groups), a formyl group, a halogen atom, anitro group, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and theC₁₋₁₀ alkoxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), a C₂₋₁₄aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: aC₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may be substituted with one ormore halogen atoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group,an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group,a protected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxygroup), SO₂R⁵, SOR⁵ or COR⁵ (wherein R⁵ is a hydroxyl group, a C₁₋₁₀alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxygroup (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynylgroup and the C₁₋₁₀ alkoxy group may be optionally substituted with oneor more substituents selected from the group consisting of: a carboxylgroup, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxygroup, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₂₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an aminogroup, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substitutedwith one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxygroup may be optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀alkyl group may be substituted with one or more halogen atoms), a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group) or NR⁶R⁷ (wherein each of R⁶ andR⁷ is independently a hydrogen atom, a hydroxyl group, a formyl group, aC₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₂₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), or R⁶ andR⁷ mean, together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein Eis an oxygen atom, a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷is independently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ arylgroup, a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group ora protected hydroxyl group) or NR⁸ (wherein R⁸ is a hydrogen atom, ahydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenylgroup, C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₃₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₂₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (theC₁₋₆ alkyl group may be substituted with one or more halogen atoms) orone or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl groupmay be substituted with one or more halogen atoms), a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group)), and each of m1 and m2 isindependently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or5)))), and B is a oxygen atom, a tautomer, prodrug or pharmaceuticallyacceptable salt of the compound or a solvate thereof.6. The compound according to 1, wherein A is CR⁴ (wherein R⁴ is ahydrogen atom, a hydroxyl group (the hydroxyl group may be substitutedwith a C₂₋₆ alkenyl or a C₂₋₆ alkynyl group), a thiol group (the thiolgroup may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group,a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), an amino group(the amino group may be substituted with one or two C₂₋₆ alkenyl groupsor one or two C₂₋₆ alkynyl groups), a formyl group, a halogen atom, anitro group, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and theC₁₋₁₀ alkoxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl is groups (the C₁₋₆ alkyl group may be substituted withone or more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), a C₂₋₁₄aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: aC₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may be substituted with one ormore halogen atoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group,an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group,a protected hydroxyl group, C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group),SO₂R⁵, SOR⁵ or COR⁵ (wherein R⁵ is a hydroxyl group, a C₁₋₁₀ alkylgroup, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group(the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl groupand the C₁₋₁₀ alkoxy group may be optionally substituted with one ormore substituents selected from the group consisting of: a carboxylgroup, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxygroup, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group; an aminogroup, a mono- or alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₂₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), a C₂₋₁₄aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: aC₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may be substituted with one ormore halogen atoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group,an amino group, a mono or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group)or NR⁶R⁷ (wherein each of R⁶ and R⁷ is independently a hydrogen atom, ahydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (theC₁₋₆ alkyl group may be substituted with one or more halogen atoms) orone or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl groupmay be substituted with one or more halogen atoms), a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group), or R⁶ and R⁷ mean, together witheach other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein E is an oxygen atom, asulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ is independently ahydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxygroup, a C₂₋₁₄ aryloxy group, hydroxyl group or a protected hydroxylgroup) or NR⁸ (wherein R⁸ is a hydrogen atom, a hydroxyl group, formylgroup, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group,a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group,the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group,the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and theC₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a alkylcarbonylamino group, an amino group, amono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group)), and eachof m1 and m2 is independently an integer of from 0 to 5 provided thatm1+m2 is 3, 4 or 5)))), and B is a sulfur atom, a tautomer, prodrug orpharmaceutically acceptable salt of the compound or a solvate thereof.7. The compound according to 1, wherein A is CR⁴ (wherein R⁴ is ahydrogen atom, a hydroxyl group (the hydroxyl group may be substitutedwith a C₂₋₆ alkenyl or a C₂₋₆ alkynyl group), a thiol group (the thiolgroup may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group,a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), an amino group(the amino group may be substituted with one or two C₂₋₆ alkenyl groupsor one or two C₂₋₆ alkynyl groups), a formyl group, a halogen atom, anitro group, cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, a C₁₋₁₀alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and theC₁₋₁₀ alkoxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), a C₂₋₁₄aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: aC₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may be substituted with one ormore halogen atoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, a alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, anamino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group),SO₂R⁵, SOR⁵ or COR⁵ (wherein R⁵ is a hydroxyl group, a C₁₋₁₀ alkylgroup, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group(the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl groupand the C₁₋₁₀ alkoxy group may be optionally substituted with one ormore substituents selected from the group consisting of: a carboxylgroup, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxygroup, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an aminogroup, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substitutedwith one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxygroup may be optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀alkyl group may be substituted with one or more halogen atoms), a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group) or NR⁶R⁷ (wherein each of R⁶ andR⁷ is independently a hydrogen atom, a hydroxyl group, a formyl group, aC₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C_(1-n) alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, alkylcarbonylamino group, an amino group, a mono-or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protected hydroxylgroup, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), or R⁶ and R⁷ mean,together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein E is anoxygen atom, a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ isindependently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group,a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group or aprotected hydroxyl group) or NR⁸ (wherein R⁸ is a hydrogen atom, ahydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (theC₁₋₆ alkyl group may be substituted with one or more halogen atoms) orone or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl groupmay be substituted with one or more halogen atoms), a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a carboxyl, group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group,C₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group)), and each of m1 and m2 isindependently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or5)))), and

B is NR⁹ (wherein R⁹ is a hydrogen atom, a hydroxyl group, a formylgroup, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group,a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkylgroup, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxygroup, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl groupand the C₁₋₁₀ alkylcarbonyl group may be optionally substituted with oneor more substituents selected from the group consisting of: a carboxylgroup, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxygroup, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an aminogroup, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substitutedwith one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy is group, a C₁₋₁₀ alkylcarbonyl group, aC₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aalkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group) or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxygroup may be optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀alkyl group may be substituted with one or more halogen atoms), a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group)), a tautomer, prodrug orpharmaceutically acceptable salt of the compound or a solvate thereof.

8. The compound according to 1, wherein L¹ is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

9. The compound according to 2, wherein L¹ is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

10. The compound according to 3, wherein L¹ is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

11. The compound according to 4, wherein L¹ is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

12. The compound according to 5, wherein L¹ is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

13. The compound according to 6, wherein L¹ is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

14. The compound according to 7, wherein L¹ is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

15. The compound according to 1, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

16. The compound according to 2, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

17. The compound according to 3, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

18. The compound according to 4, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

19. The compound according to 5, wherein L² is a bond, tautomer, prodrugor pharmaceutically acceptable salt of is the compound or a solvatethereof.

20. The compound according to 6, wherein L² is a bond, tautomer, prodrugor pharmaceutically acceptable salt of the compound or a solvatethereof.

21. The compound according to 7, wherein L² is a bond, tautomer, prodrugor pharmaceutically acceptable salt of the compound or a solvatethereof.

22. The compound according to 8, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

23. The compound according to 9, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

24. The compound according to 10, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

25. The compound according to 11, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

26. The compound according to 12, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

27. The compound according to 13, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

28. The compound according to 14, wherein L² is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.

29. The compound according to 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13,14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 or 28, wherein L³is NR¹⁹ (wherein R¹⁹ is a hydrogen atom, a hydroxyl group, a formylgroup, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group,a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkylgroup, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group, the C₁₋₁₀ alkoxygroup and the C₁₋₁₀ alkylcarbonyl group may be optionally substitutedwith one or more substituents selected from the group consisting of: acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₂₀ alkylcarbonyloxygroup, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group,an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group,a protected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substitutedwith one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group)), a tautomer, prodrug or pharmaceuticallyacceptable salt of the compound or a solvate thereof.30. The compound according to 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13,14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 or 28, wherein L³is NH, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.31. The compound according to 29, wherein L⁴ is NR²² (wherein R²² is ahydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, aC₂₋₆ alkenyl group, C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group,C₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxygroup may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆alkyl group may be substituted with one or more halogen atoms) or one ormore halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group)), a tautomer, prodrug or pharmaceuticallyacceptable salt of the compound or a solvate thereof.32. The compound according to 30, wherein L⁴ is the same as defined in31, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.33. The compound according to 29, wherein L⁴ is NH, tautomer, prodrug orpharmaceutically acceptable salt of the compound or a solvate thereof.34. The compound according to 30, wherein L⁴ is NH, a tautomer, prodrugor pharmaceutically acceptable salt of the compound or a solvatethereof.35. The compound according to 29, wherein L⁴ is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.36. The compound according to 30, wherein L⁴ is a bond, a tautomer,prodrug or pharmaceutically acceptable salt of the compound or a solvatethereof.37. The compound according to 31, wherein Y is an oxygen atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.38. The compound according to 32, wherein Y is an oxygen atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.39. The compound according to 33, wherein Y is an oxygen atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.40. The compound according to 34, wherein Y is an oxygen atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.41. The compound according to 35, wherein Y is an oxygen atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.42. The compound according to 36, wherein Y is an oxygen atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.43. The compound according to 31, wherein Y is a sulfur atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.44. The compound according to 32, wherein Y is a sulfur atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.45. The compound according to 33, wherein Y is a sulfur atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.46. The compound according to 34, wherein Y is a sulfur atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.47. The compound according to 35, wherein Y is a sulfur atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.48. The compound according to 36, wherein Y is a sulfur atom, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.49. The compound according to 37, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.50. The compound according to 38, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.51. The compound according to 39, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.52. The compound according to 40, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.53. The compound according to 41, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.54. The compound according to 42, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.55. The compound according to 43, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.56. The compound according to 44, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.57. The compound according to 45, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.58. The compound according to 46, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.59. The compound according to 47, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.60. The compound according to 48, wherein X is a hydroxyl group, atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.61. The compound according to 37, wherein R³ is a C₂₋₁₄ aryl group (theC₂₋₁₄ aryl group is optionally substituted with one or more substituentsselected from the group consisting of: a hydroxyl group, an amino group,a carboxyl group, a phosphonic acid group, a sulfonic acid group, acarbamido group, a sulfamido group, a tetrazole group and a C₁₋₁₀alkoxycarbonyl group), a tautomer, prodrug or pharmaceuticallyacceptable salt of the compound or a solvate thereof.62. The compound according to 38, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.63. The compound according to 39, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.64. The compound according to 40, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.65. The compound according to 41, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.66. The compound according to 42, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.67. The compound according to 49, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.68. The compound according to 50, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.69. The compound according to 51, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.70. The compound according to 52, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.71. The compound according to 53, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.72. The compound according to 54, wherein R³ is the same as defined in61, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.73. The compound according to 43, wherein R³ is a C₂₋₁₄ aryl group (theC₂₋₁₄ aryl group is optionally substituted with one or more substituentsselected from the group consisting of: a hydroxyl group, an amino group,a carboxyl group, a phosphonic acid group, a sulfonic acid group, acarbamido group, a sulfamido group, a tetrazole group and a C₁₋₁₀alkoxycarbonyl group), a tautomer, prodrug or pharmaceuticallyacceptable salt of the compound or a solvate thereof.74. The compound according to 44, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically is acceptable salt of thecompound or a solvate thereof.75. The compound according to 45, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.76. The compound according to 46, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.77. The compound according to 47, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.78. The compound according to 48, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.79. The compound according to 55, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.80. The compound according to 56, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.81. The compound according to 57, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.82. The compound according to 58, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.83. The compound according to 59, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.84. The compound according to 60, wherein R³ is the same as defined in73, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.85. The compound according to 37, wherein R³ is a C₂₋₁₄ aryl group (theC₂₋₁₄ aryl group is optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkylcarbonylamino group and a mono- or di-C₁₋₁₀ alkylamino group), atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.86. The compound according to 38, wherein R³ is the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.87. The compound according to 39, wherein R³ is the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.88. The compound according to 40, wherein R³ is, the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.89. The compound according to 41, wherein R³ is the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.90. The compound according to 42, wherein R³ is the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.91. The compound according to 49, wherein R³ is the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.92. The compound according to 50, wherein R³ is the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.93. The compound according to 51, wherein R³ is the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.94. The compound according to 52, wherein R³ is the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.95. The compound according to 53, wherein R³ is the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.96. The compound according to 54, wherein R³ is the same as defined in85, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.97. The compound according to 43, wherein R³ is a C₂₋₁₄ aryl group (theC₂₋₂₄ aryl group is optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkylcarbonylamino group and a mono- or di-C₁₋₁₀ alkylamino group), atautomer, prodrug or pharmaceutically acceptable salt of the compound ora solvate thereof.98. The compound according to 44, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.99. The compound according to 45, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.100. The compound according to 46, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.101. The compound according to 47, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.102. The compound according to 48, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.103. The compound according to 55, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.104. The compound according to 56, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.105. The compound according to 57, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.106. The compound according to 58, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.107. The compound according to 59, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.108. The compound according to 60, wherein R³ is the same as defined in97, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.109. The compound according to 37, wherein R³ is a C₂₋₁₄ aryl group (theC₂₋₁₄ aryl group is optionally substituted with one or more substituentsselected from the group consisting of:

a hydroxyl group, an amino group, a carboxyl group, a phosphonic acidgroup, a sulfonic acid group, carbamido group, a sulfamido group, atetrazole group and a alkoxycarbonyl group

and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C₂₋₁₀ alkyl groupsubstituted with one or more fluorine atoms, a sulfamido groupsubstituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group), a tautomer, prodrug or pharmaceuticallyacceptable salt of the compound or a solvate thereof.

110. The compound according to 38, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

111. The compound according to 39, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

112. The compound according to 40, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

113. The compound according to 41, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

114. The compound according to 42, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

115. The compound according to 49, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

116. The compound according to 50, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

117. The compound according to 51, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

118. The compound according to 52, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

119. The compound according to 53, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

120. The compound according to 54, wherein R³ is the same as defined in109, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

121. The compound according to 43, wherein R³ is a C₂₋₁₄ aryl group (theC₂₋₁₄ aryl group is optionally substituted with one or more substituentsselected from the group consisting of:

a hydroxyl group, an amino group, a carboxyl group, a phosphonic acidgroup, a sulfonic acid group, a carbamido group, a sulfamido group, atetrazole group and a C₁₋₁₀ alkoxycarbonyl group

and one or more substituents selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkyl groupsubstituted with one or more fluorine atoms, a sulfamido groupsubstituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group), tautomer, prodrug or pharmaceuticallyacceptable salt of the compound or a solvate thereof.

122. The compound according to 44, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

123. The compound according to 45, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

124. The compound according to 46, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

125. The compound according to 47, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

126. The compound according to 48, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

127. The compound according to 55, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

128. The compound according to 56, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

129. The compound according to 57, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

130. The compound according to 58, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

131. The compound according to 59, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

132. The compound according to 60, wherein R³ is the same as defined in121, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof.

133. The thrombopoietin receptor activator according to 1.

134. The thrombopoietin receptor activator according to 2.

135. The thrombopoietin receptor activator according to 3.

136. The thrombopoietin receptor activator according to 4.

137. The thrombopoietin receptor activator according to 5.

138. The thrombopoietin receptor activator according to 6.

139. The thrombopoietin receptor activator according to 7.

140. The thrombopoietin receptor activator according to any one of 8 to14.

141. The thrombopoietin receptor activator according to any one of 15 to28.

142. The thrombopoietin receptor activator according to 29.

143. The thrombopoietin receptor activator according to 30.

144. The thrombopoietin receptor activator according to 31 or 32.

145. The thrombopoietin receptor activator according to 33 or 34.

146. The thrombopoietin receptor activator according to 35 or 36.

147. The thrombopoietin receptor activator according to any one of 37 to42.

148. The thrombopoietin receptor activator according to any one of 43 to48.

149. The thrombopoietin receptor activator according to any one of 49 to54.

150. The thrombopoietin receptor activator according to any one of 55 to60.

151. The thrombopoietin receptor activator according to any one of 61 to72.

152. The thrombopoietin receptor activator according to any one of 73 to84.

153. The thrombopoietin receptor activator according to any one of 85 to96.

154. The thrombopoietin receptor activator according to any one of 97 to108.

155. The thrombopoietin receptor activator according to any one of 109to 120.

156. The thrombopoietin receptor activator according to any one of 121to 132.

157. A preventive, therapeutic or improving agent for diseases againstwhich activation of the thrombopoietin receptor is effective, whichcontains the thrombopoietin receptor activator according to any one of133 to 156, a tautomer, prodrug or pharmaceutically acceptable salt ofthe activator or a solvate thereof, as an active ingredient.158. A platelet increasing agent containing the thrombopoietin receptoractivator according to any one of 133 to 156, a tautomer, prodrug orpharmaceutically acceptable salt of the activator or a solvate thereof,as an active ingredient.159. Medicament containing the compound according to any one of 1 to132, a tautomer, prodrug or pharmaceutically acceptable salt of thecompound or a solvate thereof, as an active ingredient.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the proliferation of UT7/EPO-mpl cells when stimulated bythe compound of the present invention (Synthetic Example 3).

FIG. 2 shows the proliferation of UT7/EPO cells when stimulated by thecompound of the present invention (Synthetic Example 3).

BEST MODE FOR CARRYING OUT THE INVENTION

Now, the present invention will be described in detail.

In the present invention, “n” denotes normal, “i” denotes iso, “s”denotes secondary, “t” denotes tertiary, “c” denotes cyclo, “o” denotesortho, “m” denotes meta, “p” denotes para, “Ph” denotes phenyl, “Py”denotes pyridyl, “Ac” denotes acetyl, “Naphthyl” denotes naphthyl, “Me”denotes methyl, “Et” denotes ethyl, “Pr” denotes propyl, and “Bu”denotes butyl.

First, the terms in the respective substituents R¹ to R³⁶ will beexplained.

As a halogen atom, a fluorine atom, a chlorine atom, a bromine atom oran iodine atom may be mentioned.

A C₁₋₃ alkyl group may be linear, branched or a C₃ cycloalkyl group, andmethyl, ethyl, n-propyl, i-propyl and c-propyl and the like may bementioned.

A C₁₋₆ alkyl group may be linear, branched or a C₃₋₆ cycloalkyl group,and in addition to those mentioned above, n-butyl, i-butyl, s-butyl,t-butyl, c-butyl, 1-methyl-c-propyl, 2-methyl-c-propyl, n-pentyl,1-methyl-n-butyl, 2-methyl-n-butyl, 3-methyl-n-butyl,1,1-dimethyl-n-propyl, 1,2-dimethyl-n-propyl, 2,2-dimethyl-n-propyl,1-ethyl-n-propyl, c-pentyl, 1-methyl-c-butyl, 2-methyl-c-butyl,3-methyl-c-butyl, 1,2-dimethyl-c-propyl, 2,3-dimethyl-c-propyl,1-ethyl-c-propyl, 2-ethyl-c-propyl, n-hexyl, 1-methyl-n-pentyl,2-methyl-n-pentyl, 3-methyl-n-pentyl, 4-methyl-n-pentyl,1,1-dimethyl-n-butyl, 1,2-dimethyl-n-butyl, 1,3-dimethyl-n-butyl,2,2-dimethyl-n-butyl, 2,3-dimethyl-n-butyl, 3,3-dimethyl-n-butyl,1-ethyl-n-butyl, 2-ethyl-n-butyl, 1,1,2-trimethyl-n-propyl,1,2,2-trimethyl-n-propyl, 1-ethyl-1-methyl-n-propyl,1-ethyl-2-methyl-n-propyl, c-hexyl, 1-methyl-c-pentyl,2-methyl-c-pentyl, 3-methyl-c-pentyl, 1-ethyl-c-butyl, 2-ethyl-c-butyl,3-ethyl-c-butyl, 1,2-dimethyl-c-butyl, 1,3-dimethyl-c-butyl,2,2-dimethyl-c-butyl, 2,3-dimethyl-c-butyl, 2,4-dimethyl-c-butyl,3,3-dimethyl-c-butyl, 1-n-propyl-c-propyl, 2-n-propyl-c-propyl,1-i-propyl-c-propyl, 2-i-propyl-c-propyl, 1,2,2-trimethyl-c-propyl,1,2,3-trimethyl-c-propyl, 2,2,3-trimethyl-c-propyl,1-ethyl-2-methyl-c-propyl, 2-ethyl-1-methyl-c-propyl,2-ethyl-2-methyl-c-propyl, 2-ethyl-3-methyl-c-propyl and the like may bementioned.

A C₁₋₁₀ alkyl group may be linear, branched or a C₃₋₁₀ cycloalkyl group,and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentyl,1-heptyl, 2-heptyl, 1-ethyl-1,2-dimethyl-n-propyl,1-ethyl-2,2-dimethyl-n-propyl, 1-octyl, 3-octyl, 4-methyl-3-n-heptyl,6-methyl-2-n-heptyl, 2-propyl-1-n-heptyl, 2,4,4-trimethyl-1-n-pentyl,1-nonyl, 2-nonyl, 2,6-dimethyl-4-n-heptyl,3-ethyl-2,2-dimethyl-3-n-pentyl, 3,5,5-trimethyl-1-n-hexyl, 1-decyl,2-decyl, 4-decyl, 3,7-dimethyl-1-n-octyl, 3,7-dimethyl-3-n-octyl and thelike may be mentioned.

As a C₂₋₆ alkynyl group, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl,2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl,3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl,2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl,2-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl,5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl,1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl,3-methyl-1-pentynyl, 3-methyl-4-pentynyl, 4-methyl-1-pentynyl,4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl,1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-sbutynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 1-n-propyl-2-propynyl,2-ethyl-3-butynyl, 1-methyl-1-ethyl-2-propynyl, 1-i-propyl-2-propynyland the like may be mentioned.

A C₂₋₆ alkenyl group may be linear, branched or a C₃₋₆ cycloalkenylgroup, and ethenyl, 1-propenyl, 2-propenyl, 1-methyl-1-ethenyl,1-butenyl, 2-butenyl, 3-butenyl, 2-methyl-1-propenyl,2-methyl-2-propenyl, 1-ethylethenyl, 1-methyl-1-propenyl,1-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl,1-n-propylethenyl, 1-methyl-1-butenyl, 1-methyl-2-butenyl,1-methyl-3-butenyl, 2-ethyl-2-propenyl, 2-methyl-1-butenyl,2-methyl-2-butenyl, 2-methyl-3-butenyl, 3-methyl-1-butenyl,3-methyl-2-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl,1-i-propylethenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl,1-c-pentenyl, 2-c-pentenyl, 3-c-pentenyl, 1-hexenyl, 2-hexenyl,3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1-pentenyl,1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl,1-n-butylethenyl, 2-methyl-1-pentenyl, 2-methyl-2-pentenyl,2-methyl-3-pentenyl, 2-methyl-4-pentenyl, 2-n-propyl-2-propenyl,3-methyl-1-pentenyl, 3-methyl-2-pentenyl, 3-methyl-3-pentenyl,3-methyl-4-pentenyl, 3-ethyl-3-butenyl, 4-methyl-1-pentenyl,4-methyl-2-pentenyl, 4-methyl-3-pentenyl, 4-methyl-4-pentenyl,1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butenyl,1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl,1-methyl-2-ethyl-2-propenyl, 1-s-butylethenyl, 1,3-dimethyl-1-butenyl,1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 1-i-butylethenyl,2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl,2,3-dimethyl-3-butenyl, 2-i-propyl-2-propenyl, 3,3-dimethyl-1-butenyl,1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl,1-n-propyl-1-propenyl, 1-n-propyl-2-propenyl, 2-ethyl-1-butenyl,2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl,1-t-butylethenyl, 1-methyl-1-ethyl-2-propenyl,1-ethyl-2-methyl-1-propenyl, 1-ethyl-2-methyl-2-propenyl,1-i-propyl-1-propenyl, 1-i-propyl-2-propenyl, 1-methyl-2-c-pentenyl,1-methyl-3-c-pentenyl, 2-methyl-1-c-pentenyl, 2-methyl-2-c-pentenyl,2-methyl-3-c-pentenyl, 2-methyl-4-c-pentenyl, 2-methyl-5-c-pentenyl,2-methylene-c-pentyl, 3-methyl-1-c-pentenyl, 3-methyl-2-c-pentenyl,3-methyl-3-c-pentenyl, 3-methyl-4-c-pentenyl, 3-methyl-5-c-pentenyl,3-methylene-c-pentyl, 1-c-hexenyl, 2-c-hexenyl, 3-c-hexenyl and the likemay be mentioned.

A C₂₋₁₄ aryl group may be a C₆₋₁₄ aryl group containing no hetero atomsas ring constituting atoms or a C₂₋₉ aromatic heterocyclic group, and aC₂₋₉ aromatic heterocyclic group may be a 5 to 7-membered C₂₋₆heteromonocyclic group or 8 to 10-membered C₅₋₉ fused heterobicyclicgroup containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfuratoms singly or in combination.

As a C₆₋₁₄ aryl group containing no hetero atoms, a phenyl group, a1-indenyl group, a 2-indenyl group, a indenyl group, a 4-indenyl group,a 5-indenyl group, a 6-indenyl group, a 7-indenyl group, an α-naphthylgroup, a β-naphthyl group, a 1-tetrahydronaphthyl group, a2-tetrahydronaphthyl group, a 5-tetrahydronaphthyl group,6-tetrahydronaphthyl group, an o-biphenylyl group, a m-biphenylyl group,a p-biphenylyl group, a 1-anthryl group, a 2-anthryl group, a 9-anthrylgroup, a 1-phenanthryl group, a 2-phenanthryl group, a 3-phenanthrylgroup, a 4-phenanthryl group, a 9-phenanthryl group or the like may bementioned.

A 5 to 7-membered C₂₋₆ heteromonocyclic group may be a 2-thienyl group,a 3-thienyl group, a 2-furyl group, a 3-furyl group, a 2-pyranyl group,a 3-pyranyl group, a 4-pyranyl group, a 1-pyrrolyl group, a 2-pyrrolylgroup, a 3-pyrrolyl group, a 1-imidazolyl group, a 2-imidazolyl group, a4-imidazolyl group, a 1-pyrazolyl group, a 3-pyrazolyl group, a4-pyrazolyl group, a 2-thiazolyl group, a 4-thiazolyl group, a5-thiazolyl group, a 3-isothiazolyl group, a 4-isothiazolyl group, a5-isothiazolyl group, a 2-oxazolyl group, a 4-oxazolyl group, a5-oxazolyl group, a 3-isoxazolyl group, a 4-isoxazolyl group, a5-isoxazolyl group, a 2-pyridyl group, a 3-pyridyl group, a 4-pyridylgroup, a 2-pyrazinyl group, a 2-pyrimidinyl group, a 4-pyrimidinylgroup, a 5-pyrimidinyl group, a 3-pyridazinyl group, a 4-pyridazinylgroup, a 2-1,3,4-oxadiazolyl group, a 2-1,3,4-thiadiazolyl group, a3-1,2,4-oxadiazolyl group, a 5-1,2,4-oxadiazolyl group, a3-1,2,4-thiadiazolyl group, a 5-1,2,4-thiadiazolyl group, a3-1,2,5-oxadiazolyl group, a 3-1,2,5-thiadiazolyl group or the like.

A 8 to 10-membered C₅₋₉ fused heterocyclic group may be a 2-benzofuranylgroup, a 3-benzofuranyl group, a 4-benzofuranyl group, a 5-benzofuranylgroup, a 6-benzofuranyl group, a 7-benzofuranyl group, a1-isobenzofuranyl group, a 4-isobenzofuranyl group, a 5-isobenzofuranylgroup, a 2-benzothienyl group, a 3-benzothienyl group, a 4-benzothienylgroup, a 5-benzothienyl group, a 6-benzothienyl group, a 7-benzothienylgroup, a 1-isobenzothienyl group, a 4-isobenzothienyl group, a5-isobenzothienyl group, a 2-chromenyl group, a 3-chromenyl group, a4-chromenyl group, a 5-chromenyl group, a 6-chromenyl group, a7-chromenyl group, a 8-chromenyl group, a 1-indolizinyl group, a2-indolizinyl group, a 3-indolizinyl group, a 5-indolizinyl group, a6-indolizinyl group, a 7-indolizinyl group, a 8-indolizinyl group, a1-isoindolyl group, a 2-isoindolyl group, a 4-isoindolyl group, a5-isoindolyl group, a 1-indolyl group, a 2-indolyl group, a 3-indolylgroup, a 4-indolyl group, a 5-indolyl group, a 6-indolyl group, a7-indolyl group, 1-indazolyl group, a 2-indazolyl group, a 3-indazolylgroup, a 4-indazolyl group, a 5-indazolyl group, a 6-indazolyl group, a7-indazolyl group, a 1-purinyl group, a 2-purinyl group, 3-purinylgroup, a 6-purinyl group, a 7-purinyl group, 8-purinyl group, a2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolylgroup, a 6-quinolyl group, a 7-quinolyl group, a 8-quinolyl group, a1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group, a8-isoquinolyl group, a 1-phthalazinyl group, a 5-phthalazinyl group, a6-phthalazinyl group, a 1-2,7-naphthyridinyl group, a3-2,7-naphthyridinyl group, a 4-2,7-naphthyridinyl group, a1-2,6-naphthyridinyl group, a 3-2,6-naphthyridinyl group, a4-2,6-naphthyridinyl group, a 2-1,8-naphthyridinyl group, a3-1,8-naphthyridinyl group, a 4-1,8-naphthyridinyl group, a2-1,7-naphthyridinyl group, a 3-1,7-naphthyridinyl group, a4-1,7-naphthyridinyl group, a 5-1,7-naphthyridinyl group, a6-1,7-naphthyridinyl group, a 8-1,7-naphthyridinyl group,2-1,6-naphthyridinyl group, a 3-1,6-naphthyridinyl group, a4-1,6-naphthyridinyl group, a 5-1,6-naphthyridinyl group, a7-1,6-naphthyridinyl group, a 8-1,6-naphthyridinyl group, a2-1,5-naphthyridinyl group, a 3-1,5-naphthyridinyl group,4-1,5-naphthyridinyl group, a 6-1,5-naphthyridinyl group, a7-1,5-naphthyridinyl group, a 8-1,5-naphthyridinyl group, a2-quinoxalinyl group, a 5-quinoxalinyl group, a 6-quinoxalinyl group, a2-quinazolinyl group, a 4-quinazolinyl group, a 5-quinazolinyl group, a6-quinazolinyl group, a 7-quinazolinyl group, a 8-quinazolinyl group, a3-cinnolinyl group, a 4-cinnolinyl group, a 5-cinnolinyl group, a6-cinnolinyl group, a 7-cinnolinyl group, a 8-cinnolinyl group, a2-pterdinyl group, a 4-pterdinyl group, a 6-pterdinyl group, a7-pterdinyl group or the like.

A C₂₋₁₄ aryloxy group may be a C₆₋₁₄ aryloxy group so containing nohetero atoms as ring constituting atoms or a C₂₋₉ aromatic heterocyclicoxy group, and a C₂₋₉ aromatic heterocyclic oxy group may be a 5 to7-membered C₂₋₆ heteromonocyclic oxy group or 8 to 10-membered C₅₋₉fused heterobicyclic oxy group containing from 1 to 3 oxygen atoms,nitrogen atoms or sulfur atoms singly or in combination.

As a C₆₋₁₄ aryloxy group containing no hetero atoms, a phenyloxy group,a 1-indenyloxy group, a 2-indenyloxy group, a 3-indenyloxy group, a4-indenyloxy group, a 5-indenyloxy group, a 6-indenyloxy group, a7-indenyloxy group, an α-naphthyloxy group, a β-naphthyloxy group, a1-tetrahydronaphthyloxy group, a 2-tetrahydronaphthyloxy group, a5-tetrahydronaphthyloxy group, a 6-tetrahydronaphthyloxy group, ano-biphenylyloxy group, a m-biphenylyloxy group, a p-biphenylyloxy group,a 1-anthryloxy group, a 2-anthryloxy group, a 9-anthryloxy group, a1-phenanthryloxy group, a 2-phenanthryloxy group, a 3-phenanthryloxygroup, a 4-phenanthryloxy group, a 9-phenanthryloxy group or the likemay be mentioned.

A 5 to 7-membered C₂₋₆ heteromonocyclic oxy group may be a 2-thienyloxygroup, a 3-thienyloxy group, a 2-furyloxy group, a 3-furyloxy group, a2-pyranyloxy group, a 3-pyranyloxy group, a 4-pyranyloxy group, a1-pyrrolyloxy group, a 2-pyrrolyloxy group, a 3-pyrrolyloxy group, a1-imidazolyloxy group, a 2-imidazolyloxy group, a 4-imidazolyloxy group,a 1-pyrazolyloxy group, a 3-pyrazolyloxy group, a 4-pyrazolyloxy group,a 2-thiazolyloxy group, a 4-thiazolyloxy group, a 5-thiazolyloxy group,a 3-isothiazolyloxy group, a 4-isothiazolyloxy group, a5-isothiazolyloxy group, a 2-oxazolyloxy group, a 4-oxazolyloxy group, a5-oxazolyloxy group, a 3-isoxazolyloxy group, a 4-isoxazolyloxy group, a5-isoxazolyloxy group, a 2-pyridyloxy group, a 3-pyridyloxy group, a4-pyridyloxy group, a 2-pyrazinyloxy group, a 2-pyrimidinyloxy group, a4-pyrimidinyloxy group, a 5-pyrimidinyloxy group, a 3-pyridazinyloxygroup, a 4-pyridazinyloxy group, a 2-1,3,4-oxadiazolyloxy group, a2-1,3,4-thiadiazolyloxy group, a 3-1,2,4-oxadiazolyloxy group, a5-1,2,4-oxadiazolyloxy group, a 3-1,2,4-thiadiazolyloxy group, a5-1,2,4-thiadiazolyloxy group, a 3-1,2,5-oxadiazolyloxy group, a3-1,2,5-thiadiazolyloxy group or the like.

A 8 to 10-membered C₅₋₉ fused heterocyclic oxy group may be a2-benzofuranyloxy group, a 3-benzofuranyloxy group, a 4-benzofuranyloxygroup, a 5-benzofuranyloxy group, a 6-benzofuranyloxy group, a7-benzofuranyloxy group, a 1-isobenzofuranyloxy group, a4-isobenzofuranyloxy group, a 5-isobenzofuranyloxy group, a2-benzothienyloxy group, a 3-benzothienyloxy group, a 4-benzothienyloxygroup, a 5-benzothienyloxy group, a 6-benzothienyloxy group, a7-benzothienyloxy group, a 1-isobenzothienyloxy group, a4-isobenzothienyloxy group, a 5-isobenzothienyloxy group, a2-chromenyloxy group, a 3-chromenyloxy group, a 4-chromenyloxy group, a5-chromenyloxy group, a 6-chromenyloxy group, a 7-chromenyloxy group, a8-chromenyloxy group, a 1-indolizinyloxy group, a 2-indolizinyloxygroup, a 3-indolizinyloxy group, a 5-indolizinyloxy group, a6-indolizinyloxy group, a 7-indolizinyloxy group, a 8-indolizinyloxygroup, a 1-isoindolyloxy group, a 2-isoindolyloxy group, a4-isoindolyloxy group, a 5-isoindolyloxy group, a 1-indolyloxy group, a2-indolyloxy group, a 3-indolyloxy group, a 4-indolyloxy group, a5-indolyloxy group, a 6-indolyloxy group, a 7-indolyloxy group,1-indazolyloxy group, a 2-indazolyloxy group, a 3-indazolyloxy group, a4-indazolyloxy group, a 5-indazolyloxy group, a 6-indazolyloxy group, a7-indazolyloxy group, a 1-purinyloxy group, a 2-purinyloxy group, a3-purinyloxy group, a 6-purinyloxy group, a 7-purinyloxy group, a8-purinyloxy group, a 2-quinolyloxy group, a 3-quinolyloxy group, a4-quinolyloxy group, a 5-quinolyloxy group, a 6-quinolyloxy group, a7-quinolyloxy group, a 8-quinolyloxy group, a 1-isoquinolyloxy group, a3-isoquinolyloxy group, a 4-isoquinolyloxy group, a 5-isoquinolyloxygroup, a 6-isoquinolyloxy group, a 7-isoquinolyloxy group, a8-isoquinolyloxy group, a 1-phthalazinyloxy group, a 5-phthalazinyloxygroup, a 6-phthalazinyloxy group, a 1-2,7-naphthyridinyloxy group, a3-2,7-naphthyridinyloxy group, a 4-2,7-naphthyridinyloxy group, a1-2,6-naphthyridinyloxy group, a 3-2,6-naphthyridinyloxy group, a4-2,6-naphthyridinyloxy group, a 2-1,8-naphthyridinyloxy group, a3-1,8-naphthyridinyloxy group, a 4-1,8-naphthyridinyloxy group, a2-1,7-naphthyridinyloxy group, a 3-1,7-naphthyridinyloxy group, a4-1,7-naphthyridinyloxy group, a 5-1,7-naphthyridinyloxy group, a6-1,7-naphthyridinyloxy group, a 8-1,7-naphthyridinyloxy group,2-1,6-naphthyridinyloxy group, a 3-1,6-naphthyridinyloxy group, a4-1,6-naphthyridinyloxy group, a 5-1,6-naphthyridinyloxy group, a7-1,6-naphthyridinyloxy group, a 8-1,6-naphthyridinyloxy group, a2-1,5-naphthyridinyloxy group, a 3-1,5-naphthyridinyloxy group, a4-1,5-naphthyridinyloxy group, a 6-1,5-naphthyridinyloxy group, a7-1,5-naphthyridinyloxy group, a 8-1,5-naphthyridinyloxy group, a2-quinoxalinyloxy group, a 5-quinoxalinyloxy group, a 6-quinoxalinyloxygroup, a 2-quinazolinyloxy group, a 4-quinazolinyloxy group, a5-quinazolinyloxy group, a 6-quinazolinyloxy group, a 7-quinazolinyloxygroup, a 8-quinazolinyloxy group, a 3-cinnolinyloxy group, a4-cinnolinyloxy group, a 5-cinnolinyloxy group, a 6-cinnolinyloxy group,a 7-cinnolinyloxy group, a 8-cinnolinyloxy group, a 2-pterdinyloxygroup, a 4-pterdinyloxy group, a 6-pterdinyloxy group, a 7-pterdinyloxygroup or the like.

A C₁₋₆ alkylcarbonyl group may linear, branched or a C₃₋₆cycloalkylcarbonyl group, and be methylcarbonyl, ethylcarbonyl,n-propylcarbonyl, i-propylcarbonyl, c-propylcarbonyl, n-butylcarbonyl,i-butylcarbonyl, s-butylcarbonyl, t-butylcarbonyl, c-butylcarbonyl,1-methyl-c-propylcarbonyl, 2-methyl-c-propylcarbonyl, n-pentylcarbonyl,1-methyl-n-butylcarbonyl, 2-methyl-n-butylcarbonyl,3-methyl-n-butylcarbonyl, 1,1-dimethyl-n-propylcarbonyl,1,2-dimethyl-n-propylcarbonyl, 2,2-dimethyl-n-propylcarbonyl,1-ethyl-n-propylcarbonyl, c-pentylcarbonyl, 1-methyl-c-butylcarbonyl,2-methyl-c-butylcarbonyl, 3-methyl-c-butylcarbonyl,1,2-dimethyl-c-propylcarbonyl, 2,3-dimethyl-c-propylcarbonyl,1-ethyl-c-propylcarbonyl, 2-ethyl-c-propylcarbonyl, n-hexylcarbonyl,1-methyl-n-pentylcarbonyl, 2-methyl-n-pentylcarbonyl,3-methyl-n-pentylcarbonyl, 4-methyl-n-pentylcarbonyl,1,1-dimethyl-n-butylcarbonyl, 1,2-dimethyl-n-butylcarbonyl,1,3-dimethyl-n-butylcarbonyl, 2,2-dimethyl-n-butylcarbonyl,2,3-dimethyl-n-butylcarbonyl, 3,3-dimethyl-n-butylcarbonyl,1-ethyl-n-butylcarbonyl, 2-ethyl-n-butylcarbonyl,1,1,2-trimethyl-n-propylcarbonyl, 1,2,2-trimethyl-n-propylcarbonyl,1-ethyl-1-methyl-n-propylcarbonyl, 1-ethyl-2-methyl-n-propylcarbonyl,c-hexylcarbonyl, 1-methyl-c-pentylcarbonyl, 2-methyl-c-pentylcarbonyl,3-methyl-c-pentylcarbonyl, 1-ethyl-c-butylcarbonyl,2-ethyl-c-butylcarbonyl, 3-ethyl-c-butylcarbonyl,1,2-dimethyl-c-butylcarbonyl, 1,3-dimethyl-c-butylcarbonyl,2,2-dimethyl-c-butylcarbonyl, 2,3-dimethyl-c-butylcarbonyl,2,4-dimethyl-c-butylcarbonyl, 3,3-dimethyl-c-butylcarbonyl,1-n-propyl-c-propylcarbonyl, 2-n-propyl-c-propylcarbonyl,1-i-propyl-c-propylcarbonyl, 2-i-propyl-c-propylcarbonyl,1,2,2-trimethyl-c-propylcarbonyl, 1,2,3-trimethyl-c-propylcarbonyl,2,2,3-trimethyl-c-propylcarbonyl, 1-ethyl-2-methyl-c-propylcarbonyl,2-ethyl-1-methyl-c-propylcarbonyl, 2-ethyl-2-methyl-c-propylcarbonyl,2-ethyl-3-methyl-c-propylcarbonyl or the like may be mentioned.

A C₁₋₁₀ alkylcarbonyl may be linear, branched or a C₃₋₁₀cycloalkylcarbonyl group, and in addition to those mentioned above,1-methyl-1-ethyl-n-pentylcarbonyl, 1-heptylcarbonyl, 2-heptylcarbonyl,1-ethyl-1,2-dimethyl-n-propylcarbonyl,1-ethyl-2,2-dimethyl-n-propylcarbonyl, 1-octylcarbonyl, 3-octylcarbonyl,4-methyl-3-n-heptylcarbonyl, 6-methyl-2-n-heptylcarbonyl,2-propyl-1-n-heptylcarbonyl, 2,4,4-trimethyl-1-n-pentylcarbonyl,1-nonylcarbonyl, 2-nonylcarbonyl, 2,6-dimethyl-4-n-heptylcarbonyl,3-ethyl-2,2-dimethyl-3-n-pentylcarbonyl,3,5,5-trimethyl-1-n-hexylcarbonyl, 1-decylcarbonyl, 2-decylcarbonyl,4-decylcarbonyl, 3,7-dimethyl-1-n-octylcarbonyl,3,7-dimethyl-3-n-octylcarbonyl or the like may be mentioned.

A C₁₋₁₀ alkoxy group may be linear, branched or a C₃₋₁₀ cycloalkoxygroup, and methoxy, ethoxy, n-propoxy, i-propoxy, c-propoxy, n-butoxy,i-butoxy, s-butoxy, t-butoxy, c-butoxy, 1-methyl-c-propoxy,2-methyl-c-propoxy, n-pentyloxy, 1-methyl-n-butoxy, 2-methyl-n-butoxy,3-methyl-n-butoxy, 1,1-dimethyl-n-propoxy, 1,2-dimethyl-n-propoxy,2,2-dimethyl-n-propoxy, 1-ethyl-n-propoxy, c-pentyloxy,1-methyl-c-butoxy, 2-methyl-c-butoxy, 3-methyl-c-butoxy,1,2-dimethyl-c-propoxy, 2,3-dimethyl-c-propoxy, 1-ethyl-c-propoxy,2-ethyl-c-propoxy, n-hexyloxy, 1-methyl-n-pentyloxy,2-methyl-n-pentyloxy, 3-methyl-n-pentyloxy, 4-methyl-n-pentyloxy,1,1-dimethyl-n-butoxy, 1,2-dimethyl-n-butoxy, 1,3-dimethyl-n-butoxy,2,2-dimethyl-n-butoxy, 2,3-dimethyl-n-butoxy, 3,3-dimethyl-n-butoxy,1-ethyl-n-butoxy, 2-ethyl-n-butoxy, 1,1,2-trimethyl-n-propoxy,1,2,2-trimethyl-n-propoxy, 1-ethyl-1-methyl-n-propoxy,1-ethyl-2-methyl-n-propoxy, c-hexyloxy, 1-methyl-c-pentyloxy,2-methyl-c-pentyloxy, 3-methyl-c-pentyloxy, 1-ethyl-c-butoxy,2-ethyl-c-butoxy, 3-ethyl-c-butoxy, 1,2-dimethyl-c-butoxy,1,3-dimethyl-c-butoxy, 2,2-dimethyl-c-butoxy, 2,3-dimethyl-c-butoxy,2,4-dimethyl-c-butoxy, 3,3-dimethyl-c-butoxy, 1-n-propyl-c-propoxy,2-n-propyl-c-propoxy, 1-i-propyl-c-propoxy, 2-1-propyl-c-propoxy,1,2,2-trimethyl-c-propoxy, 1,2,3-trimethyl-c-propoxy,2,2,3-trimethyl-c-propoxy, 1-ethyl-2-methyl-c-propoxy,2-ethyl-1-methyl-c-propoxy, 2-ethyl-2-methyl-c-propoxy,2-ethyl-3-methyl-c-propoxy, 1-methyl-1-ethyl-n-pentyloxy, 1-heptyloxy,2-heptyloxy, 1-ethyl-1,2-dimethyl-n-propyloxy,1-ethyl-2,2-dimethyl-n-propyloxy, 1-octyloxy, 3-octyloxy,4-methyl-3-n-heptyloxy, 6-methyl-2-n-heptyloxy, 2-propyl-1-n-heptyloxy,2,4,4-trimethyl-1-n-pentyloxy, 1-nonyloxy, 2-nonyloxy,2,6-dimethyl-4-n-heptyloxy, 3-ethyl-2,2-dimethyl-3-n-pentyloxy,3,5,5-trimethyl-1-n-hexyloxy, 1-decyloxy, 2-decyloxy, 4-decyloxy,3,7-dimethyl-1-n-octyloxy, 3,7-dimethyl-3-n-octyloxy or the like may bementioned.

A C₁₋₆ alkoxycarbonyl group may be linear, branched or a C₃₋₆cycloalkoxycarbonyl group, and methoxycarbonyl, ethoxycarbonyl,n-propoxycarbonyl, i-propoxycarbonyl, c-propylcarbonyl,n-butoxycarbonyl, i-butoxycarbonyl, s-butoxycarbonyl, t-butoxycarbonyl,c-butoxycarbonyl, 1-methyl-c-propoxycarbonyl,2-methyl-c-propoxycarbonyl, n-pentyloxycarbonyl,1-methyl-n-butoxycarbonyl, 2-methyl-n-butoxycarbonyl,3-methyl-n-butoxycarbonyl, 1,1-dimethyl-n-propoxycarbonyl,1,2-dimethyl-n-propoxycarbonyl, 2,2-dimethyl-n-propoxycarbonyl,1-ethyl-n-propoxycarbonyl, c-pentyloxycarbonyl,1-methyl-c-butoxycarbonyl, 2-methyl-c-butoxycarbonyl,3-methyl-c-butoxycarbonyl, 1,2-dimethyl-c-propoxycarbonyl,2,3-dimethyl-c-propoxycarbonyl, 1-ethyl-c-propoxycarbonyl,2-ethyl-c-propoxycarbonyl, n-hexyloxycarbonyl,1-methyl-n-pentyloxycarbonyl, 2-methyl-n-pentyloxycarbonyl,3-methyl-n-pentyloxycarbonyl, 4-methyl-n-pentyloxycarbonyl,1,1-dimethyl-n-butoxycarbonyl, 1,2-dimethyl-n-butoxycarbonyl,1,3-dimethyl-n-butoxycarbonyl, 2,2-dimethyl-n-butoxycarbonyl,2,3-dimethyl-n-butoxycarbonyl, 3,3-dimethyl-n-butoxycarbonyl,1-ethyl-n-butoxycarbonyl, 2-ethyl-n-butoxycarbonyl,1,1,2-trimethyl-n-propoxycarbonyl, 1,2,2-trimethyl-n-propoxycarbonyl,1-ethyl-1-methyl-n-propoxycarbonyl, 1-ethyl-2-methyl-n-propoxycarbonyl,c-hexyloxycarbonyl, 1-methyl-c-pentyloxycarbonyl,2-methyl-c-pentyloxycarbonyl, 3-methyl-c-pentyloxycarbonyl,1-ethyl-c-butoxycarbonyl, 2-ethyl-c-butoxycarbonyl,3-ethyl-c-butoxycarbonyl, 1,2-dimethyl-c-butoxycarbonyl,1,3-dimethyl-c-butoxycarbonyl, 2,2-dimethyl-c-butoxycarbonyl,2,3-dimethyl-c-butoxycarbonyl, 2,4-dimethyl-c-butoxycarbonyl,3,3-dimethyl-c-butoxycarbonyl, 1-n-propyl-c-propoxycarbonyl,2-n-propyl-c-propoxycarbonyl, 1-i-propyl-c-propoxycarbonyl,2-i-propyl-c-propoxycarbonyl, 1,2,2-trimethyl-c-propoxycarbonyl,1,2,3-trimethyl-c-propoxycarbonyl, 2,2,3-trimethyl-c-propoxycarbonyl,1-ethyl-2-methyl-c-propoxycarbonyl, 2-ethyl-1-methyl-c-propoxycarbonyl,2-ethyl-2-methyl-c-propoxycarbonyl, 2-ethyl-3-methyl-c-propoxycarbonylor the like may be mentioned.

A C₁₋₁₀ alkoxycarbonyl group may be linear, branched or a C₃₋₁₀cycloalkoxycarbonyl group, and in addition to those mentioned above,1-methyl-1-ethyl-n-pentyloxycarbonyl, 1-heptyloxycarbonyl, 2-sheptyloxycarbonyl, 1-ethyl-1,2-dimethyl-n-propyloxycarbonyl,1-ethyl-2,2-dimethyl-n-propyloxycarbonyl, 1-octyloxycarbonyl,3-octyloxycarbonyl, 4-methyl-3-n-heptyloxycarbonyl,methyl-2-n-heptyloxycarbonyl, 2-propyl-1-n-heptyloxycarbonyl,2,4,4-trimethyl-1-n-pentyloxycarbonyl, 1-nonyloxycarbonyl,2-nonyloxycarbonyl, 2,6-dimethyl-4-n-heptyloxycarbonyl,3-ethyl-2,2-dimethyl-3-n-pentyloxycarbonyl,3,5,5-trimethyl-1-n-hexyloxycarbonyl, 1-decyloxycarbonyl,2-decyloxycarbonyl, 4-decyloxycarbonyl,3,7-dimethyl-1-n-octyloxycarbonyl, 3,7-dimethyl-3-n-octyloxycarbonyl orthe like may be mentioned.

A C₁₋₁₀ alkylcarbonyloxy group may be linear, branched or a C₃₋₁₀cycloalkylcarbonyloxy group, and methylcarbonyloxy, ethylcarbonyloxy,n-propylcarbonyloxy, i-propylcarbonyloxy, c-propylcarbonyloxy,n-butylcarbonyloxy, i-butylcarbonyloxy, s-butylcarbonyloxy,t-butylcarbonyloxy, c-butylcarbonyloxy, 1-methyl-c-propylcarbonyloxy,2-methyl-c-propylcarbonyloxy, n-pentylcarbonyloxy,1-methyl-n-butylcarbonyloxy, 2-methyl-n-butylcarbonyloxy,3-methyl-n-butylcarbonyloxy, 1,1-dimethyl-n-propylcarbonyloxy,1,2-dimethyl-n-propylcarbonyloxy, 2,2-dimethyl-n-propylcarbonyloxy,1-ethyl-n-propylcarbonyloxy, c-pentylcarbonyloxy,1-methyl-c-butylcarbonyloxy, 2-methyl-c-butylcarbonyloxy,3-methyl-c-butylcarbonyloxy, 1,2-dimethyl-c-propylcarbonyloxy,2,3-dimethyl-c-propylcarbonyloxy, 1-ethyl-c-propylcarbonyloxy,2-ethyl-c-propylcarbonyloxy, n-hexylcarbonyloxy,1-methyl-n-pentylcarbonyloxy, 2-methyl-n-pentylcarbonyloxy,3-methyl-n-pentylcarbonyloxy, 4-methyl-n-pentylcarbonyloxy,1,1-dimethyl-n-butylcarbonyloxy, 1,2-dimethyl-n-butylcarbonyloxy,1,3-dimethyl-n-butylcarbonyloxy, 2,2-dimethyl-n-butylcarbonyloxy,2,3-dimethyl-n-butylcarbonyloxy, 3,3-dimethyl-n-butylcarbonyloxy,1-ethyl-n-butylcarbonyloxy, 2-ethyl-n-butylcarbonyloxy,1,1,2-trimethyl-n-propylcarbonyloxy,1,2,2-trimethyl-n-propylcarbonyloxy,1-ethyl-1-methyl-n-propylcarbonyloxy,1-ethyl-2-methyl-n-propylcarbonyloxy, c-hexylcarbonyloxy,1-methyl-c-pentylcarbonyloxy, 2-methyl-c-pentylcarbonyloxy,3-methyl-c-pentylcarbonyloxy, 1-ethyl-c-butylcarbonyloxy,2-ethyl-c-butylcarbonyloxy, 3-ethyl-c-butylcarbonyloxy,1,2-dimethyl-c-butylcarbonyloxy, 1,3-dimethyl-c-butylcarbonyloxy,2,2-dimethyl-c-butylcarbonyloxy, 2,3-dimethyl-c-butylcarbonyloxy,2,4-dimethyl-c-butylcarbonyloxy, 3,3-dimethyl-c-butylcarbonyloxy,1-n-propyl-c-propylcarbonyloxy, 2-n-propyl-c-propylcarbonyloxy,1-i-propyl-c-propylcarbonyloxy, 2-i-propyl-c-propylcarbonyloxy,1,2,2-trimethyl-c-propylcarbonyloxy,1,2,3-trimethyl-c-propylcarbonyloxy,2,2,3-trimethyl-c-propylcarbonyloxy,1-ethyl-2-methyl-c-propylcarbonyloxy,2-ethyl-1-methyl-c-propylcarbonyloxy,2-ethyl-2-methyl-c-propylcarbonyloxy,2-ethyl-3-methyl-c-propylcarbonyloxy,1-methyl-1-ethyl-n-pentylcarbonyloxy, 1-heptylcarbonyloxy,2-heptylcarbonyloxy, 1-ethyl-1,2-dimethyl-n-propylcarbonyloxy,1-ethyl-2,2-dimethyl-n-propylcarbonyloxy, 1-octylcarbonyloxy,3-octylcarbonyloxy, 4-methyl-3-n-heptylcarbonyloxy,6-methyl-2-n-heptylcarbonyloxy, 2-propyl-1-n-heptylcarbonyloxy,2,4,4-trimethyl-1-n-pentylcarbonyloxy, 1-nonylcarbonyloxy,2-nonylcarbonyloxy, 2,6-dimethyl-4-n-heptylcarbonyloxy,3-ethyl-2,2-dimethyl-3-n-pentylcarbonyloxy,3,5,5-trimethyl-1-n-hexylcarbonyloxy, 1-decylcarbonyloxy,2-decylcarbonyloxy, 4-decylcarbonyloxy,3,7-dimethyl-1-n-octylcarbonyloxy, 3,7-dimethyl-3-n-octylcarbonyloxy orthe like may be mentioned.

A C₁₋₁₀ alkylcarbonylamino group may be linear, branched or a C₃₋₁₀cycloalkylcarbonylamino group, and methylcarbonylamino,ethylcarbonylamino, n-propylcarbonylamino, i-propylcarbonylamino,c-propylcarbonylamino, n-butylcarbonylamino, i-butylcarbonylamino,s-butylcarbonylamino, t-butylcarbonylamino, c-butylcarbonylamino,1-methyl-c-propylcarbonylamino, 2-methyl-c-propylcarbonylamino,n-pentylcarbonylamino, 1-methyl-n-butylcarbonylamino,2-methyl-n-butylcarbonylamino, 3-methyl-n-butylcarbonylamino,1,1-dimethyl-n-propylcarbonylamino, 1,2-dimethyl-n-propylcarbonylamino,2,2-dimethyl-n-propylcarbonylamino, 1-ethyl-n-propylcarbonylamino,c-pentylcarbonylamino, 1-methyl-c-butylcarbonylamino,2-methyl-c-butylcarbonylamino, 3-methyl-c-butylcarbonylamino,1,2-dimethyl-c-propylcarbonylamino, 2,3-dimethyl-c-propylcarbonylamino,1-ethyl-c-propylcarbonylamino, 2-ethyl-c-propylcarbonylamino,n-hexylcarbonylamino, 1-methyl-n-pentylcarbonylamino,methyl-n-pentylcarbonylamino, 3-methyl-n-pentylcarbonylamino,4-methyl-n-pentylcarbonylamino, 1,1-dimethyl-n-butylcarbonylamino,1,2-dimethyl-n-butylcarbonylamino, 1,3-dimethyl-n-butylcarbonylamino,2,2-dimethyl-n-butylcarbonylamino, 2,3-dimethyl-n-butylcarbonylamino,3,3-dimethyl-n-butylcarbonylamino, 1-ethyl-n-butylcarbonylamino,2-ethyl-n-butylcarbonylamino, 1,1,2-trimethyl-n-propylcarbonylamino,1,2,2-trimethyl-n-propylcarbonylamino,1-ethyl-1-methyl-n-propylcarbonylamino,1-ethyl-2-methyl-n-propylcarbonylamino, c-hexylcarbonylamino,1-methyl-c-pentylcarbonylamino, 2-methyl-c-pentylcarbonylamino,3-methyl-c-pentylcarbonylamino, 1-ethyl-c-butylcarbonylamino,2-ethyl-c-butylcarbonylamino, 3-ethyl-c-butylcarbonylamino,1,2-dimethyl-c-butylcarbonylamino, 1,3-dimethyl-c-butylcarbonylamino,2,2-dimethyl-c-butylcarbonylamino, 2,3-dimethyl-c-butylcarbonylamino,2,4-dimethyl-c-butylcarbonylamino, 3,3-dimethyl-c-butylcarbonylamino,1-n-propyl-c-propylcarbonylamino, 2-n-propyl-c-propylcarbonylamino,1-i-propyl-c-propylcarbonylamino, 2-i-propyl-propylcarbonylamino,1,2,2-trimethyl-c-propyl-carbonylamino,1,2,3-trimethyl-c-propylcarbonylamino,2,2,3-trimethyl-c-propylcarbonylamino,1-ethyl-2-methyl-c-propylcarbonylamino,2-ethyl-1-methyl-c-propylcarbonylamino,2-ethyl-2-methyl-c-propylcarbonylamino,2-ethyl-3-methyl-c-propylcarbonylamino,1-methyl-1-ethyl-n-pentylcarbonylamino, 1-heptylcarbonylamino,2-heptylcarbonylamino, 1-ethyl-1,2-dimethyl-n-propylcarbonylamino,1-ethyl-2,2-dimethyl-n-propylcarbonylamino, 1-octylcarbonylamino,3-octylcarbonylamino, 4-methyl-3-n-heptylcarbonylamino,6-methyl-2-n-heptylcarbonylamino, 2-propyl-1-n-heptylcarbonylamino,2,4,4-trimethyl-1-n-pentylcarbonylamino, 1-nonylcarbonylamino,2-nonylcarbonylamino, 2,6-dimethyl-4-n-heptylcarbonylamino,3-ethyl-2,2-dimethyl-3-n-pentylcarbonylamino,3,5,5-trimethyl-1-n-hexylcarbonylamino, 1-decylcarbonylamino,2-decylcarbonylamino, 4-decylcarbonylamino,3,7-dimethyl-1-n-octylcarbonylamino, 3,7-dimethyl-3-n-octylcarbonylaminoor the like may be mentioned.

A C₁₋₁₀ monoalkylamino group may be linear, branched or a C₃₋₁₀cycloalkylamino group, and methylamino, ethylamino, n-propylamino,i-propylamino, c-propylamino, n-butylamino, i-butylamino, s-butylamino,t-butylamino, c-butylamino, 1-methyl-c-propylamino,2-methyl-c-propylamino, n-pentylamino, 1-methyl-n-butylamino,2-methyl-n-butylamino, 3-methyl-n-butylamino,1,1-dimethyl-n-propylamino, 1,2-dimethyl-n-propylamino,2,2-dimethyl-n-propylamino, 1-ethyl-n-propylamino, c-pentylamino,1-methyl-c-butylamino, 2-methyl-c-butylamino, 3-methyl-c-butylamino,1,2-dimethyl-c-propylamino, 2,3-dimethyl-propylamino,1-ethyl-c-propylamino, 2-ethyl-c-propylamino, n-hexylamino,1-methyl-n-pentylamino, 2-methyl-n-pentylamino, 3-methyl-n-pentylamino,4-methyl-n-pentylamino, 1,1-dimethyl-n-butylamino,1,2-dimethyl-n-butylamino, 1,3-dimethyl-n-butylamino,2,2-dimethyl-n-butylamino, 2,3-dimethyl-n-butylamino,3,3-dimethyl-n-butylamino, 1-ethyl-n-butylamino, 2-ethyl-n-butylamino,1,1,2-trimethyl-n-propylamino, 1,2,2-trimethyl-n-propylamino,1-ethyl-1-methyl-n-propylamino, 1-ethyl-2-methyl-n-propylamino,c-hexylamino, 1-methyl-c-pentylamino, 2-methyl-c-pentylamino,3-methyl-c-pentylamino, 1-ethyl-c-butylamino, 2-ethyl-c-butylamino,3-ethyl-c-butylamino, 1,2-dimethyl-c-butylamino,1,3-dimethyl-c-butylamino, 2,2-dimethyl-c-butylamino,2,3-dimethyl-c-butylamino, 2,4-dimethyl-c-butylamino,3,3-dimethyl-c-butylamino, 1-n-propyl-c-propylamino,2-n-propyl-c-propylamino, 1-i-propyl-c-propylamino,2-i-propyl-c-propylamino, 1,2,2-trimethyl-c-propylamino,1,2,3-trimethyl-c-propylamino, 2,2,3-trimethyl-c-propylamino,1-ethyl-2-methyl-c-propylamino, 2-ethyl-1-methyl-c-propylamino,2-ethyl-2-methyl-c-propylamino, 2-ethyl-3-methyl-c-propylamino,1-methyl-1-ethyl-n-pentylamino, 1-heptylamino, 2-heptylamino,1-ethyl-1,2-dimethyl-n-propylamino, 1-ethyl-2,2-dimethyl-n-propylamino,1-octylamino, 3-octylamino, 4-methyl-3-n-heptylamino,6-methyl-2-n-heptylamino, 2-propyl-1-n-heptylamino,2,4,4-trimethyl-1-n-pentylamino, 1-nonylamino, 2-nonylamino,2,6-dimethyl-4-n-heptylamino, 3-ethyl-2,2-dimethyl-3-n-pentylamino,3,5,5-trimethyl-1-n-hexylamino, 1-decylamino, 2-decylamino,4-decylamino, 3,7-dimethyl-1-n-octylamino, 3,7-dimethyl-3-n-octylaminoor the like may be mentioned.

A C₁₋₁₀ dialkylamino group may be symmetric or asymmetric. A symmetricC₁₋₁₀ dialkylamino group may be linear, branched or a C₃₋₁₀cycloalkylamino group, and dimethylamino, diethylamino,di-n-propylamino, di-i-propylamino, di-c-propylamino, di-n-butylamino,di-i-butylamino, di-s-butylamino, di-t-butylamino, d-c-butylamino,di-(1-methyl-c-propyl)amino, di-(2-methyl-c-propyl)amino,di-n-pentylamino, di-(1-methyl-n-butyl)amino,di-(2-methyl-n-butyl)amino, di-(3-methyl-n-butyl)amino,di-(1,1-dimethyl-n-propyl)amino, di-(1,2-dimethyl-n-propyl)amino,di-(2,2-dimethyl-n-propyl)amino, di-(1-ethyl-n-propyl)amino,di-c-pentylamino, di-(1-methyl-c-butyl)amino,di-(2-methyl-c-butyl)amino, di-(3-methyl-c-butyl)amino,di-(1,2-dimethyl-c-propyl)amino, di-(2,3-dimethyl-c-propyl)amino,di-(1-ethyl-c-propyl)amino, di-(2-ethyl-c-propyl)amino, di-n-hexylamino,di-(1-methyl-n-pentyl)amino, di-(2-methyl-n-pentyl)amino,di-(3-methyl-n-pentyl)amino, di-(4-methyl-n-pentyl)amino,di-(1,1-dimethyl-n-butyl)amino, di-(1,2-dimethyl-n-butyl)amino,di-(1,3-dimethyl-n-butyl)amino, di-(2,2-dimethyl-n-butyl)amino,di-(2,3-dimethyl-n-butyl)amino, di-(3,3-dimethyl-n-butyl)amino,di-(1-ethyl-n-butyl)amino, di-(2-ethyl-n-butyl)amino,di-(1,1,2-trimethyl-n-propyl)amino, di-(1,2,2-trimethyl-n-propyl)amino,di-(1-ethyl-1-methyl-n-propyl)amino,di-(1-ethyl-2-methyl-n-propyl)amino, di-c-hexylamino,di-(1-methyl-c-pentyl)amino, di-(2-methyl-c-pentyl)amino,di-(3-methyl-c-pentyl)amino, di-(1-ethyl-c-butyl)amino,di-(2-ethyl-c-butyl)amino, di-(3-ethyl-c-butyl)amino,di-(1,2-dimethyl-c-butyl)amino, di-(1,3-dimethyl-c-butyl)amino,di-(2,2-dimethyl-c-butyl)amino, di-(2,3-dimethyl-c-butyl)amino,di-(2,4-dimethyl-c-butyl)amino, di-(3,3-dimethyl-c-butyl)amino,di-(1-n-propyl-propyl)amino, di-(2-n-propyl-c-propyl)amino,di-(1-i-propyl-c-propyl)amino, di-(2-i-propyl-c-propyl)amino,di-(1,2,2-trimethyl-c-propyl)amino, propyl)amino,di-(2,2,3-trimethyl-c-propyl)amino, di-(1-ethyl-2-methyl-c-propyl)amino,di-(2-ethyl-1-methyl-c-propyl)amino,di-(2-ethyl-2-methyl-c-propyl)amino,di-(2-ethyl-3-methyl-c-propyl)amino,di-(1-methyl-1-ethyl-n-pentyl)amino, di-(1-heptyl)amino,di-(2-heptyl)amino, di-(1-ethyl-1,2-dimethyl-n-propyl)amino,di-(1-ethyl-2,2-dimethyl-n-propyl)amino, di-(1-octyl)amino,di-(3-octyl)amino, di-(4-methyl-3-n-heptyl)amino,di-(6-methyl-2-n-heptyl)amino, di-(2-propyl-1-n-heptyl)amino,di-(2,4,4-trimethyl-1-n-pentyl)amino, di-(1-nonyl)amino,di-(2-nonyl)amino, di-(2,6-dimethyl-4-n-heptyl)amino,di-(3-ethyl-2,2-dimethyl-3-n-pentyl)amino,di-(3,5,5-trimethyl-1-n-hexyl)amino, di-(1-decyl)amino,di-(2-decyl)amino, di-(4-decyl)amino, di-(3,7-dimethyl-1-n-octyl)amino,di-(3,7-dimethyl-3-n-octyl)amino or the like may be mentioned.

An asymmetric C₁₋₁₀ dialkylamino group may be linear, branched or aC₃₋₁₀ cycloalkylamino group, and (methyl, ethyl)amino, (methyl,n-propyl)amino, (methyl, i-propyl)amino, (methyl, c-propyl)amino,(methyl, n-butyl)amino, (methyl, i-butyl)amino, (methyl, s-butyl)amino,(methyl, t-butyl)amino, (methyl, n-pentyl)amino, (methyl,c-pentyl)amino, (methyl, n-hexyl)amino, (methyl, c-hexyl)amino, (ethyl,n-propyl)amino, (ethyl, i-propyl)amino, (ethyl, c-propyl)amino, (ethyl,n-butyl)amino, (ethyl, i-butyl)amino, (ethyl, s-butyl)amino, (ethyl,t-butyl)amino, (ethyl, n-pentyl)amino, (ethyl, c-pentyl)amino, (ethyl,n-hexyl)amino, (ethyl, hexyl)amino, (n-propyl, i-propyl)amino,(n-propyl, c-propyl)amino, (n-propyl, n-butyl)amino, (n-propyl,butyl)amino, (n-propyl, s-butyl)amino, (n-propyl, t-butyl)amino,(n-propyl, n-pentyl)amino, (n-propyl, c-pentyl)amino, (n-propyl,n-hexyl)amino, (n-propyl, c-hexyl)amino, (i-propyl, c-propyl)amino,(i-propyl, n-butyl)amino, (i-propyl, i-butyl)amino, (i-propyl,s-butyl)amino, (i-propyl, t-butyl)amino, (i-propyl, n-pentyl)amino,(i-propyl, c-pentyl)amino, (i-propyl, n-hexyl)amino, (i-propyl,c-hexyl)amino, (c-propyl, butyl)amino, (c-propyl, i-butyl)amino,(c-propyl, s-butyl)amino, (c-propyl, t-butyl)amino, (c-propyl,n-pentyl)amino, (c-propyl, c-pentyl)amino, (c-propyl, n-hexyl)amino,(c-propyl, c-hexyl)amino, (n-butyl, i-butyl)amino, (n-butyl,s-butyl)amino, (n-butyl, t-butyl)amino, (n-butyl, n-pentyl)amino,(n-butyl, c-pentyl)amino, (n-butyl, n-hexyl)amino, (n-butyl,c-hexyl)amino, (i-butyl, s-butyl)amino, (i-butyl, t-butyl)amino,(i-butyl, n-pentyl)amino, (i-butyl, c-pentyl)amino, (i-butyl,n-hexyl)amino, (i-butyl, c-hexyl)amino, (s-butyl, t-butyl)amino,(s-butyl, pentyl)amino, (s-butyl, c-pentyl)amino, (s-butyl,n-hexyl)amino, (s-butyl, c-hexyl)amino, (t-butyl, n-pentyl)amino,(t-butyl, c-pentyl)amino, (t-butyl, n-hexyl)amino, (t-butyl,c-hexyl)amino, (n-pentyl, c-pentyl)amino, (n-pentyl, n-hexyl)amino,(n-pentyl, c-hexyl)amino, (c-pentyl, n-hexyl)amino, (c-pentyl,c-hexyl)amino, (n-hexyl, c-hexyl)amino, (methyl, n-heptyl)amino,(methyl, n-octyl)amino, (methyl, n-nonanyl)amino, (methyl,n-decyl)amino, (methyl, n-heptyl)amino, (ethyl, n-octyl)amino, (ethyl,n-nonanyl)amino, (ethyl, n-decyl)amino or the like may be mentioned.

The protecting group in a protected hydroxyl group may be a C₁₋₄alkoxymethyl group (such as MOM: methoxymethyl, MEM:2-methoxyethoxymethyl, ethoxymethyl, n-propoxymethyl, i-propoxymethyl,n-butoxymethyl, iBM: isobutyloxymethyl, BUM: t-butoxymethyl, POM:pivaloyloxymethyl, SEM: trimethylsilylethoxymethyl and the like,preferably a C₁₋₂ alkoxymethyl or the like), an aryloxymethyl (such asBOM: benzyloxymethyl, PMBM: p-methoxybenzyloxymethyl, p-AOM:p-anisyloxymethyl and the like, preferably benzyloxymethyl or the like),a C₁₋₄ alkylaminomethyl group (such as dimethylaminomethyl), asubstituted acetamidomethyl group (such as Acm: acetamidomethyl, Tacm:trimethylacetamidemethyl and the like), a substituted thiomethyl group(such as MTM: methylthiomethyl, PTM: phenylthiomethyl, Btm:benzylthiomethyl and the like), a carboxyl group, a C₁₋₇ acyl group(such as formyl, acetyl, fluoroacetyl, difluoroacetyl, trifluoroacetyl,chloroacetyl, dichloroacetyl, trichloroacetyl, propionyl, Pv: pivaloyl,tigloyl and the like), an arylcarbonyl group (such as benzoyl,benzoylformyl, benzoylpropionyl, phenylpropionyl and the like), a C₁₋₄alkoxycarbonyl group (such as methoxycarbonyl, ethoxycarbonyl,n-propoxycarbonyl, propoxycarbonyl, n-butoxycarbonyl, i-butoxycarbonyl,BOC: t-butoxycarbonyl, AOC: t-amyloxycarbonyl, VOC: vinyloxycarbonyl,AOC: allyloxycarbonyl, Teoc: 2-(trimethylsilyl)ethoxycarbonyl, Troc:2,2,2-trichloroethoxycarbonyl and the like, preferably BOC and thelike), an aryloxycarbonyl group (such as Z: benzyloxycarbonyl,p-nitrobenzyloxycarbonyl, MOZ: p-methoxybenzyloxycarbonyl and the like),a C₁₋₄ alkylaminocarbonyl group (such as methylcarbamoyl, Ec:ethylcarbamoyl, n-propylcarbamoyl, and the like), an arylaminocarbonylgroup (such as phenylcarbamoyl and the like), a trialkylsilyl group(such as TMS: trimethylsilyl, TES: triethylsilyl, TIPS:triisopropylsilyl, DEIPS: diethylisopropylsilyl, DMIPS:dimethylisopropylsilyl, DTBMS: di-t-butylmethylsilyl, IPDMS:isopropyldimethylsilyl, TBDMS: t-butyldimethylsilyl, TDS:thexyldimethylsilyl and the like, preferably t-butyldimethylsilyl andthe like), a trialkylarylsilyl group (such as DPMS: diphenylmethylsilyl,TBDPS: t-butyldiphenylsilyl, TBMPS: t-butyldimethoxyphenylsilyl, TPS:triphenylsilyl and the like), an alkylsulfonyl group, (such as Ms:methanesulfonyl, ethanesulfonyl and the like) or an arylsulfonyl group(such as benzenesulfonyl, Ts: p-toluenesulfonyl,p-chlorobenzenesulfonyl, MBS: p-methoxybenzenesulfonyl,m-nitrobenzenesulfonyl, iMds: 2,6-dimethoxy-4-methylbenzenesulfonyl,Mds: 2,6-dimethyl-4-methoxybenzenesulfonyl, Mtb:2,4,6-trimethoxybenzenesulfonyl, Mte:2,3,5,6-tetramethyl-4-methoxybenzenesulfonyl, Mtr:2,3,6-trimethyl-4-methoxybenzenesulfonyl, Mts:2,4,6-trimethylbenzenesulfonyl, Pme: pentamethylbenzenesulfonyl and thelike).

Specific preferred examples of the substituent R¹ are a phenyl group,thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups(a 2-furyl group and a 3-furyl group), pyridazinyl groups (a3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolylgroups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group)optionally substituted with one or more of the following substituents.

Substituents: a C₁₋₁₀ alkyl group, a halogen atom, a C₁₋₁₀ alkyl groupsubstituted with one or more halogen atoms, a nitro group, an aminogroup, an amino group substituted with one or two C₁₋₁₀ alkyl groups, anamino group substituted with a C₁₋₁₀ alkylcarbonyl group, a thiol groupsubstituted with a C₁₋₁₀ alkyl group, a thiol group substituted with aC₁₋₁₀ alkylcarbonyl group, hydroxyl group, a C₁₋₆ alkoxy group, a C₁₋₁₀alkoxy group substituted with one or more halogen atoms, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group and a C₁₋₁₀alkylcarbonyl group.

Particularly preferred examples of the substituent R¹ are a phenylgroup, thienyl groups (a 2-thienyl group and a 3-thienyl group), furylgroups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolylgroups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a6-isoquinolyl: group, a 7-isoquinolyl group and a 8-isoquinolyl group)optionally substituted with one or more of the following substituents.

Substituents: a methyl group, a t-butyl group, a trifluoromethyl group,a trifluoromethoxy group, a bromine atom, a chlorine atom, a fluorineatom, a methoxy group, a methylamino group, a dimethylamino group, at-butyloxy group and a t-butylamino group.

Still further preferred specific examples of the substituent are a3-methyl-phenyl group, a 4-methyl-phenyl group, a 3,4-dimethyl-phenylgroup, a 3-t-butyl-phenyl group, a 4-t-butyl-phenyl group, a3-trifluoromethyl-phenyl group, a 4-trifluoromethyl-phenyl group, a4-trifluoromethoxy-phenyl group, a 4-bromo-phenyl group, a3,4-ditrifluoromethyl-phenyl group, a 3-chloro-phenyl group, a4-chloro-phenyl group, a 3-fluoro-phenyl group, a 4-fluoro-phenyl group,a 3,4-dichloro-phenyl group, 3,4-difluoro-phenyl group, a4-methoxy-phenyl group, a 4-methylamino-phenyl group, a4-methyl-2-thienyl group, a 5-methyl-2-thienyl group, a4,5-dimethyl-2-thienyl group, a 4-t-butyl-2-thienyl group, a5-t-butyl-2-thienyl group, a 4-trifluoromethyl-2-thienyl group, a5-trifluoromethyl-2-thienyl group, a 4,5-ditrifluoromethyl-2-thienylgroup, a 4-chloro-2-thienyl group, a 5-chloro-2-thienyl group, a4-fluoro-2-thienyl group, a 5-fluoro-2-thienyl group, a4,5-dichloro-2-thienyl group, 4,5-ditrifluoromethyl-2-thienyl group, a5-methoxy-2-thienyl group, a 5-methylamino-2-thienyl group, a4-methyl-2-furyl group, a 5-methyl-2-furyl group, a 4,5-dimethyl-2-furylgroup, a 4-t-butyl-2-furyl group, a 5-t-butyl-2-furyl group, a4-trifluoromethyl-2-furyl group, a 5-trifluoromethyl-2-furyl group, a4,5-ditrifluoromethyl-2-furyl group, a 4-chloro-2-furyl group, a5-chloro-2-furyl group, a 4-fluoro-2-furyl group, a 5-fluoro-2-furylgroup, a 4,5-dichloro-2-furyl group, a 5-methoxy-2-furyl group, a5-methylamino-2-furyl group, a 6-chloro-3-pyridazinyl group, a6-methyl-3-pyridazinyl group, a 6-methoxy-3-pyridazinyl group, a6-chloro-3-pyridazinyl group, a 6-methylpyridazinyl group, a6-methoxy-3-pyridazinyl group, a 6-t-butoxy-3-pyridazinyl group, a5,6-dimethyl-3-pyridazinyl group, a 5,6-dichloro-3-pyridazinyl group, a6-t-butyl-3-pyridazinyl group, a 5-chloro-2-pyridyl group, a 5-strifluoromethyl-2-pyridyl group, a 5-methyl-2-pyridyl group, a4,5-dimethyl-2-pyridyl group, a 5,6-dimethyl-2-pyridyl group, a5-t-butyl-2-pyridyl group, a 4,5-dichloro-2-pyridyl group, a5,6-dichloro-2-pyridyl group and the like.

Specific preferable examples of L¹ are a bond, CH₂, a oxygen atom, asulfur atom, NH, N-Me, N—CHO, CHMe, CMe₂, N—CH₂Ph and the like, andparticularly preferable examples are a bond, CH₂, an oxygen atom, asulfur atom, NH, NMe and the like.

Specific preferable examples of the substituent R² are a hydrogen atom,a methyl group, an ethyl group, a n-propyl group, an i-propyl group, at-butyl group, and a phenyl group (the methyl group, the ethyl group,the n-propyl group, the i-propyl group, the t-butyl group and the phenylgroup may be optionally substituted with an amino group, amonomethylamino group, a dimethylamino group, a monoethylamino group, adiethylamino group, a methoxy group, an ethoxy group, a methoxycarbonylgroup, an ethoxycarbonyl group, a methylcarbonyloxy group, anethylcarbonyloxy group, a methylcarbonylamino group or anethylcarbonylamino group and the like), and particularly preferableexamples are a hydrogen atom, a methyl group, an ethyl group, a n-propylgroup, an i-propyl group, a t-butyl group, a phenyl group and the like.

Specific preferable examples of L² are a bond, CH₂, oxygen atom, asulfur atom, NH, N-Me, N—CHO, CHMe, CMe₂, N—CH₂Ph and the like, andparticularly preferable examples are a bond, CH₂, an oxygen atom, asulfur atom, NH, NMe and the like.

Specific preferable examples of L³ are a bond, CH₂, an oxygen atom, asulfur atom, NH, NH—OH, N-Me, N—CHO, CHMe, CMe₂, N—CH₂PH and the like,and particularly preferred examples are a bond, CH₂, an oxygen atom, asulfur atom, NH, NMe and the like.

Specific preferable examples of the substituent R³ are a phenyl group,thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups(a 2-furyl group and a 3-furyl group), pyridazinyl groups (a3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolylgroups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group)optionally substituted with one or more of the following substituents.

Substituents: a hydroxyl group, an amino group, a carboxyl group, aphosphonic acid group, a sulfonic acid group, a carbamido group, ahydroxycarbamido group, a cyanocarbamido group, a sulfamido group, ahydroxysulfamido group, a cyanosulfamido group, a tetrazole group,—CH₂CO₂H, —OCH₂CO₂H, —NHCH₂CO₂H, —CH₂CH₂CO₂H, an alkoxycarbonyl groupand the following heterocyclic groups substituted with a hydroxyl group.

Heterocyclic groups: a 1,3,4-oxadiazole group, a 1,3,4-thiadiazolegroup, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a 1,2-oxazole groupand a 1,2-thiazole group.

Still further, specific preferable examples of the substituent R³ are aphenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group),furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups(a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolylgroups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a5-quinolyl group, 6-quinolyl group, a 7-quinolyl group and a 8-quinolylgroup) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolylgroup, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolylgroup, a 7-isoquinolyl group and a 8-isoquinolyl group) optionallysubstituted with one or more substituents optionally selected fromsubstituent set A and with one or more substituents optionally selectedfrom substituent set B.

Substituent set A: a hydroxyl group, an amino group, a carboxyl group, aphosphonic acid group, a sulfonic acid, a carbamido group, ahydroxycarbamido group, a cyanocarbamido group, a sulfamido group,hydroxysulfamido group, a cyanosulfamido group, a tetrazole group,—CH₂CO₂H, —OCH₂CO₂H, —NHCH₂CO₂H, —CH₂CH₂CO₂H and an alkoxycarbonylgroup.

Substituent set B: an amino group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkyl group substituted with one or morefluorines, a sulfamido group substituted with one or more C₁₋₁₀ alkylgroups, carbamido group substituted with one or more C₁₋₁₀ alkyl groupsand a C₁₋₁₀ alkylcarbonylamino group.

Specific particularly preferable examples of the substituent R³ are aphenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group),furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups(a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolylgroups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a5-quinolyl group, a 6-quinolyl group, a 7-quinoyl group and a 8-quinolylgroup) and isoquinolyl groups (a 1-isoquinolyl group, 3-isoquinolylgroup, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolylgroup, a 7-isoquinolyl group and a 8-isoquinolyl group) optionallysubstituted with one or more of the following substituents.

Substituents: a hydroxyl group, an amino group, a carboxyl group, aphosphonic acid group, a sulfonic acid group, a carbamido group, asulfamido group, a tetrazole group, —CH₂CO₂H, —OCH₂CO₂H, —NHCH₂CO₂H and—CH₂CH₂CO₂H.

Still further, specific particularly preferable examples of thesubstituent R³ are a phenyl group, thienyl groups (a 2-thienyl group anda 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group),pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group),pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridylgroup), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolylgroup and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolylgroup, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolylgroup, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolylgroup) optionally substituted with one or more substituents optionallyselected from substituent set A and with one or more substituentsoptionally selected from substituent set B.

Substituent set A: a hydroxyl group, an amino group, a carboxyl group, aphosphonic acid group, a sulfonic acid group, a carbamido group, asulfamido group, a tetrazole group, —CH₂CO₂H, —OCH₂CO₂H, —NHCH₂CO₂H and—CH₂CH₂CO₂H.

Substituent set B: an amino group, a nitro group, cyano group, a halogenatom, a C₁₋₁₀ alkyl group substituted with one or more fluorine atoms, asulfamido group substituted with one or more C₁₋₁₀ alkyl groups,carbamido group substituted with one or more C₁₋₁₀ alkyl groups and aC₁₋₁₀ alkylcarbonylamino group.

Specific preferable examples of L⁴ are a bond, CH₂, an oxygen atom, asulfur atom, NH, N-Me, N—CHO, CHMe, CMe₂, N—CH₂Ph and the like, andparticularly preferred examples are a single bond, CH₂, an oxygen atom,a sulfur atom, NH, NMe and the like.

Specific preferable examples of X are OH, SH, NH₂, OMe, SMe, NHMe, NHEt,NH—CHO, NH—CH₂Ph, OCH₂Ph, SCH₂Ph, OC(═O)CH₃, SC(═O)CH₃, NC(═O)CH₃ andthe like, and particularly preferred examples are OH, SH, NH₂ and thelike

Specific preferable examples of Y are an oxygen atom, a sulfur atom, NH,N—OH, N—CHO, N-Me, N—CH₂Ph, N-OMe, N—OCH₂Ph an the like, andparticularly preferred examples are an oxygen atom, a sulfur atom, NH,N—OH and the like.

Favorable compounds as the thrombopoietin receptor activator, thepreventive, therapeutic or improving agent for diseases against whichactivation of the thrombopoietin receptor is effective and the plateletincreasing agent of the present invention are as follows.

1) Compounds represented by the formula (1) wherein A is a nitrogenatom, and B is a sulfur atom, tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

2) Compounds represented by the formula (1) wherein A is a nitrogenatom, and B is an oxygen atom, tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

3) Compounds represented by the formula (1) wherein A is a nitrogenatom, and B is NR⁹ (wherein R⁹ is a hydroxyl group, a formyl group, aC₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or alkylamino group, a hydroxyl group, a protected hydroxylgroup, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ arylgroup and the C₂₋₁₄ aryloxy group may be substituted with one or moreC₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with one ormore halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group(the C₂₋₁₄ aryl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a C₁₋₁₀ alkyl group(the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, C₁₋₁₀ alkylcarbonylamino group, an amino group, amono- or alkylamino group, a hydroxyl group, a protected hydroxyl group,a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group) or a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryloxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a C₁₋₁₀ alkyl group(the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aalkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group)),tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

4) Compounds represented by the formula (1) wherein A is CR⁴ (wherein R⁴is a hydrogen atom, a hydroxyl group (the hydroxyl group may besubstituted with a C₂₋₆ alkenyl or a C₂₋₆ alkynyl group), a thiol group(the thiol group may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), anamino group (the amino group may be substituted with one or two C₂₋₆alkenyl groups or one or two C₂₋₆ alkynyl groups), a formyl group, ahalogen atom, a nitro group, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, aC₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and theC₁₋₁₀ alkoxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be, substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), a C₂₋₁₄aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: aC₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may be substituted with one ormore halogen atoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group,an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group,a protected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxygroup), SO₂R⁵, SOR⁵ or COR⁵ (wherein R⁵ is a hydroxyl group, a C₁₋₁₀alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxygroup (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynylgroup and the C₁₋₁₀ alkoxy group may be optionally substituted with oneor more substituents selected from the group consisting of: a carboxylgroup, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxygroup, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, C₁₋₁₀ alkylcarbonylamino group, an aminogroup, a mono- or alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), a C₂₋₁₄aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: aC₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may be substituted with one ormore halogen atoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group,an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group,a protected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxygroup) or NR⁶R⁷ (wherein each of R⁶ and R⁷ is independently a hydrogenatom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (theC₁₋₆ alkyl group may be substituted with one or more halogen atoms) orone or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl groupmay be substituted with one or more halogen atoms), a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group,C₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group), or R⁶ and R⁷ mean, together witheach other, —(CH₂)_(m1)E-(CH₂)_(m2)— (wherein E is an oxygen atom, asulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ is independently ahydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxygroup, a C₂₋₁₄ aryloxy group, a hydroxyl group or a protected hydroxylgroup) or NR⁸ (wherein R⁸ is a hydrogen atom, a hydroxyl group, a formylgroup, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group,a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a alkylcarbonyl group (the C₁₋₁₀ alkyl group, theC₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, theC₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and theC₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group,nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group)), and eachof m1 and m2 is independently an integer of from 0 to 5 provided thatm1+m2 is 3, 4 or 5)))), and B is a oxygen atom, tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

5) Compounds represented by the formula (1) wherein A is CR⁴ (wherein R⁴is a hydrogen atom, a hydroxyl group (the hydroxyl group may besubstituted with a C₂₋₆ alkenyl or a C₂₋₆ alkynyl group), a thiol group(the thiol group may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), anamino group (the amino group may be substituted with one or two C₂₋₆alkenyl groups or one or two C₂₋₆ alkynyl groups), a formyl group, ahalogen atom, a nitro group, cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, aC₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and theC₁₋₁₀ alkoxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, to a C₁₋₁₀ alkylcarbonylamino group, an aminogroup, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group),a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxy group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group), SO₂R⁵, SOR⁵ or COR⁵ (wherein R⁵ is ahydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆alkynyl group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆alkenyl group, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkoxy group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₂₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxygroup may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆alkyl group may be substituted with one or more halogen atoms) or one ormore halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may besubstituted with one or more halogen atoms), a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a carboxyl group, nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group), a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryloxygroup may be optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀alkyl group may be substituted with one or more halogen atoms), a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group) or NR⁶R⁷ (wherein each of R⁶ andR⁷ is independently a hydrogen atom, a hydroxyl group, a formyl group, aC₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₂₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group,nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), or R⁶ andR⁷ mean, together with each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein Eis an oxygen atom, sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ isindependently a hydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group,a C₁₋₁₀ alkoxy group, a C₂₋₁₄ aryloxy group, a hydroxyl group or aprotected hydroxyl group) or NR⁸ (wherein R⁸ is a hydrogen atom, ahydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₂₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (theC₁₋₆ alkyl group may be substituted with one or more halogen atoms) orone or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl groupmay be substituted with one or more halogen atoms), a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group)), and each of m1 and m2 isindependently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or5)))), and B is a sulfur atom, tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

6) Compounds represented by the formula (1) wherein. A is CR⁴ (whereinR⁴ is a hydrogen atom, a hydroxyl group (the hydroxyl group may besubstituted with a C₂₋₆ alkenyl or a C₂₋₆ alkynyl group), a thiol group(the thiol group may be substituted with a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀ alkylcarbonyl group), anamino group (the amino group may be substituted with one or two C₂₋₆alkenyl groups or one or two C₂₋₆ alkynyl groups), a formyl group, ahalogen atom, a nitro group, a cyano group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkylcarbonylamino group, a mono- or di-C₁₋₁₀ alkylamino group, aC₁₋₁₀ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkylcarbonylamino group, the mono- or di-C₁₋₁₀ alkylamino group and theC₁₋₁₀ alkoxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), a C₂₋₁₄aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: aC₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may be substituted with one ormore halogen atoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group,an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group,a protected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxygroup), SO₂R⁵, SOR⁵ or COR⁵ (wherein R⁵ is a hydroxyl group, a C₁₋₁₀alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxygroup (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynylgroup and the C₁₋₁₀ alkoxy group may be optionally substituted with oneor more substituents selected from the group consisting of: a carboxylgroup, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxygroup, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, aC₁₋₁₀ alkoxycarbonyl group, C₁₋₁₀ alkylcarbonylamino group, an aminogroup, a mono- or alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group; anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group), a C₂₋₁₄aryloxy group (the C₂₋₁₄ aryloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: aC₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl group may be substituted with one ormore halogen atoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group,an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group,a protected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxygroup) or NR⁶R⁷ (wherein each of R⁶ and R⁷ is independently a hydrogenatom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄aryloxy group may be substituted with one or more C₁₋₆ alkyl groups (theC₁₋₆ alkyl group may be substituted with one or more halogen, atoms) orone or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄ aryl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀ alkyl groupmay be substituted with one or more halogen atoms), a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy is group), or R⁶ and R⁷ mean, togetherwith each other, —(CH₂)_(m1)-E-(CH₂)_(m2)— (wherein E is an oxygen atom,a sulfur atom, CR²⁶R²⁷ (wherein each of R²⁶ and R²⁷ is independently ahydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₁₄ aryl group, a C₁₋₁₀ alkoxygroup, a C₂₋₁₄ aryloxy group, a hydroxyl group or a protected hydroxylgroup) or NR⁸ (wherein R⁸ is a hydrogen atom, a hydroxyl group, a formylgroup, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group,a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group,the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group,the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and theC₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group)), and eachof m1 and m2 is independently an integer of from 0 to 5 provided thatm1+m2 is 3, 4 or 5)))), and B is NR⁹ (wherein R⁹ is a hydrogen atom, ahydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀ alkylcarbonyl groupmay be optionally substituted with one or more substituents selectedfrom the group consisting of: a carboxyl group, a nitro group, a cyanogroup, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected is hydroxyl group, aC₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and theC₂₋₁₄ aryloxy group may be substituted with one or more C₁₋₆ alkylgroups (the C₁₋₆ alkyl group may be substituted with one or more halogenatoms) or one or more halogen atoms)), a C₂₋₁₄ aryl group (the C₂₋₁₄aryl group may be optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀alkyl group may be substituted with one or more halogen atoms), a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group) or a C₂₋₁₄ aryloxy group (theC₂₋₁₄ aryloxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a C₁₋₁₀ alkyl group(the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group)),tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

7) Compounds represented by the formula (1) according to 4), 5) or 6)wherein A is CR³⁷ (wherein R³⁷ is a hydrogen atom, a hydroxyl group (thehydroxyl group may be substituted with a C₂₋₆ alkenyl or a C₂₋₆ alkynylgroup), a thiol group (the thiol group may be substituted with a C₁₋₁₀alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group or a C₁₋₁₀alkylcarbonyl group), an amino group (the amino group may be substitutedwith one or two C₂₋₆ alkenyl groups or one or two C₂₋₆ alkynyl groups),a formyl group, a halogen atom, a nitro group, a cyano group, a C₁₋₁₀alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylaminogroup, a mono- or di-C₁₋₁₀ alkylamino group (the C₁₋₁₀ alkyl group, theC₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonylamino group andthe mono- or di-C₁₋₁₀ alkylamino group may be substituted with one ormore substituents selected from the group consisting of: a halogen atom,a carboxyl group, a nitro group and a cyano group), SO₂R³⁸, SOR³⁸ orCOR³⁸ (wherein R³⁸ is a hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group; a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group (the C₁₋₁₀alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and theC₁₋₁₀ alkoxy group may be substituted with one or more substituentsselected from the group consisting of: a halogen atom, a carboxyl group,a nitro group and a cyano group), a C₂₋₁₄ aryl group or a C₂₋₁₄ aryloxygroup (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may besubstituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group maybe substituted with one or more halogen atoms) or one or more halogenatoms)), tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof. The terms in the respective substituentsR³⁷ and R³⁸ are the same as those in the respective substituents R¹ toR³⁶.

8) Compounds represented by the formula (1) according to 3) or 6)wherein B is NR³⁹ (wherein R³⁹ is a hydrogen atom, a hydroxyl group, aformyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynylgroup, a C₁₋₂₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkylgroup, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxygroup, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl groupand the C₁₋₁₀ alkylcarbonyl group may be substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, ahalogen atom, a nitro group and a cyano group), a C₂₋₁₄ aryl group or aC₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy groupmay be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkylgroup may be substituted with one or more halogen atoms), a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, a cyanogroup and a halogen atom)), tautomers prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof. The terms in thesubstituent R³⁹ are the same as those in the respective substituents R¹to R³⁶.

9) Compounds represented by the formula (1) according to 1), 2), 3), 4),5), 6), 7) or 8) wherein L¹ is a bond, tautomers prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

10) Compounds represented by the formula (1) according to 1), 2), 3),4), 5), 6), 7), 8) or 9) wherein L² is a bond, tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

11) Compounds represented by the formula (1) according to 1), 2), 3),4), 5), 6), 7), 8), 9) or 10) wherein L³ is NR¹⁹ (wherein R¹⁹ is ahydrogen atom, a hydroxyl group, a formyl group, a C₁₋₁₀ alkyl group, aC₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkoxycarbonyl group, the C₁₋₁₀ alkoxy group and the C₁₋₁₀ alkylcarbonylgroup may be optionally substituted with one or more substituentsselected from the group consisting of: a carboxyl group, a nitro group,a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- ordi-C₁₋₁₀ alkylamino group, a hydroxyl group, protected hydroxyl group, aC₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and theC₂₋₁₄ aryloxy group may be substituted with one or more C₁₋₆ alkylgroups (the C₁₋₆ alkyl group may be substituted with one or more halogenatoms) or one or more halogen atoms)) or a C₂₋₁₄ aryl group (the C₂₋₁₄aryl group may be optionally substituted with one or more substituentsselected from the group consisting of: a C₁₋₁₀ alkyl group (the C₁₋₁₀alkyl group may be substituted with one or more halogen atoms), a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, a nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀alkylamino group, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄aryl group and a C₂₋₁₄ aryloxy group)), tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

12) The compounds according to 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10)wherein L³ is NH, tautomers, prodrugs or pharmaceutically acceptablesalts of the compounds or solvates thereof.

13) The compounds according to 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10)wherein L³ is CH₂, tautomers, prodrugs or pharmaceutically acceptablesalts of the compounds or solvates thereof.

14) The compounds according to 11), 12) or 13) wherein L⁴ is a bond,tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

15) The compounds according to 11), 12) or 13) wherein L⁴ is NR²²(wherein R²² is a hydrogen atom, a hydroxyl group, a formyl group, aC₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀alkylcarbonyloxy group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, C₁₋₁₀ alkylcarbonylamino group, an amino group, amono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)) or a C₂₋₁₄ arylgroup (the C₂₋₁₄ aryl group may be optionally substituted with one ormore substituents selected from the group consisting of: a C₁₋₁₀ alkylgroup (the C₁₋₁₀ alkyl group may be substituted with one or more halogenatoms), a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, C₁₋₁₀ alkylcarbonylamino group, an amino group, amono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group)),tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

16) The compounds according to 11), 12) or 13) wherein L⁴ is NH,tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

17) The compounds according to 11), 12) or 13) wherein L⁴ is CH₂,tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

18) The compounds according to 14), 15), 16) or 17) wherein R² is ahydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynylgroup, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonyloxygroup and the C₁₋₁₀ alkoxycarbonyl group may be optionally substitutedwith one or more substituents selected from the group consisting of: acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcabonyloxygroup, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group,an amino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group,a protected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substitutedwith one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms)), a C₁₋₁₂ aryl group or a C₂₋₁₄ aryloxy group (the C₂₋₁₄ arylgroup and C₂₋₁₄ aryloxy group may be substituted with one or more C₁₋₆alkyl groups (the C₁₋₆ alkyl group may be substituted with one or morehalogen atoms) or one or more halogen atoms), tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

19) The compounds according to 14), 15), 16) or 17) wherein R² is ahydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynylgroup, a C₁₋₃ alkoxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenylgroup, the C₂₋₆ alkynyl group and the C₁₋₃ alkoxy group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a phenyl group anda phenyloxy group (the phenyl group and the phenyloxy group may besubstituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group maybe substituted with one or more halogen atoms) or one or more halogenatoms)), a phenyl group or a phenyloxy group (the phenyl group and thephenyloxy group may be substituted with one or more C₁₋₆ alkyl groups(the C₁₋₆ alkyl group may be substituted with one or more halogen atoms)or one or more halogen atoms), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

20) The compounds according to 14), 15), 16) or 17) wherein. R² is ahydrogen atom, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group or a C₂₋₆alkynyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group and theC₂₋₆ alkynyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group and a protectedhydroxyl group), tautomers, prodrugs or pharmaceutically acceptablesalts of the compounds or solvates thereof.

21) The compounds according to 14), 15), 16) or 17) wherein R² is ahydrogen atom or a C₁₋₆ alkyl group (the C₂₋₆ alkyl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a carboxyl group, a nitro group, a cyano group, ahalogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group and a protected hydroxyl group), tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof.

22) The compounds according to 14), 15), 16) or 17) wherein R² is ahydrogen atom or a C₁₋₃ alkyl group (the C₁₋₃ alkyl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group and a protectedhydroxyl group), tautomers, prodrugs or pharmaceutically acceptablesalts of the compounds or solvates thereof.

23) The compounds according to 18), 19), 20), 21) or 22) wherein R¹ is aC₂₋₁₄ aryl group (the C₂₋₁₄ aryl group may be optionally substitutedwith one or more substituents selected from the group consisting of: ahalogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, ahydroxyl group, a protected hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyloxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group,the C₂₋₆ alkynyl group, C₁₋₁₀ alkoxy group and the C₁₋₁₀ alkylcarbonylgroup may be optionally substituted with one or more substituentsselected from the group consisting of: a carboxyl group, a nitro group,a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a C₂₋₁₄ arylgroup, a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxygroup may be substituted with one or more substituents selected from thegroup consisting of: a C₁₋₆ alkyl group (the C₁₋₆ is alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms), a thiol group and an amino group (the thiol group and the aminogroup may be optionally substituted with one or more substituentsselected from the group consisting of: a formyl group, a C₁₋₁₀ alkylgroup, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group and a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group and the C₁₋₁₀ alkylcarbonyl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a carboxyl group, a nitro group, a cyano group, a halogenatom, a C₁₋₁₀ alkoxy group, a alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, a C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxygroup may be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆alkyl group may be substituted with one or more halogen atoms) or one ormore halogen atoms)))), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

24) The compounds according to 18), 19), 20), 21) or 22) wherein R¹ is aphenyl group, a thienyl group, a furyl group, a pyridazinyl group, apyridyl group, quinolyl group or an isoquinolyl group (the phenyl group,the thienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, acyano group, a hydroxyl group, a protected hydroxyl group, a C₁₋₁₀ alkylgroup, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group,a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonyloxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group,the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkylcarbonylgroup, the C₁₋₁₀ alkylcarbonyloxy group and the C₁₋₁₀ alkoxycarbonylgroup may be optionally substituted with one or more substituentsselected from the group consisting of: a carboxyl group, a nitro group,a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkylcarbonyl group, C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)), a thiol group andan amino (the thiol group and the amino group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a formyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenylgroup, a C₂₋₆ alkynyl group and a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group and theC₁₋₁₀ alkylcarbonyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a carboxyl group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkoxy group, aC₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₂₀alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, an amino group,a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, a protectedhydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group (the C₂₋₁₄aryl group and the C₂₋₁₄ aryloxy group may be substituted with one ormore C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may be substituted with oneor more halogen atoms) or one or more halogen atoms)))), tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof.

25) The compounds according to 18), 19), 20), 21) or 22) wherein R¹ is aphenyl group, a thienyl group, a furyl group, a pyridazinyl group, apyridyl group, a quinolyl group or an isoquinolyl group (the phenylgroup, the thienyl group, the furyl group, the pyridazinyl group, thepyridyl group, the quinolyl group and the isoquinolyl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a halogen atom, a carboxyl group, a nitro group,OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, aC₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₁₀alkoxy group, C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkoxycarbonyl group, aC₁₋₁₀ alkylcarbonyloxy group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenylgroup, the C₂₋₆ alkynyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀alkylcarbonyl group, the C₁₋₁₀ alkoxycarbonyl group and the C₁₋₁₀alkylcarbonyloxy group may be optionally substituted with one or moresubstituents selected from the group consisting of: a halogen atom, acarboxyl group, a nitro group and a cyano group), a C₂₋₁₄ aryl group, aC₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy groupmay be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkylgroup may be substituted with one or more halogen atoms) or one or morehalogen atoms), a thiol group and an amino group (the thiol group andthe amino group may be optionally substituted with one or moresubstituents selected from the group consisting of: a formyl group, aC₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group and aC₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenylgroup, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkylcarbonyl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a halogen atom, a carboxyl group, a nitro group, acyano group, a hydroxyl group and a protected hydroxyl group))),tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

26) The compounds according to 18), 19), 20), 21) or 22) wherein R¹ is aphenyl group (the phenyl group may be optionally substituted with one ormore substituents selected from the group consisting of: a halogen atom,a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group,a protected hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, aC₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group (the C₁₋₁₀alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀alkoxy group, the C₁₋₁₀ alkylcarbonyl group, the C₁₋₁₀ alkoxycarbonylgroup and the C₁₋₁₀ alkylcarbonyloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: acarboxyl group, a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, a alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonylamino group, anamino group, a mono- or di-C₁₋₁₀ alkylamino group, a hydroxyl group, aprotected hydroxyl group, a C₂₋₁₄ aryl group and a C₂₋₁₄ aryloxy group(the C₂₋₁₄ aryl group and the C₂₋₁₄ aryloxy group may be substitutedwith one or more C₁₋₆ alkyl groups (the C₁₋₆ alkyl group may besubstituted with one or more halogen atoms) or one or more halogenatoms)), a thiol group and an amino group (the thiol group and the aminogroup may be optionally substituted with one or more substituentsselected from the group consisting of: a formyl group, a C₁₋₁₀ alkylgroup, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group and a C₁₋₁₀alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenyl group, theC₂₋₆ alkynyl group and the C₁₋₁₀ alkylcarbonyl group may be optionallysubstituted with one or more substituents selected from the groupconsisting of: a carboxyl group, a nitro group, a cyano group, a halogenatom, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀alkylcarbonyloxy group, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀alkylcarbonylamino group, an amino group, a mono- or di-C₁₋₁₀ alkylaminogroup, a hydroxyl group, a protected hydroxyl group, C₂₋₁₄ aryl groupand a C₂₋₁₄ aryloxy group (the C₂₋₁₄ group and the C₂₋₁₄ aryloxy groupmay be substituted with one or more C₁₋₆ alkyl groups (the C₁₋₆ alkylgroup may be substituted with one or more halogen atoms) or one or morehalogen atoms)))), tautomers, prodrugs or pharmaceutically acceptablesalts of the compounds or solvates thereof.

27) The compounds according to 18), 19), 20), 21) or 22) wherein R¹ is aphenyl group (the phenyl group may be optionally substituted with one ormore substituents selected from the group consisting of: a halogen atom,a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group,a protected hydroxyl group, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, aC₂₋₆ alkynyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkylcarbonyl group, aC₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkylcarbonyloxy group (the C₁₋₁₀alkyl group, the C₂₋₆ alkenyl group, the C₂₋₆ alkynyl group, the C₁₋₁₀alkoxy group, the C₁₋₁₀ alkylcarbonyl group, the C₁₋₁₀ alkoxycarbonylgroup and the C₁₋₁₀ alkylcarbonyloxy group may be optionally substitutedwith one or more substituents selected from the group consisting of: ahalogen atom, a carboxyl group, a nitro group and a cyano group), aC₂₋₁₄ aryl group, a C₂₋₁₄ aryloxy group (the C₂₋₁₄ aryl group and theC₂₋₁₄ aryloxy group may be substituted with one or more C₁₋₆ alkylgroups (the C₁₋₆ alkyl group may be substituted with one or more halogenatoms) or one or more halogen atoms), a thiol group and an amino group(the thiol group and the amino group may be optionally substituted withone or more substituents selected from the group consisting of: a formylgroup, a C₁₋₁₀ alkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl groupand a C₁₋₁₀ alkylcarbonyl group (the C₁₋₁₀ alkyl group, the C₂₋₆ alkenylgroup, the C₂₋₆ alkynyl group and the C₁₋₁₀ alkylcarbonyl group may beoptionally substituted with one or more substituents selected from thegroup consisting of: a halogen atom, a carboxyl group, a nitro group, acyano group, a hydroxyl group and a protected hydroxyl group))),tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

28) The compounds according to 23), 24), 25), 26) or 27) wherein Y is anoxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts ofthe compounds or solvates thereof.

29) The compounds according to 23), 24), 25), 26) or 27) wherein Y is asulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts ofthe compounds or solvates thereof.

30) The compounds according to 28) or 29) wherein X is a hydroxyl group,tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

31) The compounds according to 28), 29) or 30) wherein R³ is a C₂₋₁₄aryl group (the C₂₋₁₄ aryl group may be optionally substituted with oneor more substituents selected from the group consisting of: a hydroxylgroup, an amino group, a carboxyl group, a phosphonic acid group, asulfonic acid group, a carbamido group, a sulfamido group, ahydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkyl groupsubstituted with one or more fluorine atoms, a sulfamido groupsubstituted with one or more C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or more C₁₋₁₀ alkyl groups, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkyl group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkylcarbonylamino groupand a mono- or di-C₁₋₁₀ alkylamino group (the C₁₋₁₀ alkoxycarbonylgroup, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkyl group, the C₁₋₁₀alkylcarbonyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkylcarbonylamino group and the mono- or di-C₁₋₁₀ alkylamino group maybe optionally substituted with one or more substituents selected fromthe group consisting of: a hydroxyl group, an amino group, a mono- ordi-C₁₋₁₀ alkylamino group, a carboxyl group, a nitro group, a cyanogroup and a halogen atom)), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

32) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl, a furyl group, a pyridazinyl group, a pyridyl group, aquinolyl group or an isoquinolyl group (the phenyl group, the thienyl,the furyl group, the pyridazinyl group, the pyridyl group, the quinolylgroup and the isoquinolyl group may be optionally substituted with oneor more substituents selected from the group consisting of: a hydroxylgroup, an amino group, a carboxyl group, a phosphonic acid group, asulfonic acid group, a carbamido group, a sulfamido group, ahydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, anitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkyl groupsubstituted with one or more fluorine atoms, a sulfamido groupsubstituted with one or more C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or more C₁₋₁₀ alkyl groups, a C₁₋₁₀ alkoxycarbonylgroup, a C₁₋₁₀ alkoxy group, a C₁₋₁₀ alkyl group, a C₁₋₁₀ alkylcarbonylgroup, a C₁₋₁₀ alkylcarbonyloxy group, a C₁₋₁₀ alkylcarbonylamino groupand a mono- or di-C₁₋₁₀ alkylamino group (the C₁₋₁₀ alkoxycarbonylgroup, the C₁₋₁₀ alkoxy group, the C₁₋₁₀ alkyl group, the C₁₋₁₀alkylcarbonyl group, the C₁₋₁₀ alkylcarbonyloxy group, the C₁₋₁₀alkylcarbonylamino group and the mono- or di-C₁₋₁₀ alkylamino group maybe optionally substituted with one or more substituents selected fromthe group consisting of: a hydroxyl group, an amino group, a mono- ordi-C₁₋₁₀ alkylamino group, a carboxyl group, a nitro group, a cyanogroup and a halogen atom)), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

33) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup (the phenyl group may be optionally substituted with one or moresubstituents selected from the group consisting of: a hydroxyl group, anamino group, a carboxyl group, a phosphonic acid group, a sulfonic acidgroup, a carbamido group, a sulfamido group, a hydroxycarbamido group,hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group,a halogen atom, a C₂₋₁₀ alkyl group substituted with one or morefluorine atoms, a sulfamido group substituted with one or more C₁₋₁₀alkyl groups, a carbamido group substituted with one or more C₁₋₁₀ alkylgroups, a C₁₋₁₀ alkoxycarbonyl group, a C₁₋₁₀ alkoxy group, a C₁₋₁₀alkyl group, a C₁₋₁₀ alkylcarbonyl group, a C₁₋₁₀ alkylcarbonyloxygroup, C₁₋₁₀ alkylcarbonylamino group and a mono- or di-C₁₋₁₀ alkylaminogroup (the C₁₋₁₀ alkoxycarbonyl group, the C₁₋₁₀ alkoxy group, the C₁₋₁₀alkyl group, the C₁₋₁₀ alkylcarbonyl group, the C₁₋₁₀ alkylcarbonyloxygroup, the C₁₋₁₀ alkylcarbonylamino group and the mono- or di-C₁₋₁₀alkylamino group may be optionally substituted with one or moresubstituents selected from the group consisting of: a hydroxyl group, anamino group, a mono- or di-C₁₋₁₀ alkylamino group, a carboxyl group, anitro group, a cyano group and a halogen atom)), tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

34) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are optionallysubstituted with one or more substituents selected from the groupconsisting of: a carboxyl group, a phosphonic acid group, a sulfonicacid group, a carbamido group, a sulfamido group, a hydroxycarbamidogroup, a hydroxysulfamido group, a tetrazole group, a nitro group, acyano group, a halogen atom, a C₁₋₁₀ alkyl group substituted with one ormore fluorine atoms, a sulfamido group substituted with one or moreC₁₋₁₀ alkyl groups, a carbamido group substituted with one or more C₁₋₁₀alkyl groups and a C₁₋₁₀ alkylcarbonylamino group), tautomers, prodrugsor pharmaceutically acceptable salts of the compounds or solvatesthereof.

35) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup (the phenyl group is optionally substituted with a carboxyl group,a phosphonic acid group, a sulfonic acid group, a carbamido group, asulfamido group, a hydroxycarbamido group, a hydroxysulfamido group or atetrazole group), tautomers, prodrugs or pharmaceutically acceptablesalts of the compounds or solvates thereof.

36) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are optionallysubstituted with a carboxyl group, a phosphonic acid group, a sulfonicacid group or a tetrazole group), tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

37) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup (the phenyl group is optionally substituted with a carboxyl group,a phosphonic acid group, a sulfonic acid group or a tetrazole group),tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

38) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are substituted witha carboxyl group), tautomers, prodrugs or pharmaceutically acceptablesalts of the compounds or solvates thereof.

39) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with a carboxyl group, tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

40) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are optionallysubstituted with a sulfonic acid group), tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

41) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with a sulfonic acid group, tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

42) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a pyridyl group, a thienyl group, a furyl group, a pyridazinylgroup, a 1,3,4-oxadiazole group, a 1,3,4-thiadiazole group, a1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a 1,2,5-oxadiazolegroup, a 1,2,5-thiadiazole group, a 1,2-oxazole group, a 1,2-thiazolegroup, a quinolyl group or an isoquinolyl group (the phenyl group, thepyridyl group, the thienyl group, the furyl group, the pyridazinylgroup, the 1,3,4-oxadiazole group, the 1,3,4-thiadiazole group, the1,2,4-oxadiazole group, the 1,2,4-thiadiazole group, the1,2,5-oxadiazole group, the 1,2,5-thiadiazole group, the 1,2-oxazolegroup, the 1,2-thiazole group, the quinolyl group and the isoquinolylgroup are optionally substituted with one or more hydroxyl groups),tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

43) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a pyridyl group, a thienyl group, a furyl group, a pyridazinylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thepyridyl group, the thienyl group, the furyl group, the pyridazinylgroup, the quinolyl group and the isoquinolyl group are optionallysubstituted with an azole group optionally substituted with one or morehydroxyl groups (the azole group is a 1,3,4-oxadiazole group, a1,3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazolegroup, a 1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a1,2-oxazole group or a 1,2-thiazole group)), tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

44) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are optionallysubstituted with one or more —CH₂CO₂H groups), tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

45) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with one or more —CH₂CO₂H groups, tautomers, prodrugsor pharmaceutically acceptable salts of the compounds or solvatesthereof.

46) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group, (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are substituted withone or more —OCH₂CO₂H groups), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

47) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with one or more —OCH₂CO₂H groups, tautomers, prodrugsor pharmaceutically acceptable salts of the compounds or solvatesthereof.

48) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are substituted withone or more —NHCH₂CO₂H groups), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

49) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with one or more —NHCH₂CO₂H groups, tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof.

50) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are substituted withone or more —CH₂CH₂CO₂H groups), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

51) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with one or more —CH₂CH₂CO₂H groups, tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof.

52) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup (the phenyl group is optionally substituted with one or moresubstituents optionally selected from the group consisting of:

a carboxyl group, a phosphonic acid group, a sulfonic acid group, acarbamido group, a sulfamido group, a hydroxycarbamido group, ahydroxysulfamido group and a tetrazole group

and a substituent optionally selected from the group consisting of:

a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkyl groupsubstituted with one or more fluorine atoms, a sulfamido groupsubstituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

53) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are optionallysubstituted with one or more substituents selected from the groupconsisting of:

a carboxyl group, a phosphonic acid group, a sulfonic acid group and atetrazole group

and one or more substituents optionally selected from the groupconsisting of:

a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkyl groupsubstituted with one or more fluorine atoms, a sulfamido groupsubstituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

54) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup (the phenyl group is optionally substituted with one or moresubstituents selected from the group consisting of:

a carboxyl group, a phosphonic acid group, a sulfonic acid group and atetrazole group

and one or more substituents optionally selected from the groupconsisting of:

a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkyl groupsubstituted with one or more fluorine atoms, a sulfamido groupsubstituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

55) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are substituted witha carboxyl group and a substituent optionally selected from a nitrogroup, a cyano group, a halogen atom, a C₁₋₁₀ alkyl group substitutedwith one or more fluorine atoms, a sulfamido group substituted with oneor two C₁₋₁₀ alkyl groups, a carbamido group substituted with one or twoC₁₋₁₀ alkyl groups and a C₁₋₁₀ alkylcarbonylamino group), tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof.

56) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with a carboxyl group and a substituent optionallyselected from a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkyl group substituted with one or more fluorine atoms, a sulfamidogroup substituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group, tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

57) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are optionallysubstituted with a sulfonic acid group and a substituent optionallyselected from a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkyl group substituted with one or more fluorine atoms, a sulfamidogroup substituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

58) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with a sulfonic acid group and a substituentoptionally selected from a nitro group, a cyano group, a halogen atom, aC₁₋₁₀ alkyl group substituted with one or more fluorine atoms, sulfamidogroup substituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group, tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

59) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a pyridyl group, a thienyl group, a furyl group, a pyridazinylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thepyridyl group, the thienyl group, the furyl group, the pyridazinylgroup, the quinolyl group and the isoquinolyl group are optionallysubstituted with one or more hydroxyl groups and a substituentoptionally selected from a nitro group, a cyano group, a halogen atom, aC₁₋₁₀ alkyl group substituted with one or more fluorine atoms, asulfamido group substituted with one or two C₁₋₁₀ alkyl groups, acarbamido group substituted with one or two C₁₋₁₀ alkyl groups and aC₁₋₁₀ alkylcarbonylamino group), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

60) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are optionallysubstituted with a —CH₂CO₂H group and a substituent optionally selectedfrom a nitro group, a cyano group, a halogen atom, a C₁₋₁₀ alkyl groupsubstituted with one or more fluorine atoms, a sulfamido groupsubstituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group), tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

61) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with a —CH₂CO₂H group and a substituent optionallyselected from a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkyl group substituted with one or more fluorine atoms, a sulfamidogroup substituted with one or two C₁₋₁₀ alkyl groups, carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group, tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

62) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are substituted witha —OCH₂CO₂H group and a substituent optionally selected from a nitrogroup, a cyano group, a halogen atom, a C₁₋₁₀ alkyl group substitutedwith one or more fluorine atoms, a sulfamido group substituted with oneor two C₁₀ alkyl groups, a carbamido group substituted with one or twoC₁₋₁₀ alkyl groups and a C₁₋₁₀ alkylcarbonylamino group), tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof.

63) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with a —OCH₂CO₂H group and a substituent optionallyselected from a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkyl group substituted with one or more fluorine atoms, a sulfamidogroup substituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group, tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

64) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are substituted witha —NHCH₂CO₂H group and a substituent optionally selected from a nitrogroup, a cyano group, a halogen atom, a C₁₋₁₀ alkyl group substitutedwith one or more fluorine atoms, a sulfamido group substituted with oneor two C₁₋₁₀ alkyl groups, a carbamido group substituted with one or twoC₁₋₁₀ alkyl groups and a C₁₋₁₀ alkylcarbonylamino group), tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof.

65) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with a —NHCH₂CO₂H group and a substituent optionallyselected from a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkyl group substituted with one or more fluorine atoms, a sulfamidogroup substituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group, tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

66) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup, a thienyl group, a furyl group, a pyridazinyl group, a pyridylgroup, a quinolyl group or an isoquinolyl group (the phenyl group, thethienyl group, the furyl group, the pyridazinyl group, the pyridylgroup, the quinolyl group and the isoquinolyl group are substituted witha —CH₂CH₂CO₂H group and a substituent optionally selected from a nitrogroup, a cyano group, a halogen atom, a C₁₋₁₀ alkyl group substitutedwith one or more fluorine atoms, a sulfamido group substituted with oneor two C₁₋₁₀ alkyl groups, a carbamido group substituted with one or twoC₁₋₁₀ alkyl groups and a C₁₋₁₀ alkylcarbonylamino group), tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof.

67) The compounds according to 28), 29) or 30) wherein R³ is a phenylgroup substituted with a —CH₂CH₂CO₂H group and a substituent optionallyselected from a nitro group, a cyano group, a halogen atom, a C₁₋₁₀alkyl group substituted with one or more fluorine atoms, a sulfamidogroup substituted with one or two C₁₋₁₀ alkyl groups, a carbamido groupsubstituted with one or two C₁₋₁₀ alkyl groups and a C₁₋₁₀alkylcarbonylamino group, tautomers, prodrugs or pharmaceuticallyacceptable salts of the compounds or solvates thereof.

68) The compounds wherein A, B, R¹, L¹, R², L², L³, L⁴, R³ and X are anyof the following combinations in Table 1, tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.

The symbols in Table 1 denote the flowing substituents.

TABLE 1 No A B R¹ L¹ R² L² L³ Y L⁴ R³ X 1 N NMe Q1a a bond Me a bond NHS NH Q3a OH 2 N NMe Q1a a bond Me a bond NH S NH Q3b OH 3 N NMe Q1a abond Me a bond NH S NH Q3c OH 4 N NMe Q1a a bond Me a bond NH S a bondQ3a OH 5 N NMe Q1a a bond Me a bond NH S a bond Q3b OH 6 N NMe Q1a abond Me a bond NH S a bond Q3c OH 7 N NMe Q1a a bond Me a bond NH O NHQ3a OH 8 N NMe Q1a a bond Me a bond NH O NH Q3b OH 9 N NMe Q1a a bond Mea bond NH O NH Q3c OH 10 N NMe Q1a a bond Me a bond NH O a bond Q3a OH11 N NMe Q1a a bond Me a bond NH O a bond Q3b OH 12 N NMe Q1a a bond Mea bond NH O a bond Q3c OH 13 N NMe Q1a a bond H a bond NH S NH Q3a OH 14N NMe Q1a a bond H a bond NH S NH Q3b OH 15 N NMe Q1a a bond H a bond NHS NH Q3c OH 16 N NMe Q1a a bond H a bond NH S a bond Q3a OH 17 N NMe Q1aa bond H a bond NH S a bond Q3b OH 18 N NMe Q1a a bond H a bond NH S abond Q3c OH 19 N NMe Q1a a bond H a bond NH O NH Q3a OH 20 N NMe Q1a abond H a bond NH O NH Q3b OH 21 N NMe Q1a a bond H a bond NH O NH Q3c OH22 N NMe Q1a a bond H a bond NH O a bond Q3a OH 23 N NMe Q1a a bond H abond NH O a bond Q3b OH 24 N NMe Q1a a bond H a bond NH O a bond Q3c OH25 N NMe Q1b a bond Me a bond NH S NH Q3a OH 26 N NMe Q1b a bond Me abond NH S NH Q3b OH 27 N NMe Q1b a bond Me a bond NH S NH Q3c OH 28 NNMe Q1b a bond Me a bond NH S a bond Q3a OH 29 N NMe Q1b a bond Me abond NH S a bond Q3b OH 30 N NMe Q1b a bond Me a bond NH S a bond Q3c OH31 N NMe Q1b a bond Me a bond NH O NH Q3a OH 32 N NMe Q1b a bond Me abond NH O NH Q3b OH 33 N NMe Q1b a bond Me a bond NH O NH Q3c OH 34 NNMe Q1b a bond Me a bond NH O a bond Q3a OH 35 N NMe Q1b a bond Me abond NH O a bond Q3b OH 36 N NMe Q1b a bond Me a bond NH O a bond Q3c OH37 N NMe Q1b a bond H a bond NH S NH Q3a OH 38 N NMe Q1b a bond H a bondNH S NH Q3b OH 39 N NMe Q1b a bond H a bond NH S NH Q3c OH 40 N NMe Q1ba bond H a bond NH S a bond Q3a OH 41 N NMe Q1b a bond H a bond NH S abond Q3b OH 42 N NMe Q1b a bond H a bond NH S a bond Q3c OH 43 N NMe Q1ba bond H a bond NH O NH Q3a OH 44 N NMe Q1b a bond H a bond NH O NH Q3bOH 45 N NMe Q1b a bond H a bond NH O NH Q3c OH 46 N NMe Q1b a bond H abond NH O a bond Q3a OH 47 N NMe Q1b a bond H a bond NH O a bond Q3b OH48 N NMe Q1b a bond H a bond NH O a bond Q3c OH 49 N NMe Q1c a bond Me abond NH S NH Q3a OH 50 N NMe Q1c a bond Me a bond NH S NH Q3b OH 51 NNMe Q1c a bond Me a bond NH S NH Q3c OH 52 N NMe Q1c a bond Me a bond NHS a bond Q3a OH 53 N NMe Q1c a bond Me a bond NH S a bond Q3b OH 54 NNMe Q1c a bond Me a bond NH S a bond Q3c OH 55 N NMe Q1c a bond Me abond NH O NH Q3a OH 56 N NMe Q1c a bond Me a bond NH O NH Q3b OH 57 NNMe Q1c a bond Me a bond NH O NH Q3c OH 58 N NMe Q1c a bond Me a bond NHO a bond Q3a OH 59 N NMe Q1c a bond Me a bond NH O a bond Q3b OH 60 NNMe Q1c a bond Me a bond NH O a bond Q3c OH 61 N NMe Q1c a bond H a bondNH S NH Q3a OH 62 N NMe Q1c a bond H a bond NH S NH Q3b OH 63 N NMe Q1ca bond H a bond NH S NH Q3c OH 64 N NMe Q1c a bond H a bond NH S a bondQ3a OH 65 N NMe Q1c a bond H a bond NH S a bond Q3b OH 66 N NMe Q1c abond H a bond NH S a bond Q3c OH 67 N NMe Q1c a bond H a bond NH O NHQ3a OH 68 N NMe Q1c a bond H a bond NH O NH Q3b OH 69 N NMe Q1c a bond Ha bond NH O NH Q3c OH 70 N NMe Q1c a bond H a bond NH O a bond Q3a OH 71N NMe Q1c a bond H a bond NH O a bond Q3b OH 72 N NMe Q1c a bond H abond NH O a bond Q3c OH 73 N NMe Q1d a bond Me a bond NH S NH Q3a OH 74N NMe Q1d a bond Me a bond NH S NH Q3b OH 75 N NMe Q1d a bond Me a bondNH S NH Q3c OH 76 N NMe Q1d a bond Me a bond NH S a bond Q3a OH 77 N NMeQ1d a bond Me a bond NH S a bond Q3b OH 78 N NMe Q1d a bond Me a bond NHS a bond Q3c OH 79 N NMe Q1d a bond Me a bond NH O NH Q3a OH 80 N NMeQ1d a bond Me a bond NH O NH Q3b OH 81 N NMe Q1d a bond Me a bond NH ONH Q3c OH 82 N NMe Q1d a bond Me a bond NH O a bond Q3a OH 83 N NMe Q1da bond Me a bond NH O a bond Q3b OH 84 N NMe Q1d a bond Me a bond NH O abond Q3c OH 85 N NMe Q1d a bond H a bond NH S NH Q3a OH 86 N NMe Q1d abond H a bond NH S NH Q3b OH 87 N NMe Q1d a bond H a bond NH S NH Q3c OH88 N NMe Q1d a bond H a bond NH S a bond Q3a OH 89 N NMe Q1d a bond H abond NH S a bond Q3b OH 90 N NMe Q1d a bond H a bond NH S a bond Q3c OH91 N NMe Q1d a bond H a bond NH O NH Q3a OH 92 N NMe Q1d a bond H a bondNH O NH Q3b OH 93 N NMe Q1d a bond H a bond NH O NH Q3c OH 94 N NMe Q1da bond H a bond NH O a bond Q3a OH 95 N NMe Q1d a bond H a bond NH O abond Q3b OH 96 N NMe Q1d a bond H a bond NH O a bond Q3c OH 97 N NMe Q1ea bond Me a bond NH S NH Q3a OH 98 N NMe Q1e a bond Me a bond NH S NHQ3b OH 99 N NMe Q1e a bond Me a bond NH S NH Q3c OH 100 N NMe Q1e a bondMe a bond NH S a bond Q3a OH 101 N NMe Q1e a bond Me a bond NH S a bondQ3b OH 102 N NMe Q1e a bond Me a bond NH S a bond Q3c OH 103 N NMe Q1e abond Me a bond NH O NH Q3a OH 104 N NMe Q1e a bond Me a bond NH O NH Q3bOH 105 N NMe Q1e a bond Me a bond NH O NH Q3c OH 106 N NMe Q1e a bond Mea bond NH O a bond Q3a OH 107 N NMe Q1e a bond Me a bond NH O a bond Q3bOH 108 N NMe Q1e a bond Me a bond NH O a bond Q3c OH 109 N NMe Q1e abond H a bond NH S NH Q3a OH 110 N NMe Q1e a bond H a bond NH S NH Q3bOH 111 N NMe Q1e a bond H a bond NH S NH Q3c OH 112 N NMe Q1e a bond H abond NH S a bond Q3a OH 113 N NMe Q1e a bond H a bond NH S a bond Q3b OH114 N NMe Q1e a bond H a bond NH S a bond Q3c OH 115 N NMe Q1e a bond Ha bond NH O NH Q3a OH 116 N NMe Q1e a bond H a bond NH O NH Q3b OH 117 NNMe Q1e a bond H a bond NH O NH Q3c OH 118 N NMe Q1e a bond H a bond NHO a bond Q3a OH 119 N NMe Q1e a bond H a bond NH O a bond Q3b OH 120 NNMe Q1e a bond H a bond NH O a bond Q3c OH 121 N NMe Q1f a bond Me abond NH S NH Q3a OH 122 N NMe Q1f a bond Me a bond NH S NH Q3b OH 123 NNMe Q1f a bond Me a bond NH S NH Q3c OH 124 N NMe Q1f a bond Me a bondNH S a bond Q3a OH 125 N NMe Q1f a bond Me a bond NH S a bond Q3b OH 126N NMe Q1f a bond Me a bond NH S a bond Q3c OH 127 N NMe Q1f a bond Me abond NH O NH Q3a OH 128 N NMe Q1f a bond Me a bond NH O NH Q3b OH 129 NNMe Q1f a bond Me a bond NH O NH Q3c OH 130 N NMe Q1f a bond Me a bondNH O a bond Q3a OH 131 N NMe Q1f a bond Me a bond NH O a bond Q3b OH 132N NMe Q1f a bond Me a bond NH O a bond Q3c OH 133 N NMe Q1f a bond H abond NH S NH Q3a OH 134 N NMe Q1f a bond H a bond NH S NH Q3b OH 135 NNMe Q1f a bond H a bond NH S NH Q3c OH 136 N NMe Q1f a bond H a bond NHS a bond Q3a OH 137 N NMe Q1f a bond H a bond NH S a bond Q3b OH 138 NNMe Q1f a bond H a bond NH S a bond Q3c OH 139 N NMe Q1f a bond H a bondNH O NH Q3a OH 140 N NMe Q1f a bond H a bond NH O NH Q3b OH 141 N NMeQ1f a bond H a bond NH O NH Q3c OH 142 N NMe Q1f a bond H a bond NH O abond Q3a OH 143 N NMe Q1f a bond H a bond NH O a bond Q3b OH 144 N NMeQ1f a bond H a bond NH O a bond Q3c OH 145 N NMe Q1g a bond Me a bond NHS NH Q3a OH 146 N NMe Q1g a bond Me a bond NH S NH Q3b OH 147 N NMe Q1ga bond Me a bond NH S NH Q3c OH 148 N NMe Q1g a bond Me a bond NH S abond Q3a OH 149 N NMe Q1g a bond Me a bond NH S a bond Q3b OH 150 N NMeQ1g a bond Me a bond NH S a bond Q3c OH 151 N NMe Q1g a bond Me a bondNH O NH Q3a OH 152 N NMe Q1g a bond Me a bond NH O NH Q3b OH 153 N NMeQ1g a bond Me a bond NH O NH Q3c OH 154 N NMe Q1g a bond Me a bond NH Oa bond Q3a OH 155 N NMe Q1g a bond Me a bond NH O a bond Q3b OH 156 NNMe Q1g a bond Me a bond NH O a bond Q3c OH 157 N NMe Q1g a bond H abond NH S NH Q3a OH 158 N NMe Q1g a bond H a bond NH S NH Q3b OH 159 NNMe Q1g a bond H a bond NH S NH Q3c OH 160 N NMe Q1g a bond H a bond NHS a bond Q3a OH 161 N NMe Q1g a bond H a bond NH S a bond Q3b OH 162 NNMe Q1g a bond H a bond NH S a bond Q3c OH 163 N NMe Q1g a bond H a bondNH O NH Q3a OH 164 N NMe Q1g a bond H a bond NH O NH Q3b OH 165 N NMeQ1g a bond H a bond NH O NH Q3c OH 166 N NMe Q1g a bond H a bond NH O abond Q3a OH 167 N NMe Q1g a bond H a bond NH O a bond Q3b OH 168 N NMeQ1g a bond H a bond NH O a bond Q3c OH 169 N NMe Q1h a bond Me a bond NHS NH Q3a OH 170 N NMe Q1h a bond Me a bond NH S NH Q3b OH 171 N NMe Q1ha bond Me a bond NH S NH Q3c OH 172 N NMe Q1h a bond Me a bond NH S abond Q3a OH 173 N NMe Q1h a bond Me a bond NH S a bond Q3b OH 174 N NMeQ1h a bond Me a bond NH S a bond Q3c OH 175 N NMe Q1h a bond Me a bondNH O NH Q3a OH 176 N NMe Q1h a bond Me a bond NH O NH Q3b OH 177 N NMeQ1h a bond Me a bond NH O NH Q3c OH 178 N NMe Q1h a bond Me a bond NH Oa bond Q3a OH 179 N NMe Q1h a bond Me a bond NH O a bond Q3b OH 180 NNMe Q1h a bond Me a bond NH O a bond Q3c OH 181 N NMe Q1h a bond H abond NH S NH Q3a OH 182 N NMe Q1h a bond H a bond NH S NH Q3b OH 183 NNMe Q1h a bond H a bond NH S NH Q3c OH 184 N NMe Q1h a bond H a bond NHS a bond Q3a OH 185 N NMe Q1h a bond H a bond NH S a bond Q3b OH 186 NNMe Q1h a bond H a bond NH S a bond Q3c OH 187 N NMe Q1h a bond H a bondNH O NH Q3a OH 188 N NMe Q1h a bond H a bond NH O NH Q3b OH 189 N NMeQ1h a bond H a bond NH O NH Q3c OH 190 N NMe Q1h a bond H a bond NH O abond Q3a OH 191 N NMe Q1h a bond H a bond NH O a bond Q3b OH 192 N NMeQ1h a bond H a bond NH O a bond Q3c OH 193 N NMe Q1i a bond Me a bond NHS NH Q3a OH 194 N NMe Q1i a bond Me a bond NH S NH Q3b OH 195 N NMe Q1ia bond Me a bond NH S NH Q3c OH 196 N NMe Q1i a bond Me a bond NH S abond Q3a OH 197 N NMe Q1i a bond Me a bond NH S a bond Q3b OH 198 N NMeQ1i a bond Me a bond NH S a bond Q3c OH 199 N NMe Q1i a bond Me a bondNH O NH Q3a OH 200 N NMe Q1i a bond Me a bond NH O NH Q3b OH 201 N NMeQ1i a bond Me a bond NH O NH Q3c OH 202 N NMe Q1i a bond Me a bond NH Oa bond Q3a OH 203 N NMe Q1i a bond Me a bond NH O a bond Q3b OH 204 NNMe Q1i a bond Me a bond NH O a bond Q3c OH 205 N NMe Q1i a bond H abond NH S NH Q3a OH 206 N NMe Q1i a bond H a bond NH S NH Q3b OH 207 NNMe Q1i a bond H a bond NH S NH Q3c OH 208 N NMe Q1i a bond H a bond NHS a bond Q3a OH 209 N NMe Q1i a bond H a bond NH S a bond Q3b OH 210 NNMe Q1i a bond H a bond NH S a bond Q3c OH 211 N NMe Q1i a bond H a bondNH O NH Q3a OH 212 N NMe Q1i a bond H a bond NH O NH Q3b OH 213 N NMeQ1i a bond H a bond NH O NH Q3c OH 214 N NMe Q1i a bond H a bond NH O abond Q3a OH 215 N NMe Q1i a bond H a bond NH O a bond Q3b OH 216 N NMeQ1i a bond H a bond NH O a bond Q3c OH 217 N NMe Q1j a bond Me a bond NHS NH Q3a OH 218 N NMe Q1j a bond Me a bond NH S NH Q3b OH 219 N NMe Q1ja bond Me a bond NH S NH Q3c OH 220 N NMe Q1j a bond Me a bond NH S abond Q3a OH 221 N NMe Q1j a bond Me a bond NH S a bond Q3b OH 222 N NMeQ1j a bond Me a bond NH S a bond Q3c OH 223 N NMe Q1j a bond Me a bondNH O NH Q3a OH 224 N NMe Q1j a bond Me a bond NH O NH Q3b OH 225 N NMeQ1j a bond Me a bond NH O NH Q3c OH 226 N NMe Q1j a bond Me a bond NH Oa bond Q3a OH 227 N NMe Q1j a bond Me a bond NH O a bond Q3b OH 228 NNMe Q1j a bond Me a bond NH O a bond Q3c OH 229 N NMe Q1j a bond H abond NH S NH Q3a OH 230 N NMe Q1j a bond H a bond NH S NH Q3b OH 231 NNMe Q1j a bond H a bond NH S NH Q3c OH 232 N NMe Q1j a bond H a bond NHS a bond Q3a OH 233 N NMe Q1j a bond H a bond NH S a bond Q3b OH 234 NNMe Q1j a bond H a bond NH S a bond Q3c OH 235 N NMe Q1j a bond H a bondNH O NH Q3a OH 236 N NMe Q1j a bond H a bond NH O NH Q3b OH 237 N NMeQ1j a bond H a bond NH O NH Q3c OH 238 N NMe Q1j a bond H a bond NH O abond Q3a OH 239 N NMe Q1j a bond H a bond NH O a bond Q3b OH 240 N NMeQ1j a bond H a bond NH O a bond Q3c OH 241 N NEt Q1a a bond Me a bond NHS NH Q3a OH 242 N NEt Q1a a bond Me a bond NH S NH Q3b OH 243 N NEt Q1aa bond Me a bond NH S NH Q3c OH 244 N NEt Q1a a bond Me a bond NH S abond Q3a OH 245 N NEt Q1a a bond Me a bond NH S a bond Q3b OH 246 N NEtQ1a a bond Me a bond NH S a bond Q3c OH 247 N NEt Q1a a bond Me a bondNH O NH Q3a OH 248 N NEt Q1a a bond Me a bond NH O NH Q3b OH 249 N NEtQ1a a bond Me a bond NH O NH Q3c OH 250 N NEt Q1a a bond Me a bond NH Oa bond Q3a OH 251 N NEt Q1a a bond Me a bond NH O a bond Q3b OH 252 NNEt Q1a a bond Me a bond NH O a bond Q3c OH 253 N NEt Q1a a bond H abond NH S NH Q3a OH 254 N NEt Q1a a bond H a bond NH S NH Q3b OH 255 NNEt Q1a a bond H a bond NH S NH Q3c OH 256 N NEt Q1a a bond H a bond NHS a bond Q3a OH 257 N NEt Q1a a bond H a bond NH S a bond Q3b OH 258 NNEt Q1a a bond H a bond NH S a bond Q3c OH 259 N NEt Q1a a bond H a bondNH O NH Q3a OH 260 N NEt Q1a a bond H a bond NH O NH Q3b OH 261 N NEtQ1a a bond H a bond NH O NH Q3c OH 262 N NEt Q1a a bond H a bond NH O abond Q3a OH 263 N NEt Q1a a bond H a bond NH O a bond Q3b OH 264 N NEtQ1a a bond H a bond NH O a bond Q3c OH 265 N NEt Q1b a bond Me a bond NHS NH Q3a OH 266 N NEt Q1b a bond Me a bond NH S NH Q3b OH 267 N NEt Q1ba bond Me a bond NH S NH Q3c OH 268 N NEt Q1b a bond Me a bond NH S abond Q3a OH 269 N NEt Q1b a bond Me a bond NH S a bond Q3b OH 270 N NEtQ1b a bond Me a bond NH S a bond Q3c OH 271 N NEt Q1b a bond Me a bondNH O NH Q3a OH 272 N NEt Q1b a bond Me a bond NH O NH Q3b OH 273 N NEtQ1b a bond Me a bond NH O NH Q3c OH 274 N NEt Q1b a bond Me a bond NH Oa bond Q3a OH 275 N NEt Q1b a bond Me a bond NH O a bond Q3b OH 276 NNEt Q1b a bond Me a bond NH O a bond Q3c OH 277 N NEt Q1b a bond H abond NH S NH Q3a OH 278 N NEt Q1b a bond H a bond NH S NH Q3b OH 279 NNEt Q1b a bond H a bond NH S NH Q3c OH 280 N NEt Q1b a bond H a bond NHS a bond Q3a OH 281 N NEt Q1b a bond H a bond NH S a bond Q3b OH 282 NNEt Q1b a bond H a bond NH S a bond Q3c OH 283 N NEt Q1b a bond H a bondNH O NH Q3a OH 284 N NEt Q1b a bond H a bond NH O NH Q3b OH 285 N NEtQ1b a bond H a bond NH O NH Q3c OH 286 N NEt Q1b a bond H a bond NH O abond Q3a OH 287 N NEt Q1b a bond H a bond NH O a bond Q3b OH 288 N NEtQ1b a bond H a bond NH O a bond Q3c OH 289 N NEt Q1c a bond Me a bond NHS NH Q3a OH 290 N NEt Q1c a bond Me a bond NH S NH Q3b OH 291 N NEt Q1ca bond Me a bond NH S NH Q3c OH 292 N NEt Q1c a bond Me a bond NH S abond Q3a OH 293 N NEt Q1c a bond Me a bond NH S a bond Q3b OH 294 N NEtQ1c a bond Me a bond NH S a bond Q3c OH 295 N NEt Q1c a bond Me a bondNH O NH Q3a OH 296 N NEt Q1c a bond Me a bond NH O NH Q3b OH 297 N NEtQ1c a bond Me a bond NH O NH Q3c OH 298 N NEt Q1c a bond Me a bond NH Oa bond Q3a OH 299 N NEt Q1c a bond Me a bond NH O a bond Q3b OH 300 NNEt Q1c a bond Me a bond NH O a bond Q3c OH 301 N NEt Q1c a bond H abond NH S NH Q3a OH 302 N NEt Q1c a bond H a bond NH S NH Q3b OH 303 NNEt Q1c a bond H a bond NH S NH Q3c OH 304 N NEt Q1c a bond H a bond NHS a bond Q3a OH 305 N NEt Q1c a bond H a bond NH S a bond Q3b OH 306 NNEt Q1c a bond H a bond NH S a bond Q3c OH 307 N NEt Q1c a bond H a bondNH O NH Q3a OH 308 N NEt Q1c a bond H a bond NH O NH Q3b OH 309 N NEtQ1c a bond H a bond NH O NH Q3c OH 310 N NEt Q1c a bond H a bond NH O abond Q3a OH 311 N NEt Q1c a bond H a bond NH O a bond Q3b OH 312 N NEtQ1c a bond H a bond NH O a bond Q3c OH 313 N NEt Q1d a bond Me a bond NHS NH Q3a OH 314 N NEt Q1d a bond Me a bond NH S NH Q3b OH 315 N NEt Q1da bond Me a bond NH S NH Q3c OH 316 N NEt Q1d a bond Me a bond NH S abond Q3a OH 317 N NEt Q1d a bond Me a bond NH S a bond Q3b OH 318 N NEtQ1d a bond Me a bond NH S a bond Q3c OH 319 N NEt Q1d a bond Me a bondNH O NH Q3a OH 320 N NEt Q1d a bond Me a bond NH O NH Q3b OH 321 N NEtQ1d a bond Me a bond NH O NH Q3c OH 322 N NEt Q1d a bond Me a bond NH Oa bond Q3a OH 323 N NEt Q1d a bond Me a bond NH O a bond Q3b OH 324 NNEt Q1d a bond Me a bond NH O a bond Q3c OH 325 N NEt Q1d a bond H abond NH S NH Q3a OH 326 N NEt Q1d a bond H a bond NH S NH Q3b OH 327 NNEt Q1d a bond H a bond NH S NH Q3c OH 328 N NEt Q1d a bond H a bond NHS a bond Q3a OH 329 N NEt Q1d a bond H a bond NH S a bond Q3b OH 330 NNEt Q1d a bond H a bond NH S a bond Q3c OH 331 N NEt Q1d a bond H a bondNH O NH Q3a OH 332 N NEt Q1d a bond H a bond NH O NH Q3b OH 333 N NEtQ1d a bond H a bond NH O NH Q3c OH 334 N NEt Q1d a bond H a bond NH O abond Q3a OH 335 N NEt Q1d a bond H a bond NH O a bond Q3b OH 336 N NEtQ1d a bond H a bond NH O a bond Q3c OH 337 N NEt Q1e a bond Me a bond NHS NH Q3a OH 338 N NEt Q1e a bond Me a bond NH S NH Q3b OH 339 N NEt Q1ea bond Me a bond NH S NH Q3c OH 340 N NEt Q1e a bond Me a bond NH S abond Q3a OH 341 N NEt Q1e a bond Me a bond NH S a bond Q3b OH 342 N NEtQ1e a bond Me a bond NH S a bond Q3c OH 343 N NEt Q1e a bond Me a bondNH O NH Q3a OH 344 N NEt Q1e a bond Me a bond NH O NH Q3b OH 345 N NEtQ1e a bond Me a bond NH O NH Q3c OH 346 N NEt Q1e a bond Me a bond NH Oa bond Q3a OH 347 N NEt Q1e a bond Me a bond NH O a bond Q3b OH 348 NNEt Q1e a bond Me a bond NH O a bond Q3c OH 349 N NEt Q1e a bond H abond NH S NH Q3a OH 350 N NEt Q1e a bond H a bond NH S NH Q3b OH 351 NNEt Q1e a bond H a bond NH S NH Q3c OH 352 N NEt Q1e a bond H a bond NHS a bond Q3a OH 353 N NEt Q1e a bond H a bond NH S a bond Q3b OH 354 NNEt Q1e a bond H a bond NH S a bond Q3c OH 355 N NEt Q1e a bond H a bondNH O NH Q3a OH 356 N NEt Q1e a bond H a bond NH O NH Q3b OH 357 N NEtQ1e a bond H a bond NH O NH Q3c OH 358 N NEt Q1e a bond H a bond NH O abond Q3a OH 359 N NEt Q1e a bond H a bond NH O a bond Q3b OH 360 N NEtQ1e a bond H a bond NH O a bond Q3c OH 361 N NEt Q1f a bond Me a bond NHS NH Q3a OH 362 N NEt Q1f a bond Me a bond NH S NH Q3b OH 363 N NEt Q1fa bond Me a bond NH S NH Q3c OH 364 N NEt Q1f a bond Me a bond NH S abond Q3a OH 365 N NEt Q1f a bond Me a bond NH S a bond Q3b OH 366 N NEtQ1f a bond Me a bond NH S a bond Q3c OH 367 N NEt Q1f a bond Me a bondNH O NH Q3a OH 368 N NEt Q1f a bond Me a bond NH O NH Q3b OH 369 N NEtQ1f a bond Me a bond NH O NH Q3c OH 370 N NEt Q1f a bond Me a bond NH Oa bond Q3a OH 371 N NEt Q1f a bond Me a bond NH O a bond Q3b OH 372 NNEt Q1f a bond Me a bond NH O a bond Q3c OH 373 N NEt Q1f a bond H abond NH S NH Q3a OH 374 N NEt Q1f a bond H a bond NH S NH Q3b OH 375 NNEt Q1f a bond H a bond NH S NH Q3c OH 376 N NEt Q1f a bond H a bond NHS a bond Q3a OH 377 N NEt Q1f a bond H a bond NH S a bond Q3b OH 378 NNEt Q1f a bond H a bond NH S a bond Q3c OH 379 N NEt Q1f a bond H a bondNH O NH Q3a OH 380 N NEt Q1f a bond H a bond NH O NH Q3b OH 381 N NEtQ1f a bond H a bond NH O NH Q3c OH 382 N NEt Q1f a bond H a bond NH O abond Q3a OH 383 N NEt Q1f a bond H a bond NH O a bond Q3b OH 384 N NEtQ1f a bond H a bond NH O a bond Q3c OH 385 N NEt Q1g a bond Me a bond NHS NH Q3a OH 386 N NEt Q1g a bond Me a bond NH S NH Q3b OH 387 N NEt Q1ga bond Me a bond NH S NH Q3c OH 388 N NEt Q1g a bond Me a bond NH S abond Q3a OH 389 N NEt Q1g a bond Me a bond NH S a bond Q3b OH 390 N NEtQ1g a bond Me a bond NH S a bond Q3c OH 391 N NEt Q1g a bond Me a bondNH O NH Q3a OH 392 N NEt Q1g a bond Me a bond NH O NH Q3b OH 393 N NEtQ1g a bond Me a bond NH O NH Q3c OH 394 N NEt Q1g a bond Me a bond NH Oa bond Q3a OH 395 N NEt Q1g a bond Me a bond NH O a bond Q3b OH 396 NNEt Q1g a bond Me a bond NH O a bond Q3c OH 397 N NEt Q1g a bond H abond NH S NH Q3a OH 398 N NEt Q1g a bond H a bond NH S NH Q3b OH 399 NNEt Q1g a bond H a bond NH S NH Q3c OH 400 N NEt Q1g a bond H a bond NHS a bond Q3a OH 401 N NEt Q1g a bond H a bond NH S a bond Q3b OH 402 NNEt Q1g a bond H a bond NH S a bond Q3c OH 403 N NEt Q1g a bond H a bondNH O NH Q3a OH 404 N NEt Q1g a bond H a bond NH O NH Q3b OH 405 N NEtQ1g a bond H a bond NH O NH Q3c OH 406 N NEt Q1g a bond H a bond NH O abond Q3a OH 407 N NEt Q1g a bond H a bond NH O a bond Q3b OH 408 N NEtQ1g a bond H a bond NH O a bond Q3c OH 409 N NEt Q1h a bond Me a bond NHS NH Q3a OH 410 N NEt Q1h a bond Me a bond NH S NH Q3b OH 411 N NEt Q1ha bond Me a bond NH S NH Q3c OH 412 N NEt Q1h a bond Me a bond NH S abond Q3a OH 413 N NEt Q1h a bond Me a bond NH S a bond Q3b OH 414 N NEtQ1h a bond Me a bond NH S a bond Q3c OH 415 N NEt Q1h a bond Me a bondNH O NH Q3a OH 416 N NEt Q1h a bond Me a bond NH O NH Q3b OH 417 N NEtQ1h a bond Me a bond NH O NH Q3c OH 418 N NEt Q1h a bond Me a bond NH Oa bond Q3a OH 419 N NEt Q1h a bond Me a bond NH O a bond Q3b OH 420 NNEt Q1h a bond Me a bond NH O a bond Q3c OH 421 N NEt Q1h a bond H abond NH S NH Q3a OH 422 N NEt Q1h a bond H a bond NH S NH Q3b OH 423 NNEt Q1h a bond H a bond NH S NH Q3c OH 424 N NEt Q1h a bond H a bond NHS a bond Q3a OH 425 N NEt Q1h a bond H a bond NH S a bond Q3b OH 426 NNEt Q1h a bond H a bond NH S a bond Q3c OH 427 N NEt Q1h a bond H a bondNH O NH Q3a OH 428 N NEt Q1h a bond H a bond NH O NH Q3b OH 429 N NEtQ1h a bond H a bond NH O NH Q3c OH 430 N NEt Q1h a bond H a bond NH O abond Q3a OH 431 N NEt Q1h a bond H a bond NH O a bond Q3b OH 432 N NEtQ1h a bond H a bond NH O a bond Q3c OH 433 N NEt Q1i a bond Me a bond NHS NH Q3a OH 434 N NEt Q1i a bond Me a bond NH S NH Q3b OH 435 N NEt Q1ia bond Me a bond NH S NH Q3c OH 436 N NEt Q1i a bond Me a bond NH S abond Q3a OH 437 N NEt Q1i a bond Me a bond NH S a bond Q3b OH 438 N NEtQ1i a bond Me a bond NH S a bond Q3c OH 439 N NEt Q1i a bond Me a bondNH O NH Q3a OH 440 N NEt Q1i a bond Me a bond NH O NH Q3b OH 441 N NEtQ1i a bond Me a bond NH O NH Q3c OH 442 N NEt Q1i a bond Me a bond NH Oa bond Q3a OH 443 N NEt Q1i a bond Me a bond NH O a bond Q3b OH 444 NNEt Q1i a bond Me a bond NH O a bond Q3c OH 445 N NEt Q1i a bond H abond NH S NH Q3a OH 446 N NEt Q1i a bond H a bond NH S NH Q3b OH 447 NNEt Q1i a bond H a bond NH S NH Q3c OH 448 N NEt Q1i a bond H a bond NHS a bond Q3a OH 449 N NEt Q1i a bond H a bond NH S a bond Q3b OH 450 NNEt Q1i a bond H a bond NH S a bond Q3c OH 451 N NEt Q1i a bond H a bondNH O NH Q3a OH 452 N NEt Q1i a bond H a bond NH O NH Q3b OH 453 N NEtQ1i a bond H a bond NH O NH Q3c OH 454 N NEt Q1i a bond H a bond NH O abond Q3a OH 455 N NEt Q1i a bond H a bond NH O a bond Q3b OH 456 N NEtQ1i a bond H a bond NH O a bond Q3c OH 457 N NEt Q1j a bond Me a bond NHS NH Q3a OH 458 N NEt Q1j a bond Me a bond NH S NH Q3b OH 459 N NEt Q1ja bond Me a bond NH S NH Q3c OH 460 N NEt Q1j a bond Me a bond NH S abond Q3a OH 461 N NEt Q1j a bond Me a bond NH S a bond Q3b OH 462 N NEtQ1j a bond Me a bond NH S a bond Q3c OH 463 N NEt Q1j a bond Me a bondNH O NH Q3a OH 464 N NEt Q1j a bond Me a bond NH O NH Q3b OH 465 N NEtQ1j a bond Me a bond NH O NH Q3c OH 466 N NEt Q1j a bond Me a bond NH Oa bond Q3a OH 467 N NEt Q1j a bond Me a bond NH O a bond Q3b OH 468 NNEt Q1j a bond Me a bond NH O a bond Q3c OH 469 N NEt Q1j a bond H abond NH S NH Q3a OH 470 N NEt Q1j a bond H a bond NH S NH Q3b OH 471 NNEt Q1j a bond H a bond NH S NH Q3c OH 472 N NEt Q1j a bond H a bond NHS a bond Q3a OH 473 N NEt Q1j a bond H a bond NH S a bond Q3b OH 474 NNEt Q1j a bond H a bond NH S a bond Q3c OH 475 N NEt Q1j a bond H a bondNH O NH Q3a OH 476 N NEt Q1j a bond H a bond NH O NH Q3b OH 477 N NEtQ1j a bond H a bond NH O NH Q3c OH 478 N NEt Q1j a bond H a bond NH O abond Q3a OH 479 N NEt Q1j a bond H a bond NH O a bond Q3b OH 480 N NEtQ1j a bond H a bond NH O a bond Q3c OH 481 N S Q1a a bond Me a bond NH SNH Q3a OH 482 N S Q1a a bond Me a bond NH S NH Q3b OH 483 N S Q1a a bondMe a bond NH S NH Q3c OH 484 N S Q1a a bond Me a bond NH S a bond Q3a OH485 N S Q1a a bond Me a bond NH S a bond Q3b OH 486 N S Q1a a bond Me abond NH S a bond Q3c OH 487 N S Q1a a bond Me a bond NH O NH Q3a OH 488N S Q1a a bond Me a bond NH O NH Q3b OH 489 N S Q1a a bond Me a bond NHO NH Q3c OH 490 N S Q1a a bond Me a bond NH O a bond Q3a OH 491 N S Q1aa bond Me a bond NH O a bond Q3b OH 492 N S Q1a a bond Me a bond NH O abond Q3c OH 493 N S Q1a a bond H a bond NH S NH Q3a OH 494 N S Q1a abond H a bond NH S NH Q3b OH 495 N S Q1a a bond H a bond NH S NH Q3c OH496 N S Q1a a bond H a bond NH S a bond Q3a OH 497 N S Q1a a bond H abond NH S a bond Q3b OH 498 N S Q1a a bond H a bond NH S a bond Q3c OH499 N S Q1a a bond H a bond NH O NH Q3a OH 500 N S Q1a a bond H a bondNH O NH Q3b OH 501 N S Q1a a bond H a bond NH O NH Q3c OH 502 N S Q1a abond H a bond NH O a bond Q3a OH 503 N S Q1a a bond H a bond NH O a bondQ3b OH 504 N S Q1a a bond H a bond NH O a bond Q3c OH 505 N S Q1b a bondMe a bond NH S NH Q3a OH 506 N S Q1b a bond Me a bond NH S NH Q3b OH 507N S Q1b a bond Me a bond NH S NH Q3c OH 508 N S Q1b a bond Me a bond NHS a bond Q3a OH 509 N S Q1b a bond Me a bond NH S a bond Q3b OH 510 N SQ1b a bond Me a bond NH S a bond Q3c OH 511 N S Q1b a bond Me a bond NHO NH Q3a OH 512 N S Q1b a bond Me a bond NH O NH Q3b OH 513 N S Q1b abond Me a bond NH O NH Q3c OH 514 N S Q1b a bond Me a bond NH O a bondQ3a OH 515 N S Q1b a bond Me a bond NH O a bond Q3b OH 516 N S Q1b abond Me a bond NH O a bond Q3c OH 517 N S Q1b a bond H a bond NH S NHQ3a OH 518 N S Q1b a bond H a bond NH S NH Q3b OH 519 N S Q1b a bond H abond NH S NH Q3c OH 520 N S Q1b a bond H a bond NH S a bond Q3a OH 521 NS Q1b a bond H a bond NH S a bond Q3b OH 522 N S Q1b a bond H a bond NHS a bond Q3c OH 523 N S Q1b a bond H a bond NH O NH Q3a OH 524 N S Q1b abond H a bond NH O NH Q3b OH 525 N S Q1b a bond H a bond NH O NH Q3c OH526 N S Q1b a bond H a bond NH O a bond Q3a OH 527 N S Q1b a bond H abond NH O a bond Q3b OH 528 N S Q1b a bond H a bond NH O a bond Q3c OH529 N S Q1c a bond Me a bond NH S NH Q3a OH 530 N S Q1c a bond Me a bondNH S NH Q3b OH 531 N S Q1c a bond Me a bond NH S NH Q3c OH 532 N S Q1c abond Me a bond NH S a bond Q3a OH 533 N S Q1c a bond Me a bond NH S abond Q3b OH 534 N S Q1c a bond Me a bond NH S a bond Q3c OH 535 N S Q1ca bond Me a bond NH O NH Q3a OH 536 N S Q1c a bond Me a bond NH O NH Q3bOH 537 N S Q1c a bond Me a bond NH O NH Q3c OH 538 N S Q1c a bond Me abond NH O a bond Q3a OH 539 N S Q1c a bond Me a bond NH O a bond Q3b OH540 N S Q1c a bond Me a bond NH O a bond Q3c OH 541 N S Q1c a bond H abond NH S NH Q3a OH 542 N S Q1c a bond H a bond NH S NH Q3b OH 543 N SQ1c a bond H a bond NH S NH Q3c OH 544 N S Q1c a bond H a bond NH S abond Q3a OH 545 N S Q1c a bond H a bond NH S a bond Q3b OH 546 N S Q1c abond H a bond NH S a bond Q3c OH 547 N S Q1c a bond H a bond NH O NH Q3aOH 548 N S Q1c a bond H a bond NH O NH Q3b OH 549 N S Q1c a bond H abond NH O NH Q3c OH 550 N S Q1c a bond H a bond NH O a bond Q3a OH 551 NS Q1c a bond H a bond NH O a bond Q3b OH 552 N S Q1c a bond H a bond NHO a bond Q3c OH 553 N S Q1d a bond Me a bond NH S NH Q3a OH 554 N S Q1da bond Me a bond NH S NH Q3b OH 555 N S Q1d a bond Me a bond NH S NH Q3cOH 556 N S Q1d a bond Me a bond NH S a bond Q3a OH 557 N S Q1d a bond Mea bond NH S a bond Q3b OH 558 N S Q1d a bond Me a bond NH S a bond Q3cOH 559 N S Q1d a bond Me a bond NH O NH Q3a OH 560 N S Q1d a bond Me abond NH O NH Q3b OH 561 N S Q1d a bond Me a bond NH O NH Q3c OH 562 N SQ1d a bond Me a bond NH O a bond Q3a OH 563 N S Q1d a bond Me a bond NHO a bond Q3b OH 564 N S Q1d a bond Me a bond NH O a bond Q3c OH 565 N SQ1d a bond H a bond NH S NH Q3a OH 566 N S Q1d a bond H a bond NH S NHQ3b OH 567 N S Q1d a bond H a bond NH S NH Q3c OH 568 N S Q1d a bond H abond NH S a bond Q3a OH 569 N S Q1d a bond H a bond NH S a bond Q3b OH570 N S Q1d a bond H a bond NH S a bond Q3c OH 571 N S Q1d a bond H abond NH O NH Q3a OH 572 N S Q1d a bond H a bond NH O NH Q3b OH 573 N SQ1d a bond H a bond NH O NH Q3c OH 574 N S Q1d a bond H a bond NH O abond Q3a OH 575 N S Q1d a bond H a bond NH O a bond Q3b OH 576 N S Q1d abond H a bond NH O a bond Q3c OH 577 N S Q1e a bond Me a bond NH S NHQ3a OH 578 N S Q1e a bond Me a bond NH S NH Q3b OH 579 N S Q1e a bond Mea bond NH S NH Q3c OH 580 N S Q1e a bond Me a bond NH S a bond Q3a OH581 N S Q1e a bond Me a bond NH S a bond Q3b OH 582 N S Q1e a bond Me abond NH S a bond Q3c OH 583 N S Q1e a bond Me a bond NH O NH Q3a OH 584N S Q1e a bond Me a bond NH O NH Q3b OH 585 N S Q1e a bond Me a bond NHO NH Q3c OH 586 N S Q1e a bond Me a bond NH O a bond Q3a OH 587 N S Q1ea bond Me a bond NH O a bond Q3b OH 588 N S Q1e a bond Me a bond NH O abond Q3c OH 589 N S Q1e a bond H a bond NH S NH Q3a OH 590 N S Q1e abond H a bond NH S NH Q3b OH 591 N S Q1e a bond H a bond NH S NH Q3c OH592 N S Q1e a bond H a bond NH S a bond Q3a OH 593 N S Q1e a bond H abond NH S a bond Q3b OH 594 N S Q1e a bond H a bond NH S a bond Q3c OH595 N S Q1e a bond H a bond NH O NH Q3a OH 596 N S Q1e a bond H a bondNH O NH Q3b OH 597 N S Q1e a bond H a bond NH O NH Q3c OH 598 N S Q1e abond H a bond NH O a bond Q3a OH 599 N S Q1e a bond H a bond NH O a bondQ3b OH 600 N S Q1e a bond H a bond NH O a bond Q3c OH 601 N S Q1f a bondMe a bond NH S NH Q3a OH 602 N S Q1f a bond Me a bond NH S NH Q3b OH 603N S Q1f a bond Me a bond NH S NH Q3c OH 604 N S Q1f a bond Me a bond NHS a bond Q3a OH 605 N S Q1f a bond Me a bond NH S a bond Q3b OH 606 N SQ1f a bond Me a bond NH S a bond Q3c OH 607 N S Q1f a bond Me a bond NHO NH Q3a OH 608 N S Q1f a bond Me a bond NH O NH Q3b OH 609 N S Q1f abond Me a bond NH O NH Q3c OH 610 N S Q1f a bond Me a bond NH O a bondQ3a OH 611 N S Q1f a bond Me a bond NH O a bond Q3b OH 612 N S Q1f abond Me a bond NH O a bond Q3c OH 613 N S Q1f a bond H a bond NH S NHQ3a OH 614 N S Q1f a bond H a bond NH S NH Q3b OH 615 N S Q1f a bond H abond NH S NH Q3c OH 616 N S Q1f a bond H a bond NH S a bond Q3a OH 617 NS Q1f a bond H a bond NH S a bond Q3b OH 618 N S Q1f a bond H a bond NHS a bond Q3c OH 619 N S Q1f a bond H a bond NH O NH Q3a OH 620 N S Q1f abond H a bond NH O NH Q3b OH 621 N S Q1f a bond H a bond NH O NH Q3c OH622 N S Q1f a bond H a bond NH O a bond Q3a OH 623 N S Q1f a bond H abond NH O a bond Q3b OH 624 N S Q1f a bond H a bond NH O a bond Q3c OH625 N S Q1g a bond Me a bond NH S NH Q3a OH 626 N S Q1g a bond Me a bondNH S NH Q3b OH 627 N S Q1g a bond Me a bond NH S NH Q3c OH 628 N S Q1g abond Me a bond NH S a bond Q3a OH 629 N S Q1g a bond Me a bond NH S abond Q3b OH 630 N S Q1g a bond Me a bond NH S a bond Q3c OH 631 N S Q1ga bond Me a bond NH O NH Q3a OH 632 N S Q1g a bond Me a bond NH O NH Q3bOH 633 N S Q1g a bond Me a bond NH O NH Q3c OH 634 N S Q1g a bond Me abond NH O a bond Q3a OH 635 N S Q1g a bond Me a bond NH O a bond Q3b OH636 N S Q1g a bond Me a bond NH O a bond Q3c OH 637 N S Q1g a bond H abond NH S NH Q3a OH 638 N S Q1g a bond H a bond NH S NH Q3b OH 639 N SQ1g a bond H a bond NH S NH Q3c OH 640 N S Q1g a bond H a bond NH S abond Q3a OH 641 N S Q1g a bond H a bond NH S a bond Q3b OH 642 N S Q1g abond H a bond NH S a bond Q3c OH 643 N S Q1g a bond H a bond NH O NH Q3aOH 644 N S Q1g a bond H a bond NH O NH Q3b OH 645 N S Q1g a bond H abond NH O NH Q3c OH 646 N S Q1g a bond H a bond NH O a bond Q3a OH 647 NS Q1g a bond H a bond NH O a bond Q3b OH 648 N S Q1g a bond H a bond NHO a bond Q3c OH 649 N S Q1h a bond Me a bond NH S NH Q3a OH 650 N S Q1ha bond Me a bond NH S NH Q3b OH 651 N S Q1h a bond Me a bond NH S NH Q3cOH 652 N S Q1h a bond Me a bond NH S a bond Q3a OH 653 N S Q1h a bond Mea bond NH S a bond Q3b OH 654 N S Q1h a bond Me a bond NH S a bond Q3cOH 655 N S Q1h a bond Me a bond NH O NH Q3a OH 656 N S Q1h a bond Me abond NH O NH Q3b OH 657 N S Q1h a bond Me a bond NH O NH Q3c OH 658 N SQ1h a bond Me a bond NH O a bond Q3a OH 659 N S Q1h a bond Me a bond NHO a bond Q3b OH 660 N S Q1h a bond Me a bond NH O a bond Q3c OH 661 N SQ1h a bond H a bond NH S NH Q3a OH 662 N S Q1h a bond H a bond NH S NHQ3b OH 663 N S Q1h a bond H a bond NH S NH Q3c OH 664 N S Q1h a bond H abond NH S a bond Q3a OH 665 N S Q1h a bond H a bond NH S a bond Q3b OH666 N S Q1h a bond H a bond NH S a bond Q3c OH 667 N S Q1h a bond H abond NH O NH Q3a OH 668 N S Q1h a bond H a bond NH O NH Q3b OH 669 N SQ1h a bond H a bond NH O NH Q3c OH 670 N S Q1h a bond H a bond NH O abond Q3a OH 671 N S Q1h a bond H a bond NH O a bond Q3b OH 672 N S Q1h abond H a bond NH O a bond Q3c OH 673 N S Q1i a bond Me a bond NH S NHQ3a OH 674 N S Q1i a bond Me a bond NH S NH Q3b OH 675 N S Q1i a bond Mea bond NH S NH Q3c OH 676 N S Q1i a bond Me a bond NH S a bond Q3a OH677 N S Q1i a bond Me a bond NH S a bond Q3b OH 678 N S Q1i a bond Me abond NH S a bond Q3c OH 679 N S Q1i a bond Me a bond NH O NH Q3a OH 680N S Q1i a bond Me a bond NH O NH Q3b OH 681 N S Q1i a bond Me a bond NHO NH Q3c OH 682 N S Q1i a bond Me a bond NH O a bond Q3a OH 683 N S Q1ia bond Me a bond NH O a bond Q3b OH 684 N S Q1i a bond Me a bond NH O abond Q3c OH 685 N S Q1i a bond H a bond NH S NH Q3a OH 686 N S Q1i abond H a bond NH S NH Q3b OH 687 N S Q1i a bond H a bond NH S NH Q3c OH688 N S Q1i a bond H a bond NH S a bond Q3a OH 689 N S Q1i a bond H abond NH S a bond Q3b OH 690 N S Q1i a bond H a bond NH S a bond Q3c OH691 N S Q1i a bond H a bond NH O NH Q3a OH 692 N S Q1i a bond H a bondNH O NH Q3b OH 693 N S Q1i a bond H a bond NH O NH Q3c OH 694 N S Q1i abond H a bond NH O a bond Q3a OH 695 N S Q1i a bond H a bond NH O a bondQ3b OH 696 N S Q1i a bond H a bond NH O a bond Q3c OH 697 N S Q1j a bondMe a bond NH S NH Q3a OH 698 N S Q1j a bond Me a bond NH S NH Q3b OH 699N S Q1j a bond Me a bond NH S NH Q3c OH 700 N S Q1j a bond Me a bond NHS a bond Q3a OH 701 N S Q1j a bond Me a bond NH S a bond Q3b OH 702 N SQ1j a bond Me a bond NH S a bond Q3c OH 703 N S Q1j a bond Me a bond NHO NH Q3a OH 704 N S Q1j a bond Me a bond NH O NH Q3b OH 705 N S Q1j abond Me a bond NH O NH Q3c OH 706 N S Q1j a bond Me a bond NH O a bondQ3a OH 707 N S Q1j a bond Me a bond NH O a bond Q3b OH 708 N S Q1j abond Me a bond NH O a bond Q3c OH 709 N S Q1j a bond H a bond NH S NHQ3a OH 710 N S Q1j a bond H a bond NH S NH Q3b OH 711 N S Q1j a bond H abond NH S NH Q3c OH 712 N S Q1j a bond H a bond NH S a bond Q3a OH 713 NS Q1j a bond H a bond NH S a bond Q3b OH 714 N S Q1j a bond H a bond NHS a bond Q3c OH 715 N S Q1j a bond H a bond NH O NH Q3a OH 716 N S Q1j abond H a bond NH O NH Q3b OH 717 N S Q1j a bond H a bond NH O NH Q3c OH718 N S Q1j a bond H a bond NH O a bond Q3a OH 719 N S Q1j a bond H abond NH O a bond Q3b OH 720 N S Q1j a bond H a bond NH O a bond Q3c OH721 N O Q1a a bond Me a bond NH S NH Q3a OH 722 N O Q1a a bond Me a bondNH S NH Q3b OH 723 N O Q1a a bond Me a bond NH S NH Q3c OH 724 N O Q1a abond Me a bond NH S a bond Q3a OH 725 N O Q1a a bond Me a bond NH S abond Q3b OH 726 N O Q1a a bond Me a bond NH S a bond Q3c OH 727 N O Q1aa bond Me a bond NH O NH Q3a OH 728 N O Q1a a bond Me a bond NH O NH Q3bOH 729 N O Q1a a bond Me a bond NH O NH Q3c OH 730 N O Q1a a bond Me abond NH O a bond Q3a OH 731 N O Q1a a bond Me a bond NH O a bond Q3b OH732 N O Q1a a bond Me a bond NH O a bond Q3c OH 733 N O Q1a a bond H abond NH S NH Q3a OH 734 N O Q1a a bond H a bond NH S NH Q3b OH 735 N OQ1a a bond H a bond NH S NH Q3c OH 736 N O Q1a a bond H a bond NH S abond Q3a OH 737 N O Q1a a bond H a bond NH S a bond Q3b OH 738 N O Q1a abond H a bond NH S a bond Q3c OH 739 N O Q1a a bond H a bond NH O NH Q3aOH 740 N O Q1a a bond H a bond NH O NH Q3b OH 741 N O Q1a a bond H abond NH O NH Q3c OH 742 N O Q1a a bond H a bond NH O a bond Q3a OH 743 NO Q1a a bond H a bond NH O a bond Q3b OH 744 N O Q1a a bond H a bond NHO a bond Q3c OH 745 N O Q1b a bond Me a bond NH S NH Q3a OH 746 N O Q1ba bond Me a bond NH S NH Q3b OH 747 N O Q1b a bond Me a bond NH S NH Q3cOH 748 N O Q1b a bond Me a bond NH S a bond Q3a OH 749 N O Q1b a bond Mea bond NH S a bond Q3b OH 750 N O Q1b a bond Me a bond NH S a bond Q3cOH 751 N O Q1b a bond Me a bond NH O NH Q3a OH 752 N O Q1b a bond Me abond NH O NH Q3b OH 753 N O Q1b a bond Me a bond NH O NH Q3c OH 754 N OQ1b a bond Me a bond NH O a bond Q3a OH 755 N O Q1b a bond Me a bond NHO a bond Q3b OH 756 N O Q1b a bond Me a bond NH O a bond Q3c OH 757 N OQ1b a bond H a bond NH S NH Q3a OH 758 N O Q1b a bond H a bond NH S NHQ3b OH 759 N O Q1b a bond H a bond NH S NH Q3c OH 760 N O Q1b a bond H abond NH S a bond Q3a OH 761 N O Q1b a bond H a bond NH S a bond Q3b OH762 N O Q1b a bond H a bond NH S a bond Q3c OH 763 N O Q1b a bond H abond NH O NH Q3a OH 764 N O Q1b a bond H a bond NH O NH Q3b OH 765 N OQ1b a bond H a bond NH O NH Q3c OH 766 N O Q1b a bond H a bond NH O abond Q3a OH 767 N O Q1b a bond H a bond NH O a bond Q3b OH 768 N O Q1b abond H a bond NH O a bond Q3c OH 769 N O Q1c a bond Me a bond NH S NHQ3a OH 770 N O Q1c a bond Me a bond NH S NH Q3b OH 771 N O Q1c a bond Mea bond NH S NH Q3c OH 772 N O Q1c a bond Me a bond NH S a bond Q3a OH773 N O Q1c a bond Me a bond NH S a bond Q3b OH 774 N O Q1c a bond Me abond NH S a bond Q3c OH 775 N O Q1c a bond Me a bond NH O NH Q3a OH 776N O Q1c a bond Me a bond NH O NH Q3b OH 777 N O Q1c a bond Me a bond NHO NH Q3c OH 778 N O Q1c a bond Me a bond NH O a bond Q3a OH 779 N O Q1ca bond Me a bond NH O a bond Q3b OH 780 N O Q1c a bond Me a bond NH O abond Q3c OH 781 N O Q1c a bond H a bond NH S NH Q3a OH 782 N O Q1c abond H a bond NH S NH Q3b OH 783 N O Q1c a bond H a bond NH S NH Q3c OH784 N O Q1c a bond H a bond NH S a bond Q3a OH 785 N O Q1c a bond H abond NH S a bond Q3b OH 786 N O Q1c a bond H a bond NH S a bond Q3c OH787 N O Q1c a bond H a bond NH O NH Q3a OH 788 N O Q1c a bond H a bondNH O NH Q3b OH 789 N O Q1c a bond H a bond NH O NH Q3c OH 790 N O Q1c abond H a bond NH O a bond Q3a OH 791 N O Q1c a bond H a bond NH O a bondQ3b OH 792 N O Q1c a bond H a bond NH O a bond Q3c OH 793 N O Q1d a bondMe a bond NH S NH Q3a OH 794 N O Q1d a bond Me a bond NH S NH Q3b OH 795N O Q1d a bond Me a bond NH S NH Q3c OH 796 N O Q1d a bond Me a bond NHS a bond Q3a OH 797 N O Q1d a bond Me a bond NH S a bond Q3b OH 798 N OQ1d a bond Me a bond NH S a bond Q3c OH 799 N O Q1d a bond Me a bond NHO NH Q3a OH 800 N O Q1d a bond Me a bond NH O NH Q3b OH 801 N O Q1d abond Me a bond NH O NH Q3c OH 802 N O Q1d a bond Me a bond NH O a bondQ3a OH 803 N O Q1d a bond Me a bond NH O a bond Q3b OH 804 N O Q1d abond Me a bond NH O a bond Q3c OH 805 N O Q1d a bond H a bond NH S NHQ3a OH 806 N O Q1d a bond H a bond NH S NH Q3b OH 807 N O Q1d a bond H abond NH S NH Q3c OH 808 N O Q1d a bond H a bond NH S a bond Q3a OH 809 NO Q1d a bond H a bond NH S a bond Q3b OH 810 N O Q1d a bond H a bond NHS a bond Q3c OH 811 N O Q1d a bond H a bond NH O NH Q3a OH 812 N O Q1d abond H a bond NH O NH Q3b OH 813 N O Q1d a bond H a bond NH O NH Q3c OH814 N O Q1d a bond H a bond NH O a bond Q3a OH 815 N O Q1d a bond H abond NH O a bond Q3b OH 816 N O Q1d a bond H a bond NH O a bond Q3c OH817 N O Q1e a bond Me a bond NH S NH Q3a OH 818 N O Q1e a bond Me a bondNH S NH Q3b OH 819 N O Q1e a bond Me a bond NH S NH Q3c OH 820 N O Q1e abond Me a bond NH S a bond Q3a OH 821 N O Q1e a bond Me a bond NH S abond Q3b OH 822 N O Q1e a bond Me a bond NH S a bond Q3c OH 823 N O Q1ea bond Me a bond NH O NH Q3a OH 824 N O Q1e a bond Me a bond NH O NH Q3bOH 825 N O Q1e a bond Me a bond NH O NH Q3c OH 826 N O Q1e a bond Me abond NH O a bond Q3a OH 827 N O Q1e a bond Me a bond NH O a bond Q3b OH828 N O Q1e a bond Me a bond NH O a bond Q3c OH 829 N O Q1e a bond H abond NH S NH Q3a OH 830 N O Q1e a bond H a bond NH S NH Q3b OH 831 N OQ1e a bond H a bond NH S NH Q3c OH 832 N O Q1e a bond H a bond NH S abond Q3a OH 833 N O Q1e a bond H a bond NH S a bond Q3b OH 834 N O Q1e abond H a bond NH S a bond Q3c OH 835 N O Q1e a bond H a bond NH O NH Q3aOH 836 N O Q1e a bond H a bond NH O NH Q3b OH 837 N O Q1e a bond H abond NH O NH Q3c OH 838 N O Q1e a bond H a bond NH O a bond Q3a OH 839 NO Q1e a bond H a bond NH O a bond Q3b OH 840 N O Q1e a bond H a bond NHO a bond Q3c OH 841 N O Q1f a bond Me a bond NH S NH Q3a OH 842 N O Q1fa bond Me a bond NH S NH Q3b OH 843 N O Q1f a bond Me a bond NH S NH Q3cOH 844 N O Q1f a bond Me a bond NH S a bond Q3a OH 845 N O Q1f a bond Mea bond NH S a bond Q3b OH 846 N O Q1f a bond Me a bond NH S a bond Q3cOH 847 N O Q1f a bond Me a bond NH O NH Q3a OH 848 N O Q1f a bond Me abond NH O NH Q3b OH 849 N O Q1f a bond Me a bond NH O NH Q3c OH 850 N OQ1f a bond Me a bond NH O a bond Q3a OH 851 N O Q1f a bond Me a bond NHO a bond Q3b OH 852 N O Q1f a bond Me a bond NH O a bond Q3c OH 853 N OQ1f a bond H a bond NH S NH Q3a OH 854 N O Q1f a bond H a bond NH S NHQ3b OH 855 N O Q1f a bond H a bond NH S NH Q3c OH 856 N O Q1f a bond H abond NH S a bond Q3a OH 857 N O Q1f a bond H a bond NH S a bond Q3b OH858 N O Q1f a bond H a bond NH S a bond Q3c OH 859 N O Q1f a bond H abond NH O NH Q3a OH 860 N O Q1f a bond H a bond NH O NH Q3b OH 861 N OQ1f a bond H a bond NH O NH Q3c OH 862 N O Q1f a bond H a bond NH O abond Q3a OH 863 N O Q1f a bond H a bond NH O a bond Q3b OH 864 N O Q1f abond H a bond NH O a bond Q3c OH 865 N O Q1g a bond Me a bond NH S NHQ3a OH 866 N O Q1g a bond Me a bond NH S NH Q3b OH 867 N O Q1g a bond Mea bond NH S NH Q3c OH 868 N O Q1g a bond Me a bond NH S a bond Q3a OH869 N O Q1g a bond Me a bond NH S a bond Q3b OH 870 N O Q1g a bond Me abond NH S a bond Q3c OH 871 N O Q1g a bond Me a bond NH O NH Q3a OH 872N O Q1g a bond Me a bond NH O NH Q3b OH 873 N O Q1g a bond Me a bond NHO NH Q3c OH 874 N O Q1g a bond Me a bond NH O a bond Q3a OH 875 N O Q1ga bond Me a bond NH O a bond Q3b OH 876 N O Q1g a bond Me a bond NH O abond Q3c OH 877 N O Q1g a bond H a bond NH S NH Q3a OH 878 N O Q1g abond H a bond NH S NH Q3b OH 879 N O Q1g a bond H a bond NH S NH Q3c OH880 N O Q1g a bond H a bond NH S a bond Q3a OH 881 N O Q1g a bond H abond NH S a bond Q3b OH 882 N O Q1g a bond H a bond NH S a bond Q3c OH883 N O Q1g a bond H a bond NH O NH Q3a OH 884 N O Q1g a bond H a bondNH O NH Q3b OH 885 N O Q1g a bond H a bond NH O NH Q3c OH 886 N O Q1g abond H a bond NH O a bond Q3a OH 887 N O Q1g a bond H a bond NH O a bondQ3b OH 888 N O Q1g a bond H a bond NH O a bond Q3c OH 889 N O Q1h a bondMe a bond NH S NH Q3a OH 890 N O Q1h a bond Me a bond NH S NH Q3b OH 891N O Q1h a bond Me a bond NH S NH Q3c OH 892 N O Q1h a bond Me a bond NHS a bond Q3a OH 893 N O Q1h a bond Me a bond NH S a bond Q3b OH 894 N OQ1h a bond Me a bond NH S a bond Q3c OH 895 N O Q1h a bond Me a bond NHO NH Q3a OH 896 N O Q1h a bond Me a bond NH O NH Q3b OH 897 N O Q1h abond Me a bond NH O NH Q3c OH 898 N O Q1h a bond Me a bond NH O a bondQ3a OH 899 N O Q1h a bond Me a bond NH O a bond Q3b OH 900 N O Q1h abond Me a bond NH O a bond Q3c OH 901 N O Q1h a bond H a bond NH S NHQ3a OH 902 N O Q1h a bond H a bond NH S NH Q3b OH 903 N O Q1h a bond H abond NH S NH Q3c OH 904 N O Q1h a bond H a bond NH S a bond Q3a OH 905 NO Q1h a bond H a bond NH S a bond Q3b OH 906 N O Q1h a bond H a bond NHS a bond Q3c OH 907 N O Q1h a bond H a bond NH O NH Q3a OH 908 N O Q1h abond H a bond NH O NH Q3b OH 909 N O Q1h a bond H a bond NH O NH Q3c OH910 N O Q1h a bond H a bond NH O a bond Q3a OH 911 N O Q1h a bond H abond NH O a bond Q3b OH 912 N O Q1h a bond H a bond NH O a bond Q3c OH913 N O Q1i a bond Me a bond NH S NH Q3a OH 914 N O Q1i a bond Me a bondNH S NH Q3b OH 915 N O Q1i a bond Me a bond NH S NH Q3c OH 916 N O Q1i abond Me a bond NH S a bond Q3a OH 917 N O Q1i a bond Me a bond NH S abond Q3b OH 918 N O Q1i a bond Me a bond NH S a bond Q3c OH 919 N O Q1ia bond Me a bond NH O NH Q3a OH 920 N O Q1i a bond Me a bond NH O NH Q3bOH 921 N O Q1i a bond Me a bond NH O NH Q3c OH 922 N O Q1i a bond Me abond NH O a bond Q3a OH 923 N O Q1i a bond Me a bond NH O a bond Q3b OH924 N O Q1i a bond Me a bond NH O a bond Q3c OH 925 N O Q1i a bond H abond NH S NH Q3a OH 926 N O Q1i a bond H a bond NH S NH Q3b OH 927 N OQ1i a bond H a bond NH S NH Q3c OH 928 N O Q1i a bond H a bond NH S abond Q3a OH 929 N O Q1i a bond H a bond NH S a bond Q3b OH 930 N O Q1i abond H a bond NH S a bond Q3c OH 931 N O Q1i a bond H a bond NH O NH Q3aOH 932 N O Q1i a bond H a bond NH O NH Q3b OH 933 N O Q1i a bond H abond NH O NH Q3c OH 934 N O Q1i a bond H a bond NH O a bond Q3a OH 935 NO Q1i a bond H a bond NH O a bond Q3b OH 936 N O Q1i a bond H a bond NHO a bond Q3c OH 937 N O Q1j a bond Me a bond NH S NH Q3a OH 938 N O Q1ja bond Me a bond NH S NH Q3b OH 939 N O Q1j a bond Me a bond NH S NH Q3cOH 940 N O Q1j a bond Me a bond NH S a bond Q3a OH 941 N O Q1j a bond Mea bond NH S a bond Q3b OH 942 N O Q1j a bond Me a bond NH S a bond Q3cOH 943 N O Q1j a bond Me a bond NH O NH Q3a OH 944 N O Q1j a bond Me abond NH O NH Q3b OH 945 N O Q1j a bond Me a bond NH O NH Q3c OH 946 N OQ1j a bond Me a bond NH O a bond Q3a OH 947 N O Q1j a bond Me a bond NHO a bond Q3b OH 948 N O Q1j a bond Me a bond NH O a bond Q3c OH 949 N OQ1j a bond H a bond NH S NH Q3a OH 950 N O Q1j a bond H a bond NH S NHQ3b OH 951 N O Q1j a bond H a bond NH S NH Q3c OH 952 N O Q1j a bond H abond NH S a bond Q3a OH 953 N O Q1j a bond H a bond NH S a bond Q3b OH954 N O Q1j a bond H a bond NH S a bond Q3c OH 955 N O Q1j a bond H abond NH O NH Q3a OH 956 N O Q1j a bond H a bond NH O NH Q3b OH 957 N OQ1j a bond H a bond NH O NH Q3c OH 958 N O Q1j a bond H a bond NH O abond Q3a OH 959 N O Q1j a bond H a bond NH O a bond Q3b OH 960 N O Q1j abond H a bond NH O a bond Q3c OH 961 CH NMe Q1a a bond Me a bond NH S NHQ3a OH 962 CH NMe Q1a a bond Me a bond NH S NH Q3b OH 963 CH NMe Q1a abond Me a bond NH S NH Q3c OH 964 CH NMe Q1a a bond Me a bond NH S abond Q3a OH 965 CH NMe Q1a a bond Me a bond NH S a bond Q3b OH 966 CHNMe Q1a a bond Me a bond NH S a bond Q3c OH 967 CH NMe Q1a a bond Me abond NH O NH Q3a OH 968 CH NMe Q1a a bond Me a bond NH O NH Q3b OH 969CH NMe Q1a a bond Me a bond NH O NH Q3c OH 970 CH NMe Q1a a bond Me abond NH O a bond Q3a OH 971 CH NMe Q1a a bond Me a bond NH O a bond Q3bOH 972 CH NMe Q1a a bond Me a bond NH O a bond Q3c OH 973 CH NMe Q1a abond H a bond NH S NH Q3a OH 974 CH NMe Q1a a bond H a bond NH S NH Q3bOH 975 CH NMe Q1a a bond H a bond NH S NH Q3c OH 976 CH NMe Q1a a bond Ha bond NH S a bond Q3a OH 977 CH NMe Q1a a bond H a bond NH S a bond Q3bOH 978 CH NMe Q1a a bond H a bond NH S a bond Q3c OH 979 CH NMe Q1a abond H a bond NH O NH Q3a OH 980 CH NMe Q1a a bond H a bond NH O NH Q3bOH 981 CH NMe Q1a a bond H a bond NH O NH Q3c OH 982 CH NMe Q1a a bond Ha bond NH O a bond Q3a OH 983 CH NMe Q1a a bond H a bond NH O a bond Q3bOH 984 CH NMe Q1a a bond H a bond NH O a bond Q3c OH 985 CH NMe Q1b abond Me a bond NH S NH Q3a OH 986 CH NMe Q1b a bond Me a bond NH S NHQ3b OH 987 CH NMe Q1b a bond Me a bond NH S NH Q3c OH 988 CH NMe Q1b abond Me a bond NH S a bond Q3a OH 989 CH NMe Q1b a bond Me a bond NH S abond Q3b OH 990 CH NMe Q1b a bond Me a bond NH S a bond Q3c OH 991 CHNMe Q1b a bond Me a bond NH O NH Q3a OH 992 CH NMe Q1b a bond Me a bondNH O NH Q3b OH 993 CH NMe Q1b a bond Me a bond NH O NH Q3c OH 994 CH NMeQ1b a bond Me a bond NH O a bond Q3a OH 995 CH NMe Q1b a bond Me a bondNH O a bond Q3b OH 996 CH NMe Q1b a bond Me a bond NH O a bond Q3c OH997 CH NMe Q1b a bond H a bond NH S NH Q3a OH 998 CH NMe Q1b a bond H abond NH S NH Q3b OH 999 CH NMe Q1b a bond H a bond NH S NH Q3c OH 1000CH NMe Q1b a bond H a bond NH S a bond Q3a OH 1001 CH NMe Q1b a bond H abond NH S a bond Q3b OH 1002 CH NMe Q1b a bond H a bond NH S a bond Q3cOH 1003 CH NMe Q1b a bond H a bond NH O NH Q3a OH 1004 CH NMe Q1b a bondH a bond NH O NH Q3b OH 1005 CH NMe Q1b a bond H a bond NH O NH Q3c OH1006 CH NMe Q1b a bond H a bond NH O a bond Q3a OH 1007 CH NMe Q1b abond H a bond NH O a bond Q3b OH 1008 CH NMe Q1b a bond H a bond NH O abond Q3c OH 1009 CH NMe Q1c a bond Me a bond NH S NH Q3a OH 1010 CH NMeQ1c a bond Me a bond NH S NH Q3b OH 1011 CH NMe Q1c a bond Me a bond NHS NH Q3c OH 1012 CH NMe Q1c a bond Me a bond NH S a bond Q3a OH 1013 CHNMe Q1c a bond Me a bond NH S a bond Q3b OH 1014 CH NMe Q1c a bond Me abond NH S a bond Q3c OH 1015 CH NMe Q1c a bond Me a bond NH O NH Q3a OH1016 CH NMe Q1c a bond Me a bond NH O NH Q3b OH 1017 CH NMe Q1c a bondMe a bond NH O NH Q3c OH 1018 CH NMe Q1c a bond Me a bond NH O a bondQ3a OH 1019 CH NMe Q1c a bond Me a bond NH O a bond Q3b OH 1020 CH NMeQ1c a bond Me a bond NH O a bond Q3c OH 1021 CH NMe Q1c a bond H a bondNH S NH Q3a OH 1022 CH NMe Q1c a bond H a bond NH S NH Q3b OH 1023 CHNMe Q1c a bond H a bond NH S NH Q3c OH 1024 CH NMe Q1c a bond H a bondNH S a bond Q3a OH 1025 CH NMe Q1c a bond H a bond NH S a bond Q3b OH1026 CH NMe Q1c a bond H a bond NH S a bond Q3c OH 1027 CH NMe Q1c abond H a bond NH O NH Q3a OH 1028 CH NMe Q1c a bond H a bond NH O NH Q3bOH 1029 CH NMe Q1c a bond H a bond NH O NH Q3c OH 1030 CH NMe Q1c a bondH a bond NH O a bond Q3a OH 1031 CH NMe Q1c a bond H a bond NH O a bondQ3b OH 1032 CH NMe Q1c a bond H a bond NH O a bond Q3c OH 1033 CH NMeQ1d a bond Me a bond NH S NH Q3a OH 1034 CH NMe Q1d a bond Me a bond NHS NH Q3b OH 1035 CH NMe Q1d a bond Me a bond NH S NH Q3c OH 1036 CH NMeQ1d a bond Me a bond NH S a bond Q3a OH 1037 CH NMe Q1d a bond Me a bondNH S a bond Q3b OH 1038 CH NMe Q1d a bond Me a bond NH S a bond Q3c OH1039 CH NMe Q1d a bond Me a bond NH O NH Q3a OH 1040 CH NMe Q1d a bondMe a bond NH O NH Q3b OH 1041 CH NMe Q1d a bond Me a bond NH O NH Q3c OH1042 CH NMe Q1d a bond Me a bond NH O a bond Q3a OH 1043 CH NMe Q1d abond Me a bond NH O a bond Q3b OH 1044 CH NMe Q1d a bond Me a bond NH Oa bond Q3c OH 1045 CH NMe Q1d a bond H a bond NH S NH Q3a OH 1046 CH NMeQ1d a bond H a bond NH S NH Q3b OH 1047 CH NMe Q1d a bond H a bond NH SNH Q3c OH 1048 CH NMe Q1d a bond H a bond NH S a bond Q3a OH 1049 CH NMeQ1d a bond H a bond NH S a bond Q3b OH 1050 CH NMe Q1d a bond H a bondNH S a bond Q3c OH 1051 CH NMe Q1d a bond H a bond NH O NH Q3a OH 1052CH NMe Q1d a bond H a bond NH O NH Q3b OH 1053 CH NMe Q1d a bond H abond NH O NH Q3c OH 1054 CH NMe Q1d a bond H a bond NH O a bond Q3a OH1055 CH NMe Q1d a bond H a bond NH O a bond Q3b OH 1056 CH NMe Q1d abond H a bond NH O a bond Q3c OH 1057 CH NMe Q1e a bond Me a bond NH SNH Q3a OH 1058 CH NMe Q1e a bond Me a bond NH S NH Q3b OH 1059 CH NMeQ1e a bond Me a bond NH S NH Q3c OH 1060 CH NMe Q1e a bond Me a bond NHS a bond Q3a OH 1061 CH NMe Q1e a bond Me a bond NH S a bond Q3b OH 1062CH NMe Q1e a bond Me a bond NH S a bond Q3c OH 1063 CH NMe Q1e a bond Mea bond NH O NH Q3a OH 1064 CH NMe Q1e a bond Me a bond NH O NH Q3b OH1065 CH NMe Q1e a bond Me a bond NH O NH Q3c OH 1066 CH NMe Q1e a bondMe a bond NH O a bond Q3a OH 1067 CH NMe Q1e a bond Me a bond NH O abond Q3b OH 1068 CH NMe Q1e a bond Me a bond NH O a bond Q3c OH 1069 CHNMe Q1e a bond H a bond NH S NH Q3a OH 1070 CH NMe Q1e a bond H a bondNH S NH Q3b OH 1071 CH NMe Q1e a bond H a bond NH S NH Q3c OH 1072 CHNMe Q1e a bond H a bond NH S a bond Q3a OH 1073 CH NMe Q1e a bond H abond NH S a bond Q3b OH 1074 CH NMe Q1e a bond H a bond NH S a bond Q3cOH 1075 CH NMe Q1e a bond H a bond NH O NH Q3a OH 1076 CH NMe Q1e a bondH a bond NH O NH Q3b OH 1077 CH NMe Q1e a bond H a bond NH O NH Q3c OH1078 CH NMe Q1e a bond H a bond NH O a bond Q3a OH 1079 CH NMe Q1e abond H a bond NH O a bond Q3b OH 1080 CH NMe Q1e a bond H a bond NH O abond Q3c OH 1081 CH NMe Q1f a bond Me a bond NH S NH Q3a OH 1082 CH NMeQ1f a bond Me a bond NH S NH Q3b OH 1083 CH NMe Q1f a bond Me a bond NHS NH Q3c OH 1084 CH NMe Q1f a bond Me a bond NH S a bond Q3a OH 1085 CHNMe Q1f a bond Me a bond NH S a bond Q3b OH 1086 CH NMe Q1f a bond Me abond NH S a bond Q3c OH 1087 CH NMe Q1f a bond Me a bond NH O NH Q3a OH1088 CH NMe Q1f a bond Me a bond NH O NH Q3b OH 1089 CH NMe Q1f a bondMe a bond NH O NH Q3c OH 1090 CH NMe Q1f a bond Me a bond NH O a bondQ3a OH 1091 CH NMe Q1f a bond Me a bond NH O a bond Q3b OH 1092 CH NMeQ1f a bond Me a bond NH O a bond Q3c OH 1093 CH NMe Q1f a bond H a bondNH S NH Q3a OH 1094 CH NMe Q1f a bond H a bond NH S NH Q3b OH 1095 CHNMe Q1f a bond H a bond NH S NH Q3c OH 1096 CH NMe Q1f a bond H a bondNH S a bond Q3a OH 1097 CH NMe Q1f a bond H a bond NH S a bond Q3b OH1098 CH NMe Q1f a bond H a bond NH S a bond Q3c OH 1099 CH NMe Q1f abond H a bond NH O NH Q3a OH 1100 CH NMe Q1f a bond H a bond NH O NH Q3bOH 1101 CH NMe Q1f a bond H a bond NH O NH Q3c OH 1102 CH NMe Q1f a bondH a bond NH O a bond Q3a OH 1103 CH NMe Q1f a bond H a bond NH O a bondQ3b OH 1104 CH NMe Q1f a bond H a bond NH O a bond Q3c OH 1105 CH NMeQ1g a bond Me a bond NH S NH Q3a OH 1106 CH NMe Q1g a bond Me a bond NHS NH Q3b OH 1107 CH NMe Q1g a bond Me a bond NH S NH Q3c OH 1108 CH NMeQ1g a bond Me a bond NH S a bond Q3a OH 1109 CH NMe Q1g a bond Me a bondNH S a bond Q3b OH 1110 CH NMe Q1g a bond Me a bond NH S a bond Q3c OH1111 CH NMe Q1g a bond Me a bond NH O NH Q3a OH 1112 CH NMe Q1g a bondMe a bond NH O NH Q3b OH 1113 CH NMe Q1g a bond Me a bond NH O NH Q3c OH1114 CH NMe Q1g a bond Me a bond NH O a bond Q3a OH 1115 CH NMe Q1g abond Me a bond NH O a bond Q3b OH 1116 CH NMe Q1g a bond Me a bond NH Oa bond Q3c OH 1117 CH NMe Q1g a bond H a bond NH S NH Q3a OH 1118 CH NMeQ1g a bond H a bond NH S NH Q3b OH 1119 CH NMe Q1g a bond H a bond NH SNH Q3c OH 1120 CH NMe Q1g a bond H a bond NH S a bond Q3a OH 1121 CH NMeQ1g a bond H a bond NH S a bond Q3b OH 1122 CH NMe Q1g a bond H a bondNH S a bond Q3c OH 1123 CH NMe Q1g a bond H a bond NH O NH Q3a OH 1124CH NMe Q1g a bond H a bond NH O NH Q3b OH 1125 CH NMe Q1g a bond H abond NH O NH Q3c OH 1126 CH NMe Q1g a bond H a bond NH O a bond Q3a OH1127 CH NMe Q1g a bond H a bond NH O a bond Q3b OH 1128 CH NMe Q1g abond H a bond NH O a bond Q3c OH 1129 CH NMe Q1h a bond Me a bond NH SNH Q3a OH 1130 CH NMe Q1h a bond Me a bond NH S NH Q3b OH 1131 CH NMeQ1h a bond Me a bond NH S NH Q3c OH 1132 CH NMe Q1h a bond Me a bond NHS a bond Q3a OH 1133 CH NMe Q1h a bond Me a bond NH S a bond Q3b OH 1134CH NMe Q1h a bond Me a bond NH S a bond Q3c OH 1135 CH NMe Q1h a bond Mea bond NH O NH Q3a OH 1136 CH NMe Q1h a bond Me a bond NH O NH Q3b OH1137 CH NMe Q1h a bond Me a bond NH O NH Q3c OH 1138 CH NMe Q1h a bondMe a bond NH O a bond Q3a OH 1139 CH NMe Q1h a bond Me a bond NH O abond Q3b OH 1140 CH NMe Q1h a bond Me a bond NH O a bond Q3c OH 1141 CHNMe Q1h a bond H a bond NH S NH Q3a OH 1142 CH NMe Q1h a bond H a bondNH S NH Q3b OH 1143 CH NMe Q1h a bond H a bond NH S NH Q3c OH 1144 CHNMe Q1h a bond H a bond NH S a bond Q3a OH 1145 CH NMe Q1h a bond H abond NH S a bond Q3b OH 1146 CH NMe Q1h a bond H a bond NH S a bond Q3cOH 1147 CH NMe Q1h a bond H a bond NH O NH Q3a OH 1148 CH NMe Q1h a bondH a bond NH O NH Q3b OH 1149 CH NMe Q1h a bond H a bond NH O NH Q3c OH1150 CH NMe Q1h a bond H a bond NH O a bond Q3a OH 1151 CH NMe Q1h abond H a bond NH O a bond Q3b OH 1152 CH NMe Q1h a bond H a bond NH O abond Q3c OH 1153 CH NMe Q1i a bond Me a bond NH S NH Q3a OH 1154 CH NMeQ1i a bond Me a bond NH S NH Q3b OH 1155 CH NMe Q1i a bond Me a bond NHS NH Q3c OH 1156 CH NMe Q1i a bond Me a bond NH S a bond Q3a OH 1157 CHNMe Q1i a bond Me a bond NH S a bond Q3b OH 1158 CH NMe Q1i a bond Me abond NH S a bond Q3c OH 1159 CH NMe Q1i a bond Me a bond NH O NH Q3a OH1160 CH NMe Q1i a bond Me a bond NH O NH Q3b OH 1161 CH NMe Q1i a bondMe a bond NH O NH Q3c OH 1162 CH NMe Q1i a bond Me a bond NH O a bondQ3a OH 1163 CH NMe Q1i a bond Me a bond NH O a bond Q3b OH 1164 CH NMeQ1i a bond Me a bond NH O a bond Q3c OH 1165 CH NMe Q1i a bond H a bondNH S NH Q3a OH 1166 CH NMe Q1i a bond H a bond NH S NH Q3b OH 1167 CHNMe Q1i a bond H a bond NH S NH Q3c OH 1168 CH NMe Q1i a bond H a bondNH S a bond Q3a OH 1169 CH NMe Q1i a bond H a bond NH S a bond Q3b OH1170 CH NMe Q1i a bond H a bond NH S a bond Q3c OH 1171 CH NMe Q1i abond H a bond NH O NH Q3a OH 1172 CH NMe Q1i a bond H a bond NH O NH Q3bOH 1173 CH NMe Q1i a bond H a bond NH O NH Q3c OH 1174 CH NMe Q1i a bondH a bond NH O a bond Q3a OH 1175 CH NMe Q1i a bond H a bond NH O a bondQ3b OH 1176 CH NMe Q1i a bond H a bond NH O a bond Q3c OH 1177 CH NMeQ1j a bond Me a bond NH S NH Q3a OH 1178 CH NMe Q1j a bond Me a bond NHS NH Q3b OH 1179 CH NMe Q1j a bond Me a bond NH S NH Q3c OH 1180 CH NMeQ1j a bond Me a bond NH S a bond Q3a OH 1181 CH NMe Q1j a bond Me a bondNH S a bond Q3b OH 1182 CH NMe Q1j a bond Me a bond NH S a bond Q3c OH1183 CH NMe Q1j a bond Me a bond NH O NH Q3a OH 1184 CH NMe Q1j a bondMe a bond NH O NH Q3b OH 1185 CH NMe Q1j a bond Me a bond NH O NH Q3c OH1186 CH NMe Q1j a bond Me a bond NH O a bond Q3a OH 1187 CH NMe Q1j abond Me a bond NH O a bond Q3b OH 1188 CH NMe Q1j a bond Me a bond NH Oa bond Q3c OH 1189 CH NMe Q1j a bond H a bond NH S NH Q3a OH 1190 CH NMeQ1j a bond H a bond NH S NH Q3b OH 1191 CH NMe Q1j a bond H a bond NH SNH Q3c OH 1192 CH NMe Q1j a bond H a bond NH S a bond Q3a OH 1193 CH NMeQ1j a bond H a bond NH S a bond Q3b OH 1194 CH NMe Q1j a bond H a bondNH S a bond Q3c OH 1195 CH NMe Q1j a bond H a bond NH O NH Q3a OH 1196CH NMe Q1j a bond H a bond NH O NH Q3b OH 1197 CH NMe Q1j a bond H abond NH O NH Q3c OH 1198 CH NMe Q1j a bond H a bond NH O a bond Q3a OH1199 CH NMe Q1j a bond H a bond NH O a bond Q3b OH 1200 CH NMe Q1j abond H a bond NH O a bond Q3c OH 1201 CH NEt Q1a a bond Me a bond NH SNH Q3a OH 1202 CH NEt Q1a a bond Me a bond NH S NH Q3b OH 1203 CH NEtQ1a a bond Me a bond NH S NH Q3c OH 1204 CH NEt Q1a a bond Me a bond NHS a bond Q3a OH 1205 CH NEt Q1a a bond Me a bond NH S a bond Q3b OH 1206CH NEt Q1a a bond Me a bond NH S a bond Q3c OH 1207 CH NEt Q1a a bond Mea bond NH O NH Q3a OH 1208 CH NEt Q1a a bond Me a bond NH O NH Q3b OH1209 CH NEt Q1a a bond Me a bond NH O NH Q3c OH 1210 CH NEt Q1a a bondMe a bond NH O a bond Q3a OH 1211 CH NEt Q1a a bond Me a bond NH O abond Q3b OH 1212 CH NEt Q1a a bond Me a bond NH O a bond Q3c OH 1213 CHNEt Q1a a bond H a bond NH S NH Q3a OH 1214 CH NEt Q1a a bond H a bondNH S NH Q3b OH 1215 CH NEt Q1a a bond H a bond NH S NH Q3c OH 1216 CHNEt Q1a a bond H a bond NH S a bond Q3a OH 1217 CH NEt Q1a a bond H abond NH S a bond Q3b OH 1218 CH NEt Q1a a bond H a bond NH S a bond Q3cOH 1219 CH NEt Q1a a bond H a bond NH O NH Q3a OH 1220 CH NEt Q1a a bondH a bond NH O NH Q3b OH 1221 CH NEt Q1a a bond H a bond NH O NH Q3c OH1222 CH NEt Q1a a bond H a bond NH O a bond Q3a OH 1223 CH NEt Q1a abond H a bond NH O a bond Q3b OH 1224 CH NEt Q1a a bond H a bond NH O abond Q3c OH 1225 CH NEt Q1b a bond Me a bond NH S NH Q3a OH 1226 CH NEtQ1b a bond Me a bond NH S NH Q3b OH 1227 CH NEt Q1b a bond Me a bond NHS NH Q3c OH 1228 CH NEt Q1b a bond Me a bond NH S a bond Q3a OH 1229 CHNEt Q1b a bond Me a bond NH S a bond Q3b OH 1230 CH NEt Q1b a bond Me abond NH S a bond Q3c OH 1231 CH NEt Q1b a bond Me a bond NH O NH Q3a OH1232 CH NEt Q1b a bond Me a bond NH O NH Q3b OH 1233 CH NEt Q1b a bondMe a bond NH O NH Q3c OH 1234 CH NEt Q1b a bond Me a bond NH O a bondQ3a OH 1235 CH NEt Q1b a bond Me a bond NH O a bond Q3b OH 1236 CH NEtQ1b a bond Me a bond NH O a bond Q3c OH 1237 CH NEt Q1b a bond H a bondNH S NH Q3a OH 1238 CH NEt Q1b a bond H a bond NH S NH Q3b OH 1239 CHNEt Q1b a bond H a bond NH S NH Q3c OH 1240 CH NEt Q1b a bond H a bondNH S a bond Q3a OH 1241 CH NEt Q1b a bond H a bond NH S a bond Q3b OH1242 CH NEt Q1b a bond H a bond NH S a bond Q3c OH 1243 CH NEt Q1b abond H a bond NH O NH Q3a OH 1244 CH NEt Q1b a bond H a bond NH O NH Q3bOH 1245 CH NEt Q1b a bond H a bond NH O NH Q3c OH 1246 CH NEt Q1b a bondH a bond NH O a bond Q3a OH 1247 CH NEt Q1b a bond H a bond NH O a bondQ3b OH 1248 CH NEt Q1b a bond H a bond NH O a bond Q3c OH 1249 CH NEtQ1c a bond Me a bond NH S NH Q3a OH 1250 CH NEt Q1c a bond Me a bond NHS NH Q3b OH 1251 CH NEt Q1c a bond Me a bond NH S NH Q3c OH 1252 CH NEtQ1c a bond Me a bond NH S a bond Q3a OH 1253 CH NEt Q1c a bond Me a bondNH S a bond Q3b OH 1254 CH NEt Q1c a bond Me a bond NH S a bond Q3c OH1255 CH NEt Q1c a bond Me a bond NH O NH Q3a OH 1256 CH NEt Q1c a bondMe a bond NH O NH Q3b OH 1257 CH NEt Q1c a bond Me a bond NH O NH Q3c OH1258 CH NEt Q1c a bond Me a bond NH O a bond Q3a OH 1259 CH NEt Q1c abond Me a bond NH O a bond Q3b OH 1260 CH NEt Q1c a bond Me a bond NH Oa bond Q3c OH 1261 CH NEt Q1c a bond H a bond NH S NH Q3a OH 1262 CH NEtQ1c a bond H a bond NH S NH Q3b OH 1263 CH NEt Q1c a bond H a bond NH SNH Q3c OH 1264 CH NEt Q1c a bond H a bond NH S a bond Q3a OH 1265 CH NEtQ1c a bond H a bond NH S a bond Q3b OH 1266 CH NEt Q1c a bond H a bondNH S a bond Q3c OH 1267 CH NEt Q1c a bond H a bond NH O NH Q3a OH 1268CH NEt Q1c a bond H a bond NH O NH Q3b OH 1269 CH NEt Q1c a bond H abond NH O NH Q3c OH 1270 CH NEt Q1c a bond H a bond NH O a bond Q3a OH1271 CH NEt Q1c a bond H a bond NH O a bond Q3b OH 1272 CH NEt Q1c abond H a bond NH O a bond Q3c OH 1273 CH NEt Q1d a bond Me a bond NH SNH Q3a OH 1274 CH NEt Q1d a bond Me a bond NH S NH Q3b OH 1275 CH NEtQ1d a bond Me a bond NH S NH Q3c OH 1276 CH NEt Q1d a bond Me a bond NHS a bond Q3a OH 1277 CH NEt Q1d a bond Me a bond NH S a bond Q3b OH 1278CH NEt Q1d a bond Me a bond NH S a bond Q3c OH 1279 CH NEt Q1d a bond Mea bond NH O NH Q3a OH 1280 CH NEt Q1d a bond Me a bond NH O NH Q3b OH1281 CH NEt Q1d a bond Me a bond NH O NH Q3c OH 1282 CH NEt Q1d a bondMe a bond NH O a bond Q3a OH 1283 CH NEt Q1d a bond Me a bond NH O abond Q3b OH 1284 CH NEt Q1d a bond Me a bond NH O a bond Q3c OH 1285 CHNEt Q1d a bond H a bond NH S NH Q3a OH 1286 CH NEt Q1d a bond H a bondNH S NH Q3b OH 1287 CH NEt Q1d a bond H a bond NH S NH Q3c OH 1288 CHNEt Q1d a bond H a bond NH S a bond Q3a OH 1289 CH NEt Q1d a bond H abond NH S a bond Q3b OH 1290 CH NEt Q1d a bond H a bond NH S a bond Q3cOH 1291 CH NEt Q1d a bond H a bond NH O NH Q3a OH 1292 CH NEt Q1d a bondH a bond NH O NH Q3b OH 1293 CH NEt Q1d a bond H a bond NH O NH Q3c OH1294 CH NEt Q1d a bond H a bond NH O a bond Q3a OH 1295 CH NEt Q1d abond H a bond NH O a bond Q3b OH 1296 CH NEt Q1d a bond H a bond NH O abond Q3c OH 1297 CH NEt Q1e a bond Me a bond NH S NH Q3a OH 1298 CH NEtQ1e a bond Me a bond NH S NH Q3b OH 1299 CH NEt Q1e a bond Me a bond NHS NH Q3c OH 1300 CH NEt Q1e a bond Me a bond NH S a bond Q3a OH 1301 CHNEt Q1e a bond Me a bond NH S a bond Q3b OH 1302 CH NEt Q1e a bond Me abond NH S a bond Q3c OH 1303 CH NEt Q1e a bond Me a bond NH O NH Q3a OH1304 CH NEt Q1e a bond Me a bond NH O NH Q3b OH 1305 CH NEt Q1e a bondMe a bond NH O NH Q3c OH 1306 CH NEt Q1e a bond Me a bond NH O a bondQ3a OH 1307 CH NEt Q1e a bond Me a bond NH O a bond Q3b OH 1308 CH NEtQ1e a bond Me a bond NH O a bond Q3c OH 1309 CH NEt Q1e a bond H a bondNH S NH Q3a OH 1310 CH NEt Q1e a bond H a bond NH S NH Q3b OH 1311 CHNEt Q1e a bond H a bond NH S NH Q3c OH 1312 CH NEt Q1e a bond H a bondNH S a bond Q3a OH 1313 CH NEt Q1e a bond H a bond NH S a bond Q3b OH1314 CH NEt Q1e a bond H a bond NH S a bond Q3c OH 1315 CH NEt Q1e abond H a bond NH O NH Q3a OH 1316 CH NEt Q1e a bond H a bond NH O NH Q3bOH 1317 CH NEt Q1e a bond H a bond NH O NH Q3c OH 1318 CH NEt Q1e a bondH a bond NH O a bond Q3a OH 1319 CH NEt Q1e a bond H a bond NH O a bondQ3b OH 1320 CH NEt Q1e a bond H a bond NH O a bond Q3c OH 1321 CH NEtQ1f a bond Me a bond NH S NH Q3a OH 1322 CH NEt Q1f a bond Me a bond NHS NH Q3b OH 1323 CH NEt Q1f a bond Me a bond NH S NH Q3c OH 1324 CH NEtQ1f a bond Me a bond NH S a bond Q3a OH 1325 CH NEt Q1f a bond Me a bondNH S a bond Q3b OH 1326 CH NEt Q1f a bond Me a bond NH S a bond Q3c OH1327 CH NEt Q1f a bond Me a bond NH O NH Q3a OH 1328 CH NEt Q1f a bondMe a bond NH O NH Q3b OH 1329 CH NEt Q1f a bond Me a bond NH O NH Q3c OH1330 CH NEt Q1f a bond Me a bond NH O a bond Q3a OH 1331 CH NEt Q1f abond Me a bond NH O a bond Q3b OH 1332 CH NEt Q1f a bond Me a bond NH Oa bond Q3c OH 1333 CH NEt Q1f a bond H a bond NH S NH Q3a OH 1334 CH NEtQ1f a bond H a bond NH S NH Q3b OH 1335 CH NEt Q1f a bond H a bond NH SNH Q3c OH 1336 CH NEt Q1f a bond H a bond NH S a bond Q3a OH 1337 CH NEtQ1f a bond H a bond NH S a bond Q3b OH 1338 CH NEt Q1f a bond H a bondNH S a bond Q3c OH 1339 CH NEt Q1f a bond H a bond NH O NH Q3a OH 1340CH NEt Q1f a bond H a bond NH O NH Q3b OH 1341 CH NEt Q1f a bond H abond NH O NH Q3c OH 1342 CH NEt Q1f a bond H a bond NH O a bond Q3a OH1343 CH NEt Q1f a bond H a bond NH O a bond Q3b OH 1344 CH NEt Q1f abond H a bond NH O a bond Q3c OH 1345 CH NEt Q1g a bond Me a bond NH SNH Q3a OH 1346 CH NEt Q1g a bond Me a bond NH S NH Q3b OH 1347 CH NEtQ1g a bond Me a bond NH S NH Q3c OH 1348 CH NEt Q1g a bond Me a bond NHS a bond Q3a OH 1349 CH NEt Q1g a bond Me a bond NH S a bond Q3b OH 1350CH NEt Q1g a bond Me a bond NH S a bond Q3c OH 1351 CH NEt Q1g a bond Mea bond NH O NH Q3a OH 1352 CH NEt Q1g a bond Me a bond NH O NH Q3b OH1353 CH NEt Q1g a bond Me a bond NH O NH Q3c OH 1354 CH NEt Q1g a bondMe a bond NH O a bond Q3a OH 1355 CH NEt Q1g a bond Me a bond NH O abond Q3b OH 1356 CH NEt Q1g a bond Me a bond NH O a bond Q3c OH 1357 CHNEt Q1g a bond H a bond NH S NH Q3a OH 1358 CH NEt Q1g a bond H a bondNH S NH Q3b OH 1359 CH NEt Q1g a bond H a bond NH S NH Q3c OH 1360 CHNEt Q1g a bond H a bond NH S a bond Q3a OH 1361 CH NEt Q1g a bond H abond NH S a bond Q3b OH 1362 CH NEt Q1g a bond H a bond NH S a bond Q3cOH 1363 CH NEt Q1g a bond H a bond NH O NH Q3a OH 1364 CH NEt Q1g a bondH a bond NH O NH Q3b OH 1365 CH NEt Q1g a bond H a bond NH O NH Q3c OH1366 CH NEt Q1g a bond H a bond NH O a bond Q3a OH 1367 CH NEt Q1g abond H a bond NH O a bond Q3b OH 1368 CH NEt Q1g a bond H a bond NH O abond Q3c OH 1369 CH NEt Q1h a bond Me a bond NH S NH Q3a OH 1370 CH NEtQ1h a bond Me a bond NH S NH Q3b OH 1371 CH NEt Q1h a bond Me a bond NHS NH Q3c OH 1372 CH NEt Q1h a bond Me a bond NH S a bond Q3a OH 1373 CHNEt Q1h a bond Me a bond NH S a bond Q3b OH 1374 CH NEt Q1h a bond Me abond NH S a bond Q3c OH 1375 CH NEt Q1h a bond Me a bond NH O NH Q3a OH1376 CH NEt Q1h a bond Me a bond NH O NH Q3b OH 1377 CH NEt Q1h a bondMe a bond NH O NH Q3c OH 1378 CH NEt Q1h a bond Me a bond NH O a bondQ3a OH 1379 CH NEt Q1h a bond Me a bond NH O a bond Q3b OH 1380 CH NEtQ1h a bond Me a bond NH O a bond Q3c OH 1381 CH NEt Q1h a bond H a bondNH S NH Q3a OH 1382 CH NEt Q1h a bond H a bond NH S NH Q3b OH 1383 CHNEt Q1h a bond H a bond NH S NH Q3c OH 1384 CH NEt Q1h a bond H a bondNH S a bond Q3a OH 1385 CH NEt Q1h a bond H a bond NH S a bond Q3b OH1386 CH NEt Q1h a bond H a bond NH S a bond Q3c OH 1387 CH NEt Q1h abond H a bond NH O NH Q3a OH 1388 CH NEt Q1h a bond H a bond NH O NH Q3bOH 1389 CH NEt Q1h a bond H a bond NH O NH Q3c OH 1390 CH NEt Q1h a bondH a bond NH O a bond Q3a OH 1391 CH NEt Q1h a bond H a bond NH O a bondQ3b OH 1392 CH NEt Q1h a bond H a bond NH O a bond Q3c OH 1393 CH NEtQ1i a bond Me a bond NH S NH Q3a OH 1394 CH NEt Q1i a bond Me a bond NHS NH Q3b OH 1395 CH NEt Q1i a bond Me a bond NH S NH Q3c OH 1396 CH NEtQ1i a bond Me a bond NH S a bond Q3a OH 1397 CH NEt Q1i a bond Me a bondNH S a bond Q3b OH 1398 CH NEt Q1i a bond Me a bond NH S a bond Q3c OH1399 CH NEt Q1i a bond Me a bond NH O NH Q3a OH 1400 CH NEt Q1i a bondMe a bond NH O NH Q3b OH 1401 CH NEt Q1i a bond Me a bond NH O NH Q3c OH1402 CH NEt Q1i a bond Me a bond NH O a bond Q3a OH 1403 CH NEt Q1i abond Me a bond NH O a bond Q3b OH 1404 CH NEt Q1i a bond Me a bond NH Oa bond Q3c OH 1405 CH NEt Q1i a bond H a bond NH S NH Q3a OH 1406 CH NEtQ1i a bond H a bond NH S NH Q3b OH 1407 CH NEt Q1i a bond H a bond NH SNH Q3c OH 1408 CH NEt Q1i a bond H a bond NH S a bond Q3a OH 1409 CH NEtQ1i a bond H a bond NH S a bond Q3b OH 1410 CH NEt Q1i a bond H a bondNH S a bond Q3c OH 1411 CH NEt Q1i a bond H a bond NH O NH Q3a OH 1412CH NEt Q1i a bond H a bond NH O NH Q3b OH 1413 CH NEt Q1i a bond H abond NH O NH Q3c OH 1414 CH NEt Q1i a bond H a bond NH O a bond Q3a OH1415 CH NEt Q1i a bond H a bond NH O a bond Q3b OH 1416 CH NEt Q1i abond H a bond NH O a bond Q3c OH 1417 CH NEt Q1j a bond Me a bond NH SNH Q3a OH 1418 CH NEt Q1j a bond Me a bond NH S NH Q3b OH 1419 CH NEtQ1j a bond Me a bond NH S NH Q3c OH 1420 CH NEt Q1j a bond Me a bond NHS a bond Q3a OH 1421 CH NEt Q1j a bond Me a bond NH S a bond Q3b OH 1422CH NEt Q1j a bond Me a bond NH S a bond Q3c OH 1423 CH NEt Q1j a bond Mea bond NH O NH Q3a OH 1424 CH NEt Q1j a bond Me a bond NH O NH Q3b OH1425 CH NEt Q1j a bond Me a bond NH O NH Q3c OH 1426 CH NEt Q1j a bondMe a bond NH O a bond Q3a OH 1427 CH NEt Q1j a bond Me a bond NH O abond Q3b OH 1428 CH NEt Q1j a bond Me a bond NH O a bond Q3c OH 1429 CHNEt Q1j a bond H a bond NH S NH Q3a OH 1430 CH NEt Q1j a bond H a bondNH S NH Q3b OH 1431 CH NEt Q1j a bond H a bond NH S NH Q3c OH 1432 CHNEt Q1j a bond H a bond NH S a bond Q3a OH 1433 CH NEt Q1j a bond H abond NH S a bond Q3b OH 1434 CH NEt Q1j a bond H a bond NH S a bond Q3cOH 1435 CH NEt Q1j a bond H a bond NH O NH Q3a OH 1436 CH NEt Q1j a bondH a bond NH O NH Q3b OH 1437 CH NEt Q1j a bond H a bond NH O NH Q3c OH1438 CH NEt Q1j a bond H a bond NH O a bond Q3a OH 1439 CH NEt Q1j abond H a bond NH O a bond Q3b OH 1440 CH NEt Q1j a bond H a bond NH O abond Q3c OH 1441 CH S Q1a a bond Me a bond NH S NH Q3a OH 1442 CH S Q1aa bond Me a bond NH S NH Q3b OH 1443 CH S Q1a a bond Me a bond NH S NHQ3c OH 1444 CH S Q1a a bond Me a bond NH S a bond Q3a OH 1445 CH S Q1a abond Me a bond NH S a bond Q3b OH 1446 CH S Q1a a bond Me a bond NH S abond Q3c OH 1447 CH S Q1a a bond Me a bond NH O NH Q3a OH 1448 CH S Q1aa bond Me a bond NH O NH Q3b OH 1449 CH S Q1a a bond Me a bond NH O NHQ3c OH 1450 CH S Q1a a bond Me a bond NH O a bond Q3a OH 1451 CH S Q1a abond Me a bond NH O a bond Q3b OH 1452 CH S Q1a a bond Me a bond NH O abond Q3c OH 1453 CH S Q1a a bond H a bond NH S NH Q3a OH 1454 CH S Q1a abond H a bond NH S NH Q3b OH 1455 CH S Q1a a bond H a bond NH S NH Q3cOH 1456 CH S Q1a a bond H a bond NH S a bond Q3a OH 1457 CH S Q1a a bondH a bond NH S a bond Q3b OH 1458 CH S Q1a a bond H a bond NH S a bondQ3c OH 1459 CH S Q1a a bond H a bond NH O NH Q3a OH 1460 CH S Q1a a bondH a bond NH O NH Q3b OH 1461 CH S Q1a a bond H a bond NH O NH Q3c OH1462 CH S Q1a a bond H a bond NH O a bond Q3a OH 1463 CH S Q1a a bond Ha bond NH O a bond Q3b OH 1464 CH S Q1a a bond H a bond NH O a bond Q3cOH 1465 CH S Q1b a bond Me a bond NH S NH Q3a OH 1466 CH S Q1b a bond Mea bond NH S NH Q3b OH 1467 CH S Q1b a bond Me a bond NH S NH Q3c OH 1468CH S Q1b a bond Me a bond NH S a bond Q3a OH 1469 CH S Q1b a bond Me abond NH S a bond Q3b OH 1470 CH S Q1b a bond Me a bond NH S a bond Q3cOH 1471 CH S Q1b a bond Me a bond NH O NH Q3a OH 1472 CH S Q1b a bond Mea bond NH O NH Q3b OH 1473 CH S Q1b a bond Me a bond NH O NH Q3c OH 1474CH S Q1b a bond Me a bond NH O a bond Q3a OH 1475 CH S Q1b a bond Me abond NH O a bond Q3b OH 1476 CH S Q1b a bond Me a bond NH O a bond Q3cOH 1477 CH S Q1b a bond H a bond NH S NH Q3a OH 1478 CH S Q1b a bond H abond NH S NH Q3b OH 1479 CH S Q1b a bond H a bond NH S NH Q3c OH 1480 CHS Q1b a bond H a bond NH S a bond Q3a OH 1481 CH S Q1b a bond H a bondNH S a bond Q3b OH 1482 CH S Q1b a bond H a bond NH S a bond Q3c OH 1483CH S Q1b a bond H a bond NH O NH Q3a OH 1484 CH S Q1b a bond H a bond NHO NH Q3b OH 1485 CH S Q1b a bond H a bond NH O NH Q3c OH 1486 CH S Q1b abond H a bond NH O a bond Q3a OH 1487 CH S Q1b a bond H a bond NH O abond Q3b OH 1488 CH S Q1b a bond H a bond NH O a bond Q3c OH 1489 CH SQ1c a bond Me a bond NH S NH Q3a OH 1490 CH S Q1c a bond Me a bond NH SNH Q3b OH 1491 CH S Q1c a bond Me a bond NH S NH Q3c OH 1492 CH S Q1c abond Me a bond NH S a bond Q3a OH 1493 CH S Q1c a bond Me a bond NH S abond Q3b OH 1494 CH S Q1c a bond Me a bond NH S a bond Q3c OH 1495 CH SQ1c a bond Me a bond NH O NH Q3a OH 1496 CH S Q1c a bond Me a bond NH ONH Q3b OH 1497 CH S Q1c a bond Me a bond NH O NH Q3c OH 1498 CH S Q1c abond Me a bond NH O a bond Q3a OH 1499 CH S Q1c a bond Me a bond NH O abond Q3b OH 1500 CH S Q1c a bond Me a bond NH O a bond Q3c OH 1501 CH SQ1c a bond H a bond NH S NH Q3a OH 1502 CH S Q1c a bond H a bond NH S NHQ3b OH 1503 CH S Q1c a bond H a bond NH S NH Q3c OH 1504 CH S Q1c a bondH a bond NH S a bond Q3a OH 1505 CH S Q1c a bond H a bond NH S a bondQ3b OH 1506 CH S Q1c a bond H a bond NH S a bond Q3c OH 1507 CH S Q1c abond H a bond NH O NH Q3a OH 1508 CH S Q1c a bond H a bond NH O NH Q3bOH 1509 CH S Q1c a bond H a bond NH O NH Q3c OH 1510 CH S Q1c a bond H abond NH O a bond Q3a OH 1511 CH S Q1c a bond H a bond NH O a bond Q3b OH1512 CH S Q1c a bond H a bond NH O a bond Q3c OH 1513 CH S Q1d a bond Mea bond NH S NH Q3a OH 1514 CH S Q1d a bond Me a bond NH S NH Q3b OH 1515CH S Q1d a bond Me a bond NH S NH Q3c OH 1516 CH S Q1d a bond Me a bondNH S a bond Q3a OH 1517 CH S Q1d a bond Me a bond NH S a bond Q3b OH1518 CH S Q1d a bond Me a bond NH S a bond Q3c OH 1519 CH S Q1d a bondMe a bond NH O NH Q3a OH 1520 CH S Q1d a bond Me a bond NH O NH Q3b OH1521 CH S Q1d a bond Me a bond NH O NH Q3c OH 1522 CH S Q1d a bond Me abond NH O a bond Q3a OH 1523 CH S Q1d a bond Me a bond NH O a bond Q3bOH 1524 CH S Q1d a bond Me a bond NH O a bond Q3c OH 1525 CH S Q1d abond H a bond NH S NH Q3a OH 1526 CH S Q1d a bond H a bond NH S NH Q3bOH 1527 CH S Q1d a bond H a bond NH S NH Q3c OH 1528 CH S Q1d a bond H abond NH S a bond Q3a OH 1529 CH S Q1d a bond H a bond NH S a bond Q3b OH1530 CH S Q1d a bond H a bond NH S a bond Q3c OH 1531 CH S Q1d a bond Ha bond NH O NH Q3a OH 1532 CH S Q1d a bond H a bond NH O NH Q3b OH 1533CH S Q1d a bond H a bond NH O NH Q3c OH 1534 CH S Q1d a bond H a bond NHO a bond Q3a OH 1535 CH S Q1d a bond H a bond NH O a bond Q3b OH 1536 CHS Q1d a bond H a bond NH O a bond Q3c OH 1537 CH S Q1e a bond Me a bondNH S NH Q3a OH 1538 CH S Q1e a bond Me a bond NH S NH Q3b OH 1539 CH SQ1e a bond Me a bond NH S NH Q3c OH 1540 CH S Q1e a bond Me a bond NH Sa bond Q3a OH 1541 CH S Q1e a bond Me a bond NH S a bond Q3b OH 1542 CHS Q1e a bond Me a bond NH S a bond Q3c OH 1543 CH S Q1e a bond Me a bondNH O NH Q3a OH 1544 CH S Q1e a bond Me a bond NH O NH Q3b OH 1545 CH SQ1e a bond Me a bond NH O NH Q3c OH 1546 CH S Q1e a bond Me a bond NH Oa bond Q3a OH 1547 CH S Q1e a bond Me a bond NH O a bond Q3b OH 1548 CHS Q1e a bond Me a bond NH O a bond Q3c OH 1549 CH S Q1e a bond H a bondNH S NH Q3a OH 1550 CH S Q1e a bond H a bond NH S NH Q3b OH 1551 CH SQ1e a bond H a bond NH S NH Q3c OH 1552 CH S Q1e a bond H a bond NH S abond Q3a OH 1553 CH S Q1e a bond H a bond NH S a bond Q3b OH 1554 CH SQ1e a bond H a bond NH S a bond Q3c OH 1555 CH S Q1e a bond H a bond NHO NH Q3a OH 1556 CH S Q1e a bond H a bond NH O NH Q3b OH 1557 CH S Q1e abond H a bond NH O NH Q3c OH 1558 CH S Q1e a bond H a bond NH O a bondQ3a OH 1559 CH S Q1e a bond H a bond NH O a bond Q3b OH 1560 CH S Q1e abond H a bond NH O a bond Q3c OH 1561 CH S Q1f a bond Me a bond NH S NHQ3a OH 1562 CH S Q1f a bond Me a bond NH S NH Q3b OH 1563 CH S Q1f abond Me a bond NH S NH Q3c OH 1564 CH S Q1f a bond Me a bond NH S a bondQ3a OH 1565 CH S Q1f a bond Me a bond NH S a bond Q3b OH 1566 CH S Q1f abond Me a bond NH S a bond Q3c OH 1567 CH S Q1f a bond Me a bond NH O NHQ3a OH 1568 CH S Q1f a bond Me a bond NH O NH Q3b OH 1569 CH S Q1f abond Me a bond NH O NH Q3c OH 1570 CH S Q1f a bond Me a bond NH O a bondQ3a OH 1571 CH S Q1f a bond Me a bond NH O a bond Q3b OH 1572 CH S Q1f abond Me a bond NH O a bond Q3c OH 1573 CH S Q1f a bond H a bond NH S NHQ3a OH 1574 CH S Q1f a bond H a bond NH S NH Q3b OH 1575 CH S Q1f a bondH a bond NH S NH Q3c OH 1576 CH S Q1f a bond H a bond NH S a bond Q3a OH1577 CH S Q1f a bond H a bond NH S a bond Q3b OH 1578 CH S Q1f a bond Ha bond NH S a bond Q3c OH 1579 CH S Q1f a bond H a bond NH O NH Q3a OH1580 CH S Q1f a bond H a bond NH O NH Q3b OH 1581 CH S Q1f a bond H abond NH O NH Q3c OH 1582 CH S Q1f a bond H a bond NH O a bond Q3a OH1583 CH S Q1f a bond H a bond NH O a bond Q3b OH 1584 CH S Q1f a bond Ha bond NH O a bond Q3c OH 1585 CH S Q1g a bond Me a bond NH S NH Q3a OH1586 CH S Q1g a bond Me a bond NH S NH Q3b OH 1587 CH S Q1g a bond Me abond NH S NH Q3c OH 1588 CH S Q1g a bond Me a bond NH S a bond Q3a OH1589 CH S Q1g a bond Me a bond NH S a bond Q3b OH 1590 CH S Q1g a bondMe a bond NH S a bond Q3c OH 1591 CH S Q1g a bond Me a bond NH O NH Q3aOH 1592 CH S Q1g a bond Me a bond NH O NH Q3b OH 1593 CH S Q1g a bond Mea bond NH O NH Q3c OH 1594 CH S Q1g a bond Me a bond NH O a bond Q3a OH1595 CH S Q1g a bond Me a bond NH O a bond Q3b OH 1596 CH S Q1g a bondMe a bond NH O a bond Q3c OH 1597 CH S Q1g a bond H a bond NH S NH Q3aOH 1598 CH S Q1g a bond H a bond NH S NH Q3b OH 1599 CH S Q1g a bond H abond NH S NH Q3c OH 1600 CH S Q1g a bond H a bond NH S a bond Q3a OH1601 CH S Q1g a bond H a bond NH S a bond Q3b OH 1602 CH S Q1g a bond Ha bond NH S a bond Q3c OH 1603 CH S Q1g a bond H a bond NH O NH Q3a OH1604 CH S Q1g a bond H a bond NH O NH Q3b OH 1605 CH S Q1g a bond H abond NH O NH Q3c OH 1606 CH S Q1g a bond H a bond NH O a bond Q3a OH1607 CH S Q1g a bond H a bond NH O a bond Q3b OH 1608 CH S Q1g a bond Ha bond NH O a bond Q3c OH 1609 CH S Q1h a bond Me a bond NH S NH Q3a OH1610 CH S Q1h a bond Me a bond NH S NH Q3b OH 1611 CH S Q1h a bond Me abond NH S NH Q3c OH 1612 CH S Q1h a bond Me a bond NH S a bond Q3a OH1613 CH S Q1h a bond Me a bond NH S a bond Q3b OH 1614 CH S Q1h a bondMe a bond NH S a bond Q3c OH 1615 CH S Q1h a bond Me a bond NH O NH Q3aOH 1616 CH S Q1h a bond Me a bond NH O NH Q3b OH 1617 CH S Q1h a bond Mea bond NH O NH Q3c OH 1618 CH S Q1h a bond Me a bond NH O a bond Q3a OH1619 CH S Q1h a bond Me a bond NH O a bond Q3b OH 1620 CH S Q1h a bondMe a bond NH O a bond Q3c OH 1621 CH S Q1h a bond H a bond NH S NH Q3aOH 1622 CH S Q1h a bond H a bond NH S NH Q3b OH 1623 CH S Q1h a bond H abond NH S NH Q3c OH 1624 CH S Q1h a bond H a bond NH S a bond Q3a OH1625 CH S Q1h a bond H a bond NH S a bond Q3b OH 1626 CH S Q1h a bond Ha bond NH S a bond Q3c OH 1627 CH S Q1h a bond H a bond NH O NH Q3a OH1628 CH S Q1h a bond H a bond NH O NH Q3b OH 1629 CH S Q1h a bond H abond NH O NH Q3c OH 1630 CH S Q1h a bond H a bond NH O a bond Q3a OH1631 CH S Q1h a bond H a bond NH O a bond Q3b OH 1632 CH S Q1h a bond Ha bond NH O a bond Q3c OH 1633 CH S Q1i a bond Me a bond NH S NH Q3a OH1634 CH S Q1i a bond Me a bond NH S NH Q3b OH 1635 CH S Q1i a bond Me abond NH S NH Q3c OH 1636 CH S Q1i a bond Me a bond NH S a bond Q3a OH1637 CH S Q1i a bond Me a bond NH S a bond Q3b OH 1638 CH S Q1i a bondMe a bond NH S a bond Q3c OH 1639 CH S Q1i a bond Me a bond NH O NH Q3aOH 1640 CH S Q1i a bond Me a bond NH O NH Q3b OH 1641 CH S Q1i a bond Mea bond NH O NH Q3c OH 1642 CH S Q1i a bond Me a bond NH O a bond Q3a OH1643 CH S Q1i a bond Me a bond NH O a bond Q3b OH 1644 CH S Q1i a bondMe a bond NH O a bond Q3c OH 1645 CH S Q1i a bond H a bond NH S NH Q3aOH 1646 CH S Q1i a bond H a bond NH S NH Q3b OH 1647 CH S Q1i a bond H abond NH S NH Q3c OH 1648 CH S Q1i a bond H a bond NH S a bond Q3a OH1649 CH S Q1i a bond H a bond NH S a bond Q3b OH 1650 CH S Q1i a bond Ha bond NH S a bond Q3c OH 1651 CH S Q1i a bond H a bond NH O NH Q3a OH1652 CH S Q1i a bond H a bond NH O NH Q3b OH 1653 CH S Q1i a bond H abond NH O NH Q3c OH 1654 CH S Q1i a bond H a bond NH O a bond Q3a OH1655 CH S Q1i a bond H a bond NH O a bond Q3b OH 1656 CH S Q1i a bond Ha bond NH O a bond Q3c OH 1657 CH S Q1j a bond Me a bond NH S NH Q3a OH1658 CH S Q1j a bond Me a bond NH S NH Q3b OH 1659 CH S Q1j a bond Me abond NH S NH Q3c OH 1660 CH S Q1j a bond Me a bond NH S a bond Q3a OH1661 CH S Q1j a bond Me a bond NH S a bond Q3b OH 1662 CH S Q1j a bondMe a bond NH S a bond Q3c OH 1663 CH S Q1j a bond Me a bond NH O NH Q3aOH 1664 CH S Q1j a bond Me a bond NH O NH Q3b OH 1665 CH S Q1j a bond Mea bond NH O NH Q3c OH 1666 CH S Q1j a bond Me a bond NH O a bond Q3a OH1667 CH S Q1j a bond Me a bond NH O a bond Q3b OH 1668 CH S Q1j a bondMe a bond NH O a bond Q3c OH 1669 CH S Q1j a bond H a bond NH S NH Q3aOH 1670 CH S Q1j a bond H a bond NH S NH Q3b OH 1671 CH S Q1j a bond H abond NH S NH Q3c OH 1672 CH S Q1j a bond H a bond NH S a bond Q3a OH1673 CH S Q1j a bond H a bond NH S a bond Q3b OH 1674 CH S Q1j a bond Ha bond NH S a bond Q3c OH 1675 CH S Q1j a bond H a bond NH O NH Q3a OH1676 CH S Q1j a bond H a bond NH O NH Q3b OH 1677 CH S Q1j a bond H abond NH O NH Q3c OH 1678 CH S Q1j a bond H a bond NH O a bond Q3a OH1679 CH S Q1j a bond H a bond NH O a bond Q3b OH 1680 CH S Q1j a bond Ha bond NH O a bond Q3c OH 1681 CH O Q1a a bond Me a bond NH S NH Q3a OH1682 CH O Q1a a bond Me a bond NH S NH Q3b OH 1683 CH O Q1a a bond Me abond NH S NH Q3c OH 1684 CH O Q1a a bond Me a bond NH S a bond Q3a OH1685 CH O Q1a a bond Me a bond NH S a bond Q3b OH 1686 CH O Q1a a bondMe a bond NH S a bond Q3c OH 1687 CH O Q1a a bond Me a bond NH O NH Q3aOH 1688 CH O Q1a a bond Me a bond NH O NH Q3b OH 1689 CH O Q1a a bond Mea bond NH O NH Q3c OH 1690 CH O Q1a a bond Me a bond NH O a bond Q3a OH1691 CH O Q1a a bond Me a bond NH O a bond Q3b OH 1692 CH O Q1a a bondMe a bond NH O a bond Q3c OH 1693 CH O Q1a a bond H a bond NH S NH Q3aOH 1694 CH O Q1a a bond H a bond NH S NH Q3b OH 1695 CH O Q1a a bond H abond NH S NH Q3c OH 1696 CH O Q1a a bond H a bond NH S a bond Q3a OH1697 CH O Q1a a bond H a bond NH S a bond Q3b OH 1698 CH O Q1a a bond Ha bond NH S a bond Q3c OH 1699 CH O Q1a a bond H a bond NH O NH Q3a OH1700 CH O Q1a a bond H a bond NH O NH Q3b OH 1701 CH O Q1a a bond H abond NH O NH Q3c OH 1702 CH O Q1a a bond H a bond NH O a bond Q3a OH1703 CH O Q1a a bond H a bond NH O a bond Q3b OH 1704 CH O Q1a a bond Ha bond NH O a bond Q3c OH 1705 CH O Q1b a bond Me a bond NH S NH Q3a OH1706 CH O Q1b a bond Me a bond NH S NH Q3b OH 1707 CH O Q1b a bond Me abond NH S NH Q3c OH 1708 CH O Q1b a bond Me a bond NH S a bond Q3a OH1709 CH O Q1b a bond Me a bond NH S a bond Q3b OH 1710 CH O Q1b a bondMe a bond NH S a bond Q3c OH 1711 CH O Q1b a bond Me a bond NH O NH Q3aOH 1712 CH O Q1b a bond Me a bond NH O NH Q3b OH 1713 CH O Q1b a bond Mea bond NH O NH Q3c OH 1714 CH O Q1b a bond Me a bond NH O a bond Q3a OH1715 CH O Q1b a bond Me a bond NH O a bond Q3b OH 1716 CH O Q1b a bondMe a bond NH O a bond Q3c OH 1717 CH O Q1b a bond H a bond NH S NH Q3aOH 1718 CH O Q1b a bond H a bond NH S NH Q3b OH 1719 CH O Q1b a bond H abond NH S NH Q3c OH 1720 CH O Q1b a bond H a bond NH S a bond Q3a OH1721 CH O Q1b a bond H a bond NH S a bond Q3b OH 1722 CH O Q1b a bond Ha bond NH S a bond Q3c OH 1723 CH O Q1b a bond H a bond NH O NH Q3a OH1724 CH O Q1b a bond H a bond NH O NH Q3b OH 1725 CH O Q1b a bond H abond NH O NH Q3c OH 1726 CH O Q1b a bond H a bond NH O a bond Q3a OH1727 CH O Q1b a bond H a bond NH O a bond Q3b OH 1728 CH O Q1b a bond Ha bond NH O a bond Q3c OH 1729 CH O Q1c a bond Me a bond NH S NH Q3a OH1730 CH O Q1c a bond Me a bond NH S NH Q3b OH 1731 CH O Q1c a bond Me abond NH S NH Q3c OH 1732 CH O Q1c a bond Me a bond NH S a bond Q3a OH1733 CH O Q1c a bond Me a bond NH S a bond Q3b OH 1734 CH O Q1c a bondMe a bond NH S a bond Q3c OH 1735 CH O Q1c a bond Me a bond NH O NH Q3aOH 1736 CH O Q1c a bond Me a bond NH O NH Q3b OH 1737 CH O Q1c a bond Mea bond NH O NH Q3c OH 1738 CH O Q1c a bond Me a bond NH O a bond Q3a OH1739 CH O Q1c a bond Me a bond NH O a bond Q3b OH 1740 CH O Q1c a bondMe a bond NH O a bond Q3c OH 1741 CH O Q1c a bond H a bond NH S NH Q3aOH 1742 CH O Q1c a bond H a bond NH S NH Q3b OH 1743 CH O Q1c a bond H abond NH S NH Q3c OH 1744 CH O Q1c a bond H a bond NH S a bond Q3a OH1745 CH O Q1c a bond H a bond NH S a bond Q3b OH 1746 CH O Q1c a bond Ha bond NH S a bond Q3c OH 1747 CH O Q1c a bond H a bond NH O NH Q3a OH1748 CH O Q1c a bond H a bond NH O NH Q3b OH 1749 CH O Q1c a bond H abond NH O NH Q3c OH 1750 CH O Q1c a bond H a bond NH O a bond Q3a OH1751 CH O Q1c a bond H a bond NH O a bond Q3b OH 1752 CH O Q1c a bond Ha bond NH O a bond Q3c OH 1753 CH O Q1d a bond Me a bond NH S NH Q3a OH1754 CH O Q1d a bond Me a bond NH S NH Q3b OH 1755 CH O Q1d a bond Me abond NH S NH Q3c OH 1756 CH O Q1d a bond Me a bond NH S a bond Q3a OH1757 CH O Q1d a bond Me a bond NH S a bond Q3b OH 1758 CH O Q1d a bondMe a bond NH S a bond Q3c OH 1759 CH O Q1d a bond Me a bond NH O NH Q3aOH 1760 CH O Q1d a bond Me a bond NH O NH Q3b OH 1761 CH O Q1d a bond Mea bond NH O NH Q3c OH 1762 CH O Q1d a bond Me a bond NH O a bond Q3a OH1763 CH O Q1d a bond Me a bond NH O a bond Q3b OH 1764 CH O Q1d a bondMe a bond NH O a bond Q3c OH 1765 CH O Q1d a bond H a bond NH S NH Q3aOH 1766 CH O Q1d a bond H a bond NH S NH Q3b OH 1767 CH O Q1d a bond H abond NH S NH Q3c OH 1768 CH O Q1d a bond H a bond NH S a bond Q3a OH1769 CH O Q1d a bond H a bond NH S a bond Q3b OH 1770 CH O Q1d a bond Ha bond NH S a bond Q3c OH 1771 CH O Q1d a bond H a bond NH O NH Q3a OH1772 CH O Q1d a bond H a bond NH O NH Q3b OH 1773 CH O Q1d a bond H abond NH O NH Q3c OH 1774 CH O Q1d a bond H a bond NH O a bond Q3a OH1775 CH O Q1d a bond H a bond NH O a bond Q3b OH 1776 CH O Q1d a bond Ha bond NH O a bond Q3c OH 1777 CH O Q1e a bond Me a bond NH S NH Q3a OH1778 CH O Q1e a bond Me a bond NH S NH Q3b OH 1779 CH O Q1e a bond Me abond NH S NH Q3c OH 1780 CH O Q1e a bond Me a bond NH S a bond Q3a OH1781 CH O Q1e a bond Me a bond NH S a bond Q3b OH 1782 CH O Q1e a bondMe a bond NH S a bond Q3c OH 1783 CH O Q1e a bond Me a bond NH O NH Q3aOH 1784 CH O Q1e a bond Me a bond NH O NH Q3b OH 1785 CH O Q1e a bond Mea bond NH O NH Q3c OH 1786 CH O Q1e a bond Me a bond NH O a bond Q3a OH1787 CH O Q1e a bond Me a bond NH O a bond Q3b OH 1788 CH O Q1e a bondMe a bond NH O a bond Q3c OH 1789 CH O Q1e a bond H a bond NH S NH Q3aOH 1790 CH O Q1e a bond H a bond NH S NH Q3b OH 1791 CH O Q1e a bond H abond NH S NH Q3c OH 1792 CH O Q1e a bond H a bond NH S a bond Q3a OH1793 CH O Q1e a bond H a bond NH S a bond Q3b OH 1794 CH O Q1e a bond Ha bond NH S a bond Q3c OH 1795 CH O Q1e a bond H a bond NH O NH Q3a OH1796 CH O Q1e a bond H a bond NH O NH Q3b OH 1797 CH O Q1e a bond H abond NH O NH Q3c OH 1798 CH O Q1e a bond H a bond NH O a bond Q3a OH1799 CH O Q1e a bond H a bond NH O a bond Q3b OH 1800 CH O Q1e a bond Ha bond NH O a bond Q3c OH 1801 CH O Q1f a bond Me a bond NH S NH Q3a OH1802 CH O Q1f a bond Me a bond NH S NH Q3b OH 1803 CH O Q1f a bond Me abond NH S NH Q3c OH 1804 CH O Q1f a bond Me a bond NH S a bond Q3a OH1805 CH O Q1f a bond Me a bond NH S a bond Q3b OH 1806 CH O Q1f a bondMe a bond NH S a bond Q3c OH 1807 CH O Q1f a bond Me a bond NH O NH Q3aOH 1808 CH O Q1f a bond Me a bond NH O NH Q3b OH 1809 CH O Q1f a bond Mea bond NH O NH Q3c OH 1810 CH O Q1f a bond Me a bond NH O a bond Q3a OH1811 CH O Q1f a bond Me a bond NH O a bond Q3b OH 1812 CH O Q1f a bondMe a bond NH O a bond Q3c OH 1813 CH O Q1f a bond H a bond NH S NH Q3aOH 1814 CH O Q1f a bond H a bond NH S NH Q3b OH 1815 CH O Q1f a bond H abond NH S NH Q3c OH 1816 CH O Q1f a bond H a bond NH S a bond Q3a OH1817 CH O Q1f a bond H a bond NH S a bond Q3b OH 1818 CH O Q1f a bond Ha bond NH S a bond Q3c OH 1819 CH O Q1f a bond H a bond NH O NH Q3a OH1820 CH O Q1f a bond H a bond NH O NH Q3b OH 1821 CH O Q1f a bond H abond NH O NH Q3c OH 1822 CH O Q1f a bond H a bond NH O a bond Q3a OH1823 CH O Q1f a bond H a bond NH O a bond Q3b OH 1824 CH O Q1f a bond Ha bond NH O a bond Q3c OH 1825 CH O Q1g a bond Me a bond NH S NH Q3a OH1826 CH O Q1g a bond Me a bond NH S NH Q3b OH 1827 CH O Q1g a bond Me abond NH S NH Q3c OH 1828 CH O Q1g a bond Me a bond NH S a bond Q3a OH1829 CH O Q1g a bond Me a bond NH S a bond Q3b OH 1830 CH O Q1g a bondMe a bond NH S a bond Q3c OH 1831 CH O Q1g a bond Me a bond NH O NH Q3aOH 1832 CH O Q1g a bond Me a bond NH O NH Q3b OH 1833 CH O Q1g a bond Mea bond NH O NH Q3c OH 1834 CH O Q1g a bond Me a bond NH O a bond Q3a OH1835 CH O Q1g a bond Me a bond NH O a bond Q3b OH 1836 CH O Q1g a bondMe a bond NH O a bond Q3c OH 1837 CH O Q1g a bond H a bond NH S NH Q3aOH 1838 CH O Q1g a bond H a bond NH S NH Q3b OH 1839 CH O Q1g a bond H abond NH S NH Q3c OH 1840 CH O Q1g a bond H a bond NH S a bond Q3a OH1841 CH O Q1g a bond H a bond NH S a bond Q3b OH 1842 CH O Q1g a bond Ha bond NH S a bond Q3c OH 1843 CH O Q1g a bond H a bond NH O NH Q3a OH1844 CH O Q1g a bond H a bond NH O NH Q3b OH 1845 CH O Q1g a bond H abond NH O NH Q3c OH 1846 CH O Q1g a bond H a bond NH O a bond Q3a OH1847 CH O Q1g a bond H a bond NH O a bond Q3b OH 1848 CH O Q1g a bond Ha bond NH O a bond Q3c OH 1849 CH O Q1h a bond Me a bond NH S NH Q3a OH1850 CH O Q1h a bond Me a bond NH S NH Q3b OH 1851 CH O Q1h a bond Me abond NH S NH Q3c OH 1852 CH O Q1h a bond Me a bond NH S a bond Q3a OH1853 CH O Q1h a bond Me a bond NH S a bond Q3b OH 1854 CH O Q1h a bondMe a bond NH S a bond Q3c OH 1855 CH O Q1h a bond Me a bond NH O NH Q3aOH 1856 CH O Q1h a bond Me a bond NH O NH Q3b OH 1857 CH O Q1h a bond Mea bond NH O NH Q3c OH 1858 CH O Q1h a bond Me a bond NH O a bond Q3a OH1859 CH O Q1h a bond Me a bond NH O a bond Q3b OH 1860 CH O Q1h a bondMe a bond NH O a bond Q3c OH 1861 CH O Q1h a bond H a bond NH S NH Q3aOH 1862 CH O Q1h a bond H a bond NH S NH Q3b OH 1863 CH O Q1h a bond H abond NH S NH Q3c OH 1864 CH O Q1h a bond H a bond NH S a bond Q3a OH1865 CH O Q1h a bond H a bond NH S a bond Q3b OH 1866 CH O Q1h a bond Ha bond NH S a bond Q3c OH 1867 CH O Q1h a bond H a bond NH O NH Q3a OH1868 CH O Q1h a bond H a bond NH O NH Q3b OH 1869 CH O Q1h a bond H abond NH O NH Q3c OH 1870 CH O Q1h a bond H a bond NH O a bond Q3a OH1871 CH O Q1h a bond H a bond NH O a bond Q3b OH 1872 CH O Q1h a bond Ha bond NH O a bond Q3c OH 1873 CH O Q1i a bond Me a bond NH S NH Q3a OH1874 CH O Q1i a bond Me a bond NH S NH Q3b OH 1875 CH O Q1i a bond Me abond NH S NH Q3c OH 1876 CH O Q1i a bond Me a bond NH S a bond Q3a OH1877 CH O Q1i a bond Me a bond NH S a bond Q3b OH 1878 CH O Q1i a bondMe a bond NH S a bond Q3c OH 1879 CH O Q1i a bond Me a bond NH O NH Q3aOH 1880 CH O Q1i a bond Me a bond NH O NH Q3b OH 1881 CH O Q1i a bond Mea bond NH O NH Q3c OH 1882 CH O Q1i a bond Me a bond NH O a bond Q3a OH1883 CH O Q1i a bond Me a bond NH O a bond Q3b OH 1884 CH O Q1i a bondMe a bond NH O a bond Q3c OH 1885 CH O Q1i a bond H a bond NH S NH Q3aOH 1886 CH O Q1i a bond H a bond NH S NH Q3b OH 1887 CH O Q1i a bond H abond NH S NH Q3c OH 1888 CH O Q1i a bond H a bond NH S a bond Q3a OH1889 CH O Q1i a bond H a bond NH S a bond Q3b OH 1890 CH O Q1i a bond Ha bond NH S a bond Q3c OH 1891 CH O Q1i a bond H a bond NH O NH Q3a OH1892 CH O Q1i a bond H a bond NH O NH Q3b OH 1893 CH O Q1i a bond H abond NH O NH Q3c OH 1894 CH O Q1i a bond H a bond NH O a bond Q3a OH1895 CH O Q1i a bond H a bond NH O a bond Q3b OH 1896 CH O Q1i a bond Ha bond NH O a bond Q3c OH 1897 CH O Q1j a bond Me a bond NH S NH Q3a OH1898 CH O Q1j a bond Me a bond NH S NH Q3b OH 1899 CH O Q1j a bond Me abond NH S NH Q3c OH 1900 CH O Q1j a bond Me a bond NH S a bond Q3a OH1901 CH O Q1j a bond Me a bond NH S a bond Q3b OH 1902 CH O Q1j a bondMe a bond NH S a bond Q3c OH 1903 CH O Q1j a bond Me a bond NH O NH Q3aOH 1904 CH O Q1j a bond Me a bond NH O NH Q3b OH 1905 CH O Q1j a bond Mea bond NH O NH Q3c OH 1906 CH O Q1j a bond Me a bond NH O a bond Q3a OH1907 CH O Q1j a bond Me a bond NH O a bond Q3b OH 1908 CH O Q1j a bondMe a bond NH O a bond Q3c OH 1909 CH O Q1j a bond H a bond NH S NH Q3aOH 1910 CH O Q1j a bond H a bond NH S NH Q3b OH 1911 CH O Q1j a bond H abond NH S NH Q3c OH 1912 CH O Q1j a bond H a bond NH S a bond Q3a OH1913 CH O Q1j a bond H a bond NH S a bond Q3b OH 1914 CH O Q1j a bond Ha bond NH S a bond Q3c OH 1915 CH O Q1j a bond H a bond NH O NH Q3a OH1916 CH O Q1j a bond H a bond NH O NH Q3b OH 1917 CH O Q1j a bond H abond NH O NH Q3c OH 1918 CH O Q1j a bond H a bond NH O a bond Q3a OH1919 CH O Q1j a bond H a bond NH O a bond Q3b OH 1920 CH O Q1j a bond Ha bond NH O a bond Q3c OH 1921 CMe NMe Q1a a bond Me a bond NH S NH Q3aOH 1922 CMe NMe Q1a a bond Me a bond NH S NH Q3b OH 1923 CMe NMe Q1a abond Me a bond NH S NH Q3c OH 1924 CMe NMe Q1a a bond Me a bond NH S abond Q3a OH 1925 CMe NMe Q1a a bond Me a bond NH S a bond Q3b OH 1926CMe NMe Q1a a bond Me a bond NH S a bond Q3c OH 1927 CMe NMe Q1a a bondMe a bond NH O NH Q3a OH 1928 CMe NMe Q1a a bond Me a bond NH O NH Q3bOH 1929 CMe NMe Q1a a bond Me a bond NH O NH Q3c OH 1930 CMe NMe Q1a abond Me a bond NH O a bond Q3a OH 1931 CMe NMe Q1a a bond Me a bond NH Oa bond Q3b OH 1932 CMe NMe Q1a a bond Me a bond NH O a bond Q3c OH 1933CMe NMe Q1a a bond H a bond NH S NH Q3a OH 1934 CMe NMe Q1a a bond H abond NH S NH Q3b OH 1935 CMe NMe Q1a a bond H a bond NH S NH Q3c OH 1936CMe NMe Q1a a bond H a bond NH S a bond Q3a OH 1937 CMe NMe Q1a a bond Ha bond NH S a bond Q3b OH 1938 CMe NMe Q1a a bond H a bond NH S a bondQ3c OH 1939 CMe NMe Q1a a bond H a bond NH O NH Q3a OH 1940 CMe NMe Q1aa bond H a bond NH O NH Q3b OH 1941 CMe NMe Q1a a bond H a bond NH O NHQ3c OH 1942 CMe NMe Q1a a bond H a bond NH O a bond Q3a OH 1943 CMe NMeQ1a a bond H a bond NH O a bond Q3b OH 1944 CMe NMe Q1a a bond H a bondNH O a bond Q3c OH 1945 CMe NMe Q1b a bond Me a bond NH S NH Q3a OH 1946CMe NMe Q1b a bond Me a bond NH S NH Q3b OH 1947 CMe NMe Q1b a bond Me abond NH S NH Q3c OH 1948 CMe NMe Q1b a bond Me a bond NH S a bond Q3a OH1949 CMe NMe Q1b a bond Me a bond NH S a bond Q3b OH 1950 CMe NMe Q1b abond Me a bond NH S a bond Q3c OH 1951 CMe NMe Q1b a bond Me a bond NH ONH Q3a OH 1952 CMe NMe Q1b a bond Me a bond NH O NH Q3b OH 1953 CMe NMeQ1b a bond Me a bond NH O NH Q3c OH 1954 CMe NMe Q1b a bond Me a bond NHO a bond Q3a OH 1955 CMe NMe Q1b a bond Me a bond NH O a bond Q3b OH1956 CMe NMe Q1b a bond Me a bond NH O a bond Q3c OH 1957 CMe NMe Q1b abond H a bond NH S NH Q3a OH 1958 CMe NMe Q1b a bond H a bond NH S NHQ3b OH 1959 CMe NMe Q1b a bond H a bond NH S NH Q3c OH 1960 CMe NMe Q1ba bond H a bond NH S a bond Q3a OH 1961 CMe NMe Q1b a bond H a bond NH Sa bond Q3b OH 1962 CMe NMe Q1b a bond H a bond NH S a bond Q3c OH 1963CMe NMe Q1b a bond H a bond NH O NH Q3a OH 1964 CMe NMe Q1b a bond H abond NH O NH Q3b OH 1965 CMe NMe Q1b a bond H a bond NH O NH Q3c OH 1966CMe NMe Q1b a bond H a bond NH O a bond Q3a OH 1967 CMe NMe Q1b a bond Ha bond NH O a bond Q3b OH 1968 CMe NMe Q1b a bond H a bond NH O a bondQ3c OH 1969 CMe NMe Q1c a bond Me a bond NH S NH Q3a OH 1970 CMe NMe Q1ca bond Me a bond NH S NH Q3b OH 1971 CMe NMe Q1c a bond Me a bond NH SNH Q3c OH 1972 CMe NMe Q1c a bond Me a bond NH S a bond Q3a OH 1973 CMeNMe Q1c a bond Me a bond NH S a bond Q3b OH 1974 CMe NMe Q1c a bond Me abond NH S a bond Q3c OH 1975 CMe NMe Q1c a bond Me a bond NH O NH Q3a OH1976 CMe NMe Q1c a bond Me a bond NH O NH Q3b OH 1977 CMe NMe Q1c a bondMe a bond NH O NH Q3c OH 1978 CMe NMe Q1c a bond Me a bond NH O a bondQ3a OH 1979 CMe NMe Q1c a bond Me a bond NH O a bond Q3b OH 1980 CMe NMeQ1c a bond Me a bond NH O a bond Q3c OH 1981 CMe NMe Q1c a bond H a bondNH S NH Q3a OH 1982 CMe NMe Q1c a bond H a bond NH S NH Q3b OH 1983 CMeNMe Q1c a bond H a bond NH S NH Q3c OH 1984 CMe NMe Q1c a bond H a bondNH S a bond Q3a OH 1985 CMe NMe Q1c a bond H a bond NH S a bond Q3b OH1986 CMe NMe Q1c a bond H a bond NH S a bond Q3c OH 1987 CMe NMe Q1c abond H a bond NH O NH Q3a OH 1988 CMe NMe Q1c a bond H a bond NH O NHQ3b OH 1989 CMe NMe Q1c a bond H a bond NH O NH Q3c OH 1990 CMe NMe Q1ca bond H a bond NH O a bond Q3a OH 1991 CMe NMe Q1c a bond H a bond NH Oa bond Q3b OH 1992 CMe NMe Q1c a bond H a bond NH O a bond Q3c OH 1993CMe NMe Q1d a bond Me a bond NH S NH Q3a OH 1994 CMe NMe Q1d a bond Me abond NH S NH Q3b OH 1995 CMe NMe Q1d a bond Me a bond NH S NH Q3c OH1996 CMe NMe Q1d a bond Me a bond NH S a bond Q3a OH 1997 CMe NMe Q1d abond Me a bond NH S a bond Q3b OH 1998 CMe NMe Q1d a bond Me a bond NH Sa bond Q3c OH 1999 CMe NMe Q1d a bond Me a bond NH O NH Q3a OH 2000 CMeNMe Q1d a bond Me a bond NH O NH Q3b OH 2001 CMe NMe Q1d a bond Me abond NH O NH Q3c OH 2002 CMe NMe Q1d a bond Me a bond NH O a bond Q3a OH2003 CMe NMe Q1d a bond Me a bond NH O a bond Q3b OH 2004 CMe NMe Q1d abond Me a bond NH O a bond Q3c OH 2005 CMe NMe Q1d a bond H a bond NH SNH Q3a OH 2006 CMe NMe Q1d a bond H a bond NH S NH Q3b OH 2007 CMe NMeQ1d a bond H a bond NH S NH Q3c OH 2008 CMe NMe Q1d a bond H a bond NH Sa bond Q3a OH 2009 CMe NMe Q1d a bond H a bond NH S a bond Q3b OH 2010CMe NMe Q1d a bond H a bond NH S a bond Q3c OH 2011 CMe NMe Q1d a bond Ha bond NH O NH Q3a OH 2012 CMe NMe Q1d a bond H a bond NH O NH Q3b OH2013 CMe NMe Q1d a bond H a bond NH O NH Q3c OH 2014 CMe NMe Q1d a bondH a bond NH O a bond Q3a OH 2015 CMe NMe Q1d a bond H a bond NH O a bondQ3b OH 2016 CMe NMe Q1d a bond H a bond NH O a bond Q3c OH 2017 CMe NMeQ1e a bond Me a bond NH S NH Q3a OH 2018 CMe NMe Q1e a bond Me a bond NHS NH Q3b OH 2019 CMe NMe Q1e a bond Me a bond NH S NH Q3c OH 2020 CMeNMe Q1e a bond Me a bond NH S a bond Q3a OH 2021 CMe NMe Q1e a bond Me abond NH S a bond Q3b OH 2022 CMe NMe Q1e a bond Me a bond NH S a bondQ3c OH 2023 CMe NMe Q1e a bond Me a bond NH O NH Q3a OH 2024 CMe NMe Q1ea bond Me a bond NH O NH Q3b OH 2025 CMe NMe Q1e a bond Me a bond NH ONH Q3c OH 2026 CMe NMe Q1e a bond Me a bond NH O a bond Q3a OH 2027 CMeNMe Q1e a bond Me a bond NH O a bond Q3b OH 2028 CMe NMe Q1e a bond Me abond NH O a bond Q3c OH 2029 CMe NMe Q1e a bond H a bond NH S NH Q3a OH2030 CMe NMe Q1e a bond H a bond NH S NH Q3b OH 2031 CMe NMe Q1e a bondH a bond NH S NH Q3c OH 2032 CMe NMe Q1e a bond H a bond NH S a bond Q3aOH 2033 CMe NMe Q1e a bond H a bond NH S a bond Q3b OH 2034 CMe NMe Q1ea bond H a bond NH S a bond Q3c OH 2035 CMe NMe Q1e a bond H a bond NH ONH Q3a OH 2036 CMe NMe Q1e a bond H a bond NH O NH Q3b OH 2037 CMe NMeQ1e a bond H a bond NH O NH Q3c OH 2038 CMe NMe Q1e a bond H a bond NH Oa bond Q3a OH 2039 CMe NMe Q1e a bond H a bond NH O a bond Q3b OH 2040CMe NMe Q1e a bond H a bond NH O a bond Q3c OH 2041 CMe NMe Q1f a bondMe a bond NH S NH Q3a OH 2042 CMe NMe Q1f a bond Me a bond NH S NH Q3bOH 2043 CMe NMe Q1f a bond Me a bond NH S NH Q3c OH 2044 CMe NMe Q1f abond Me a bond NH S a bond Q3a OH 2045 CMe NMe Q1f a bond Me a bond NH Sa bond Q3b OH 2046 CMe NMe Q1f a bond Me a bond NH S a bond Q3c OH 2047CMe NMe Q1f a bond Me a bond NH O NH Q3a OH 2048 CMe NMe Q1f a bond Me abond NH O NH Q3b OH 2049 CMe NMe Q1f a bond Me a bond NH O NH Q3c OH2050 CMe NMe Q1f a bond Me a bond NH O a bond Q3a OH 2051 CMe NMe Q1f abond Me a bond NH O a bond Q3b OH 2052 CMe NMe Q1f a bond Me a bond NH Oa bond Q3c OH 2053 CMe NMe Q1f a bond H a bond NH S NH Q3a OH 2054 CMeNMe Q1f a bond H a bond NH S NH Q3b OH 2055 CMe NMe Q1f a bond H a bondNH S NH Q3c OH 2056 CMe NMe Q1f a bond H a bond NH S a bond Q3a OH 2057CMe NMe Q1f a bond H a bond NH S a bond Q3b OH 2058 CMe NMe Q1f a bond Ha bond NH S a bond Q3c OH 2059 CMe NMe Q1f a bond H a bond NH O NH Q3aOH 2060 CMe NMe Q1f a bond H a bond NH O NH Q3b OH 2061 CMe NMe Q1f abond H a bond NH O NH Q3c OH 2062 CMe NMe Q1f a bond H a bond NH O abond Q3a OH 2063 CMe NMe Q1f a bond H a bond NH O a bond Q3b OH 2064 CMeNMe Q1f a bond H a bond NH O a bond Q3c OH 2065 CMe NMe Q1g a bond Me abond NH S NH Q3a OH 2066 CMe NMe Q1g a bond Me a bond NH S NH Q3b OH2067 CMe NMe Q1g a bond Me a bond NH S NH Q3c OH 2068 CMe NMe Q1g a bondMe a bond NH S a bond Q3a OH 2069 CMe NMe Q1g a bond Me a bond NH S abond Q3b OH 2070 CMe NMe Q1g a bond Me a bond NH S a bond Q3c OH 2071CMe NMe Q1g a bond Me a bond NH O NH Q3a OH 2072 CMe NMe Q1g a bond Me abond NH O NH Q3b OH 2073 CMe NMe Q1g a bond Me a bond NH O NH Q3c OH2074 CMe NMe Q1g a bond Me a bond NH O a bond Q3a OH 2075 CMe NMe Q1g abond Me a bond NH O a bond Q3b OH 2076 CMe NMe Q1g a bond Me a bond NH Oa bond Q3c OH 2077 CMe NMe Q1g a bond H a bond NH S NH Q3a OH 2078 CMeNMe Q1g a bond H a bond NH S NH Q3b OH 2079 CMe NMe Q1g a bond H a bondNH S NH Q3c OH 2080 CMe NMe Q1g a bond H a bond NH S a bond Q3a OH 2081CMe NMe Q1g a bond H a bond NH S a bond Q3b OH 2082 CMe NMe Q1g a bond Ha bond NH S a bond Q3c OH 2083 CMe NMe Q1g a bond H a bond NH O NH Q3aOH 2084 CMe NMe Q1g a bond H a bond NH O NH Q3b OH 2085 CMe NMe Q1g abond H a bond NH O NH Q3c OH 2086 CMe NMe Q1g a bond H a bond NH O abond Q3a OH 2087 CMe NMe Q1g a bond H a bond NH O a bond Q3b OH 2088 CMeNMe Q1g a bond H a bond NH O a bond Q3c OH 2089 CMe NMe Q1h a bond Me abond NH S NH Q3a OH 2090 CMe NMe Q1h a bond Me a bond NH S NH Q3b OH2091 CMe NMe Q1h a bond Me a bond NH S NH Q3c OH 2092 CMe NMe Q1h a bondMe a bond NH S a bond Q3a OH 2093 CMe NMe Q1h a bond Me a bond NH S abond Q3b OH 2094 CMe NMe Q1h a bond Me a bond NH S a bond Q3c OH 2095CMe NMe Q1h a bond Me a bond NH O NH Q3a OH 2096 CMe NMe Q1h a bond Me abond NH O NH Q3b OH 2097 CMe NMe Q1h a bond Me a bond NH O NH Q3c OH2098 CMe NMe Q1h a bond Me a bond NH O a bond Q3a OH 2099 CMe NMe Q1h abond Me a bond NH O a bond Q3b OH 2100 CMe NMe Q1h a bond Me a bond NH Oa bond Q3c OH 2101 CMe NMe Q1h a bond H a bond NH S NH Q3a OH 2102 CMeNMe Q1h a bond H a bond NH S NH Q3b OH 2103 CMe NMe Q1h a bond H a bondNH S NH Q3c OH 2104 CMe NMe Q1h a bond H a bond NH S a bond Q3a OH 2105CMe NMe Q1h a bond H a bond NH S a bond Q3b OH 2106 CMe NMe Q1h a bond Ha bond NH S a bond Q3c OH 2107 CMe NMe Q1h a bond H a bond NH O NH Q3aOH 2108 CMe NMe Q1h a bond H a bond NH O NH Q3b OH 2109 CMe NMe Q1h abond H a bond NH O NH Q3c OH 2110 CMe NMe Q1h a bond H a bond NH O abond Q3a OH 2111 CMe NMe Q1h a bond H a bond NH O a bond Q3b OH 2112 CMeNMe Q1h a bond H a bond NH O a bond Q3c OH 2113 CMe NMe Q1i a bond Me abond NH S NH Q3a OH 2114 CMe NMe Q1i a bond Me a bond NH S NH Q3b OH2115 CMe NMe Q1i a bond Me a bond NH S NH Q3c OH 2116 CMe NMe Q1i a bondMe a bond NH S a bond Q3a OH 2117 CMe NMe Q1i a bond Me a bond NH S abond Q3b OH 2118 CMe NMe Q1i a bond Me a bond NH S a bond Q3c OH 2119CMe NMe Q1i a bond Me a bond NH O NH Q3a OH 2120 CMe NMe Q1i a bond Me abond NH O NH Q3b OH 2121 CMe NMe Q1i a bond Me a bond NH O NH Q3c OH2122 CMe NMe Q1i a bond Me a bond NH O a bond Q3a OH 2123 CMe NMe Q1i abond Me a bond NH O a bond Q3b OH 2124 CMe NMe Q1i a bond Me a bond NH Oa bond Q3c OH 2125 CMe NMe Q1i a bond H a bond NH S NH Q3a OH 2126 CMeNMe Q1i a bond H a bond NH S NH Q3b OH 2127 CMe NMe Q1i a bond H a bondNH S NH Q3c OH 2128 CMe NMe Q1i a bond H a bond NH S a bond Q3a OH 2129CMe NMe Q1i a bond H a bond NH S a bond Q3b OH 2130 CMe NMe Q1i a bond Ha bond NH S a bond Q3c OH 2131 CMe NMe Q1i a bond H a bond NH O NH Q3aOH 2132 CMe NMe Q1i a bond H a bond NH O NH Q3b OH 2133 CMe NMe Q1i abond H a bond NH O NH Q3c OH 2134 CMe NMe Q1i a bond H a bond NH O abond Q3a OH 2135 CMe NMe Q1i a bond H a bond NH O a bond Q3b OH 2136 CMeNMe Q1i a bond H a bond NH O a bond Q3c OH 2137 CMe NMe Q1j a bond Me abond NH S NH Q3a OH 2138 CMe NMe Q1j a bond Me a bond NH S NH Q3b OH2139 CMe NMe Q1j a bond Me a bond NH S NH Q3c OH 2140 CMe NMe Q1j a bondMe a bond NH S a bond Q3a OH 2141 CMe NMe Q1j a bond Me a bond NH S abond Q3b OH 2142 CMe NMe Q1j a bond Me a bond NH S a bond Q3c OH 2143CMe NMe Q1j a bond Me a bond NH O NH Q3a OH 2144 CMe NMe Q1j a bond Me abond NH O NH Q3b OH 2145 CMe NMe Q1j a bond Me a bond NH O NH Q3c OH2146 CMe NMe Q1j a bond Me a bond NH O a bond Q3a OH 2147 CMe NMe Q1j abond Me a bond NH O a bond Q3b OH 2148 CMe NMe Q1j a bond Me a bond NH Oa bond Q3c OH 2149 CMe NMe Q1j a bond H a bond NH S NH Q3a OH 2150 CMeNMe Q1j a bond H a bond NH S NH Q3b OH 2151 CMe NMe Q1j a bond H a bondNH S NH Q3c OH 2152 CMe NMe Q1j a bond H a bond NH S a bond Q3a OH 2153CMe NMe Q1j a bond H a bond NH S a bond Q3b OH 2154 CMe NMe Q1j a bond Ha bond NH S a bond Q3c OH 2155 CMe NMe Q1j a bond H a bond NH O NH Q3aOH 2156 CMe NMe Q1j a bond H a bond NH O NH Q3b OH 2157 CMe NMe Q1j abond H a bond NH O NH Q3c OH 2158 CMe NMe Q1j a bond H a bond NH O abond Q3a OH 2159 CMe NMe Q1j a bond H a bond NH O a bond Q3b OH 2160 CMeNMe Q1j a bond H a bond NH O a bond Q3c OH 2161 CMe NEt Q1a a bond Me abond NH S NH Q3a OH 2162 CMe NEt Q1a a bond Me a bond NH S NH Q3b OH2163 CMe NEt Q1a a bond Me a bond NH S NH Q3c OH 2164 CMe NEt Q1a a bondMe a bond NH S a bond Q3a OH 2165 CMe NEt Q1a a bond Me a bond NH S abond Q3b OH 2166 CMe NEt Q1a a bond Me a bond NH S a bond Q3c OH 2167CMe NEt Q1a a bond Me a bond NH O NH Q3a OH 2168 CMe NEt Q1a a bond Me abond NH O NH Q3b OH 2169 CMe NEt Q1a a bond Me a bond NH O NH Q3c OH2170 CMe NEt Q1a a bond Me a bond NH O a bond Q3a OH 2171 CMe NEt Q1a abond Me a bond NH O a bond Q3b OH 2172 CMe NEt Q1a a bond Me a bond NH Oa bond Q3c OH 2173 CMe NEt Q1a a bond H a bond NH S NH Q3a OH 2174 CMeNEt Q1a a bond H a bond NH S NH Q3b OH 2175 CMe NEt Q1a a bond H a bondNH S NH Q3c OH 2176 CMe NEt Q1a a bond H a bond NH S a bond Q3a OH 2177CMe NEt Q1a a bond H a bond NH S a bond Q3b OH 2178 CMe NEt Q1a a bond Ha bond NH S a bond Q3c OH 2179 CMe NEt Q1a a bond H a bond NH O NH Q3aOH 2180 CMe NEt Q1a a bond H a bond NH O NH Q3b OH 2181 CMe NEt Q1a abond H a bond NH O NH Q3c OH 2182 CMe NEt Q1a a bond H a bond NH O abond Q3a OH 2183 CMe NEt Q1a a bond H a bond NH O a bond Q3b OH 2184 CMeNEt Q1a a bond H a bond NH O a bond Q3c OH 2185 CMe NEt Q1b a bond Me abond NH S NH Q3a OH 2186 CMe NEt Q1b a bond Me a bond NH S NH Q3b OH2187 CMe NEt Q1b a bond Me a bond NH S NH Q3c OH 2188 CMe NEt Q1b a bondMe a bond NH S a bond Q3a OH 2189 CMe NEt Q1b a bond Me a bond NH S abond Q3b OH 2190 CMe NEt Q1b a bond Me a bond NH S a bond Q3c OH 2191CMe NEt Q1b a bond Me a bond NH O NH Q3a OH 2192 CMe NEt Q1b a bond Me abond NH O NH Q3b OH 2193 CMe NEt Q1b a bond Me a bond NH O NH Q3c OH2194 CMe NEt Q1b a bond Me a bond NH O a bond Q3a OH 2195 CMe NEt Q1b abond Me a bond NH O a bond Q3b OH 2196 CMe NEt Q1b a bond Me a bond NH Oa bond Q3c OH 2197 CMe NEt Q1b a bond H a bond NH S NH Q3a OH 2198 CMeNEt Q1b a bond H a bond NH S NH Q3b OH 2199 CMe NEt Q1b a bond H a bondNH S NH Q3c OH 2200 CMe NEt Q1b a bond H a bond NH S a bond Q3a OH 2201CMe NEt Q1b a bond H a bond NH S a bond Q3b OH 2202 CMe NEt Q1b a bond Ha bond NH S a bond Q3c OH 2203 CMe NEt Q1b a bond H a bond NH O NH Q3aOH 2204 CMe NEt Q1b a bond H a bond NH O NH Q3b OH 2205 CMe NEt Q1b abond H a bond NH O NH Q3c OH 2206 CMe NEt Q1b a bond H a bond NH O abond Q3a OH 2207 CMe NEt Q1b a bond H a bond NH O a bond Q3b OH 2208 CMeNEt Q1b a bond H a bond NH O a bond Q3c OH 2209 CMe NEt Q1c a bond Me abond NH S NH Q3a OH 2210 CMe NEt Q1c a bond Me a bond NH S NH Q3b OH2211 CMe NEt Q1c a bond Me a bond NH S NH Q3c OH 2212 CMe NEt Q1c a bondMe a bond NH S a bond Q3a OH 2213 CMe NEt Q1c a bond Me a bond NH S abond Q3b OH 2214 CMe NEt Q1c a bond Me a bond NH S a bond Q3c OH 2215CMe NEt Q1c a bond Me a bond NH O NH Q3a OH 2216 CMe NEt Q1c a bond Me abond NH O NH Q3b OH 2217 CMe NEt Q1c a bond Me a bond NH O NH Q3c OH2218 CMe NEt Q1c a bond Me a bond NH O a bond Q3a OH 2219 CMe NEt Q1c abond Me a bond NH O a bond Q3b OH 2220 CMe NEt Q1c a bond Me a bond NH Oa bond Q3c OH 2221 CMe NEt Q1c a bond H a bond NH S NH Q3a OH 2222 CMeNEt Q1c a bond H a bond NH S NH Q3b OH 2223 CMe NEt Q1c a bond H a bondNH S NH Q3c OH 2224 CMe NEt Q1c a bond H a bond NH S a bond Q3a OH 2225CMe NEt Q1c a bond H a bond NH S a bond Q3b OH 2226 CMe NEt Q1c a bond Ha bond NH S a bond Q3c OH 2227 CMe NEt Q1c a bond H a bond NH O NH Q3aOH 2228 CMe NEt Q1c a bond H a bond NH O NH Q3b OH 2229 CMe NEt Q1c abond H a bond NH O NH Q3c OH 2230 CMe NEt Q1c a bond H a bond NH O abond Q3a OH 2231 CMe NEt Q1c a bond H a bond NH O a bond Q3b OH 2232 CMeNEt Q1c a bond H a bond NH O a bond Q3c OH 2233 CMe NEt Q1d a bond Me abond NH S NH Q3a OH 2234 CMe NEt Q1d a bond Me a bond NH S NH Q3b OH2235 CMe NEt Q1d a bond Me a bond NH S NH Q3c OH 2236 CMe NEt Q1d a bondMe a bond NH S a bond Q3a OH 2237 CMe NEt Q1d a bond Me a bond NH S abond Q3b OH 2238 CMe NEt Q1d a bond Me a bond NH S a bond Q3c OH 2239CMe NEt Q1d a bond Me a bond NH O NH Q3a OH 2240 CMe NEt Q1d a bond Me abond NH O NH Q3b OH 2241 CMe NEt Q1d a bond Me a bond NH O NH Q3c OH2242 CMe NEt Q1d a bond Me a bond NH O a bond Q3a OH 2243 CMe NEt Q1d abond Me a bond NH O a bond Q3b OH 2244 CMe NEt Q1d a bond Me a bond NH Oa bond Q3c OH 2245 CMe NEt Q1d a bond H a bond NH S NH Q3a OH 2246 CMeNEt Q1d a bond H a bond NH S NH Q3b OH 2247 CMe NEt Q1d a bond H a bondNH S NH Q3c OH 2248 CMe NEt Q1d a bond H a bond NH S a bond Q3a OH 2249CMe NEt Q1d a bond H a bond NH S a bond Q3b OH 2250 CMe NEt Q1d a bond Ha bond NH S a bond Q3c OH 2251 CMe NEt Q1d a bond H a bond NH O NH Q3aOH 2252 CMe NEt Q1d a bond H a bond NH O NH Q3b OH 2253 CMe NEt Q1d abond H a bond NH O NH Q3c OH 2254 CMe NEt Q1d a bond H a bond NH O abond Q3a OH 2255 CMe NEt Q1d a bond H a bond NH O a bond Q3b OH 2256 CMeNEt Q1d a bond H a bond NH O a bond Q3c OH 2257 CMe NEt Q1e a bond Me abond NH S NH Q3a OH 2258 CMe NEt Q1e a bond Me a bond NH S NH Q3b OH2259 CMe NEt Q1e a bond Me a bond NH S NH Q3c OH 2260 CMe NEt Q1e a bondMe a bond NH S a bond Q3a OH 2261 CMe NEt Q1e a bond Me a bond NH S abond Q3b OH 2262 CMe NEt Q1e a bond Me a bond NH S a bond Q3c OH 2263CMe NEt Q1e a bond Me a bond NH O NH Q3a OH 2264 CMe NEt Q1e a bond Me abond NH O NH Q3b OH 2265 CMe NEt Q1e a bond Me a bond NH O NH Q3c OH2266 CMe NEt Q1e a bond Me a bond NH O a bond Q3a OH 2267 CMe NEt Q1e abond Me a bond NH O a bond Q3b OH 2268 CMe NEt Q1e a bond Me a bond NH Oa bond Q3c OH 2269 CMe NEt Q1e a bond H a bond NH S NH Q3a OH 2270 CMeNEt Q1e a bond H a bond NH S NH Q3b OH 2271 CMe NEt Q1e a bond H a bondNH S NH Q3c OH 2272 CMe NEt Q1e a bond H a bond NH S a bond Q3a OH 2273CMe NEt Q1e a bond H a bond NH S a bond Q3b OH 2274 CMe NEt Q1e a bond Ha bond NH S a bond Q3c OH 2275 CMe NEt Q1e a bond H a bond NH O NH Q3aOH 2276 CMe NEt Q1e a bond H a bond NH O NH Q3b OH 2277 CMe NEt Q1e abond H a bond NH O NH Q3c OH 2278 CMe NEt Q1e a bond H a bond NH O abond Q3a OH 2279 CMe NEt Q1e a bond H a bond NH O a bond Q3b OH 2280 CMeNEt Q1e a bond H a bond NH O a bond Q3c OH 2281 CMe NEt Q1f a bond Me abond NH S NH Q3a OH 2282 CMe NEt Q1f a bond Me a bond NH S NH Q3b OH2283 CMe NEt Q1f a bond Me a bond NH S NH Q3c OH 2284 CMe NEt Q1f a bondMe a bond NH S a bond Q3a OH 2285 CMe NEt Q1f a bond Me a bond NH S abond Q3b OH 2286 CMe NEt Q1f a bond Me a bond NH S a bond Q3c OH 2287CMe NEt Q1f a bond Me a bond NH O NH Q3a OH 2288 CMe NEt Q1f a bond Me abond NH O NH Q3b OH 2289 CMe NEt Q1f a bond Me a bond NH O NH Q3c OH2290 CMe NEt Q1f a bond Me a bond NH O a bond Q3a OH 2291 CMe NEt Q1f abond Me a bond NH O a bond Q3b OH 2292 CMe NEt Q1f a bond Me a bond NH Oa bond Q3c OH 2293 CMe NEt Q1f a bond H a bond NH S NH Q3a OH 2294 CMeNEt Q1f a bond H a bond NH S NH Q3b OH 2295 CMe NEt Q1f a bond H a bondNH S NH Q3c OH 2296 CMe NEt Q1f a bond H a bond NH S a bond Q3a OH 2297CMe NEt Q1f a bond H a bond NH S a bond Q3b OH 2298 CMe NEt Q1f a bond Ha bond NH S a bond Q3c OH 2299 CMe NEt Q1f a bond H a bond NH O NH Q3aOH 2300 CMe NEt Q1f a bond H a bond NH O NH Q3b OH 2301 CMe NEt Q1f abond H a bond NH O NH Q3c OH 2302 CMe NEt Q1f a bond H a bond NH O abond Q3a OH 2303 CMe NEt Q1f a bond H a bond NH O a bond Q3b OH 2304 CMeNEt Q1f a bond H a bond NH O a bond Q3c OH 2305 CMe NEt Q1g a bond Me abond NH S NH Q3a OH 2306 CMe NEt Q1g a bond Me a bond NH S NH Q3b OH2307 CMe NEt Q1g a bond Me a bond NH S NH Q3c OH 2308 CMe NEt Q1g a bondMe a bond NH S a bond Q3a OH 2309 CMe NEt Q1g a bond Me a bond NH S abond Q3b OH 2310 CMe NEt Q1g a bond Me a bond NH S a bond Q3c OH 2311CMe NEt Q1g a bond Me a bond NH O NH Q3a OH 2312 CMe NEt Q1g a bond Me abond NH O NH Q3b OH 2313 CMe NEt Q1g a bond Me a bond NH O NH Q3c OH2314 CMe NEt Q1g a bond Me a bond NH O a bond Q3a OH 2315 CMe NEt Q1g abond Me a bond NH O a bond Q3b OH 2316 CMe NEt Q1g a bond Me a bond NH Oa bond Q3c OH 2317 CMe NEt Q1g a bond H a bond NH S NH Q3a OH 2318 CMeNEt Q1g a bond H a bond NH S NH Q3b OH 2319 CMe NEt Q1g a bond H a bondNH S NH Q3c OH 2320 CMe NEt Q1g a bond H a bond NH S a bond Q3a OH 2321CMe NEt Q1g a bond H a bond NH S a bond Q3b OH 2322 CMe NEt Q1g a bond Ha bond NH S a bond Q3c OH 2323 CMe NEt Q1g a bond H a bond NH O NH Q3aOH 2324 CMe NEt Q1g a bond H a bond NH O NH Q3b OH 2325 CMe NEt Q1g abond H a bond NH O NH Q3c OH 2326 CMe NEt Q1g a bond H a bond NH O abond Q3a OH 2327 CMe NEt Q1g a bond H a bond NH O a bond Q3b OH 2328 CMeNEt Q1g a bond H a bond NH O a bond Q3c OH 2329 CMe NEt Q1h a bond Me abond NH S NH Q3a OH 2330 CMe NEt Q1h a bond Me a bond NH S NH Q3b OH2331 CMe NEt Q1h a bond Me a bond NH S NH Q3c OH 2332 CMe NEt Q1h a bondMe a bond NH S a bond Q3a OH 2333 CMe NEt Q1h a bond Me a bond NH S abond Q3b OH 2334 CMe NEt Q1h a bond Me a bond NH S a bond Q3c OH 2335CMe NEt Q1h a bond Me a bond NH O NH Q3a OH 2336 CMe NEt Q1h a bond Me abond NH O NH Q3b OH 2337 CMe NEt Q1h a bond Me a bond NH O NH Q3c OH2338 CMe NEt Q1h a bond Me a bond NH O a bond Q3a OH 2339 CMe NEt Q1h abond Me a bond NH O a bond Q3b OH 2340 CMe NEt Q1h a bond Me a bond NH Oa bond Q3c OH 2341 CMe NEt Q1h a bond H a bond NH S NH Q3a OH 2342 CMeNEt Q1h a bond H a bond NH S NH Q3b OH 2343 CMe NEt Q1h a bond H a bondNH S NH Q3c OH 2344 CMe NEt Q1h a bond H a bond NH S a bond Q3a OH 2345CMe NEt Q1h a bond H a bond NH S a bond Q3b OH 2346 CMe NEt Q1h a bond Ha bond NH S a bond Q3c OH 2347 CMe NEt Q1h a bond H a bond NH O NH Q3aOH 2348 CMe NEt Q1h a bond H a bond NH O NH Q3b OH 2349 CMe NEt Q1h abond H a bond NH O NH Q3c OH 2350 CMe NEt Q1h a bond H a bond NH O abond Q3a OH 2351 CMe NEt Q1h a bond H a bond NH O a bond Q3b OH 2352 CMeNEt Q1h a bond H a bond NH O a bond Q3c OH 2353 CMe NEt Q1i a bond Me abond NH S NH Q3a OH 2354 CMe NEt Q1i a bond Me a bond NH S NH Q3b OH2355 CMe NEt Q1i a bond Me a bond NH S NH Q3c OH 2356 CMe NEt Q1i a bondMe a bond NH S a bond Q3a OH 2357 CMe NEt Q1i a bond Me a bond NH S abond Q3b OH 2358 CMe NEt Q1i a bond Me a bond NH S a bond Q3c OH 2359CMe NEt Q1i a bond Me a bond NH O NH Q3a OH 2360 CMe NEt Q1i a bond Me abond NH O NH Q3b OH 2361 CMe NEt Q1i a bond Me a bond NH O NH Q3c OH2362 CMe NEt Q1i a bond Me a bond NH O a bond Q3a OH 2363 CMe NEt Q1i abond Me a bond NH O a bond Q3b OH 2364 CMe NEt Q1i a bond Me a bond NH Oa bond Q3c OH 2365 CMe NEt Q1i a bond H a bond NH S NH Q3a OH 2366 CMeNEt Q1i a bond H a bond NH S NH Q3b OH 2367 CMe NEt Q1i a bond H a bondNH S NH Q3c OH 2368 CMe NEt Q1i a bond H a bond NH S a bond Q3a OH 2369CMe NEt Q1i a bond H a bond NH S a bond Q3b OH 2370 CMe NEt Q1i a bond Ha bond NH S a bond Q3c OH 2371 CMe NEt Q1i a bond H a bond NH O NH Q3aOH 2372 CMe NEt Q1i a bond H a bond NH O NH Q3b OH 2373 CMe NEt Q1i abond H a bond NH O NH Q3c OH 2374 CMe NEt Q1i a bond H a bond NH O abond Q3a OH 2375 CMe NEt Q1i a bond H a bond NH O a bond Q3b OH 2376 CMeNEt Q1i a bond H a bond NH O a bond Q3c OH 2377 CMe NEt Q1j a bond Me abond NH S NH Q3a OH 2378 CMe NEt Q1j a bond Me a bond NH S NH Q3b OH2379 CMe NEt Q1j a bond Me a bond NH S NH Q3c OH 2380 CMe NEt Q1j a bondMe a bond NH S a bond Q3a OH 2381 CMe NEt Q1j a bond Me a bond NH S abond Q3b OH 2382 CMe NEt Q1j a bond Me a bond NH S a bond Q3c OH 2383CMe NEt Q1j a bond Me a bond NH O NH Q3a OH 2384 CMe NEt Q1j a bond Me abond NH O NH Q3b OH 2385 CMe NEt Q1j a bond Me a bond NH O NH Q3c OH2386 CMe NEt Q1j a bond Me a bond NH O a bond Q3a OH 2387 CMe NEt Q1j abond Me a bond NH O a bond Q3b OH 2388 CMe NEt Q1j a bond Me a bond NH Oa bond Q3c OH 2389 CMe NEt Q1j a bond H a bond NH S NH Q3a OH 2390 CMeNEt Q1j a bond H a bond NH S NH Q3b OH 2391 CMe NEt Q1j a bond H a bondNH S NH Q3c OH 2392 CMe NEt Q1j a bond H a bond NH S a bond Q3a OH 2393CMe NEt Q1j a bond H a bond NH S a bond Q3b OH 2394 CMe NEt Q1j a bond Ha bond NH S a bond Q3c OH 2395 CMe NEt Q1j a bond H a bond NH O NH Q3aOH 2396 CMe NEt Q1j a bond H a bond NH O NH Q3b OH 2397 CMe NEt Q1j abond H a bond NH O NH Q3c OH 2398 CMe NEt Q1j a bond H a bond NH O abond Q3a OH 2399 CMe NEt Q1j a bond H a bond NH O a bond Q3b OH 2400 CMeNEt Q1j a bond H a bond NH O a bond Q3c OH 2401 CMe S Q1a a bond Me abond NH S NH Q3a OH 2402 CMe S Q1a a bond Me a bond NH S NH Q3b OH 2403CMe S Q1a a bond Me a bond NH S NH Q3c OH 2404 CMe S Q1a a bond Me abond NH S a bond Q3a OH 2405 CMe S Q1a a bond Me a bond NH S a bond Q3bOH 2406 CMe S Q1a a bond Me a bond NH S a bond Q3c OH 2407 CMe S Q1a abond Me a bond NH O NH Q3a OH 2408 CMe S Q1a a bond Me a bond NH O NHQ3b OH 2409 CMe S Q1a a bond Me a bond NH O NH Q3c OH 2410 CMe S Q1a abond Me a bond NH O a bond Q3a OH 2411 CMe S Q1a a bond Me a bond NH O abond Q3b OH 2412 CMe S Q1a a bond Me a bond NH O a bond Q3c OH 2413 CMeS Q1a a bond H a bond NH S NH Q3a OH 2414 CMe S Q1a a bond H a bond NH SNH Q3b OH 2415 CMe S Q1a a bond H a bond NH S NH Q3c OH 2416 CMe S Q1a abond H a bond NH S a bond Q3a OH 2417 CMe S Q1a a bond H a bond NH S abond Q3b OH 2418 CMe S Q1a a bond H a bond NH S a bond Q3c OH 2419 CMe SQ1a a bond H a bond NH O NH Q3a OH 2420 CMe S Q1a a bond H a bond NH ONH Q3b OH 2421 CMe S Q1a a bond H a bond NH O NH Q3c OH 2422 CMe S Q1a abond H a bond NH O a bond Q3a OH 2423 CMe S Q1a a bond H a bond NH O abond Q3b OH 2424 CMe S Q1a a bond H a bond NH O a bond Q3c OH 2425 CMe SQ1b a bond Me a bond NH S NH Q3a OH 2426 CMe S Q1b a bond Me a bond NH SNH Q3b OH 2427 CMe S Q1b a bond Me a bond NH S NH Q3c OH 2428 CMe S Q1ba bond Me a bond NH S a bond Q3a OH 2429 CMe S Q1b a bond Me a bond NH Sa bond Q3b OH 2430 CMe S Q1b a bond Me a bond NH S a bond Q3c OH 2431CMe S Q1b a bond Me a bond NH O NH Q3a OH 2432 CMe S Q1b a bond Me abond NH O NH Q3b OH 2433 CMe S Q1b a bond Me a bond NH O NH Q3c OH 2434CMe S Q1b a bond Me a bond NH O a bond Q3a OH 2435 CMe S Q1b a bond Me abond NH O a bond Q3b OH 2436 CMe S Q1b a bond Me a bond NH O a bond Q3cOH 2437 CMe S Q1b a bond H a bond NH S NH Q3a OH 2438 CMe S Q1b a bond Ha bond NH S NH Q3b OH 2439 CMe S Q1b a bond H a bond NH S NH Q3c OH 2440CMe S Q1b a bond H a bond NH S a bond Q3a OH 2441 CMe S Q1b a bond H abond NH S a bond Q3b OH 2442 CMe S Q1b a bond H a bond NH S a bond Q3cOH 2443 CMe S Q1b a bond H a bond NH O NH Q3a OH 2444 CMe S Q1b a bond Ha bond NH O NH Q3b OH 2445 CMe S Q1b a bond H a bond NH O NH Q3c OH 2446CMe S Q1b a bond H a bond NH O a bond Q3a OH 2447 CMe S Q1b a bond H abond NH O a bond Q3b OH 2448 CMe S Q1b a bond H a bond NH O a bond Q3cOH 2449 CMe S Q1c a bond Me a bond NH S NH Q3a OH 2450 CMe S Q1c a bondMe a bond NH S NH Q3b OH 2451 CMe S Q1c a bond Me a bond NH S NH Q3c OH2452 CMe S Q1c a bond Me a bond NH S a bond Q3a OH 2453 CMe S Q1c a bondMe a bond NH S a bond Q3b OH 2454 CMe S Q1c a bond Me a bond NH S a bondQ3c OH 2455 CMe S Q1c a bond Me a bond NH O NH Q3a OH 2456 CMe S Q1c abond Me a bond NH O NH Q3b OH 2457 CMe S Q1c a bond Me a bond NH O NHQ3c OH 2458 CMe S Q1c a bond Me a bond NH O a bond Q3a OH 2459 CMe S Q1ca bond Me a bond NH O a bond Q3b OH 2460 CMe S Q1c a bond Me a bond NH Oa bond Q3c OH 2461 CMe S Q1c a bond H a bond NH S NH Q3a OH 2462 CMe SQ1c a bond H a bond NH S NH Q3b OH 2463 CMe S Q1c a bond H a bond NH SNH Q3c OH 2464 CMe S Q1c a bond H a bond NH S a bond Q3a OH 2465 CMe SQ1c a bond H a bond NH S a bond Q3b OH 2466 CMe S Q1c a bond H a bond NHS a bond Q3c OH 2467 CMe S Q1c a bond H a bond NH O NH Q3a OH 2468 CMe SQ1c a bond H a bond NH O NH Q3b OH 2469 CMe S Q1c a bond H a bond NH ONH Q3c OH 2470 CMe S Q1c a bond H a bond NH O a bond Q3a OH 2471 CMe SQ1c a bond H a bond NH O a bond Q3b OH 2472 CMe S Q1c a bond H a bond NHO a bond Q3c OH 2473 CMe S Q1d a bond Me a bond NH S NH Q3a OH 2474 CMeS Q1d a bond Me a bond NH S NH Q3b OH 2475 CMe S Q1d a bond Me a bond NHS NH Q3c OH 2476 CMe S Q1d a bond Me a bond NH S a bond Q3a OH 2477 CMeS Q1d a bond Me a bond NH S a bond Q3b OH 2478 CMe S Q1d a bond Me abond NH S a bond Q3c OH 2479 CMe S Q1d a bond Me a bond NH O NH Q3a OH2480 CMe S Q1d a bond Me a bond NH O NH Q3b OH 2481 CMe S Q1d a bond Mea bond NH O NH Q3c OH 2482 CMe S Q1d a bond Me a bond NH O a bond Q3a OH2483 CMe S Q1d a bond Me a bond NH O a bond Q3b OH 2484 CMe S Q1d a bondMe a bond NH O a bond Q3c OH 2485 CMe S Q1d a bond H a bond NH S NH Q3aOH 2486 CMe S Q1d a bond H a bond NH S NH Q3b OH 2487 CMe S Q1d a bond Ha bond NH S NH Q3c OH 2488 CMe S Q1d a bond H a bond NH S a bond Q3a OH2489 CMe S Q1d a bond H a bond NH S a bond Q3b OH 2490 CMe S Q1d a bondH a bond NH S a bond Q3c OH 2491 CMe S Q1d a bond H a bond NH O NH Q3aOH 2492 CMe S Q1d a bond H a bond NH O NH Q3b OH 2493 CMe S Q1d a bond Ha bond NH O NH Q3c OH 2494 CMe S Q1d a bond H a bond NH O a bond Q3a OH2495 CMe S Q1d a bond H a bond NH O a bond Q3b OH 2496 CMe S Q1d a bondH a bond NH O a bond Q3c OH 2497 CMe S Q1e a bond Me a bond NH S NH Q3aOH 2498 CMe S Q1e a bond Me a bond NH S NH Q3b OH 2499 CMe S Q1e a bondMe a bond NH S NH Q3c OH 2500 CMe S Q1e a bond Me a bond NH S a bond Q3aOH 2501 CMe S Q1e a bond Me a bond NH S a bond Q3b OH 2502 CMe S Q1e abond Me a bond NH S a bond Q3c OH 2503 CMe S Q1e a bond Me a bond NH ONH Q3a OH 2504 CMe S Q1e a bond Me a bond NH O NH Q3b OH 2505 CMe S Q1ea bond Me a bond NH O NH Q3c OH 2506 CMe S Q1e a bond Me a bond NH O abond Q3a OH 2507 CMe S Q1e a bond Me a bond NH O a bond Q3b OH 2508 CMeS Q1e a bond Me a bond NH O a bond Q3c OH 2509 CMe S Q1e a bond H a bondNH S NH Q3a OH 2510 CMe S Q1e a bond H a bond NH S NH Q3b OH 2511 CMe SQ1e a bond H a bond NH S NH Q3c OH 2512 CMe S Q1e a bond H a bond NH S abond Q3a OH 2513 CMe S Q1e a bond H a bond NH S a bond Q3b OH 2514 CMe SQ1e a bond H a bond NH S a bond Q3c OH 2515 CMe S Q1e a bond H a bond NHO NH Q3a OH 2516 CMe S Q1e a bond H a bond NH O NH Q3b OH 2517 CMe S Q1ea bond H a bond NH O NH Q3c OH 2518 CMe S Q1e a bond H a bond NH O abond Q3a OH 2519 CMe S Q1e a bond H a bond NH O a bond Q3b OH 2520 CMe SQ1e a bond H a bond NH O a bond Q3c OH 2521 CMe S Q1f a bond Me a bondNH S NH Q3a OH 2522 CMe S Q1f a bond Me a bond NH S NH Q3b OH 2523 CMe SQ1f a bond Me a bond NH S NH Q3c OH 2524 CMe S Q1f a bond Me a bond NH Sa bond Q3a OH 2525 CMe S Q1f a bond Me a bond NH S a bond Q3b OH 2526CMe S Q1f a bond Me a bond NH S a bond Q3c OH 2527 CMe S Q1f a bond Me abond NH O NH Q3a OH 2528 CMe S Q1f a bond Me a bond NH O NH Q3b OH 2529CMe S Q1f a bond Me a bond NH O NH Q3c OH 2530 CMe S Q1f a bond Me abond NH O a bond Q3a OH 2531 CMe S Q1f a bond Me a bond NH O a bond Q3bOH 2532 CMe S Q1f a bond Me a bond NH O a bond Q3c OH 2533 CMe S Q1f abond H a bond NH S NH Q3a OH 2534 CMe S Q1f a bond H a bond NH S NH Q3bOH 2535 CMe S Q1f a bond H a bond NH S NH Q3c OH 2536 CMe S Q1f a bond Ha bond NH S a bond Q3a OH 2537 CMe S Q1f a bond H a bond NH S a bond Q3bOH 2538 CMe S Q1f a bond H a bond NH S a bond Q3c OH 2539 CMe S Q1f abond H a bond NH O NH Q3a OH 2540 CMe S Q1f a bond H a bond NH O NH Q3bOH 2541 CMe S Q1f a bond H a bond NH O NH Q3c OH 2542 CMe S Q1f a bond Ha bond NH O a bond Q3a OH 2543 CMe S Q1f a bond H a bond NH O a bond Q3bOH 2544 CMe S Q1f a bond H a bond NH O a bond Q3c OH 2545 CMe S Q1g abond Me a bond NH S NH Q3a OH 2546 CMe S Q1g a bond Me a bond NH S NHQ3b OH 2547 CMe S Q1g a bond Me a bond NH S NH Q3c OH 2548 CMe S Q1g abond Me a bond NH S a bond Q3a OH 2549 CMe S Q1g a bond Me a bond NH S abond Q3b OH 2550 CMe S Q1g a bond Me a bond NH S a bond Q3c OH 2551 CMeS Q1g a bond Me a bond NH O NH Q3a OH 2552 CMe S Q1g a bond Me a bond NHO NH Q3b OH 2553 CMe S Q1g a bond Me a bond NH O NH Q3c OH 2554 CMe SQ1g a bond Me a bond NH O a bond Q3a OH 2555 CMe S Q1g a bond Me a bondNH O a bond Q3b OH 2556 CMe S Q1g a bond Me a bond NH O a bond Q3c OH2557 CMe S Q1g a bond H a bond NH S NH Q3a OH 2558 CMe S Q1g a bond H abond NH S NH Q3b OH 2559 CMe S Q1g a bond H a bond NH S NH Q3c OH 2560CMe S Q1g a bond H a bond NH S a bond Q3a OH 2561 CMe S Q1g a bond H abond NH S a bond Q3b OH 2562 CMe S Q1g a bond H a bond NH S a bond Q3cOH 2563 CMe S Q1g a bond H a bond NH O NH Q3a OH 2564 CMe S Q1g a bond Ha bond NH O NH Q3b OH 2565 CMe S Q1g a bond H a bond NH O NH Q3c OH 2566CMe S Q1g a bond H a bond NH O a bond Q3a OH 2567 CMe S Q1g a bond H abond NH O a bond Q3b OH 2568 CMe S Q1g a bond H a bond NH O a bond Q3cOH 2569 CMe S Q1h a bond Me a bond NH S NH Q3a OH 2570 CMe S Q1h a bondMe a bond NH S NH Q3b OH 2571 CMe S Q1h a bond Me a bond NH S NH Q3c OH2572 CMe S Q1h a bond Me a bond NH S a bond Q3a OH 2573 CMe S Q1h a bondMe a bond NH S a bond Q3b OH 2574 CMe S Q1h a bond Me a bond NH S a bondQ3c OH 2575 CMe S Q1h a bond Me a bond NH O NH Q3a OH 2576 CMe S Q1h abond Me a bond NH O NH Q3b OH 2577 CMe S Q1h a bond Me a bond NH O NHQ3c OH 2578 CMe S Q1h a bond Me a bond NH O a bond Q3a OH 2579 CMe S Q1ha bond Me a bond NH O a bond Q3b OH 2580 CMe S Q1h a bond Me a bond NH Oa bond Q3c OH 2581 CMe S Q1h a bond H a bond NH S NH Q3a OH 2582 CMe SQ1h a bond H a bond NH S NH Q3b OH 2583 CMe S Q1h a bond H a bond NH SNH Q3c OH 2584 CMe S Q1h a bond H a bond NH S a bond Q3a OH 2585 CMe SQ1h a bond H a bond NH S a bond Q3b OH 2586 CMe S Q1h a bond H a bond NHS a bond Q3c OH 2587 CMe S Q1h a bond H a bond NH O NH Q3a OH 2588 CMe SQ1h a bond H a bond NH O NH Q3b OH 2589 CMe S Q1h a bond H a bond NH ONH Q3c OH 2590 CMe S Q1h a bond H a bond NH O a bond Q3a OH 2591 CMe SQ1h a bond H a bond NH O a bond Q3b OH 2592 CMe S Q1h a bond H a bond NHO a bond Q3c OH 2593 CMe S Q1i a bond Me a bond NH S NH Q3a OH 2594 CMeS Q1i a bond Me a bond NH S NH Q3b OH 2595 CMe S Q1i a bond Me a bond NHS NH Q3c OH 2596 CMe S Q1i a bond Me a bond NH S a bond Q3a OH 2597 CMeS Q1i a bond Me a bond NH S a bond Q3b OH 2598 CMe S Q1i a bond Me abond NH S a bond Q3c OH 2599 CMe S Q1i a bond Me a bond NH O NH Q3a OH2600 CMe S Q1i a bond Me a bond NH O NH Q3b OH 2601 CMe S Q1i a bond Mea bond NH O NH Q3c OH 2602 CMe S Q1i a bond Me a bond NH O a bond Q3a OH2603 CMe S Q1i a bond Me a bond NH O a bond Q3b OH 2604 CMe S Q1i a bondMe a bond NH O a bond Q3c OH 2605 CMe S Q1i a bond H a bond NH S NH Q3aOH 2606 CMe S Q1i a bond H a bond NH S NH Q3b OH 2607 CMe S Q1i a bond Ha bond NH S NH Q3c OH 2608 CMe S Q1i a bond H a bond NH S a bond Q3a OH2609 CMe S Q1i a bond H a bond NH S a bond Q3b OH 2610 CMe S Q1i a bondH a bond NH S a bond Q3c OH 2611 CMe S Q1i a bond H a bond NH O NH Q3aOH 2612 CMe S Q1i a bond H a bond NH O NH Q3b OH 2613 CMe S Q1i a bond Ha bond NH O NH Q3c OH 2614 CMe S Q1i a bond H a bond NH O a bond Q3a OH2615 CMe S Q1i a bond H a bond NH O a bond Q3b OH 2616 CMe S Q1i a bondH a bond NH O a bond Q3c OH 2617 CMe S Q1j a bond Me a bond NH S NH Q3aOH 2618 CMe S Q1j a bond Me a bond NH S NH Q3b OH 2619 CMe S Q1j a bondMe a bond NH S NH Q3c OH 2620 CMe S Q1j a bond Me a bond NH S a bond Q3aOH 2621 CMe S Q1j a bond Me a bond NH S a bond Q3b OH 2622 CMe S Q1j abond Me a bond NH S a bond Q3c OH 2623 CMe S Q1j a bond Me a bond NH ONH Q3a OH 2624 CMe S Q1j a bond Me a bond NH O NH Q3b OH 2625 CMe S Q1ja bond Me a bond NH O NH Q3c OH 2626 CMe S Q1j a bond Me a bond NH O abond Q3a OH 2627 CMe S Q1j a bond Me a bond NH O a bond Q3b OH 2628 CMeS Q1j a bond Me a bond NH O a bond Q3c OH 2629 CMe S Q1j a bond H a bondNH S NH Q3a OH 2630 CMe S Q1j a bond H a bond NH S NH Q3b OH 2631 CMe SQ1j a bond H a bond NH S NH Q3c OH 2632 CMe S Q1j a bond H a bond NH S abond Q3a OH 2633 CMe S Q1j a bond H a bond NH S a bond Q3b OH 2634 CMe SQ1j a bond H a bond NH S a bond Q3c OH 2635 CMe S Q1j a bond H a bond NHO NH Q3a OH 2636 CMe S Q1j a bond H a bond NH O NH Q3b OH 2637 CMe S Q1ja bond H a bond NH O NH Q3c OH 2638 CMe S Q1j a bond H a bond NH O abond Q3a OH 2639 CMe S Q1j a bond H a bond NH O a bond Q3b OH 2640 CMe SQ1j a bond H a bond NH O a bond Q3c OH 2641 CMe O Q1a a bond Me a bondNH S NH Q3a OH 2642 CMe O Q1a a bond Me a bond NH S NH Q3b OH 2643 CMe OQ1a a bond Me a bond NH S NH Q3c OH 2644 CMe O Q1a a bond Me a bond NH Sa bond Q3a OH 2645 CMe O Q1a a bond Me a bond NH S a bond Q3b OH 2646CMe O Q1a a bond Me a bond NH S a bond Q3c OH 2647 CMe O Q1a a bond Me abond NH O NH Q3a OH 2648 CMe O Q1a a bond Me a bond NH O NH Q3b OH 2649CMe O Q1a a bond Me a bond NH O NH Q3c OH 2650 CMe O Q1a a bond Me abond NH O a bond Q3a OH 2651 CMe O Q1a a bond Me a bond NH O a bond Q3bOH 2652 CMe O Q1a a bond Me a bond NH O a bond Q3c OH 2653 CMe O Q1a abond H a bond NH S NH Q3a OH 2654 CMe O Q1a a bond H a bond NH S NH Q3bOH 2655 CMe O Q1a a bond H a bond NH S NH Q3c OH 2656 CMe O Q1a a bond Ha bond NH S a bond Q3a OH 2657 CMe O Q1a a bond H a bond NH S a bond Q3bOH 2658 CMe O Q1a a bond H a bond NH S a bond Q3c OH 2659 CMe O Q1a abond H a bond NH O NH Q3a OH 2660 CMe O Q1a a bond H a bond NH O NH Q3bOH 2661 CMe O Q1a a bond H a bond NH O NH Q3c OH 2662 CMe O Q1a a bond Ha bond NH O a bond Q3a OH 2663 CMe O Q1a a bond H a bond NH O a bond Q3bOH 2664 CMe O Q1a a bond H a bond NH O a bond Q3c OH 2665 CMe O Q1b abond Me a bond NH S NH Q3a OH 2666 CMe O Q1b a bond Me a bond NH S NHQ3b OH 2667 CMe O Q1b a bond Me a bond NH S NH Q3c OH 2668 CMe O Q1b abond Me a bond NH S a bond Q3a OH 2669 CMe O Q1b a bond Me a bond NH S abond Q3b OH 2670 CMe O Q1b a bond Me a bond NH S a bond Q3c OH 2671 CMeO Q1b a bond Me a bond NH O NH Q3a OH 2672 CMe O Q1b a bond Me a bond NHO NH Q3b OH 2673 CMe O Q1b a bond Me a bond NH O NH Q3c OH 2674 CMe OQ1b a bond Me a bond NH O a bond Q3a OH 2675 CMe O Q1b a bond Me a bondNH O a bond Q3b OH 2676 CMe O Q1b a bond Me a bond NH O a bond Q3c OH2677 CMe O Q1b a bond H a bond NH S NH Q3a OH 2678 CMe O Q1b a bond H abond NH S NH Q3b OH 2679 CMe O Q1b a bond H a bond NH S NH Q3c OH 2680CMe O Q1b a bond H a bond NH S a bond Q3a OH 2681 CMe O Q1b a bond H abond NH S a bond Q3b OH 2682 CMe O Q1b a bond H a bond NH S a bond Q3cOH 2683 CMe O Q1b a bond H a bond NH O NH Q3a OH 2684 CMe O Q1b a bond Ha bond NH O NH Q3b OH 2685 CMe O Q1b a bond H a bond NH O NH Q3c OH 2686CMe O Q1b a bond H a bond NH O a bond Q3a OH 2687 CMe O Q1b a bond H abond NH O a bond Q3b OH 2688 CMe O Q1b a bond H a bond NH O a bond Q3cOH 2689 CMe O Q1c a bond Me a bond NH S NH Q3a OH 2690 CMe O Q1c a bondMe a bond NH S NH Q3b OH 2691 CMe O Q1c a bond Me a bond NH S NH Q3c OH2692 CMe O Q1c a bond Me a bond NH S a bond Q3a OH 2693 CMe O Q1c a bondMe a bond NH S a bond Q3b OH 2694 CMe O Q1c a bond Me a bond NH S a bondQ3c OH 2695 CMe O Q1c a bond Me a bond NH O NH Q3a OH 2696 CMe O Q1c abond Me a bond NH O NH Q3b OH 2697 CMe O Q1c a bond Me a bond NH O NHQ3c OH 2698 CMe O Q1c a bond Me a bond NH O a bond Q3a OH 2699 CMe O Q1ca bond Me a bond NH O a bond Q3b OH 2700 CMe O Q1c a bond Me a bond NH Oa bond Q3c OH 2701 CMe O Q1c a bond H a bond NH S NH Q3a OH 2702 CMe OQ1c a bond H a bond NH S NH Q3b OH 2703 CMe O Q1c a bond H a bond NH SNH Q3c OH 2704 CMe O Q1c a bond H a bond NH S a bond Q3a OH 2705 CMe OQ1c a bond H a bond NH S a bond Q3b OH 2706 CMe O Q1c a bond H a bond NHS a bond Q3c OH 2707 CMe O Q1c a bond H a bond NH O NH Q3a OH 2708 CMe OQ1c a bond H a bond NH O NH Q3b OH 2709 CMe O Q1c a bond H a bond NH ONH Q3c OH 2710 CMe O Q1c a bond H a bond NH O a bond Q3a OH 2711 CMe OQ1c a bond H a bond NH O a bond Q3b OH 2712 CMe O Q1c a bond H a bond NHO a bond Q3c OH 2713 CMe O Q1d a bond Me a bond NH S NH Q3a OH 2714 CMeO Q1d a bond Me a bond NH S NH Q3b OH 2715 CMe O Q1d a bond Me a bond NHS NH Q3c OH 2716 CMe O Q1d a bond Me a bond NH S a bond Q3a OH 2717 CMeO Q1d a bond Me a bond NH S a bond Q3b OH 2718 CMe O Q1d a bond Me abond NH S a bond Q3c OH 2719 CMe O Q1d a bond Me a bond NH O NH Q3a OH2720 CMe O Q1d a bond Me a bond NH O NH Q3b OH 2721 CMe O Q1d a bond Mea bond NH O NH Q3c OH 2722 CMe O Q1d a bond Me a bond NH O a bond Q3a OH2723 CMe O Q1d a bond Me a bond NH O a bond Q3b OH 2724 CMe O Q1d a bondMe a bond NH O a bond Q3c OH 2725 CMe O Q1d a bond H a bond NH S NH Q3aOH 2726 CMe O Q1d a bond H a bond NH S NH Q3b OH 2727 CMe O Q1d a bond Ha bond NH S NH Q3c OH 2728 CMe O Q1d a bond H a bond NH S a bond Q3a OH2729 CMe O Q1d a bond H a bond NH S a bond Q3b OH 2730 CMe O Q1d a bondH a bond NH S a bond Q3c OH 2731 CMe O Q1d a bond H a bond NH O NH Q3aOH 2732 CMe O Q1d a bond H a bond NH O NH Q3b OH 2733 CMe O Q1d a bond Ha bond NH O NH Q3c OH 2734 CMe O Q1d a bond H a bond NH O a bond Q3a OH2735 CMe O Q1d a bond H a bond NH O a bond Q3b OH 2736 CMe O Q1d a bondH a bond NH O a bond Q3c OH 2737 CMe O Q1e a bond Me a bond NH S NH Q3aOH 2738 CMe O Q1e a bond Me a bond NH S NH Q3b OH 2739 CMe O Q1e a bondMe a bond NH S NH Q3c OH 2740 CMe O Q1e a bond Me a bond NH S a bond Q3aOH 2741 CMe O Q1e a bond Me a bond NH S a bond Q3b OH 2742 CMe O Q1e abond Me a bond NH S a bond Q3c OH 2743 CMe O Q1e a bond Me a bond NH ONH Q3a OH 2744 CMe O Q1e a bond Me a bond NH O NH Q3b OH 2745 CMe O Q1ea bond Me a bond NH O NH Q3c OH 2746 CMe O Q1e a bond Me a bond NH O abond Q3a OH 2747 CMe O Q1e a bond Me a bond NH O a bond Q3b OH 2748 CMeO Q1e a bond Me a bond NH O a bond Q3c OH 2749 CMe O Q1e a bond H a bondNH S NH Q3a OH 2750 CMe O Q1e a bond H a bond NH S NH Q3b OH 2751 CMe OQ1e a bond H a bond NH S NH Q3c OH 2752 CMe O Q1e a bond H a bond NH S abond Q3a OH 2753 CMe O Q1e a bond H a bond NH S a bond Q3b OH 2754 CMe OQ1e a bond H a bond NH S a bond Q3c OH 2755 CMe O Q1e a bond H a bond NHO NH Q3a OH 2756 CMe O Q1e a bond H a bond NH O NH Q3b OH 2757 CMe O Q1ea bond H a bond NH O NH Q3c OH 2758 CMe O Q1e a bond H a bond NH O abond Q3a OH 2759 CMe O Q1e a bond H a bond NH O a bond Q3b OH 2760 CMe OQ1e a bond H a bond NH O a bond Q3c OH 2761 CMe O Q1f a bond Me a bondNH S NH Q3a OH 2762 CMe O Q1f a bond Me a bond NH S NH Q3b OH 2763 CMe OQ1f a bond Me a bond NH S NH Q3c OH 2764 CMe O Q1f a bond Me a bond NH Sa bond Q3a OH 2765 CMe O Q1f a bond Me a bond NH S a bond Q3b OH 2766CMe O Q1f a bond Me a bond NH S a bond Q3c OH 2767 CMe O Q1f a bond Me abond NH O NH Q3a OH 2768 CMe O Q1f a bond Me a bond NH O NH Q3b OH 2769CMe O Q1f a bond Me a bond NH O NH Q3c OH 2770 CMe O Q1f a bond Me abond NH O a bond Q3a OH 2771 CMe O Q1f a bond Me a bond NH O a bond Q3bOH 2772 CMe O Q1f a bond Me a bond NH O a bond Q3c OH 2773 CMe O Q1f abond H a bond NH S NH Q3a OH 2774 CMe O Q1f a bond H a bond NH S NH Q3bOH 2775 CMe O Q1f a bond H a bond NH S NH Q3c OH 2776 CMe O Q1f a bond Ha bond NH S a bond Q3a OH 2777 CMe O Q1f a bond H a bond NH S a bond Q3bOH 2778 CMe O Q1f a bond H a bond NH S a bond Q3c OH 2779 CMe O Q1f abond H a bond NH O NH Q3a OH 2780 CMe O Q1f a bond H a bond NH O NH Q3bOH 2781 CMe O Q1f a bond H a bond NH O NH Q3c OH 2782 CMe O Q1f a bond Ha bond NH O a bond Q3a OH 2783 CMe O Q1f a bond H a bond NH O a bond Q3bOH 2784 CMe O Q1f a bond H a bond NH O a bond Q3c OH 2785 CMe O Q1g abond Me a bond NH S NH Q3a OH 2786 CMe O Q1g a bond Me a bond NH S NHQ3b OH 2787 CMe O Q1g a bond Me a bond NH S NH Q3c OH 2788 CMe O Q1g abond Me a bond NH S a bond Q3a OH 2789 CMe O Q1g a bond Me a bond NH S abond Q3b OH 2790 CMe O Q1g a bond Me a bond NH S a bond Q3c OH 2791 CMeO Q1g a bond Me a bond NH O NH Q3a OH 2792 CMe O Q1g a bond Me a bond NHO NH Q3b OH 2793 CMe O Q1g a bond Me a bond NH O NH Q3c OH 2794 CMe OQ1g a bond Me a bond NH O a bond Q3a OH 2795 CMe O Q1g a bond Me a bondNH O a bond Q3b OH 2796 CMe O Q1g a bond Me a bond NH O a bond Q3c OH2797 CMe O Q1g a bond H a bond NH S NH Q3a OH 2798 CMe O Q1g a bond H abond NH S NH Q3b OH 2799 CMe O Q1g a bond H a bond NH S NH Q3c OH 2800CMe O Q1g a bond H a bond NH S a bond Q3a OH 2801 CMe O Q1g a bond H abond NH S a bond Q3b OH 2802 CMe O Q1g a bond H a bond NH S a bond Q3cOH 2803 CMe O Q1g a bond H a bond NH O NH Q3a OH 2804 CMe O Q1g a bond Ha bond NH O NH Q3b OH 2805 CMe O Q1g a bond H a bond NH O NH Q3c OH 2806CMe O Q1g a bond H a bond NH O a bond Q3a OH 2807 CMe O Q1g a bond H abond NH O a bond Q3b OH 2808 CMe O Q1g a bond H a bond NH O a bond Q3cOH 2809 CMe O Q1h a bond Me a bond NH S NH Q3a OH 2810 CMe O Q1h a bondMe a bond NH S NH Q3b OH 2811 CMe O Q1h a bond Me a bond NH S NH Q3c OH2812 CMe O Q1h a bond Me a bond NH S a bond Q3a OH 2813 CMe O Q1h a bondMe a bond NH S a bond Q3b OH 2814 CMe O Q1h a bond Me a bond NH S a bondQ3c OH 2815 CMe O Q1h a bond Me a bond NH O NH Q3a OH 2816 CMe O Q1h abond Me a bond NH O NH Q3b OH 2817 CMe O Q1h a bond Me a bond NH O NHQ3c OH 2818 CMe O Q1h a bond Me a bond NH O a bond Q3a OH 2819 CMe O Q1ha bond Me a bond NH O a bond Q3b OH 2820 CMe O Q1h a bond Me a bond NH Oa bond Q3c OH 2821 CMe O Q1h a bond H a bond NH S NH Q3a OH 2822 CMe OQ1h a bond H a bond NH S NH Q3b OH 2823 CMe O Q1h a bond H a bond NH SNH Q3c OH 2824 CMe O Q1h a bond H a bond NH S a bond Q3a OH 2825 CMe OQ1h a bond H a bond NH S a bond Q3b OH 2826 CMe O Q1h a bond H a bond NHS a bond Q3c OH 2827 CMe O Q1h a bond H a bond NH O NH Q3a OH 2828 CMe OQ1h a bond H a bond NH O NH Q3b OH 2829 CMe O Q1h a bond H a bond NH ONH Q3c OH 2830 CMe O Q1h a bond H a bond NH O a bond Q3a OH 2831 CMe OQ1h a bond H a bond NH O a bond Q3b OH 2832 CMe O Q1h a bond H a bond NHO a bond Q3c OH 2833 CMe O Q1i a bond Me a bond NH S NH Q3a OH 2834 CMeO Q1i a bond Me a bond NH S NH Q3b OH 2835 CMe O Q1i a bond Me a bond NHS NH Q3c OH 2836 CMe O Q1i a bond Me a bond NH S a bond Q3a OH 2837 CMeO Q1i a bond Me a bond NH S a bond Q3b OH 2838 CMe O Q1i a bond Me abond NH S a bond Q3c OH 2839 CMe O Q1i a bond Me a bond NH O NH Q3a OH2840 CMe O Q1i a bond Me a bond NH O NH Q3b OH 2841 CMe O Q1i a bond Mea bond NH O NH Q3c OH 2842 CMe O Q1i a bond Me a bond NH O a bond Q3a OH2843 CMe O Q1i a bond Me a bond NH O a bond Q3b OH 2844 CMe O Q1i a bondMe a bond NH O a bond Q3c OH 2845 CMe O Q1i a bond H a bond NH S NH Q3aOH 2846 CMe O Q1i a bond H a bond NH S NH Q3b OH 2847 CMe O Q1i a bond Ha bond NH S NH Q3c OH 2848 CMe O Q1i a bond H a bond NH S a bond Q3a OH2849 CMe O Q1i a bond H a bond NH S a bond Q3b OH 2850 CMe O Q1i a bondH a bond NH S a bond Q3c OH 2851 CMe O Q1i a bond H a bond NH O NH Q3aOH 2852 CMe O Q1i a bond H a bond NH O NH Q3b OH 2853 CMe O Q1i a bond Ha bond NH O NH Q3c OH 2854 CMe O Q1i a bond H a bond NH O a bond Q3a OH2855 CMe O Q1i a bond H a bond NH O a bond Q3b OH 2856 CMe O Q1i a bondH a bond NH O a bond Q3c OH 2857 CMe O Q1j a bond Me a bond NH S NH Q3aOH 2858 CMe O Q1j a bond Me a bond NH S NH Q3b OH 2859 CMe O Q1j a bondMe a bond NH S NH Q3c OH 2860 CMe O Q1j a bond Me a bond NH S a bond Q3aOH 2861 CMe O Q1j a bond Me a bond NH S a bond Q3b OH 2862 CMe O Q1j abond Me a bond NH S a bond Q3c OH 2863 CMe O Q1j a bond Me a bond NH ONH Q3a OH 2864 CMe O Q1j a bond Me a bond NH O NH Q3b OH 2865 CMe O Q1ja bond Me a bond NH O NH Q3c OH 2866 CMe O Q1j a bond Me a bond NH O abond Q3a OH 2867 CMe O Q1j a bond Me a bond NH O a bond Q3b OH 2868 CMeO Q1j a bond Me a bond NH O a bond Q3c OH 2869 CMe O Q1j a bond H a bondNH S NH Q3a OH 2870 CMe O Q1j a bond H a bond NH S NH Q3b OH 2871 CMe OQ1j a bond H a bond NH S NH Q3c OH 2872 CMe O Q1j a bond H a bond NH S abond Q3a OH 2873 CMe O Q1j a bond H a bond NH S a bond Q3b OH 2874 CMe OQ1j a bond H a bond NH S a bond Q3c OH 2875 CMe O Q1j a bond H a bond NHO NH Q3a OH 2876 CMe O Q1j a bond H a bond NH O NH Q3b OH 2877 CMe O Q1ja bond H a bond NH O NH Q3c OH 2878 CMe O Q1j a bond H a bond NH O abond Q3a OH 2879 CMe O Q1j a bond H a bond NH O a bond Q3b OH 2880 CMe OQ1j a bond H a bond NH O a bond Q3c OH 2881 N NMe Q1k a bond Me a bondNH O a bond Q3a OH 2882 N NMe Q1k a bond Me a bond NH O a bond Q3d OH2883 N NMe Q1k a bond Me a bond NH O a bond Q3e OH 2884 N NMe Q1k a bondMe a bond NH O a bond Q3f OH 2885 N NMe Q1k a bond Me a bond NH O NH Q3aOH 2886 N NMe Q1k a bond Me a bond NH O NH Q3d OH 2887 N NMe Q1k a bondMe a bond NH O NH Q3e OH 2888 N NMe Q1k a bond Me a bond NH O NH Q3f OH2889 N NMe Q1k a bond Me a bond NH S a bond Q3a OH 2890 N NMe Q1k a bondMe a bond NH S a bond Q3d OH 2891 N NMe Q1k a bond Me a bond NH S a bondQ3e OH 2892 N NMe Q1k a bond Me a bond NH S a bond Q3f OH 2893 N NMe Q1ka bond Me a bond NH S NH Q3a OH 2894 N NMe Q1k a bond Me a bond NH S NHQ3d OH 2895 N NMe Q1k a bond Me a bond NH S NH Q3e OH 2896 N NMe Q1k abond Me a bond NH S NH Q3f OH 2897 N NMe Q1l a bond Me a bond NH O abond Q3a OH 2898 N NMe Q1l a bond Me a bond NH O a bond Q3d OH 2899 NNMe Q1l a bond Me a bond NH O a bond Q3e OH 2900 N NMe Q1l a bond Me abond NH O a bond Q3f OH 2901 N NMe Q1l a bond Me a bond NH O NH Q3a OH2902 N NMe Q1l a bond Me a bond NH O NH Q3d OH 2903 N NMe Q1l a bond Mea bond NH O NH Q3e OH 2904 N NMe Q1l a bond Me a bond NH O NH Q3f OH2905 N NMe Q1l a bond Me a bond NH S a bond Q3a OH 2906 N NMe Q1l a bondMe a bond NH S a bond Q3d OH 2907 N NMe Q1l a bond Me a bond NH S a bondQ3e OH 2908 N NMe Q1l a bond Me a bond NH S a bond Q3f OH 2909 N NMe Q1la bond Me a bond NH S NH Q3a OH 2910 N NMe Q1l a bond Me a bond NH S NHQ3d OH 2911 N NMe Q1l a bond Me a bond NH S NH Q3e OH 2912 N NMe Q1l abond Me a bond NH S NH Q3f OH 2913 N NMe Q1m a bond Me a bond NH O abond Q3a OH 2914 N NMe Q1m a bond Me a bond NH O a bond Q3d OH 2915 NNMe Q1m a bond Me a bond NH O a bond Q3e OH 2916 N NMe Q1m a bond Me abond NH O a bond Q3f OH 2917 N NMe Q1m a bond Me a bond NH O NH Q3a OH2918 N NMe Q1m a bond Me a bond NH O NH Q3d OH 2919 N NMe Q1m a bond Mea bond NH O NH Q3e OH 2920 N NMe Q1m a bond Me a bond NH O NH Q3f OH2921 N NMe Q1m a bond Me a bond NH S a bond Q3a OH 2922 N NMe Q1m a bondMe a bond NH S a bond Q3d OH 2923 N NMe Q1m a bond Me a bond NH S a bondQ3e OH 2924 N NMe Q1m a bond Me a bond NH S a bond Q3f OH 2925 N NMe Q1ma bond Me a bond NH S NH Q3a OH 2926 N NMe Q1m a bond Me a bond NH S NHQ3d OH 2927 N NMe Q1m a bond Me a bond NH S NH Q3e OH 2928 N NMe Q1m abond Me a bond NH S NH Q3f OH 2929 N NMe Q1n a bond Me a bond NH O abond Q3a OH 2930 N NMe Q1n a bond Me a bond NH O a bond Q3d OH 2931 NNMe Q1n a bond Me a bond NH O a bond Q3e OH 2932 N NMe Q1n a bond Me abond NH O a bond Q3f OH 2933 N NMe Q1n a bond Me a bond NH O NH Q3a OH2934 N NMe Q1n a bond Me a bond NH O NH Q3d OH 2935 N NMe Q1n a bond Mea bond NH O NH Q3e OH 2936 N NMe Q1n a bond Me a bond NH O NH Q3f OH2937 N NMe Q1n a bond Me a bond NH S a bond Q3a OH 2938 N NMe Q1n a bondMe a bond NH S a bond Q3d OH 2939 N NMe Q1n a bond Me a bond NH S a bondQ3e OH 2940 N NMe Q1n a bond Me a bond NH S a bond Q3f OH 2941 N NMe Q1na bond Me a bond NH S NH Q3a OH 2942 N NMe Q1n a bond Me a bond NH S NHQ3d OH 2943 N NMe Q1n a bond Me a bond NH S NH Q3e OH 2944 N NMe Q1n abond Me a bond NH S NH Q3f OH 2945 N NEt Q1k a bond Me a bond NH O abond Q3a OH 2946 N NEt Q1k a bond Me a bond NH O a bond Q3d OH 2947 NNEt Q1k a bond Me a bond NH O a bond Q3e OH 2948 N NEt Q1k a bond Me abond NH O a bond Q3f OH 2949 N NEt Q1k a bond Me a bond NH O NH Q3a OH2950 N NEt Q1k a bond Me a bond NH O NH Q3d OH 2951 N NEt Q1k a bond Mea bond NH O NH Q3e OH 2952 N NEt Q1k a bond Me a bond NH O NH Q3f OH2953 N NEt Q1k a bond Me a bond NH S a bond Q3a OH 2954 N NEt Q1k a bondMe a bond NH S a bond Q3d OH 2955 N NEt Q1k a bond Me a bond NH S a bondQ3e OH 2956 N NEt Q1k a bond Me a bond NH S a bond Q3f OH 2957 N NEt Q1ka bond Me a bond NH S NH Q3a OH 2958 N NEt Q1k a bond Me a bond NH S NHQ3d OH 2959 N NEt Q1k a bond Me a bond NH S NH Q3e OH 2960 N NEt Q1k abond Me a bond NH S NH Q3f OH 2961 N NEt Q1l a bond Me a bond NH O abond Q3a OH 2962 N NEt Q1l a bond Me a bond NH O a bond Q3d OH 2963 NNEt Q1l a bond Me a bond NH O a bond Q3e OH 2964 N NEt Q1l a bond Me abond NH O a bond Q3f OH 2965 N NEt Q1l a bond Me a bond NH O NH Q3a OH2966 N NEt Q1l a bond Me a bond NH O NH Q3d OH 2967 N NEt Q1l a bond Mea bond NH O NH Q3e OH 2968 N NEt Q1l a bond Me a bond NH O NH Q3f OH2969 N NEt Q1l a bond Me a bond NH S a bond Q3a OH 2970 N NEt Q1l a bondMe a bond NH S a bond Q3d OH 2971 N NEt Q1l a bond Me a bond NH S a bondQ3e OH 2972 N NEt Q1l a bond Me a bond NH S a bond Q3f OH 2973 N NEt Q1la bond Me a bond NH S NH Q3a OH 2974 N NEt Q1l a bond Me a bond NH S NHQ3d OH 2975 N NEt Q1l a bond Me a bond NH S NH Q3e OH 2976 N NEt Q1l abond Me a bond NH S NH Q3f OH 2977 N NEt Q1m a bond Me a bond NH O abond Q3a OH 2978 N NEt Q1m a bond Me a bond NH O a bond Q3d OH 2979 NNEt Q1m a bond Me a bond NH O a bond Q3e OH 2980 N NEt Q1m a bond Me abond NH O a bond Q3f OH 2981 N NEt Q1m a bond Me a bond NH O NH Q3a OH2982 N NEt Q1m a bond Me a bond NH O NH Q3d OH 2983 N NEt Q1m a bond Mea bond NH O NH Q3e OH 2984 N NEt Q1m a bond Me a bond NH O NH Q3f OH2985 N NEt Q1m a bond Me a bond NH S a bond Q3a OH 2986 N NEt Q1m a bondMe a bond NH S a bond Q3d OH 2987 N NEt Q1m a bond Me a bond NH S a bondQ3e OH 2988 N NEt Q1m a bond Me a bond NH S a bond Q3f OH 2989 N NEt Q1ma bond Me a bond NH S NH Q3a OH 2990 N NEt Q1m a bond Me a bond NH S NHQ3d OH 2991 N NEt Q1m a bond Me a bond NH S NH Q3e OH 2992 N NEt Q1m abond Me a bond NH S NH Q3f OH 2993 N NEt Q1n a bond Me a bond NH O abond Q3a OH 2994 N NEt Q1n a bond Me a bond NH O a bond Q3d OH 2995 NNEt Q1n a bond Me a bond NH O a bond Q3e OH 2996 N NEt Q1n a bond Me abond NH O a bond Q3f OH 2997 N NEt Q1n a bond Me a bond NH O NH Q3a OH2998 N NEt Q1n a bond Me a bond NH O NH Q3d OH 2999 N NEt Q1n a bond Mea bond NH O NH Q3e OH 3000 N NEt Q1n a bond Me a bond NH O NH Q3f OH3001 N NEt Q1n a bond Me a bond NH S a bond Q3a OH 3002 N NEt Q1n a bondMe a bond NH S a bond Q3d OH 3003 N NEt Q1n a bond Me a bond NH S a bondQ3e OH 3004 N NEt Q1n a bond Me a bond NH S a bond Q3f OH 3005 N NEt Q1na bond Me a bond NH S NH Q3a OH 3006 N NEt Q1n a bond Me a bond NH S NHQ3d OH 3007 N NEt Q1n a bond Me a bond NH S NH Q3e OH 3008 N NEt Q1n abond Me a bond NH S NH Q3f OH 3009 N S Q1k a bond Me a bond NH O a bondQ3a OH 3010 N S Q1k a bond Me a bond NH O a bond Q3d OH 3011 N S Q1k abond Me a bond NH O a bond Q3e OH 3012 N S Q1k a bond Me a bond NH O abond Q3f OH 3013 N S Q1k a bond Me a bond NH O NH Q3a OH 3014 N S Q1k abond Me a bond NH O NH Q3d OH 3015 N S Q1k a bond Me a bond NH O NH Q3eOH 3016 N S Q1k a bond Me a bond NH O NH Q3f OH 3017 N S Q1k a bond Me abond NH S a bond Q3a OH 3018 N S Q1k a bond Me a bond NH S a bond Q3d OH3019 N S Q1k a bond Me a bond NH S a bond Q3e OH 3020 N S Q1k a bond Mea bond NH S a bond Q3f OH 3021 N S Q1k a bond Me a bond NH S NH Q3a OH3022 N S Q1k a bond Me a bond NH S NH Q3d OH 3023 N S Q1k a bond Me abond NH S NH Q3e OH 3024 N S Q1k a bond Me a bond NH S NH Q3f OH 3025 NS Q1l a bond Me a bond NH O a bond Q3a OH 3026 N S Q1l a bond Me a bondNH O a bond Q3d OH 3027 N S Q1l a bond Me a bond NH O a bond Q3e OH 3028N S Q1l a bond Me a bond NH O a bond Q3f OH 3029 N S Q1l a bond Me abond NH O NH Q3a OH 3030 N S Q1l a bond Me a bond NH O NH Q3d OH 3031 NS Q1l a bond Me a bond NH O NH Q3e OH 3032 N S Q1l a bond Me a bond NH ONH Q3f OH 3033 N S Q1l a bond Me a bond NH S a bond Q3a OH 3034 N S Q1la bond Me a bond NH S a bond Q3d OH 3035 N S Q1l a bond Me a bond NH S abond Q3e OH 3036 N S Q1l a bond Me a bond NH S a bond Q3f OH 3037 N SQ1l a bond Me a bond NH S NH Q3a OH 3038 N S Q1l a bond Me a bond NH SNH Q3d OH 3039 N S Q1l a bond Me a bond NH S NH Q3e OH 3040 N S Q1l abond Me a bond NH S NH Q3f OH 3041 N S Q1m a bond Me a bond NH O a bondQ3a OH 3042 N S Q1m a bond Me a bond NH O a bond Q3d OH 3043 N S Q1m abond Me a bond NH O a bond Q3e OH 3044 N S Q1m a bond Me a bond NH O abond Q3f OH 3045 N S Q1m a bond Me a bond NH O NH Q3a OH 3046 N S Q1m abond Me a bond NH O NH Q3d OH 3047 N S Q1m a bond Me a bond NH O NH Q3eOH 3048 N S Q1m a bond Me a bond NH O NH Q3f OH 3049 N S Q1m a bond Me abond NH S a bond Q3a OH 3050 N S Q1m a bond Me a bond NH S a bond Q3d OH3051 N S Q1m a bond Me a bond NH S a bond Q3e OH 3052 N S Q1m a bond Mea bond NH S a bond Q3f OH 3053 N S Q1m a bond Me a bond NH S NH Q3a OH3054 N S Q1m a bond Me a bond NH S NH Q3d OH 3055 N S Q1m a bond Me abond NH S NH Q3e OH 3056 N S Q1m a bond Me a bond NH S NH Q3f OH 3057 NS Q1n a bond Me a bond NH O a bond Q3a OH 3058 N S Q1n a bond Me a bondNH O a bond Q3d OH 3059 N S Q1n a bond Me a bond NH O a bond Q3e OH 3060N S Q1n a bond Me a bond NH O a bond Q3f OH 3061 N S Q1n a bond Me abond NH O NH Q3a OH 3062 N S Q1n a bond Me a bond NH O NH Q3d OH 3063 NS Q1n a bond Me a bond NH O NH Q3e OH 3064 N S Q1n a bond Me a bond NH ONH Q3f OH 3065 N S Q1n a bond Me a bond NH S a bond Q3a OH 3066 N S Q1na bond Me a bond NH S a bond Q3d OH 3067 N S Q1n a bond Me a bond NH S abond Q3e OH 3068 N S Q1n a bond Me a bond NH S a bond Q3f OH 3069 N SQ1n a bond Me a bond NH S NH Q3a OH 3070 N S Q1n a bond Me a bond NH SNH Q3d OH 3071 N S Q1n a bond Me a bond NH S NH Q3e OH 3072 N S Q1n abond Me a bond NH S NH Q3f OH 3073 N O Q1k a bond Me a bond NH O a bondQ3a OH 3074 N O Q1k a bond Me a bond NH O a bond Q3d OH 3075 N O Q1k abond Me a bond NH O a bond Q3e OH 3076 N O Q1k a bond Me a bond NH O abond Q3f OH 3077 N O Q1k a bond Me a bond NH O NH Q3a OH 3078 N O Q1k abond Me a bond NH O NH Q3d OH 3079 N O Q1k a bond Me a bond NH O NH Q3eOH 3080 N O Q1k a bond Me a bond NH O NH Q3f OH 3081 N O Q1k a bond Me abond NH S a bond Q3a OH 3082 N O Q1k a bond Me a bond NH S a bond Q3d OH3083 N O Q1k a bond Me a bond NH S a bond Q3e OH 3084 N O Q1k a bond Mea bond NH S a bond Q3f OH 3085 N O Q1k a bond Me a bond NH S NH Q3a OH3086 N O Q1k a bond Me a bond NH S NH Q3d OH 3087 N O Q1k a bond Me abond NH S NH Q3e OH 3088 N O Q1k a bond Me a bond NH S NH Q3f OH 3089 NO Q1l a bond Me a bond NH O a bond Q3a OH 3090 N O Q1l a bond Me a bondNH O a bond Q3d OH 3091 N O Q1l a bond Me a bond NH O a bond Q3e OH 3092N O Q1l a bond Me a bond NH O a bond Q3f OH 3093 N O Q1l a bond Me abond NH O NH Q3a OH 3094 N O Q1l a bond Me a bond NH O NH Q3d OH 3095 NO Q1l a bond Me a bond NH O NH Q3e OH 3096 N O Q1l a bond Me a bond NH ONH Q3f OH 3097 N O Q1l a bond Me a bond NH S a bond Q3a OH 3098 N O Q1la bond Me a bond NH S a bond Q3d OH 3099 N O Q1l a bond Me a bond NH S abond Q3e OH 3100 N O Q1l a bond Me a bond NH S a bond Q3f OH 3101 N OQ1l a bond Me a bond NH S NH Q3a OH 3102 N O Q1l a bond Me a bond NH SNH Q3d OH 3103 N O Q1l a bond Me a bond NH S NH Q3e OH 3104 N O Q1l abond Me a bond NH S NH Q3f OH 3105 N O Q1m a bond Me a bond NH O a bondQ3a OH 3106 N O Q1m a bond Me a bond NH O a bond Q3d OH 3107 N O Q1m abond Me a bond NH O a bond Q3e OH 3108 N O Q1m a bond Me a bond NH O abond Q3f OH 3109 N O Q1m a bond Me a bond NH O NH Q3a OH 3110 N O Q1m abond Me a bond NH O NH Q3d OH 3111 N O Q1m a bond Me a bond NH O NH Q3eOH 3112 N O Q1m a bond Me a bond NH O NH Q3f OH 3113 N O Q1m a bond Me abond NH S a bond Q3a OH 3114 N O Q1m a bond Me a bond NH S a bond Q3d OH3115 N O Q1m a bond Me a bond NH S a bond Q3e OH 3116 N O Q1m a bond Mea bond NH S a bond Q3f OH 3117 N O Q1m a bond Me a bond NH S NH Q3a OH3118 N O Q1m a bond Me a bond NH S NH Q3d OH 3119 N O Q1m a bond Me abond NH S NH Q3e OH 3120 N O Q1m a bond Me a bond NH S NH Q3f OH 3121 NO Q1n a bond Me a bond NH O a bond Q3a OH 3122 N O Q1n a bond Me a bondNH O a bond Q3d OH 3123 N O Q1n a bond Me a bond NH O a bond Q3e OH 3124N O Q1n a bond Me a bond NH O a bond Q3f OH 3125 N O Q1n a bond Me abond NH O NH Q3a OH 3126 N O Q1n a bond Me a bond NH O NH Q3d OH 3127 NO Q1n a bond Me a bond NH O NH Q3e OH 3128 N O Q1n a bond Me a bond NH ONH Q3f OH 3129 N O Q1n a bond Me a bond NH S a bond Q3a OH 3130 N O Q1na bond Me a bond NH S a bond Q3d OH 3131 N O Q1n a bond Me a bond NH S abond Q3e OH 3132 N O Q1n a bond Me a bond NH S a bond Q3f OH 3133 N OQ1n a bond Me a bond NH S NH Q3a OH 3134 N O Q1n a bond Me a bond NH SNH Q3d OH 3135 N O Q1n a bond Me a bond NH S NH Q3e OH 3136 N O Q1n abond Me a bond NH S NH Q3f OH 3137 CH NMe Q1k a bond Me a bond NH O abond Q3a OH 3138 CH NMe Q1k a bond Me a bond NH O a bond Q3d OH 3139 CHNMe Q1k a bond Me a bond NH O a bond Q3e OH 3140 CH NMe Q1k a bond Me abond NH O a bond Q3f OH 3141 CH NMe Q1k a bond Me a bond NH O NH Q3a OH3142 CH NMe Q1k a bond Me a bond NH O NH Q3d OH 3143 CH NMe Q1k a bondMe a bond NH O NH Q3e OH 3144 CH NMe Q1k a bond Me a bond NH O NH Q3f OH3145 CH NMe Q1k a bond Me a bond NH S a bond Q3a OH 3146 CH NMe Q1k abond Me a bond NH S a bond Q3d OH 3147 CH NMe Q1k a bond Me a bond NH Sa bond Q3e OH 3148 CH NMe Q1k a bond Me a bond NH S a bond Q3f OH 3149CH NMe Q1k a bond Me a bond NH S NH Q3a OH 3150 CH NMe Q1k a bond Me abond NH S NH Q3d OH 3151 CH NMe Q1k a bond Me a bond NH S NH Q3e OH 3152CH NMe Q1k a bond Me a bond NH S NH Q3f OH 3153 CH NMe Q1l a bond Me abond NH O a bond Q3a OH 3154 CH NMe Q1l a bond Me a bond NH O a bond Q3dOH 3155 CH NMe Q1l a bond Me a bond NH O a bond Q3e OH 3156 CH NMe Q1l abond Me a bond NH O a bond Q3f OH 3157 CH NMe Q1l a bond Me a bond NH ONH Q3a OH 3158 CH NMe Q1l a bond Me a bond NH O NH Q3d OH 3159 CH NMeQ1l a bond Me a bond NH O NH Q3e OH 3160 CH NMe Q1l a bond Me a bond NHO NH Q3f OH 3161 CH NMe Q1l a bond Me a bond NH S a bond Q3a OH 3162 CHNMe Q1l a bond Me a bond NH S a bond Q3d OH 3163 CH NMe Q1l a bond Me abond NH S a bond Q3e OH 3164 CH NMe Q1l a bond Me a bond NH S a bond Q3fOH 3165 CH NMe Q1l a bond Me a bond NH S NH Q3a OH 3166 CH NMe Q1l abond Me a bond NH S NH Q3d OH 3167 CH NMe Q1l a bond Me a bond NH S NHQ3e OH 3168 CH NMe Q1l a bond Me a bond NH S NH Q3f OH 3169 CH NMe Q1m abond Me a bond NH O a bond Q3a OH 3170 CH NMe Q1m a bond Me a bond NH Oa bond Q3d OH 3171 CH NMe Q1m a bond Me a bond NH O a bond Q3e OH 3172CH NMe Q1m a bond Me a bond NH O a bond Q3f OH 3173 CH NMe Q1m a bond Mea bond NH O NH Q3a OH 3174 CH NMe Q1m a bond Me a bond NH O NH Q3d OH3175 CH NMe Q1m a bond Me a bond NH O NH Q3e OH 3176 CH NMe Q1m a bondMe a bond NH O NH Q3f OH 3177 CH NMe Q1m a bond Me a bond NH S a bondQ3a OH 3178 CH NMe Q1m a bond Me a bond NH S a bond Q3d OH 3179 CH NMeQ1m a bond Me a bond NH S a bond Q3e OH 3180 CH NMe Q1m a bond Me a bondNH S a bond Q3f OH 3181 CH NMe Q1m a bond Me a bond NH S NH Q3a OH 3182CH NMe Q1m a bond Me a bond NH S NH Q3d OH 3183 CH NMe Q1m a bond Me abond NH S NH Q3e OH 3184 CH NMe Q1m a bond Me a bond NH S NH Q3f OH 3185CH NMe Q1n a bond Me a bond NH O a bond Q3a OH 3186 CH NMe Q1n a bond Mea bond NH O a bond Q3d OH 3187 CH NMe Q1n a bond Me a bond NH O a bondQ3e OH 3188 CH NMe Q1n a bond Me a bond NH O a bond Q3f OH 3189 CH NMeQ1n a bond Me a bond NH O NH Q3a OH 3190 CH NMe Q1n a bond Me a bond NHO NH Q3d OH 3191 CH NMe Q1n a bond Me a bond NH O NH Q3e OH 3192 CH NMeQ1n a bond Me a bond NH O NH Q3f OH 3193 CH NMe Q1n a bond Me a bond NHS a bond Q3a OH 3194 CH NMe Q1n a bond Me a bond NH S a bond Q3d OH 3195CH NMe Q1n a bond Me a bond NH S a bond Q3e OH 3196 CH NMe Q1n a bond Mea bond NH S a bond Q3f OH 3197 CH NMe Q1n a bond Me a bond NH S NH Q3aOH 3198 CH NMe Q1n a bond Me a bond NH S NH Q3d OH 3199 CH NMe Q1n abond Me a bond NH S NH Q3e OH 3200 CH NMe Q1n a bond Me a bond NH S NHQ3f OH 3201 CH NEt Q1k a bond Me a bond NH O a bond Q3a OH 3202 CH NEtQ1k a bond Me a bond NH O a bond Q3d OH 3203 CH NEt Q1k a bond Me a bondNH O a bond Q3e OH 3204 CH NEt Q1k a bond Me a bond NH O a bond Q3f OH3205 CH NEt Q1k a bond Me a bond NH O NH Q3a OH 3206 CH NEt Q1k a bondMe a bond NH O NH Q3d OH 3207 CH NEt Q1k a bond Me a bond NH O NH Q3e OH3208 CH NEt Q1k a bond Me a bond NH O NH Q3f OH 3209 CH NEt Q1k a bondMe a bond NH S a bond Q3a OH 3210 CH NEt Q1k a bond Me a bond NH S abond Q3d OH 3211 CH NEt Q1k a bond Me a bond NH S a bond Q3e OH 3212 CHNEt Q1k a bond Me a bond NH S a bond Q3f OH 3213 CH NEt Q1k a bond Me abond NH S NH Q3a OH 3214 CH NEt Q1k a bond Me a bond NH S NH Q3d OH 3215CH NEt Q1k a bond Me a bond NH S NH Q3e OH 3216 CH NEt Q1k a bond Me abond NH S NH Q3f OH 3217 CH NEt Q1l a bond Me a bond NH O a bond Q3a OH3218 CH NEt Q1l a bond Me a bond NH O a bond Q3d OH 3219 CH NEt Q1l abond Me a bond NH O a bond Q3e OH 3220 CH NEt Q1l a bond Me a bond NH Oa bond Q3f OH 3221 CH NEt Q1l a bond Me a bond NH O NH Q3a OH 3222 CHNEt Q1l a bond Me a bond NH O NH Q3d OH 3223 CH NEt Q1l a bond Me a bondNH O NH Q3e OH 3224 CH NEt Q1l a bond Me a bond NH O NH Q3f OH 3225 CHNEt Q1l a bond Me a bond NH S a bond Q3a OH 3226 CH NEt Q1l a bond Me abond NH S a bond Q3d OH 3227 CH NEt Q1l a bond Me a bond NH S a bond Q3eOH 3228 CH NEt Q1l a bond Me a bond NH S a bond Q3f OH 3229 CH NEt Q1l abond Me a bond NH S NH Q3a OH 3230 CH NEt Q1l a bond Me a bond NH S NHQ3d OH 3231 CH NEt Q1l a bond Me a bond NH S NH Q3e OH 3232 CH NEt Q1l abond Me a bond NH S NH Q3f OH 3233 CH NEt Q1m a bond Me a bond NH O abond Q3a OH 3234 CH NEt Q1m a bond Me a bond NH O a bond Q3d OH 3235 CHNEt Q1m a bond Me a bond NH O a bond Q3e OH 3236 CH NEt Q1m a bond Me abond NH O a bond Q3f OH 3237 CH NEt Q1m a bond Me a bond NH O NH Q3a OH3238 CH NEt Q1m a bond Me a bond NH O NH Q3d OH 3239 CH NEt Q1m a bondMe a bond NH O NH Q3e OH 3240 CH NEt Q1m a bond Me a bond NH O NH Q3f OH3241 CH NEt Q1m a bond Me a bond NH S a bond Q3a OH 3242 CH NEt Q1m abond Me a bond NH S a bond Q3d OH 3243 CH NEt Q1m a bond Me a bond NH Sa bond Q3e OH 3244 CH NEt Q1m a bond Me a bond NH S a bond Q3f OH 3245CH NEt Q1m a bond Me a bond NH S NH Q3a OH 3246 CH NEt Q1m a bond Me abond NH S NH Q3d OH 3247 CH NEt Q1m a bond Me a bond NH S NH Q3e OH 3248CH NEt Q1m a bond Me a bond NH S NH Q3f OH 3249 CH NEt Q1n a bond Me abond NH O a bond Q3a OH 3250 CH NEt Q1n a bond Me a bond NH O a bond Q3dOH 3251 CH NEt Q1n a bond Me a bond NH O a bond Q3e OH 3252 CH NEt Q1n abond Me a bond NH O a bond Q3f OH 3253 CH NEt Q1n a bond Me a bond NH ONH Q3a OH 3254 CH NEt Q1n a bond Me a bond NH O NH Q3d OH 3255 CH NEtQ1n a bond Me a bond NH O NH Q3e OH 3256 CH NEt Q1n a bond Me a bond NHO NH Q3f OH 3257 CH NEt Q1n a bond Me a bond NH S a bond Q3a OH 3258 CHNEt Q1n a bond Me a bond NH S a bond Q3d OH 3259 CH NEt Q1n a bond Me abond NH S a bond Q3e OH 3260 CH NEt Q1n a bond Me a bond NH S a bond Q3fOH 3261 CH NEt Q1n a bond Me a bond NH S NH Q3a OH 3262 CH NEt Q1n abond Me a bond NH S NH Q3d OH 3263 CH NEt Q1n a bond Me a bond NH S NHQ3e OH 3264 CH NEt Q1n a bond Me a bond NH S NH Q3f OH 3265 CH S Q1k abond Me a bond NH O a bond Q3a OH 3266 CH S Q1k a bond Me a bond NH O abond Q3d OH 3267 CH S Q1k a bond Me a bond NH O a bond Q3e OH 3268 CH SQ1k a bond Me a bond NH O a bond Q3f OH 3269 CH S Q1k a bond Me a bondNH O NH Q3a OH 3270 CH S Q1k a bond Me a bond NH O NH Q3d OH 3271 CH SQ1k a bond Me a bond NH O NH Q3e OH 3272 CH S Q1k a bond Me a bond NH ONH Q3f OH 3273 CH S Q1k a bond Me a bond NH S a bond Q3a OH 3274 CH SQ1k a bond Me a bond NH S a bond Q3d OH 3275 CH S Q1k a bond Me a bondNH S a bond Q3e OH 3276 CH S Q1k a bond Me a bond NH S a bond Q3f OH3277 CH S Q1k a bond Me a bond NH S NH Q3a OH 3278 CH S Q1k a bond Me abond NH S NH Q3d OH 3279 CH S Q1k a bond Me a bond NH S NH Q3e OH 3280CH S Q1k a bond Me a bond NH S NH Q3f OH 3281 CH S Q1l a bond Me a bondNH O a bond Q3a OH 3282 CH S Q1l a bond Me a bond NH O a bond Q3d OH3283 CH S Q1l a bond Me a bond NH O a bond Q3e OH 3284 CH S Q1l a bondMe a bond NH O a bond Q3f OH 3285 CH S Q1l a bond Me a bond NH O NH Q3aOH 3286 CH S Q1l a bond Me a bond NH O NH Q3d OH 3287 CH S Q1l a bond Mea bond NH O NH Q3e OH 3288 CH S Q1l a bond Me a bond NH O NH Q3f OH 3289CH S Q1l a bond Me a bond NH S a bond Q3a OH 3290 CH S Q1l a bond Me abond NH S a bond Q3d OH 3291 CH S Q1l a bond Me a bond NH S a bond Q3eOH 3292 CH S Q1l a bond Me a bond NH S a bond Q3f OH 3293 CH S Q1l abond Me a bond NH S NH Q3a OH 3294 CH S Q1l a bond Me a bond NH S NH Q3dOH 3295 CH S Q1l a bond Me a bond NH S NH Q3e OH 3296 CH S Q1l a bond Mea bond NH S NH Q3f OH 3297 CH S Q1m a bond Me a bond NH O a bond Q3a OH3298 CH S Q1m a bond Me a bond NH O a bond Q3d OH 3299 CH S Q1m a bondMe a bond NH O a bond Q3e OH 3300 CH S Q1m a bond Me a bond NH O a bondQ3f OH 3301 CH S Q1m a bond Me a bond NH O NH Q3a OH 3302 CH S Q1m abond Me a bond NH O NH Q3d OH 3303 CH S Q1m a bond Me a bond NH O NH Q3eOH 3304 CH S Q1m a bond Me a bond NH O NH Q3f OH 3305 CH S Q1m a bond Mea bond NH S a bond Q3a OH 3306 CH S Q1m a bond Me a bond NH S a bond Q3dOH 3307 CH S Q1m a bond Me a bond NH S a bond Q3e OH 3308 CH S Q1m abond Me a bond NH S a bond Q3f OH 3309 CH S Q1m a bond Me a bond NH S NHQ3a OH 3310 CH S Q1m a bond Me a bond NH S NH Q3d OH 3311 CH S Q1m abond Me a bond NH S NH Q3e OH 3312 CH S Q1m a bond Me a bond NH S NH Q3fOH 3313 CH S Q1n a bond Me a bond NH O a bond Q3a OH 3314 CH S Q1n abond Me a bond NH O a bond Q3d OH 3315 CH S Q1n a bond Me a bond NH O abond Q3e OH 3316 CH S Q1n a bond Me a bond NH O a bond Q3f OH 3317 CH SQ1n a bond Me a bond NH O NH Q3a OH 3318 CH S Q1n a bond Me a bond NH ONH Q3d OH 3319 CH S Q1n a bond Me a bond NH O NH Q3e OH 3320 CH S Q1n abond Me a bond NH O NH Q3f OH 3321 CH S Q1n a bond Me a bond NH S a bondQ3a OH 3322 CH S Q1n a bond Me a bond NH S a bond Q3d OH 3323 CH S Q1n abond Me a bond NH S a bond Q3e OH 3324 CH S Q1n a bond Me a bond NH S abond Q3f OH 3325 CH S Q1n a bond Me a bond NH S NH Q3a OH 3326 CH S Q1na bond Me a bond NH S NH Q3d OH 3327 CH S Q1n a bond Me a bond NH S NHQ3e OH 3328 CH S Q1n a bond Me a bond NH S NH Q3f OH 3329 CH O Q1k abond Me a bond NH O a bond Q3a OH 3330 CH O Q1k a bond Me a bond NH O abond Q3d OH 3331 CH O Q1k a bond Me a bond NH O a bond Q3e OH 3332 CH OQ1k a bond Me a bond NH O a bond Q3f OH 3333 CH O Q1k a bond Me a bondNH O NH Q3a OH 3334 CH O Q1k a bond Me a bond NH O NH Q3d OH 3335 CH OQ1k a bond Me a bond NH O NH Q3e OH 3336 CH O Q1k a bond Me a bond NH ONH Q3f OH 3337 CH O Q1k a bond Me a bond NH S a bond Q3a OH 3338 CH OQ1k a bond Me a bond NH S a bond Q3d OH 3339 CH O Q1k a bond Me a bondNH S a bond Q3e OH 3340 CH O Q1k a bond Me a bond NH S a bond Q3f OH3341 CH O Q1k a bond Me a bond NH S NH Q3a OH 3342 CH O Q1k a bond Me abond NH S NH Q3d OH 3343 CH O Q1k a bond Me a bond NH S NH Q3e OH 3344CH O Q1k a bond Me a bond NH S NH Q3f OH 3345 CH O Q1l a bond Me a bondNH O a bond Q3a OH 3346 CH O Q1l a bond Me a bond NH O a bond Q3d OH3347 CH O Q1l a bond Me a bond NH O a bond Q3e OH 3348 CH O Q1l a bondMe a bond NH O a bond Q3f OH 3349 CH O Q1l a bond Me a bond NH O NH Q3aOH 3350 CH O Q1l a bond Me a bond NH O NH Q3d OH 3351 CH O Q1l a bond Mea bond NH O NH Q3e OH 3352 CH O Q1l a bond Me a bond NH O NH Q3f OH 3353CH O Q1l a bond Me a bond NH S a bond Q3a OH 3354 CH O Q1l a bond Me abond NH S a bond Q3d OH 3355 CH O Q1l a bond Me a bond NH S a bond Q3eOH 3356 CH O Q1l a bond Me a bond NH S a bond Q3f OH 3357 CH O Q1l abond Me a bond NH S NH Q3a OH 3358 CH O Q1l a bond Me a bond NH S NH Q3dOH 3359 CH O Q1l a bond Me a bond NH S NH Q3e OH 3360 CH O Q1l a bond Mea bond NH S NH Q3f OH 3361 CH O Q1m a bond Me a bond NH O a bond Q3a OH3362 CH O Q1m a bond Me a bond NH O a bond Q3d OH 3363 CH O Q1m a bondMe a bond NH O a bond Q3e OH 3364 CH O Q1m a bond Me a bond NH O a bondQ3f OH 3365 CH O Q1m a bond Me a bond NH O NH Q3a OH 3366 CH O Q1m abond Me a bond NH O NH Q3d OH 3367 CH O Q1m a bond Me a bond NH O NH Q3eOH 3368 CH O Q1m a bond Me a bond NH O NH Q3f OH 3369 CH O Q1m a bond Mea bond NH S a bond Q3a OH 3370 CH O Q1m a bond Me a bond NH S a bond Q3dOH 3371 CH O Q1m a bond Me a bond NH S a bond Q3e OH 3372 CH O Q1m abond Me a bond NH S a bond Q3f OH 3373 CH O Q1m a bond Me a bond NH S NHQ3a OH 3374 CH O Q1m a bond Me a bond NH S NH Q3d OH 3375 CH O Q1m abond Me a bond NH S NH Q3e OH 3376 CH O Q1m a bond Me a bond NH S NH Q3fOH 3377 CH O Q1n a bond Me a bond NH O a bond Q3a OH 3378 CH O Q1n abond Me a bond NH O a bond Q3d OH 3379 CH O Q1n a bond Me a bond NH O abond Q3e OH 3380 CH O Q1n a bond Me a bond NH O a bond Q3f OH 3381 CH OQ1n a bond Me a bond NH O NH Q3a OH 3382 CH O Q1n a bond Me a bond NH ONH Q3d OH 3383 CH O Q1n a bond Me a bond NH O NH Q3e OH 3384 CH O Q1n abond Me a bond NH O NH Q3f OH 3385 CH O Q1n a bond Me a bond NH S a bondQ3a OH 3386 CH O Q1n a bond Me a bond NH S a bond Q3d OH 3387 CH O Q1n abond Me a bond NH S a bond Q3e OH 3388 CH O Q1n a bond Me a bond NH S abond Q3f OH 3389 CH O Q1n a bond Me a bond NH S NH Q3a OH 3390 CH O Q1na bond Me a bond NH S NH Q3d OH 3391 CH O Q1n a bond Me a bond NH S NHQ3e OH 3392 CH O Q1n a bond Me a bond NH S NH Q3f OH 3393 CMe NMe Q1k abond Me a bond NH O a bond Q3a OH 3394 CMe NMe Q1k a bond Me a bond NH Oa bond Q3d OH 3395 CMe NMe Q1k a bond Me a bond NH O a bond Q3e OH 3396CMe NMe Q1k a bond Me a bond NH O a bond Q3f OH 3397 CMe NMe Q1k a bondMe a bond NH O NH Q3a OH 3398 CMe NMe Q1k a bond Me a bond NH O NH Q3dOH 3399 CMe NMe Q1k a bond Me a bond NH O NH Q3e OH 3400 CMe NMe Q1k abond Me a bond NH O NH Q3f OH 3401 CMe NMe Q1k a bond Me a bond NH S abond Q3a OH 3402 CMe NMe Q1k a bond Me a bond NH S a bond Q3d OH 3403CMe NMe Q1k a bond Me a bond NH S a bond Q3e OH 3404 CMe NMe Q1k a bondMe a bond NH S a bond Q3f OH 3405 CMe NMe Q1k a bond Me a bond NH S NHQ3a OH 3406 CMe NMe Q1k a bond Me a bond NH S NH Q3d OH 3407 CMe NMe Q1ka bond Me a bond NH S NH Q3e OH 3408 CMe NMe Q1k a bond Me a bond NH SNH Q3f OH 3409 CMe NMe Q1l a bond Me a bond NH O a bond Q3a OH 3410 CMeNMe Q1l a bond Me a bond NH O a bond Q3d OH 3411 CMe NMe Q1l a bond Me abond NH O a bond Q3e OH 3412 CMe NMe Q1l a bond Me a bond NH O a bondQ3f OH 3413 CMe NMe Q1l a bond Me a bond NH O NH Q3a OH 3414 CMe NMe Q1la bond Me a bond NH O NH Q3d OH 3415 CMe NMe Q1l a bond Me a bond NH ONH Q3e OH 3416 CMe NMe Q1l a bond Me a bond NH O NH Q3f OH 3417 CMe NMeQ1l a bond Me a bond NH S a bond Q3a OH 3418 CMe NMe Q1l a bond Me abond NH S a bond Q3d OH 3419 CMe NMe Q1l a bond Me a bond NH S a bondQ3e OH 3420 CMe NMe Q1l a bond Me a bond NH S a bond Q3f OH 3421 CMe NMeQ1l a bond Me a bond NH S NH Q3a OH 3422 CMe NMe Q1l a bond Me a bond NHS NH Q3d OH 3423 CMe NMe Q1l a bond Me a bond NH S NH Q3e OH 3424 CMeNMe Q1l a bond Me a bond NH S NH Q3f OH 3425 CMe NMe Q1m a bond Me abond NH O a bond Q3a OH 3426 CMe NMe Q1m a bond Me a bond NH O a bondQ3d OH 3427 CMe NMe Q1m a bond Me a bond NH O a bond Q3e OH 3428 CMe NMeQ1m a bond Me a bond NH O a bond Q3f OH 3429 CMe NMe Q1m a bond Me abond NH O NH Q3a OH 3430 CMe NMe Q1m a bond Me a bond NH O NH Q3d OH3431 CMe NMe Q1m a bond Me a bond NH O NH Q3e OH 3432 CMe NMe Q1m a bondMe a bond NH O NH Q3f OH 3433 CMe NMe Q1m a bond Me a bond NH S a bondQ3a OH 3434 CMe NMe Q1m a bond Me a bond NH S a bond Q3d OH 3435 CMe NMeQ1m a bond Me a bond NH S a bond Q3e OH 3436 CMe NMe Q1m a bond Me abond NH S a bond Q3f OH 3437 CMe NMe Q1m a bond Me a bond NH S NH Q3a OH3438 CMe NMe Q1m a bond Me a bond NH S NH Q3d OH 3439 CMe NMe Q1m a bondMe a bond NH S NH Q3e OH 3440 CMe NMe Q1m a bond Me a bond NH S NH Q3fOH 3441 CMe NMe Q1n a bond Me a bond NH O a bond Q3a OH 3442 CMe NMe Q1na bond Me a bond NH O a bond Q3d OH 3443 CMe NMe Q1n a bond Me a bond NHO a bond Q3e OH 3444 CMe NMe Q1n a bond Me a bond NH O a bond Q3f OH3445 CMe NMe Q1n a bond Me a bond NH O NH Q3a OH 3446 CMe NMe Q1n a bondMe a bond NH O NH Q3d OH 3447 CMe NMe Q1n a bond Me a bond NH O NH Q3eOH 3448 CMe NMe Q1n a bond Me a bond NH O NH Q3f OH 3449 CMe NMe Q1n abond Me a bond NH S a bond Q3a OH 3450 CMe NMe Q1n a bond Me a bond NH Sa bond Q3d OH 3451 CMe NMe Q1n a bond Me a bond NH S a bond Q3e OH 3452CMe NMe Q1n a bond Me a bond NH S a bond Q3f OH 3453 CMe NMe Q1n a bondMe a bond NH S NH Q3a OH 3454 CMe NMe Q1n a bond Me a bond NH S NH Q3dOH 3455 CMe NMe Q1n a bond Me a bond NH S NH Q3e OH 3456 CMe NMe Q1n abond Me a bond NH S NH Q3f OH 3457 CMe NEt Q1k a bond Me a bond NH O abond Q3a OH 3458 CMe NEt Q1k a bond Me a bond NH O a bond Q3d OH 3459CMe NEt Q1k a bond Me a bond NH O a bond Q3e OH 3460 CMe NEt Q1k a bondMe a bond NH O a bond Q3f OH 3461 CMe NEt Q1k a bond Me a bond NH O NHQ3a OH 3462 CMe NEt Q1k a bond Me a bond NH O NH Q3d OH 3463 CMe NEt Q1ka bond Me a bond NH O NH Q3e OH 3464 CMe NEt Q1k a bond Me a bond NH ONH Q3f OH 3465 CMe NEt Q1k a bond Me a bond NH S a bond Q3a OH 3466 CMeNEt Q1k a bond Me a bond NH S a bond Q3d OH 3467 CMe NEt Q1k a bond Me abond NH S a bond Q3e OH 3468 CMe NEt Q1k a bond Me a bond NH S a bondQ3f OH 3469 CMe NEt Q1k a bond Me a bond NH S NH Q3a OH 3470 CMe NEt Q1ka bond Me a bond NH S NH Q3d OH 3471 CMe NEt Q1k a bond Me a bond NH SNH Q3e OH 3472 CMe NEt Q1k a bond Me a bond NH S NH Q3f OH 3473 CMe NEtQ1l a bond Me a bond NH O a bond Q3a OH 3474 CMe NEt Q1l a bond Me abond NH O a bond Q3d OH 3475 CMe NEt Q1l a bond Me a bond NH O a bondQ3e OH 3476 CMe NEt Q1l a bond Me a bond NH O a bond Q3f OH 3477 CMe NEtQ1l a bond Me a bond NH O NH Q3a OH 3478 CMe NEt Q1l a bond Me a bond NHO NH Q3d OH 3479 CMe NEt Q1l a bond Me a bond NH O NH Q3e OH 3480 CMeNEt Q1l a bond Me a bond NH O NH Q3f OH 3481 CMe NEt Q1l a bond Me abond NH S a bond Q3a OH 3482 CMe NEt Q1l a bond Me a bond NH S a bondQ3d OH 3483 CMe NEt Q1l a bond Me a bond NH S a bond Q3e OH 3484 CMe NEtQ1l a bond Me a bond NH S a bond Q3f OH 3485 CMe NEt Q1l a bond Me abond NH S NH Q3a OH 3486 CMe NEt Q1l a bond Me a bond NH S NH Q3d OH3487 CMe NEt Q1l a bond Me a bond NH S NH Q3e OH 3488 CMe NEt Q1l a bondMe a bond NH S NH Q3f OH 3489 CMe NEt Q1m a bond Me a bond NH O a bondQ3a OH 3490 CMe NEt Q1m a bond Me a bond NH O a bond Q3d OH 3491 CMe NEtQ1m a bond Me a bond NH O a bond Q3e OH 3492 CMe NEt Q1m a bond Me abond NH O a bond Q3f OH 3493 CMe NEt Q1m a bond Me a bond NH O NH Q3a OH3494 CMe NEt Q1m a bond Me a bond NH O NH Q3d OH 3495 CMe NEt Q1m a bondMe a bond NH O NH Q3e OH 3496 CMe NEt Q1m a bond Me a bond NH O NH Q3fOH 3497 CMe NEt Q1m a bond Me a bond NH S a bond Q3a OH 3498 CMe NEt Q1ma bond Me a bond NH S a bond Q3d OH 3499 CMe NEt Q1m a bond Me a bond NHS a bond Q3e OH 3500 CMe NEt Q1m a bond Me a bond NH S a bond Q3f OH3501 CMe NEt Q1m a bond Me a bond NH S NH Q3a OH 3502 CMe NEt Q1m a bondMe a bond NH S NH Q3d OH 3503 CMe NEt Q1m a bond Me a bond NH S NH Q3eOH 3504 CMe NEt Q1m a bond Me a bond NH S NH Q3f OH 3505 CMe NEt Q1n abond Me a bond NH O a bond Q3a OH 3506 CMe NEt Q1n a bond Me a bond NH Oa bond Q3d OH 3507 CMe NEt Q1n a bond Me a bond NH O a bond Q3e OH 3508CMe NEt Q1n a bond Me a bond NH O a bond Q3f OH 3509 CMe NEt Q1n a bondMe a bond NH O NH Q3a OH 3510 CMe NEt Q1n a bond Me a bond NH O NH Q3dOH 3511 CMe NEt Q1n a bond Me a bond NH O NH Q3e OH 3512 CMe NEt Q1n abond Me a bond NH O NH Q3f OH 3513 CMe NEt Q1n a bond Me a bond NH S abond Q3a OH 3514 CMe NEt Q1n a bond Me a bond NH S a bond Q3d OH 3515CMe NEt Q1n a bond Me a bond NH S a bond Q3e OH 3516 CMe NEt Q1n a bondMe a bond NH S a bond Q3f OH 3517 CMe NEt Q1n a bond Me a bond NH S NHQ3a OH 3518 CMe NEt Q1n a bond Me a bond NH S NH Q3d OH 3519 CMe NEt Q1na bond Me a bond NH S NH Q3e OH 3520 CMe NEt Q1n a bond Me a bond NH SNH Q3f OH 3521 CMe S Q1k a bond Me a bond NH O a bond Q3a OH 3522 CMe SQ1k a bond Me a bond NH O a bond Q3d OH 3523 CMe S Q1k a bond Me a bondNH O a bond Q3e OH 3524 CMe S Q1k a bond Me a bond NH O a bond Q3f OH3525 CMe S Q1k a bond Me a bond NH O NH Q3a OH 3526 CMe S Q1k a bond Mea bond NH O NH Q3d OH 3527 CMe S Q1k a bond Me a bond NH O NH Q3e OH3528 CMe S Q1k a bond Me a bond NH O NH Q3f OH 3529 CMe S Q1k a bond Mea bond NH S a bond Q3a OH 3530 CMe S Q1k a bond Me a bond NH S a bondQ3d OH 3531 CMe S Q1k a bond Me a bond NH S a bond Q3e OH 3532 CMe S Q1ka bond Me a bond NH S a bond Q3f OH 3533 CMe S Q1k a bond Me a bond NH SNH Q3a OH 3534 CMe S Q1k a bond Me a bond NH S NH Q3d OH 3535 CMe S Q1ka bond Me a bond NH S NH Q3e OH 3536 CMe S Q1k a bond Me a bond NH S NHQ3f OH 3537 CMe S Q1l a bond Me a bond NH O a bond Q3a OH 3538 CMe S Q1la bond Me a bond NH O a bond Q3d OH 3539 CMe S Q1l a bond Me a bond NH Oa bond Q3e OH 3540 CMe S Q1l a bond Me a bond NH O a bond Q3f OH 3541CMe S Q1l a bond Me a bond NH O NH Q3a OH 3542 CMe S Q1l a bond Me abond NH O NH Q3d OH 3543 CMe S Q1l a bond Me a bond NH O NH Q3e OH 3544CMe S Q1l a bond Me a bond NH O NH Q3f OH 3545 CMe S Q1l a bond Me abond NH S a bond Q3a OH 3546 CMe S Q1l a bond Me a bond NH S a bond Q3dOH 3547 CMe S Q1l a bond Me a bond NH S a bond Q3e OH 3548 CMe S Q1l abond Me a bond NH S a bond Q3f OH 3549 CMe S Q1l a bond Me a bond NH SNH Q3a OH 3550 CMe S Q1l a bond Me a bond NH S NH Q3d OH 3551 CMe S Q1la bond Me a bond NH S NH Q3e OH 3552 CMe S Q1l a bond Me a bond NH S NHQ3f OH 3553 CMe S Q1m a bond Me a bond NH O a bond Q3a OH 3554 CMe S Q1ma bond Me a bond NH O a bond Q3d OH 3555 CMe S Q1m a bond Me a bond NH Oa bond Q3e OH 3556 CMe S Q1m a bond Me a bond NH O a bond Q3f OH 3557CMe S Q1m a bond Me a bond NH O NH Q3a OH 3558 CMe S Q1m a bond Me abond NH O NH Q3d OH 3559 CMe S Q1m a bond Me a bond NH O NH Q3e OH 3560CMe S Q1m a bond Me a bond NH O NH Q3f OH 3561 CMe S Q1m a bond Me abond NH S a bond Q3a OH 3562 CMe S Q1m a bond Me a bond NH S a bond Q3dOH 3563 CMe S Q1m a bond Me a bond NH S a bond Q3e OH 3564 CMe S Q1m abond Me a bond NH S a bond Q3f OH 3565 CMe S Q1m a bond Me a bond NH SNH Q3a OH 3566 CMe S Q1m a bond Me a bond NH S NH Q3d OH 3567 CMe S Q1ma bond Me a bond NH S NH Q3e OH 3568 CMe S Q1m a bond Me a bond NH S NHQ3f OH 3569 CMe S Q1n a bond Me a bond NH O a bond Q3a OH 3570 CMe S Q1na bond Me a bond NH O a bond Q3d OH 3571 CMe S Q1n a bond Me a bond NH Oa bond Q3e OH 3572 CMe S Q1n a bond Me a bond NH O a bond Q3f OH 3573CMe S Q1n a bond Me a bond NH O NH Q3a OH 3574 CMe S Q1n a bond Me abond NH O NH Q3d OH 3575 CMe S Q1n a bond Me a bond NH O NH Q3e OH 3576CMe S Q1n a bond Me a bond NH O NH Q3f OH 3577 CMe S Q1n a bond Me abond NH S a bond Q3a OH 3578 CMe S Q1n a bond Me a bond NH S a bond Q3dOH 3579 CMe S Q1n a bond Me a bond NH S a bond Q3e OH 3580 CMe S Q1n abond Me a bond NH S a bond Q3f OH 3581 CMe S Q1n a bond Me a bond NH SNH Q3a OH 3582 CMe S Q1n a bond Me a bond NH S NH Q3d OH 3583 CMe S Q1na bond Me a bond NH S NH Q3e OH 3584 CMe S Q1n a bond Me a bond NH S NHQ3f OH 3585 CMe O Q1k a bond Me a bond NH O a bond Q3a OH 3586 CMe O Q1ka bond Me a bond NH O a bond Q3d OH 3587 CMe O Q1k a bond Me a bond NH Oa bond Q3e OH 3588 CMe O Q1k a bond Me a bond NH O a bond Q3f OH 3589CMe O Q1k a bond Me a bond NH O NH Q3a OH 3590 CMe O Q1k a bond Me abond NH O NH Q3d OH 3591 CMe O Q1k a bond Me a bond NH O NH Q3e OH 3592CMe O Q1k a bond Me a bond NH O NH Q3f OH 3593 CMe O Q1k a bond Me abond NH S a bond Q3a OH 3594 CMe O Q1k a bond Me a bond NH S a bond Q3dOH 3595 CMe O Q1k a bond Me a bond NH S a bond Q3e OH 3596 CMe O Q1k abond Me a bond NH S a bond Q3f OH 3597 CMe O Q1k a bond Me a bond NH SNH Q3a OH 3598 CMe O Q1k a bond Me a bond NH S NH Q3d OH 3599 CMe O Q1ka bond Me a bond NH S NH Q3e OH 3600 CMe O Q1k a bond Me a bond NH S NHQ3f OH 3601 CMe O Q1l a bond Me a bond NH O a bond Q3a OH 3602 CMe O Q1la bond Me a bond NH O a bond Q3d OH 3603 CMe O Q1l a bond Me a bond NH Oa bond Q3e OH 3604 CMe O Q1l a bond Me a bond NH O a bond Q3f OH 3605CMe O Q1l a bond Me a bond NH O NH Q3a OH 3606 CMe O Q1l a bond Me abond NH O NH Q3d OH 3607 CMe O Q1l a bond Me a bond NH O NH Q3e OH 3608CMe O Q1l a bond Me a bond NH O NH Q3f OH 3609 CMe O Q1l a bond Me abond NH S a bond Q3a OH 3610 CMe O Q1l a bond Me a bond NH S a bond Q3dOH 3611 CMe O Q1l a bond Me a bond NH S a bond Q3e OH 3612 CMe O Q1l abond Me a bond NH S a bond Q3f OH 3613 CMe O Q1l a bond Me a bond NH SNH Q3a OH 3614 CMe O Q1l a bond Me a bond NH S NH Q3d OH 3615 CMe O Q1la bond Me a bond NH S NH Q3e OH 3616 CMe O Q1l a bond Me a bond NH S NHQ3f OH 3617 CMe O Q1m a bond Me a bond NH O a bond Q3a OH 3618 CMe O Q1ma bond Me a bond NH O a bond Q3d OH 3619 CMe O Q1m a bond Me a bond NH Oa bond Q3e OH 3620 CMe O Q1m a bond Me a bond NH O a bond Q3f OH 3621CMe O Q1m a bond Me a bond NH O NH Q3a OH 3622 CMe O Q1m a bond Me abond NH O NH Q3d OH 3623 CMe O Q1m a bond Me a bond NH O NH Q3e OH 3624CMe O Q1m a bond Me a bond NH O NH Q3f OH 3625 CMe O Q1m a bond Me abond NH S a bond Q3a OH 3626 CMe O Q1m a bond Me a bond NH S a bond Q3dOH 3627 CMe O Q1m a bond Me a bond NH S a bond Q3e OH 3628 CMe O Q1m abond Me a bond NH S a bond Q3f OH 3629 CMe O Q1m a bond Me a bond NH SNH Q3a OH 3630 CMe O Q1m a bond Me a bond NH S NH Q3d OH 3631 CMe O Q1ma bond Me a bond NH S NH Q3e OH 3632 CMe O Q1m a bond Me a bond NH S NHQ3f OH 3633 CMe O Q1n a bond Me a bond NH O a bond Q3a OH 3634 CMe O Q1na bond Me a bond NH O a bond Q3d OH 3635 CMe O Q1n a bond Me a bond NH Oa bond Q3e OH 3636 CMe O Q1n a bond Me a bond NH O a bond Q3f OH 3637CMe O Q1n a bond Me a bond NH O NH Q3a OH 3638 CMe O Q1n a bond Me abond NH O NH Q3d OH 3639 CMe O Q1n a bond Me a bond NH O NH Q3e OH 3640CMe O Q1n a bond Me a bond NH O NH Q3f OH 3641 CMe O Q1n a bond Me abond NH S a bond Q3a OH 3642 CMe O Q1n a bond Me a bond NH S a bond Q3dOH 3643 CMe O Q1n a bond Me a bond NH S a bond Q3e OH 3644 CMe O Q1n abond Me a bond NH S a bond Q3f OH 3645 CMe O Q1n a bond Me a bond NH SNH Q3a OH 3646 CMe O Q1n a bond Me a bond NH S NH Q3d OH 3647 CMe O Q1na bond Me a bond NH S NH Q3e OH 3648 CMe O Q1n a bond Me a bond NH S NHQ3f OH 3649 N NMe Q1k′ a bond Me a bond NH O a bond Q3a OH 3650 N NMeQ1k′ a bond Me a bond NH O a bond Q3d OH 3651 N NMe Q1k′ a bond Me abond NH O a bond Q3e OH 3652 N NMe Q1k′ a bond Me a bond NH O a bond Q3fOH 3653 N NMe Q1k′ a bond Me a bond NH O NH Q3a OH 3654 N NMe Q1k′ abond Me a bond NH O NH Q3d OH 3655 N NMe Q1k′ a bond Me a bond NH O NHQ3e OH 3656 N NMe Q1k′ a bond Me a bond NH O NH Q3f OH 3657 N NMe Q1k′ abond Me a bond NH S a bond Q3a OH 3658 N NMe Q1k′ a bond Me a bond NH Sa bond Q3d OH 3659 N NMe Q1k′ a bond Me a bond NH S a bond Q3e OH 3660 NNMe Q1k′ a bond Me a bond NH S a bond Q3f OH 3661 N NMe Q1k′ a bond Me abond NH S NH Q3a OH 3662 N NMe Q1k′ a bond Me a bond NH S NH Q3d OH 3663N NMe Q1k′ a bond Me a bond NH S NH Q3e OH 3664 N NMe Q1k′ a bond Me abond NH S NH Q3f OH 3665 N NMe Q1l′ a bond Me a bond NH O a bond Q3a OH3666 N NMe Q1l′ a bond Me a bond NH O a bond Q3d OH 3667 N NMe Q1l′ abond Me a bond NH O a bond Q3e OH 3668 N NMe Q1l′ a bond Me a bond NH Oa bond Q3f OH 3669 N NMe Q1l′ a bond Me a bond NH O NH Q3a OH 3670 N NMeQ1l′ a bond Me a bond NH O NH Q3d OH 3671 N NMe Q1l′ a bond Me a bond NHO NH Q3e OH 3672 N NMe Q1l′ a bond Me a bond NH O NH Q3f OH 3673 N NMeQ1l′ a bond Me a bond NH S a bond Q3a OH 3674 N NMe Q1l′ a bond Me abond NH S a bond Q3d OH 3675 N NMe Q1l′ a bond Me a bond NH S a bond Q3eOH 3676 N NMe Q1l′ a bond Me a bond NH S a bond Q3f OH 3677 N NMe Q1l′ abond Me a bond NH S NH Q3a OH 3678 N NMe Q1l′ a bond Me a bond NH S NHQ3d OH 3679 N NMe Q1l′ a bond Me a bond NH S NH Q3e OH 3680 N NMe Q1l′ abond Me a bond NH S NH Q3f OH 3681 N NMe Q1m′ a bond Me a bond NH O abond Q3a OH 3682 N NMe Q1m′ a bond Me a bond NH O a bond Q3d OH 3683 NNMe Q1m′ a bond Me a bond NH O a bond Q3e OH 3684 N NMe Q1m′ a bond Me abond NH O a bond Q3f OH 3685 N NMe Q1m′ a bond Me a bond NH O NH Q3a OH3686 N NMe Q1m′ a bond Me a bond NH O NH Q3d OH 3687 N NMe Q1m′ a bondMe a bond NH O NH Q3e OH 3688 N NMe Q1m′ a bond Me a bond NH O NH Q3f OH3689 N NMe Q1m′ a bond Me a bond NH S a bond Q3a OH 3690 N NMe Q1m′ abond Me a bond NH S a bond Q3d OH 3691 N NMe Q1m′ a bond Me a bond NH Sa bond Q3e OH 3692 N NMe Q1m′ a bond Me a bond NH S a bond Q3f OH 3693 NNMe Q1m′ a bond Me a bond NH S NH Q3a OH 3694 N NMe Q1m′ a bond Me abond NH S NH Q3d OH 3695 N NMe Q1m′ a bond Me a bond NH S NH Q3e OH 3696N NMe Q1m′ a bond Me a bond NH S NH Q3f OH 3697 N NMe Q1n′ a bond Me abond NH O a bond Q3a OH 3698 N NMe Q1n′ a bond Me a bond NH O a bond Q3dOH 3699 N NMe Q1n′ a bond Me a bond NH O a bond Q3e OH 3700 N NMe Q1n′ abond Me a bond NH O a bond Q3f OH 3701 N NMe Q1n′ a bond Me a bond NH ONH Q3a OH 3702 N NMe Q1n′ a bond Me a bond NH O NH Q3d OH 3703 N NMeQ1n′ a bond Me a bond NH O NH Q3e OH 3704 N NMe Q1n′ a bond Me a bond NHO NH Q3f OH 3705 N NMe Q1n′ a bond Me a bond NH S a bond Q3a OH 3706 NNMe Q1n′ a bond Me a bond NH S a bond Q3d OH 3707 N NMe Q1n′ a bond Me abond NH S a bond Q3e OH 3708 N NMe Q1n′ a bond Me a bond NH S a bond Q3fOH 3709 N NMe Q1n′ a bond Me a bond NH S NH Q3a OH 3710 N NMe Q1n′ abond Me a bond NH S NH Q3d OH 3711 N NMe Q1n′ a bond Me a bond NH S NHQ3e OH 3712 N NMe Q1n′ a bond Me a bond NH S NH Q3f OH 3713 N NEt Q1k′ abond Me a bond NH O a bond Q3a OH 3714 N NEt Q1k′ a bond Me a bond NH Oa bond Q3d OH 3715 N NEt Q1k′ a bond Me a bond NH O a bond Q3e OH 3716 NNEt Q1k′ a bond Me a bond NH O a bond Q3f OH 3717 N NEt Q1k′ a bond Me abond NH O NH Q3a OH 3718 N NEt Q1k′ a bond Me a bond NH O NH Q3d OH 3719N NEt Q1k′ a bond Me a bond NH O NH Q3e OH 3720 N NEt Q1k′ a bond Me abond NH O NH Q3f OH 3721 N NEt Q1k′ a bond Me a bond NH S a bond Q3a OH3722 N NEt Q1k′ a bond Me a bond NH S a bond Q3d OH 3723 N NEt Q1k′ abond Me a bond NH S a bond Q3e OH 3724 N NEt Q1k′ a bond Me a bond NH Sa bond Q3f OH 3725 N NEt Q1k′ a bond Me a bond NH S NH Q3a OH 3726 N NEtQ1k′ a bond Me a bond NH S NH Q3d OH 3727 N NEt Q1k′ a bond Me a bond NHS NH Q3e OH 3728 N NEt Q1k′ a bond Me a bond NH S NH Q3f OH 3729 N NEtQ1l′ a bond Me a bond NH O a bond Q3a OH 3730 N NEt Q1l′ a bond Me abond NH O a bond Q3d OH 3731 N NEt Q1l′ a bond Me a bond NH O a bond Q3eOH 3732 N NEt Q1l′ a bond Me a bond NH O a bond Q3f OH 3733 N NEt Q1l′ abond Me a bond NH O NH Q3a OH 3734 N NEt Q1l′ a bond Me a bond NH O NHQ3d OH 3735 N NEt Q1l′ a bond Me a bond NH O NH Q3e OH 3736 N NEt Q1l′ abond Me a bond NH O NH Q3f OH 3737 N NEt Q1l′ a bond Me a bond NH S abond Q3a OH 3738 N NEt Q1l′ a bond Me a bond NH S a bond Q3d OH 3739 NNEt Q1l′ a bond Me a bond NH S a bond Q3e OH 3740 N NEt Q1l′ a bond Me abond NH S a bond Q3f OH 3741 N NEt Q1l′ a bond Me a bond NH S NH Q3a OH3742 N NEt Q1l′ a bond Me a bond NH S NH Q3d OH 3743 N NEt Q1l′ a bondMe a bond NH S NH Q3e OH 3744 N NEt Q1l′ a bond Me a bond NH S NH Q3f OH3745 N NEt Q1m′ a bond Me a bond NH O a bond Q3a OH 3746 N NEt Q1m′ abond Me a bond NH O a bond Q3d OH 3747 N NEt Q1m′ a bond Me a bond NH Oa bond Q3e OH 3748 N NEt Q1m′ a bond Me a bond NH O a bond Q3f OH 3749 NNEt Q1m′ a bond Me a bond NH O NH Q3a OH 3750 N NEt Q1m′ a bond Me abond NH O NH Q3d OH 3751 N NEt Q1m′ a bond Me a bond NH O NH Q3e OH 3752N NEt Q1m′ a bond Me a bond NH O NH Q3f OH 3753 N NEt Q1m′ a bond Me abond NH S a bond Q3a OH 3754 N NEt Q1m′ a bond Me a bond NH S a bond Q3dOH 3755 N NEt Q1m′ a bond Me a bond NH S a bond Q3e OH 3756 N NEt Q1m′ abond Me a bond NH S a bond Q3f OH 3757 N NEt Q1m′ a bond Me a bond NH SNH Q3a OH 3758 N NEt Q1m′ a bond Me a bond NH S NH Q3d OH 3759 N NEtQ1m′ a bond Me a bond NH S NH Q3e OH 3760 N NEt Q1m′ a bond Me a bond NHS NH Q3f OH 3761 N NEt Q1n′ a bond Me a bond NH O a bond Q3a OH 3762 NNEt Q1n′ a bond Me a bond NH O a bond Q3d OH 3763 N NEt Q1n′ a bond Me abond NH O a bond Q3e OH 3764 N NEt Q1n′ a bond Me a bond NH O a bond Q3fOH 3765 N NEt Q1n′ a bond Me a bond NH O NH Q3a OH 3766 N NEt Q1n′ abond Me a bond NH O NH Q3d OH 3767 N NEt Q1n′ a bond Me a bond NH O NHQ3e OH 3768 N NEt Q1n′ a bond Me a bond NH O NH Q3f OH 3769 N NEt Q1n′ abond Me a bond NH S a bond Q3a OH 3770 N NEt Q1n′ a bond Me a bond NH Sa bond Q3d OH 3771 N NEt Q1n′ a bond Me a bond NH S a bond Q3e OH 3772 NNEt Q1n′ a bond Me a bond NH S a bond Q3f OH 3773 N NEt Q1n′ a bond Me abond NH S NH Q3a OH 3774 N NEt Q1n′ a bond Me a bond NH S NH Q3d OH 3775N NEt Q1n′ a bond Me a bond NH S NH Q3e OH 3776 N NEt Q1n′ a bond Me abond NH S NH Q3f OH 3777 N S Q1k′ a bond Me a bond NH O a bond Q3a OH3778 N S Q1k′ a bond Me a bond NH O a bond Q3d OH 3779 N S Q1k′ a bondMe a bond NH O a bond Q3e OH 3780 N S Q1k′ a bond Me a bond NH O a bondQ3f OH 3781 N S Q1k′ a bond Me a bond NH O NH Q3a OH 3782 N S Q1k′ abond Me a bond NH O NH Q3d OH 3783 N S Q1k′ a bond Me a bond NH O NH Q3eOH 3784 N S Q1k′ a bond Me a bond NH O NH Q3f OH 3785 N S Q1k′ a bond Mea bond NH S a bond Q3a OH 3786 N S Q1k′ a bond Me a bond NH S a bond Q3dOH 3787 N S Q1k′ a bond Me a bond NH S a bond Q3e OH 3788 N S Q1k′ abond Me a bond NH S a bond Q3f OH 3789 N S Q1k′ a bond Me a bond NH S NHQ3a OH 3790 N S Q1k′ a bond Me a bond NH S NH Q3d OH 3791 N S Q1k′ abond Me a bond NH S NH Q3e OH 3792 N S Q1k′ a bond Me a bond NH S NH Q3fOH 3793 N S Q1l′ a bond Me a bond NH O a bond Q3a OH 3794 N S Q1l′ abond Me a bond NH O a bond Q3d OH 3795 N S Q1l′ a bond Me a bond NH O abond Q3e OH 3796 N S Q1l′ a bond Me a bond NH O a bond Q3f OH 3797 N SQ1l′ a bond Me a bond NH O NH Q3a OH 3798 N S Q1l′ a bond Me a bond NH ONH Q3d OH 3799 N S Q1l′ a bond Me a bond NH O NH Q3e OH 3800 N S Q1l′ abond Me a bond NH O NH Q3f OH 3801 N S Q1l′ a bond Me a bond NH S a bondQ3a OH 3802 N S Q1l′ a bond Me a bond NH S a bond Q3d OH 3803 N S Q1l′ abond Me a bond NH S a bond Q3e OH 3804 N S Q1l′ a bond Me a bond NH S abond Q3f OH 3805 N S Q1l′ a bond Me a bond NH S NH Q3a OH 3806 N S Q1l′a bond Me a bond NH S NH Q3d OH 3807 N S Q1l′ a bond Me a bond NH S NHQ3e OH 3808 N S Q1l′ a bond Me a bond NH S NH Q3f OH 3809 N S Q1m′ abond Me a bond NH O a bond Q3a OH 3810 N S Q1m′ a bond Me a bond NH O abond Q3d OH 3811 N S Q1m′ a bond Me a bond NH O a bond Q3e OH 3812 N SQ1m′ a bond Me a bond NH O a bond Q3f OH 3813 N S Q1m′ a bond Me a bondNH O NH Q3a OH 3814 N S Q1m′ a bond Me a bond NH O NH Q3d OH 3815 N SQ1m′ a bond Me a bond NH O NH Q3e OH 3816 N S Q1m′ a bond Me a bond NH ONH Q3f OH 3817 N S Q1m′ a bond Me a bond NH S a bond Q3a OH 3818 N SQ1m′ a bond Me a bond NH S a bond Q3d OH 3819 N S Q1m′ a bond Me a bondNH S a bond Q3e OH 3820 N S Q1m′ a bond Me a bond NH S a bond Q3f OH3821 N S Q1m′ a bond Me a bond NH S NH Q3a OH 3822 N S Q1m′ a bond Me abond NH S NH Q3d OH 3823 N S Q1m′ a bond Me a bond NH S NH Q3e OH 3824 NS Q1m′ a bond Me a bond NH S NH Q3f OH 3825 N S Q1n′ a bond Me a bond NHO a bond Q3a OH 3826 N S Q1n′ a bond Me a bond NH O a bond Q3d OH 3827 NS Q1n′ a bond Me a bond NH O a bond Q3e OH 3828 N S Q1n′ a bond Me abond NH O a bond Q3f OH 3829 N S Q1n′ a bond Me a bond NH O NH Q3a OH3830 N S Q1n′ a bond Me a bond NH O NH Q3d OH 3831 N S Q1n′ a bond Me abond NH O NH Q3e OH 3832 N S Q1n′ a bond Me a bond NH O NH Q3f OH 3833 NS Q1n′ a bond Me a bond NH S a bond Q3a OH 3834 N S Q1n′ a bond Me abond NH S a bond Q3d OH 3835 N S Q1n′ a bond Me a bond NH S a bond Q3eOH 3836 N S Q1n′ a bond Me a bond NH S a bond Q3f OH 3837 N S Q1n′ abond Me a bond NH S NH Q3a OH 3838 N S Q1n′ a bond Me a bond NH S NH Q3dOH 3839 N S Q1n′ a bond Me a bond NH S NH Q3e OH 3840 N S Q1n′ a bond Mea bond NH S NH Q3f OH 3841 N O Q1k′ a bond Me a bond NH O a bond Q3a OH3842 N O Q1k′ a bond Me a bond NH O a bond Q3d OH 3843 N O Q1k′ a bondMe a bond NH O a bond Q3e OH 3844 N O Q1k′ a bond Me a bond NH O a bondQ3f OH 3845 N O Q1k′ a bond Me a bond NH O NH Q3a OH 3846 N O Q1k′ abond Me a bond NH O NH Q3d OH 3847 N O Q1k′ a bond Me a bond NH O NH Q3eOH 3848 N O Q1k′ a bond Me a bond NH O NH Q3f OH 3849 N O Q1k′ a bond Mea bond NH S a bond Q3a OH 3850 N O Q1k′ a bond Me a bond NH S a bond Q3dOH 3851 N O Q1k′ a bond Me a bond NH S a bond Q3e OH 3852 N O Q1k′ abond Me a bond NH S a bond Q3f OH 3853 N O Q1k′ a bond Me a bond NH S NHQ3a OH 3854 N O Q1k′ a bond Me a bond NH S NH Q3d OH 3855 N O Q1k′ abond Me a bond NH S NH Q3e OH 3856 N O Q1k′ a bond Me a bond NH S NH Q3fOH 3857 N O Q1l′ a bond Me a bond NH O a bond Q3a OH 3858 N O Q1l′ abond Me a bond NH O a bond Q3d OH 3859 N O Q1l′ a bond Me a bond NH O abond Q3e OH 3860 N O Q1l′ a bond Me a bond NH O a bond Q3f OH 3861 N OQ1l′ a bond Me a bond NH O NH Q3a OH 3862 N O Q1l′ a bond Me a bond NH ONH Q3d OH 3863 N O Q1l′ a bond Me a bond NH O NH Q3e OH 3864 N O Q1l′ abond Me a bond NH O NH Q3f OH 3865 N O Q1l′ a bond Me a bond NH S a bondQ3a OH 3866 N O Q1l′ a bond Me a bond NH S a bond Q3d OH 3867 N O Q1l′ abond Me a bond NH S a bond Q3e OH 3868 N O Q1l′ a bond Me a bond NH S abond Q3f OH 3869 N O Q1l′ a bond Me a bond NH S NH Q3a OH 3870 N O Q1l′a bond Me a bond NH S NH Q3d OH 3871 N O Q1l′ a bond Me a bond NH S NHQ3e OH 3872 N O Q1l′ a bond Me a bond NH S NH Q3f OH 3873 N O Q1m′ abond Me a bond NH O a bond Q3a OH 3874 N O Q1m′ a bond Me a bond NH O abond Q3d OH 3875 N O Q1m′ a bond Me a bond NH O a bond Q3e OH 3876 N OQ1m′ a bond Me a bond NH O a bond Q3f OH 3877 N O Q1m′ a bond Me a bondNH O NH Q3a OH 3878 N O Q1m′ a bond Me a bond NH O NH Q3d OH 3879 N OQ1m′ a bond Me a bond NH O NH Q3e OH 3880 N O Q1m′ a bond Me a bond NH ONH Q3f OH 3881 N O Q1m′ a bond Me a bond NH S a bond Q3a OH 3882 N OQ1m′ a bond Me a bond NH S a bond Q3d OH 3883 N O Q1m′ a bond Me a bondNH S a bond Q3e OH 3884 N O Q1m′ a bond Me a bond NH S a bond Q3f OH3885 N O Q1m′ a bond Me a bond NH S NH Q3a OH 3886 N O Q1m′ a bond Me abond NH S NH Q3d OH 3887 N O Q1m′ a bond Me a bond NH S NH Q3e OH 3888 NO Q1m′ a bond Me a bond NH S NH Q3f OH 3889 N O Q1n′ a bond Me a bond NHO a bond Q3a OH 3890 N O Q1n′ a bond Me a bond NH O a bond Q3d OH 3891 NO Q1n′ a bond Me a bond NH O a bond Q3e OH 3892 N O Q1n′ a bond Me abond NH O a bond Q3f OH 3893 N O Q1n′ a bond Me a bond NH O NH Q3a OH3894 N O Q1n′ a bond Me a bond NH O NH Q3d OH 3895 N O Q1n′ a bond Me abond NH O NH Q3e OH 3896 N O Q1n′ a bond Me a bond NH O NH Q3f OH 3897 NO Q1n′ a bond Me a bond NH S a bond Q3a OH 3898 N O Q1n′ a bond Me abond NH S a bond Q3d OH 3899 N O Q1n′ a bond Me a bond NH S a bond Q3eOH 3900 N O Q1n′ a bond Me a bond NH S a bond Q3f OH 3901 N O Q1n′ abond Me a bond NH S NH Q3a OH 3902 N O Q1n′ a bond Me a bond NH S NH Q3dOH 3903 N O Q1n′ a bond Me a bond NH S NH Q3e OH 3904 N O Q1n′ a bond Mea bond NH S NH Q3f OH 3905 CH NMe Q1k′ a bond Me a bond NH O a bond Q3aOH 3906 CH NMe Q1k′ a bond Me a bond NH O a bond Q3d OH 3907 CH NMe Q1k′a bond Me a bond NH O a bond Q3e OH 3908 CH NMe Q1k′ a bond Me a bond NHO a bond Q3f OH 3909 CH NMe Q1k′ a bond Me a bond NH O NH Q3a OH 3910 CHNMe Q1k′ a bond Me a bond NH O NH Q3d OH 3911 CH NMe Q1k′ a bond Me abond NH O NH Q3e OH 3912 CH NMe Q1k′ a bond Me a bond NH O NH Q3f OH3913 CH NMe Q1k′ a bond Me a bond NH S a bond Q3a OH 3914 CH NMe Q1k′ abond Me a bond NH S a bond Q3d OH 3915 CH NMe Q1k′ a bond Me a bond NH Sa bond Q3e OH 3916 CH NMe Q1k′ a bond Me a bond NH S a bond Q3f OH 3917CH NMe Q1k′ a bond Me a bond NH S NH Q3a OH 3918 CH NMe Q1k′ a bond Me abond NH S NH Q3d OH 3919 CH NMe Q1k′ a bond Me a bond NH S NH Q3e OH3920 CH NMe Q1k′ a bond Me a bond NH S NH Q3f OH 3921 CH NMe Q1l′ a bondMe a bond NH O a bond Q3a OH 3922 CH NMe Q1l′ a bond Me a bond NH O abond Q3d OH 3923 CH NMe Q1l′ a bond Me a bond NH O a bond Q3e OH 3924 CHNMe Q1l′ a bond Me a bond NH O a bond Q3f OH 3925 CH NMe Q1l′ a bond Mea bond NH O NH Q3a OH 3926 CH NMe Q1l′ a bond Me a bond NH O NH Q3d OH3927 CH NMe Q1l′ a bond Me a bond NH O NH Q3e OH 3928 CH NMe Q1l′ a bondMe a bond NH O NH Q3f OH 3929 CH NMe Q1l′ a bond Me a bond NH S a bondQ3a OH 3930 CH NMe Q1l′ a bond Me a bond NH S a bond Q3d OH 3931 CH NMeQ1l′ a bond Me a bond NH S a bond Q3e OH 3932 CH NMe Q1l′ a bond Me abond NH S a bond Q3f OH 3933 CH NMe Q1l′ a bond Me a bond NH S NH Q3a OH3934 CH NMe Q1l′ a bond Me a bond NH S NH Q3d OH 3935 CH NMe Q1l′ a bondMe a bond NH S NH Q3e OH 3936 CH NMe Q1l′ a bond Me a bond NH S NH Q3fOH 3937 CH NMe Q1m′ a bond Me a bond NH O a bond Q3a OH 3938 CH NMe Q1m′a bond Me a bond NH O a bond Q3d OH 3939 CH NMe Q1m′ a bond Me a bond NHO a bond Q3e OH 3940 CH NMe Q1m′ a bond Me a bond NH O a bond Q3f OH3941 CH NMe Q1m′ a bond Me a bond NH O NH Q3a OH 3942 CH NMe Q1m′ a bondMe a bond NH O NH Q3d OH 3943 CH NMe Q1m′ a bond Me a bond NH O NH Q3eOH 3944 CH NMe Q1m′ a bond Me a bond NH O NH Q3f OH 3945 CH NMe Q1m′ abond Me a bond NH S a bond Q3a OH 3946 CH NMe Q1m′ a bond Me a bond NH Sa bond Q3d OH 3947 CH NMe Q1m′ a bond Me a bond NH S a bond Q3e OH 3948CH NMe Q1m′ a bond Me a bond NH S a bond Q3f OH 3949 CH NMe Q1m′ a bondMe a bond NH S NH Q3a OH 3950 CH NMe Q1m′ a bond Me a bond NH S NH Q3dOH 3951 CH NMe Q1m′ a bond Me a bond NH S NH Q3e OH 3952 CH NMe Q1m′ abond Me a bond NH S NH Q3f OH 3953 CH NMe Q1n′ a bond Me a bond NH O abond Q3a OH 3954 CH NMe Q1n′ a bond Me a bond NH O a bond Q3d OH 3955 CHNMe Q1n′ a bond Me a bond NH O a bond Q3e OH 3956 CH NMe Q1n′ a bond Mea bond NH O a bond Q3f OH 3957 CH NMe Q1n′ a bond Me a bond NH O NH Q3aOH 3958 CH NMe Q1n′ a bond Me a bond NH O NH Q3d OH 3959 CH NMe Q1n′ abond Me a bond NH O NH Q3e OH 3960 CH NMe Q1n′ a bond Me a bond NH O NHQ3f OH 3961 CH NMe Q1n′ a bond Me a bond NH S a bond Q3a OH 3962 CH NMeQ1n′ a bond Me a bond NH S a bond Q3d OH 3963 CH NMe Q1n′ a bond Me abond NH S a bond Q3e OH 3964 CH NMe Q1n′ a bond Me a bond NH S a bondQ3f OH 3965 CH NMe Q1n′ a bond Me a bond NH S NH Q3a OH 3966 CH NMe Q1n′a bond Me a bond NH S NH Q3d OH 3967 CH NMe Q1n′ a bond Me a bond NH SNH Q3e OH 3968 CH NMe Q1n′ a bond Me a bond NH S NH Q3f OH 3969 CH NEtQ1k′ a bond Me a bond NH O a bond Q3a OH 3970 CH NEt Q1k′ a bond Me abond NH O a bond Q3d OH 3971 CH NEt Q1k′ a bond Me a bond NH O a bondQ3e OH 3972 CH NEt Q1k′ a bond Me a bond NH O a bond Q3f OH 3973 CH NEtQ1k′ a bond Me a bond NH O NH Q3a OH 3974 CH NEt Q1k′ a bond Me a bondNH O NH Q3d OH 3975 CH NEt Q1k′ a bond Me a bond NH O NH Q3e OH 3976 CHNEt Q1k′ a bond Me a bond NH O NH Q3f OH 3977 CH NEt Q1k′ a bond Me abond NH S a bond Q3a OH 3978 CH NEt Q1k′ a bond Me a bond NH S a bondQ3d OH 3979 CH NEt Q1k′ a bond Me a bond NH S a bond Q3e OH 3980 CH NEtQ1k′ a bond Me a bond NH S a bond Q3f OH 3981 CH NEt Q1k′ a bond Me abond NH S NH Q3a OH 3982 CH NEt Q1k′ a bond Me a bond NH S NH Q3d OH3983 CH NEt Q1k′ a bond Me a bond NH S NH Q3e OH 3984 CH NEt Q1k′ a bondMe a bond NH S NH Q3f OH 3985 CH NEt Q1l′ a bond Me a bond NH O a bondQ3a OH 3986 CH NEt Q1l′ a bond Me a bond NH O a bond Q3d OH 3987 CH NEtQ1l′ a bond Me a bond NH O a bond Q3e OH 3988 CH NEt Q1l′ a bond Me abond NH O a bond Q3f OH 3989 CH NEt Q1l′ a bond Me a bond NH O NH Q3a OH3990 CH NEt Q1l′ a bond Me a bond NH O NH Q3d OH 3991 CH NEt Q1l′ a bondMe a bond NH O NH Q3e OH 3992 CH NEt Q1l′ a bond Me a bond NH O NH Q3fOH 3993 CH NEt Q1l′ a bond Me a bond NH S a bond Q3a OH 3994 CH NEt Q1l′a bond Me a bond NH S a bond Q3d OH 3995 CH NEt Q1l′ a bond Me a bond NHS a bond Q3e OH 3996 CH NEt Q1l′ a bond Me a bond NH S a bond Q3f OH3997 CH NEt Q1l′ a bond Me a bond NH S NH Q3a OH 3998 CH NEt Q1l′ a bondMe a bond NH S NH Q3d OH 3999 CH NEt Q1l′ a bond Me a bond NH S NH Q3eOH 4000 CH NEt Q1l′ a bond Me a bond NH S NH Q3f OH 4001 CH NEt Q1m′ abond Me a bond NH O a bond Q3a OH 4002 CH NEt Q1m′ a bond Me a bond NH Oa bond Q3d OH 4003 CH NEt Q1m′ a bond Me a bond NH O a bond Q3e OH 4004CH NEt Q1m′ a bond Me a bond NH O a bond Q3f OH 4005 CH NEt Q1m′ a bondMe a bond NH O NH Q3a OH 4006 CH NEt Q1m′ a bond Me a bond NH O NH Q3dOH 4007 CH NEt Q1m′ a bond Me a bond NH O NH Q3e OH 4008 CH NEt Q1m′ abond Me a bond NH O NH Q3f OH 4009 CH NEt Q1m′ a bond Me a bond NH S abond Q3a OH 4010 CH NEt Q1m′ a bond Me a bond NH S a bond Q3d OH 4011 CHNEt Q1m′ a bond Me a bond NH S a bond Q3e OH 4012 CH NEt Q1m′ a bond Mea bond NH S a bond Q3f OH 4013 CH NEt Q1m′ a bond Me a bond NH S NH Q3aOH 4014 CH NEt Q1m′ a bond Me a bond NH S NH Q3d OH 4015 CH NEt Q1m′ abond Me a bond NH S NH Q3e OH 4016 CH NEt Q1m′ a bond Me a bond NH S NHQ3f OH 4017 CH NEt Q1n′ a bond Me a bond NH O a bond Q3a OH 4018 CH NEtQ1n′ a bond Me a bond NH O a bond Q3d OH 4019 CH NEt Q1n′ a bond Me abond NH O a bond Q3e OH 4020 CH NEt Q1n′ a bond Me a bond NH O a bondQ3f OH 4021 CH NEt Q1n′ a bond Me a bond NH O NH Q3a OH 4022 CH NEt Q1n′a bond Me a bond NH O NH Q3d OH 4023 CH NEt Q1n′ a bond Me a bond NH ONH Q3e OH 4024 CH NEt Q1n′ a bond Me a bond NH O NH Q3f OH 4025 CH NEtQ1n′ a bond Me a bond NH S a bond Q3a OH 4026 CH NEt Q1n′ a bond Me abond NH S a bond Q3d OH 4027 CH NEt Q1n′ a bond Me a bond NH S a bondQ3e OH 4028 CH NEt Q1n′ a bond Me a bond NH S a bond Q3f OH 4029 CH NEtQ1n′ a bond Me a bond NH S NH Q3a OH 4030 CH NEt Q1n′ a bond Me a bondNH S NH Q3d OH 4031 CH NEt Q1n′ a bond Me a bond NH S NH Q3e OH 4032 CHNEt Q1n′ a bond Me a bond NH S NH Q3f OH 4033 CH S Q1k′ a bond Me a bondNH O a bond Q3a OH 4034 CH S Q1k′ a bond Me a bond NH O a bond Q3d OH4035 CH S Q1k′ a bond Me a bond NH O a bond Q3e OH 4036 CH S Q1k′ a bondMe a bond NH O a bond Q3f OH 4037 CH S Q1k′ a bond Me a bond NH O NH Q3aOH 4038 CH S Q1k′ a bond Me a bond NH O NH Q3d OH 4039 CH S Q1k′ a bondMe a bond NH O NH Q3e OH 4040 CH S Q1k′ a bond Me a bond NH O NH Q3f OH4041 CH S Q1k′ a bond Me a bond NH S a bond Q3a OH 4042 CH S Q1k′ a bondMe a bond NH S a bond Q3d OH 4043 CH S Q1k′ a bond Me a bond NH S a bondQ3e OH 4044 CH S Q1k′ a bond Me a bond NH S a bond Q3f OH 4045 CH S Q1k′a bond Me a bond NH S NH Q3a OH 4046 CH S Q1k′ a bond Me a bond NH S NHQ3d OH 4047 CH S Q1k′ a bond Me a bond NH S NH Q3e OH 4048 CH S Q1k′ abond Me a bond NH S NH Q3f OH 4049 CH S Q1l′ a bond Me a bond NH O abond Q3a OH 4050 CH S Q1l′ a bond Me a bond NH O a bond Q3d OH 4051 CH SQ1l′ a bond Me a bond NH O a bond Q3e OH 4052 CH S Q1l′ a bond Me a bondNH O a bond Q3f OH 4053 CH S Q1l′ a bond Me a bond NH O NH Q3a OH 4054CH S Q1l′ a bond Me a bond NH O NH Q3d OH 4055 CH S Q1l′ a bond Me abond NH O NH Q3e OH 4056 CH S Q1l′ a bond Me a bond NH O NH Q3f OH 4057CH S Q1l′ a bond Me a bond NH S a bond Q3a OH 4058 CH S Q1l′ a bond Me abond NH S a bond Q3d OH 4059 CH S Q1l′ a bond Me a bond NH S a bond Q3eOH 4060 CH S Q1l′ a bond Me a bond NH S a bond Q3f OH 4061 CH S Q1l′ abond Me a bond NH S NH Q3a OH 4062 CH S Q1l′ a bond Me a bond NH S NHQ3d OH 4063 CH S Q1l′ a bond Me a bond NH S NH Q3e OH 4064 CH S Q1l′ abond Me a bond NH S NH Q3f OH 4065 CH S Q1m′ a bond Me a bond NH O abond Q3a OH 4066 CH S Q1m′ a bond Me a bond NH O a bond Q3d OH 4067 CH SQ1m′ a bond Me a bond NH O a bond Q3e OH 4068 CH S Q1m′ a bond Me a bondNH O a bond Q3f OH 4069 CH S Q1m′ a bond Me a bond NH O NH Q3a OH 4070CH S Q1m′ a bond Me a bond NH O NH Q3d OH 4071 CH S Q1m′ a bond Me abond NH O NH Q3e OH 4072 CH S Q1m′ a bond Me a bond NH O NH Q3f OH 4073CH S Q1m′ a bond Me a bond NH S a bond Q3a OH 4074 CH S Q1m′ a bond Me abond NH S a bond Q3d OH 4075 CH S Q1m′ a bond Me a bond NH S a bond Q3eOH 4076 CH S Q1m′ a bond Me a bond NH S a bond Q3f OH 4077 CH S Q1m′ abond Me a bond NH S NH Q3a OH 4078 CH S Q1m′ a bond Me a bond NH S NHQ3d OH 4079 CH S Q1m′ a bond Me a bond NH S NH Q3e OH 4080 CH S Q1m′ abond Me a bond NH S NH Q3f OH 4081 CH S Q1n′ a bond Me a bond NH O abond Q3a OH 4082 CH S Q1n′ a bond Me a bond NH O a bond Q3d OH 4083 CH SQ1n′ a bond Me a bond NH O a bond Q3e OH 4084 CH S Q1n′ a bond Me a bondNH O a bond Q3f OH 4085 CH S Q1n′ a bond Me a bond NH O NH Q3a OH 4086CH S Q1n′ a bond Me a bond NH O NH Q3d OH 4087 CH S Q1n′ a bond Me abond NH O NH Q3e OH 4088 CH S Q1n′ a bond Me a bond NH O NH Q3f OH 4089CH S Q1n′ a bond Me a bond NH S a bond Q3a OH 4090 CH S Q1n′ a bond Me abond NH S a bond Q3d OH 4091 CH S Q1n′ a bond Me a bond NH S a bond Q3eOH 4092 CH S Q1n′ a bond Me a bond NH S a bond Q3f OH 4093 CH S Q1n′ abond Me a bond NH S NH Q3a OH 4094 CH S Q1n′ a bond Me a bond NH S NHQ3d OH 4095 CH S Q1n′ a bond Me a bond NH S NH Q3e OH 4096 CH S Q1n′ abond Me a bond NH S NH Q3f OH 4097 CH O Q1k′ a bond Me a bond NH O abond Q3a OH 4098 CH O Q1k′ a bond Me a bond NH O a bond Q3d OH 4099 CH OQ1k′ a bond Me a bond NH O a bond Q3e OH 4100 CH O Q1k′ a bond Me a bondNH O a bond Q3f OH 4101 CH O Q1k′ a bond Me a bond NH O NH Q3a OH 4102CH O Q1k′ a bond Me a bond NH O NH Q3d OH 4103 CH O Q1k′ a bond Me abond NH O NH Q3e OH 4104 CH O Q1k′ a bond Me a bond NH O NH Q3f OH 4105CH O Q1k′ a bond Me a bond NH S a bond Q3a OH 4106 CH O Q1k′ a bond Me abond NH S a bond Q3d OH 4107 CH O Q1k′ a bond Me a bond NH S a bond Q3eOH 4108 CH O Q1k′ a bond Me a bond NH S a bond Q3f OH 4109 CH O Q1k′ abond Me a bond NH S NH Q3a OH 4110 CH O Q1k′ a bond Me a bond NH S NHQ3d OH 4111 CH O Q1k′ a bond Me a bond NH S NH Q3e OH 4112 CH O Q1k′ abond Me a bond NH S NH Q3f OH 4113 CH O Q1l′ a bond Me a bond NH O abond Q3a OH 4114 CH O Q1l′ a bond Me a bond NH O a bond Q3d OH 4115 CH OQ1l′ a bond Me a bond NH O a bond Q3e OH 4116 CH O Q1l′ a bond Me a bondNH O a bond Q3f OH 4117 CH O Q1l′ a bond Me a bond NH O NH Q3a OH 4118CH O Q1l′ a bond Me a bond NH O NH Q3d OH 4119 CH O Q1l′ a bond Me abond NH O NH Q3e OH 4120 CH O Q1l′ a bond Me a bond NH O NH Q3f OH 4121CH O Q1l′ a bond Me a bond NH S a bond Q3a OH 4122 CH O Q1l′ a bond Me abond NH S a bond Q3d OH 4123 CH O Q1l′ a bond Me a bond NH S a bond Q3eOH 4124 CH O Q1l′ a bond Me a bond NH S a bond Q3f OH 4125 CH O Q1l′ abond Me a bond NH S NH Q3a OH 4126 CH O Q1l′ a bond Me a bond NH S NHQ3d OH 4127 CH O Q1l′ a bond Me a bond NH S NH Q3e OH 4128 CH O Q1l′ abond Me a bond NH S NH Q3f OH 4129 CH O Q1m′ a bond Me a bond NH O abond Q3a OH 4130 CH O Q1m′ a bond Me a bond NH O a bond Q3d OH 4131 CH OQ1m′ a bond Me a bond NH O a bond Q3e OH 4132 CH O Q1m′ a bond Me a bondNH O a bond Q3f OH 4133 CH O Q1m′ a bond Me a bond NH O NH Q3a OH 4134CH O Q1m′ a bond Me a bond NH O NH Q3d OH 4135 CH O Q1m′ a bond Me abond NH O NH Q3e OH 4136 CH O Q1m′ a bond Me a bond NH O NH Q3f OH 4137CH O Q1m′ a bond Me a bond NH S a bond Q3a OH 4138 CH O Q1m′ a bond Me abond NH S a bond Q3d OH 4139 CH O Q1m′ a bond Me a bond NH S a bond Q3eOH 4140 CH O Q1m′ a bond Me a bond NH S a bond Q3f OH 4141 CH O Q1m′ abond Me a bond NH S NH Q3a OH 4142 CH O Q1m′ a bond Me a bond NH S NHQ3d OH 4143 CH O Q1m′ a bond Me a bond NH S NH Q3e OH 4144 CH O Q1m′ abond Me a bond NH S NH Q3f OH 4145 CH O Q1n′ a bond Me a bond NH O abond Q3a OH 4146 CH O Q1n′ a bond Me a bond NH O a bond Q3d OH 4147 CH OQ1n′ a bond Me a bond NH O a bond Q3e OH 4148 CH O Q1n′ a bond Me a bondNH O a bond Q3f OH 4149 CH O Q1n′ a bond Me a bond NH O NH Q3a OH 4150CH O Q1n′ a bond Me a bond NH O NH Q3d OH 4151 CH O Q1n′ a bond Me abond NH O NH Q3e OH 4152 CH O Q1n′ a bond Me a bond NH O NH Q3f OH 4153CH O Q1n′ a bond Me a bond NH S a bond Q3a OH 4154 CH O Q1n′ a bond Me abond NH S a bond Q3d OH 4155 CH O Q1n′ a bond Me a bond NH S a bond Q3eOH 4156 CH O Q1n′ a bond Me a bond NH S a bond Q3f OH 4157 CH O Q1n′ abond Me a bond NH S NH Q3a OH 4158 CH O Q1n′ a bond Me a bond NH S NHQ3d OH 4159 CH O Q1n′ a bond Me a bond NH S NH Q3e OH 4160 CH O Q1n′ abond Me a bond NH S NH Q3f OH 4161 CMe NMe Q1k′ a bond Me a bond NH O abond Q3a OH 4162 CMe NMe Q1k′ a bond Me a bond NH O a bond Q3d OH 4163CMe NMe Q1k′ a bond Me a bond NH O a bond Q3e OH 4164 CMe NMe Q1k′ abond Me a bond NH O a bond Q3f OH 4165 CMe NMe Q1k′ a bond Me a bond NHO NH Q3a OH 4166 CMe NMe Q1k′ a bond Me a bond NH O NH Q3d OH 4167 CMeNMe Q1k′ a bond Me a bond NH O NH Q3e OH 4168 CMe NMe Q1k′ a bond Me abond NH O NH Q3f OH 4169 CMe NMe Q1k′ a bond Me a bond NH S a bond Q3aOH 4170 CMe NMe Q1k′ a bond Me a bond NH S a bond Q3d OH 4171 CMe NMeQ1k′ a bond Me a bond NH S a bond Q3e OH 4172 CMe NMe Q1k′ a bond Me abond NH S a bond Q3f OH 4173 CMe NMe Q1k′ a bond Me a bond NH S NH Q3aOH 4174 CMe NMe Q1k′ a bond Me a bond NH S NH Q3d OH 4175 CMe NMe Q1k′ abond Me a bond NH S NH Q3e OH 4176 CMe NMe Q1k′ a bond Me a bond NH S NHQ3f OH 4177 CMe NMe Q1l′ a bond Me a bond NH O a bond Q3a OH 4178 CMeNMe Q1l′ a bond Me a bond NH O a bond Q3d OH 4179 CMe NMe Q1l′ a bond Mea bond NH O a bond Q3e OH 4180 CMe NMe Q1l′ a bond Me a bond NH O a bondQ3f OH 4181 CMe NMe Q1l′ a bond Me a bond NH O NH Q3a OH 4182 CMe NMeQ1l′ a bond Me a bond NH O NH Q3d OH 4183 CMe NMe Q1l′ a bond Me a bondNH O NH Q3e OH 4184 CMe NMe Q1l′ a bond Me a bond NH O NH Q3f OH 4185CMe NMe Q1l′ a bond Me a bond NH S a bond Q3a OH 4186 CMe NMe Q1l′ abond Me a bond NH S a bond Q3d OH 4187 CMe NMe Q1l′ a bond Me a bond NHS a bond Q3e OH 4188 CMe NMe Q1l′ a bond Me a bond NH S a bond Q3f OH4189 CMe NMe Q1l′ a bond Me a bond NH S NH Q3a OH 4190 CMe NMe Q1l′ abond Me a bond NH S NH Q3d OH 4191 CMe NMe Q1l′ a bond Me a bond NH S NHQ3e OH 4192 CMe NMe Q1l′ a bond Me a bond NH S NH Q3f OH 4193 CMe NMeQ1m′ a bond Me a bond NH O a bond Q3a OH 4194 CMe NMe Q1m′ a bond Me abond NH O a bond Q3d OH 4195 CMe NMe Q1m′ a bond Me a bond NH O a bondQ3e OH 4196 CMe NMe Q1m′ a bond Me a bond NH O a bond Q3f OH 4197 CMeNMe Q1m′ a bond Me a bond NH O NH Q3a OH 4198 CMe NMe Q1m′ a bond Me abond NH O NH Q3d OH 4199 CMe NMe Q1m′ a bond Me a bond NH O NH Q3e OH4200 CMe NMe Q1m′ a bond Me a bond NH O NH Q3f OH 4201 CMe NMe Q1m′ abond Me a bond NH S a bond Q3a OH 4202 CMe NMe Q1m′ a bond Me a bond NHS a bond Q3d OH 4203 CMe NMe Q1m′ a bond Me a bond NH S a bond Q3e OH4204 CMe NMe Q1m′ a bond Me a bond NH S a bond Q3f OH 4205 CMe NMe Q1m′a bond Me a bond NH S NH Q3a OH 4206 CMe NMe Q1m′ a bond Me a bond NH SNH Q3d OH 4207 CMe NMe Q1m′ a bond Me a bond NH S NH Q3e OH 4208 CMe NMeQ1m′ a bond Me a bond NH S NH Q3f OH 4209 CMe NMe Q1n′ a bond Me a bondNH O a bond Q3a OH 4210 CMe NMe Q1n′ a bond Me a bond NH O a bond Q3d OH4211 CMe NMe Q1n′ a bond Me a bond NH O a bond Q3e OH 4212 CMe NMe Q1n′a bond Me a bond NH O a bond Q3f OH 4213 CMe NMe Q1n′ a bond Me a bondNH O NH Q3a OH 4214 CMe NMe Q1n′ a bond Me a bond NH O NH Q3d OH 4215CMe NMe Q1n′ a bond Me a bond NH O NH Q3e OH 4216 CMe NMe Q1n′ a bond Mea bond NH O NH Q3f OH 4217 CMe NMe Q1n′ a bond Me a bond NH S a bond Q3aOH 4218 CMe NMe Q1n′ a bond Me a bond NH S a bond Q3d OH 4219 CMe NMeQ1n′ a bond Me a bond NH S a bond Q3e OH 4220 CMe NMe Q1n′ a bond Me abond NH S a bond Q3f OH 4221 CMe NMe Q1n′ a bond Me a bond NH S NH Q3aOH 4222 CMe NMe Q1n′ a bond Me a bond NH S NH Q3d OH 4223 CMe NMe Q1n′ abond Me a bond NH S NH Q3e OH 4224 CMe NMe Q1n′ a bond Me a bond NH S NHQ3f OH 4225 CMe NEt Q1k′ a bond Me a bond NH O a bond Q3a OH 4226 CMeNEt Q1k′ a bond Me a bond NH O a bond Q3d OH 4227 CMe NEt Q1k′ a bond Mea bond NH O a bond Q3e OH 4228 CMe NEt Q1k′ a bond Me a bond NH O a bondQ3f OH 4229 CMe NEt Q1k′ a bond Me a bond NH O NH Q3a OH 4230 CMe NEtQ1k′ a bond Me a bond NH O NH Q3d OH 4231 CMe NEt Q1k′ a bond Me a bondNH O NH Q3e OH 4232 CMe NEt Q1k′ a bond Me a bond NH O NH Q3f OH 4233CMe NEt Q1k′ a bond Me a bond NH S a bond Q3a OH 4234 CMe NEt Q1k′ abond Me a bond NH S a bond Q3d OH 4235 CMe NEt Q1k′ a bond Me a bond NHS a bond Q3e OH 4236 CMe NEt Q1k′ a bond Me a bond NH S a bond Q3f OH4237 CMe NEt Q1k′ a bond Me a bond NH S NH Q3a OH 4238 CMe NEt Q1k′ abond Me a bond NH S NH Q3d OH 4239 CMe NEt Q1k′ a bond Me a bond NH S NHQ3e OH 4240 CMe NEt Q1k′ a bond Me a bond NH S NH Q3f OH 4241 CMe NEtQ1l′ a bond Me a bond NH O a bond Q3a OH 4242 CMe NEt Q1l′ a bond Me abond NH O a bond Q3d OH 4243 CMe NEt Q1l′ a bond Me a bond NH O a bondQ3e OH 4244 CMe NEt Q1l′ a bond Me a bond NH O a bond Q3f OH 4245 CMeNEt Q1l′ a bond Me a bond NH O NH Q3a OH 4246 CMe NEt Q1l′ a bond Me abond NH O NH Q3d OH 4247 CMe NEt Q1l′ a bond Me a bond NH O NH Q3e OH4248 CMe NEt Q1l′ a bond Me a bond NH O NH Q3f OH 4249 CMe NEt Q1l′ abond Me a bond NH S a bond Q3a OH 4250 CMe NEt Q1l′ a bond Me a bond NHS a bond Q3d OH 4251 CMe NEt Q1l′ a bond Me a bond NH S a bond Q3e OH4252 CMe NEt Q1l′ a bond Me a bond NH S a bond Q3f OH 4253 CMe NEt Q1l′a bond Me a bond NH S NH Q3a OH 4254 CMe NEt Q1l′ a bond Me a bond NH SNH Q3d OH 4255 CMe NEt Q1l′ a bond Me a bond NH S NH Q3e OH 4256 CMe NEtQ1l′ a bond Me a bond NH S NH Q3f OH 4257 CMe NEt Q1m′ a bond Me a bondNH O a bond Q3a OH 4258 CMe NEt Q1m′ a bond Me a bond NH O a bond Q3d OH4259 CMe NEt Q1m′ a bond Me a bond NH O a bond Q3e OH 4260 CMe NEt Q1m′a bond Me a bond NH O a bond Q3f OH 4261 CMe NEt Q1m′ a bond Me a bondNH O NH Q3a OH 4262 CMe NEt Q1m′ a bond Me a bond NH O NH Q3d OH 4263CMe NEt Q1m′ a bond Me a bond NH O NH Q3e OH 4264 CMe NEt Q1m′ a bond Mea bond NH O NH Q3f OH 4265 CMe NEt Q1m′ a bond Me a bond NH S a bond Q3aOH 4266 CMe NEt Q1m′ a bond Me a bond NH S a bond Q3d OH 4267 CMe NEtQ1m′ a bond Me a bond NH S a bond Q3e OH 4268 CMe NEt Q1m′ a bond Me abond NH S a bond Q3f OH 4269 CMe NEt Q1m′ a bond Me a bond NH S NH Q3aOH 4270 CMe NEt Q1m′ a bond Me a bond NH S NH Q3d OH 4271 CMe NEt Q1m′ abond Me a bond NH S NH Q3e OH 4272 CMe NEt Q1m′ a bond Me a bond NH S NHQ3f OH 4273 CMe NEt Q1n′ a bond Me a bond NH O a bond Q3a OH 4274 CMeNEt Q1n′ a bond Me a bond NH O a bond Q3d OH 4275 CMe NEt Q1n′ a bond Mea bond NH O a bond Q3e OH 4276 CMe Net Q1n′ a bond Me a bond NH O a bondQ3f OH 4277 CMe NEt Q1n′ a bond Me a bond NH O NH Q3a OH 4278 CMe NEtQ1n′ a bond Me a bond NH O NH Q3d OH 4279 CMe NEt Q1n′ a bond Me a bondNH O NH Q3e OH 4280 CMe NEt Q1n′ a bond Me a bond NH O NH Q3f OH 4281CMe NEt Q1n′ a bond Me a bond NH S a bond Q3a OH 4282 CMe NEt Q1n′ abond Me a bond NH S a bond Q3d OH 4283 CMe NEt Q1n′ a bond Me a bond NHS a bond Q3e OH 4284 CMe NEt Q1n′ a bond Me a bond NH S a bond Q3f OH4285 CMe NEt Q1n′ a bond Me a bond NH S NH Q3a OH 4286 CMe NEt Q1n′ abond Me a bond NH S NH Q3d OH 4287 CMe NEt Q1n′ a bond Me a bond NH S NHQ3e OH 4288 CMe NEt Q1n′ a bond Me a bond NH S NH Q3f OH 4289 CMe S Q1k′a bond Me a bond NH O a bond Q3a OH 4290 CMe S Q1k′ a bond Me a bond NHO a bond Q3d OH 4291 CMe S Q1k′ a bond Me a bond NH O a bond Q3e OH 4292CMe S Q1k′ a bond Me a bond NH O a bond Q3f OH 4293 CMe S Q1k′ a bond Mea bond NH O NH Q3a OH 4294 CMe S Q1k′ a bond Me a bond NH O NH Q3d OH4295 CMe S Q1k′ a bond Me a bond NH O NH Q3e OH 4296 CMe S Q1k′ a bondMe a bond NH O NH Q3f OH 4297 CMe S Q1k′ a bond Me a bond NH S a bondQ3a OH 4298 CMe S Q1k′ a bond Me a bond NH S a bond Q3d OH 4299 CMe SQ1k′ a bond Me a bond NH S a bond Q3e OH 4300 CMe S Q1k′ a bond Me abond NH S a bond Q3f OH 4301 CMe S Q1k′ a bond Me a bond NH S NH Q3a OH4302 CMe S Q1k′ a bond Me a bond NH S NH Q3d OH 4303 CMe S Q1k′ a bondMe a bond NH S NH Q3e OH 4304 CMe S Q1k′ a bond Me a bond NH S NH Q3f OH4305 CMe S Q1l′ a bond Me a bond NH O a bond Q3a OH 4306 CMe S Q1l′ abond Me a bond NH O a bond Q3d OH 4307 CMe S Q1l′ a bond Me a bond NH Oa bond Q3e OH 4308 CMe S Q1l′ a bond Me a bond NH O a bond Q3f OH 4309CMe S Q1l′ a bond Me a bond NH O NH Q3a OH 4310 CMe S Q1l′ a bond Me abond NH O NH Q3d OH 4311 CMe S Q1l′ a bond Me a bond NH O NH Q3e OH 4312CMe S Q1l′ a bond Me a bond NH O NH Q3f OH 4313 CMe S Q1l′ a bond Me abond NH S a bond Q3a OH 4314 CMe S Q1l′ a bond Me a bond NH S a bond Q3dOH 4315 CMe S Q1l′ a bond Me a bond NH S a bond Q3e OH 4316 CMe S Q1l′ abond Me a bond NH S a bond Q3f OH 4317 CMe S Q1l′ a bond Me a bond NH SNH Q3a OH 4318 CMe S Q1l′ a bond Me a bond NH S NH Q3d OH 4319 CMe SQ1l′ a bond Me a bond NH S NH Q3e OH 4320 CMe S Q1l′ a bond Me a bond NHS NH Q3f OH 4321 CMe S Q1m′ a bond Me a bond NH O a bond Q3a OH 4322 CMeS Q1m′ a bond Me a bond NH O a bond Q3d OH 4323 CMe S Q1m′ a bond Me abond NH O a bond Q3e OH 4324 CMe S Q1m′ a bond Me a bond NH O a bond Q3fOH 4325 CMe S Q1m′ a bond Me a bond NH O NH Q3a OH 4326 CMe S Q1m′ abond Me a bond NH O NH Q3d OH 4327 CMe S Q1m′ a bond Me a bond NH O NHQ3e OH 4328 CMe S Q1m′ a bond Me a bond NH O NH Q3f OH 4329 CMe S Q1m′ abond Me a bond NH S a bond Q3a OH 4330 CMe S Q1m′ a bond Me a bond NH Sa bond Q3d OH 4331 CMe S Q1m′ a bond Me a bond NH S a bond Q3e OH 4332CMe S Q1m′ a bond Me a bond NH S a bond Q3f OH 4333 CMe S Q1m′ a bond Mea bond NH S NH Q3a OH 4334 CMe S Q1m′ a bond Me a bond NH S NH Q3d OH4335 CMe S Q1m′ a bond Me a bond NH S NH Q3e OH 4336 CMe S Q1m′ a bondMe a bond NH S NH Q3f OH 4337 CMe S Q1n′ a bond Me a bond NH O a bondQ3a OH 4338 CMe S Q1n′ a bond Me a bond NH O a bond Q3d OH 4339 CMe SQ1n′ a bond Me a bond NH O a bond Q3e OH 4340 CMe S Q1n′ a bond Me abond NH O a bond Q3f OH 4341 CMe S Q1n′ a bond Me a bond NH O NH Q3a OH4342 CMe S Q1n′ a bond Me a bond NH O NH Q3d OH 4343 CMe S Q1n′ a bondMe a bond NH O NH Q3e OH 4344 CMe S Q1n′ a bond Me a bond NH O NH Q3f OH4345 CMe S Q1n′ a bond Me a bond NH S a bond Q3a OH 4346 CMe S Q1n′ abond Me a bond NH S a bond Q3d OH 4347 CMe S Q1n′ a bond Me a bond NH Sa bond Q3e OH 4348 CMe S Q1n′ a bond Me a bond NH S a bond Q3f OH 4349CMe S Q1n′ a bond Me a bond NH S NH Q3a OH 4350 CMe S Q1n′ a bond Me abond NH S NH Q3d OH 4351 CMe S Q1n′ a bond Me a bond NH S NH Q3e OH 4352CMe S Q1n′ a bond Me a bond NH S NH Q3f OH 4353 CMe O Q1k′ a bond Me abond NH O a bond Q3a OH 4354 CMe O Q1k′ a bond Me a bond NH O a bond Q3dOH 4355 CMe O Q1k′ a bond Me a bond NH O a bond Q3e OH 4356 CMe O Q1k′ abond Me a bond NH O a bond Q3f OH 4357 CMe O Q1k′ a bond Me a bond NH ONH Q3a OH 4358 CMe O Q1k′ a bond Me a bond NH O NH Q3d OH 4359 CMe OQ1k′ a bond Me a bond NH O NH Q3e OH 4360 CMe O Q1k′ a bond Me a bond NHO NH Q3f OH 4361 CMe O Q1k′ a bond Me a bond NH S a bond Q3a OH 4362 CMeO Q1k′ a bond Me a bond NH S a bond Q3d OH 4363 CMe O Q1k′ a bond Me abond NH S a bond Q3e OH 4364 CMe O Q1k′ a bond Me a bond NH S a bond Q3fOH 4365 CMe O Q1k′ a bond Me a bond NH S NH Q3a OH 4366 CMe O Q1k′ abond Me a bond NH S NH Q3d OH 4367 CMe O Q1k′ a bond Me a bond NH S NHQ3e OH 4368 CMe O Q1k′ a bond Me a bond NH S NH Q3f OH 4369 CMe O Q1l′ abond Me a bond NH O a bond Q3a OH 4370 CMe O Q1l′ a bond Me a bond NH Oa bond Q3d OH 4371 CMe O Q1l′ a bond Me a bond NH O a bond Q3e OH 4372CMe O Q1l′ a bond Me a bond NH O a bond Q3f OH 4373 CMe O Q1l′ a bond Mea bond NH O NH Q3a OH 4374 CMe O Q1l′ a bond Me a bond NH O NH Q3d OH4375 CMe O Q1l′ a bond Me a bond NH O NH Q3e OH 4376 CMe O Q1l′ a bondMe a bond NH O NH Q3f OH 4377 CMe O Q1l′ a bond Me a bond NH S a bondQ3a OH 4378 CMe O Q1l′ a bond Me a bond NH S a bond Q3d OH 4379 CMe OQ1l′ a bond Me a bond NH S a bond Q3e OH 4380 CMe O Q1l′ a bond Me abond NH S a bond Q3f OH 4381 CMe O Q1l′ a bond Me a bond NH S NH Q3a OH4382 CMe O Q1l′ a bond Me a bond NH S NH Q3d OH 4383 CMe O Q1l′ a bondMe a bond NH S NH Q3e OH 4384 CMe O Q1l′ a bond Me a bond NH S NH Q3f OH4385 CMe O Q1m′ a bond Me a bond NH O a bond Q3a OH 4386 CMe O Q1m′ abond Me a bond NH O a bond Q3d OH 4387 CMe O Q1m′ a bond Me a bond NH Oa bond Q3e OH 4388 CMe O Q1m′ a bond Me a bond NH O a bond Q3f OH 4389CMe O Q1m′ a bond Me a bond NH O NH Q3a OH 4390 CMe O Q1m′ a bond Me abond NH O NH Q3d OH 4391 CMe O Q1m′ a bond Me a bond NH O NH Q3e OH 4392CMe O Q1m′ a bond Me a bond NH O NH Q3f OH 4393 CMe O Q1m′ a bond Me abond NH S a bond Q3a OH 4394 CMe O Q1m′ a bond Me a bond NH S a bond Q3dOH 4395 CMe O Q1m′ a bond Me a bond NH S a bond Q3e OH 4396 CMe O Q1m′ abond Me a bond NH S a bond Q3f OH 4397 CMe O Q1m′ a bond Me a bond NH SNH Q3a OH 4398 CMe O Q1m′ a bond Me a bond NH S NH Q3d OH 4399 CMe OQ1m′ a bond Me a bond NH S NH Q3e OH 4400 CMe O Q1m′ a bond Me a bond NHS NH Q3f OH 4401 CMe O Q1n′ a bond Me a bond NH O a bond Q3a OH 4402 CMeO Q1n′ a bond Me a bond NH O a bond Q3d OH 4403 CMe O Q1n′ a bond Me abond NH O a bond Q3e OH 4404 CMe O Q1n′ a bond Me a bond NH O a bond Q3fOH 4405 CMe O Q1n′ a bond Me a bond NH O NH Q3a OH 4406 CMe O Q1n′ abond Me a bond NH O NH Q3d OH 4407 CMe O Q1n′ a bond Me a bond NH O NHQ3e OH 4408 CMe O Q1n′ a bond Me a bond NH O NH Q3f OH 4409 CMe O Q1n′ abond Me a bond NH S a bond Q3a OH 4410 CMe O Q1n′ a bond Me a bond NH Sa bond Q3d OH 4411 CMe O Q1n′ a bond Me a bond NH S a bond Q3e OH 4412CMe O Q1n′ a bond Me a bond NH S a bond Q3f OH 4413 CMe O Q1n′ a bond Mea bond NH S NH Q3a OH 4414 CMe O Q1n′ a bond Me a bond NH S NH Q3d OH4415 CMe O Q1n′ a bond Me a bond NH S NH Q3e OH 4416 CMe O Q1n′ a bondMe a bond NH S NH Q3f OH 4417 N NMe Q1a a bond Me a bond NH O a bond Q3dOH 4418 N NMe Q1a a bond Me a bond NH O a bond Q3e OH 4419 N NMe Q1a abond Me a bond NH O a bond Q3f OH 4420 N NMe Q1a a bond Me a bond NH ONH Q3d OH 4421 N NMe Q1a a bond Me a bond NH O NH Q3e OH 4422 N NMe Q1aa bond Me a bond NH O NH Q3f OH 4423 N NMe Q1a a bond Me a bond NH S abond Q3d OH 4424 N NMe Q1a a bond Me a bond NH S a bond Q3e OH 4425 NNMe Q1a a bond Me a bond NH S a bond Q3f OH 4426 N NMe Q1a a bond Me abond NH S NH Q3d OH 4427 N NMe Q1a a bond Me a bond NH S NH Q3e OH 4428N NMe Q1a a bond Me a bond NH S NH Q3f OH 4429 N NMe Q1b a bond Me abond NH O a bond Q3d OH 4430 N NMe Q1b a bond Me a bond NH O a bond Q3eOH 4431 N NMe Q1b a bond Me a bond NH O a bond Q3f OH 4432 N NMe Q1b abond Me a bond NH O NH Q3d OH 4433 N NMe Q1b a bond Me a bond NH O NHQ3e OH 4434 N NMe Q1b a bond Me a bond NH O NH Q3f OH 4435 N NMe Q1b abond Me a bond NH S a bond Q3d OH 4436 N NMe Q1b a bond Me a bond NH S abond Q3e OH 4437 N NMe Q1b a bond Me a bond NH S a bond Q3f OH 4438 NNMe Q1b a bond Me a bond NH S NH Q3d OH 4439 N NMe Q1b a bond Me a bondNH S NH Q3e OH 4440 N NMe Q1b a bond Me a bond NH S NH Q3f OH 4441 N NMeQ1c a bond Me a bond NH O a bond Q3d OH 4442 N NMe Q1c a bond Me a bondNH O a bond Q3e OH 4443 N NMe Q1c a bond Me a bond NH O a bond Q3f OH4444 N NMe Q1c a bond Me a bond NH O NH Q3d OH 4445 N NMe Q1c a bond Mea bond NH O NH Q3e OH 4446 N NMe Q1c a bond Me a bond NH O NH Q3f OH4447 N NMe Q1c a bond Me a bond NH S a bond Q3d OH 4448 N NMe Q1c a bondMe a bond NH S a bond Q3e OH 4449 N NMe Q1c a bond Me a bond NH S a bondQ3f OH 4450 N NMe Q1c a bond Me a bond NH S NH Q3d OH 4451 N NMe Q1c abond Me a bond NH S NH Q3e OH 4452 N NMe Q1c a bond Me a bond NH S NHQ3f OH 4453 N NEt Q1a a bond Me a bond NH O a bond Q3d OH 4454 N NEt Q1aa bond Me a bond NH O a bond Q3e OH 4455 N NEt Q1a a bond Me a bond NH Oa bond Q3f OH 4456 N NEt Q1a a bond Me a bond NH O NH Q3d OH 4457 N NEtQ1a a bond Me a bond NH O NH Q3e OH 4458 N NEt Q1a a bond Me a bond NH ONH Q3f OH 4459 N NEt Q1a a bond Me a bond NH S a bond Q3d OH 4460 N NEtQ1a a bond Me a bond NH S a bond Q3e OH 4461 N NEt Q1a a bond Me a bondNH S a bond Q3f OH 4462 N NEt Q1a a bond Me a bond NH S NH Q3d OH 4463 NNEt Q1a a bond Me a bond NH S NH Q3e OH 4464 N NEt Q1a a bond Me a bondNH S NH Q3f OH 4465 N NEt Q1b a bond Me a bond NH O a bond Q3d OH 4466 NNEt Q1b a bond Me a bond NH O a bond Q3e OH 4467 N NEt Q1b a bond Me abond NH O a bond Q3f OH 4468 N NEt Q1b a bond Me a bond NH O NH Q3d OH4469 N NEt Q1b a bond Me a bond NH O NH Q3e OH 4470 N NEt Q1b a bond Mea bond NH O NH Q3f OH 4471 N NEt Q1b a bond Me a bond NH S a bond Q3d OH4472 N NEt Q1b a bond Me a bond NH S a bond Q3e OH 4473 N NEt Q1b a bondMe a bond NH S a bond Q3f OH 4474 N NEt Q1b a bond Me a bond NH S NH Q3dOH 4475 N NEt Q1b a bond Me a bond NH S NH Q3e OH 4476 N NEt Q1b a bondMe a bond NH S NH Q3f OH 4477 N NEt Q1c a bond Me a bond NH O a bond Q3dOH 4478 N NEt Q1c a bond Me a bond NH O a bond Q3e OH 4479 N NEt Q1c abond Me a bond NH O a bond Q3f OH 4480 N NEt Q1c a bond Me a bond NH ONH Q3d OH 4481 N NEt Q1c a bond Me a bond NH O NH Q3e OH 4482 N NEt Q1ca bond Me a bond NH O NH Q3f OH 4483 N NEt Q1c a bond Me a bond NH S abond Q3d OH 4484 N NEt Q1c a bond Me a bond NH S a bond Q3e OH 4485 NNEt Q1c a bond Me a bond NH S a bond Q3f OH 4486 N NEt Q1c a bond Me abond NH S NH Q3d OH 4487 N NEt Q1c a bond Me a bond NH S NH Q3e OH 4488N NEt Q1c a bond Me a bond NH S NH Q3f OH 4489 N S Q1a a bond Me a bondNH O a bond Q3d OH 4490 N S Q1a a bond Me a bond NH O a bond Q3e OH 4491N S Q1a a bond Me a bond NH O a bond Q3f OH 4492 N S Q1a a bond Me abond NH O NH Q3d OH 4493 N S Q1a a bond Me a bond NH O NH Q3e OH 4494 NS Q1a a bond Me a bond NH O NH Q3f OH 4495 N S Q1a a bond Me a bond NH Sa bond Q3d OH 4496 N S Q1a a bond Me a bond NH S a bond Q3e OH 4497 N SQ1a a bond Me a bond NH S a bond Q3f OH 4498 N S Q1a a bond Me a bond NHS NH Q3d OH 4499 N S Q1a a bond Me a bond NH S NH Q3e OH 4500 N S Q1a abond Me a bond NH S NH Q3f OH 4501 N S Q1b a bond Me a bond NH O a bondQ3d OH 4502 N S Q1b a bond Me a bond NH O a bond Q3e OH 4503 N S Q1b abond Me a bond NH O a bond Q3f OH 4504 N S Q1b a bond Me a bond NH O NHQ3d OH 4505 N S Q1b a bond Me a bond NH O NH Q3e OH 4506 N S Q1b a bondMe a bond NH O NH Q3f OH 4507 N S Q1b a bond Me a bond NH S a bond Q3dOH 4508 N S Q1b a bond Me a bond NH S a bond Q3e OH 4509 N S Q1b a bondMe a bond NH S a bond Q3f OH 4510 N S Q1b a bond Me a bond NH S NH Q3dOH 4511 N S Q1b a bond Me a bond NH S NH Q3e OH 4512 N S Q1b a bond Me abond NH S NH Q3f OH 4513 N S Q1c a bond Me a bond NH O a bond Q3d OH4514 N S Q1c a bond Me a bond NH O a bond Q3e OH 4515 N S Q1c a bond Mea bond NH O a bond Q3f OH 4516 N S Q1c a bond Me a bond NH O NH Q3d OH4517 N S Q1c a bond Me a bond NH O NH Q3e OH 4518 N S Q1c a bond Me abond NH O NH Q3f OH 4519 N S Q1c a bond Me a bond NH S a bond Q3d OH4520 N S Q1c a bond Me a bond NH S a bond Q3e OH 4521 N S Q1c a bond Mea bond NH S a bond Q3f OH 4522 N S Q1c a bond Me a bond NH S NH Q3d OH4523 N S Q1c a bond Me a bond NH S NH Q3e OH 4524 N S Q1c a bond Me abond NH S NH Q3f OH 4525 N O Q1a a bond Me a bond NH O a bond Q3d OH4526 N O Q1a a bond Me a bond NH O a bond Q3e OH 4527 N O Q1a a bond Mea bond NH O a bond Q3f OH 4528 N O Q1a a bond Me a bond NH O NH Q3d OH4529 N O Q1a a bond Me a bond NH O NH Q3e OH 4530 N O Q1a a bond Me abond NH O NH Q3f OH 4531 N O Q1a a bond Me a bond NH S a bond Q3d OH4532 N O Q1a a bond Me a bond NH S a bond Q3e OH 4533 N O Q1a a bond Mea bond NH S a bond Q3f OH 4534 N O Q1a a bond Me a bond NH S NH Q3d OH4535 N O Q1a a bond Me a bond NH S NH Q3e OH 4536 N O Q1a a bond Me abond NH S NH Q3f OH 4537 N O Q1b a bond Me a bond NH O a bond Q3d OH4538 N O Q1b a bond Me a bond NH O a bond Q3e OH 4539 N O Q1b a bond Mea bond NH O a bond Q3f OH 4540 N O Q1b a bond Me a bond NH O NH Q3d OH4541 N O Q1b a bond Me a bond NH O NH Q3e OH 4542 N O Q1b a bond Me abond NH O NH Q3f OH 4543 N O Q1b a bond Me a bond NH S a bond Q3d OH4544 N O Q1b a bond Me a bond NH S a bond Q3e OH 4545 N O Q1b a bond Mea bond NH S a bond Q3f OH 4546 N O Q1b a bond Me a bond NH S NH Q3d OH4547 N O Q1b a bond Me a bond NH S NH Q3e OH 4548 N O Q1b a bond Me abond NH S NH Q3f OH 4549 N O Q1c a bond Me a bond NH O a bond Q3d OH4550 N O Q1c a bond Me a bond NH O a bond Q3e OH 4551 N O Q1c a bond Mea bond NH O a bond Q3f OH 4552 N O Q1c a bond Me a bond NH O NH Q3d OH4553 N O Q1c a bond Me a bond NH O NH Q3e OH 4554 N O Q1c a bond Me abond NH O NH Q3f OH 4555 N O Q1c a bond Me a bond NH S a bond Q3d OH4556 N O Q1c a bond Me a bond NH S a bond Q3e OH 4557 N O Q1c a bond Mea bond NH S a bond Q3f OH 4558 N O Q1c a bond Me a bond NH S NH Q3d OH4559 N O Q1c a bond Me a bond NH S NH Q3e OH 4560 N O Q1c a bond Me abond NH S NH Q3f OH 4561 CH NMe Q1a a bond Me a bond NH O a bond Q3d OH4562 CH NMe Q1a a bond Me a bond NH O a bond Q3e OH 4563 CH NMe Q1a abond Me a bond NH O a bond Q3f OH 4564 CH NMe Q1a a bond Me a bond NH ONH Q3d OH 4565 CH NMe Q1a a bond Me a bond NH O NH Q3e OH 4566 CH NMeQ1a a bond Me a bond NH O NH Q3f OH 4567 CH NMe Q1a a bond Me a bond NHS a bond Q3d OH 4568 CH NMe Q1a a bond Me a bond NH S a bond Q3e OH 4569CH NMe Q1a a bond Me a bond NH S a bond Q3f OH 4570 CH NMe Q1a a bond Mea bond NH S NH Q3d OH 4571 CH NMe Q1a a bond Me a bond NH S NH Q3e OH4572 CH NMe Q1a a bond Me a bond NH S NH Q3f OH 4573 CH NMe Q1b a bondMe a bond NH O a bond Q3d OH 4574 CH NMe Q1b a bond Me a bond NH O abond Q3e OH 4575 CH NMe Q1b a bond Me a bond NH O a bond Q3f OH 4576 CHNMe Q1b a bond Me a bond NH O NH Q3d OH 4577 CH NMe Q1b a bond Me a bondNH O NH Q3e OH 4578 CH NMe Q1b a bond Me a bond NH O NH Q3f OH 4579 CHNMe Q1b a bond Me a bond NH S a bond Q3d OH 4580 CH NMe Q1b a bond Me abond NH S a bond Q3e OH 4581 CH NMe Q1b a bond Me a bond NH S a bond Q3fOH 4582 CH NMe Q1b a bond Me a bond NH S NH Q3d OH 4583 CH NMe Q1b abond Me a bond NH S NH Q3e OH 4584 CH NMe Q1b a bond Me a bond NH S NHQ3f OH 4585 CH NMe Q1c a bond Me a bond NH O a bond Q3d OH 4586 CH NMeQ1c a bond Me a bond NH O a bond Q3e OH 4587 CH NMe Q1c a bond Me a bondNH O a bond Q3f OH 4588 CH NMe Q1c a bond Me a bond NH O NH Q3d OH 4589CH NMe Q1c a bond Me a bond NH O NH Q3e OH 4590 CH NMe Q1c a bond Me abond NH O NH Q3f OH 4591 CH NMe Q1c a bond Me a bond NH S a bond Q3d OH4592 CH NMe Q1c a bond Me a bond NH S a bond Q3e OH 4593 CH NMe Q1c abond Me a bond NH S a bond Q3f OH 4594 CH NMe Q1c a bond Me a bond NH SNH Q3d OH 4595 CH NMe Q1c a bond Me a bond NH S NH Q3e OH 4596 CH NMeQ1c a bond Me a bond NH S NH Q3f OH 4597 CH NEt Q1a a bond Me a bond NHO a bond Q3d OH 4598 CH NEt Q1a a bond Me a bond NH O a bond Q3e OH 4599CH NEt Q1a a bond Me a bond NH O a bond Q3f OH 4600 CH NEt Q1a a bond Mea bond NH O NH Q3d OH 4601 CH NEt Q1a a bond Me a bond NH O NH Q3e OH4602 CH NEt Q1a a bond Me a bond NH O NH Q3f OH 4603 CH NEt Q1a a bondMe a bond NH S a bond Q3d OH 4604 CH NEt Q1a a bond Me a bond NH S abond Q3e OH 4605 CH NEt Q1a a bond Me a bond NH S a bond Q3f OH 4606 CHNEt Q1a a bond Me a bond NH S NH Q3d OH 4607 CH NEt Q1a a bond Me a bondNH S NH Q3e OH 4608 CH NEt Q1a a bond Me a bond NH S NH Q3f OH 4609 CHNEt Q1b a bond Me a bond NH O a bond Q3d OH 4610 CH NEt Q1b a bond Me abond NH O a bond Q3e OH 4611 CH NEt Q1b a bond Me a bond NH O a bond Q3fOH 4612 CH NEt Q1b a bond Me a bond NH O NH Q3d OH 4613 CH NEt Q1b abond Me a bond NH O NH Q3e OH 4614 CH NEt Q1b a bond Me a bond NH O NHQ3f OH 4615 CH NEt Q1b a bond Me a bond NH S a bond Q3d OH 4616 CH NEtQ1b a bond Me a bond NH S a bond Q3e OH 4617 CH NEt Q1b a bond Me a bondNH S a bond Q3f OH 4618 CH NEt Q1b a bond Me a bond NH S NH Q3d OH 4619CH NEt Q1b a bond Me a bond NH S NH Q3e OH 4620 CH NEt Q1b a bond Me abond NH S NH Q3f OH 4621 CH NEt Q1c a bond Me a bond NH O a bond Q3d OH4622 CH NEt Q1c a bond Me a bond NH O a bond Q3e OH 4623 CH NEt Q1c abond Me a bond NH O a bond Q3f OH 4624 CH NEt Q1c a bond Me a bond NH ONH Q3d OH 4625 CH NEt Q1c a bond Me a bond NH O NH Q3e OH 4626 CH NEtQ1c a bond Me a bond NH O NH Q3f OH 4627 CH NEt Q1c a bond Me a bond NHS a bond Q3d OH 4628 CH NEt Q1c a bond Me a bond NH S a bond Q3e OH 4629CH NEt Q1c a bond Me a bond NH S a bond Q3f OH 4630 CH NEt Q1c a bond Mea bond NH S NH Q3d OH 4631 CH NEt Q1c a bond Me a bond NH S NH Q3e OH4632 CH NEt Q1c a bond Me a bond NH S NH Q3f OH 4633 CH S Q1a a bond Mea bond NH O a bond Q3d OH 4634 CH S Q1a a bond Me a bond NH O a bond Q3eOH 4635 CH S Q1a a bond Me a bond NH O a bond Q3f OH 4636 CH S Q1a abond Me a bond NH O NH Q3d OH 4637 CH S Q1a a bond Me a bond NH O NH Q3eOH 4638 CH S Q1a a bond Me a bond NH O NH Q3f OH 4639 CH S Q1a a bond Mea bond NH S a bond Q3d OH 4640 CH S Q1a a bond Me a bond NH S a bond Q3eOH 4641 CH S Q1a a bond Me a bond NH S a bond Q3f OH 4642 CH S Q1a abond Me a bond NH S NH Q3d OH 4643 CH S Q1a a bond Me a bond NH S NH Q3eOH 4644 CH S Q1a a bond Me a bond NH S NH Q3f OH 4645 CH S Q1b a bond Mea bond NH O a bond Q3d OH 4646 CH S Q1b a bond Me a bond NH O a bond Q3eOH 4647 CH S Q1b a bond Me a bond NH O a bond Q3f OH 4648 CH S Q1b abond Me a bond NH O NH Q3d OH 4649 CH S Q1b a bond Me a bond NH O NH Q3eOH 4650 CH S Q1b a bond Me a bond NH O NH Q3f OH 4651 CH S Q1b a bond Mea bond NH S a bond Q3d OH 4652 CH S Q1b a bond Me a bond NH S a bond Q3eOH 4653 CH S Q1b a bond Me a bond NH S a bond Q3f OH 4654 CH S Q1b abond Me a bond NH S NH Q3d OH 4655 CH S Q1b a bond Me a bond NH S NH Q3eOH 4656 CH S Q1b a bond Me a bond NH S NH Q3f OH 4657 CH S Q1c a bond Mea bond NH O a bond Q3d OH 4658 CH S Q1c a bond Me a bond NH O a bond Q3eOH 4659 CH S Q1c a bond Me a bond NH O a bond Q3f OH 4660 CH S Q1c abond Me a bond NH O NH Q3d OH 4661 CH S Q1c a bond Me a bond NH O NH Q3eOH 4662 CH S Q1c a bond Me a bond NH O NH Q3f OH 4663 CH S Q1c a bond Mea bond NH S a bond Q3d OH 4664 CH S Q1c a bond Me a bond NH S a bond Q3eOH 4665 CH S Q1c a bond Me a bond NH S a bond Q3f OH 4666 CH S Q1c abond Me a bond NH S NH Q3d OH 4667 CH S Q1c a bond Me a bond NH S NH Q3eOH 4668 CH S Q1c a bond Me a bond NH S NH Q3f OH 4669 CH O Q1a a bond Mea bond NH O a bond Q3d OH 4670 CH O Q1a a bond Me a bond NH O a bond Q3eOH 4671 CH O Q1a a bond Me a bond NH O a bond Q3f OH 4672 CH O Q1a abond Me a bond NH O NH Q3d OH 4673 CH O Q1a a bond Me a bond NH O NH Q3eOH 4674 CH O Q1a a bond Me a bond NH O NH Q3f OH 4675 CH O Q1a a bond Mea bond NH S a bond Q3d OH 4676 CH O Q1a a bond Me a bond NH S a bond Q3eOH 4677 CH O Q1a a bond Me a bond NH S a bond Q3f OH 4678 CH O Q1a abond Me a bond NH S NH Q3d OH 4679 CH O Q1a a bond Me a bond NH S NH Q3eOH 4680 CH O Q1a a bond Me a bond NH S NH Q3f OH 4681 CH O Q1b a bond Mea bond NH O a bond Q3d OH 4682 CH O Q1b a bond Me a bond NH O a bond Q3eOH 4683 CH O Q1b a bond Me a bond NH O a bond Q3f OH 4684 CH O Q1b abond Me a bond NH O NH Q3d OH 4685 CH O Q1b a bond Me a bond NH O NH Q3eOH 4686 CH O Q1b a bond Me a bond NH O NH Q3f OH 4687 CH O Q1b a bond Mea bond NH S a bond Q3d OH 4688 CH O Q1b a bond Me a bond NH S a bond Q3eOH 4689 CH O Q1b a bond Me a bond NH S a bond Q3f OH 4690 CH O Q1b abond Me a bond NH S NH Q3d OH 4691 CH O Q1b a bond Me a bond NH S NH Q3eOH 4692 CH O Q1b a bond Me a bond NH S NH Q3f OH 4693 CH O Q1c a bond Mea bond NH O a bond Q3d OH 4694 CH O Q1c a bond Me a bond NH O a bond Q3eOH 4695 CH O Q1c a bond Me a bond NH O a bond Q3f OH 4696 CH O Q1c abond Me a bond NH O NH Q3d OH 4697 CH O Q1c a bond Me a bond NH O NH Q3eOH 4698 CH O Q1c a bond Me a bond NH O NH Q3f OH 4699 CH O Q1c a bond Mea bond NH S a bond Q3d OH 4700 CH O Q1c a bond Me a bond NH S a bond Q3eOH 4701 CH O Q1c a bond Me a bond NH S a bond Q3f OH 4702 CH O Q1c abond Me a bond NH S NH Q3d OH 4703 CH O Q1c a bond Me a bond NH S NH Q3eOH 4704 CH O Q1c a bond Me a bond NH S NH Q3f OH 4705 CMe NMe Q1a a bondMe a bond NH O a bond Q3d OH 4706 CMe NMe Q1a a bond Me a bond NH O abond Q3e OH 4707 CMe NMe Q1a a bond Me a bond NH O a bond Q3f OH 4708CMe NMe Q1a a bond Me a bond NH O NH Q3d OH 4709 CMe NMe Q1a a bond Me abond NH O NH Q3e OH 4710 CMe NMe Q1a a bond Me a bond NH O NH Q3f OH4711 CMe NMe Q1a a bond Me a bond NH S a bond Q3d OH 4712 CMe NMe Q1a abond Me a bond NH S a bond Q3e OH 4713 CMe NMe Q1a a bond Me a bond NH Sa bond Q3f OH 4714 CMe NMe Q1a a bond Me a bond NH S NH Q3d OH 4715 CMeNMe Q1a a bond Me a bond NH S NH Q3e OH 4716 CMe NMe Q1a a bond Me abond NH S NH Q3f OH 4717 CMe NMe Q1b a bond Me a bond NH O a bond Q3d OH4718 CMe NMe Q1b a bond Me a bond NH O a bond Q3e OH 4719 CMe NMe Q1b abond Me a bond NH O a bond Q3f OH 4720 CMe NMe Q1b a bond Me a bond NH ONH Q3d OH 4721 CMe NMe Q1b a bond Me a bond NH O NH Q3e OH 4722 CMe NMeQ1b a bond Me a bond NH O NH Q3f OH 4723 CMe NMe Q1b a bond Me a bond NHS a bond Q3d OH 4724 CMe NMe Q1b a bond Me a bond NH S a bond Q3e OH4725 CMe NMe Q1b a bond Me a bond NH S a bond Q3f OH 4726 CMe NMe Q1b abond Me a bond NH S NH Q3d OH 4727 CMe NMe Q1b a bond Me a bond NH S NHQ3e OH 4728 CMe NMe Q1b a bond Me a bond NH S NH Q3f OH 4729 CMe NMe Q1ca bond Me a bond NH O a bond Q3d OH 4730 CMe NMe Q1c a bond Me a bond NHO a bond Q3e OH 4731 CMe NMe Q1c a bond Me a bond NH O a bond Q3f OH4732 CMe NMe Q1c a bond Me a bond NH O NH Q3d OH 4733 CMe NMe Q1c a bondMe a bond NH O NH Q3e OH 4734 CMe NMe Q1c a bond Me a bond NH O NH Q3fOH 4735 CMe NMe Q1c a bond Me a bond NH S a bond Q3d OH 4736 CMe NMe Q1ca bond Me a bond NH S a bond Q3e OH 4737 CMe NMe Q1c a bond Me a bond NHS a bond Q3f OH 4738 CMe NMe Q1c a bond Me a bond NH S NH Q3d OH 4739CMe NMe Q1c a bond Me a bond NH S NH Q3e OH 4740 CMe NMe Q1c a bond Me abond NH S NH Q3f OH 4741 CMe NEt Q1a a bond Me a bond NH O a bond Q3d OH4742 CMe NEt Q1a a bond Me a bond NH O a bond Q3e OH 4743 CMe NEt Q1a abond Me a bond NH O a bond Q3f OH 4744 CMe NEt Q1a a bond Me a bond NH ONH Q3d OH 4745 CMe NEt Q1a a bond Me a bond NH O NH Q3e OH 4746 CMe NEtQ1a a bond Me a bond NH O NH Q3f OH 4747 CMe NEt Q1a a bond Me a bond NHS a bond Q3d OH 4748 CMe NEt Q1a a bond Me a bond NH S a bond Q3e OH4749 CMe NEt Q1a a bond Me a bond NH S a bond Q3f OH 4750 CMe NEt Q1a abond Me a bond NH S NH Q3d OH 4751 CMe NEt Q1a a bond Me a bond NH S NHQ3e OH 4752 CMe NEt Q1a a bond Me a bond NH S NH Q3f OH 4753 CMe NEt Q1ba bond Me a bond NH O a bond Q3d OH 4754 CMe NEt Q1b a bond Me a bond NHO a bond Q3e OH 4755 CMe NEt Q1b a bond Me a bond NH O a bond Q3f OH4756 CMe NEt Q1b a bond Me a bond NH O NH Q3d OH 4757 CMe NEt Q1b a bondMe a bond NH O NH Q3e OH 4758 CMe NEt Q1b a bond Me a bond NH O NH Q3fOH 4759 CMe NEt Q1b a bond Me a bond NH S a bond Q3d OH 4760 CMe NEt Q1ba bond Me a bond NH S a bond Q3e OH 4761 CMe NEt Q1b a bond Me a bond NHS a bond Q3f OH 4762 CMe NEt Q1b a bond Me a bond NH S NH Q3d OH 4763CMe NEt Q1b a bond Me a bond NH S NH Q3e OH 4764 CMe NEt Q1b a bond Me abond NH S NH Q3f OH 4765 CMe NEt Q1c a bond Me a bond NH O a bond Q3d OH4766 CMe NEt Q1c a bond Me a bond NH O a bond Q3e OH 4767 CMe NEt Q1c abond Me a bond NH O a bond Q3f OH 4768 CMe NEt Q1c a bond Me a bond NH ONH Q3d OH 4769 CMe NEt Q1c a bond Me a bond NH O NH Q3e OH 4770 CMe NEtQ1c a bond Me a bond NH O NH Q3f OH 4771 CMe NEt Q1c a bond Me a bond NHS a bond Q3d OH 4772 CMe NEt Q1c a bond Me a bond NH S a bond Q3e OH4773 CMe NEt Q1c a bond Me a bond NH S a bond Q3f OH 4774 CMe NEt Q1c abond Me a bond NH S NH Q3d OH 4775 CMe NEt Q1c a bond Me a bond NH S NHQ3e OH 4776 CMe NEt Q1c a bond Me a bond NH S NH Q3f OH 4777 CMe S Q1a abond Me a bond NH O a bond Q3d OH 4778 CMe S Q1a a bond Me a bond NH O abond Q3e OH 4779 CMe S Q1a a bond Me a bond NH O a bond Q3f OH 4780 CMeS Q1a a bond Me a bond NH O NH Q3d OH 4781 CMe S Q1a a bond Me a bond NHO NH Q3e OH 4782 CMe S Q1a a bond Me a bond NH O NH Q3f OH 4783 CMe SQ1a a bond Me a bond NH S a bond Q3d OH 4784 CMe S Q1a a bond Me a bondNH S a bond Q3e OH 4785 CMe S Q1a a bond Me a bond NH S a bond Q3f OH4786 CMe S Q1a a bond Me a bond NH S NH Q3d OH 4787 CMe S Q1a a bond Mea bond NH S NH Q3e OH 4788 CMe S Q1a a bond Me a bond NH S NH Q3f OH4789 CMe S Q1b a bond Me a bond NH O a bond Q3d OH 4790 CMe S Q1b a bondMe a bond NH O a bond Q3e OH 4791 CMe S Q1b a bond Me a bond NH O a bondQ3f OH 4792 CMe S Q1b a bond Me a bond NH O NH Q3d OH 4793 CMe S Q1b abond Me a bond NH O NH Q3e OH 4794 CMe S Q1b a bond Me a bond NH O NHQ3f OH 4795 CMe S Q1b a bond Me a bond NH S a bond Q3d OH 4796 CMe S Q1ba bond Me a bond NH S a bond Q3e OH 4797 CMe S Q1b a bond Me a bond NH Sa bond Q3f OH 4798 CMe S Q1b a bond Me a bond NH S NH Q3d OH 4799 CMe SQ1b a bond Me a bond NH S NH Q3e OH 4800 CMe S Q1b a bond Me a bond NH SNH Q3f OH 4801 CMe S Q1c a bond Me a bond NH O a bond Q3d OH 4802 CMe SQ1c a bond Me a bond NH O a bond Q3e OH 4803 CMe S Q1c a bond Me a bondNH O a bond Q3f OH 4804 CMe S Q1c a bond Me a bond NH O NH Q3d OH 4805CMe S Q1c a bond Me a bond NH O NH Q3e OH 4806 CMe S Q1c a bond Me abond NH O NH Q3f OH 4807 CMe S Q1c a bond Me a bond NH S a bond Q3d OH4808 CMe S Q1c a bond Me a bond NH S a bond Q3e OH 4809 CMe S Q1c a bondMe a bond NH S a bond Q3f OH 4810 CMe S Q1c a bond Me a bond NH S NH Q3dOH 4811 CMe S Q1c a bond Me a bond NH S NH Q3e OH 4812 CMe S Q1c a bondMe a bond NH S NH Q3f OH 4813 CMe O Q1a a bond Me a bond NH O a bond Q3dOH 4814 CMe O Q1a a bond Me a bond NH O a bond Q3e OH 4815 CMe O Q1a abond Me a bond NH O a bond Q3f OH 4816 CMe O Q1a a bond Me a bond NH ONH Q3d OH 4817 CMe O Q1a a bond Me a bond NH O NH Q3e OH 4818 CMe O Q1aa bond Me a bond NH O NH Q3f OH 4819 CMe O Q1a a bond Me a bond NH S abond Q3d OH 4820 CMe O Q1a a bond Me a bond NH S a bond Q3e OH 4821 CMeO Q1a a bond Me a bond NH S a bond Q3f OH 4822 CMe O Q1a a bond Me abond NH S NH Q3d OH 4823 CMe O Q1a a bond Me a bond NH S NH Q3e OH 4824CMe O Q1a a bond Me a bond NH S NH Q3f OH 4825 CMe O Q1b a bond Me abond NH O a bond Q3d OH 4826 CMe O Q1b a bond Me a bond NH O a bond Q3eOH 4827 CMe O Q1b a bond Me a bond NH O a bond Q3f OH 4828 CMe O Q1b abond Me a bond NH O NH Q3d OH 4829 CMe O Q1b a bond Me a bond NH O NHQ3e OH 4830 CMe O Q1b a bond Me a bond NH O NH Q3f OH 4831 CMe O Q1b abond Me a bond NH S a bond Q3d OH 4832 CMe O Q1b a bond Me a bond NH S abond Q3e OH 4833 CMe O Q1b a bond Me a bond NH S a bond Q3f OH 4834 CMeO Q1b a bond Me a bond NH S NH Q3d OH 4835 CMe O Q1b a bond Me a bond NHS NH Q3e OH 4836 CMe O Q1b a bond Me a bond NH S NH Q3f OH 4837 CMe OQ1c a bond Me a bond NH O a bond Q3d OH 4838 CMe O Q1c a bond Me a bondNH O a bond Q3e OH 4839 CMe O Q1c a bond Me a bond NH O a bond Q3f OH4840 CMe O Q1c a bond Me a bond NH O NH Q3d OH 4841 CMe O Q1c a bond Mea bond NH O NH Q3e OH 4842 CMe O Q1c a bond Me a bond NH O NH Q3f OH4843 CMe O Q1c a bond Me a bond NH S a bond Q3d OH 4844 CMe O Q1c a bondMe a bond NH S a bond Q3e OH 4845 CMe O Q1c a bond Me a bond NH S a bondQ3f OH 4846 CMe O Q1c a bond Me a bond NH S NH Q3d OH 4847 CMe O Q1c abond Me a bond NH S NH Q3e OH 4848 CMe O Q1c a bond Me a bond NH S NHQ3f OH 4849 N NMe Q1a a bond Me a bond NH S NH Q3g OH 4850 N NMe Q1a abond Me a bond NH S NH Q3h OH 4851 N NMe Q1b a bond Me a bond NH S NHQ3g OH 4852 N NMe Q1b a bond Me a bond NH S NH Q3h OH 4853 N NMe Q1c abond Me a bond NH S NH Q3g OH 4854 N NMe Q1c a bond Me a bond NH S NHQ3h OH 4855 N NEt Q1a a bond Me a bond NH S NH Q3g OH 4856 N NEt Q1a abond Me a bond NH S NH Q3h OH 4857 N NEt Q1b a bond Me a bond NH S NHQ3g OH 4858 N NEt Q1b a bond Me a bond NH S NH Q3h OH 4859 N NEt Q1c abond Me a bond NH S NH Q3g OH 4860 N NEt Q1c a bond Me a bond NH S NHQ3h OH 4861 N S Q1a a bond Me a bond NH S NH Q3g OH 4862 N S Q1a a bondMe a bond NH S NH Q3h OH 4863 N S Q1b a bond Me a bond NH S NH Q3g OH4864 N S Q1b a bond Me a bond NH S NH Q3h OH 4865 N S Q1c a bond Me abond NH S NH Q3g OH 4866 N S Q1c a bond Me a bond NH S NH Q3h OH 4867 NO Q1a a bond Me a bond NH S NH Q3g OH 4868 N O Q1a a bond Me a bond NH SNH Q3h OH 4869 N O Q1b a bond Me a bond NH S NH Q3g OH 4870 N O Q1b abond Me a bond NH S NH Q3h OH 4871 N O Q1c a bond Me a bond NH S NH Q3gOH 4872 N O Q1c a bond Me a bond NH S NH Q3h OH 4873 CH NMe Q1a a bondMe a bond NH S NH Q3g OH 4874 CH NMe Q1a a bond Me a bond NH S NH Q3h OH4875 CH NMe Q1b a bond Me a bond NH S NH Q3g OH 4876 CH NMe Q1b a bondMe a bond NH S NH Q3h OH 4877 CH NMe Q1c a bond Me a bond NH S NH Q3g OH4878 CH NMe Q1c a bond Me a bond NH S NH Q3h OH 4879 CH NEt Q1a a bondMe a bond NH S NH Q3g OH 4880 CH NEt Q1a a bond Me a bond NH S NH Q3h OH4881 CH NEt Q1b a bond Me a bond NH S NH Q3g OH 4882 CH NEt Q1b a bondMe a bond NH S NH Q3h OH 4883 CH NEt Q1c a bond Me a bond NH S NH Q3g OH4884 CH NEt Q1c a bond Me a bond NH S NH Q3h OH 4885 CH S Q1a a bond Mea bond NH S NH Q3g OH 4886 CH S Q1a a bond Me a bond NH S NH Q3h OH 4887CH S Q1b a bond Me a bond NH S NH Q3g OH 4888 CH S Q1b a bond Me a bondNH S NH Q3h OH 4889 CH S Q1c a bond Me a bond NH S NH Q3g OH 4890 CH SQ1c a bond Me a bond NH S NH Q3h OH 4891 CH O Q1a a bond Me a bond NH SNH Q3g OH 4892 CH O Q1a a bond Me a bond NH S NH Q3h OH 4893 CH O Q1b abond Me a bond NH S NH Q3g OH 4894 CH O Q1b a bond Me a bond NH S NH Q3hOH 4895 CH O Q1c a bond Me a bond NH S NH Q3g OH 4896 CH O Q1c a bond Mea bond NH S NH Q3h OH 4897 CMe NMe Q1a a bond Me a bond NH S NH Q3g OH4898 CMe NMe Q1a a bond Me a bond NH S NH Q3h OH 4899 CMe NMe Q1b a bondMe a bond NH S NH Q3g OH 4900 CMe NMe Q1b a bond Me a bond NH S NH Q3hOH 4901 CMe NMe Q1c a bond Me a bond NH S NH Q3g OH 4902 CMe NMe Q1c abond Me a bond NH S NH Q3h OH 4903 CMe NEt Q1a a bond Me a bond NH S NHQ3g OH 4904 CMe NEt Q1a a bond Me a bond NH S NH Q3h OH 4905 CMe NEt Q1ba bond Me a bond NH S NH Q3g OH 4906 CMe NEt Q1b a bond Me a bond NH SNH Q3h OH 4907 CMe NEt Q1c a bond Me a bond NH S NH Q3g OH 4908 CMe NEtQ1c a bond Me a bond NH S NH Q3h OH 4909 CMe S Q1a a bond Me a bond NH SNH Q3g OH 4910 CMe S Q1a a bond Me a bond NH S NH Q3h OH 4911 CMe S Q1ba bond Me a bond NH S NH Q3g OH 4912 CMe S Q1b a bond Me a bond NH S NHQ3h OH 4913 CMe S Q1c a bond Me a bond NH S NH Q3g OH 4914 CMe S Q1c abond Me a bond NH S NH Q3h OH 4915 CMe O Q1a a bond Me a bond NH S NHQ3g OH 4916 CMe O Q1a a bond Me a bond NH S NH Q3h OH 4917 CMe O Q1b abond Me a bond NH S NH Q3g OH 4918 CMe O Q1b a bond Me a bond NH S NHQ3h OH 4919 CMe O Q1c a bond Me a bond NH S NH Q3g OH 4920 CMe O Q1c abond Me a bond NH S NH Q3h OH 4921 N NMe Q1a a bond Me a bond NH O abond Q3g OH 4922 N NMe Q1a a bond Me a bond NH O a bond Q3h OH 4923 NNMe Q1b a bond Me a bond NH O a bond Q3g OH 4924 N NMe Q1b a bond Me abond NH O a bond Q3h OH 4925 N NMe Q1c a bond Me a bond NH O a bond Q3gOH 4926 N NMe Q1c a bond Me a bond NH O a bond Q3h OH 4927 N NEt Q1a abond Me a bond NH O a bond Q3g OH 4928 N NEt Q1a a bond Me a bond NH O abond Q3h OH 4929 N NEt Q1b a bond Me a bond NH O a bond Q3g OH 4930 NNEt Q1b a bond Me a bond NH O a bond Q3h OH 4931 N NEt Q1c a bond Me abond NH O a bond Q3g OH 4932 N NEt Q1c a bond Me a bond NH O a bond Q3hOH 4933 N S Q1a a bond Me a bond NH O a bond Q3g OH 4934 N S Q1a a bondMe a bond NH O a bond Q3h OH 4935 N S Q1b a bond Me a bond NH O a bondQ3g OH 4936 N S Q1b a bond Me a bond NH O a bond Q3h OH 4937 N S Q1c abond Me a bond NH O a bond Q3g OH 4938 N S Q1c a bond Me a bond NH O abond Q3h OH 4939 N O Q1a a bond Me a bond NH O a bond Q3g OH 4940 N OQ1a a bond Me a bond NH O a bond Q3h OH 4941 N O Q1b a bond Me a bond NHO a bond Q3g OH 4942 N O Q1b a bond Me a bond NH O a bond Q3h OH 4943 NO Q1c a bond Me a bond NH O a bond Q3g OH 4944 N O Q1c a bond Me a bondNH O a bond Q3h OH 4945 CH NMe Q1a a bond Me a bond NH O a bond Q3g OH4946 CH NMe Q1a a bond Me a bond NH O a bond Q3h OH 4947 CH NMe Q1b abond Me a bond NH O a bond Q3g OH 4948 CH NMe Q1b a bond Me a bond NH Oa bond Q3h OH 4949 CH NMe Q1c a bond Me a bond NH O a bond Q3g OH 4950CH NMe Q1c a bond Me a bond NH O a bond Q3h OH 4951 CH NEt Q1a a bond Mea bond NH O a bond Q3g OH 4952 CH NEt Q1a a bond Me a bond NH O a bondQ3h OH 4953 CH NEt Q1b a bond Me a bond NH O a bond Q3g OH 4954 CH NEtQ1b a bond Me a bond NH O a bond Q3h OH 4955 CH NEt Q1c a bond Me a bondNH O a bond Q3g OH 4956 CH NEt Q1c a bond Me a bond NH O a bond Q3h OH4957 CH S Q1a a bond Me a bond NH O a bond Q3g OH 4958 CH S Q1a a bondMe a bond NH O a bond Q3h OH 4959 CH S Q1b a bond Me a bond NH O a bondQ3g OH 4960 CH S Q1b a bond Me a bond NH O a bond Q3h OH 4961 CH S Q1c abond Me a bond NH O a bond Q3g OH 4962 CH S Q1c a bond Me a bond NH O abond Q3h OH 4963 CH O Q1a a bond Me a bond NH O a bond Q3g OH 4964 CH OQ1a a bond Me a bond NH O a bond Q3h OH 4965 CH O Q1b a bond Me a bondNH O a bond Q3g OH 4966 CH O Q1b a bond Me a bond NH O a bond Q3h OH4967 CH O Q1c a bond Me a bond NH O a bond Q3g OH 4968 CH O Q1c a bondMe a bond NH O a bond Q3h OH 4969 CMe NMe Q1a a bond Me a bond NH O abond Q3g OH 4970 CMe NMe Q1a a bond Me a bond NH O a bond Q3h OH 4971CMe NMe Q1b a bond Me a bond NH O a bond Q3g OH 4972 CMe NMe Q1b a bondMe a bond NH O a bond Q3h OH 4973 CMe NMe Q1c a bond Me a bond NH O abond Q3g OH 4974 CMe NMe Q1c a bond Me a bond NH O a bond Q3h OH 4975CMe NEt Q1a a bond Me a bond NH O a bond Q3g OH 4976 CMe NEt Q1a a bondMe a bond NH O a bond Q3h OH 4977 CMe NEt Q1b a bond Me a bond NH O abond Q3g OH 4978 CMe NEt Q1b a bond Me a bond NH O a bond Q3h OH 4979CMe NEt Q1c a bond Me a bond NH O a bond Q3g OH 4980 CMe NEt Q1c a bondMe a bond NH O a bond Q3h OH 4981 CMe S Q1a a bond Me a bond NH O a bondQ3g OH 4982 CMe S Q1a a bond Me a bond NH O a bond Q3h OH 4983 CMe S Q1ba bond Me a bond NH O a bond Q3g OH 4984 CMe S Q1b a bond Me a bond NH Oa bond Q3h OH 4985 CMe S Q1c a bond Me a bond NH O a bond Q3g OH 4986CMe S Q1c a bond Me a bond NH O a bond Q3h OH 4987 CMe O Q1a a bond Me abond NH O a bond Q3g OH 4988 CMe O Q1a a bond Me a bond NH O a bond Q3hOH 4989 CMe O Q1b a bond Me a bond NH O a bond Q3g OH 4990 CMe O Q1b abond Me a bond NH O a bond Q3h OH 4991 CMe O Q1c a bond Me a bond NH O abond Q3g OH 4992 CMe O Q1c a bond Me a bond NH O a bond Q3h OH 4992 CMeO Q1c a bond Me a bond NH O a bond Q3h OH 4993 CH NH Q1a a bond Me abond NH S NH Q3a OH 4994 CH NH Q1a a bond Me a bond NH S NH Q3b OH 4995CH NH Q1a a bond Me a bond NH S NH Q3c OH 4996 CH NH Q1a a bond Me abond NH S a bond Q3a OH 4997 CH NH Q1a a bond Me a bond NH S a bond Q3bOH 4998 CH NH Q1a a bond Me a bond NH S a bond Q3c OH 4999 CH NH Q1a abond Me a bond NH O NH Q3a OH 5000 CH NH Q1a a bond Me a bond NH O NHQ3b OH 5001 CH NH Q1a a bond Me a bond NH O NH Q3c OH 5002 CH NH Q1a abond Me a bond NH O a bond Q3a OH 5003 CH NH Q1a a bond Me a bond NH O abond Q3b OH 5004 CH NH Q1a a bond Me a bond NH O a bond Q3c OH 5005 CHNH Q1a a bond H a bond NH S NH Q3a OH 5006 CH NH Q1a a bond H a bond NHS NH Q3b OH 5007 CH NH Q1a a bond H a bond NH S NH Q3c OH 5008 CH NH Q1aa bond H a bond NH S a bond Q3a OH 5009 CH NH Q1a a bond H a bond NH S abond Q3b OH 5010 CH NH Q1a a bond H a bond NH S a bond Q3c OH 5011 CH NHQ1a a bond H a bond NH O NH Q3a OH 5012 CH NH Q1a a bond H a bond NH ONH Q3b OH 5013 CH NH Q1a a bond H a bond NH O NH Q3c OH 5014 CH NH Q1a abond H a bond NH O a bond Q3a OH 5015 CH NH Q1a a bond H a bond NH O abond Q3b OH 5016 CH NH Q1a a bond H a bond NH O a bond Q3c OH 5017 CH NHQ1b a bond Me a bond NH S NH Q3a OH 5018 CH NH Q1b a bond Me a bond NH SNH Q3b OH 5019 CH NH Q1b a bond Me a bond NH S NH Q3c OH 5020 CH NH Q1ba bond Me a bond NH S a bond Q3a OH 5021 CH NH Q1b a bond Me a bond NH Sa bond Q3b OH 5022 CH NH Q1b a bond Me a bond NH S a bond Q3c OH 5023 CHNH Q1b a bond Me a bond NH O NH Q3a OH 5024 CH NH Q1b a bond Me a bondNH O NH Q3b OH 5025 CH NH Q1b a bond Me a bond NH O NH Q3c OH 5026 CH NHQ1b a bond Me a bond NH O a bond Q3a OH 5027 CH NH Q1b a bond Me a bondNH O a bond Q3b OH 5028 CH NH Q1b a bond Me a bond NH O a bond Q3c OH5029 CH NH Q1b a bond H a bond NH S NH Q3a OH 5030 CH NH Q1b a bond H abond NH S NH Q3b OH 5031 CH NH Q1b a bond H a bond NH S NH Q3c OH 5032CH NH Q1b a bond H a bond NH S a bond Q3a OH 5033 CH NH Q1b a bond H abond NH S a bond Q3b OH 5034 CH NH Q1b a bond H a bond NH S a bond Q3cOH 5035 CH NH Q1b a bond H a bond NH O NH Q3a OH 5036 CH NH Q1b a bond Ha bond NH O NH Q3b OH 5037 CH NH Q1b a bond H a bond NH O NH Q3c OH 5038CH NH Q1b a bond H a bond NH O a bond Q3a OH 5039 CH NH Q1b a bond H abond NH O a bond Q3b OH 5040 CH NH Q1b a bond H a bond NH O a bond Q3cOH 5041 CH NH Q1c a bond Me a bond NH S NH Q3a OH 5042 CH NH Q1c a bondMe a bond NH S NH Q3b OH 5043 CH NH Q1c a bond Me a bond NH S NH Q3c OH5044 CH NH Q1c a bond Me a bond NH S a bond Q3a OH 5045 CH NH Q1c a bondMe a bond NH S a bond Q3b OH 5046 CH NH Q1c a bond Me a bond NH S a bondQ3c OH 5047 CH NH Q1c a bond Me a bond NH O NH Q3a OH 5048 CH NH Q1c abond Me a bond NH O NH Q3b OH 5049 CH NH Q1c a bond Me a bond NH O NHQ3c OH 5050 CH NH Q1c a bond Me a bond NH O a bond Q3a OH 5051 CH NH Q1ca bond Me a bond NH O a bond Q3b OH 5052 CH NH Q1c a bond Me a bond NH Oa bond Q3c OH 5053 CH NH Q1c a bond H a bond NH S NH Q3a OH 5054 CH NHQ1c a bond H a bond NH S NH Q3b OH 5055 CH NH Q1c a bond H a bond NH SNH Q3c OH 5056 CH NH Q1c a bond H a bond NH S a bond Q3a OH 5057 CH NHQ1c a bond H a bond NH S a bond Q3b OH 5058 CH NH Q1c a bond H a bond NHS a bond Q3c OH 5059 CH NH Q1c a bond H a bond NH O NH Q3a OH 5060 CH NHQ1c a bond H a bond NH O NH Q3b OH 5061 CH NH Q1c a bond H a bond NH ONH Q3c OH 5062 CH NH Q1c a bond H a bond NH O a bond Q3a OH 5063 CH NHQ1c a bond H a bond NH O a bond Q3b OH 5064 CH NH Q1c a bond H a bond NHO a bond Q3c OH 5065 CH NH Q1d a bond Me a bond NH S NH Q3a OH 5066 CHNH Q1d a bond Me a bond NH S NH Q3b OH 5067 CH NH Q1d a bond Me a bondNH S NH Q3c OH 5068 CH NH Q1d a bond Me a bond NH S a bond Q3a OH 5069CH NH Q1d a bond Me a bond NH S a bond Q3b OH 5070 CH NH Q1d a bond Me abond NH S a bond Q3c OH 5071 CH NH Q1d a bond Me a bond NH O NH Q3a OH5072 CH NH Q1d a bond Me a bond NH O NH Q3b OH 5073 CH NH Q1d a bond Mea bond NH O NH Q3c OH 5074 CH NH Q1d a bond Me a bond NH O a bond Q3a OH5075 CH NH Q1d a bond Me a bond NH O a bond Q3b OH 5076 CH NH Q1d a bondMe a bond NH O a bond Q3c OH 5077 CH NH Q1d a bond H a bond NH S NH Q3aOH 5078 CH NH Q1d a bond H a bond NH S NH Q3b OH 5079 CH NH Q1d a bond Ha bond NH S NH Q3c OH 5080 CH NH Q1d a bond H a bond NH S a bond Q3a OH5081 CH NH Q1d a bond H a bond NH S a bond Q3b OH 5082 CH NH Q1d a bondH a bond NH S a bond Q3c OH 5083 CH NH Q1d a bond H a bond NH O NH Q3aOH 5084 CH NH Q1d a bond H a bond NH O NH Q3b OH 5085 CH NH Q1d a bond Ha bond NH O NH Q3c OH 5086 CH NH Q1d a bond H a bond NH O a bond Q3a OH5087 CH NH Q1d a bond H a bond NH O a bond Q3b OH 5088 CH NH Q1d a bondH a bond NH O a bond Q3c OH 5089 CH NH Q1e a bond Me a bond NH S NH Q3aOH 5090 CH NH Q1e a bond Me a bond NH S NH Q3b OH 5091 CH NH Q1e a bondMe a bond NH S NH Q3c OH 5092 CH NH Q1e a bond Me a bond NH S a bond Q3aOH 5093 CH NH Q1e a bond Me a bond NH S a bond Q3b OH 5094 CH NH Q1e abond Me a bond NH S a bond Q3c OH 5095 CH NH Q1e a bond Me a bond NH ONH Q3a OH 5096 CH NH Q1e a bond Me a bond NH O NH Q3b OH 5097 CH NH Q1ea bond Me a bond NH O NH Q3c OH 5098 CH NH Q1e a bond Me a bond NH O abond Q3a OH 5099 CH NH Q1e a bond Me a bond NH O a bond Q3b OH 5100 CHNH Q1e a bond Me a bond NH O a bond Q3c OH 5101 CH NH Q1e a bond H abond NH S NH Q3a OH 5102 CH NH Q1e a bond H a bond NH S NH Q3b OH 5103CH NH Q1e a bond H a bond NH S NH Q3c OH 5104 CH NH Q1e a bond H a bondNH S a bond Q3a OH 5105 CH NH Q1e a bond H a bond NH S a bond Q3b OH5106 CH NH Q1e a bond H a bond NH S a bond Q3c OH 5107 CH NH Q1e a bondH a bond NH O NH Q3a OH 5108 CH NH Q1e a bond H a bond NH O NH Q3b OH5109 CH NH Q1e a bond H a bond NH O NH Q3c OH 5110 CH NH Q1e a bond H abond NH O a bond Q3a OH 5111 CH NH Q1e a bond H a bond NH O a bond Q3bOH 5112 CH NH Q1e a bond H a bond NH O a bond Q3c OH 5113 CH NH Q1f abond Me a bond NH S NH Q3a OH 5114 CH NH Q1f a bond Me a bond NH S NHQ3b OH 5115 CH NH Q1f a bond Me a bond NH S NH Q3c OH 5116 CH NH Q1f abond Me a bond NH S a bond Q3a OH 5117 CH NH Q1f a bond Me a bond NH S abond Q3b OH 5118 CH NH Q1f a bond Me a bond NH S a bond Q3c OH 5119 CHNH Q1f a bond Me a bond NH O NH Q3a OH 5120 CH NH Q1f a bond Me a bondNH O NH Q3b OH 5121 CH NH Q1f a bond Me a bond NH O NH Q3c OH 5122 CH NHQ1f a bond Me a bond NH O a bond Q3a OH 5123 CH NH Q1f a bond Me a bondNH O a bond Q3b OH 5124 CH NH Q1f a bond Me a bond NH O a bond Q3c OH5125 CH NH Q1f a bond H a bond NH S NH Q3a OH 5126 CH NH Q1f a bond H abond NH S NH Q3b OH 5127 CH NH Q1f a bond H a bond NH S NH Q3c OH 5128CH NH Q1f a bond H a bond NH S a bond Q3a OH 5129 CH NH Q1f a bond H abond NH S a bond Q3b OH 5130 CH NH Q1f a bond H a bond NH S a bond Q3cOH 5131 CH NH Q1f a bond H a bond NH O NH Q3a OH 5132 CH NH Q1f a bond Ha bond NH O NH Q3b OH 5133 CH NH Q1f a bond H a bond NH O NH Q3c OH 5134CH NH Q1f a bond H a bond NH O a bond Q3a OH 5135 CH NH Q1f a bond H abond NH O a bond Q3b OH 5136 CH NH Q1f a bond H a bond NH O a bond Q3cOH 5137 CH NH Q1g a bond Me a bond NH S NH Q3a OH 5138 CH NH Q1g a bondMe a bond NH S NH Q3b OH 5139 CH NH Q1g a bond Me a bond NH S NH Q3c OH5140 CH NH Q1g a bond Me a bond NH S a bond Q3a OH 5141 CH NH Q1g a bondMe a bond NH S a bond Q3b OH 5142 CH NH Q1g a bond Me a bond NH S a bondQ3c OH 5143 CH NH Q1g a bond Me a bond NH O NH Q3a OH 5144 CH NH Q1g abond Me a bond NH O NH Q3b OH 5145 CH NH Q1g a bond Me a bond NH O NHQ3c OH 5146 CH NH Q1g a bond Me a bond NH O a bond Q3a OH 5147 CH NH Q1ga bond Me a bond NH O a bond Q3b OH 5148 CH NH Q1g a bond Me a bond NH Oa bond Q3c OH 5149 CH NH Q1g a bond H a bond NH S NH Q3a OH 5150 CH NHQ1g a bond H a bond NH S NH Q3b OH 5151 CH NH Q1g a bond H a bond NH SNH Q3c OH 5152 CH NH Q1g a bond H a bond NH S a bond Q3a OH 5153 CH NHQ1g a bond H a bond NH S a bond Q3b OH 5154 CH NH Q1g a bond H a bond NHS a bond Q3c OH 5155 CH NH Q1g a bond H a bond NH O NH Q3a OH 5156 CH NHQ1g a bond H a bond NH O NH Q3b OH 5157 CH NH Q1g a bond H a bond NH ONH Q3c OH 5158 CH NH Q1g a bond H a bond NH O a bond Q3a OH 5159 CH NHQ1g a bond H a bond NH O a bond Q3b OH 5160 CH NH Q1g a bond H a bond NHO a bond Q3c OH 5161 CH NH Q1h a bond Me a bond NH S NH Q3a OH 5162 CHNH Q1h a bond Me a bond NH S NH Q3b OH 5163 CH NH Q1h a bond Me a bondNH S NH Q3c OH 5164 CH NH Q1h a bond Me a bond NH S a bond Q3a OH 5165CH NH Q1h a bond Me a bond NH S a bond Q3b OH 5166 CH NH Q1h a bond Me abond NH S a bond Q3c OH 5167 CH NH Q1h a bond Me a bond NH O NH Q3a OH5168 CH NH Q1h a bond Me a bond NH O NH Q3b OH 5169 CH NH Q1h a bond Mea bond NH O NH Q3c OH 5170 CH NH Q1h a bond Me a bond NH O a bond Q3a OH5171 CH NH Q1h a bond Me a bond NH O a bond Q3b OH 5172 CH NH Q1h a bondMe a bond NH O a bond Q3c OH 5173 CH NH Q1h a bond H a bond NH S NH Q3aOH 5174 CH NH Q1h a bond H a bond NH S NH Q3b OH 5175 CH NH Q1h a bond Ha bond NH S NH Q3c OH 5176 CH NH Q1h a bond H a bond NH S a bond Q3a OH5177 CH NH Q1h a bond H a bond NH S a bond Q3b OH 5178 CH NH Q1h a bondH a bond NH S a bond Q3c OH 5179 CH NH Q1h a bond H a bond NH O NH Q3aOH 5180 CH NH Q1h a bond H a bond NH O NH Q3b OH 5181 CH NH Q1h a bond Ha bond NH O NH Q3c OH 5182 CH NH Q1h a bond H a bond NH O a bond Q3a OH5183 CH NH Q1h a bond H a bond NH O a bond Q3b OH 5184 CH NH Q1h a bondH a bond NH O a bond Q3c OH 5185 CH NH Q1i a bond Me a bond NH S NH Q3aOH 5186 CH NH Q1i a bond Me a bond NH S NH Q3b OH 5187 CH NH Q1i a bondMe a bond NH S NH Q3c OH 5188 CH NH Q1i a bond Me a bond NH S a bond Q3aOH 5189 CH NH Q1i a bond Me a bond NH S a bond Q3b OH 5190 CH NH Q1i abond Me a bond NH S a bond Q3c OH 5191 CH NH Q1i a bond Me a bond NH ONH Q3a OH 5192 CH NH Q1i a bond Me a bond NH O NH Q3b OH 5193 CH NH Q1ia bond Me a bond NH O NH Q3c OH 5194 CH NH Q1i a bond Me a bond NH O abond Q3a OH 5195 CH NH Q1i a bond Me a bond NH O a bond Q3b OH 5196 CHNH Q1i a bond Me a bond NH O a bond Q3c OH 5197 CH NH Q1i a bond H abond NH S NH Q3a OH 5198 CH NH Q1i a bond H a bond NH S NH Q3b OH 5199CH NH Q1i a bond H a bond NH S NH Q3c OH 5200 CH NH Q1i a bond H a bondNH S a bond Q3a OH 5201 CH NH Q1i a bond H a bond NH S a bond Q3b OH5202 CH NH Q1i a bond H a bond NH S a bond Q3c OH 5203 CH NH Q1i a bondH a bond NH O NH Q3a OH 5204 CH NH Q1i a bond H a bond NH O NH Q3b OH5205 CH NH Q1i a bond H a bond NH O NH Q3c OH 5206 CH NH Q1i a bond H abond NH O a bond Q3a OH 5207 CH NH Q1i a bond H a bond NH O a bond Q3bOH 5208 CH NH Q1i a bond H a bond NH O a bond Q3c OH 5209 CH NH Q1j abond Me a bond NH S NH Q3a OH 5210 CH NH Q1j a bond Me a bond NH S NHQ3b OH 5211 CH NH Q1j a bond Me a bond NH S NH Q3c OH 5212 CH NH Q1j abond Me a bond NH S a bond Q3a OH 5213 CH NH Q1j a bond Me a bond NH S abond Q3b OH 5214 CH NH Q1j a bond Me a bond NH S a bond Q3c OH 5215 CHNH Q1j a bond Me a bond NH O NH Q3a OH 5216 CH NH Q1j a bond Me a bondNH O NH Q3b OH 5217 CH NH Q1j a bond Me a bond NH O NH Q3c OH 5218 CH NHQ1j a bond Me a bond NH O a bond Q3a OH 5219 CH NH Q1j a bond Me a bondNH O a bond Q3b OH 5220 CH NH Q1j a bond Me a bond NH O a bond Q3c OH5221 CH NH Q1j a bond H a bond NH S NH Q3a OH 5222 CH NH Q1j a bond H abond NH S NH Q3b OH 5223 CH NH Q1j a bond H a bond NH S NH Q3c OH 5224CH NH Q1j a bond H a bond NH S a bond Q3a OH 5225 CH NH Q1j a bond H abond NH S a bond Q3b OH 5226 CH NH Q1j a bond H a bond NH S a bond Q3cOH 5227 CH NH Q1j a bond H a bond NH O NH Q3a OH 5228 CH NH Q1j a bond Ha bond NH O NH Q3b OH 5229 CH NH Q1j a bond H a bond NH O NH Q3c OH 5230CH NH Q1j a bond H a bond NH O a bond Q3a OH 5231 CH NH Q1j a bond H abond NH O a bond Q3b OH 5232 CH NH Q1j a bond H a bond NH O a bond Q3cOH 5233 CMe NH Q1a a bond Me a bond NH S NH Q3a OH 5234 CMe NH Q1a abond Me a bond NH S NH Q3b OH 5235 CMe NH Q1a a bond Me a bond NH S NHQ3c OH 5236 CMe NH Q1a a bond Me a bond NH S a bond Q3a OH 5237 CMe NHQ1a a bond Me a bond NH S a bond Q3b OH 5238 CMe NH Q1a a bond Me a bondNH S a bond Q3c OH 5239 CMe NH Q1a a bond Me a bond NH O NH Q3a OH 5240CMe NH Q1a a bond Me a bond NH O NH Q3b OH 5241 CMe NH Q1a a bond Me abond NH O NH Q3c OH 5242 CMe NH Q1a a bond Me a bond NH O a bond Q3a OH5243 CMe NH Q1a a bond Me a bond NH O a bond Q3b OH 5244 CMe NH Q1a abond Me a bond NH O a bond Q3c OH 5245 CMe NH Q1a a bond H a bond NH SNH Q3a OH 5246 CMe NH Q1a a bond H a bond NH S NH Q3b OH 5247 CMe NH Q1aa bond H a bond NH S NH Q3c OH 5248 CMe NH Q1a a bond H a bond NH S abond Q3a OH 5249 CMe NH Q1a a bond H a bond NH S a bond Q3b OH 5250 CMeNH Q1a a bond H a bond NH S a bond Q3c OH 5251 CMe NH Q1a a bond H abond NH O NH Q3a OH 5252 CMe NH Q1a a bond H a bond NH O NH Q3b OH 5253CMe NH Q1a a bond H a bond NH O NH Q3c OH 5254 CMe NH Q1a a bond H abond NH O a bond Q3a OH 5255 CMe NH Q1a a bond H a bond NH O a bond Q3bOH 5256 CMe NH Q1a a bond H a bond NH O a bond Q3c OH 5257 CMe NH Q1b abond Me a bond NH S NH Q3a OH 5258 CMe NH Q1b a bond Me a bond NH S NHQ3b OH 5259 CMe NH Q1b a bond Me a bond NH S NH Q3c OH 5260 CMe NH Q1b abond Me a bond NH S a bond Q3a OH 5261 CMe NH Q1b a bond Me a bond NH Sa bond Q3b OH 5262 CMe NH Q1b a bond Me a bond NH S a bond Q3c OH 5263CMe NH Q1b a bond Me a bond NH O NH Q3a OH 5264 CMe NH Q1b a bond Me abond NH O NH Q3b OH 5265 CMe NH Q1b a bond Me a bond NH O NH Q3c OH 5266CMe NH Q1b a bond Me a bond NH O a bond Q3a OH 5267 CMe NH Q1b a bond Mea bond NH O a bond Q3b OH 5268 CMe NH Q1b a bond Me a bond NH O a bondQ3c OH 5269 CMe NH Q1b a bond H a bond NH S NH Q3a OH 5270 CMe NH Q1b abond H a bond NH S NH Q3b OH 5271 CMe NH Q1b a bond H a bond NH S NH Q3cOH 5272 CMe NH Q1b a bond H a bond NH S a bond Q3a OH 5273 CMe NH Q1b abond H a bond NH S a bond Q3b OH 5274 CMe NH Q1b a bond H a bond NH S abond Q3c OH 5275 CMe NH Q1b a bond H a bond NH O NH Q3a OH 5276 CMe NHQ1b a bond H a bond NH O NH Q3b OH 5277 CMe NH Q1b a bond H a bond NH ONH Q3c OH 5278 CMe NH Q1b a bond H a bond NH O a bond Q3a OH 5279 CMe NHQ1b a bond H a bond NH O a bond Q3b OH 5280 CMe NH Q1b a bond H a bondNH O a bond Q3c OH 5281 CMe NH Q1c a bond Me a bond NH S NH Q3a OH 5282CMe NH Q1c a bond Me a bond NH S NH Q3b OH 5283 CMe NH Q1c a bond Me abond NH S NH Q3c OH 5284 CMe NH Q1c a bond Me a bond NH S a bond Q3a OH5285 CMe NH Q1c a bond Me a bond NH S a bond Q3b OH 5286 CMe NH Q1c abond Me a bond NH S a bond Q3c OH 5287 CMe NH Q1c a bond Me a bond NH ONH Q3a OH 5288 CMe NH Q1c a bond Me a bond NH O NH Q3b OH 5289 CMe NHQ1c a bond Me a bond NH O NH Q3c OH 5290 CMe NH Q1c a bond Me a bond NHO a bond Q3a OH 5291 CMe NH Q1c a bond Me a bond NH O a bond Q3b OH 5292CMe NH Q1c a bond Me a bond NH O a bond Q3c OH 5293 CMe NH Q1c a bond Ha bond NH S NH Q3a OH 5294 CMe NH Q1c a bond H a bond NH S NH Q3b OH5295 CMe NH Q1c a bond H a bond NH S NH Q3c OH 5296 CMe NH Q1c a bond Ha bond NH S a bond Q3a OH 5297 CMe NH Q1c a bond H a bond NH S a bondQ3b OH 5298 CMe NH Q1c a bond H a bond NH S a bond Q3c OH 5299 CMe NHQ1c a bond H a bond NH O NH Q3a OH 5300 CMe NH Q1c a bond H a bond NH ONH Q3b OH 5301 CMe NH Q1c a bond H a bond NH O NH Q3c OH 5302 CMe NH Q1ca bond H a bond NH O a bond Q3a OH 5303 CMe NH Q1c a bond H a bond NH Oa bond Q3b OH 5304 CMe NH Q1c a bond H a bond NH O a bond Q3c OH 5305CMe NH Q1d a bond Me a bond NH S NH Q3a OH 5306 CMe NH Q1d a bond Me abond NH S NH Q3b OH 5307 CMe NH Q1d a bond Me a bond NH S NH Q3c OH 5308CMe NH Q1d a bond Me a bond NH S a bond Q3a OH 5309 CMe NH Q1d a bond Mea bond NH S a bond Q3b OH 5310 CMe NH Q1d a bond Me a bond NH S a bondQ3c OH 5311 CMe NH Q1d a bond Me a bond NH O NH Q3a OH 5312 CMe NH Q1d abond Me a bond NH O NH Q3b OH 5313 CMe NH Q1d a bond Me a bond NH O NHQ3c OH 5314 CMe NH Q1d a bond Me a bond NH O a bond Q3a OH 5315 CMe NHQ1d a bond Me a bond NH O a bond Q3b OH 5316 CMe NH Q1d a bond Me a bondNH O a bond Q3c OH 5317 CMe NH Q1d a bond H a bond NH S NH Q3a OH 5318CMe NH Q1d a bond H a bond NH S NH Q3b OH 5319 CMe NH Q1d a bond H abond NH S NH Q3c OH 5320 CMe NH Q1d a bond H a bond NH S a bond Q3a OH5321 CMe NH Q1d a bond H a bond NH S a bond Q3b OH 5322 CMe NH Q1d abond H a bond NH S a bond Q3c OH 5323 CMe NH Q1d a bond H a bond NH O NHQ3a OH 5324 CMe NH Q1d a bond H a bond NH O NH Q3b OH 5325 CMe NH Q1d abond H a bond NH O NH Q3c OH 5326 CMe NH Q1d a bond H a bond NH O a bondQ3a OH 5327 CMe NH Q1d a bond H a bond NH O a bond Q3b OH 5328 CMe NHQ1d a bond H a bond NH O a bond Q3c OH 5329 CMe NH Q1e a bond Me a bondNH S NH Q3a OH 5330 CMe NH Q1e a bond Me a bond NH S NH Q3b OH 5331 CMeNH Q1e a bond Me a bond NH S NH Q3c OH 5332 CMe NH Q1e a bond Me a bondNH S a bond Q3a OH 5333 CMe NH Q1e a bond Me a bond NH S a bond Q3b OH5334 CMe NH Q1e a bond Me a bond NH S a bond Q3c OH 5335 CMe NH Q1e abond Me a bond NH O NH Q3a OH 5336 CMe NH Q1e a bond Me a bond NH O NHQ3b OH 5337 CMe NH Q1e a bond Me a bond NH O NH Q3c OH 5338 CMe NH Q1e abond Me a bond NH O a bond Q3a OH 5339 CMe NH Q1e a bond Me a bond NH Oa bond Q3b OH 5340 CMe NH Q1e a bond Me a bond NH O a bond Q3c OH 5341CMe NH Q1e a bond H a bond NH S NH Q3a OH 5342 CMe NH Q1e a bond H abond NH S NH Q3b OH 5343 CMe NH Q1e a bond H a bond NH S NH Q3c OH 5344CMe NH Q1e a bond H a bond NH S a bond Q3a OH 5345 CMe NH Q1e a bond H abond NH S a bond Q3b OH 5346 CMe NH Q1e a bond H a bond NH S a bond Q3cOH 5347 CMe NH Q1e a bond H a bond NH O NH Q3a OH 5348 CMe NH Q1e a bondH a bond NH O NH Q3b OH 5349 CMe NH Q1e a bond H a bond NH O NH Q3c OH5350 CMe NH Q1e a bond H a bond NH O a bond Q3a OH 5351 CMe NH Q1e abond H a bond NH O a bond Q3b OH 5352 CMe NH Q1e a bond H a bond NH O abond Q3c OH 5353 CMe NH Q1f a bond Me a bond NH S NH Q3a OH 5354 CMe NHQ1f a bond Me a bond NH S NH Q3b OH 5355 CMe NH Q1f a bond Me a bond NHS NH Q3c OH 5356 CMe NH Q1f a bond Me a bond NH S a bond Q3a OH 5357 CMeNH Q1f a bond Me a bond NH S a bond Q3b OH 5358 CMe NH Q1f a bond Me abond NH S a bond Q3c OH 5359 CMe NH Q1f a bond Me a bond NH O NH Q3a OH5360 CMe NH Q1f a bond Me a bond NH O NH Q3b OH 5361 CMe NH Q1f a bondMe a bond NH O NH Q3c OH 5362 CMe NH Q1f a bond Me a bond NH O a bondQ3a OH 5363 CMe NH Q1f a bond Me a bond NH O a bond Q3b OH 5364 CMe NHQ1f a bond Me a bond NH O a bond Q3c OH 5365 CMe NH Q1f a bond H a bondNH S NH Q3a OH 5366 CMe NH Q1f a bond H a bond NH S NH Q3b OH 5367 CMeNH Q1f a bond H a bond NH S NH Q3c OH 5368 CMe NH Q1f a bond H a bond NHS a bond Q3a OH 5369 CMe NH Q1f a bond H a bond NH S a bond Q3b OH 5370CMe NH Q1f a bond H a bond NH S a bond Q3c OH 5371 CMe NH Q1f a bond H abond NH O NH Q3a OH 5372 CMe NH Q1f a bond H a bond NH O NH Q3b OH 5373CMe NH Q1f a bond H a bond NH O NH Q3c OH 5374 CMe NH Q1f a bond H abond NH O a bond Q3a OH 5375 CMe NH Q1f a bond H a bond NH O a bond Q3bOH 5376 CMe NH Q1f a bond H a bond NH O a bond Q3c OH 5377 CMe NH Q1g abond Me a bond NH S NH Q3a OH 5378 CMe NH Q1g a bond Me a bond NH S NHQ3b OH 5379 CMe NH Q1g a bond Me a bond NH S NH Q3c OH 5380 CMe NH Q1g abond Me a bond NH S a bond Q3a OH 5381 CMe NH Q1g a bond Me a bond NH Sa bond Q3b OH 5382 CMe NH Q1g a bond Me a bond NH S a bond Q3c OH 5383CMe NH Q1g a bond Me a bond NH O NH Q3a OH 5384 CMe NH Q1g a bond Me abond NH O NH Q3b OH 5385 CMe NH Q1g a bond Me a bond NH O NH Q3c OH 5386CMe NH Q1g a bond Me a bond NH O a bond Q3a OH 5387 CMe NH Q1g a bond Mea bond NH O a bond Q3b OH 5388 CMe NH Q1g a bond Me a bond NH O a bondQ3c OH 5389 CMe NH Q1g a bond H a bond NH S NH Q3a OH 5390 CMe NH Q1g abond H a bond NH S NH Q3b OH 5391 CMe NH Q1g a bond H a bond NH S NH Q3cOH 5392 CMe NH Q1g a bond H a bond NH S a bond Q3a OH 5393 CMe NH Q1g abond H a bond NH S a bond Q3b OH 5394 CMe NH Q1g a bond H a bond NH S abond Q3c OH 5395 CMe NH Q1g a bond H a bond NH O NH Q3a OH 5396 CMe NHQ1g a bond H a bond NH O NH Q3b OH 5397 CMe NH Q1g a bond H a bond NH ONH Q3c OH 5398 CMe NH Q1g a bond H a bond NH O a bond Q3a OH 5399 CMe NHQ1g a bond H a bond NH O a bond Q3b OH 5400 CMe NH Q1g a bond H a bondNH O a bond Q3c OH 5401 CMe NH Q1h a bond Me a bond NH S NH Q3a OH 5402CMe NH Q1h a bond Me a bond NH S NH Q3b OH 5403 CMe NH Q1h a bond Me abond NH S NH Q3c OH 5404 CMe NH Q1h a bond Me a bond NH S a bond Q3a OH5405 CMe NH Q1h a bond Me a bond NH S a bond Q3b OH 5406 CMe NH Q1h abond Me a bond NH S a bond Q3c OH 5407 CMe NH Q1h a bond Me a bond NH ONH Q3a OH 5408 CMe NH Q1h a bond Me a bond NH O NH Q3b OH 5409 CMe NHQ1h a bond Me a bond NH O NH Q3c OH 5410 CMe NH Q1h a bond Me a bond NHO a bond Q3a OH 5411 CMe NH Q1h a bond Me a bond NH O a bond Q3b OH 5412CMe NH Q1h a bond Me a bond NH O a bond Q3c OH 5413 CMe NH Q1h a bond Ha bond NH S NH Q3a OH 5414 CMe NH Q1h a bond H a bond NH S NH Q3b OH5415 CMe NH Q1h a bond H a bond NH S NH Q3c OH 5416 CMe NH Q1h a bond Ha bond NH S a bond Q3a OH 5417 CMe NH Q1h a bond H a bond NH S a bondQ3b OH 5418 CMe NH Q1h a bond H a bond NH S a bond Q3c OH 5419 CMe NHQ1h a bond H a bond NH O NH Q3a OH 5420 CMe NH Q1h a bond H a bond NH ONH Q3b OH 5421 CMe NH Q1h a bond H a bond NH O NH Q3c OH 5422 CMe NH Q1ha bond H a bond NH O a bond Q3a OH 5423 CMe NH Q1h a bond H a bond NH Oa bond Q3b OH 5424 CMe NH Q1h a bond H a bond NH O a bond Q3c OH 5425CMe NH Q1i a bond Me a bond NH S NH Q3a OH 5426 CMe NH Q1i a bond Me abond NH S NH Q3b OH 5427 CMe NH Q1i a bond Me a bond NH S NH Q3c OH 5428CMe NH Q1i a bond Me a bond NH S a bond Q3a OH 5429 CMe NH Q1i a bond Mea bond NH S a bond Q3b OH 5430 CMe NH Q1i a bond Me a bond NH S a bondQ3c OH 5431 CMe NH Q1i a bond Me a bond NH O NH Q3a OH 5432 CMe NH Q1i abond Me a bond NH O NH Q3b OH 5433 CMe NH Q1i a bond Me a bond NH O NHQ3c OH 5434 CMe NH Q1i a bond Me a bond NH O a bond Q3a OH 5435 CMe NHQ1i a bond Me a bond NH O a bond Q3b OH 5436 CMe NH Q1i a bond Me a bondNH O a bond Q3c OH 5437 CMe NH Q1i a bond H a bond NH S NH Q3a OH 5438CMe NH Q1i a bond H a bond NH S NH Q3b OH 5439 CMe NH Q1i a bond H abond NH S NH Q3c OH 5440 CMe NH Q1i a bond H a bond NH S a bond Q3a OH5441 CMe NH Q1i a bond H a bond NH S a bond Q3b OH 5442 CMe NH Q1i abond H a bond NH S a bond Q3c OH 5443 CMe NH Q1i a bond H a bond NH O NHQ3a OH 5444 CMe NH Q1i a bond H a bond NH O NH Q3b OH 5445 CMe NH Q1i abond H a bond NH O NH Q3c OH 5446 CMe NH Q1i a bond H a bond NH O a bondQ3a OH 5447 CMe NH Q1i a bond H a bond NH O a bond Q3b OH 5448 CMe NHQ1i a bond H a bond NH O a bond Q3c OH 5449 CMe NH Q1j a bond Me a bondNH S NH Q3a OH 5450 CMe NH Q1j a bond Me a bond NH S NH Q3b OH 5451 CMeNH Q1j a bond Me a bond NH S NH Q3c OH 5452 CMe NH Q1j a bond Me a bondNH S a bond Q3a OH 5453 CMe NH Q1j a bond Me a bond NH S a bond Q3b OH5454 CMe NH Q1j a bond Me a bond NH S a bond Q3c OH 5455 CMe NH Q1j abond Me a bond NH O NH Q3a OH 5456 CMe NH Q1j a bond Me a bond NH O NHQ3b OH 5457 CMe NH Q1j a bond Me a bond NH O NH Q3c OH 5458 CMe NH Q1j abond Me a bond NH O a bond Q3a OH 5459 CMe NH Q1j a bond Me a bond NH Oa bond Q3b OH 5460 CMe NH Q1j a bond Me a bond NH O a bond Q3c OH 5461CMe NH Q1j a bond H a bond NH S NH Q3a OH 5462 CMe NH Q1j a bond H abond NH S NH Q3b OH 5463 CMe NH Q1j a bond H a bond NH S NH Q3c OH 5464CMe NH Q1j a bond H a bond NH S a bond Q3a OH 5465 CMe NH Q1j a bond H abond NH S a bond Q3b OH 5466 CMe NH Q1j a bond H a bond NH S a bond Q3cOH 5467 CMe NH Q1j a bond H a bond NH O NH Q3a OH 5468 CMe NH Q1j a bondH a bond NH O NH Q3b OH 5469 CMe NH Q1j a bond H a bond NH O NH Q3c OH5470 CMe NH Q1j a bond H a bond NH O a bond Q3a OH 5471 CMe NH Q1j abond H a bond NH O a bond Q3b OH 5472 CMe NH Q1j a bond H a bond NH O abond Q3c OH

69) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X areany of the following combinations in Table 2, tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.The symbols in Table 2 denote the flowing substituents.

TABLE 2 No A B R¹ L¹ R² L² L³ Y L⁴ R³ X 1 N NMe Q1o a bond Me a bond NHS NH Q3a OH 2 N NMe Q1o a bond Me a bond NH S NH Q3b OH 3 N NMe Q1o abond Me a bond NH S NH Q3c OH 4 N NMe Q1o a bond Me a bond NH S a bondQ3a OH 5 N NMe Q1o a bond Me a bond NH S a bond Q3b OH 6 N NMe Q1o abond Me a bond NH S a bond Q3c OH 7 N NMe Q1o a bond Me a bond NH O NHQ3a OH 8 N NMe Q1o a bond Me a bond NH O NH Q3b OH 9 N NMe Q1o a bond Mea bond NH O NH Q3c OH 10 N NMe Q1o a bond Me a bond NH O a bond Q3a OH11 N NMe Q1o a bond Me a bond NH O a bond Q3b OH 12 N NMe Q1o a bond Mea bond NH O a bond Q3c OH 13 N NMe Q1o a bond H a bond NH S NH Q3a OH 14N NMe Q1o a bond H a bond NH S NH Q3b OH 15 N NMe Q1o a bond H a bond NHS NH Q3c OH 16 N NMe Q1o a bond H a bond NH S a bond Q3a OH 17 N NMe Q1oa bond H a bond NH S a bond Q3b OH 18 N NMe Q1o a bond H a bond NH S abond Q3c OH 19 N NMe Q1o a bond H a bond NH O NH Q3a OH 20 N NMe Q1o abond H a bond NH O NH Q3b OH 21 N NMe Q1o a bond H a bond NH O NH Q3c OH22 N NMe Q1o a bond H a bond NH O a bond Q3a OH 23 N NMe Q1o a bond H abond NH O a bond Q3b OH 24 N NMe Q1o a bond H a bond NH O a bond Q3c OH25 N NMe Q1p a bond Me a bond NH S NH Q3a OH 26 N NMe Q1p a bond Me abond NH S NH Q3b OH 27 N NMe Q1p a bond Me a bond NH S NH Q3c OH 28 NNMe Q1p a bond Me a bond NH S a bond Q3a OH 29 N NMe Q1p a bond Me abond NH S a bond Q3b OH 30 N NMe Q1p a bond Me a bond NH S a bond Q3c OH31 N NMe Q1p a bond Me a bond NH O NH Q3a OH 32 N NMe Q1p a bond Me abond NH O NH Q3b OH 33 N NMe Q1p a bond Me a bond NH O NH Q3c OH 34 NNMe Q1p a bond Me a bond NH O a bond Q3a OH 35 N NMe Q1p a bond Me abond NH O a bond Q3b OH 36 N NMe Q1p a bond Me a bond NH O a bond Q3c OH37 N NMe Q1p a bond H a bond NH S NH Q3a OH 38 N NMe Q1p a bond H a bondNH S NH Q3b OH 39 N NMe Q1p a bond H a bond NH S NH Q3c OH 40 N NMe Q1pa bond H a bond NH S a bond Q3a OH 41 N NMe Q1p a bond H a bond NH S abond Q3b OH 42 N NMe Q1p a bond H a bond NH S a bond Q3c OH 43 N NMe Q1pa bond H a bond NH O NH Q3a OH 44 N NMe Q1p a bond H a bond NH O NH Q3bOH 45 N NMe Q1p a bond H a bond NH O NH Q3c OH 46 N NMe Q1p a bond H abond NH O a bond Q3a OH 47 N NMe Q1p a bond H a bond NH O a bond Q3b OH48 N NMe Q1p a bond H a bond NH O a bond Q3c OH 49 N NMe Q1q a bond Me abond NH S NH Q3a OH 50 N NMe Q1q a bond Me a bond NH S NH Q3b OH 51 NNMe Q1q a bond Me a bond NH S NH Q3c OH 52 N NMe Q1q a bond Me a bond NHS a bond Q3a OH 53 N NMe Q1q a bond Me a bond NH S a bond Q3b OH 54 NNMe Q1q a bond Me a bond NH S a bond Q3c OH 55 N NMe Q1q a bond Me abond NH O NH Q3a OH 56 N NMe Q1q a bond Me a bond NH O NH Q3b OH 57 NNMe Q1q a bond Me a bond NH O NH Q3c OH 58 N NMe Q1q a bond Me a bond NHO a bond Q3a OH 59 N NMe Q1q a bond Me a bond NH O a bond Q3b OH 60 NNMe Q1q a bond Me a bond NH O a bond Q3c OH 61 N NMe Q1q a bond H a bondNH S NH Q3a OH 62 N NMe Q1q a bond H a bond NH S NH Q3b OH 63 N NMe Q1qa bond H a bond NH S NH Q3c OH 64 N NMe Q1q a bond H a bond NH S a bondQ3a OH 65 N NMe Q1q a bond H a bond NH S a bond Q3b OH 66 N NMe Q1q abond H a bond NH S a bond Q3c OH 67 N NMe Q1q a bond H a bond NH O NHQ3a OH 68 N NMe Q1q a bond H a bond NH O NH Q3b OH 69 N NMe Q1q a bond Ha bond NH O NH Q3c OH 70 N NMe Q1q a bond H a bond NH O a bond Q3a OH 71N NMe Q1q a bond H a bond NH O a bond Q3b OH 72 N NMe Q1q a bond H abond NH O a bond Q3c OH 73 N NMe Q1r a bond Me a bond NH S NH Q3a OH 74N NMe Q1r a bond Me a bond NH S NH Q3b OH 75 N NMe Q1r a bond Me a bondNH S NH Q3c OH 76 N NMe Q1r a bond Me a bond NH S a bond Q3a OH 77 N NMeQ1r a bond Me a bond NH S a bond Q3b OH 78 N NMe Q1r a bond Me a bond NHS a bond Q3c OH 79 N NMe Q1r a bond Me a bond NH O NH Q3a OH 80 N NMeQ1r a bond Me a bond NH O NH Q3b OH 81 N NMe Q1r a bond Me a bond NH ONH Q3c OH 82 N NMe Q1r a bond Me a bond NH O a bond Q3a OH 83 N NMe Q1ra bond Me a bond NH O a bond Q3b OH 84 N NMe Q1r a bond Me a bond NH O abond Q3c OH 85 N NMe Q1r a bond H a bond NH S NH Q3a OH 86 N NMe Q1r abond H a bond NH S NH Q3b OH 87 N NMe Q1r a bond H a bond NH S NH Q3c OH88 N NMe Q1r a bond H a bond NH S a bond Q3a OH 89 N NMe Q1r a bond H abond NH S a bond Q3b OH 90 N NMe Q1r a bond H a bond NH S a bond Q3c OH91 N NMe Q1r a bond H a bond NH O NH Q3a OH 92 N NMe Q1r a bond H a bondNH O NH Q3b OH 93 N NMe Q1r a bond H a bond NH O NH Q3c OH 94 N NMe Q1ra bond H a bond NH O a bond Q3a OH 95 N NMe Q1r a bond H a bond NH O abond Q3b OH 96 N NMe Q1r a bond H a bond NH O a bond Q3c OH 97 N NMe Q1sa bond Me a bond NH S NH Q3a OH 98 N NMe Q1s a bond Me a bond NH S NHQ3b OH 99 N NMe Q1s a bond Me a bond NH S NH Q3c OH 100 N NMe Q1s a bondMe a bond NH S a bond Q3a OH 101 N NMe Q1s a bond Me a bond NH S a bondQ3b OH 102 N NMe Q1s a bond Me a bond NH S a bond Q3c OH 103 N NMe Q1s abond Me a bond NH O NH Q3a OH 104 N NMe Q1s a bond Me a bond NH O NH Q3bOH 105 N NMe Q1s a bond Me a bond NH O NH Q3c OH 106 N NMe Q1s a bond Mea bond NH O a bond Q3a OH 107 N NMe Q1s a bond Me a bond NH O a bond Q3bOH 108 N NMe Q1s a bond Me a bond NH O a bond Q3c OH 109 N NMe Q1s abond H a bond NH S NH Q3a OH 110 N NMe Q1s a bond H a bond NH S NH Q3bOH 111 N NMe Q1s a bond H a bond NH S NH Q3c OH 112 N NMe Q1s a bond H abond NH S a bond Q3a OH 113 N NMe Q1s a bond H a bond NH S a bond Q3b OH114 N NMe Q1s a bond H a bond NH S a bond Q3c OH 115 N NMe Q1s a bond Ha bond NH O NH Q3a OH 116 N NMe Q1s a bond H a bond NH O NH Q3b OH 117 NNMe Q1s a bond H a bond NH O NH Q3c OH 118 N NMe Q1s a bond H a bond NHO a bond Q3a OH 119 N NMe Q1s a bond H a bond NH O a bond Q3b OH 120 NNMe Q1s a bond H a bond NH O a bond Q3c OH 121 N NMe Q1t a bond Me abond NH S NH Q3a OH 122 N NMe Q1t a bond Me a bond NH S NH Q3b OH 123 NNMe Q1t a bond Me a bond NH S NH Q3c OH 124 N NMe Q1t a bond Me a bondNH S a bond Q3a OH 125 N NMe Q1t a bond Me a bond NH S a bond Q3b OH 126N NMe Q1t a bond Me a bond NH S a bond Q3c OH 127 N NMe Q1t a bond Me abond NH O NH Q3a OH 128 N NMe Q1t a bond Me a bond NH O NH Q3b OH 129 NNMe Q1t a bond Me a bond NH O NH Q3c OH 130 N NMe Q1t a bond Me a bondNH O a bond Q3a OH 131 N NMe Q1t a bond Me a bond NH O a bond Q3b OH 132N NMe Q1t a bond Me a bond NH O a bond Q3c OH 133 N NMe Q1t a bond H abond NH S NH Q3a OH 134 N NMe Q1t a bond H a bond NH S NH Q3b OH 135 NNMe Q1t a bond H a bond NH S NH Q3c OH 136 N NMe Q1t a bond H a bond NHS a bond Q3a OH 137 N NMe Q1t a bond H a bond NH S a bond Q3b OH 138 NNMe Q1t a bond H a bond NH S a bond Q3c OH 139 N NMe Q1t a bond H a bondNH O NH Q3a OH 140 N NMe Q1t a bond H a bond NH O NH Q3b OH 141 N NMeQ1t a bond H a bond NH O NH Q3c OH 142 N NMe Q1t a bond H a bond NH O abond Q3a OH 143 N NMe Q1t a bond H a bond NH O a bond Q3b OH 144 N NMeQ1t a bond H a bond NH O a bond Q3c OH 145 N NMe Q1u a bond Me a bond NHS NH Q3a OH 146 N NMe Q1u a bond Me a bond NH S NH Q3b OH 147 N NMe Q1ua bond Me a bond NH S NH Q3c OH 148 N NMe Q1u a bond Me a bond NH S abond Q3a OH 149 N NMe Q1u a bond Me a bond NH S a bond Q3b OH 150 N NMeQ1u a bond Me a bond NH S a bond Q3c OH 151 N NMe Q1u a bond Me a bondNH O NH Q3a OH 152 N NMe Q1u a bond Me a bond NH O NH Q3b OH 153 N NMeQ1u a bond Me a bond NH O NH Q3c OH 154 N NMe Q1u a bond Me a bond NH Oa bond Q3a OH 155 N NMe Q1u a bond Me a bond NH O a bond Q3b OH 156 NNMe Q1u a bond Me a bond NH O a bond Q3c OH 157 N NMe Q1u a bond H abond NH S NH Q3a OH 158 N NMe Q1u a bond H a bond NH S NH Q3b OH 159 NNMe Q1u a bond H a bond NH S NH Q3c OH 160 N NMe Q1u a bond H a bond NHS a bond Q3a OH 161 N NMe Q1u a bond H a bond NH S a bond Q3b OH 162 NNMe Q1u a bond H a bond NH S a bond Q3c OH 163 N NMe Q1u a bond H a bondNH O NH Q3a OH 164 N NMe Q1u a bond H a bond NH O NH Q3b OH 165 N NMeQ1u a bond H a bond NH O NH Q3c OH 166 N NMe Q1u a bond H a bond NH O abond Q3a OH 167 N NMe Q1u a bond H a bond NH O a bond Q3b OH 168 N NMeQ1u a bond H a bond NH O a bond Q3c OH 169 N NMe Q1v a bond Me a bond NHS NH Q3a OH 170 N NMe Q1v a bond Me a bond NH S NH Q3b OH 171 N NMe Q1va bond Me a bond NH S NH Q3c OH 172 N NMe Q1v a bond Me a bond NH S abond Q3a OH 173 N NMe Q1v a bond Me a bond NH S a bond Q3b OH 174 N NMeQ1v a bond Me a bond NH S a bond Q3c OH 175 N NMe Q1v a bond Me a bondNH O NH Q3a OH 176 N NMe Q1v a bond Me a bond NH O NH Q3b OH 177 N NMeQ1v a bond Me a bond NH O NH Q3c OH 178 N NMe Q1v a bond Me a bond NH Oa bond Q3a OH 179 N NMe Q1v a bond Me a bond NH O a bond Q3b OH 180 NNMe Q1v a bond Me a bond NH O a bond Q3c OH 181 N NMe Q1v a bond H abond NH S NH Q3a OH 182 N NMe Q1v a bond H a bond NH S NH Q3b OH 183 NNMe Q1v a bond H a bond NH S NH Q3c OH 184 N NMe Q1v a bond H a bond NHS a bond Q3a OH 185 N NMe Q1v a bond H a bond NH S a bond Q3b OH 186 NNMe Q1v a bond H a bond NH S a bond Q3c OH 187 N NMe Q1v a bond H a bondNH O NH Q3a OH 188 N NMe Q1v a bond H a bond NH O NH Q3b OH 189 N NMeQ1v a bond H a bond NH O NH Q3c OH 190 N NMe Q1v a bond H a bond NH O abond Q3a OH 191 N NMe Q1v a bond H a bond NH O a bond Q3b OH 192 N NMeQ1v a bond H a bond NH O a bond Q3c OH 193 N NMe Q1w a bond Me a bond NHS NH Q3a OH 194 N NMe Q1w a bond Me a bond NH S NH Q3b OH 195 N NMe Q1wa bond Me a bond NH S NH Q3c OH 196 N NMe Q1w a bond Me a bond NH S abond Q3a OH 197 N NMe Q1w a bond Me a bond NH S a bond Q3b OH 198 N NMeQ1w a bond Me a bond NH S a bond Q3c OH 199 N NMe Q1w a bond Me a bondNH O NH Q3a OH 200 N NMe Q1w a bond Me a bond NH O NH Q3b OH 201 N NMeQ1w a bond Me a bond NH O NH Q3c OH 202 N NMe Q1w a bond Me a bond NH Oa bond Q3a OH 203 N NMe Q1w a bond Me a bond NH O a bond Q3b OH 204 NNMe Q1w a bond Me a bond NH O a bond Q3c OH 205 N NMe Q1w a bond H abond NH S NH Q3a OH 206 N NMe Q1w a bond H a bond NH S NH Q3b OH 207 NNMe Q1w a bond H a bond NH S NH Q3c OH 208 N NMe Q1w a bond H a bond NHS a bond Q3a OH 209 N NMe Q1w a bond H a bond NH S a bond Q3b OH 210 NNMe Q1w a bond H a bond NH S a bond Q3c OH 211 N NMe Q1w a bond H a bondNH O NH Q3a OH 212 N NMe Q1w a bond H a bond NH O NH Q3b OH 213 N NMeQ1w a bond H a bond NH O NH Q3c OH 214 N NMe Q1w a bond H a bond NH O abond Q3a OH 215 N NMe Q1w a bond H a bond NH O a bond Q3b OH 216 N NMeQ1w a bond H a bond NH O a bond Q3c OH 217 N NMe Q1x a bond Me a bond NHS NH Q3a OH 218 N NMe Q1x a bond Me a bond NH S NH Q3b OH 219 N NMe Q1xa bond Me a bond NH S NH Q3c OH 220 N NMe Q1x a bond Me a bond NH S abond Q3a OH 221 N NMe Q1x a bond Me a bond NH S a bond Q3b OH 222 N NMeQ1x a bond Me a bond NH S a bond Q3c OH 223 N NMe Q1x a bond Me a bondNH O NH Q3a OH 224 N NMe Q1x a bond Me a bond NH O NH Q3b OH 225 N NMeQ1x a bond Me a bond NH O NH Q3c OH 226 N NMe Q1x a bond Me a bond NH Oa bond Q3a OH 227 N NMe Q1x a bond Me a bond NH O a bond Q3b OH 228 NNMe Q1x a bond Me a bond NH O a bond Q3c OH 229 N NMe Q1x a bond H abond NH S NH Q3a OH 230 N NMe Q1x a bond H a bond NH S NH Q3b OH 231 NNMe Q1x a bond H a bond NH S NH Q3c OH 232 N NMe Q1x a bond H a bond NHS a bond Q3a OH 233 N NMe Q1x a bond H a bond NH S a bond Q3b OH 234 NNMe Q1x a bond H a bond NH S a bond Q3c OH 235 N NMe Q1x a bond H a bondNH O NH Q3a OH 236 N NMe Q1x a bond H a bond NH O NH Q3b OH 237 N NMeQ1x a bond H a bond NH O NH Q3c OH 238 N NMe Q1x a bond H a bond NH O abond Q3a OH 239 N NMe Q1x a bond H a bond NH O a bond Q3b OH 240 N NMeQ1x a bond H a bond NH O a bond Q3c OH 241 N NEt Q1o a bond Me a bond NHS NH Q3a OH 242 N NEt Q1o a bond Me a bond NH S NH Q3b OH 243 N NEt Q1oa bond Me a bond NH S NH Q3c OH 244 N NEt Q1o a bond Me a bond NH S abond Q3a OH 245 N NEt Q1o a bond Me a bond NH S a bond Q3b OH 246 N NEtQ1o a bond Me a bond NH S a bond Q3c OH 247 N NEt Q1o a bond Me a bondNH O NH Q3a OH 248 N NEt Q1o a bond Me a bond NH O NH Q3b OH 249 N NEtQ1o a bond Me a bond NH O NH Q3c OH 250 N NEt Q1o a bond Me a bond NH Oa bond Q3a OH 251 N NEt Q1o a bond Me a bond NH O a bond Q3b OH 252 NNEt Q1o a bond Me a bond NH O a bond Q3c OH 253 N NEt Q1o a bond H abond NH S NH Q3a OH 254 N NEt Q1o a bond H a bond NH S NH Q3b OH 255 NNEt Q1o a bond H a bond NH S NH Q3c OH 256 N NEt Q1o a bond H a bond NHS a bond Q3a OH 257 N NEt Q1o a bond H a bond NH S a bond Q3b OH 258 NNEt Q1o a bond H a bond NH S a bond Q3c OH 259 N NEt Q1o a bond H a bondNH O NH Q3a OH 260 N NEt Q1o a bond H a bond NH O NH Q3b OH 261 N NEtQ1o a bond H a bond NH O NH Q3c OH 262 N NEt Q1o a bond H a bond NH O abond Q3a OH 263 N NEt Q1o a bond H a bond NH O a bond Q3b OH 264 N NEtQ1o a bond H a bond NH O a bond Q3c OH 265 N NEt Q1p a bond Me a bond NHS NH Q3a OH 266 N NEt Q1p a bond Me a bond NH S NH Q3b OH 267 N NEt Q1pa bond Me a bond NH S NH Q3c OH 268 N NEt Q1p a bond Me a bond NH S abond Q3a OH 269 N NEt Q1p a bond Me a bond NH S a bond Q3b OH 270 N NEtQ1p a bond Me a bond NH S a bond Q3c OH 271 N NEt Q1p a bond Me a bondNH O NH Q3a OH 272 N NEt Q1p a bond Me a bond NH O NH Q3b OH 273 N NEtQ1p a bond Me a bond NH O NH Q3c OH 274 N NEt Q1p a bond Me a bond NH Oa bond Q3a OH 275 N NEt Q1p a bond Me a bond NH O a bond Q3b OH 276 NNEt Q1p a bond Me a bond NH O a bond Q3c OH 277 N NEt Q1p a bond H abond NH S NH Q3a OH 278 N NEt Q1p a bond H a bond NH S NH Q3b OH 279 NNEt Q1p a bond H a bond NH S NH Q3c OH 280 N NEt Q1p a bond H a bond NHS a bond Q3a OH 281 N NEt Q1p a bond H a bond NH S a bond Q3b OH 282 NNEt Q1p a bond H a bond NH S a bond Q3c OH 283 N NEt Q1p a bond H a bondNH O NH Q3a OH 284 N NEt Q1p a bond H a bond NH O NH Q3b OH 285 N NEtQ1p a bond H a bond NH O NH Q3c OH 286 N NEt Q1p a bond H a bond NH O abond Q3a OH 287 N NEt Q1p a bond H a bond NH O a bond Q3b OH 288 N NEtQ1p a bond H a bond NH O a bond Q3c OH 289 N NEt Q1q a bond Me a bond NHS NH Q3a OH 290 N NEt Q1q a bond Me a bond NH S NH Q3b OH 291 N NEt Q1qa bond Me a bond NH S NH Q3c OH 292 N NEt Q1q a bond Me a bond NH S abond Q3a OH 293 N NEt Q1q a bond Me a bond NH S a bond Q3b OH 294 N NEtQ1q a bond Me a bond NH S a bond Q3c OH 295 N NEt Q1q a bond Me a bondNH O NH Q3a OH 296 N NEt Q1q a bond Me a bond NH O NH Q3b OH 297 N NEtQ1q a bond Me a bond NH O NH Q3c OH 298 N NEt Q1q a bond Me a bond NH Oa bond Q3a OH 299 N NEt Q1q a bond Me a bond NH O a bond Q3b OH 300 NNEt Q1q a bond Me a bond NH O a bond Q3c OH 301 N NEt Q1q a bond H abond NH S NH Q3a OH 302 N NEt Q1q a bond H a bond NH S NH Q3b OH 303 NNEt Q1q a bond H a bond NH S NH Q3c OH 304 N NEt Q1q a bond H a bond NHS a bond Q3a OH 305 N NEt Q1q a bond H a bond NH S a bond Q3b OH 306 NNEt Q1q a bond H a bond NH S a bond Q3c OH 307 N NEt Q1q a bond H a bondNH O NH Q3a OH 308 N NEt Q1q a bond H a bond NH O NH Q3b OH 309 N NEtQ1q a bond H a bond NH O NH Q3c OH 310 N NEt Q1q a bond H a bond NH O abond Q3a OH 311 N NEt Q1q a bond H a bond NH O a bond Q3b OH 312 N NEtQ1q a bond H a bond NH O a bond Q3c OH 313 N NEt Q1r a bond Me a bond NHS NH Q3a OH 314 N NEt Q1r a bond Me a bond NH S NH Q3b OH 315 N NEt Q1ra bond Me a bond NH S NH Q3c OH 316 N NEt Q1r a bond Me a bond NH S abond Q3a OH 317 N NEt Q1r a bond Me a bond NH S a bond Q3b OH 318 N NEtQ1r a bond Me a bond NH S a bond Q3c OH 319 N NEt Q1r a bond Me a bondNH O NH Q3a OH 320 N NEt Q1r a bond Me a bond NH O NH Q3b OH 321 N NEtQ1r a bond Me a bond NH O NH Q3c OH 322 N NEt Q1r a bond Me a bond NH Oa bond Q3a OH 323 N NEt Q1r a bond Me a bond NH O a bond Q3b OH 324 NNEt Q1r a bond Me a bond NH O a bond Q3c OH 325 N NEt Q1r a bond H abond NH S NH Q3a OH 326 N NEt Q1r a bond H a bond NH S NH Q3b OH 327 NNEt Q1r a bond H a bond NH S NH Q3c OH 328 N NEt Q1r a bond H a bond NHS a bond Q3a OH 329 N NEt Q1r a bond H a bond NH S a bond Q3b OH 330 NNEt Q1r a bond H a bond NH S a bond Q3c OH 331 N NEt Q1r a bond H a bondNH O NH Q3a OH 332 N NEt Q1r a bond H a bond NH O NH Q3b OH 333 N NEtQ1r a bond H a bond NH O NH Q3c OH 334 N NEt Q1r a bond H a bond NH O abond Q3a OH 335 N NEt Q1r a bond H a bond NH O a bond Q3b OH 336 N NEtQ1r a bond H a bond NH O a bond Q3c OH 337 N NEt Q1s a bond Me a bond NHS NH Q3a OH 338 N NEt Q1s a bond Me a bond NH S NH Q3b OH 339 N NEt Q1sa bond Me a bond NH S NH Q3c OH 340 N NEt Q1s a bond Me a bond NH S abond Q3a OH 341 N NEt Q1s a bond Me a bond NH S a bond Q3b OH 342 N NEtQ1s a bond Me a bond NH S a bond Q3c OH 343 N NEt Q1s a bond Me a bondNH O NH Q3a OH 344 N NEt Q1s a bond Me a bond NH O NH Q3b OH 345 N NEtQ1s a bond Me a bond NH O NH Q3c OH 346 N NEt Q1s a bond Me a bond NH Oa bond Q3a OH 347 N NEt Q1s a bond Me a bond NH O a bond Q3b OH 348 NNEt Q1s a bond Me a bond NH O a bond Q3c OH 349 N NEt Q1s a bond H abond NH S NH Q3a OH 350 N NEt Q1s a bond H a bond NH S NH Q3b OH 351 NNEt Q1s a bond H a bond NH S NH Q3c OH 352 N NEt Q1s a bond H a bond NHS a bond Q3a OH 353 N NEt Q1s a bond H a bond NH S a bond Q3b OH 354 NNEt Q1s a bond H a bond NH S a bond Q3c OH 355 N NEt Q1s a bond H a bondNH O NH Q3a OH 356 N NEt Q1s a bond H a bond NH O NH Q3b OH 357 N NEtQ1s a bond H a bond NH O NH Q3c OH 358 N NEt Q1s a bond H a bond NH O abond Q3a OH 359 N NEt Q1s a bond H a bond NH O a bond Q3b OH 360 N NEtQ1s a bond H a bond NH O a bond Q3c OH 361 N NEt Q1t a bond Me a bond NHS NH Q3a OH 362 N NEt Q1t a bond Me a bond NH S NH Q3b OH 363 N NEt Q1ta bond Me a bond NH S NH Q3c OH 364 N NEt Q1t a bond Me a bond NH S abond Q3a OH 365 N NEt Q1t a bond Me a bond NH S a bond Q3b OH 366 N NEtQ1t a bond Me a bond NH S a bond Q3c OH 367 N NEt Q1t a bond Me a bondNH O NH Q3a OH 368 N NEt Q1t a bond Me a bond NH O NH Q3b OH 369 N NEtQ1t a bond Me a bond NH O NH Q3c OH 370 N NEt Q1t a bond Me a bond NH Oa bond Q3a OH 371 N NEt Q1t a bond Me a bond NH O a bond Q3b OH 372 NNEt Q1t a bond Me a bond NH O a bond Q3c OH 373 N NEt Q1t a bond H abond NH S NH Q3a OH 374 N NEt Q1t a bond H a bond NH S NH Q3b OH 375 NNEt Q1t a bond H a bond NH S NH Q3c OH 376 N NEt Q1t a bond H a bond NHS a bond Q3a OH 377 N NEt Q1t a bond H a bond NH S a bond Q3b OH 378 NNEt Q1t a bond H a bond NH S a bond Q3c OH 379 N NEt Q1t a bond H a bondNH O NH Q3a OH 380 N NEt Q1t a bond H a bond NH O NH Q3b OH 381 N NEtQ1t a bond H a bond NH O NH Q3c OH 382 N NEt Q1t a bond H a bond NH O abond Q3a OH 383 N NEt Q1t a bond H a bond NH O a bond Q3b OH 384 N NEtQ1t a bond H a bond NH O a bond Q3c OH 385 N NEt Q1u a bond Me a bond NHS NH Q3a OH 386 N NEt Q1u a bond Me a bond NH S NH Q3b OH 387 N NEt Q1ua bond Me a bond NH S NH Q3c OH 388 N NEt Q1u a bond Me a bond NH S abond Q3a OH 389 N NEt Q1u a bond Me a bond NH S a bond Q3b OH 390 N NEtQ1u a bond Me a bond NH S a bond Q3c OH 391 N NEt Q1u a bond Me a bondNH O NH Q3a OH 392 N NEt Q1u a bond Me a bond NH O NH Q3b OH 393 N NEtQ1u a bond Me a bond NH O NH Q3c OH 394 N NEt Q1u a bond Me a bond NH Oa bond Q3a OH 395 N NEt Q1u a bond Me a bond NH O a bond Q3b OH 396 NNEt Q1u a bond Me a bond NH O a bond Q3c OH 397 N NEt Q1u a bond H abond NH S NH Q3a OH 398 N NEt Q1u a bond H a bond NH S NH Q3b OH 399 NNEt Q1u a bond H a bond NH S NH Q3c OH 400 N NEt Q1u a bond H a bond NHS a bond Q3a OH 401 N NEt Q1u a bond H a bond NH S a bond Q3b OH 402 NNEt Q1u a bond H a bond NH S a bond Q3c OH 403 N NEt Q1u a bond H a bondNH O NH Q3a OH 404 N NEt Q1u a bond H a bond NH O NH Q3b OH 405 N NEtQ1u a bond H a bond NH O NH Q3c OH 406 N NEt Q1u a bond H a bond NH O abond Q3a OH 407 N NEt Q1u a bond H a bond NH O a bond Q3b OH 408 N NEtQ1u a bond H a bond NH O a bond Q3c OH 409 N NEt Q1v a bond Me a bond NHS NH Q3a OH 410 N NEt Q1v a bond Me a bond NH S NH Q3b OH 411 N NEt Q1va bond Me a bond NH S NH Q3c OH 412 N NEt Q1v a bond Me a bond NH S abond Q3a OH 413 N NEt Q1v a bond Me a bond NH S a bond Q3b OH 414 N NEtQ1v a bond Me a bond NH S a bond Q3c OH 415 N NEt Q1v a bond Me a bondNH O NH Q3a OH 416 N NEt Q1v a bond Me a bond NH O NH Q3b OH 417 N NEtQ1v a bond Me a bond NH O NH Q3c OH 418 N NEt Q1v a bond Me a bond NH Oa bond Q3a OH 419 N NEt Q1v a bond Me a bond NH O a bond Q3b OH 420 NNEt Q1v a bond Me a bond NH O a bond Q3c OH 421 N NEt Q1v a bond H abond NH S NH Q3a OH 422 N NEt Q1v a bond H a bond NH S NH Q3b OH 423 NNEt Q1v a bond H a bond NH S NH Q3c OH 424 N NEt Q1v a bond H a bond NHS a bond Q3a OH 425 N NEt Q1v a bond H a bond NH S a bond Q3b OH 426 NNEt Q1v a bond H a bond NH S a bond Q3c OH 427 N NEt Q1v a bond H a bondNH O NH Q3a OH 428 N NEt Q1v a bond H a bond NH O NH Q3b OH 429 N NEtQ1v a bond H a bond NH O NH Q3c OH 430 N NEt Q1v a bond H a bond NH O abond Q3a OH 431 N NEt Q1v a bond H a bond NH O a bond Q3b OH 432 N NEtQ1v a bond H a bond NH O a bond Q3c OH 433 N NEt Q1w a bond Me a bond NHS NH Q3a OH 434 N NEt Q1w a bond Me a bond NH S NH Q3b OH 435 N NEt Q1wa bond Me a bond NH S NH Q3c OH 436 N NEt Q1w a bond Me a bond NH S abond Q3a OH 437 N NEt Q1w a bond Me a bond NH S a bond Q3b OH 438 N NEtQ1w a bond Me a bond NH S a bond Q3c OH 439 N NEt Q1w a bond Me a bondNH O NH Q3a OH 440 N NEt Q1w a bond Me a bond NH O NH Q3b OH 441 N NEtQ1w a bond Me a bond NH O NH Q3c OH 442 N NEt Q1w a bond Me a bond NH Oa bond Q3a OH 443 N NEt Q1w a bond Me a bond NH O a bond Q3b OH 444 NNEt Q1w a bond Me a bond NH O a bond Q3c OH 445 N NEt Q1w a bond H abond NH S NH Q3a OH 446 N NEt Q1w a bond H a bond NH S NH Q3b OH 447 NNEt Q1w a bond H a bond NH S NH Q3c OH 448 N NEt Q1w a bond H a bond NHS a bond Q3a OH 449 N NEt Q1w a bond H a bond NH S a bond Q3b OH 450 NNEt Q1w a bond H a bond NH S a bond Q3c OH 451 N NEt Q1w a bond H a bondNH O NH Q3a OH 452 N NEt Q1w a bond H a bond NH O NH Q3b OH 453 N NEtQ1w a bond H a bond NH O NH Q3c OH 454 N NEt Q1w a bond H a bond NH O abond Q3a OH 455 N NEt Q1w a bond H a bond NH O a bond Q3b OH 456 N NEtQ1w a bond H a bond NH O a bond Q3c OH 457 N NEt Q1x a bond Me a bond NHS NH Q3a OH 458 N NEt Q1x a bond Me a bond NH S NH Q3b OH 459 N NEt Q1xa bond Me a bond NH S NH Q3c OH 460 N NEt Q1x a bond Me a bond NH S abond Q3a OH 461 N NEt Q1x a bond Me a bond NH S a bond Q3b OH 462 N NEtQ1x a bond Me a bond NH S a bond Q3c OH 463 N NEt Q1x a bond Me a bondNH O NH Q3a OH 464 N NEt Q1x a bond Me a bond NH O NH Q3b OH 465 N NEtQ1x a bond Me a bond NH O NH Q3c OH 466 N NEt Q1x a bond Me a bond NH Oa bond Q3a OH 467 N NEt Q1x a bond Me a bond NH O a bond Q3b OH 468 NNEt Q1x a bond Me a bond NH O a bond Q3c OH 469 N NEt Q1x a bond H abond NH S NH Q3a OH 470 N NEt Q1x a bond H a bond NH S NH Q3b OH 471 NNEt Q1x a bond H a bond NH S NH Q3c OH 472 N NEt Q1x a bond H a bond NHS a bond Q3a OH 473 N NEt Q1x a bond H a bond NH S a bond Q3b OH 474 NNEt Q1x a bond H a bond NH S a bond Q3c OH 475 N NEt Q1x a bond H a bondNH O NH Q3a OH 476 N NEt Q1x a bond H a bond NH O NH Q3b OH 477 N NEtQ1x a bond H a bond NH O NH Q3c OH 478 N NEt Q1x a bond H a bond NH O abond Q3a OH 479 N NEt Q1x a bond H a bond NH O a bond Q3b OH 480 N NEtQ1x a bond H a bond NH O a bond Q3c OH 481 N S Q1o a bond Me a bond NH SNH Q3a OH 482 N S Q1o a bond Me a bond NH S NH Q3b OH 483 N S Q1o a bondMe a bond NH S NH Q3c OH 484 N S Q1o a bond Me a bond NH S a bond Q3a OH485 N S Q1o a bond Me a bond NH S a bond Q3b OH 486 N S Q1o a bond Me abond NH S a bond Q3c OH 487 N S Q1o a bond Me a bond NH O NH Q3a OH 488N S Q1o a bond Me a bond NH O NH Q3b OH 489 N S Q1o a bond Me a bond NHO NH Q3c OH 490 N S Q1o a bond Me a bond NH O a bond Q3a OH 491 N S Q1oa bond Me a bond NH O a bond Q3b OH 492 N S Q1o a bond Me a bond NH O abond Q3c OH 493 N S Q1o a bond H a bond NH S NH Q3a OH 494 N S Q1o abond H a bond NH S NH Q3b OH 495 N S Q1o a bond H a bond NH S NH Q3c OH496 N S Q1o a bond H a bond NH S a bond Q3a OH 497 N S Q1o a bond H abond NH S a bond Q3b OH 498 N S Q1o a bond H a bond NH S a bond Q3c OH499 N S Q1o a bond H a bond NH O NH Q3a OH 500 N S Q1o a bond H a bondNH O NH Q3b OH 501 N S Q1o a bond H a bond NH O NH Q3c OH 502 N S Q1o abond H a bond NH O a bond Q3a OH 503 N S Q1o a bond H a bond NH O a bondQ3b OH 504 N S Q1o a bond H a bond NH O a bond Q3c OH 505 N S Q1p a bondMe a bond NH S NH Q3a OH 506 N S Q1p a bond Me a bond NH S NH Q3b OH 507N S Q1p a bond Me a bond NH S NH Q3c OH 508 N S Q1p a bond Me a bond NHS a bond Q3a OH 509 N S Q1p a bond Me a bond NH S a bond Q3b OH 510 N SQ1p a bond Me a bond NH S a bond Q3c OH 511 N S Q1p a bond Me a bond NHO NH Q3a OH 512 N S Q1p a bond Me a bond NH O NH Q3b OH 513 N S Q1p abond Me a bond NH O NH Q3c OH 514 N S Q1p a bond Me a bond NH O a bondQ3a OH 515 N S Q1p a bond Me a bond NH O a bond Q3b OH 516 N S Q1p abond Me a bond NH O a bond Q3c OH 517 N S Q1p a bond H a bond NH S NHQ3a OH 518 N S Q1p a bond H a bond NH S NH Q3b OH 519 N S Q1p a bond H abond NH S NH Q3c OH 520 N S Q1p a bond H a bond NH S a bond Q3a OH 521 NS Q1p a bond H a bond NH S a bond Q3b OH 522 N S Q1p a bond H a bond NHS a bond Q3c OH 523 N S Q1p a bond H a bond NH O NH Q3a OH 524 N S Q1p abond H a bond NH O NH Q3b OH 525 N S Q1p a bond H a bond NH O NH Q3c OH526 N S Q1p a bond H a bond NH O a bond Q3a OH 527 N S Q1p a bond H abond NH O a bond Q3b OH 528 N S Q1p a bond H a bond NH O a bond Q3c OH529 N S Q1q a bond Me a bond NH S NH Q3a OH 530 N S Q1q a bond Me a bondNH S NH Q3b OH 531 N S Q1q a bond Me a bond NH S NH Q3c OH 532 N S Q1q abond Me a bond NH S a bond Q3a OH 533 N S Q1q a bond Me a bond NH S abond Q3b OH 534 N S Q1q a bond Me a bond NH S a bond Q3c OH 535 N S Q1qa bond Me a bond NH O NH Q3a OH 536 N S Q1q a bond Me a bond NH O NH Q3bOH 537 N S Q1q a bond Me a bond NH O NH Q3c OH 538 N S Q1q a bond Me abond NH O a bond Q3a OH 539 N S Q1q a bond Me a bond NH O a bond Q3b OH540 N S Q1q a bond Me a bond NH O a bond Q3c OH 541 N S Q1q a bond H abond NH S NH Q3a OH 542 N S Q1q a bond H a bond NH S NH Q3b OH 543 N SQ1q a bond H a bond NH S NH Q3c OH 544 N S Q1q a bond H a bond NH S abond Q3a OH 545 N S Q1q a bond H a bond NH S a bond Q3b OH 546 N S Q1q abond H a bond NH S a bond Q3c OH 547 N S Q1q a bond H a bond NH O NH Q3aOH 548 N S Q1q a bond H a bond NH O NH Q3b OH 549 N S Q1q a bond H abond NH O NH Q3c OH 550 N S Q1q a bond H a bond NH O a bond Q3a OH 551 NS Q1q a bond H a bond NH O a bond Q3b OH 552 N S Q1q a bond H a bond NHO a bond Q3c OH 553 N S Q1r a bond Me a bond NH S NH Q3a OH 554 N S Q1ra bond Me a bond NH S NH Q3b OH 555 N S Q1r a bond Me a bond NH S NH Q3cOH 556 N S Q1r a bond Me a bond NH S a bond Q3a OH 557 N S Q1r a bond Mea bond NH S a bond Q3b OH 558 N S Q1r a bond Me a bond NH S a bond Q3cOH 559 N S Q1r a bond Me a bond NH O NH Q3a OH 560 N S Q1r a bond Me abond NH O NH Q3b OH 561 N S Q1r a bond Me a bond NH O NH Q3c OH 562 N SQ1r a bond Me a bond NH O a bond Q3a OH 563 N S Q1r a bond Me a bond NHO a bond Q3b OH 564 N S Q1r a bond Me a bond NH O a bond Q3c OH 565 N SQ1r a bond H a bond NH S NH Q3a OH 566 N S Q1r a bond H a bond NH S NHQ3b OH 567 N S Q1r a bond H a bond NH S NH Q3c OH 568 N S Q1r a bond H abond NH S a bond Q3a OH 569 N S Q1r a bond H a bond NH S a bond Q3b OH570 N S Q1r a bond H a bond NH S a bond Q3c OH 571 N S Q1r a bond H abond NH O NH Q3a OH 572 N S Q1r a bond H a bond NH O NH Q3b OH 573 N SQ1r a bond H a bond NH O NH Q3c OH 574 N S Q1r a bond H a bond NH O abond Q3a OH 575 N S Q1r a bond H a bond NH O a bond Q3b OH 576 N S Q1r abond H a bond NH O a bond Q3c OH 577 N S Q1s a bond Me a bond NH S NHQ3a OH 578 N S Q1s a bond Me a bond NH S NH Q3b OH 579 N S Q1s a bond Mea bond NH S NH Q3c OH 580 N S Q1s a bond Me a bond NH S a bond Q3a OH581 N S Q1s a bond Me a bond NH S a bond Q3b OH 582 N S Q1s a bond Me abond NH S a bond Q3c OH 583 N S Q1s a bond Me a bond NH O NH Q3a OH 584N S Q1s a bond Me a bond NH O NH Q3b OH 585 N S Q1s a bond Me a bond NHO NH Q3c OH 586 N S Q1s a bond Me a bond NH O a bond Q3a OH 587 N S Q1sa bond Me a bond NH O a bond Q3b OH 588 N S Q1s a bond Me a bond NH O abond Q3c OH 589 N S Q1s a bond H a bond NH S NH Q3a OH 590 N S Q1s abond H a bond NH S NH Q3b OH 591 N S Q1s a bond H a bond NH S NH Q3c OH592 N S Q1s a bond H a bond NH S a bond Q3a OH 593 N S Q1s a bond H abond NH S a bond Q3b OH 594 N S Q1s a bond H a bond NH S a bond Q3c OH595 N S Q1s a bond H a bond NH O NH Q3a OH 596 N S Q1s a bond H a bondNH O NH Q3b OH 597 N S Q1s a bond H a bond NH O NH Q3c OH 598 N S Q1s abond H a bond NH O a bond Q3a OH 599 N S Q1s a bond H a bond NH O a bondQ3b OH 600 N S Q1s a bond H a bond NH O a bond Q3c OH 601 N S Q1t a bondMe a bond NH S NH Q3a OH 602 N S Q1t a bond Me a bond NH S NH Q3b OH 603N S Q1t a bond Me a bond NH S NH Q3c OH 604 N S Q1t a bond Me a bond NHS a bond Q3a OH 605 N S Q1t a bond Me a bond NH S a bond Q3b OH 606 N SQ1t a bond Me a bond NH S a bond Q3c OH 607 N S Q1t a bond Me a bond NHO NH Q3a OH 608 N S Q1t a bond Me a bond NH O NH Q3b OH 609 N S Q1t abond Me a bond NH O NH Q3c OH 610 N S Q1t a bond Me a bond NH O a bondQ3a OH 611 N S Q1t a bond Me a bond NH O a bond Q3b OH 612 N S Q1t abond Me a bond NH O a bond Q3c OH 613 N S Q1t a bond H a bond NH S NHQ3a OH 614 N S Q1t a bond H a bond NH S NH Q3b OH 615 N S Q1t a bond H abond NH S NH Q3c OH 616 N S Q1t a bond H a bond NH S a bond Q3a OH 617 NS Q1t a bond H a bond NH S a bond Q3b OH 618 N S Q1t a bond H a bond NHS a bond Q3c OH 619 N S Q1t a bond H a bond NH O NH Q3a OH 620 N S Q1t abond H a bond NH O NH Q3b OH 621 N S Q1t a bond H a bond NH O NH Q3c OH622 N S Q1t a bond H a bond NH O a bond Q3a OH 623 N S Q1t a bond H abond NH O a bond Q3b OH 624 N S Q1t a bond H a bond NH O a bond Q3c OH625 N S Q1u a bond Me a bond NH S NH Q3a OH 626 N S Q1u a bond Me a bondNH S NH Q3b OH 627 N S Q1u a bond Me a bond NH S NH Q3c OH 628 N S Q1u abond Me a bond NH S a bond Q3a OH 629 N S Q1u a bond Me a bond NH S abond Q3b OH 630 N S Q1u a bond Me a bond NH S a bond Q3c OH 631 N S Q1ua bond Me a bond NH O NH Q3a OH 632 N S Q1u a bond Me a bond NH O NH Q3bOH 633 N S Q1u a bond Me a bond NH O NH Q3c OH 634 N S Q1u a bond Me abond NH O a bond Q3a OH 635 N S Q1u a bond Me a bond NH O a bond Q3b OH636 N S Q1u a bond Me a bond NH O a bond Q3c OH 637 N S Q1u a bond H abond NH S NH Q3a OH 638 N S Q1u a bond H a bond NH S NH Q3b OH 639 N SQ1u a bond H a bond NH S NH Q3c OH 640 N S Q1u a bond H a bond NH S abond Q3a OH 641 N S Q1u a bond H a bond NH S a bond Q3b OH 642 N S Q1u abond H a bond NH S a bond Q3c OH 643 N S Q1u a bond H a bond NH O NH Q3aOH 644 N S Q1u a bond H a bond NH O NH Q3b OH 645 N S Q1u a bond H abond NH O NH Q3c OH 646 N S Q1u a bond H a bond NH O a bond Q3a OH 647 NS Q1u a bond H a bond NH O a bond Q3b OH 648 N S Q1u a bond H a bond NHO a bond Q3c OH 649 N S Q1v a bond Me a bond NH S NH Q3a OH 650 N S Q1va bond Me a bond NH S NH Q3b OH 651 N S Q1v a bond Me a bond NH S NH Q3cOH 652 N S Q1v a bond Me a bond NH S a bond Q3a OH 653 N S Q1v a bond Mea bond NH S a bond Q3b OH 654 N S Q1v a bond Me a bond NH S a bond Q3cOH 655 N S Q1v a bond Me a bond NH O NH Q3a OH 656 N S Q1v a bond Me abond NH O NH Q3b OH 657 N S Q1v a bond Me a bond NH O NH Q3c OH 658 N SQ1v a bond Me a bond NH O a bond Q3a OH 659 N S Q1v a bond Me a bond NHO a bond Q3b OH 660 N S Q1v a bond Me a bond NH O a bond Q3c OH 661 N SQ1v a bond H a bond NH S NH Q3a OH 662 N S Q1v a bond H a bond NH S NHQ3b OH 663 N S Q1v a bond H a bond NH S NH Q3c OH 664 N S Q1v a bond H abond NH S a bond Q3a OH 665 N S Q1v a bond H a bond NH S a bond Q3b OH666 N S Q1v a bond H a bond NH S a bond Q3c OH 667 N S Q1v a bond H abond NH O NH Q3a OH 668 N S Q1v a bond H a bond NH O NH Q3b OH 669 N SQ1v a bond H a bond NH O NH Q3c OH 670 N S Q1v a bond H a bond NH O abond Q3a OH 671 N S Q1v a bond H a bond NH O a bond Q3b OH 672 N S Q1v abond H a bond NH O a bond Q3c OH 673 N S Q1w a bond Me a bond NH S NHQ3a OH 674 N S Q1w a bond Me a bond NH S NH Q3b OH 675 N S Q1w a bond Mea bond NH S NH Q3c OH 676 N S Q1w a bond Me a bond NH S a bond Q3a OH677 N S Q1w a bond Me a bond NH S a bond Q3b OH 678 N S Q1w a bond Me abond NH S a bond Q3c OH 679 N S Q1w a bond Me a bond NH O NH Q3a OH 680N S Q1w a bond Me a bond NH O NH Q3b OH 681 N S Q1w a bond Me a bond NHO NH Q3c OH 682 N S Q1w a bond Me a bond NH O a bond Q3a OH 683 N S Q1wa bond Me a bond NH O a bond Q3b OH 684 N S Q1w a bond Me a bond NH O abond Q3c OH 685 N S Q1w a bond H a bond NH S NH Q3a OH 686 N S Q1w abond H a bond NH S NH Q3b OH 687 N S Q1w a bond H a bond NH S NH Q3c OH688 N S Q1w a bond H a bond NH S a bond Q3a OH 689 N S Q1w a bond H abond NH S a bond Q3b OH 690 N S Q1w a bond H a bond NH S a bond Q3c OH691 N S Q1w a bond H a bond NH O NH Q3a OH 692 N S Q1w a bond H a bondNH O NH Q3b OH 693 N S Q1w a bond H a bond NH O NH Q3c OH 694 N S Q1w abond H a bond NH O a bond Q3a OH 695 N S Q1w a bond H a bond NH O a bondQ3b OH 696 N S Q1w a bond H a bond NH O a bond Q3c OH 697 N S Q1x a bondMe a bond NH S NH Q3a OH 698 N S Q1x a bond Me a bond NH S NH Q3b OH 699N S Q1x a bond Me a bond NH S NH Q3c OH 700 N S Q1x a bond Me a bond NHS a bond Q3a OH 701 N S Q1x a bond Me a bond NH S a bond Q3b OH 702 N SQ1x a bond Me a bond NH S a bond Q3c OH 703 N S Q1x a bond Me a bond NHO NH Q3a OH 704 N S Q1x a bond Me a bond NH O NH Q3b OH 705 N S Q1x abond Me a bond NH O NH Q3c OH 706 N S Q1x a bond Me a bond NH O a bondQ3a OH 707 N S Q1x a bond Me a bond NH O a bond Q3b OH 708 N S Q1x abond Me a bond NH O a bond Q3c OH 709 N S Q1x a bond H a bond NH S NHQ3a OH 710 N S Q1x a bond H a bond NH S NH Q3b OH 711 N S Q1x a bond H abond NH S NH Q3c OH 712 N S Q1x a bond H a bond NH S a bond Q3a OH 713 NS Q1x a bond H a bond NH S a bond Q3b OH 714 N S Q1x a bond H a bond NHS a bond Q3c OH 715 N S Q1x a bond H a bond NH O NH Q3a OH 716 N S Q1x abond H a bond NH O NH Q3b OH 717 N S Q1x a bond H a bond NH O NH Q3c OH718 N S Q1x a bond H a bond NH O a bond Q3a OH 719 N S Q1x a bond H abond NH O a bond Q3b OH 720 N S Q1x a bond H a bond NH O a bond Q3c OH721 N O Q1o a bond Me a bond NH S NH Q3a OH 722 N O Q1o a bond Me a bondNH S NH Q3b OH 723 N O Q1o a bond Me a bond NH S NH Q3c OH 724 N O Q1o abond Me a bond NH S a bond Q3a OH 725 N O Q1o a bond Me a bond NH S abond Q3b OH 726 N O Q1o a bond Me a bond NH S a bond Q3c OH 727 N O Q1oa bond Me a bond NH O NH Q3a OH 728 N O Q1o a bond Me a bond NH O NH Q3bOH 729 N O Q1o a bond Me a bond NH O NH Q3c OH 730 N O Q1o a bond Me abond NH O a bond Q3a OH 731 N O Q1o a bond Me a bond NH O a bond Q3b OH732 N O Q1o a bond Me a bond NH O a bond Q3c OH 733 N O Q1o a bond H abond NH S NH Q3a OH 734 N O Q1o a bond H a bond NH S NH Q3b OH 735 N OQ1o a bond H a bond NH S NH Q3c OH 736 N O Q1o a bond H a bond NH S abond Q3a OH 737 N O Q1o a bond H a bond NH S a bond Q3b OH 738 N O Q1o abond H a bond NH S a bond Q3c OH 739 N O Q1o a bond H a bond NH O NH Q3aOH 740 N O Q1o a bond H a bond NH O NH Q3b OH 741 N O Q1o a bond H abond NH O NH Q3c OH 742 N O Q1o a bond H a bond NH O a bond Q3a OH 743 NO Q1o a bond H a bond NH O a bond Q3b OH 744 N O Q1o a bond H a bond NHO a bond Q3c OH 745 N O Q1p a bond Me a bond NH S NH Q3a OH 746 N O Q1pa bond Me a bond NH S NH Q3b OH 747 N O Q1p a bond Me a bond NH S NH Q3cOH 748 N O Q1p a bond Me a bond NH S a bond Q3a OH 749 N O Q1p a bond Mea bond NH S a bond Q3b OH 750 N O Q1p a bond Me a bond NH S a bond Q3cOH 751 N O Q1p a bond Me a bond NH O NH Q3a OH 752 N O Q1p a bond Me abond NH O NH Q3b OH 753 N O Q1p a bond Me a bond NH O NH Q3c OH 754 N OQ1p a bond Me a bond NH O a bond Q3a OH 755 N O Q1p a bond Me a bond NHO a bond Q3b OH 756 N O Q1p a bond Me a bond NH O a bond Q3c OH 757 N OQ1p a bond H a bond NH S NH Q3a OH 758 N O Q1p a bond H a bond NH S NHQ3b OH 759 N O Q1p a bond H a bond NH S NH Q3c OH 760 N O Q1p a bond H abond NH S a bond Q3a OH 761 N O Q1p a bond H a bond NH S a bond Q3b OH762 N O Q1p a bond H a bond NH S a bond Q3c OH 763 N O Q1p a bond H abond NH O NH Q3a OH 764 N O Q1p a bond H a bond NH O NH Q3b OH 765 N OQ1p a bond H a bond NH O NH Q3c OH 766 N O Q1p a bond H a bond NH O abond Q3a OH 767 N O Q1p a bond H a bond NH O a bond Q3b OH 768 N O Q1p abond H a bond NH O a bond Q3c OH 769 N O Q1q a bond Me a bond NH S NHQ3a OH 770 N O Q1q a bond Me a bond NH S NH Q3b OH 771 N O Q1q a bond Mea bond NH S NH Q3c OH 772 N O Q1q a bond Me a bond NH S a bond Q3a OH773 N O Q1q a bond Me a bond NH S a bond Q3b OH 774 N O Q1q a bond Me abond NH S a bond Q3c OH 775 N O Q1q a bond Me a bond NH O NH Q3a OH 776N O Q1q a bond Me a bond NH O NH Q3b OH 777 N O Q1q a bond Me a bond NHO NH Q3c OH 778 N O Q1q a bond Me a bond NH O a bond Q3a OH 779 N O Q1qa bond Me a bond NH O a bond Q3b OH 780 N O Q1q a bond Me a bond NH O abond Q3c OH 781 N O Q1q a bond H a bond NH S NH Q3a OH 782 N O Q1q abond H a bond NH S NH Q3b OH 783 N O Q1q a bond H a bond NH S NH Q3c OH784 N O Q1q a bond H a bond NH S a bond Q3a OH 785 N O Q1q a bond H abond NH S a bond Q3b OH 786 N O Q1q a bond H a bond NH S a bond Q3c OH787 N O Q1q a bond H a bond NH O NH Q3a OH 788 N O Q1q a bond H a bondNH O NH Q3b OH 789 N O Q1q a bond H a bond NH O NH Q3c OH 790 N O Q1q abond H a bond NH O a bond Q3a OH 791 N O Q1q a bond H a bond NH O a bondQ3b OH 792 N O Q1q a bond H a bond NH O a bond Q3c OH 793 N O Q1r a bondMe a bond NH S NH Q3a OH 794 N O Q1r a bond Me a bond NH S NH Q3b OH 795N O Q1r a bond Me a bond NH S NH Q3c OH 796 N O Q1r a bond Me a bond NHS a bond Q3a OH 797 N O Q1r a bond Me a bond NH S a bond Q3b OH 798 N OQ1r a bond Me a bond NH S a bond Q3c OH 799 N O Q1r a bond Me a bond NHO NH Q3a OH 800 N O Q1r a bond Me a bond NH O NH Q3b OH 801 N O Q1r abond Me a bond NH O NH Q3c OH 802 N O Q1r a bond Me a bond NH O a bondQ3a OH 803 N O Q1r a bond Me a bond NH O a bond Q3b OH 804 N O Q1r abond Me a bond NH O a bond Q3c OH 805 N O Q1r a bond H a bond NH S NHQ3a OH 806 N O Q1r a bond H a bond NH S NH Q3b OH 807 N O Q1r a bond H abond NH S NH Q3c OH 808 N O Q1r a bond H a bond NH S a bond Q3a OH 809 NO Q1r a bond H a bond NH S a bond Q3b OH 810 N O Q1r a bond H a bond NHS a bond Q3c OH 811 N O Q1r a bond H a bond NH O NH Q3a OH 812 N O Q1r abond H a bond NH O NH Q3b OH 813 N O Q1r a bond H a bond NH O NH Q3c OH814 N O Q1r a bond H a bond NH O a bond Q3a OH 815 N O Q1r a bond H abond NH O a bond Q3b OH 816 N O Q1r a bond H a bond NH O a bond Q3c OH817 N O Q1s a bond Me a bond NH S NH Q3a OH 818 N O Q1s a bond Me a bondNH S NH Q3b OH 819 N O Q1s a bond Me a bond NH S NH Q3c OH 820 N O Q1s abond Me a bond NH S a bond Q3a OH 821 N O Q1s a bond Me a bond NH S abond Q3b OH 822 N O Q1s a bond Me a bond NH S a bond Q3c OH 823 N O Q1sa bond Me a bond NH O NH Q3a OH 824 N O Q1s a bond Me a bond NH O NH Q3bOH 825 N O Q1s a bond Me a bond NH O NH Q3c OH 826 N O Q1s a bond Me abond NH O a bond Q3a OH 827 N O Q1s a bond Me a bond NH O a bond Q3b OH828 N O Q1s a bond Me a bond NH O a bond Q3c OH 829 N O Q1s a bond H abond NH S NH Q3a OH 830 N O Q1s a bond H a bond NH S NH Q3b OH 831 N OQ1s a bond H a bond NH S NH Q3c OH 832 N O Q1s a bond H a bond NH S abond Q3a OH 833 N O Q1s a bond H a bond NH S a bond Q3b OH 834 N O Q1s abond H a bond NH S a bond Q3c OH 835 N O Q1s a bond H a bond NH O NH Q3aOH 836 N O Q1s a bond H a bond NH O NH Q3b OH 837 N O Q1s a bond H abond NH O NH Q3c OH 838 N O Q1s a bond H a bond NH O a bond Q3a OH 839 NO Q1s a bond H a bond NH O a bond Q3b OH 840 N O Q1s a bond H a bond NHO a bond Q3c OH 841 N O Q1t a bond Me a bond NH S NH Q3a OH 842 N O Q1ta bond Me a bond NH S NH Q3b OH 843 N O Q1t a bond Me a bond NH S NH Q3cOH 844 N O Q1t a bond Me a bond NH S a bond Q3a OH 845 N O Q1t a bond Mea bond NH S a bond Q3b OH 846 N O Q1t a bond Me a bond NH S a bond Q3cOH 847 N O Q1t a bond Me a bond NH O NH Q3a OH 848 N O Q1t a bond Me abond NH O NH Q3b OH 849 N O Q1t a bond Me a bond NH O NH Q3c OH 850 N OQ1t a bond Me a bond NH O a bond Q3a OH 851 N O Q1t a bond Me a bond NHO a bond Q3b OH 852 N O Q1t a bond Me a bond NH O a bond Q3c OH 853 N OQ1t a bond H a bond NH S NH Q3a OH 854 N O Q1t a bond H a bond NH S NHQ3b OH 855 N O Q1t a bond H a bond NH S NH Q3c OH 856 N O Q1t a bond H abond NH S a bond Q3a OH 857 N O Q1t a bond H a bond NH S a bond Q3b OH858 N O Q1t a bond H a bond NH S a bond Q3c OH 859 N O Q1t a bond H abond NH O NH Q3a OH 860 N O Q1t a bond H a bond NH O NH Q3b OH 861 N OQ1t a bond H a bond NH O NH Q3c OH 862 N O Q1t a bond H a bond NH O abond Q3a OH 863 N O Q1t a bond H a bond NH O a bond Q3b OH 864 N O Q1t abond H a bond NH O a bond Q3c OH 865 N O Q1u a bond Me a bond NH S NHQ3a OH 866 N O Q1u a bond Me a bond NH S NH Q3b OH 867 N O Q1u a bond Mea bond NH S NH Q3c OH 868 N O Q1u a bond Me a bond NH S a bond Q3a OH869 N O Q1u a bond Me a bond NH S a bond Q3b OH 870 N O Q1u a bond Me abond NH S a bond Q3c OH 871 N O Q1u a bond Me a bond NH O NH Q3a OH 872N O Q1u a bond Me a bond NH O NH Q3b OH 873 N O Q1u a bond Me a bond NHO NH Q3c OH 874 N O Q1u a bond Me a bond NH O a bond Q3a OH 875 N O Q1ua bond Me a bond NH O a bond Q3b OH 876 N O Q1u a bond Me a bond NH O abond Q3c OH 877 N O Q1u a bond H a bond NH S NH Q3a OH 878 N O Q1u abond H a bond NH S NH Q3b OH 879 N O Q1u a bond H a bond NH S NH Q3c OH880 N O Q1u a bond H a bond NH S a bond Q3a OH 881 N O Q1u a bond H abond NH S a bond Q3b OH 882 N O Q1u a bond H a bond NH S a bond Q3c OH883 N O Q1u a bond H a bond NH O NH Q3a OH 884 N O Q1u a bond H a bondNH O NH Q3b OH 885 N O Q1u a bond H a bond NH O NH Q3c OH 886 N O Q1u abond H a bond NH O a bond Q3a OH 887 N O Q1u a bond H a bond NH O a bondQ3b OH 888 N O Q1u a bond H a bond NH O a bond Q3c OH 889 N O Q1v a bondMe a bond NH S NH Q3a OH 890 N O Q1v a bond Me a bond NH S NH Q3b OH 891N O Q1v a bond Me a bond NH S NH Q3c OH 892 N O Q1v a bond Me a bond NHS a bond Q3a OH 893 N O Q1v a bond Me a bond NH S a bond Q3b OH 894 N OQ1v a bond Me a bond NH S a bond Q3c OH 895 N O Q1v a bond Me a bond NHO NH Q3a OH 896 N O Q1v a bond Me a bond NH O NH Q3b OH 897 N O Q1v abond Me a bond NH O NH Q3c OH 898 N O Q1v a bond Me a bond NH O a bondQ3a OH 899 N O Q1v a bond Me a bond NH O a bond Q3b OH 900 N O Q1v abond Me a bond NH O a bond Q3c OH 901 N O Q1v a bond H a bond NH S NHQ3a OH 902 N O Q1v a bond H a bond NH S NH Q3b OH 903 N O Q1v a bond H abond NH S NH Q3c OH 904 N O Q1v a bond H a bond NH S a bond Q3a OH 905 NO Q1v a bond H a bond NH S a bond Q3b OH 906 N O Q1v a bond H a bond NHS a bond Q3c OH 907 N O Q1v a bond H a bond NH O NH Q3a OH 908 N O Q1v abond H a bond NH O NH Q3b OH 909 N O Q1v a bond H a bond NH O NH Q3c OH910 N O Q1v a bond H a bond NH O a bond Q3a OH 911 N O Q1v a bond H abond NH O a bond Q3b OH 912 N O Q1v a bond H a bond NH O a bond Q3c OH913 N O Q1w a bond Me a bond NH S NH Q3a OH 914 N O Q1w a bond Me a bondNH S NH Q3b OH 915 N O Q1w a bond Me a bond NH S NH Q3c OH 916 N O Q1w abond Me a bond NH S a bond Q3a OH 917 N O Q1w a bond Me a bond NH S abond Q3b OH 918 N O Q1w a bond Me a bond NH S a bond Q3c OH 919 N O Q1wa bond Me a bond NH O NH Q3a OH 920 N O Q1w a bond Me a bond NH O NH Q3bOH 921 N O Q1w a bond Me a bond NH O NH Q3c OH 922 N O Q1w a bond Me abond NH O a bond Q3a OH 923 N O Q1w a bond Me a bond NH O a bond Q3b OH924 N O Q1w a bond Me a bond NH O a bond Q3c OH 925 N O Q1w a bond H abond NH S NH Q3a OH 926 N O Q1w a bond H a bond NH S NH Q3b OH 927 N OQ1w a bond H a bond NH S NH Q3c OH 928 N O Q1w a bond H a bond NH S abond Q3a OH 929 N O Q1w a bond H a bond NH S a bond Q3b OH 930 N O Q1w abond H a bond NH S a bond Q3c OH 931 N O Q1w a bond H a bond NH O NH Q3aOH 932 N O Q1w a bond H a bond NH O NH Q3b OH 933 N O Q1w a bond H abond NH O NH Q3c OH 934 N O Q1w a bond H a bond NH O a bond Q3a OH 935 NO Q1w a bond H a bond NH O a bond Q3b OH 936 N O Q1w a bond H a bond NHO a bond Q3c OH 937 N O Q1x a bond Me a bond NH S NH Q3a OH 938 N O Q1xa bond Me a bond NH S NH Q3b OH 939 N O Q1x a bond Me a bond NH S NH Q3cOH 940 N O Q1x a bond Me a bond NH S a bond Q3a OH 941 N O Q1x a bond Mea bond NH S a bond Q3b OH 942 N O Q1x a bond Me a bond NH S a bond Q3cOH 943 N O Q1x a bond Me a bond NH O NH Q3a OH 944 N O Q1x a bond Me abond NH O NH Q3b OH 945 N O Q1x a bond Me a bond NH O NH Q3c OH 946 N OQ1x a bond Me a bond NH O a bond Q3a OH 947 N O Q1x a bond Me a bond NHO a bond Q3b OH 948 N O Q1x a bond Me a bond NH O a bond Q3c OH 949 N OQ1x a bond H a bond NH S NH Q3a OH 950 N O Q1x a bond H a bond NH S NHQ3b OH 951 N O Q1x a bond H a bond NH S NH Q3c OH 952 N O Q1x a bond H abond NH S a bond Q3a OH 953 N O Q1x a bond H a bond NH S a bond Q3b OH954 N O Q1x a bond H a bond NH S a bond Q3c OH 955 N O Q1x a bond H abond NH O NH Q3a OH 956 N O Q1x a bond H a bond NH O NH Q3b OH 957 N OQ1x a bond H a bond NH O NH Q3c OH 958 N O Q1x a bond H a bond NH O abond Q3a OH 959 N O Q1x a bond H a bond NH O a bond Q3b OH 960 N O Q1x abond H a bond NH O a bond Q3c OH 961 CH NMe Q1o a bond Me a bond NH S NHQ3a OH 962 CH NMe Q1o a bond Me a bond NH S NH Q3b OH 963 CH NMe Q1o abond Me a bond NH S NH Q3c OH 964 CH NMe Q1o a bond Me a bond NH S abond Q3a OH 965 CH NMe Q1o a bond Me a bond NH S a bond Q3b OH 966 CHNMe Q1o a bond Me a bond NH S a bond Q3c OH 967 CH NMe Q1o a bond Me abond NH O NH Q3a OH 968 CH NMe Q1o a bond Me a bond NH O NH Q3b OH 969CH NMe Q1o a bond Me a bond NH O NH Q3c OH 970 CH NMe Q1o a bond Me abond NH O a bond Q3a OH 971 CH NMe Q1o a bond Me a bond NH O a bond Q3bOH 972 CH NMe Q1o a bond Me a bond NH O a bond Q3c OH 973 CH NMe Q1o abond H a bond NH S NH Q3a OH 974 CH NMe Q1o a bond H a bond NH S NH Q3bOH 975 CH NMe Q1o a bond H a bond NH S NH Q3c OH 976 CH NMe Q1o a bond Ha bond NH S a bond Q3a OH 977 CH NMe Q1o a bond H a bond NH S a bond Q3bOH 978 CH NMe Q1o a bond H a bond NH S a bond Q3c OH 979 CH NMe Q1o abond H a bond NH O NH Q3a OH 980 CH NMe Q1o a bond H a bond NH O NH Q3bOH 981 CH NMe Q1o a bond H a bond NH O NH Q3c OH 982 CH NMe Q1o a bond Ha bond NH O a bond Q3a OH 983 CH NMe Q1o a bond H a bond NH O a bond Q3bOH 984 CH NMe Q1o a bond H a bond NH O a bond Q3c OH 985 CH NMe Q1p abond Me a bond NH S NH Q3a OH 986 CH NMe Q1p a bond Me a bond NH S NHQ3b OH 987 CH NMe Q1p a bond Me a bond NH S NH Q3c OH 988 CH NMe Q1p abond Me a bond NH S a bond Q3a OH 989 CH NMe Q1p a bond Me a bond NH S abond Q3b OH 990 CH NMe Q1p a bond Me a bond NH S a bond Q3c OH 991 CHNMe Q1p a bond Me a bond NH O NH Q3a OH 992 CH NMe Q1p a bond Me a bondNH O NH Q3b OH 993 CH NMe Q1p a bond Me a bond NH O NH Q3c OH 994 CH NMeQ1p a bond Me a bond NH O a bond Q3a OH 995 CH NMe Q1p a bond Me a bondNH O a bond Q3b OH 996 CH NMe Q1p a bond Me a bond NH O a bond Q3c OH997 CH NMe Q1p a bond H a bond NH S NH Q3a OH 998 CH NMe Q1p a bond H abond NH S NH Q3b OH 999 CH NMe Q1p a bond H a bond NH S NH Q3c OH 1000CH NMe Q1p a bond H a bond NH S a bond Q3a OH 1001 CH NMe Q1p a bond H abond NH S a bond Q3b OH 1002 CH NMe Q1p a bond H a bond NH S a bond Q3cOH 1003 CH NMe Q1p a bond H a bond NH O NH Q3a OH 1004 CH NMe Q1p a bondH a bond NH O NH Q3b OH 1005 CH NMe Q1p a bond H a bond NH O NH Q3c OH1006 CH NMe Q1p a bond H a bond NH O a bond Q3a OH 1007 CH NMe Q1p abond H a bond NH O a bond Q3b OH 1008 CH NMe Q1p a bond H a bond NH O abond Q3c OH 1009 CH NMe Q1q a bond Me a bond NH S NH Q3a OH 1010 CH NMeQ1q a bond Me a bond NH S NH Q3b OH 1011 CH NMe Q1q a bond Me a bond NHS NH Q3c OH 1012 CH NMe Q1q a bond Me a bond NH S a bond Q3a OH 1013 CHNMe Q1q a bond Me a bond NH S a bond Q3b OH 1014 CH NMe Q1q a bond Me abond NH S a bond Q3c OH 1015 CH NMe Q1q a bond Me a bond NH O NH Q3a OH1016 CH NMe Q1q a bond Me a bond NH O NH Q3b OH 1017 CH NMe Q1q a bondMe a bond NH O NH Q3c OH 1018 CH NMe Q1q a bond Me a bond NH O a bondQ3a OH 1019 CH NMe Q1q a bond Me a bond NH O a bond Q3b OH 1020 CH NMeQ1q a bond Me a bond NH O a bond Q3c OH 1021 CH NMe Q1q a bond H a bondNH S NH Q3a OH 1022 CH NMe Q1q a bond H a bond NH S NH Q3b OH 1023 CHNMe Q1q a bond H a bond NH S NH Q3c OH 1024 CH NMe Q1q a bond H a bondNH S a bond Q3a OH 1025 CH NMe Q1q a bond H a bond NH S a bond Q3b OH1026 CH NMe Q1q a bond H a bond NH S a bond Q3c OH 1027 CH NMe Q1q abond H a bond NH O NH Q3a OH 1028 CH NMe Q1q a bond H a bond NH O NH Q3bOH 1029 CH NMe Q1q a bond H a bond NH O NH Q3c OH 1030 CH NMe Q1q a bondH a bond NH O a bond Q3a OH 1031 CH NMe Q1q a bond H a bond NH O a bondQ3b OH 1032 CH NMe Q1q a bond H a bond NH O a bond Q3c OH 1033 CH NMeQ1r a bond Me a bond NH S NH Q3a OH 1034 CH NMe Q1r a bond Me a bond NHS NH Q3b OH 1035 CH NMe Q1r a bond Me a bond NH S NH Q3c OH 1036 CH NMeQ1r a bond Me a bond NH S a bond Q3a OH 1037 CH NMe Q1r a bond Me a bondNH S a bond Q3b OH 1038 CH NMe Q1r a bond Me a bond NH S a bond Q3c OH1039 CH NMe Q1r a bond Me a bond NH O NH Q3a OH 1040 CH NMe Q1r a bondMe a bond NH O NH Q3b OH 1041 CH NMe Q1r a bond Me a bond NH O NH Q3c OH1042 CH NMe Q1r a bond Me a bond NH O a bond Q3a OH 1043 CH NMe Q1r abond Me a bond NH O a bond Q3b OH 1044 CH NMe Q1r a bond Me a bond NH Oa bond Q3c OH 1045 CH NMe Q1r a bond H a bond NH S NH Q3a OH 1046 CH NMeQ1r a bond H a bond NH S NH Q3b OH 1047 CH NMe Q1r a bond H a bond NH SNH Q3c OH 1048 CH NMe Q1r a bond H a bond NH S a bond Q3a OH 1049 CH NMeQ1r a bond H a bond NH S a bond Q3b OH 1050 CH NMe Q1r a bond H a bondNH S a bond Q3c OH 1051 CH NMe Q1r a bond H a bond NH O NH Q3a OH 1052CH NMe Q1r a bond H a bond NH O NH Q3b OH 1053 CH NMe Q1r a bond H abond NH O NH Q3c OH 1054 CH NMe Q1r a bond H a bond NH O a bond Q3a OH1055 CH NMe Q1r a bond H a bond NH O a bond Q3b OH 1056 CH NMe Q1r abond H a bond NH O a bond Q3c OH 1057 CH NMe Q1s a bond Me a bond NH SNH Q3a OH 1058 CH NMe Q1s a bond Me a bond NH S NH Q3b OH 1059 CH NMeQ1s a bond Me a bond NH S NH Q3c OH 1060 CH NMe Q1s a bond Me a bond NHS a bond Q3a OH 1061 CH NMe Q1s a bond Me a bond NH S a bond Q3b OH 1062CH NMe Q1s a bond Me a bond NH S a bond Q3c OH 1063 CH NMe Q1s a bond Mea bond NH O NH Q3a OH 1064 CH NMe Q1s a bond Me a bond NH O NH Q3b OH1065 CH NMe Q1s a bond Me a bond NH O NH Q3c OH 1066 CH NMe Q1s a bondMe a bond NH O a bond Q3a OH 1067 CH NMe Q1s a bond Me a bond NH O abond Q3b OH 1068 CH NMe Q1s a bond Me a bond NH O a bond Q3c OH 1069 CHNMe Q1s a bond H a bond NH S NH Q3a OH 1070 CH NMe Q1s a bond H a bondNH S NH Q3b OH 1071 CH NMe Q1s a bond H a bond NH S NH Q3c OH 1072 CHNMe Q1s a bond H a bond NH S a bond Q3a OH 1073 CH NMe Q1s a bond H abond NH S a bond Q3b OH 1074 CH NMe Q1s a bond H a bond NH S a bond Q3cOH 1075 CH NMe Q1s a bond H a bond NH O NH Q3a OH 1076 CH NMe Q1s a bondH a bond NH O NH Q3b OH 1077 CH NMe Q1s a bond H a bond NH O NH Q3c OH1078 CH NMe Q1s a bond H a bond NH O a bond Q3a OH 1079 CH NMe Q1s abond H a bond NH O a bond Q3b OH 1080 CH NMe Q1s a bond H a bond NH O abond Q3c OH 1081 CH NMe Q1t a bond Me a bond NH S NH Q3a OH 1082 CH NMeQ1t a bond Me a bond NH S NH Q3b OH 1083 CH NMe Q1t a bond Me a bond NHS NH Q3c OH 1084 CH NMe Q1t a bond Me a bond NH S a bond Q3a OH 1085 CHNMe Q1t a bond Me a bond NH S a bond Q3b OH 1086 CH NMe Q1t a bond Me abond NH S a bond Q3c OH 1087 CH NMe Q1t a bond Me a bond NH O NH Q3a OH1088 CH NMe Q1t a bond Me a bond NH O NH Q3b OH 1089 CH NMe Q1t a bondMe a bond NH O NH Q3c OH 1090 CH NMe Q1t a bond Me a bond NH O a bondQ3a OH 1091 CH NMe Q1t a bond Me a bond NH O a bond Q3b OH 1092 CH NMeQ1t a bond Me a bond NH O a bond Q3c OH 1093 CH NMe Q1t a bond H a bondNH S NH Q3a OH 1094 CH NMe Q1t a bond H a bond NH S NH Q3b OH 1095 CHNMe Q1t a bond H a bond NH S NH Q3c OH 1096 CH NMe Q1t a bond H a bondNH S a bond Q3a OH 1097 CH NMe Q1t a bond H a bond NH S a bond Q3b OH1098 CH NMe Q1t a bond H a bond NH S a bond Q3c OH 1099 CH NMe Q1t abond H a bond NH O NH Q3a OH 1100 CH NMe Q1t a bond H a bond NH O NH Q3bOH 1101 CH NMe Q1t a bond H a bond NH O NH Q3c OH 1102 CH NMe Q1t a bondH a bond NH O a bond Q3a OH 1103 CH NMe Q1t a bond H a bond NH O a bondQ3b OH 1104 CH NMe Q1t a bond H a bond NH O a bond Q3c OH 1105 CH NMeQ1u a bond Me a bond NH S NH Q3a OH 1106 CH NMe Q1u a bond Me a bond NHS NH Q3b OH 1107 CH NMe Q1u a bond Me a bond NH S NH Q3c OH 1108 CH NMeQ1u a bond Me a bond NH S a bond Q3a OH 1109 CH NMe Q1u a bond Me a bondNH S a bond Q3b OH 1110 CH NMe Q1u a bond Me a bond NH S a bond Q3c OH1111 CH NMe Q1u a bond Me a bond NH O NH Q3a OH 1112 CH NMe Q1u a bondMe a bond NH O NH Q3b OH 1113 CH NMe Q1u a bond Me a bond NH O NH Q3c OH1114 CH NMe Q1u a bond Me a bond NH O a bond Q3a OH 1115 CH NMe Q1u abond Me a bond NH O a bond Q3b OH 1116 CH NMe Q1u a bond Me a bond NH Oa bond Q3c OH 1117 CH NMe Q1u a bond H a bond NH S NH Q3a OH 1118 CH NMeQ1u a bond H a bond NH S NH Q3b OH 1119 CH NMe Q1u a bond H a bond NH SNH Q3c OH 1120 CH NMe Q1u a bond H a bond NH S a bond Q3a OH 1121 CH NMeQ1u a bond H a bond NH S a bond Q3b OH 1122 CH NMe Q1u a bond H a bondNH S a bond Q3c OH 1123 CH NMe Q1u a bond H a bond NH O NH Q3a OH 1124CH NMe Q1u a bond H a bond NH O NH Q3b OH 1125 CH NMe Q1u a bond H abond NH O NH Q3c OH 1126 CH NMe Q1u a bond H a bond NH O a bond Q3a OH1127 CH NMe Q1u a bond H a bond NH O a bond Q3b OH 1128 CH NMe Q1u abond H a bond NH O a bond Q3c OH 1129 CH NMe Q1v a bond Me a bond NH SNH Q3a OH 1130 CH NMe Q1v a bond Me a bond NH S NH Q3b OH 1131 CH NMeQ1v a bond Me a bond NH S NH Q3c OH 1132 CH NMe Q1v a bond Me a bond NHS a bond Q3a OH 1133 CH NMe Q1v a bond Me a bond NH S a bond Q3b OH 1134CH NMe Q1v a bond Me a bond NH S a bond Q3c OH 1135 CH NMe Q1v a bond Mea bond NH O NH Q3a OH 1136 CH NMe Q1v a bond Me a bond NH O NH Q3b OH1137 CH NMe Q1v a bond Me a bond NH O NH Q3c OH 1138 CH NMe Q1v a bondMe a bond NH O a bond Q3a OH 1139 CH NMe Q1v a bond Me a bond NH O abond Q3b OH 1140 CH NMe Q1v a bond Me a bond NH O a bond Q3c OH 1141 CHNMe Q1v a bond H a bond NH S NH Q3a OH 1142 CH NMe Q1v a bond H a bondNH S NH Q3b OH 1143 CH NMe Q1v a bond H a bond NH S NH Q3c OH 1144 CHNMe Q1v a bond H a bond NH S a bond Q3a OH 1145 CH NMe Q1v a bond H abond NH S a bond Q3b OH 1146 CH NMe Q1v a bond H a bond NH S a bond Q3cOH 1147 CH NMe Q1v a bond H a bond NH O NH Q3a OH 1148 CH NMe Q1v a bondH a bond NH O NH Q3b OH 1149 CH NMe Q1v a bond H a bond NH O NH Q3c OH1150 CH NMe Q1v a bond H a bond NH O a bond Q3a OH 1151 CH NMe Q1v abond H a bond NH O a bond Q3b OH 1152 CH NMe Q1v a bond H a bond NH O abond Q3c OH 1153 CH NMe Q1w a bond Me a bond NH S NH Q3a OH 1154 CH NMeQ1w a bond Me a bond NH S NH Q3b OH 1155 CH NMe Q1w a bond Me a bond NHS NH Q3c OH 1156 CH NMe Q1w a bond Me a bond NH S a bond Q3a OH 1157 CHNMe Q1w a bond Me a bond NH S a bond Q3b OH 1158 CH NMe Q1w a bond Me abond NH S a bond Q3c OH 1159 CH NMe Q1w a bond Me a bond NH O NH Q3a OH1160 CH NMe Q1w a bond Me a bond NH O NH Q3b OH 1161 CH NMe Q1w a bondMe a bond NH O NH Q3c OH 1162 CH NMe Q1w a bond Me a bond NH O a bondQ3a OH 1163 CH NMe Q1w a bond Me a bond NH O a bond Q3b OH 1164 CH NMeQ1w a bond Me a bond NH O a bond Q3c OH 1165 CH NMe Q1w a bond H a bondNH S NH Q3a OH 1166 CH NMe Q1w a bond H a bond NH S NH Q3b OH 1167 CHNMe Q1w a bond H a bond NH S NH Q3c OH 1168 CH NMe Q1w a bond H a bondNH S a bond Q3a OH 1169 CH NMe Q1w a bond H a bond NH S a bond Q3b OH1170 CH NMe Q1w a bond H a bond NH S a bond Q3c OH 1171 CH NMe Q1w abond H a bond NH O NH Q3a OH 1172 CH NMe Q1w a bond H a bond NH O NH Q3bOH 1173 CH NMe Q1w a bond H a bond NH O NH Q3c OH 1174 CH NMe Q1w a bondH a bond NH O a bond Q3a OH 1175 CH NMe Q1w a bond H a bond NH O a bondQ3b OH 1176 CH NMe Q1w a bond H a bond NH O a bond Q3c OH 1177 CH NMeQ1x a bond Me a bond NH S NH Q3a OH 1178 CH NMe Q1x a bond Me a bond NHS NH Q3b OH 1179 CH NMe Q1x a bond Me a bond NH S NH Q3c OH 1180 CH NMeQ1x a bond Me a bond NH S a bond Q3a OH 1181 CH NMe Q1x a bond Me a bondNH S a bond Q3b OH 1182 CH NMe Q1x a bond Me a bond NH S a bond Q3c OH1183 CH NMe Q1x a bond Me a bond NH O NH Q3a OH 1184 CH NMe Q1x a bondMe a bond NH O NH Q3b OH 1185 CH NMe Q1x a bond Me a bond NH O NH Q3c OH1186 CH NMe Q1x a bond Me a bond NH O a bond Q3a OH 1187 CH NMe Q1x abond Me a bond NH O a bond Q3b OH 1188 CH NMe Q1x a bond Me a bond NH Oa bond Q3c OH 1189 CH NMe Q1x a bond H a bond NH S NH Q3a OH 1190 CH NMeQ1x a bond H a bond NH S NH Q3b OH 1191 CH NMe Q1x a bond H a bond NH SNH Q3c OH 1192 CH NMe Q1x a bond H a bond NH S a bond Q3a OH 1193 CH NMeQ1x a bond H a bond NH S a bond Q3b OH 1194 CH NMe Q1x a bond H a bondNH S a bond Q3c OH 1195 CH NMe Q1x a bond H a bond NH O NH Q3a OH 1196CH NMe Q1x a bond H a bond NH O NH Q3b OH 1197 CH NMe Q1x a bond H abond NH O NH Q3c OH 1198 CH NMe Q1x a bond H a bond NH O a bond Q3a OH1199 CH NMe Q1x a bond H a bond NH O a bond Q3b OH 1200 CH NMe Q1x abond H a bond NH O a bond Q3c OH 1201 CH NEt Q1o a bond Me a bond NH SNH Q3a OH 1202 CH NEt Q1o a bond Me a bond NH S NH Q3b OH 1203 CH NEtQ1o a bond Me a bond NH S NH Q3c OH 1204 CH NEt Q1o a bond Me a bond NHS a bond Q3a OH 1205 CH NEt Q1o a bond Me a bond NH S a bond Q3b OH 1206CH NEt Q1o a bond Me a bond NH S a bond Q3c OH 1207 CH NEt Q1o a bond Mea bond NH O NH Q3a OH 1208 CH NEt Q1o a bond Me a bond NH O NH Q3b OH1209 CH NEt Q1o a bond Me a bond NH O NH Q3c OH 1210 CH NEt Q1o a bondMe a bond NH O a bond Q3a OH 1211 CH NEt Q1o a bond Me a bond NH O abond Q3b OH 1212 CH NEt Q1o a bond Me a bond NH O a bond Q3c OH 1213 CHNEt Q1o a bond H a bond NH S NH Q3a OH 1214 CH NEt Q1o a bond H a bondNH S NH Q3b OH 1215 CH NEt Q1o a bond H a bond NH S NH Q3c OH 1216 CHNEt Q1o a bond H a bond NH S a bond Q3a OH 1217 CH NEt Q1o a bond H abond NH S a bond Q3b OH 1218 CH NEt Q1o a bond H a bond NH S a bond Q3cOH 1219 CH NEt Q1o a bond H a bond NH O NH Q3a OH 1220 CH NEt Q1o a bondH a bond NH O NH Q3b OH 1221 CH NEt Q1o a bond H a bond NH O NH Q3c OH1222 CH NEt Q1o a bond H a bond NH O a bond Q3a OH 1223 CH NEt Q1o abond H a bond NH O a bond Q3b OH 1224 CH NEt Q1o a bond H a bond NH O abond Q3c OH 1225 CH NEt Q1p a bond Me a bond NH S NH Q3a OH 1226 CH NEtQ1p a bond Me a bond NH S NH Q3b OH 1227 CH NEt Q1p a bond Me a bond NHS NH Q3c OH 1228 CH NEt Q1p a bond Me a bond NH S a bond Q3a OH 1229 CHNEt Q1p a bond Me a bond NH S a bond Q3b OH 1230 CH NEt Q1p a bond Me abond NH S a bond Q3c OH 1231 CH NEt Q1p a bond Me a bond NH O NH Q3a OH1232 CH NEt Q1p a bond Me a bond NH O NH Q3b OH 1233 CH NEt Q1p a bondMe a bond NH O NH Q3c OH 1234 CH NEt Q1p a bond Me a bond NH O a bondQ3a OH 1235 CH NEt Q1p a bond Me a bond NH O a bond Q3b OH 1236 CH NEtQ1p a bond Me a bond NH O a bond Q3c OH 1237 CH NEt Q1p a bond H a bondNH S NH Q3a OH 1238 CH NEt Q1p a bond H a bond NH S NH Q3b OH 1239 CHNEt Q1p a bond H a bond NH S NH Q3c OH 1240 CH NEt Q1p a bond H a bondNH S a bond Q3a OH 1241 CH NEt Q1p a bond H a bond NH S a bond Q3b OH1242 CH NEt Q1p a bond H a bond NH S a bond Q3c OH 1243 CH NEt Q1p abond H a bond NH O NH Q3a OH 1244 CH NEt Q1p a bond H a bond NH O NH Q3bOH 1245 CH NEt Q1p a bond H a bond NH O NH Q3c OH 1246 CH NEt Q1p a bondH a bond NH O a bond Q3a OH 1247 CH NEt Q1p a bond H a bond NH O a bondQ3b OH 1248 CH NEt Q1p a bond H a bond NH O a bond Q3c OH 1249 CH NEtQ1q a bond Me a bond NH S NH Q3a OH 1250 CH NEt Q1q a bond Me a bond NHS NH Q3b OH 1251 CH NEt Q1q a bond Me a bond NH S NH Q3c OH 1252 CH NEtQ1q a bond Me a bond NH S a bond Q3a OH 1253 CH NEt Q1q a bond Me a bondNH S a bond Q3b OH 1254 CH NEt Q1q a bond Me a bond NH S a bond Q3c OH1255 CH NEt Q1q a bond Me a bond NH O NH Q3a OH 1256 CH NEt Q1q a bondMe a bond NH O NH Q3b OH 1257 CH NEt Q1q a bond Me a bond NH O NH Q3c OH1258 CH NEt Q1q a bond Me a bond NH O a bond Q3a OH 1259 CH NEt Q1q abond Me a bond NH O a bond Q3b OH 1260 CH NEt Q1q a bond Me a bond NH Oa bond Q3c OH 1261 CH NEt Q1q a bond H a bond NH S NH Q3a OH 1262 CH NEtQ1q a bond H a bond NH S NH Q3b OH 1263 CH NEt Q1q a bond H a bond NH SNH Q3c OH 1264 CH NEt Q1q a bond H a bond NH S a bond Q3a OH 1265 CH NEtQ1q a bond H a bond NH S a bond Q3b OH 1266 CH NEt Q1q a bond H a bondNH S a bond Q3c OH 1267 CH NEt Q1q a bond H a bond NH O NH Q3a OH 1268CH NEt Q1q a bond H a bond NH O NH Q3b OH 1269 CH NEt Q1q a bond H abond NH O NH Q3c OH 1270 CH NEt Q1q a bond H a bond NH O a bond Q3a OH1271 CH NEt Q1q a bond H a bond NH O a bond Q3b OH 1272 CH NEt Q1q abond H a bond NH O a bond Q3c OH 1273 CH NEt Q1r a bond Me a bond NH SNH Q3a OH 1274 CH NEt Q1r a bond Me a bond NH S NH Q3b OH 1275 CH NEtQ1r a bond Me a bond NH S NH Q3c OH 1276 CH NEt Q1r a bond Me a bond NHS a bond Q3a OH 1277 CH NEt Q1r a bond Me a bond NH S a bond Q3b OH 1278CH NEt Q1r a bond Me a bond NH S a bond Q3c OH 1279 CH NEt Q1r a bond Mea bond NH O NH Q3a OH 1280 CH NEt Q1r a bond Me a bond NH O NH Q3b OH1281 CH NEt Q1r a bond Me a bond NH O NH Q3c OH 1282 CH NEt Q1r a bondMe a bond NH O a bond Q3a OH 1283 CH NEt Q1r a bond Me a bond NH O abond Q3b OH 1284 CH NEt Q1r a bond Me a bond NH O a bond Q3c OH 1285 CHNEt Q1r a bond H a bond NH S NH Q3a OH 1286 CH NEt Q1r a bond H a bondNH S NH Q3b OH 1287 CH NEt Q1r a bond H a bond NH S NH Q3c OH 1288 CHNEt Q1r a bond H a bond NH S a bond Q3a OH 1289 CH NEt Q1r a bond H abond NH S a bond Q3b OH 1290 CH NEt Q1r a bond H a bond NH S a bond Q3cOH 1291 CH NEt Q1r a bond H a bond NH O NH Q3a OH 1292 CH NEt Q1r a bondH a bond NH O NH Q3b OH 1293 CH NEt Q1r a bond H a bond NH O NH Q3c OH1294 CH NEt Q1r a bond H a bond NH O a bond Q3a OH 1295 CH NEt Q1r abond H a bond NH O a bond Q3b OH 1296 CH NEt Q1r a bond H a bond NH O abond Q3c OH 1297 CH NEt Q1s a bond Me a bond NH S NH Q3a OH 1298 CH NEtQ1s a bond Me a bond NH S NH Q3b OH 1299 CH NEt Q1s a bond Me a bond NHS NH Q3c OH 1300 CH NEt Q1s a bond Me a bond NH S a bond Q3a OH 1301 CHNEt Q1s a bond Me a bond NH S a bond Q3b OH 1302 CH NEt Q1s a bond Me abond NH S a bond Q3c OH 1303 CH NEt Q1s a bond Me a bond NH O NH Q3a OH1304 CH NEt Q1s a bond Me a bond NH O NH Q3b OH 1305 CH NEt Q1s a bondMe a bond NH O NH Q3c OH 1306 CH NEt Q1s a bond Me a bond NH O a bondQ3a OH 1307 CH NEt Q1s a bond Me a bond NH O a bond Q3b OH 1308 CH NEtQ1s a bond Me a bond NH O a bond Q3c OH 1309 CH NEt Q1s a bond H a bondNH S NH Q3a OH 1310 CH NEt Q1s a bond H a bond NH S NH Q3b OH 1311 CHNEt Q1s a bond H a bond NH S NH Q3c OH 1312 CH NEt Q1s a bond H a bondNH S a bond Q3a OH 1313 CH NEt Q1s a bond H a bond NH S a bond Q3b OH1314 CH NEt Q1s a bond H a bond NH S a bond Q3c OH 1315 CH NEt Q1s abond H a bond NH O NH Q3a OH 1316 CH NEt Q1s a bond H a bond NH O NH Q3bOH 1317 CH NEt Q1s a bond H a bond NH O NH Q3c OH 1318 CH NEt Q1s a bondH a bond NH O a bond Q3a OH 1319 CH NEt Q1s a bond H a bond NH O a bondQ3b OH 1320 CH NEt Q1s a bond H a bond NH O a bond Q3c OH 1321 CH NEtQ1t a bond Me a bond NH S NH Q3a OH 1322 CH NEt Q1t a bond Me a bond NHS NH Q3b OH 1323 CH NEt Q1t a bond Me a bond NH S NH Q3c OH 1324 CH NEtQ1t a bond Me a bond NH S a bond Q3a OH 1325 CH NEt Q1t a bond Me a bondNH S a bond Q3b OH 1326 CH NEt Q1t a bond Me a bond NH S a bond Q3c OH1327 CH NEt Q1t a bond Me a bond NH O NH Q3a OH 1328 CH NEt Q1t a bondMe a bond NH O NH Q3b OH 1329 CH NEt Q1t a bond Me a bond NH O NH Q3c OH1330 CH NEt Q1t a bond Me a bond NH O a bond Q3a OH 1331 CH NEt Q1t abond Me a bond NH O a bond Q3b OH 1332 CH NEt Q1t a bond Me a bond NH Oa bond Q3c OH 1333 CH NEt Q1t a bond H a bond NH S NH Q3a OH 1334 CH NEtQ1t a bond H a bond NH S NH Q3b OH 1335 CH NEt Q1t a bond H a bond NH SNH Q3c OH 1336 CH NEt Q1t a bond H a bond NH S a bond Q3a OH 1337 CH NEtQ1t a bond H a bond NH S a bond Q3b OH 1338 CH NEt Q1t a bond H a bondNH S a bond Q3c OH 1339 CH NEt Q1t a bond H a bond NH O NH Q3a OH 1340CH NEt Q1t a bond H a bond NH O NH Q3b OH 1341 CH NEt Q1t a bond H abond NH O NH Q3c OH 1342 CH NEt Q1t a bond H a bond NH O a bond Q3a OH1343 CH NEt Q1t a bond H a bond NH O a bond Q3b OH 1344 CH NEt Q1t abond H a bond NH O a bond Q3c OH 1345 CH NEt Q1u a bond Me a bond NH SNH Q3a OH 1346 CH NEt Q1u a bond Me a bond NH S NH Q3b OH 1347 CH NEtQ1u a bond Me a bond NH S NH Q3c OH 1348 CH NEt Q1u a bond Me a bond NHS a bond Q3a OH 1349 CH NEt Q1u a bond Me a bond NH S a bond Q3b OH 1350CH NEt Q1u a bond Me a bond NH S a bond Q3c OH 1351 CH NEt Q1u a bond Mea bond NH O NH Q3a OH 1352 CH NEt Q1u a bond Me a bond NH O NH Q3b OH1353 CH NEt Q1u a bond Me a bond NH O NH Q3c OH 1354 CH NEt Q1u a bondMe a bond NH O a bond Q3a OH 1355 CH NEt Q1u a bond Me a bond NH O abond Q3b OH 1356 CH NEt Q1u a bond Me a bond NH O a bond Q3c OH 1357 CHNEt Q1u a bond H a bond NH S NH Q3a OH 1358 CH NEt Q1u a bond H a bondNH S NH Q3b OH 1359 CH NEt Q1u a bond H a bond NH S NH Q3c OH 1360 CHNEt Q1u a bond H a bond NH S a bond Q3a OH 1361 CH NEt Q1u a bond H abond NH S a bond Q3b OH 1362 CH NEt Q1u a bond H a bond NH S a bond Q3cOH 1363 CH NEt Q1u a bond H a bond NH O NH Q3a OH 1364 CH NEt Q1u a bondH a bond NH O NH Q3b OH 1365 CH NEt Q1u a bond H a bond NH O NH Q3c OH1366 CH NEt Q1u a bond H a bond NH O a bond Q3a OH 1367 CH NEt Q1u abond H a bond NH O a bond Q3b OH 1368 CH NEt Q1u a bond H a bond NH O abond Q3c OH 1369 CH NEt Q1v a bond Me a bond NH S NH Q3a OH 1370 CH NEtQ1v a bond Me a bond NH S NH Q3b OH 1371 CH NEt Q1v a bond Me a bond NHS NH Q3c OH 1372 CH NEt Q1v a bond Me a bond NH S a bond Q3a OH 1373 CHNEt Q1v a bond Me a bond NH S a bond Q3b OH 1374 CH NEt Q1v a bond Me abond NH S a bond Q3c OH 1375 CH NEt Q1v a bond Me a bond NH O NH Q3a OH1376 CH NEt Q1v a bond Me a bond NH O NH Q3b OH 1377 CH NEt Q1v a bondMe a bond NH O NH Q3c OH 1378 CH NEt Q1v a bond Me a bond NH O a bondQ3a OH 1379 CH NEt Q1v a bond Me a bond NH O a bond Q3b OH 1380 CH NEtQ1v a bond Me a bond NH O a bond Q3c OH 1381 CH NEt Q1v a bond H a bondNH S NH Q3a OH 1382 CH NEt Q1v a bond H a bond NH S NH Q3b OH 1383 CHNEt Q1v a bond H a bond NH S NH Q3c OH 1384 CH NEt Q1v a bond H a bondNH S a bond Q3a OH 1385 CH NEt Q1v a bond H a bond NH S a bond Q3b OH1386 CH NEt Q1v a bond H a bond NH S a bond Q3c OH 1387 CH NEt Q1v abond H a bond NH O NH Q3a OH 1388 CH NEt Q1v a bond H a bond NH O NH Q3bOH 1389 CH NEt Q1v a bond H a bond NH O NH Q3c OH 1390 CH NEt Q1v a bondH a bond NH O a bond Q3a OH 1391 CH NEt Q1v a bond H a bond NH O a bondQ3b OH 1392 CH NEt Q1v a bond H a bond NH O a bond Q3c OH 1393 CH NEtQ1w a bond Me a bond NH S NH Q3a OH 1394 CH NEt Q1w a bond Me a bond NHS NH Q3b OH 1395 CH NEt Q1w a bond Me a bond NH S NH Q3c OH 1396 CH NEtQ1w a bond Me a bond NH S a bond Q3a OH 1397 CH NEt Q1w a bond Me a bondNH S a bond Q3b OH 1398 CH NEt Q1w a bond Me a bond NH S a bond Q3c OH1399 CH NEt Q1w a bond Me a bond NH O NH Q3a OH 1400 CH NEt Q1w a bondMe a bond NH O NH Q3b OH 1401 CH NEt Q1w a bond Me a bond NH O NH Q3c OH1402 CH NEt Q1w a bond Me a bond NH O a bond Q3a OH 1403 CH NEt Q1w abond Me a bond NH O a bond Q3b OH 1404 CH NEt Q1w a bond Me a bond NH Oa bond Q3c OH 1405 CH NEt Q1w a bond H a bond NH S NH Q3a OH 1406 CH NEtQ1w a bond H a bond NH S NH Q3b OH 1407 CH NEt Q1w a bond H a bond NH SNH Q3c OH 1408 CH NEt Q1w a bond H a bond NH S a bond Q3a OH 1409 CH NEtQ1w a bond H a bond NH S a bond Q3b OH 1410 CH NEt Q1w a bond H a bondNH S a bond Q3c OH 1411 CH NEt Q1w a bond H a bond NH O NH Q3a OH 1412CH NEt Q1w a bond H a bond NH O NH Q3b OH 1413 CH NEt Q1w a bond H abond NH O NH Q3c OH 1414 CH NEt Q1w a bond H a bond NH O a bond Q3a OH1415 CH NEt Q1w a bond H a bond NH O a bond Q3b OH 1416 CH NEt Q1w abond H a bond NH O a bond Q3c OH 1417 CH NEt Q1x a bond Me a bond NH SNH Q3a OH 1418 CH NEt Q1x a bond Me a bond NH S NH Q3b OH 1419 CH NEtQ1x a bond Me a bond NH S NH Q3c OH 1420 CH NEt Q1x a bond Me a bond NHS a bond Q3a OH 1421 CH NEt Q1x a bond Me a bond NH S a bond Q3b OH 1422CH NEt Q1x a bond Me a bond NH S a bond Q3c OH 1423 CH NEt Q1x a bond Mea bond NH O NH Q3a OH 1424 CH NEt Q1x a bond Me a bond NH O NH Q3b OH1425 CH NEt Q1x a bond Me a bond NH O NH Q3c OH 1426 CH NEt Q1x a bondMe a bond NH O a bond Q3a OH 1427 CH NEt Q1x a bond Me a bond NH O abond Q3b OH 1428 CH NEt Q1x a bond Me a bond NH O a bond Q3c OH 1429 CHNEt Q1x a bond H a bond NH S NH Q3a OH 1430 CH NEt Q1x a bond H a bondNH S NH Q3b OH 1431 CH NEt Q1x a bond H a bond NH S NH Q3c OH 1432 CHNEt Q1x a bond H a bond NH S a bond Q3a OH 1433 CH NEt Q1x a bond H abond NH S a bond Q3b OH 1434 CH NEt Q1x a bond H a bond NH S a bond Q3cOH 1435 CH NEt Q1x a bond H a bond NH O NH Q3a OH 1436 CH NEt Q1x a bondH a bond NH O NH Q3b OH 1437 CH NEt Q1x a bond H a bond NH O NH Q3c OH1438 CH NEt Q1x a bond H a bond NH O a bond Q3a OH 1439 CH NEt Q1x abond H a bond NH O a bond Q3b OH 1440 CH NEt Q1x a bond H a bond NH O abond Q3c OH 1441 CH S Q1o a bond Me a bond NH S NH Q3a OH 1442 CH S Q1oa bond Me a bond NH S NH Q3b OH 1443 CH S Q1o a bond Me a bond NH S NHQ3c OH 1444 CH S Q1o a bond Me a bond NH S a bond Q3a OH 1445 CH S Q1o abond Me a bond NH S a bond Q3b OH 1446 CH S Q1o a bond Me a bond NH S abond Q3c OH 1447 CH S Q1o a bond Me a bond NH O NH Q3a OH 1448 CH S Q1oa bond Me a bond NH O NH Q3b OH 1449 CH S Q1o a bond Me a bond NH O NHQ3c OH 1450 CH S Q1o a bond Me a bond NH O a bond Q3a OH 1451 CH S Q1o abond Me a bond NH O a bond Q3b OH 1452 CH S Q1o a bond Me a bond NH O abond Q3c OH 1453 CH S Q1o a bond H a bond NH S NH Q3a OH 1454 CH S Q1o abond H a bond NH S NH Q3b OH 1455 CH S Q1o a bond H a bond NH S NH Q3cOH 1456 CH S Q1o a bond H a bond NH S a bond Q3a OH 1457 CH S Q1o a bondH a bond NH S a bond Q3b OH 1458 CH S Q1o a bond H a bond NH S a bondQ3c OH 1459 CH S Q1o a bond H a bond NH O NH Q3a OH 1460 CH S Q1o a bondH a bond NH O NH Q3b OH 1461 CH S Q1o a bond H a bond NH O NH Q3c OH1462 CH S Q1o a bond H a bond NH O a bond Q3a OH 1463 CH S Q1o a bond Ha bond NH O a bond Q3b OH 1464 CH S Q1o a bond H a bond NH O a bond Q3cOH 1465 CH S Q1p a bond Me a bond NH S NH Q3a OH 1466 CH S Q1p a bond Mea bond NH S NH Q3b OH 1467 CH S Q1p a bond Me a bond NH S NH Q3c OH 1468CH S Q1p a bond Me a bond NH S a bond Q3a OH 1469 CH S Q1p a bond Me abond NH S a bond Q3b OH 1470 CH S Q1p a bond Me a bond NH S a bond Q3cOH 1471 CH S Q1p a bond Me a bond NH O NH Q3a OH 1472 CH S Q1p a bond Mea bond NH O NH Q3b OH 1473 CH S Q1p a bond Me a bond NH O NH Q3c OH 1474CH S Q1p a bond Me a bond NH O a bond Q3a OH 1475 CH S Q1p a bond Me abond NH O a bond Q3b OH 1476 CH S Q1p a bond Me a bond NH O a bond Q3cOH 1477 CH S Q1p a bond H a bond NH S NH Q3a OH 1478 CH S Q1p a bond H abond NH S NH Q3b OH 1479 CH S Q1p a bond H a bond NH S NH Q3c OH 1480 CHS Q1p a bond H a bond NH S a bond Q3a OH 1481 CH S Q1p a bond H a bondNH S a bond Q3b OH 1482 CH S Q1p a bond H a bond NH S a bond Q3c OH 1483CH S Q1p a bond H a bond NH O NH Q3a OH 1484 CH S Q1p a bond H a bond NHO NH Q3b OH 1485 CH S Q1p a bond H a bond NH O NH Q3c OH 1486 CH S Q1p abond H a bond NH O a bond Q3a OH 1487 CH S Q1p a bond H a bond NH O abond Q3b OH 1488 CH S Q1p a bond H a bond NH O a bond Q3c OH 1489 CH SQ1q a bond Me a bond NH S NH Q3a OH 1490 CH S Q1q a bond Me a bond NH SNH Q3b OH 1491 CH S Q1q a bond Me a bond NH S NH Q3c OH 1492 CH S Q1q abond Me a bond NH S a bond Q3a OH 1493 CH S Q1q a bond Me a bond NH S abond Q3b OH 1494 CH S Q1q a bond Me a bond NH S a bond Q3c OH 1495 CH SQ1q a bond Me a bond NH O NH Q3a OH 1496 CH S Q1q a bond Me a bond NH ONH Q3b OH 1497 CH S Q1q a bond Me a bond NH O NH Q3c OH 1498 CH S Q1q abond Me a bond NH O a bond Q3a OH 1499 CH S Q1q a bond Me a bond NH O abond Q3b OH 1500 CH S Q1q a bond Me a bond NH O a bond Q3c OH 1501 CH SQ1q a bond H a bond NH S NH Q3a OH 1502 CH S Q1q a bond H a bond NH S NHQ3b OH 1503 CH S Q1q a bond H a bond NH S NH Q3c OH 1504 CH S Q1q a bondH a bond NH S a bond Q3a OH 1505 CH S Q1q a bond H a bond NH S a bondQ3b OH 1506 CH S Q1q a bond H a bond NH S a bond Q3c OH 1507 CH S Q1q abond H a bond NH O NH Q3a OH 1508 CH S Q1q a bond H a bond NH O NH Q3bOH 1509 CH S Q1q a bond H a bond NH O NH Q3c OH 1510 CH S Q1q a bond H abond NH O a bond Q3a OH 1511 CH S Q1q a bond H a bond NH O a bond Q3b OH1512 CH S Q1q a bond H a bond NH O a bond Q3c OH 1513 CH S Q1r a bond Mea bond NH S NH Q3a OH 1514 CH S Q1r a bond Me a bond NH S NH Q3b OH 1515CH S Q1r a bond Me a bond NH S NH Q3c OH 1516 CH S Q1r a bond Me a bondNH S a bond Q3a OH 1517 CH S Q1r a bond Me a bond NH S a bond Q3b OH1518 CH S Q1r a bond Me a bond NH S a bond Q3c OH 1519 CH S Q1r a bondMe a bond NH O NH Q3a OH 1520 CH S Q1r a bond Me a bond NH O NH Q3b OH1521 CH S Q1r a bond Me a bond NH O NH Q3c OH 1522 CH S Q1r a bond Me abond NH O a bond Q3a OH 1523 CH S Q1r a bond Me a bond NH O a bond Q3bOH 1524 CH S Q1r a bond Me a bond NH O a bond Q3c OH 1525 CH S Q1r abond H a bond NH S NH Q3a OH 1526 CH S Q1r a bond H a bond NH S NH Q3bOH 1527 CH S Q1r a bond H a bond NH S NH Q3c OH 1528 CH S Q1r a bond H abond NH S a bond Q3a OH 1529 CH S Q1r a bond H a bond NH S a bond Q3b OH1530 CH S Q1r a bond H a bond NH S a bond Q3c OH 1531 CH S Q1r a bond Ha bond NH O NH Q3a OH 1532 CH S Q1r a bond H a bond NH O NH Q3b OH 1533CH S Q1r a bond H a bond NH O NH Q3c OH 1534 CH S Q1r a bond H a bond NHO a bond Q3a OH 1535 CH S Q1r a bond H a bond NH O a bond Q3b OH 1536 CHS Q1r a bond H a bond NH O a bond Q3c OH 1537 CH S Q1s a bond Me a bondNH S NH Q3a OH 1538 CH S Q1s a bond Me a bond NH S NH Q3b OH 1539 CH SQ1s a bond Me a bond NH S NH Q3c OH 1540 CH S Q1s a bond Me a bond NH Sa bond Q3a OH 1541 CH S Q1s a bond Me a bond NH S a bond Q3b OH 1542 CHS Q1s a bond Me a bond NH S a bond Q3c OH 1543 CH S Q1s a bond Me a bondNH O NH Q3a OH 1544 CH S Q1s a bond Me a bond NH O NH Q3b OH 1545 CH SQ1s a bond Me a bond NH O NH Q3c OH 1546 CH S Q1s a bond Me a bond NH Oa bond Q3a OH 1547 CH S Q1s a bond Me a bond NH O a bond Q3b OH 1548 CHS Q1s a bond Me a bond NH O a bond Q3c OH 1549 CH S Q1s a bond H a bondNH S NH Q3a OH 1550 CH S Q1s a bond H a bond NH S NH Q3b OH 1551 CH SQ1s a bond H a bond NH S NH Q3c OH 1552 CH S Q1s a bond H a bond NH S abond Q3a OH 1553 CH S Q1s a bond H a bond NH S a bond Q3b OH 1554 CH SQ1s a bond H a bond NH S a bond Q3c OH 1555 CH S Q1s a bond H a bond NHO NH Q3a OH 1556 CH S Q1s a bond H a bond NH O NH Q3b OH 1557 CH S Q1s abond H a bond NH O NH Q3c OH 1558 CH S Q1s a bond H a bond NH O a bondQ3a OH 1559 CH S Q1s a bond H a bond NH O a bond Q3b OH 1560 CH S Q1s abond H a bond NH O a bond Q3c OH 1561 CH S Q1t a bond Me a bond NH S NHQ3a OH 1562 CH S Q1t a bond Me a bond NH S NH Q3b OH 1563 CH S Q1t abond Me a bond NH S NH Q3c OH 1564 CH S Q1t a bond Me a bond NH S a bondQ3a OH 1565 CH S Q1t a bond Me a bond NH S a bond Q3b OH 1566 CH S Q1t abond Me a bond NH S a bond Q3c OH 1567 CH S Q1t a bond Me a bond NH O NHQ3a OH 1568 CH S Q1t a bond Me a bond NH O NH Q3b OH 1569 CH S Q1t abond Me a bond NH O NH Q3c OH 1570 CH S Q1t a bond Me a bond NH O a bondQ3a OH 1571 CH S Q1t a bond Me a bond NH O a bond Q3b OH 1572 CH S Q1t abond Me a bond NH O a bond Q3c OH 1573 CH S Q1t a bond H a bond NH S NHQ3a OH 1574 CH S Q1t a bond H a bond NH S NH Q3b OH 1575 CH S Q1t a bondH a bond NH S NH Q3c OH 1576 CH S Q1t a bond H a bond NH S a bond Q3a OH1577 CH S Q1t a bond H a bond NH S a bond Q3b OH 1578 CH S Q1t a bond Ha bond NH S a bond Q3c OH 1579 CH S Q1t a bond H a bond NH O NH Q3a OH1580 CH S Q1t a bond H a bond NH O NH Q3b OH 1581 CH S Q1t a bond H abond NH O NH Q3c OH 1582 CH S Q1t a bond H a bond NH O a bond Q3a OH1583 CH S Q1t a bond H a bond NH O a bond Q3b OH 1584 CH S Q1t a bond Ha bond NH O a bond Q3c OH 1585 CH S Q1u a bond Me a bond NH S NH Q3a OH1586 CH S Q1u a bond Me a bond NH S NH Q3b OH 1587 CH S Q1u a bond Me abond NH S NH Q3c OH 1588 CH S Q1u a bond Me a bond NH S a bond Q3a OH1589 CH S Q1u a bond Me a bond NH S a bond Q3b OH 1590 CH S Q1u a bondMe a bond NH S a bond Q3c OH 1591 CH S Q1u a bond Me a bond NH O NH Q3aOH 1592 CH S Q1u a bond Me a bond NH O NH Q3b OH 1593 CH S Q1u a bond Mea bond NH O NH Q3c OH 1594 CH S Q1u a bond Me a bond NH O a bond Q3a OH1595 CH S Q1u a bond Me a bond NH O a bond Q3b OH 1596 CH S Q1u a bondMe a bond NH O a bond Q3c OH 1597 CH S Q1u a bond H a bond NH S NH Q3aOH 1598 CH S Q1u a bond H a bond NH S NH Q3b OH 1599 CH S Q1u a bond H abond NH S NH Q3c OH 1600 CH S Q1u a bond H a bond NH S a bond Q3a OH1601 CH S Q1u a bond H a bond NH S a bond Q3b OH 1602 CH S Q1u a bond Ha bond NH S a bond Q3c OH 1603 CH S Q1u a bond H a bond NH O NH Q3a OH1604 CH S Q1u a bond H a bond NH O NH Q3b OH 1605 CH S Q1u a bond H abond NH O NH Q3c OH 1606 CH S Q1u a bond H a bond NH O a bond Q3a OH1607 CH S Q1u a bond H a bond NH O a bond Q3b OH 1608 CH S Q1u a bond Ha bond NH O a bond Q3c OH 1609 CH S Q1v a bond Me a bond NH S NH Q3a OH1610 CH S Q1v a bond Me a bond NH S NH Q3b OH 1611 CH S Q1v a bond Me abond NH S NH Q3c OH 1612 CH S Q1v a bond Me a bond NH S a bond Q3a OH1613 CH S Q1v a bond Me a bond NH S a bond Q3b OH 1614 CH S Q1v a bondMe a bond NH S a bond Q3c OH 1615 CH S Q1v a bond Me a bond NH O NH Q3aOH 1616 CH S Q1v a bond Me a bond NH O NH Q3b OH 1617 CH S Q1v a bond Mea bond NH O NH Q3c OH 1618 CH S Q1v a bond Me a bond NH O a bond Q3a OH1619 CH S Q1v a bond Me a bond NH O a bond Q3b OH 1620 CH S Q1v a bondMe a bond NH O a bond Q3c OH 1621 CH S Q1v a bond H a bond NH S NH Q3aOH 1622 CH S Q1v a bond H a bond NH S NH Q3b OH 1623 CH S Q1v a bond H abond NH S NH Q3c OH 1624 CH S Q1v a bond H a bond NH S a bond Q3a OH1625 CH S Q1v a bond H a bond NH S a bond Q3b OH 1626 CH S Q1v a bond Ha bond NH S a bond Q3c OH 1627 CH S Q1v a bond H a bond NH O NH Q3a OH1628 CH S Q1v a bond H a bond NH O NH Q3b OH 1629 CH S Q1v a bond H abond NH O NH Q3c OH 1630 CH S Q1v a bond H a bond NH O a bond Q3a OH1631 CH S Q1v a bond H a bond NH O a bond Q3b OH 1632 CH S Q1v a bond Ha bond NH O a bond Q3c OH 1633 CH S Q1w a bond Me a bond NH S NH Q3a OH1634 CH S Q1w a bond Me a bond NH S NH Q3b OH 1635 CH S Q1w a bond Me abond NH S NH Q3c OH 1636 CH S Q1w a bond Me a bond NH S a bond Q3a OH1637 CH S Q1w a bond Me a bond NH S a bond Q3b OH 1638 CH S Q1w a bondMe a bond NH S a bond Q3c OH 1639 CH S Q1w a bond Me a bond NH O NH Q3aOH 1640 CH S Q1w a bond Me a bond NH O NH Q3b OH 1641 CH S Q1w a bond Mea bond NH O NH Q3c OH 1642 CH S Q1w a bond Me a bond NH O a bond Q3a OH1643 CH S Q1w a bond Me a bond NH O a bond Q3b OH 1644 CH S Q1w a bondMe a bond NH O a bond Q3c OH 1645 CH S Q1w a bond H a bond NH S NH Q3aOH 1646 CH S Q1w a bond H a bond NH S NH Q3b OH 1647 CH S Q1w a bond H abond NH S NH Q3c OH 1648 CH S Q1w a bond H a bond NH S a bond Q3a OH1649 CH S Q1w a bond H a bond NH S a bond Q3b OH 1650 CH S Q1w a bond Ha bond NH S a bond Q3c OH 1651 CH S Q1w a bond H a bond NH O NH Q3a OH1652 CH S Q1w a bond H a bond NH O NH Q3b OH 1653 CH S Q1w a bond H abond NH O NH Q3c OH 1654 CH S Q1w a bond H a bond NH O a bond Q3a OH1655 CH S Q1w a bond H a bond NH O a bond Q3b OH 1656 CH S Q1w a bond Ha bond NH O a bond Q3c OH 1657 CH S Q1x a bond Me a bond NH S NH Q3a OH1658 CH S Q1x a bond Me a bond NH S NH Q3b OH 1659 CH S Q1x a bond Me abond NH S NH Q3c OH 1660 CH S Q1x a bond Me a bond NH S a bond Q3a OH1661 CH S Q1x a bond Me a bond NH S a bond Q3b OH 1662 CH S Q1x a bondMe a bond NH S a bond Q3c OH 1663 CH S Q1x a bond Me a bond NH O NH Q3aOH 1664 CH S Q1x a bond Me a bond NH O NH Q3b OH 1665 CH S Q1x a bond Mea bond NH O NH Q3c OH 1666 CH S Q1x a bond Me a bond NH O a bond Q3a OH1667 CH S Q1x a bond Me a bond NH O a bond Q3b OH 1668 CH S Q1x a bondMe a bond NH O a bond Q3c OH 1669 CH S Q1x a bond H a bond NH S NH Q3aOH 1670 CH S Q1x a bond H a bond NH S NH Q3b OH 1671 CH S Q1x a bond H abond NH S NH Q3c OH 1672 CH S Q1x a bond H a bond NH S a bond Q3a OH1673 CH S Q1x a bond H a bond NH S a bond Q3b OH 1674 CH S Q1x a bond Ha bond NH S a bond Q3c OH 1675 CH S Q1x a bond H a bond NH O NH Q3a OH1676 CH S Q1x a bond H a bond NH O NH Q3b OH 1677 CH S Q1x a bond H abond NH O NH Q3c OH 1678 CH S Q1x a bond H a bond NH O a bond Q3a OH1679 CH S Q1x a bond H a bond NH O a bond Q3b OH 1680 CH S Q1x a bond Ha bond NH O a bond Q3c OH 1681 CH O Q1o a bond Me a bond NH S NH Q3a OH1682 CH O Q1o a bond Me a bond NH S NH Q3b OH 1683 CH O Q1o a bond Me abond NH S NH Q3c OH 1684 CH O Q1o a bond Me a bond NH S a bond Q3a OH1685 CH O Q1o a bond Me a bond NH S a bond Q3b OH 1686 CH O Q1o a bondMe a bond NH S a bond Q3c OH 1687 CH O Q1o a bond Me a bond NH O NH Q3aOH 1688 CH O Q1o a bond Me a bond NH O NH Q3b OH 1689 CH O Q1o a bond Mea bond NH O NH Q3c OH 1690 CH O Q1o a bond Me a bond NH O a bond Q3a OH1691 CH O Q1o a bond Me a bond NH O a bond Q3b OH 1692 CH O Q1o a bondMe a bond NH O a bond Q3c OH 1693 CH O Q1o a bond H a bond NH S NH Q3aOH 1694 CH O Q1o a bond H a bond NH S NH Q3b OH 1695 CH O Q1o a bond H abond NH S NH Q3c OH 1696 CH O Q1o a bond H a bond NH S a bond Q3a OH1697 CH O Q1o a bond H a bond NH S a bond Q3b OH 1698 CH O Q1o a bond Ha bond NH S a bond Q3c OH 1699 CH O Q1o a bond H a bond NH O NH Q3a OH1700 CH O Q1o a bond H a bond NH O NH Q3b OH 1701 CH O Q1o a bond H abond NH O NH Q3c OH 1702 CH O Q1o a bond H a bond NH O a bond Q3a OH1703 CH O Q1o a bond H a bond NH O a bond Q3b OH 1704 CH O Q1o a bond Ha bond NH O a bond Q3c OH 1705 CH O Q1p a bond Me a bond NH S NH Q3a OH1706 CH O Q1p a bond Me a bond NH S NH Q3b OH 1707 CH O Q1p a bond Me abond NH S NH Q3c OH 1708 CH O Q1p a bond Me a bond NH S a bond Q3a OH1709 CH O Q1p a bond Me a bond NH S a bond Q3b OH 1710 CH O Q1p a bondMe a bond NH S a bond Q3c OH 1711 CH O Q1p a bond Me a bond NH O NH Q3aOH 1712 CH O Q1p a bond Me a bond NH O NH Q3b OH 1713 CH O Q1p a bond Mea bond NH O NH Q3c OH 1714 CH O Q1p a bond Me a bond NH O a bond Q3a OH1715 CH O Q1p a bond Me a bond NH O a bond Q3b OH 1716 CH O Q1p a bondMe a bond NH O a bond Q3c OH 1717 CH O Q1p a bond H a bond NH S NH Q3aOH 1718 CH O Q1p a bond H a bond NH S NH Q3b OH 1719 CH O Q1p a bond H abond NH S NH Q3c OH 1720 CH O Q1p a bond H a bond NH S a bond Q3a OH1721 CH O Q1p a bond H a bond NH S a bond Q3b OH 1722 CH O Q1p a bond Ha bond NH S a bond Q3c OH 1723 CH O Q1p a bond H a bond NH O NH Q3a OH1724 CH O Q1p a bond H a bond NH O NH Q3b OH 1725 CH O Q1p a bond H abond NH O NH Q3c OH 1726 CH O Q1p a bond H a bond NH O a bond Q3a OH1727 CH O Q1p a bond H a bond NH O a bond Q3b OH 1728 CH O Q1p a bond Ha bond NH O a bond Q3c OH 1729 CH O Q1q a bond Me a bond NH S NH Q3a OH1730 CH O Q1q a bond Me a bond NH S NH Q3b OH 1731 CH O Q1q a bond Me abond NH S NH Q3c OH 1732 CH O Q1q a bond Me a bond NH S a bond Q3a OH1733 CH O Q1q a bond Me a bond NH S a bond Q3b OH 1734 CH O Q1q a bondMe a bond NH S a bond Q3c OH 1735 CH O Q1q a bond Me a bond NH O NH Q3aOH 1736 CH O Q1q a bond Me a bond NH O NH Q3b OH 1737 CH O Q1q a bond Mea bond NH O NH Q3c OH 1738 CH O Q1q a bond Me a bond NH O a bond Q3a OH1739 CH O Q1q a bond Me a bond NH O a bond Q3b OH 1740 CH O Q1q a bondMe a bond NH O a bond Q3c OH 1741 CH O Q1q a bond H a bond NH S NH Q3aOH 1742 CH O Q1q a bond H a bond NH S NH Q3b OH 1743 CH O Q1q a bond H abond NH S NH Q3c OH 1744 CH O Q1q a bond H a bond NH S a bond Q3a OH1745 CH O Q1q a bond H a bond NH S a bond Q3b OH 1746 CH O Q1q a bond Ha bond NH S a bond Q3c OH 1747 CH O Q1q a bond H a bond NH O NH Q3a OH1748 CH O Q1q a bond H a bond NH O NH Q3b OH 1749 CH O Q1q a bond H abond NH O NH Q3c OH 1750 CH O Q1q a bond H a bond NH O a bond Q3a OH1751 CH O Q1q a bond H a bond NH O a bond Q3b OH 1752 CH O Q1q a bond Ha bond NH O a bond Q3c OH 1753 CH O Q1r a bond Me a bond NH S NH Q3a OH1754 CH O Q1r a bond Me a bond NH S NH Q3b OH 1755 CH O Q1r a bond Me abond NH S NH Q3c OH 1756 CH O Q1r a bond Me a bond NH S a bond Q3a OH1757 CH O Q1r a bond Me a bond NH S a bond Q3b OH 1758 CH O Q1r a bondMe a bond NH S a bond Q3c OH 1759 CH O Q1r a bond Me a bond NH O NH Q3aOH 1760 CH O Q1r a bond Me a bond NH O NH Q3b OH 1761 CH O Q1r a bond Mea bond NH O NH Q3c OH 1762 CH O Q1r a bond Me a bond NH O a bond Q3a OH1763 CH O Q1r a bond Me a bond NH O a bond Q3b OH 1764 CH O Q1r a bondMe a bond NH O a bond Q3c OH 1765 CH O Q1r a bond H a bond NH S NH Q3aOH 1766 CH O Q1r a bond H a bond NH S NH Q3b OH 1767 CH O Q1r a bond H abond NH S NH Q3c OH 1768 CH O Q1r a bond H a bond NH S a bond Q3a OH1769 CH O Q1r a bond H a bond NH S a bond Q3b OH 1770 CH O Q1r a bond Ha bond NH S a bond Q3c OH 1771 CH O Q1r a bond H a bond NH O NH Q3a OH1772 CH O Q1r a bond H a bond NH O NH Q3b OH 1773 CH O Q1r a bond H abond NH O NH Q3c OH 1774 CH O Q1r a bond H a bond NH O a bond Q3a OH1775 CH O Q1r a bond H a bond NH O a bond Q3b OH 1776 CH O Q1r a bond Ha bond NH O a bond Q3c OH 1777 CH O Q1s a bond Me a bond NH S NH Q3a OH1778 CH O Q1s a bond Me a bond NH S NH Q3b OH 1779 CH O Q1s a bond Me abond NH S NH Q3c OH 1780 CH O Q1s a bond Me a bond NH S a bond Q3a OH1781 CH O Q1s a bond Me a bond NH S a bond Q3b OH 1782 CH O Q1s a bondMe a bond NH S a bond Q3c OH 1783 CH O Q1s a bond Me a bond NH O NH Q3aOH 1784 CH O Q1s a bond Me a bond NH O NH Q3b OH 1785 CH O Q1s a bond Mea bond NH O NH Q3c OH 1786 CH O Q1s a bond Me a bond NH O a bond Q3a OH1787 CH O Q1s a bond Me a bond NH O a bond Q3b OH 1788 CH O Q1s a bondMe a bond NH O a bond Q3c OH 1789 CH O Q1s a bond H a bond NH S NH Q3aOH 1790 CH O Q1s a bond H a bond NH S NH Q3b OH 1791 CH O Q1s a bond H abond NH S NH Q3c OH 1792 CH O Q1s a bond H a bond NH S a bond Q3a OH1793 CH O Q1s a bond H a bond NH S a bond Q3b OH 1794 CH O Q1s a bond Ha bond NH S a bond Q3c OH 1795 CH O Q1s a bond H a bond NH O NH Q3a OH1796 CH O Q1s a bond H a bond NH O NH Q3b OH 1797 CH O Q1s a bond H abond NH O NH Q3c OH 1798 CH O Q1s a bond H a bond NH O a bond Q3a OH1799 CH O Q1s a bond H a bond NH O a bond Q3b OH 1800 CH O Q1s a bond Ha bond NH O a bond Q3c OH 1801 CH O Q1t a bond Me a bond NH S NH Q3a OH1802 CH O Q1t a bond Me a bond NH S NH Q3b OH 1803 CH O Q1t a bond Me abond NH S NH Q3c OH 1804 CH O Q1t a bond Me a bond NH S a bond Q3a OH1805 CH O Q1t a bond Me a bond NH S a bond Q3b OH 1806 CH O Q1t a bondMe a bond NH S a bond Q3c OH 1807 CH O Q1t a bond Me a bond NH O NH Q3aOH 1808 CH O Q1t a bond Me a bond NH O NH Q3b OH 1809 CH O Q1t a bond Mea bond NH O NH Q3c OH 1810 CH O Q1t a bond Me a bond NH O a bond Q3a OH1811 CH O Q1t a bond Me a bond NH O a bond Q3b OH 1812 CH O Q1t a bondMe a bond NH O a bond Q3c OH 1813 CH O Q1t a bond H a bond NH S NH Q3aOH 1814 CH O Q1t a bond H a bond NH S NH Q3b OH 1815 CH O Q1t a bond H abond NH S NH Q3c OH 1816 CH O Q1t a bond H a bond NH S a bond Q3a OH1817 CH O Q1t a bond H a bond NH S a bond Q3b OH 1818 CH O Q1t a bond Ha bond NH S a bond Q3c OH 1819 CH O Q1t a bond H a bond NH O NH Q3a OH1820 CH O Q1t a bond H a bond NH O NH Q3b OH 1821 CH O Q1t a bond H abond NH O NH Q3c OH 1822 CH O Q1t a bond H a bond NH O a bond Q3a OH1823 CH O Q1t a bond H a bond NH O a bond Q3b OH 1824 CH O Q1t a bond Ha bond NH O a bond Q3c OH 1825 CH O Q1u a bond Me a bond NH S NH Q3a OH1826 CH O Q1u a bond Me a bond NH S NH Q3b OH 1827 CH O Q1u a bond Me abond NH S NH Q3c OH 1828 CH O Q1u a bond Me a bond NH S a bond Q3a OH1829 CH O Q1u a bond Me a bond NH S a bond Q3b OH 1830 CH O Q1u a bondMe a bond NH S a bond Q3c OH 1831 CH O Q1u a bond Me a bond NH O NH Q3aOH 1832 CH O Q1u a bond Me a bond NH O NH Q3b OH 1833 CH O Q1u a bond Mea bond NH O NH Q3c OH 1834 CH O Q1u a bond Me a bond NH O a bond Q3a OH1835 CH O Q1u a bond Me a bond NH O a bond Q3b OH 1836 CH O Q1u a bondMe a bond NH O a bond Q3c OH 1837 CH O Q1u a bond H a bond NH S NH Q3aOH 1838 CH O Q1u a bond H a bond NH S NH Q3b OH 1839 CH O Q1u a bond H abond NH S NH Q3c OH 1840 CH O Q1u a bond H a bond NH S a bond Q3a OH1841 CH O Q1u a bond H a bond NH S a bond Q3b OH 1842 CH O Q1u a bond Ha bond NH S a bond Q3c OH 1843 CH O Q1u a bond H a bond NH O NH Q3a OH1844 CH O Q1u a bond H a bond NH O NH Q3b OH 1845 CH O Q1u a bond H abond NH O NH Q3c OH 1846 CH O Q1u a bond H a bond NH O a bond Q3a OH1847 CH O Q1u a bond H a bond NH O a bond Q3b OH 1848 CH O Q1u a bond Ha bond NH O a bond Q3c OH 1849 CH O Q1v a bond Me a bond NH S NH Q3a OH1850 CH O Q1v a bond Me a bond NH S NH Q3b OH 1851 CH O Q1v a bond Me abond NH S NH Q3c OH 1852 CH O Q1v a bond Me a bond NH S a bond Q3a OH1853 CH O Q1v a bond Me a bond NH S a bond Q3b OH 1854 CH O Q1v a bondMe a bond NH S a bond Q3c OH 1855 CH O Q1v a bond Me a bond NH O NH Q3aOH 1856 CH O Q1v a bond Me a bond NH O NH Q3b OH 1857 CH O Q1v a bond Mea bond NH O NH Q3c OH 1858 CH O Q1v a bond Me a bond NH O a bond Q3a OH1859 CH O Q1v a bond Me a bond NH O a bond Q3b OH 1860 CH O Q1v a bondMe a bond NH O a bond Q3c OH 1861 CH O Q1v a bond H a bond NH S NH Q3aOH 1862 CH O Q1v a bond H a bond NH S NH Q3b OH 1863 CH O Q1v a bond H abond NH S NH Q3c OH 1864 CH O Q1v a bond H a bond NH S a bond Q3a OH1865 CH O Q1v a bond H a bond NH S a bond Q3b OH 1866 CH O Q1v a bond Ha bond NH S a bond Q3c OH 1867 CH O Q1v a bond H a bond NH O NH Q3a OH1868 CH O Q1v a bond H a bond NH O NH Q3b OH 1869 CH O Q1v a bond H abond NH O NH Q3c OH 1870 CH O Q1v a bond H a bond NH O a bond Q3a OH1871 CH O Q1v a bond H a bond NH O a bond Q3b OH 1872 CH O Q1v a bond Ha bond NH O a bond Q3c OH 1873 CH O Q1w a bond Me a bond NH S NH Q3a OH1874 CH O Q1w a bond Me a bond NH S NH Q3b OH 1875 CH O Q1w a bond Me abond NH S NH Q3c OH 1876 CH O Q1w a bond Me a bond NH S a bond Q3a OH1877 CH O Q1w a bond Me a bond NH S a bond Q3b OH 1878 CH O Q1w a bondMe a bond NH S a bond Q3c OH 1879 CH O Q1w a bond Me a bond NH O NH Q3aOH 1880 CH O Q1w a bond Me a bond NH O NH Q3b OH 1881 CH O Q1w a bond Mea bond NH O NH Q3c OH 1882 CH O Q1w a bond Me a bond NH O a bond Q3a OH1883 CH O Q1w a bond Me a bond NH O a bond Q3b OH 1884 CH O Q1w a bondMe a bond NH O a bond Q3c OH 1885 CH O Q1w a bond H a bond NH S NH Q3aOH 1886 CH O Q1w a bond H a bond NH S NH Q3b OH 1887 CH O Q1w a bond H abond NH S NH Q3c OH 1888 CH O Q1w a bond H a bond NH S a bond Q3a OH1889 CH O Q1w a bond H a bond NH S a bond Q3b OH 1890 CH O Q1w a bond Ha bond NH S a bond Q3c OH 1891 CH O Q1w a bond H a bond NH O NH Q3a OH1892 CH O Q1w a bond H a bond NH O NH Q3b OH 1893 CH O Q1w a bond H abond NH O NH Q3c OH 1894 CH O Q1w a bond H a bond NH O a bond Q3a OH1895 CH O Q1w a bond H a bond NH O a bond Q3b OH 1896 CH O Q1w a bond Ha bond NH O a bond Q3c OH 1897 CH O Q1x a bond Me a bond NH S NH Q3a OH1898 CH O Q1x a bond Me a bond NH S NH Q3b OH 1899 CH O Q1x a bond Me abond NH S NH Q3c OH 1900 CH O Q1x a bond Me a bond NH S a bond Q3a OH1901 CH O Q1x a bond Me a bond NH S a bond Q3b OH 1902 CH O Q1x a bondMe a bond NH S a bond Q3c OH 1903 CH O Q1x a bond Me a bond NH O NH Q3aOH 1904 CH O Q1x a bond Me a bond NH O NH Q3b OH 1905 CH O Q1x a bond Mea bond NH O NH Q3c OH 1906 CH O Q1x a bond Me a bond NH O a bond Q3a OH1907 CH O Q1x a bond Me a bond NH O a bond Q3b OH 1908 CH O Q1x a bondMe a bond NH O a bond Q3c OH 1909 CH O Q1x a bond H a bond NH S NH Q3aOH 1910 CH O Q1x a bond H a bond NH S NH Q3b OH 1911 CH O Q1x a bond H abond NH S NH Q3c OH 1912 CH O Q1x a bond H a bond NH S a bond Q3a OH1913 CH O Q1x a bond H a bond NH S a bond Q3b OH 1914 CH O Q1x a bond Ha bond NH S a bond Q3c OH 1915 CH O Q1x a bond H a bond NH O NH Q3a OH1916 CH O Q1x a bond H a bond NH O NH Q3b OH 1917 CH O Q1x a bond H abond NH O NH Q3c OH 1918 CH O Q1x a bond H a bond NH O a bond Q3a OH1919 CH O Q1x a bond H a bond NH O a bond Q3b OH 1920 CH O Q1x a bond Ha bond NH O a bond Q3c OH 1921 CMe NMe Q1o a bond Me a bond NH S NH Q3aOH 1922 CMe NMe Q1o a bond Me a bond NH S NH Q3b OH 1923 CMe NMe Q1o abond Me a bond NH S NH Q3c OH 1924 CMe NMe Q1o a bond Me a bond NH S abond Q3a OH 1925 CMe NMe Q1o a bond Me a bond NH S a bond Q3b OH 1926CMe NMe Q1o a bond Me a bond NH S a bond Q3c OH 1927 CMe NMe Q1o a bondMe a bond NH O NH Q3a OH 1928 CMe NMe Q1o a bond Me a bond NH O NH Q3bOH 1929 CMe NMe Q1o a bond Me a bond NH O NH Q3c OH 1930 CMe NMe Q1o abond Me a bond NH O a bond Q3a OH 1931 CMe NMe Q1o a bond Me a bond NH Oa bond Q3b OH 1932 CMe NMe Q1o a bond Me a bond NH O a bond Q3c OH 1933CMe NMe Q1o a bond H a bond NH S NH Q3a OH 1934 CMe NMe Q1o a bond H abond NH S NH Q3b OH 1935 CMe NMe Q1o a bond H a bond NH S NH Q3c OH 1936CMe NMe Q1o a bond H a bond NH S a bond Q3a OH 1937 CMe NMe Q1o a bond Ha bond NH S a bond Q3b OH 1938 CMe NMe Q1o a bond H a bond NH S a bondQ3c OH 1939 CMe NMe Q1o a bond H a bond NH O NH Q3a OH 1940 CMe NMe Q1oa bond H a bond NH O NH Q3b OH 1941 CMe NMe Q1o a bond H a bond NH O NHQ3c OH 1942 CMe NMe Q1o a bond H a bond NH O a bond Q3a OH 1943 CMe NMeQ1o a bond H a bond NH O a bond Q3b OH 1944 CMe NMe Q1o a bond H a bondNH O a bond Q3c OH 1945 CMe NMe Q1p a bond Me a bond NH S NH Q3a OH 1946CMe NMe Q1p a bond Me a bond NH S NH Q3b OH 1947 CMe NMe Q1p a bond Me abond NH S NH Q3c OH 1948 CMe NMe Q1p a bond Me a bond NH S a bond Q3a OH1949 CMe NMe Q1p a bond Me a bond NH S a bond Q3b OH 1950 CMe NMe Q1p abond Me a bond NH S a bond Q3c OH 1951 CMe NMe Q1p a bond Me a bond NH ONH Q3a OH 1952 CMe NMe Q1p a bond Me a bond NH O NH Q3b OH 1953 CMe NMeQ1p a bond Me a bond NH O NH Q3c OH 1954 CMe NMe Q1p a bond Me a bond NHO a bond Q3a OH 1955 CMe NMe Q1p a bond Me a bond NH O a bond Q3b OH1956 CMe NMe Q1p a bond Me a bond NH O a bond Q3c OH 1957 CMe NMe Q1p abond H a bond NH S NH Q3a OH 1958 CMe NMe Q1p a bond H a bond NH S NHQ3b OH 1959 CMe NMe Q1p a bond H a bond NH S NH Q3c OH 1960 CMe NMe Q1pa bond H a bond NH S a bond Q3a OH 1961 CMe NMe Q1p a bond H a bond NH Sa bond Q3b OH 1962 CMe NMe Q1p a bond H a bond NH S a bond Q3c OH 1963CMe NMe Q1p a bond H a bond NH O NH Q3a OH 1964 CMe NMe Q1p a bond H abond NH O NH Q3b OH 1965 CMe NMe Q1p a bond H a bond NH O NH Q3c OH 1966CMe NMe Q1p a bond H a bond NH O a bond Q3a OH 1967 CMe NMe Q1p a bond Ha bond NH O a bond Q3b OH 1968 CMe NMe Q1p a bond H a bond NH O a bondQ3c OH 1969 CMe NMe Q1q a bond Me a bond NH S NH Q3a OH 1970 CMe NMe Q1qa bond Me a bond NH S NH Q3b OH 1971 CMe NMe Q1q a bond Me a bond NH SNH Q3c OH 1972 CMe NMe Q1q a bond Me a bond NH S a bond Q3a OH 1973 CMeNMe Q1q a bond Me a bond NH S a bond Q3b OH 1974 CMe NMe Q1q a bond Me abond NH S a bond Q3c OH 1975 CMe NMe Q1q a bond Me a bond NH O NH Q3a OH1976 CMe NMe Q1q a bond Me a bond NH O NH Q3b OH 1977 CMe NMe Q1q a bondMe a bond NH O NH Q3c OH 1978 CMe NMe Q1q a bond Me a bond NH O a bondQ3a OH 1979 CMe NMe Q1q a bond Me a bond NH O a bond Q3b OH 1980 CMe NMeQ1q a bond Me a bond NH O a bond Q3c OH 1981 CMe NMe Q1q a bond H a bondNH S NH Q3a OH 1982 CMe NMe Q1q a bond H a bond NH S NH Q3b OH 1983 CMeNMe Q1q a bond H a bond NH S NH Q3c OH 1984 CMe NMe Q1q a bond H a bondNH S a bond Q3a OH 1985 CMe NMe Q1q a bond H a bond NH S a bond Q3b OH1986 CMe NMe Q1q a bond H a bond NH S a bond Q3c OH 1987 CMe NMe Q1q abond H a bond NH O NH Q3a OH 1988 CMe NMe Q1q a bond H a bond NH O NHQ3b OH 1989 CMe NMe Q1q a bond H a bond NH O NH Q3c OH 1990 CMe NMe Q1qa bond H a bond NH O a bond Q3a OH 1991 CMe NMe Q1q a bond H a bond NH Oa bond Q3b OH 1992 CMe NMe Q1q a bond H a bond NH O a bond Q3c OH 1993CMe NMe Q1r a bond Me a bond NH S NH Q3a OH 1994 CMe NMe Q1r a bond Me abond NH S NH Q3b OH 1995 CMe NMe Q1r a bond Me a bond NH S NH Q3c OH1996 CMe NMe Q1r a bond Me a bond NH S a bond Q3a OH 1997 CMe NMe Q1r abond Me a bond NH S a bond Q3b OH 1998 CMe NMe Q1r a bond Me a bond NH Sa bond Q3c OH 1999 CMe NMe Q1r a bond Me a bond NH O NH Q3a OH 2000 CMeNMe Q1r a bond Me a bond NH O NH Q3b OH 2001 CMe NMe Q1r a bond Me abond NH O NH Q3c OH 2002 CMe NMe Q1r a bond Me a bond NH O a bond Q3a OH2003 CMe NMe Q1r a bond Me a bond NH O a bond Q3b OH 2004 CMe NMe Q1r abond Me a bond NH O a bond Q3c OH 2005 CMe NMe Q1r a bond H a bond NH SNH Q3a OH 2006 CMe NMe Q1r a bond H a bond NH S NH Q3b OH 2007 CMe NMeQ1r a bond H a bond NH S NH Q3c OH 2008 CMe NMe Q1r a bond H a bond NH Sa bond Q3a OH 2009 CMe NMe Q1r a bond H a bond NH S a bond Q3b OH 2010CMe NMe Q1r a bond H a bond NH S a bond Q3c OH 2011 CMe NMe Q1r a bond Ha bond NH O NH Q3a OH 2012 CMe NMe Q1r a bond H a bond NH O NH Q3b OH2013 CMe NMe Q1r a bond H a bond NH O NH Q3c OH 2014 CMe NMe Q1r a bondH a bond NH O a bond Q3a OH 2015 CMe NMe Q1r a bond H a bond NH O a bondQ3b OH 2016 CMe NMe Q1r a bond H a bond NH O a bond Q3c OH 2017 CMe NMeQ1s a bond Me a bond NH S NH Q3a OH 2018 CMe NMe Q1s a bond Me a bond NHS NH Q3b OH 2019 CMe NMe Q1s a bond Me a bond NH S NH Q3c OH 2020 CMeNMe Q1s a bond Me a bond NH S a bond Q3a OH 2021 CMe NMe Q1s a bond Me abond NH S a bond Q3b OH 2022 CMe NMe Q1s a bond Me a bond NH S a bondQ3c OH 2023 CMe NMe Q1s a bond Me a bond NH O NH Q3a OH 2024 CMe NMe Q1sa bond Me a bond NH O NH Q3b OH 2025 CMe NMe Q1s a bond Me a bond NH ONH Q3c OH 2026 CMe NMe Q1s a bond Me a bond NH O a bond Q3a OH 2027 CMeNMe Q1s a bond Me a bond NH O a bond Q3b OH 2028 CMe NMe Q1s a bond Me abond NH O a bond Q3c OH 2029 CMe NMe Q1s a bond H a bond NH S NH Q3a OH2030 CMe NMe Q1s a bond H a bond NH S NH Q3b OH 2031 CMe NMe Q1s a bondH a bond NH S NH Q3c OH 2032 CMe NMe Q1s a bond H a bond NH S a bond Q3aOH 2033 CMe NMe Q1s a bond H a bond NH S a bond Q3b OH 2034 CMe NMe Q1sa bond H a bond NH S a bond Q3c OH 2035 CMe NMe Q1s a bond H a bond NH ONH Q3a OH 2036 CMe NMe Q1s a bond H a bond NH O NH Q3b OH 2037 CMe NMeQ1s a bond H a bond NH O NH Q3c OH 2038 CMe NMe Q1s a bond H a bond NH Oa bond Q3a OH 2039 CMe NMe Q1s a bond H a bond NH O a bond Q3b OH 2040CMe NMe Q1s a bond H a bond NH O a bond Q3c OH 2041 CMe NMe Q1t a bondMe a bond NH S NH Q3a OH 2042 CMe NMe Q1t a bond Me a bond NH S NH Q3bOH 2043 CMe NMe Q1t a bond Me a bond NH S NH Q3c OH 2044 CMe NMe Q1t abond Me a bond NH S a bond Q3a OH 2045 CMe NMe Q1t a bond Me a bond NH Sa bond Q3b OH 2046 CMe NMe Q1t a bond Me a bond NH S a bond Q3c OH 2047CMe NMe Q1t a bond Me a bond NH O NH Q3a OH 2048 CMe NMe Q1t a bond Me abond NH O NH Q3b OH 2049 CMe NMe Q1t a bond Me a bond NH O NH Q3c OH2050 CMe NMe Q1t a bond Me a bond NH O a bond Q3a OH 2051 CMe NMe Q1t abond Me a bond NH O a bond Q3b OH 2052 CMe NMe Q1t a bond Me a bond NH Oa bond Q3c OH 2053 CMe NMe Q1t a bond H a bond NH S NH Q3a OH 2054 CMeNMe Q1t a bond H a bond NH S NH Q3b OH 2055 CMe NMe Q1t a bond H a bondNH S NH Q3c OH 2056 CMe NMe Q1t a bond H a bond NH S a bond Q3a OH 2057CMe NMe Q1t a bond H a bond NH S a bond Q3b OH 2058 CMe NMe Q1t a bond Ha bond NH S a bond Q3c OH 2059 CMe NMe Q1t a bond H a bond NH O NH Q3aOH 2060 CMe NMe Q1t a bond H a bond NH O NH Q3b OH 2061 CMe NMe Q1t abond H a bond NH O NH Q3c OH 2062 CMe NMe Q1t a bond H a bond NH O abond Q3a OH 2063 CMe NMe Q1t a bond H a bond NH O a bond Q3b OH 2064 CMeNMe Q1t a bond H a bond NH O a bond Q3c OH 2065 CMe NMe Q1u a bond Me abond NH S NH Q3a OH 2066 CMe NMe Q1u a bond Me a bond NH S NH Q3b OH2067 CMe NMe Q1u a bond Me a bond NH S NH Q3c OH 2068 CMe NMe Q1u a bondMe a bond NH S a bond Q3a OH 2069 CMe NMe Q1u a bond Me a bond NH S abond Q3b OH 2070 CMe NMe Q1u a bond Me a bond NH S a bond Q3c OH 2071CMe NMe Q1u a bond Me a bond NH O NH Q3a OH 2072 CMe NMe Q1u a bond Me abond NH O NH Q3b OH 2073 CMe NMe Q1u a bond Me a bond NH O NH Q3c OH2074 CMe NMe Q1u a bond Me a bond NH O a bond Q3a OH 2075 CMe NMe Q1u abond Me a bond NH O a bond Q3b OH 2076 CMe NMe Q1u a bond Me a bond NH Oa bond Q3c OH 2077 CMe NMe Q1u a bond H a bond NH S NH Q3a OH 2078 CMeNMe Q1u a bond H a bond NH S NH Q3b OH 2079 CMe NMe Q1u a bond H a bondNH S NH Q3c OH 2080 CMe NMe Q1u a bond H a bond NH S a bond Q3a OH 2081CMe NMe Q1u a bond H a bond NH S a bond Q3b OH 2082 CMe NMe Q1u a bond Ha bond NH S a bond Q3c OH 2083 CMe NMe Q1u a bond H a bond NH O NH Q3aOH 2084 CMe NMe Q1u a bond H a bond NH O NH Q3b OH 2085 CMe NMe Q1u abond H a bond NH O NH Q3c OH 2086 CMe NMe Q1u a bond H a bond NH O abond Q3a OH 2087 CMe NMe Q1u a bond H a bond NH O a bond Q3b OH 2088 CMeNMe Q1u a bond H a bond NH O a bond Q3c OH 2089 CMe NMe Q1v a bond Me abond NH S NH Q3a OH 2090 CMe NMe Q1v a bond Me a bond NH S NH Q3b OH2091 CMe NMe Q1v a bond Me a bond NH S NH Q3c OH 2092 CMe NMe Q1v a bondMe a bond NH S a bond Q3a OH 2093 CMe NMe Q1v a bond Me a bond NH S abond Q3b OH 2094 CMe NMe Q1v a bond Me a bond NH S a bond Q3c OH 2095CMe NMe Q1v a bond Me a bond NH O NH Q3a OH 2096 CMe NMe Q1v a bond Me abond NH O NH Q3b OH 2097 CMe NMe Q1v a bond Me a bond NH O NH Q3c OH2098 CMe NMe Q1v a bond Me a bond NH O a bond Q3a OH 2099 CMe NMe Q1v abond Me a bond NH O a bond Q3b OH 2100 CMe NMe Q1v a bond Me a bond NH Oa bond Q3c OH 2101 CMe NMe Q1v a bond H a bond NH S NH Q3a OH 2102 CMeNMe Q1v a bond H a bond NH S NH Q3b OH 2103 CMe NMe Q1v a bond H a bondNH S NH Q3c OH 2104 CMe NMe Q1v a bond H a bond NH S a bond Q3a OH 2105CMe NMe Q1v a bond H a bond NH S a bond Q3b OH 2106 CMe NMe Q1v a bond Ha bond NH S a bond Q3c OH 2107 CMe NMe Q1v a bond H a bond NH O NH Q3aOH 2108 CMe NMe Q1v a bond H a bond NH O NH Q3b OH 2109 CMe NMe Q1v abond H a bond NH O NH Q3c OH 2110 CMe NMe Q1v a bond H a bond NH O abond Q3a OH 2111 CMe NMe Q1v a bond H a bond NH O a bond Q3b OH 2112 CMeNMe Q1v a bond H a bond NH O a bond Q3c OH 2113 CMe NMe Q1w a bond Me abond NH S NH Q3a OH 2114 CMe NMe Q1w a bond Me a bond NH S NH Q3b OH2115 CMe NMe Q1w a bond Me a bond NH S NH Q3c OH 2116 CMe NMe Q1w a bondMe a bond NH S a bond Q3a OH 2117 CMe NMe Q1w a bond Me a bond NH S abond Q3b OH 2118 CMe NMe Q1w a bond Me a bond NH S a bond Q3c OH 2119CMe NMe Q1w a bond Me a bond NH O NH Q3a OH 2120 CMe NMe Q1w a bond Me abond NH O NH Q3b OH 2121 CMe NMe Q1w a bond Me a bond NH O NH Q3c OH2122 CMe NMe Q1w a bond Me a bond NH O a bond Q3a OH 2123 CMe NMe Q1w abond Me a bond NH O a bond Q3b OH 2124 CMe NMe Q1w a bond Me a bond NH Oa bond Q3c OH 2125 CMe NMe Q1w a bond H a bond NH S NH Q3a OH 2126 CMeNMe Q1w a bond H a bond NH S NH Q3b OH 2127 CMe NMe Q1w a bond H a bondNH S NH Q3c OH 2128 CMe NMe Q1w a bond H a bond NH S a bond Q3a OH 2129CMe NMe Q1w a bond H a bond NH S a bond Q3b OH 2130 CMe NMe Q1w a bond Ha bond NH S a bond Q3c OH 2131 CMe NMe Q1w a bond H a bond NH O NH Q3aOH 2132 CMe NMe Q1w a bond H a bond NH O NH Q3b OH 2133 CMe NMe Q1w abond H a bond NH O NH Q3c OH 2134 CMe NMe Q1w a bond H a bond NH O abond Q3a OH 2135 CMe NMe Q1w a bond H a bond NH O a bond Q3b OH 2136 CMeNMe Q1w a bond H a bond NH O a bond Q3c OH 2137 CMe NMe Q1x a bond Me abond NH S NH Q3a OH 2138 CMe NMe Q1x a bond Me a bond NH S NH Q3b OH2139 CMe NMe Q1x a bond Me a bond NH S NH Q3c OH 2140 CMe NMe Q1x a bondMe a bond NH S a bond Q3a OH 2141 CMe NMe Q1x a bond Me a bond NH S abond Q3b OH 2142 CMe NMe Q1x a bond Me a bond NH S a bond Q3c OH 2143CMe NMe Q1x a bond Me a bond NH O NH Q3a OH 2144 CMe NMe Q1x a bond Me abond NH O NH Q3b OH 2145 CMe NMe Q1x a bond Me a bond NH O NH Q3c OH2146 CMe NMe Q1x a bond Me a bond NH O a bond Q3a OH 2147 CMe NMe Q1x abond Me a bond NH O a bond Q3b OH 2148 CMe NMe Q1x a bond Me a bond NH Oa bond Q3c OH 2149 CMe NMe Q1x a bond H a bond NH S NH Q3a OH 2150 CMeNMe Q1x a bond H a bond NH S NH Q3b OH 2151 CMe NMe Q1x a bond H a bondNH S NH Q3c OH 2152 CMe NMe Q1x a bond H a bond NH S a bond Q3a OH 2153CMe NMe Q1x a bond H a bond NH S a bond Q3b OH 2154 CMe NMe Q1x a bond Ha bond NH S a bond Q3c OH 2155 CMe NMe Q1x a bond H a bond NH O NH Q3aOH 2156 CMe NMe Q1x a bond H a bond NH O NH Q3b OH 2157 CMe NMe Q1x abond H a bond NH O NH Q3c OH 2158 CMe NMe Q1x a bond H a bond NH O abond Q3a OH 2159 CMe NMe Q1x a bond H a bond NH O a bond Q3b OH 2160 CMeNMe Q1x a bond H a bond NH O a bond Q3c OH 2161 CMe NEt Q1o a bond Me abond NH S NH Q3a OH 2162 CMe NEt Q1o a bond Me a bond NH S NH Q3b OH2163 CMe NEt Q1o a bond Me a bond NH S NH Q3c OH 2164 CMe NEt Q1o a bondMe a bond NH S a bond Q3a OH 2165 CMe NEt Q1o a bond Me a bond NH S abond Q3b OH 2166 CMe NEt Q1o a bond Me a bond NH S a bond Q3c OH 2167CMe NEt Q1o a bond Me a bond NH O NH Q3a OH 2168 CMe NEt Q1o a bond Me abond NH O NH Q3b OH 2169 CMe NEt Q1o a bond Me a bond NH O NH Q3c OH2170 CMe NEt Q1o a bond Me a bond NH O a bond Q3a OH 2171 CMe NEt Q1o abond Me a bond NH O a bond Q3b OH 2172 CMe NEt Q1o a bond Me a bond NH Oa bond Q3c OH 2173 CMe NEt Q1o a bond H a bond NH S NH Q3a OH 2174 CMeNEt Q1o a bond H a bond NH S NH Q3b OH 2175 CMe NEt Q1o a bond H a bondNH S NH Q3c OH 2176 CMe NEt Q1o a bond H a bond NH S a bond Q3a OH 2177CMe NEt Q1o a bond H a bond NH S a bond Q3b OH 2178 CMe NEt Q1o a bond Ha bond NH S a bond Q3c OH 2179 CMe NEt Q1o a bond H a bond NH O NH Q3aOH 2180 CMe NEt Q1o a bond H a bond NH O NH Q3b OH 2181 CMe NEt Q1o abond H a bond NH O NH Q3c OH 2182 CMe NEt Q1o a bond H a bond NH O abond Q3a OH 2183 CMe NEt Q1o a bond H a bond NH O a bond Q3b OH 2184 CMeNEt Q1o a bond H a bond NH O a bond Q3c OH 2185 CMe NEt Q1p a bond Me abond NH S NH Q3a OH 2186 CMe NEt Q1p a bond Me a bond NH S NH Q3b OH2187 CMe NEt Q1p a bond Me a bond NH S NH Q3c OH 2188 CMe NEt Q1p a bondMe a bond NH S a bond Q3a OH 2189 CMe NEt Q1p a bond Me a bond NH S abond Q3b OH 2190 CMe NEt Q1p a bond Me a bond NH S a bond Q3c OH 2191CMe NEt Q1p a bond Me a bond NH O NH Q3a OH 2192 CMe NEt Q1p a bond Me abond NH O NH Q3b OH 2193 CMe NEt Q1p a bond Me a bond NH O NH Q3c OH2194 CMe NEt Q1p a bond Me a bond NH O a bond Q3a OH 2195 CMe NEt Q1p abond Me a bond NH O a bond Q3b OH 2196 CMe NEt Q1p a bond Me a bond NH Oa bond Q3c OH 2197 CMe NEt Q1p a bond H a bond NH S NH Q3a OH 2198 CMeNEt Q1p a bond H a bond NH S NH Q3b OH 2199 CMe NEt Q1p a bond H a bondNH S NH Q3c OH 2200 CMe NEt Q1p a bond H a bond NH S a bond Q3a OH 2201CMe NEt Q1p a bond H a bond NH S a bond Q3b OH 2202 CMe NEt Q1p a bond Ha bond NH S a bond Q3c OH 2203 CMe NEt Q1p a bond H a bond NH O NH Q3aOH 2204 CMe NEt Q1p a bond H a bond NH O NH Q3b OH 2205 CMe NEt Q1p abond H a bond NH O NH Q3c OH 2206 CMe NEt Q1p a bond H a bond NH O abond Q3a OH 2207 CMe NEt Q1p a bond H a bond NH O a bond Q3b OH 2208 CMeNEt Q1p a bond H a bond NH O a bond Q3c OH 2209 CMe NEt Q1q a bond Me abond NH S NH Q3a OH 2210 CMe NEt Q1q a bond Me a bond NH S NH Q3b OH2211 CMe NEt Q1q a bond Me a bond NH S NH Q3c OH 2212 CMe NEt Q1q a bondMe a bond NH S a bond Q3a OH 2213 CMe NEt Q1q a bond Me a bond NH S abond Q3b OH 2214 CMe NEt Q1q a bond Me a bond NH S a bond Q3c OH 2215CMe NEt Q1q a bond Me a bond NH O NH Q3a OH 2216 CMe NEt Q1q a bond Me abond NH O NH Q3b OH 2217 CMe NEt Q1q a bond Me a bond NH O NH Q3c OH2218 CMe NEt Q1q a bond Me a bond NH O a bond Q3a OH 2219 CMe NEt Q1q abond Me a bond NH O a bond Q3b OH 2220 CMe NEt Q1q a bond Me a bond NH Oa bond Q3c OH 2221 CMe NEt Q1q a bond H a bond NH S NH Q3a OH 2222 CMeNEt Q1q a bond H a bond NH S NH Q3b OH 2223 CMe NEt Q1q a bond H a bondNH S NH Q3c OH 2224 CMe NEt Q1q a bond H a bond NH S a bond Q3a OH 2225CMe NEt Q1q a bond H a bond NH S a bond Q3b OH 2226 CMe NEt Q1q a bond Ha bond NH S a bond Q3c OH 2227 CMe NEt Q1q a bond H a bond NH O NH Q3aOH 2228 CMe NEt Q1q a bond H a bond NH O NH Q3b OH 2229 CMe NEt Q1q abond H a bond NH O NH Q3c OH 2230 CMe NEt Q1q a bond H a bond NH O abond Q3a OH 2231 CMe NEt Q1q a bond H a bond NH O a bond Q3b OH 2232 CMeNEt Q1q a bond H a bond NH O a bond Q3c OH 2233 CMe NEt Q1r a bond Me abond NH S NH Q3a OH 2234 CMe NEt Q1r a bond Me a bond NH S NH Q3b OH2235 CMe NEt Q1r a bond Me a bond NH S NH Q3c OH 2236 CMe NEt Q1r a bondMe a bond NH S a bond Q3a OH 2237 CMe NEt Q1r a bond Me a bond NH S abond Q3b OH 2238 CMe NEt Q1r a bond Me a bond NH S a bond Q3c OH 2239CMe NEt Q1r a bond Me a bond NH O NH Q3a OH 2240 CMe NEt Q1r a bond Me abond NH O NH Q3b OH 2241 CMe NEt Q1r a bond Me a bond NH O NH Q3c OH2242 CMe NEt Q1r a bond Me a bond NH O a bond Q3a OH 2243 CMe NEt Q1r abond Me a bond NH O a bond Q3b OH 2244 CMe NEt Q1r a bond Me a bond NH Oa bond Q3c OH 2245 CMe NEt Q1r a bond H a bond NH S NH Q3a OH 2246 CMeNEt Q1r a bond H a bond NH S NH Q3b OH 2247 CMe NEt Q1r a bond H a bondNH S NH Q3c OH 2248 CMe NEt Q1r a bond H a bond NH S a bond Q3a OH 2249CMe NEt Q1r a bond H a bond NH S a bond Q3b OH 2250 CMe NEt Q1r a bond Ha bond NH S a bond Q3c OH 2251 CMe NEt Q1r a bond H a bond NH O NH Q3aOH 2252 CMe NEt Q1r a bond H a bond NH O NH Q3b OH 2253 CMe NEt Q1r abond H a bond NH O NH Q3c OH 2254 CMe NEt Q1r a bond H a bond NH O abond Q3a OH 2255 CMe NEt Q1r a bond H a bond NH O a bond Q3b OH 2256 CMeNEt Q1r a bond H a bond NH O a bond Q3c OH 2257 CMe NEt Q1s a bond Me abond NH S NH Q3a OH 2258 CMe NEt Q1s a bond Me a bond NH S NH Q3b OH2259 CMe NEt Q1s a bond Me a bond NH S NH Q3c OH 2260 CMe NEt Q1s a bondMe a bond NH S a bond Q3a OH 2261 CMe NEt Q1s a bond Me a bond NH S abond Q3b OH 2262 CMe NEt Q1s a bond Me a bond NH S a bond Q3c OH 2263CMe NEt Q1s a bond Me a bond NH O NH Q3a OH 2264 CMe NEt Q1s a bond Me abond NH O NH Q3b OH 2265 CMe NEt Q1s a bond Me a bond NH O NH Q3c OH2266 CMe NEt Q1s a bond Me a bond NH O a bond Q3a OH 2267 CMe NEt Q1s abond Me a bond NH O a bond Q3b OH 2268 CMe NEt Q1s a bond Me a bond NH Oa bond Q3c OH 2269 CMe NEt Q1s a bond H a bond NH S NH Q3a OH 2270 CMeNEt Q1s a bond H a bond NH S NH Q3b OH 2271 CMe NEt Q1s a bond H a bondNH S NH Q3c OH 2272 CMe NEt Q1s a bond H a bond NH S a bond Q3a OH 2273CMe NEt Q1s a bond H a bond NH S a bond Q3b OH 2274 CMe NEt Q1s a bond Ha bond NH S a bond Q3c OH 2275 CMe NEt Q1s a bond H a bond NH O NH Q3aOH 2276 CMe NEt Q1s a bond H a bond NH O NH Q3b OH 2277 CMe NEt Q1s abond H a bond NH O NH Q3c OH 2278 CMe NEt Q1s a bond H a bond NH O abond Q3a OH 2279 CMe NEt Q1s a bond H a bond NH O a bond Q3b OH 2280 CMeNEt Q1s a bond H a bond NH O a bond Q3c OH 2281 CMe NEt Q1t a bond Me abond NH S NH Q3a OH 2282 CMe NEt Q1t a bond Me a bond NH S NH Q3b OH2283 CMe NEt Q1t a bond Me a bond NH S NH Q3c OH 2284 CMe NEt Q1t a bondMe a bond NH S a bond Q3a OH 2285 CMe NEt Q1t a bond Me a bond NH S abond Q3b OH 2286 CMe NEt Q1t a bond Me a bond NH S a bond Q3c OH 2287CMe NEt Q1t a bond Me a bond NH O NH Q3a OH 2288 CMe NEt Q1t a bond Me abond NH O NH Q3b OH 2289 CMe NEt Q1t a bond Me a bond NH O NH Q3c OH2290 CMe NEt Q1t a bond Me a bond NH O a bond Q3a OH 2291 CMe NEt Q1t abond Me a bond NH O a bond Q3b OH 2292 CMe NEt Q1t a bond Me a bond NH Oa bond Q3c OH 2293 CMe NEt Q1t a bond H a bond NH S NH Q3a OH 2294 CMeNEt Q1t a bond H a bond NH S NH Q3b OH 2295 CMe NEt Q1t a bond H a bondNH S NH Q3c OH 2296 CMe NEt Q1t a bond H a bond NH S a bond Q3a OH 2297CMe NEt Q1t a bond H a bond NH S a bond Q3b OH 2298 CMe NEt Q1t a bond Ha bond NH S a bond Q3c OH 2299 CMe NEt Q1t a bond H a bond NH O NH Q3aOH 2300 CMe NEt Q1t a bond H a bond NH O NH Q3b OH 2301 CMe NEt Q1t abond H a bond NH O NH Q3c OH 2302 CMe NEt Q1t a bond H a bond NH O abond Q3a OH 2303 CMe NEt Q1t a bond H a bond NH O a bond Q3b OH 2304 CMeNEt Q1t a bond H a bond NH O a bond Q3c OH 2305 CMe NEt Q1u a bond Me abond NH S NH Q3a OH 2306 CMe NEt Q1u a bond Me a bond NH S NH Q3b OH2307 CMe NEt Q1u a bond Me a bond NH S NH Q3c OH 2308 CMe NEt Q1u a bondMe a bond NH S a bond Q3a OH 2309 CMe NEt Q1u a bond Me a bond NH S abond Q3b OH 2310 CMe NEt Q1u a bond Me a bond NH S a bond Q3c OH 2311CMe NEt Q1u a bond Me a bond NH O NH Q3a OH 2312 CMe NEt Q1u a bond Me abond NH O NH Q3b OH 2313 CMe NEt Q1u a bond Me a bond NH O NH Q3c OH2314 CMe NEt Q1u a bond Me a bond NH O a bond Q3a OH 2315 CMe NEt Q1u abond Me a bond NH O a bond Q3b OH 2316 CMe NEt Q1u a bond Me a bond NH Oa bond Q3c OH 2317 CMe NEt Q1u a bond H a bond NH S NH Q3a OH 2318 CMeNEt Q1u a bond H a bond NH S NH Q3b OH 2319 CMe NEt Q1u a bond H a bondNH S NH Q3c OH 2320 CMe NEt Q1u a bond H a bond NH S a bond Q3a OH 2321CMe NEt Q1u a bond H a bond NH S a bond Q3b OH 2322 CMe NEt Q1u a bond Ha bond NH S a bond Q3c OH 2323 CMe NEt Q1u a bond H a bond NH O NH Q3aOH 2324 CMe NEt Q1u a bond H a bond NH O NH Q3b OH 2325 CMe NEt Q1u abond H a bond NH O NH Q3c OH 2326 CMe NEt Q1u a bond H a bond NH O abond Q3a OH 2327 CMe NEt Q1u a bond H a bond NH O a bond Q3b OH 2328 CMeNEt Q1u a bond H a bond NH O a bond Q3c OH 2329 CMe NEt Q1v a bond Me abond NH S NH Q3a OH 2330 CMe NEt Q1v a bond Me a bond NH S NH Q3b OH2331 CMe NEt Q1v a bond Me a bond NH S NH Q3c OH 2332 CMe NEt Q1v a bondMe a bond NH S a bond Q3a OH 2333 CMe NEt Q1v a bond Me a bond NH S abond Q3b OH 2334 CMe NEt Q1v a bond Me a bond NH S a bond Q3c OH 2335CMe NEt Q1v a bond Me a bond NH O NH Q3a OH 2336 CMe NEt Q1v a bond Me abond NH O NH Q3b OH 2337 CMe NEt Q1v a bond Me a bond NH O NH Q3c OH2338 CMe NEt Q1v a bond Me a bond NH O a bond Q3a OH 2339 CMe NEt Q1v abond Me a bond NH O a bond Q3b OH 2340 CMe NEt Q1v a bond Me a bond NH Oa bond Q3c OH 2341 CMe NEt Q1v a bond H a bond NH S NH Q3a OH 2342 CMeNEt Q1v a bond H a bond NH S NH Q3b OH 2343 CMe NEt Q1v a bond H a bondNH S NH Q3c OH 2344 CMe NEt Q1v a bond H a bond NH S a bond Q3a OH 2345CMe NEt Q1v a bond H a bond NH S a bond Q3b OH 2346 CMe NEt Q1v a bond Ha bond NH S a bond Q3c OH 2347 CMe NEt Q1v a bond H a bond NH O NH Q3aOH 2348 CMe NEt Q1v a bond H a bond NH O NH Q3b OH 2349 CMe NEt Q1v abond H a bond NH O NH Q3c OH 2350 CMe NEt Q1v a bond H a bond NH O abond Q3a OH 2351 CMe NEt Q1v a bond H a bond NH O a bond Q3b OH 2352 CMeNEt Q1v a bond H a bond NH O a bond Q3c OH 2353 CMe NEt Q1w a bond Me abond NH S NH Q3a OH 2354 CMe NEt Q1w a bond Me a bond NH S NH Q3b OH2355 CMe NEt Q1w a bond Me a bond NH S NH Q3c OH 2356 CMe NEt Q1w a bondMe a bond NH S a bond Q3a OH 2357 CMe NEt Q1w a bond Me a bond NH S abond Q3b OH 2358 CMe NEt Q1w a bond Me a bond NH S a bond Q3c OH 2359CMe NEt Q1w a bond Me a bond NH O NH Q3a OH 2360 CMe NEt Q1w a bond Me abond NH O NH Q3b OH 2361 CMe NEt Q1w a bond Me a bond NH O NH Q3c OH2362 CMe NEt Q1w a bond Me a bond NH O a bond Q3a OH 2363 CMe NEt Q1w abond Me a bond NH O a bond Q3b OH 2364 CMe NEt Q1w a bond Me a bond NH Oa bond Q3c OH 2365 CMe NEt Q1w a bond H a bond NH S NH Q3a OH 2366 CMeNEt Q1w a bond H a bond NH S NH Q3b OH 2367 CMe NEt Q1w a bond H a bondNH S NH Q3c OH 2368 CMe NEt Q1w a bond H a bond NH S a bond Q3a OH 2369CMe NEt Q1w a bond H a bond NH S a bond Q3b OH 2370 CMe NEt Q1w a bond Ha bond NH S a bond Q3c OH 2371 CMe NEt Q1w a bond H a bond NH O NH Q3aOH 2372 CMe NEt Q1w a bond H a bond NH O NH Q3b OH 2373 CMe NEt Q1w abond H a bond NH O NH Q3c OH 2374 CMe NEt Q1w a bond H a bond NH O abond Q3a OH 2375 CMe NEt Q1w a bond H a bond NH O a bond Q3b OH 2376 CMeNEt Q1w a bond H a bond NH O a bond Q3c OH 2377 CMe NEt Q1x a bond Me abond NH S NH Q3a OH 2378 CMe NEt Q1x a bond Me a bond NH S NH Q3b OH2379 CMe NEt Q1x a bond Me a bond NH S NH Q3c OH 2380 CMe NEt Q1x a bondMe a bond NH S a bond Q3a OH 2381 CMe NEt Q1x a bond Me a bond NH S abond Q3b OH 2382 CMe NEt Q1x a bond Me a bond NH S a bond Q3c OH 2383CMe NEt Q1x a bond Me a bond NH O NH Q3a OH 2384 CMe NEt Q1x a bond Me abond NH O NH Q3b OH 2385 CMe NEt Q1x a bond Me a bond NH O NH Q3c OH2386 CMe NEt Q1x a bond Me a bond NH O a bond Q3a OH 2387 CMe NEt Q1x abond Me a bond NH O a bond Q3b OH 2388 CMe NEt Q1x a bond Me a bond NH Oa bond Q3c OH 2389 CMe NEt Q1x a bond H a bond NH S NH Q3a OH 2390 CMeNEt Q1x a bond H a bond NH S NH Q3b OH 2391 CMe NEt Q1x a bond H a bondNH S NH Q3c OH 2392 CMe NEt Q1x a bond H a bond NH S a bond Q3a OH 2393CMe NEt Q1x a bond H a bond NH S a bond Q3b OH 2394 CMe NEt Q1x a bond Ha bond NH S a bond Q3c OH 2395 CMe NEt Q1x a bond H a bond NH O NH Q3aOH 2396 CMe NEt Q1x a bond H a bond NH O NH Q3b OH 2397 CMe NEt Q1x abond H a bond NH O NH Q3c OH 2398 CMe NEt Q1x a bond H a bond NH O abond Q3a OH 2399 CMe NEt Q1x a bond H a bond NH O a bond Q3b OH 2400 CMeNEt Q1x a bond H a bond NH O a bond Q3c OH 2401 CMe S Q1o a bond Me abond NH S NH Q3a OH 2402 CMe S Q1o a bond Me a bond NH S NH Q3b OH 2403CMe S Q1o a bond Me a bond NH S NH Q3c OH 2404 CMe S Q1o a bond Me abond NH S a bond Q3a OH 2405 CMe S Q1o a bond Me a bond NH S a bond Q3bOH 2406 CMe S Q1o a bond Me a bond NH S a bond Q3c OH 2407 CMe S Q1o abond Me a bond NH O NH Q3a OH 2408 CMe S Q1o a bond Me a bond NH O NHQ3b OH 2409 CMe S Q1o a bond Me a bond NH O NH Q3c OH 2410 CMe S Q1o abond Me a bond NH O a bond Q3a OH 2411 CMe S Q1o a bond Me a bond NH O abond Q3b OH 2412 CMe S Q1o a bond Me a bond NH O a bond Q3c OH 2413 CMeS Q1o a bond H a bond NH S NH Q3a OH 2414 CMe S Q1o a bond H a bond NH SNH Q3b OH 2415 CMe S Q1o a bond H a bond NH S NH Q3c OH 2416 CMe S Q1o abond H a bond NH S a bond Q3a OH 2417 CMe S Q1o a bond H a bond NH S abond Q3b OH 2418 CMe S Q1o a bond H a bond NH S a bond Q3c OH 2419 CMe SQ1o a bond H a bond NH O NH Q3a OH 2420 CMe S Q1o a bond H a bond NH ONH Q3b OH 2421 CMe S Q1o a bond H a bond NH O NH Q3c OH 2422 CMe S Q1o abond H a bond NH O a bond Q3a OH 2423 CMe S Q1o a bond H a bond NH O abond Q3b OH 2424 CMe S Q1o a bond H a bond NH O a bond Q3c OH 2425 CMe SQ1p a bond Me a bond NH S NH Q3a OH 2426 CMe S Q1p a bond Me a bond NH SNH Q3b OH 2427 CMe S Q1p a bond Me a bond NH S NH Q3c OH 2428 CMe S Q1pa bond Me a bond NH S a bond Q3a OH 2429 CMe S Q1p a bond Me a bond NH Sa bond Q3b OH 2430 CMe S Q1p a bond Me a bond NH S a bond Q3c OH 2431CMe S Q1p a bond Me a bond NH O NH Q3a OH 2432 CMe S Q1p a bond Me abond NH O NH Q3b OH 2433 CMe S Q1p a bond Me a bond NH O NH Q3c OH 2434CMe S Q1p a bond Me a bond NH O a bond Q3a OH 2435 CMe S Q1p a bond Me abond NH O a bond Q3b OH 2436 CMe S Q1p a bond Me a bond NH O a bond Q3cOH 2437 CMe S Q1p a bond H a bond NH S NH Q3a OH 2438 CMe S Q1p a bond Ha bond NH S NH Q3b OH 2439 CMe S Q1p a bond H a bond NH S NH Q3c OH 2440CMe S Q1p a bond H a bond NH S a bond Q3a OH 2441 CMe S Q1p a bond H abond NH S a bond Q3b OH 2442 CMe S Q1p a bond H a bond NH S a bond Q3cOH 2443 CMe S Q1p a bond H a bond NH O NH Q3a OH 2444 CMe S Q1p a bond Ha bond NH O NH Q3b OH 2445 CMe S Q1p a bond H a bond NH O NH Q3c OH 2446CMe S Q1p a bond H a bond NH O a bond Q3a OH 2447 CMe S Q1p a bond H abond NH O a bond Q3b OH 2448 CMe S Q1p a bond H a bond NH O a bond Q3cOH 2449 CMe S Q1q a bond Me a bond NH S NH Q3a OH 2450 CMe S Q1q a bondMe a bond NH S NH Q3b OH 2451 CMe S Q1q a bond Me a bond NH S NH Q3c OH2452 CMe S Q1q a bond Me a bond NH S a bond Q3a OH 2453 CMe S Q1q a bondMe a bond NH S a bond Q3b OH 2454 CMe S Q1q a bond Me a bond NH S a bondQ3c OH 2455 CMe S Q1q a bond Me a bond NH O NH Q3a OH 2456 CMe S Q1q abond Me a bond NH O NH Q3b OH 2457 CMe S Q1q a bond Me a bond NH O NHQ3c OH 2458 CMe S Q1q a bond Me a bond NH O a bond Q3a OH 2459 CMe S Q1qa bond Me a bond NH O a bond Q3b OH 2460 CMe S Q1q a bond Me a bond NH Oa bond Q3c OH 2461 CMe S Q1q a bond H a bond NH S NH Q3a OH 2462 CMe SQ1q a bond H a bond NH S NH Q3b OH 2463 CMe S Q1q a bond H a bond NH SNH Q3c OH 2464 CMe S Q1q a bond H a bond NH S a bond Q3a OH 2465 CMe SQ1q a bond H a bond NH S a bond Q3b OH 2466 CMe S Q1q a bond H a bond NHS a bond Q3c OH 2467 CMe S Q1q a bond H a bond NH O NH Q3a OH 2468 CMe SQ1q a bond H a bond NH O NH Q3b OH 2469 CMe S Q1q a bond H a bond NH ONH Q3c OH 2470 CMe S Q1q a bond H a bond NH O a bond Q3a OH 2471 CMe SQ1q a bond H a bond NH O a bond Q3b OH 2472 CMe S Q1q a bond H a bond NHO a bond Q3c OH 2473 CMe S Q1r a bond Me a bond NH S NH Q3a OH 2474 CMeS Q1r a bond Me a bond NH S NH Q3b OH 2475 CMe S Q1r a bond Me a bond NHS NH Q3c OH 2476 CMe S Q1r a bond Me a bond NH S a bond Q3a OH 2477 CMeS Q1r a bond Me a bond NH S a bond Q3b OH 2478 CMe S Q1r a bond Me abond NH S a bond Q3c OH 2479 CMe S Q1r a bond Me a bond NH O NH Q3a OH2480 CMe S Q1r a bond Me a bond NH O NH Q3b OH 2481 CMe S Q1r a bond Mea bond NH O NH Q3c OH 2482 CMe S Q1r a bond Me a bond NH O a bond Q3a OH2483 CMe S Q1r a bond Me a bond NH O a bond Q3b OH 2484 CMe S Q1r a bondMe a bond NH O a bond Q3c OH 2485 CMe S Q1r a bond H a bond NH S NH Q3aOH 2486 CMe S Q1r a bond H a bond NH S NH Q3b OH 2487 CMe S Q1r a bond Ha bond NH S NH Q3c OH 2488 CMe S Q1r a bond H a bond NH S a bond Q3a OH2489 CMe S Q1r a bond H a bond NH S a bond Q3b OH 2490 CMe S Q1r a bondH a bond NH S a bond Q3c OH 2491 CMe S Q1r a bond H a bond NH O NH Q3aOH 2492 CMe S Q1r a bond H a bond NH O NH Q3b OH 2493 CMe S Q1r a bond Ha bond NH O NH Q3c OH 2494 CMe S Q1r a bond H a bond NH O a bond Q3a OH2495 CMe S Q1r a bond H a bond NH O a bond Q3b OH 2496 CMe S Q1r a bondH a bond NH O a bond Q3c OH 2497 CMe S Q1s a bond Me a bond NH S NH Q3aOH 2498 CMe S Q1s a bond Me a bond NH S NH Q3b OH 2499 CMe S Q1s a bondMe a bond NH S NH Q3c OH 2500 CMe S Q1s a bond Me a bond NH S a bond Q3aOH 2501 CMe S Q1s a bond Me a bond NH S a bond Q3b OH 2502 CMe S Q1s abond Me a bond NH S a bond Q3c OH 2503 CMe S Q1s a bond Me a bond NH ONH Q3a OH 2504 CMe S Q1s a bond Me a bond NH O NH Q3b OH 2505 CMe S Q1sa bond Me a bond NH O NH Q3c OH 2506 CMe S Q1s a bond Me a bond NH O abond Q3a OH 2507 CMe S Q1s a bond Me a bond NH O a bond Q3b OH 2508 CMeS Q1s a bond Me a bond NH O a bond Q3c OH 2509 CMe S Q1s a bond H a bondNH S NH Q3a OH 2510 CMe S Q1s a bond H a bond NH S NH Q3b OH 2511 CMe SQ1s a bond H a bond NH S NH Q3c OH 2512 CMe S Q1s a bond H a bond NH S abond Q3a OH 2513 CMe S Q1s a bond H a bond NH S a bond Q3b OH 2514 CMe SQ1s a bond H a bond NH S a bond Q3c OH 2515 CMe S Q1s a bond H a bond NHO NH Q3a OH 2516 CMe S Q1s a bond H a bond NH O NH Q3b OH 2517 CMe S Q1sa bond H a bond NH O NH Q3c OH 2518 CMe S Q1s a bond H a bond NH O abond Q3a OH 2519 CMe S Q1s a bond H a bond NH O a bond Q3b OH 2520 CMe SQ1s a bond H a bond NH O a bond Q3c OH 2521 CMe S Q1t a bond Me a bondNH S NH Q3a OH 2522 CMe S Q1t a bond Me a bond NH S NH Q3b OH 2523 CMe SQ1t a bond Me a bond NH S NH Q3c OH 2524 CMe S Q1t a bond Me a bond NH Sa bond Q3a OH 2525 CMe S Q1t a bond Me a bond NH S a bond Q3b OH 2526CMe S Q1t a bond Me a bond NH S a bond Q3c OH 2527 CMe S Q1t a bond Me abond NH O NH Q3a OH 2528 CMe S Q1t a bond Me a bond NH O NH Q3b OH 2529CMe S Q1t a bond Me a bond NH O NH Q3c OH 2530 CMe S Q1t a bond Me abond NH O a bond Q3a OH 2531 CMe S Q1t a bond Me a bond NH O a bond Q3bOH 2532 CMe S Q1t a bond Me a bond NH O a bond Q3c OH 2533 CMe S Q1t abond H a bond NH S NH Q3a OH 2534 CMe S Q1t a bond H a bond NH S NH Q3bOH 2535 CMe S Q1t a bond H a bond NH S NH Q3c OH 2536 CMe S Q1t a bond Ha bond NH S a bond Q3a OH 2537 CMe S Q1t a bond H a bond NH S a bond Q3bOH 2538 CMe S Q1t a bond H a bond NH S a bond Q3c OH 2539 CMe S Q1t abond H a bond NH O NH Q3a OH 2540 CMe S Q1t a bond H a bond NH O NH Q3bOH 2541 CMe S Q1t a bond H a bond NH O NH Q3c OH 2542 CMe S Q1t a bond Ha bond NH O a bond Q3a OH 2543 CMe S Q1t a bond H a bond NH O a bond Q3bOH 2544 CMe S Q1t a bond H a bond NH O a bond Q3c OH 2545 CMe S Q1u abond Me a bond NH S NH Q3a OH 2546 CMe S Q1u a bond Me a bond NH S NHQ3b OH 2547 CMe S Q1u a bond Me a bond NH S NH Q3c OH 2548 CMe S Q1u abond Me a bond NH S a bond Q3a OH 2549 CMe S Q1u a bond Me a bond NH S abond Q3b OH 2550 CMe S Q1u a bond Me a bond NH S a bond Q3c OH 2551 CMeS Q1u a bond Me a bond NH O NH Q3a OH 2552 CMe S Q1u a bond Me a bond NHO NH Q3b OH 2553 CMe S Q1u a bond Me a bond NH O NH Q3c OH 2554 CMe SQ1u a bond Me a bond NH O a bond Q3a OH 2555 CMe S Q1u a bond Me a bondNH O a bond Q3b OH 2556 CMe S Q1u a bond Me a bond NH O a bond Q3c OH2557 CMe S Q1u a bond H a bond NH S NH Q3a OH 2558 CMe S Q1u a bond H abond NH S NH Q3b OH 2559 CMe S Q1u a bond H a bond NH S NH Q3c OH 2560CMe S Q1u a bond H a bond NH S a bond Q3a OH 2561 CMe S Q1u a bond H abond NH S a bond Q3b OH 2562 CMe S Q1u a bond H a bond NH S a bond Q3cOH 2563 CMe S Q1u a bond H a bond NH O NH Q3a OH 2564 CMe S Q1u a bond Ha bond NH O NH Q3b OH 2565 CMe S Q1u a bond H a bond NH O NH Q3c OH 2566CMe S Q1u a bond H a bond NH O a bond Q3a OH 2567 CMe S Q1u a bond H abond NH O a bond Q3b OH 2568 CMe S Q1u a bond H a bond NH O a bond Q3cOH 2569 CMe S Q1v a bond Me a bond NH S NH Q3a OH 2570 CMe S Q1v a bondMe a bond NH S NH Q3b OH 2571 CMe S Q1v a bond Me a bond NH S NH Q3c OH2572 CMe S Q1v a bond Me a bond NH S a bond Q3a OH 2573 CMe S Q1v a bondMe a bond NH S a bond Q3b OH 2574 CMe S Q1v a bond Me a bond NH S a bondQ3c OH 2575 CMe S Q1v a bond Me a bond NH O NH Q3a OH 2576 CMe S Q1v abond Me a bond NH O NH Q3b OH 2577 CMe S Q1v a bond Me a bond NH O NHQ3c OH 2578 CMe S Q1v a bond Me a bond NH O a bond Q3a OH 2579 CMe S Q1va bond Me a bond NH O a bond Q3b OH 2580 CMe S Q1v a bond Me a bond NH Oa bond Q3c OH 2581 CMe S Q1v a bond H a bond NH S NH Q3a OH 2582 CMe SQ1v a bond H a bond NH S NH Q3b OH 2583 CMe S Q1v a bond H a bond NH SNH Q3c OH 2584 CMe S Q1v a bond H a bond NH S a bond Q3a OH 2585 CMe SQ1v a bond H a bond NH S a bond Q3b OH 2586 CMe S Q1v a bond H a bond NHS a bond Q3c OH 2587 CMe S Q1v a bond H a bond NH O NH Q3a OH 2588 CMe SQ1v a bond H a bond NH O NH Q3b OH 2589 CMe S Q1v a bond H a bond NH ONH Q3c OH 2590 CMe S Q1v a bond H a bond NH O a bond Q3a OH 2591 CMe SQ1v a bond H a bond NH O a bond Q3b OH 2592 CMe S Q1v a bond H a bond NHO a bond Q3c OH 2593 CMe S Q1w a bond Me a bond NH S NH Q3a OH 2594 CMeS Q1w a bond Me a bond NH S NH Q3b OH 2595 CMe S Q1w a bond Me a bond NHS NH Q3c OH 2596 CMe S Q1w a bond Me a bond NH S a bond Q3a OH 2597 CMeS Q1w a bond Me a bond NH S a bond Q3b OH 2598 CMe S Q1w a bond Me abond NH S a bond Q3c OH 2599 CMe S Q1w a bond Me a bond NH O NH Q3a OH2600 CMe S Q1w a bond Me a bond NH O NH Q3b OH 2601 CMe S Q1w a bond Mea bond NH O NH Q3c OH 2602 CMe S Q1w a bond Me a bond NH O a bond Q3a OH2603 CMe S Q1w a bond Me a bond NH O a bond Q3b OH 2604 CMe S Q1w a bondMe a bond NH O a bond Q3c OH 2605 CMe S Q1w a bond H a bond NH S NH Q3aOH 2606 CMe S Q1w a bond H a bond NH S NH Q3b OH 2607 CMe S Q1w a bond Ha bond NH S NH Q3c OH 2608 CMe S Q1w a bond H a bond NH S a bond Q3a OH2609 CMe S Q1w a bond H a bond NH S a bond Q3b OH 2610 CMe S Q1w a bondH a bond NH S a bond Q3c OH 2611 CMe S Q1w a bond H a bond NH O NH Q3aOH 2612 CMe S Q1w a bond H a bond NH O NH Q3b OH 2613 CMe S Q1w a bond Ha bond NH O NH Q3c OH 2614 CMe S Q1w a bond H a bond NH O a bond Q3a OH2615 CMe S Q1w a bond H a bond NH O a bond Q3b OH 2616 CMe S Q1w a bondH a bond NH O a bond Q3c OH 2617 CMe S Q1x a bond Me a bond NH S NH Q3aOH 2618 CMe S Q1x a bond Me a bond NH S NH Q3b OH 2619 CMe S Q1x a bondMe a bond NH S NH Q3c OH 2620 CMe S Q1x a bond Me a bond NH S a bond Q3aOH 2621 CMe S Q1x a bond Me a bond NH S a bond Q3b OH 2622 CMe S Q1x abond Me a bond NH S a bond Q3c OH 2623 CMe S Q1x a bond Me a bond NH ONH Q3a OH 2624 CMe S Q1x a bond Me a bond NH O NH Q3b OH 2625 CMe S Q1xa bond Me a bond NH O NH Q3c OH 2626 CMe S Q1x a bond Me a bond NH O abond Q3a OH 2627 CMe S Q1x a bond Me a bond NH O a bond Q3b OH 2628 CMeS Q1x a bond Me a bond NH O a bond Q3c OH 2629 CMe S Q1x a bond H a bondNH S NH Q3a OH 2630 CMe S Q1x a bond H a bond NH S NH Q3b OH 2631 CMe SQ1x a bond H a bond NH S NH Q3c OH 2632 CMe S Q1x a bond H a bond NH S abond Q3a OH 2633 CMe S Q1x a bond H a bond NH S a bond Q3b OH 2634 CMe SQ1x a bond H a bond NH S a bond Q3c OH 2635 CMe S Q1x a bond H a bond NHO NH Q3a OH 2636 CMe S Q1x a bond H a bond NH O NH Q3b OH 2637 CMe S Q1xa bond H a bond NH O NH Q3c OH 2638 CMe S Q1x a bond H a bond NH O abond Q3a OH 2639 CMe S Q1x a bond H a bond NH O a bond Q3b OH 2640 CMe SQ1x a bond H a bond NH O a bond Q3c OH 2641 CMe O Q1o a bond Me a bondNH S NH Q3a OH 2642 CMe O Q1o a bond Me a bond NH S NH Q3b OH 2643 CMe OQ1o a bond Me a bond NH S NH Q3c OH 2644 CMe O Q1o a bond Me a bond NH Sa bond Q3a OH 2645 CMe O Q1o a bond Me a bond NH S a bond Q3b OH 2646CMe O Q1o a bond Me a bond NH S a bond Q3c OH 2647 CMe O Q1o a bond Me abond NH O NH Q3a OH 2648 CMe O Q1o a bond Me a bond NH O NH Q3b OH 2649CMe O Q1o a bond Me a bond NH O NH Q3c OH 2650 CMe O Q1o a bond Me abond NH O a bond Q3a OH 2651 CMe O Q1o a bond Me a bond NH O a bond Q3bOH 2652 CMe O Q1o a bond Me a bond NH O a bond Q3c OH 2653 CMe O Q1o abond H a bond NH S NH Q3a OH 2654 CMe O Q1o a bond H a bond NH S NH Q3bOH 2655 CMe O Q1o a bond H a bond NH S NH Q3c OH 2656 CMe O Q1o a bond Ha bond NH S a bond Q3a OH 2657 CMe O Q1o a bond H a bond NH S a bond Q3bOH 2658 CMe O Q1o a bond H a bond NH S a bond Q3c OH 2659 CMe O Q1o abond H a bond NH O NH Q3a OH 2660 CMe O Q1o a bond H a bond NH O NH Q3bOH 2661 CMe O Q1o a bond H a bond NH O NH Q3c OH 2662 CMe O Q1o a bond Ha bond NH O a bond Q3a OH 2663 CMe O Q1o a bond H a bond NH O a bond Q3bOH 2664 CMe O Q1o a bond H a bond NH O a bond Q3c OH 2665 CMe O Q1p abond Me a bond NH S NH Q3a OH 2666 CMe O Q1p a bond Me a bond NH S NHQ3b OH 2667 CMe O Q1p a bond Me a bond NH S NH Q3c OH 2668 CMe O Q1p abond Me a bond NH S a bond Q3a OH 2669 CMe O Q1p a bond Me a bond NH S abond Q3b OH 2670 CMe O Q1p a bond Me a bond NH S a bond Q3c OH 2671 CMeO Q1p a bond Me a bond NH O NH Q3a OH 2672 CMe O Q1p a bond Me a bond NHO NH Q3b OH 2673 CMe O Q1p a bond Me a bond NH O NH Q3c OH 2674 CMe OQ1p a bond Me a bond NH O a bond Q3a OH 2675 CMe O Q1p a bond Me a bondNH O a bond Q3b OH 2676 CMe O Q1p a bond Me a bond NH O a bond Q3c OH2677 CMe O Q1p a bond H a bond NH S NH Q3a OH 2678 CMe O Q1p a bond H abond NH S NH Q3b OH 2679 CMe O Q1p a bond H a bond NH S NH Q3c OH 2680CMe O Q1p a bond H a bond NH S a bond Q3a OH 2681 CMe O Q1p a bond H abond NH S a bond Q3b OH 2682 CMe O Q1p a bond H a bond NH S a bond Q3cOH 2683 CMe O Q1p a bond H a bond NH O NH Q3a OH 2684 CMe O Q1p a bond Ha bond NH O NH Q3b OH 2685 CMe O Q1p a bond H a bond NH O NH Q3c OH 2686CMe O Q1p a bond H a bond NH O a bond Q3a OH 2687 CMe O Q1p a bond H abond NH O a bond Q3b OH 2688 CMe O Q1p a bond H a bond NH O a bond Q3cOH 2689 CMe O Q1q a bond Me a bond NH S NH Q3a OH 2690 CMe O Q1q a bondMe a bond NH S NH Q3b OH 2691 CMe O Q1q a bond Me a bond NH S NH Q3c OH2692 CMe O Q1q a bond Me a bond NH S a bond Q3a OH 2693 CMe O Q1q a bondMe a bond NH S a bond Q3b OH 2694 CMe O Q1q a bond Me a bond NH S a bondQ3c OH 2695 CMe O Q1q a bond Me a bond NH O NH Q3a OH 2696 CMe O Q1q abond Me a bond NH O NH Q3b OH 2697 CMe O Q1q a bond Me a bond NH O NHQ3c OH 2698 CMe O Q1q a bond Me a bond NH O a bond Q3a OH 2699 CMe O Q1qa bond Me a bond NH O a bond Q3b OH 2700 CMe O Q1q a bond Me a bond NH Oa bond Q3c OH 2701 CMe O Q1q a bond H a bond NH S NH Q3a OH 2702 CMe OQ1q a bond H a bond NH S NH Q3b OH 2703 CMe O Q1q a bond H a bond NH SNH Q3c OH 2704 CMe O Q1q a bond H a bond NH S a bond Q3a OH 2705 CMe OQ1q a bond H a bond NH S a bond Q3b OH 2706 CMe O Q1q a bond H a bond NHS a bond Q3c OH 2707 CMe O Q1q a bond H a bond NH O NH Q3a OH 2708 CMe OQ1q a bond H a bond NH O NH Q3b OH 2709 CMe O Q1q a bond H a bond NH ONH Q3c OH 2710 CMe O Q1q a bond H a bond NH O a bond Q3a OH 2711 CMe OQ1q a bond H a bond NH O a bond Q3b OH 2712 CMe O Q1q a bond H a bond NHO a bond Q3c OH 2713 CMe O Q1r a bond Me a bond NH S NH Q3a OH 2714 CMeO Q1r a bond Me a bond NH S NH Q3b OH 2715 CMe O Q1r a bond Me a bond NHS NH Q3c OH 2716 CMe O Q1r a bond Me a bond NH S a bond Q3a OH 2717 CMeO Q1r a bond Me a bond NH S a bond Q3b OH 2718 CMe O Q1r a bond Me abond NH S a bond Q3c OH 2719 CMe O Q1r a bond Me a bond NH O NH Q3a OH2720 CMe O Q1r a bond Me a bond NH O NH Q3b OH 2721 CMe O Q1r a bond Mea bond NH O NH Q3c OH 2722 CMe O Q1r a bond Me a bond NH O a bond Q3a OH2723 CMe O Q1r a bond Me a bond NH O a bond Q3b OH 2724 CMe O Q1r a bondMe a bond NH O a bond Q3c OH 2725 CMe O Q1r a bond H a bond NH S NH Q3aOH 2726 CMe O Q1r a bond H a bond NH S NH Q3b OH 2727 CMe O Q1r a bond Ha bond NH S NH Q3c OH 2728 CMe O Q1r a bond H a bond NH S a bond Q3a OH2729 CMe O Q1r a bond H a bond NH S a bond Q3b OH 2730 CMe O Q1r a bondH a bond NH S a bond Q3c OH 2731 CMe O Q1r a bond H a bond NH O NH Q3aOH 2732 CMe O Q1r a bond H a bond NH O NH Q3b OH 2733 CMe O Q1r a bond Ha bond NH O NH Q3c OH 2734 CMe O Q1r a bond H a bond NH O a bond Q3a OH2735 CMe O Q1r a bond H a bond NH O a bond Q3b OH 2736 CMe O Q1r a bondH a bond NH O a bond Q3c OH 2737 CMe O Q1s a bond Me a bond NH S NH Q3aOH 2738 CMe O Q1s a bond Me a bond NH S NH Q3b OH 2739 CMe O Q1s a bondMe a bond NH S NH Q3c OH 2740 CMe O Q1s a bond Me a bond NH S a bond Q3aOH 2741 CMe O Q1s a bond Me a bond NH S a bond Q3b OH 2742 CMe O Q1s abond Me a bond NH S a bond Q3c OH 2743 CMe O Q1s a bond Me a bond NH ONH Q3a OH 2744 CMe O Q1s a bond Me a bond NH O NH Q3b OH 2745 CMe O Q1sa bond Me a bond NH O NH Q3c OH 2746 CMe O Q1s a bond Me a bond NH O abond Q3a OH 2747 CMe O Q1s a bond Me a bond NH O a bond Q3b OH 2748 CMeO Q1s a bond Me a bond NH O a bond Q3c OH 2749 CMe O Q1s a bond H a bondNH S NH Q3a OH 2750 CMe O Q1s a bond H a bond NH S NH Q3b OH 2751 CMe OQ1s a bond H a bond NH S NH Q3c OH 2752 CMe O Q1s a bond H a bond NH S abond Q3a OH 2753 CMe O Q1s a bond H a bond NH S a bond Q3b OH 2754 CMe OQ1s a bond H a bond NH S a bond Q3c OH 2755 CMe O Q1s a bond H a bond NHO NH Q3a OH 2756 CMe O Q1s a bond H a bond NH O NH Q3b OH 2757 CMe O Q1sa bond H a bond NH O NH Q3c OH 2758 CMe O Q1s a bond H a bond NH O abond Q3a OH 2759 CMe O Q1s a bond H a bond NH O a bond Q3b OH 2760 CMe OQ1s a bond H a bond NH O a bond Q3c OH 2761 CMe O Q1t a bond Me a bondNH S NH Q3a OH 2762 CMe O Q1t a bond Me a bond NH S NH Q3b OH 2763 CMe OQ1t a bond Me a bond NH S NH Q3c OH 2764 CMe O Q1t a bond Me a bond NH Sa bond Q3a OH 2765 CMe O Q1t a bond Me a bond NH S a bond Q3b OH 2766CMe O Q1t a bond Me a bond NH S a bond Q3c OH 2767 CMe O Q1t a bond Me abond NH O NH Q3a OH 2768 CMe O Q1t a bond Me a bond NH O NH Q3b OH 2769CMe O Q1t a bond Me a bond NH O NH Q3c OH 2770 CMe O Q1t a bond Me abond NH O a bond Q3a OH 2771 CMe O Q1t a bond Me a bond NH O a bond Q3bOH 2772 CMe O Q1t a bond Me a bond NH O a bond Q3c OH 2773 CMe O Q1t abond H a bond NH S NH Q3a OH 2774 CMe O Q1t a bond H a bond NH S NH Q3bOH 2775 CMe O Q1t a bond H a bond NH S NH Q3c OH 2776 CMe O Q1t a bond Ha bond NH S a bond Q3a OH 2777 CMe O Q1t a bond H a bond NH S a bond Q3bOH 2778 CMe O Q1t a bond H a bond NH S a bond Q3c OH 2779 CMe O Q1t abond H a bond NH O NH Q3a OH 2780 CMe O Q1t a bond H a bond NH O NH Q3bOH 2781 CMe O Q1t a bond H a bond NH O NH Q3c OH 2782 CMe O Q1t a bond Ha bond NH O a bond Q3a OH 2783 CMe O Q1t a bond H a bond NH O a bond Q3bOH 2784 CMe O Q1t a bond H a bond NH O a bond Q3c OH 2785 CMe O Q1u abond Me a bond NH S NH Q3a OH 2786 CMe O Q1u a bond Me a bond NH S NHQ3b OH 2787 CMe O Q1u a bond Me a bond NH S NH Q3c OH 2788 CMe O Q1u abond Me a bond NH S a bond Q3a OH 2789 CMe O Q1u a bond Me a bond NH S abond Q3b OH 2790 CMe O Q1u a bond Me a bond NH S a bond Q3c OH 2791 CMeO Q1u a bond Me a bond NH O NH Q3a OH 2792 CMe O Q1u a bond Me a bond NHO NH Q3b OH 2793 CMe O Q1u a bond Me a bond NH O NH Q3c OH 2794 CMe OQ1u a bond Me a bond NH O a bond Q3a OH 2795 CMe O Q1u a bond Me a bondNH O a bond Q3b OH 2796 CMe O Q1u a bond Me a bond NH O a bond Q3c OH2797 CMe O Q1u a bond H a bond NH S NH Q3a OH 2798 CMe O Q1u a bond H abond NH S NH Q3b OH 2799 CMe O Q1u a bond H a bond NH S NH Q3c OH 2800CMe O Q1u a bond H a bond NH S a bond Q3a OH 2801 CMe O Q1u a bond H abond NH S a bond Q3b OH 2802 CMe O Q1u a bond H a bond NH S a bond Q3cOH 2803 CMe O Q1u a bond H a bond NH O NH Q3a OH 2804 CMe O Q1u a bond Ha bond NH O NH Q3b OH 2805 CMe O Q1u a bond H a bond NH O NH Q3c OH 2806CMe O Q1u a bond H a bond NH O a bond Q3a OH 2807 CMe O Q1u a bond H abond NH O a bond Q3b OH 2808 CMe O Q1u a bond H a bond NH O a bond Q3cOH 2809 CMe O Q1v a bond Me a bond NH S NH Q3a OH 2810 CMe O Q1v a bondMe a bond NH S NH Q3b OH 2811 CMe O Q1v a bond Me a bond NH S NH Q3c OH2812 CMe O Q1v a bond Me a bond NH S a bond Q3a OH 2813 CMe O Q1v a bondMe a bond NH S a bond Q3b OH 2814 CMe O Q1v a bond Me a bond NH S a bondQ3c OH 2815 CMe O Q1v a bond Me a bond NH O NH Q3a OH 2816 CMe O Q1v abond Me a bond NH O NH Q3b OH 2817 CMe O Q1v a bond Me a bond NH O NHQ3c OH 2818 CMe O Q1v a bond Me a bond NH O a bond Q3a OH 2819 CMe O Q1va bond Me a bond NH O a bond Q3b OH 2820 CMe O Q1v a bond Me a bond NH Oa bond Q3c OH 2821 CMe O Q1v a bond H a bond NH S NH Q3a OH 2822 CMe OQ1v a bond H a bond NH S NH Q3b OH 2823 CMe O Q1v a bond H a bond NH SNH Q3c OH 2824 CMe O Q1v a bond H a bond NH S a bond Q3a OH 2825 CMe OQ1v a bond H a bond NH S a bond Q3b OH 2826 CMe O Q1v a bond H a bond NHS a bond Q3c OH 2827 CMe O Q1v a bond H a bond NH O NH Q3a OH 2828 CMe OQ1v a bond H a bond NH O NH Q3b OH 2829 CMe O Q1v a bond H a bond NH ONH Q3c OH 2830 CMe O Q1v a bond H a bond NH O a bond Q3a OH 2831 CMe OQ1v a bond H a bond NH O a bond Q3b OH 2832 CMe O Q1v a bond H a bond NHO a bond Q3c OH 2833 CMe O Q1w a bond Me a bond NH S NH Q3a OH 2834 CMeO Q1w a bond Me a bond NH S NH Q3b OH 2835 CMe O Q1w a bond Me a bond NHS NH Q3c OH 2836 CMe O Q1w a bond Me a bond NH S a bond Q3a OH 2837 CMeO Q1w a bond Me a bond NH S a bond Q3b OH 2838 CMe O Q1w a bond Me abond NH S a bond Q3c OH 2839 CMe O Q1w a bond Me a bond NH O NH Q3a OH2840 CMe O Q1w a bond Me a bond NH O NH Q3b OH 2841 CMe O Q1w a bond Mea bond NH O NH Q3c OH 2842 CMe O Q1w a bond Me a bond NH O a bond Q3a OH2843 CMe O Q1w a bond Me a bond NH O a bond Q3b OH 2844 CMe O Q1w a bondMe a bond NH O a bond Q3c OH 2845 CMe O Q1w a bond H a bond NH S NH Q3aOH 2846 CMe O Q1w a bond H a bond NH S NH Q3b OH 2847 CMe O Q1w a bond Ha bond NH S NH Q3c OH 2848 CMe O Q1w a bond H a bond NH S a bond Q3a OH2849 CMe O Q1w a bond H a bond NH S a bond Q3b OH 2850 CMe O Q1w a bondH a bond NH S a bond Q3c OH 2851 CMe O Q1w a bond H a bond NH O NH Q3aOH 2852 CMe O Q1w a bond H a bond NH O NH Q3b OH 2853 CMe O Q1w a bond Ha bond NH O NH Q3c OH 2854 CMe O Q1w a bond H a bond NH O a bond Q3a OH2855 CMe O Q1w a bond H a bond NH O a bond Q3b OH 2856 CMe O Q1w a bondH a bond NH O a bond Q3c OH 2857 CMe O Q1x a bond Me a bond NH S NH Q3aOH 2858 CMe O Q1x a bond Me a bond NH S NH Q3b OH 2859 CMe O Q1x a bondMe a bond NH S NH Q3c OH 2860 CMe O Q1x a bond Me a bond NH S a bond Q3aOH 2861 CMe O Q1x a bond Me a bond NH S a bond Q3b OH 2862 CMe O Q1x abond Me a bond NH S a bond Q3c OH 2863 CMe O Q1x a bond Me a bond NH ONH Q3a OH 2864 CMe O Q1x a bond Me a bond NH O NH Q3b OH 2865 CMe O Q1xa bond Me a bond NH O NH Q3c OH 2866 CMe O Q1x a bond Me a bond NH O abond Q3a OH 2867 CMe O Q1x a bond Me a bond NH O a bond Q3b OH 2868 CMeO Q1x a bond Me a bond NH O a bond Q3c OH 2869 CMe O Q1x a bond H a bondNH S NH Q3a OH 2870 CMe O Q1x a bond H a bond NH S NH Q3b OH 2871 CMe OQ1x a bond H a bond NH S NH Q3c OH 2872 CMe O Q1x a bond H a bond NH S abond Q3a OH 2873 CMe O Q1x a bond H a bond NH S a bond Q3b OH 2874 CMe OQ1x a bond H a bond NH S a bond Q3c OH 2875 CMe O Q1x a bond H a bond NHO NH Q3a OH 2876 CMe O Q1x a bond H a bond NH O NH Q3b OH 2877 CMe O Q1xa bond H a bond NH O NH Q3c OH 2878 CMe O Q1x a bond H a bond NH O abond Q3a OH 2879 CMe O Q1x a bond H a bond NH O a bond Q3b OH 2880 CMe OQ1x a bond H a bond NH O a bond Q3c OH 2881 CH NH Q1o a bond Me a bondNH S NH Q3a OH 2882 CH NH Q1o a bond Me a bond NH S NH Q3b OH 2883 CH NHQ1o a bond Me a bond NH S NH Q3c OH 2884 CH NH Q1o a bond Me a bond NH Sa bond Q3a OH 2885 CH NH Q1o a bond Me a bond NH S a bond Q3b OH 2886 CHNH Q1o a bond Me a bond NH S a bond Q3c OH 2887 CH NH Q1o a bond Me abond NH O NH Q3a OH 2888 CH NH Q1o a bond Me a bond NH O NH Q3b OH 2889CH NH Q1o a bond Me a bond NH O NH Q3c OH 2890 CH NH Q1o a bond Me abond NH O a bond Q3a OH 2891 CH NH Q1o a bond Me a bond NH O a bond Q3bOH 2892 CH NH Q1o a bond Me a bond NH O a bond Q3c OH 2893 CH NH Q1o abond H a bond NH S NH Q3a OH 2894 CH NH Q1o a bond H a bond NH S NH Q3bOH 2895 CH NH Q1o a bond H a bond NH S NH Q3c OH 2896 CH NH Q1o a bond Ha bond NH S a bond Q3a OH 2897 CH NH Q1o a bond H a bond NH S a bond Q3bOH 2898 CH NH Q1o a bond H a bond NH S a bond Q3c OH 2899 CH NH Q1o abond H a bond NH O NH Q3a OH 2900 CH NH Q1o a bond H a bond NH O NH Q3bOH 2901 CH NH Q1o a bond H a bond NH O NH Q3c OH 2902 CH NH Q1o a bond Ha bond NH O a bond Q3a OH 2903 CH NH Q1o a bond H a bond NH O a bond Q3bOH 2904 CH NH Q1o a bond H a bond NH O a bond Q3c OH 2905 CH NH Q1p abond Me a bond NH S NH Q3a OH 2906 CH NH Q1p a bond Me a bond NH S NHQ3b OH 2907 CH NH Q1p a bond Me a bond NH S NH Q3c OH 2908 CH NH Q1p abond Me a bond NH S a bond Q3a OH 2909 CH NH Q1p a bond Me a bond NH S abond Q3b OH 2910 CH NH Q1p a bond Me a bond NH S a bond Q3c OH 2911 CHNH Q1p a bond Me a bond NH O NH Q3a OH 2912 CH NH Q1p a bond Me a bondNH O NH Q3b OH 2913 CH NH Q1p a bond Me a bond NH O NH Q3c OH 2914 CH NHQ1p a bond Me a bond NH O a bond Q3a OH 2915 CH NH Q1p a bond Me a bondNH O a bond Q3b OH 2916 CH NH Q1p a bond Me a bond NH O a bond Q3c OH2917 CH NH Q1p a bond H a bond NH S NH Q3a OH 2918 CH NH Q1p a bond H abond NH S NH Q3b OH 2919 CH NH Q1p a bond H a bond NH S NH Q3c OH 2920CH NH Q1p a bond H a bond NH S a bond Q3a OH 2921 CH NH Q1p a bond H abond NH S a bond Q3b OH 2922 CH NH Q1p a bond H a bond NH S a bond Q3cOH 2923 CH NH Q1p a bond H a bond NH O NH Q3a OH 2924 CH NH Q1p a bond Ha bond NH O NH Q3b OH 2925 CH NH Q1p a bond H a bond NH O NH Q3c OH 2926CH NH Q1p a bond H a bond NH O a bond Q3a OH 2927 CH NH Q1p a bond H abond NH O a bond Q3b OH 2928 CH NH Q1p a bond H a bond NH O a bond Q3cOH 2929 CH NH Q1q a bond Me a bond NH S NH Q3a OH 2930 CH NH Q1q a bondMe a bond NH S NH Q3b OH 2931 CH NH Q1q a bond Me a bond NH S NH Q3c OH2932 CH NH Q1q a bond Me a bond NH S a bond Q3a OH 2933 CH NH Q1q a bondMe a bond NH S a bond Q3b OH 2934 CH NH Q1q a bond Me a bond NH S a bondQ3c OH 2935 CH NH Q1q a bond Me a bond NH O NH Q3a OH 2936 CH NH Q1q abond Me a bond NH O NH Q3b OH 2937 CH NH Q1q a bond Me a bond NH O NHQ3c OH 2938 CH NH Q1q a bond Me a bond NH O a bond Q3a OH 2939 CH NH Q1qa bond Me a bond NH O a bond Q3b OH 2940 CH NH Q1q a bond Me a bond NH Oa bond Q3c OH 2941 CH NH Q1q a bond H a bond NH S NH Q3a OH 2942 CH NHQ1q a bond H a bond NH S NH Q3b OH 2943 CH NH Q1q a bond H a bond NH SNH Q3c OH 2944 CH NH Q1q a bond H a bond NH S a bond Q3a OH 2945 CH NHQ1q a bond H a bond NH S a bond Q3b OH 2946 CH NH Q1q a bond H a bond NHS a bond Q3c OH 2947 CH NH Q1q a bond H a bond NH O NH Q3a OH 2948 CH NHQ1q a bond H a bond NH O NH Q3b OH 2949 CH NH Q1q a bond H a bond NH ONH Q3c OH 2950 CH NH Q1q a bond H a bond NH O a bond Q3a OH 2951 CH NHQ1q a bond H a bond NH O a bond Q3b OH 2952 CH NH Q1q a bond H a bond NHO a bond Q3c OH 2953 CH NH Q1r a bond Me a bond NH S NH Q3a OH 2954 CHNH Q1r a bond Me a bond NH S NH Q3b OH 2955 CH NH Q1r a bond Me a bondNH S NH Q3c OH 2956 CH NH Q1r a bond Me a bond NH S a bond Q3a OH 2957CH NH Q1r a bond Me a bond NH S a bond Q3b OH 2958 CH NH Q1r a bond Me abond NH S a bond Q3c OH 2959 CH NH Q1r a bond Me a bond NH O NH Q3a OH2960 CH NH Q1r a bond Me a bond NH O NH Q3b OH 2961 CH NH Q1r a bond Mea bond NH O NH Q3c OH 2962 CH NH Q1r a bond Me a bond NH O a bond Q3a OH2963 CH NH Q1r a bond Me a bond NH O a bond Q3b OH 2964 CH NH Q1r a bondMe a bond NH O a bond Q3c OH 2965 CH NH Q1r a bond H a bond NH S NH Q3aOH 2966 CH NH Q1r a bond H a bond NH S NH Q3b OH 2967 CH NH Q1r a bond Ha bond NH S NH Q3c OH 2968 CH NH Q1r a bond H a bond NH S a bond Q3a OH2969 CH NH Q1r a bond H a bond NH S a bond Q3b OH 2970 CH NH Q1r a bondH a bond NH S a bond Q3c OH 2971 CH NH Q1r a bond H a bond NH O NH Q3aOH 2972 CH NH Q1r a bond H a bond NH O NH Q3b OH 2973 CH NH Q1r a bond Ha bond NH O NH Q3c OH 2974 CH NH Q1r a bond H a bond NH O a bond Q3a OH2975 CH NH Q1r a bond H a bond NH O a bond Q3b OH 2976 CH NH Q1r a bondH a bond NH O a bond Q3c OH 2977 CH NH Q1s a bond Me a bond NH S NH Q3aOH 2978 CH NH Q1s a bond Me a bond NH S NH Q3b OH 2979 CH NH Q1s a bondMe a bond NH S NH Q3c OH 2980 CH NH Q1s a bond Me a bond NH S a bond Q3aOH 2981 CH NH Q1s a bond Me a bond NH S a bond Q3b OH 2982 CH NH Q1s abond Me a bond NH S a bond Q3c OH 2983 CH NH Q1s a bond Me a bond NH ONH Q3a OH 2984 CH NH Q1s a bond Me a bond NH O NH Q3b OH 2985 CH NH Q1sa bond Me a bond NH O NH Q3c OH 2986 CH NH Q1s a bond Me a bond NH O abond Q3a OH 2987 CH NH Q1s a bond Me a bond NH O a bond Q3b OH 2988 CHNH Q1s a bond Me a bond NH O a bond Q3c OH 2989 CH NH Q1s a bond H abond NH S NH Q3a OH 2990 CH NH Q1s a bond H a bond NH S NH Q3b OH 2991CH NH Q1s a bond H a bond NH S NH Q3c OH 2992 CH NH Q1s a bond H a bondNH S a bond Q3a OH 2993 CH NH Q1s a bond H a bond NH S a bond Q3b OH2994 CH NH Q1s a bond H a bond NH S a bond Q3c OH 2995 CH NH Q1s a bondH a bond NH O NH Q3a OH 2996 CH NH Q1s a bond H a bond NH O NH Q3b OH2997 CH NH Q1s a bond H a bond NH O NH Q3c OH 2998 CH NH Q1s a bond H abond NH O a bond Q3a OH 2999 CH NH Q1s a bond H a bond NH O a bond Q3bOH 3000 CH NH Q1s a bond H a bond NH O a bond Q3c OH 3001 CH NH Q1t abond Me a bond NH S NH Q3a OH 3002 CH NH Q1t a bond Me a bond NH S NHQ3b OH 3003 CH NH Q1t a bond Me a bond NH S NH Q3c OH 3004 CH NH Q1t abond Me a bond NH S a bond Q3a OH 3005 CH NH Q1t a bond Me a bond NH S abond Q3b OH 3006 CH NH Q1t a bond Me a bond NH S a bond Q3c OH 3007 CHNH Q1t a bond Me a bond NH O NH Q3a OH 3008 CH NH Q1t a bond Me a bondNH O NH Q3b OH 3009 CH NH Q1t a bond Me a bond NH O NH Q3c OH 3010 CH NHQ1t a bond Me a bond NH O a bond Q3a OH 3011 CH NH Q1t a bond Me a bondNH O a bond Q3b OH 3012 CH NH Q1t a bond Me a bond NH O a bond Q3c OH3013 CH NH Q1t a bond H a bond NH S NH Q3a OH 3014 CH NH Q1t a bond H abond NH S NH Q3b OH 3015 CH NH Q1t a bond H a bond NH S NH Q3c OH 3016CH NH Q1t a bond H a bond NH S a bond Q3a OH 3017 CH NH Q1t a bond H abond NH S a bond Q3b OH 3018 CH NH Q1t a bond H a bond NH S a bond Q3cOH 3019 CH NH Q1t a bond H a bond NH O NH Q3a OH 3020 CH NH Q1t a bond Ha bond NH O NH Q3b OH 3021 CH NH Q1t a bond H a bond NH O NH Q3c OH 3022CH NH Q1t a bond H a bond NH O a bond Q3a OH 3023 CH NH Q1t a bond H abond NH O a bond Q3b OH 3024 CH NH Q1t a bond H a bond NH O a bond Q3cOH 3025 CH NH Q1u a bond Me a bond NH S NH Q3a OH 3026 CH NH Q1u a bondMe a bond NH S NH Q3b OH 3027 CH NH Q1u a bond Me a bond NH S NH Q3c OH3028 CH NH Q1u a bond Me a bond NH S a bond Q3a OH 3029 CH NH Q1u a bondMe a bond NH S a bond Q3b OH 3030 CH NH Q1u a bond Me a bond NH S a bondQ3c OH 3031 CH NH Q1u a bond Me a bond NH O NH Q3a OH 3032 CH NH Q1u abond Me a bond NH O NH Q3b OH 3033 CH NH Q1u a bond Me a bond NH O NHQ3c OH 3034 CH NH Q1u a bond Me a bond NH O a bond Q3a OH 3035 CH NH Q1ua bond Me a bond NH O a bond Q3b OH 3036 CH NH Q1u a bond Me a bond NH Oa bond Q3c OH 3037 CH NH Q1u a bond H a bond NH S NH Q3a OH 3038 CH NHQ1u a bond H a bond NH S NH Q3b OH 3039 CH NH Q1u a bond H a bond NH SNH Q3c OH 3040 CH NH Q1u a bond H a bond NH S a bond Q3a OH 3041 CH NHQ1u a bond H a bond NH S a bond Q3b OH 3042 CH NH Q1u a bond H a bond NHS a bond Q3c OH 3043 CH NH Q1u a bond H a bond NH O NH Q3a OH 3044 CH NHQ1u a bond H a bond NH O NH Q3b OH 3045 CH NH Q1u a bond H a bond NH ONH Q3c OH 3046 CH NH Q1u a bond H a bond NH O a bond Q3a OH 3047 CH NHQ1u a bond H a bond NH O a bond Q3b OH 3048 CH NH Q1u a bond H a bond NHO a bond Q3c OH 3049 CH NH Q1v a bond Me a bond NH S NH Q3a OH 3050 CHNH Q1v a bond Me a bond NH S NH Q3b OH 3051 CH NH Q1v a bond Me a bondNH S NH Q3c OH 3052 CH NH Q1v a bond Me a bond NH S a bond Q3a OH 3053CH NH Q1v a bond Me a bond NH S a bond Q3b OH 3054 CH NH Q1v a bond Me abond NH S a bond Q3c OH 3055 CH NH Q1v a bond Me a bond NH O NH Q3a OH3056 CH NH Q1v a bond Me a bond NH O NH Q3b OH 3057 CH NH Q1v a bond Mea bond NH O NH Q3c OH 3058 CH NH Q1v a bond Me a bond NH O a bond Q3a OH3059 CH NH Q1v a bond Me a bond NH O a bond Q3b OH 3060 CH NH Q1v a bondMe a bond NH O a bond Q3c OH 3061 CH NH Q1v a bond H a bond NH S NH Q3aOH 3062 CH NH Q1v a bOnd H a bond NH S NH Q3b OH 3063 CH NH Q1v a bond Ha bond NH S NH Q3c OH 3064 CH NH Q1v a bond H a bond NH S a bond Q3a OH3065 CH NH Q1v a bond H a bond NH S a bond Q3b OH 3066 CH NH Q1v a bondH a bond NH S a bond Q3c OH 3067 CH NH Q1v a bond H a bond NH O NH Q3aOH 3068 CH NH Q1v a bond H a bond NH O NH Q3b OH 3069 CH NH Q1v a bond Ha bond NH O NH Q3c OH 3070 CH NH Q1v a bond H a bond NH O a bond Q3a OH3071 CH NH Q1v a bond H a bond NH O a bond Q3b OH 3072 CH NH Q1v a bondH a bond NH O a bond Q3c OH 3073 CH NH Q1w a bond Me a bond NH S NH Q3aOH 3074 CH NH Q1w a bond Me a bond NH S NH Q3b OH 3075 CH NH Q1w a bondMe a bond NH S NH Q3c OH 3076 N NMe Q1y a bond Me a bond NH O a bond Q3aOH 3077 N NMe Q1z a bond Me a bond NH O a bond Q3a OH 3078 CH NH Q1w abond Me a bond NH S a bond Q3a OH 3079 CH NH Q1w a bond Me a bond NH S abond Q3b OH 3080 CH NH Q1w a bond Me a bond NH S a bond Q3c OH 3081 CHNH Q1w a bond Me a bond NH O NH Q3a OH 3082 CH NH Q1w a bond Me a bondNH O NH Q3b OH 3083 CH NH Q1w a bond Me a bond NH O NH Q3c OH 3084 CH NHQ1w a bond Me a bond NH O a bond Q3a OH 3085 CH NH Q1w a bond Me a bondNH O a bond Q3b OH 3086 CH NH Q1w a bond Me a bond NH O a bond Q3c OH3087 CH NH Q1w a bond H a bond NH S NH Q3a OH 3088 CH NH Q1w a bond H abond NH S NH Q3b OH 3089 CH NH Q1w a bond H a bond NH S NH Q3c OH 3090CH NH Q1w a bond H a bond NH S a bond Q3a OH 3091 CH NH Q1w a bond H abond NH S a bond Q3b OH 3092 CH NH Q1w a bond H a bond NH S a bond Q3cOH 3093 CH NH Q1w a bond H a bond NH O NH Q3a OH 3094 CH NH Q1w a bond Ha bond NH O NH Q3b OH 3095 CH NH Q1w a bond H a bond NH O NH Q3c OH 3096CH NH Q1w a bond H a bond NH O a bond Q3a OH 3097 CH NH Q1w a bond H abond NH O a bond Q3b OH 3098 CH NH Q1w a bond H a bond NH O a bond Q3cOH 3099 CH NH Q1x a bond Me a bond NH S NH Q3a OH 3100 CH NH Q1x a bondMe a bond NH S NH Q3b OH 3101 CH NH Q1x a bond Me a bond NH S NH Q3c OH3102 CH NH Q1x a bond Me a bond NH S a bond Q3a OH 3103 CH NH Q1x a bondMe a bond NH S a bond Q3b OH 3104 CH NH Q1x a bond Me a bond NH S a bondQ3c OH 3105 CH NH Q1x a bond Me a bond NH O NH Q3a OH 3106 CH NH Q1x abond Me a bond NH O NH Q3b OH 3107 CH NH Q1x a bond Me a bond NH O NHQ3c OH 3108 CH NH Q1x a bond Me a bond NH O a bond Q3a OH 3109 CH NH Q1xa bond Me a bond NH O a bond Q3b OH 3110 CH NH Q1x a bond Me a bond NH Oa bond Q3c OH 3111 CH NH Q1x a bond H a bond NH S NH Q3a OH 3112 CH NHQ1x a bond H a bond NH S NH Q3b OH 3113 CH NH Q1x a bond H a bond NH SNH Q3c OH 3114 CH NH Q1x a bond H a bond NH S a bond Q3a OH 3115 CH NHQ1x a bond H a bond NH S a bond Q3b OH 3116 CH NH Q1x a bond H a bond NHS a bond Q3c OH 3117 CH NH Q1x a bond H a bond NH O NH Q3a OH 3118 CH NHQ1x a bond H a bond NH O NH Q3b OH 3119 CH NH Q1x a bond H a bond NH ONH Q3c OH 3120 CH NH Q1x a bond H a bond NH O a bond Q3a OH 3121 CH NHQ1x a bond H a bond NH O a bond Q3b OH 3122 CH NH Q1x a bond H a bond NHO a bond Q3c OH 3123 CMe NH Q1o a bond Me a bond NH S NH Q3a OH 3124 CMeNH Q1o a bond Me a bond NH S NH Q3b OH 3125 CMe NH Q1o a bond Me a bondNH S NH Q3c OH 3126 CMe NH Q1o a bond Me a bond NH S a bond Q3a OH 3127CMe NH Q1o a bond Me a bond NH S a bond Q3b OH 3128 CMe NH Q1o a bond Mea bond NH S a bond Q3c OH 3129 CMe NH Q1o a bond Me a bond NH O NH Q3aOH 3130 CMe NH Q1o a bond Me a bond NH O NH Q3b OH 3131 CMe NH Q1o abond Me a bond NH O NH Q3c OH 3132 CMe NH Q1o a bond Me a bond NH O abond Q3a OH 3133 CMe NH Q1o a bond Me a bond NH O a bond Q3b OH 3134 CMeNH Q1o a bond Me a bond NH O a bond Q3c OH 3135 CMe NH Q1o a bond H abond NH S NH Q3a OH 3136 CMe NH Q1o a bond H a bond NH S NH Q3b OH 3137CMe NH Q1o a bond H a bond NH S NH Q3c OH 3138 CMe NH Q1o a bond H abond NH S a bond Q3a OH 3139 CMe NH Q1o a bond H a bond NH S a bond Q3bOH 3140 CMe NH Q1o a bond H a bond NH S a bond Q3c OH 3141 CMe NH Q1o abond H a bond NH O NH Q3a OH 3142 CMe NH Q1o a bond H a bond NH O NH Q3bOH 3143 CMe NH Q1o a bond H a bond NH O NH Q3c OH 3144 CMe NH Q1o a bondH a bond NH O a bond Q3a OH 3145 CMe NH Q1o a bond H a bond NH O a bondQ3b OH 3146 CMe NH Q1o a bond H a bond NH O a bond Q3c OH 3147 CMe NHQ1p a bond Me a bond NH S NH Q3a OH 3148 CMe NH Q1p a bond Me a bond NHS NH Q3b OH 3149 CMe NH Q1p a bond Me a bond NH S NH Q3c OH 3150 CMe NHQ1p a bond Me a bond NH S a bond Q3a OH 3151 CMe NH Q1p a bond Me a bondNH S a bond Q3b OH 3152 CMe NH Q1p a bond Me a bond NH S a bond Q3c OH3153 CMe NH Q1p a bond Me a bond NH O NH Q3a OH 3154 CMe NH Q1p a bondMe a bond NH O NH Q3b OH 3155 CMe NH Q1p a bond Me a bond NH O NH Q3c OH3156 CMe NH Q1p a bond Me a bond NH O a bond Q3a OH 3157 CMe NH Q1p abond Me a bond NH O a bond Q3b OH 3158 CMe NH Q1p a bond Me a bond NH Oa bond Q3c OH 3159 CMe NH Q1p a bond H a bond NH S NH Q3a OH 3160 CMe NHQ1p a bond H a bond NH S NH Q3b OH 3161 CMe NH Q1p a bond H a bond NH SNH Q3c OH 3162 CMe NH Q1p a bond H a bond NH S a bond Q3a OH 3163 CMe NHQ1p a bond H a bond NH S a bond Q3b OH 3164 CMe NH Q1p a bond H a bondNH S a bond Q3c OH 3165 CMe NH Q1p a bond H a bond NH O NH Q3a OH 3166CMe NH Q1p a bond H a bond NH O NH Q3b OH 3167 CMe NH Q1p a bond H abond NH O NH Q3c OH 3168 CMe NH Q1p a bond H a bond NH O a bond Q3a OH3169 CMe NH Q1p a bond H a bond NH O a bond Q3b OH 3170 CMe NH Q1p abond H a bond NH O a bond Q3c OH 3171 CMe NH Q1q a bond Me a bond NH SNH Q3a OH 3172 CMe NH Q1q a bond Me a bond NH S NH Q3b OH 3173 CMe NHQ1q a bond Me a bond NH S NH Q3c OH 3174 CMe NH Q1q a bond Me a bond NHS a bond Q3a OH 3175 CMe NH Q1q a bond Me a bond NH S a bond Q3b OH 3176CMe NH Q1q a bond Me a bond NH S a bond Q3c OH 3177 CMe NH Q1q a bond Mea bond NH O NH Q3a OH 3178 CMe NH Q1q a bond Me a bond NH O NH Q3b OH3179 CMe NH Q1q a bond Me a bond NH O NH Q3c OH 3180 CMe NH Q1q a bondMe a bond NH O a bond Q3a OH 3181 CMe NH Q1q a bond Me a bond NH O abond Q3b OH 3182 CMe NH Q1q a bond Me a bond NH O a bond Q3c OH 3183 CMeNH Q1q a bond H a bond NH S NH Q3a OH 3184 CMe NH Q1q a bond H a bond NHS NH Q3b OH 3185 CMe NH Q1q a bond H a bond NH S NH Q3c OH 3186 CMe NHQ1q a bond H a bond NH S a bond Q3a OH 3187 CMe NH Q1q a bond H a bondNH S a bond Q3b OH 3188 CMe NH Q1q a bond H a bond NH S a bond Q3c OH3189 CMe NH Q1q a bond H a bond NH O NH Q3a OH 3190 CMe NH Q1q a bond Ha bond NH O NH Q3b OH 3191 CMe NH Q1q a bond H a bond NH O NH Q3c OH3192 CMe NH Q1q a bond H a bond NH O a bond Q3a OH 3193 CMe NH Q1q abond H a bond NH O a bond Q3b OH 3194 CMe NH Q1q a bond H a bond NH O abond Q3c OH 3195 CMe NH Q1r a bond Me a bond NH S NH Q3a OH 3196 CMe NHQ1r a bond Me a bond NH S NH Q3b OH 3197 CMe NH Q1r a bond Me a bond NHS NH Q3c OH 3198 CMe NH Q1r a bond Me a bond NH S a bond Q3a OH 3199 CMeNH Q1r a bond Me a bond NH S a bond Q3b OH 3200 CMe NH Q1r a bond Me abond NH S a bond Q3c OH 3201 CMe NH Q1r a bond Me a bond NH O NH Q3a OH3202 CMe NH Q1r a bond Me a bond NH O NH Q3b OH 3203 CMe NH Q1r a bondMe a bond NH O NH Q3c OH 3204 CMe NH Q1r a bond Me a bond NH O a bondQ3a OH 3205 CMe NH Q1r a bond Me a bond NH O a bond Q3b OH 3206 CMe NHQ1r a bond Me a bond NH O a bond Q3c OH 3207 CMe NH Q1r a bond H a bondNH S NH Q3a OH 3208 CMe NH Q1r a bond H a bond NH S NH Q3b OH 3209 CMeNH Q1r a bond H a bond NH S NH Q3c OH 3210 CMe NH Q1r a bond H a bond NHS a bond Q3a OH 3211 CMe NH Q1r a bond H a bond NH S a bond Q3b OH 3212CMe NH Q1r a bond H a bond NH S a bond Q3c OH 3213 CMe NH Q1r a bond H abond NH O NH Q3a OH 3214 CMe NH Q1r a bond H a bond NH O NH Q3b OH 3215CMe NH Q1r a bond H a bond NH O NH Q3c OH 3216 CMe NH Q1r a bond H abond NH O a bond Q3a OH 3217 CMe NH Q1r a bond H a bond NH O a bond Q3bOH 3218 CMe NH Q1r a bond H a bond NH O a bond Q3c OH 3219 CMe NH Q1s abond Me a bond NH S NH Q3a OH 3220 CMe NH Q1s a bond Me a bond NH S NHQ3b OH 3221 CMe NH Q1s a bond Me a bond NH S NH Q3c OH 3222 CMe NH Q1s abond Me a bond NH S a bond Q3a OH 3223 CMe NH Q1s a bond Me a bond NH Sa bond Q3b OH 3224 CMe NH Q1s a bond Me a bond NH S a bond Q3c OH 3225CMe NH Q1s a bond Me a bond NH O NH Q3a OH 3226 CMe NH Q1s a bond Me abond NH O NH Q3b OH 3227 CMe NH Q1s a bond Me a bond NH O NH Q3c OH 3228CMe NH Q1s a bond Me a bond NH O a bond Q3a OH 3229 CMe NH Q1s a bond Mea bond NH O a bond Q3b OH 3230 CMe NH Q1s a bond Me a bond NH O a bondQ3c OH 3231 CMe NH Q1s a bond H a bond NH S NH Q3a OH 3232 CMe NH Q1s abond H a bond NH S NH Q3b OH 3233 CMe NH Q1s a bond H a bond NH S NH Q3cOH 3234 CMe NH Q1s a bond H a bond NH S a bond Q3a OH 3235 CMe NH Q1s abond H a bond NH S a bond Q3b OH 3236 CMe NH Q1s a bond H a bond NH S abond Q3c OH 3237 CMe NH Q1s a bond H a bond NH O NH Q3a OH 3238 CMe NHQ1s a bond H a bond NH O NH Q3b OH 3239 CMe NH Q1s a bond H a bond NH ONH Q3c OH 3240 CMe NH Q1s a bond H a bond NH O a bond Q3a OH 3241 CMe NHQ1s a bond H a bond NH O a bond Q3b OH 3242 CMe NH Q1s a bond H a bondNH O a bond Q3c OH 3243 CMe NH Q1t a bond Me a bond NH S NH Q3a OH 3244CMe NH Q1t a bond Me a bond NH S NH Q3b OH 3245 CMe NH Q1t a bond Me abond NH S NH Q3c OH 3246 CMe NH Q1t a bond Me a bond NH S a bond Q3a OH3247 CMe NH Q1t a bond Me a bond NH S a bond Q3b OH 3248 CMe NH Q1t abond Me a bond NH S a bond Q3c OH 3249 CMe NH Q1t a bond Me a bond NH ONH Q3a OH 3250 CMe NH Q1t a bond Me a bond NH O NH Q3b OH 3251 CMe NHQ1t a bond Me a bond NH O NH Q3c OH 3252 CMe NH Q1t a bond Me a bond NHO a bond Q3a OH 3253 CMe NH Q1t a bond Me a bond NH O a bond Q3b OH 3254CMe NH Q1t a bond Me a bond NH O a bond Q3c OH 3255 CMe NH Q1t a bond Ha bond NH S NH Q3a OH 3256 CMe NH Q1t a bond H a bond NH S NH Q3b OH3257 CMe NH Q1t a bond H a bond NH S NH Q3c OH 3258 CMe NH Q1t a bond Ha bond NH S a bond Q3a OH 3259 CMe NH Q1t a bond H a bond NH S a bondQ3b OH 3260 CMe NH Q1t a bond H a bond NH S a bond Q3c OH 3261 CMe NHQ1t a bond H a bond NH O NH Q3a OH 3262 CMe NH Q1t a bond H a bond NH ONH Q3b OH 3263 CMe NH Q1t a bond H a bond NH O NH Q3c OH 3264 CMe NH Q1ta bond H a bond NH O a bond Q3a OH 3265 CMe NH Q1t a bond H a bond NH Oa bond Q3b OH 3266 CMe NH Q1t a bond H a bond NH O a bond Q3c OH 3267CMe NH Q1u a bond Me a bond NH S NH Q3a OH 3268 CMe NH Q1u a bond Me abond NH S NH Q3b OH 3269 CMe NH Q1u a bond Me a bond NH S NH Q3c OH 3270CMe NH Q1u a bond Me a bond NH S a bond Q3a OH 3271 CMe NH Q1u a bond Mea bond NH S a bond Q3b OH 3272 CMe NH Q1u a bond Me a bond NH S a bondQ3c OH 3273 CMe NH Q1u a bond Me a bond NH O NH Q3a OH 3274 CMe NH Q1u abond Me a bond NH O NH Q3b OH 3275 CMe NH Q1u a bond Me a bond NH O NHQ3c OH 3276 CMe NH Q1u a bond Me a bond NH O a bond Q3a OH 3277 CMe NHQ1u a bond Me a bond NH O a bond Q3b OH 3278 CMe NH Q1u a bond Me a bondNH O a bond Q3c OH 3279 CMe NH Q1u a bond H a bond NH S NH Q3a OH 3280CMe NH Q1u a bond H a bond NH S NH Q3b OH 3281 CMe NH Q1u a bond H abond NH S NH Q3c OH 3282 CMe NH Q1u a bond H a bond NH S a bond Q3a OH3283 CMe NH Q1u a bond H a bond NH S a bond Q3b OH 3284 CMe NH Q1u abond H a bond NH S a bond Q3c OH 3285 CMe NH Q1u a bond H a bond NH O NHQ3a OH 3286 CMe NH Q1u a bond H a bond NH O NH Q3b OH 3287 CMe NH Q1u abond H a bond NH O NH Q3c OH 3288 CMe NH Q1u a bond H a bond NH O a bondQ3a OH 3289 CMe NH Q1u a bond H a bond NH O a bond Q3b OH 3290 CMe NHQ1u a bond H a bond NH O a bond Q3c OH 3291 CMe NH Q1v a bond Me a bondNH S NH Q3a OH 3292 CMe NH Q1v a bond Me a bond NH S NH Q3b OH 3293 CMeNH Q1v a bond Me a bond NH S NH Q3c OH 3294 CMe NH Q1v a bond Me a bondNH S a bond Q3a OH 3295 CMe NH Q1v a bond Me a bond NH S a bond Q3b OH3296 CMe NH Q1v a bond Me a bond NH S a bond Q3c OH 3297 CMe NH Q1v abond Me a bond NH O NH Q3a OH 3298 CMe NH Q1v a bond Me a bond NH O NHQ3b OH 3299 CMe NH Q1v a bond Me a bond NH O NH Q3c OH 3300 CMe NH Q1v abond Me a bond NH O a bond Q3a OH 3301 CMe NH Q1v a bond Me a bond NH Oa bond Q3b OH 3302 CMe NH Q1v a bond Me a bond NH O a bond Q3c OH 3303CMe NH Q1v a bond H a bond NH S NH Q3a OH 3304 CMe NH Q1v a bond H abond NH S NH Q3b OH 3305 CMe NH Q1v a bond H a bond NH S NH Q3c OH 3306CMe NH Q1v a bond H a bond NH S a bond Q3a OH 3307 CMe NH Q1v a bond H abond NH S a bond Q3b OH 3308 CMe NH Q1v a bond H a bond NH S a bond Q3cOH 3309 CMe NH Q1v a bond H a bond NH O NH Q3a OH 3310 CMe NH Q1v a bondH a bond NH O NH Q3b OH 3311 CMe NH Q1v a bond H a bond NH O NH Q3c OH3312 CMe NH Q1v a bond H a bond NH O a bond Q3a OH 3313 CMe NH Q1v abond H a bond NH O a bond Q3b OH 3314 CMe NH Q1v a bond H a bond NH O abond Q3c OH 3315 CMe NH Q1w a bond Me a bond NH S NH Q3a OH 3316 CMe NHQ1w a bond Me a bond NH S NH Q3b OH 3317 CMe NH Q1w a bond Me a bond NHS NH Q3c OH 3318 CMe NH Q1w a bond Me a bond NH S a bond Q3a OH 3319 CMeNH Q1w a bond Me a bond NH S a bond Q3b OH 3320 CMe NH Q1w a bond Me abond NH S a bond Q3c OH 3321 CMe NH Q1w a bond Me a bond NH O NH Q3a OH3322 CMe NH Q1w a bond Me a bond NH O NH Q3b OH 3323 CMe NH Q1w a bondMe a bond NH O NH Q3c OH 3324 CMe NH Q1w a bond Me a bond NH O a bondQ3a OH 3325 CMe NH Q1w a bond Me a bond NH O a bond Q3b OH 3326 CMe NHQ1w a bond Me a bond NH O a bond Q3c OH 3327 CMe NH Q1w a bond H a bondNH S NH Q3a OH 3328 CMe NH Q1w a bond H a bond NH S NH Q3b OH 3329 CMeNH Q1w a bond H a bond NH S NH Q3c OH 3330 CMe NH Q1w a bond H a bond NHS a bond Q3a OH 3331 CMe NH Q1w a bond H a bond NH S a bond Q3b OH 3332CMe NH Q1w a bond H a bond NH S a bond Q3c OH 3333 CMe NH Q1w a bond H abond NH O NH Q3a OH 3334 CMe NH Q1w a bond H a bond NH O NH Q3b OH 3335CMe NH Q1w a bond H a bond NH O NH Q3c OH 3336 CMe NH Q1w a bond H abond NH O a bond Q3a OH 3337 CMe NH Q1w a bond H a bond NH O a bond Q3bOH 3338 CMe NH Q1w a bond H a bond NH O a bond Q3c OH 3339 CMe NH Q1x abond Me a bond NH S NH Q3a OH 3340 CMe NH Q1x a bond Me a bond NH S NHQ3b OH 3341 CMe NH Q1x a bond Me a bond NH S NH Q3c OH 3342 CMe NH Q1x abond Me a bond NH S a bond Q3a OH 3343 CMe NH Q1x a bond Me a bond NH Sa bond Q3b OH 3344 CMe NH Q1x a bond Me a bond NH S a bond Q3c OH 3345CMe NH Q1x a bond Me a bond NH O NH Q3a OH 3346 CMe NH Q1x a bond Me abond NH O NH Q3b OH 3347 CMe NH Q1x a bond Me a bond NH O NH Q3c OH 3348CMe NH Q1x a bond Me a bond NH O a bond Q3a OH 3349 CMe NH Q1x a bond Mea bond NH O a bond Q3b OH 3350 CMe NH Q1x a bond Me a bond NH O a bondQ3c OH 3351 CMe NH Q1x a bond H a bond NH S NH Q3a OH 3352 CMe NH Q1x abond H a bond NH S NH Q3b OH 3353 CMe NH Q1x a bond H a bond NH S NH Q3cOH 3354 CMe NH Q1x a bond H a bond NH S a bond Q3a OH 3355 CMe NH Q1x abond H a bond NH S a bond Q3b OH 3356 CMe NH Q1x a bond H a bond NH S abond Q3c OH 3357 CMe NH Q1x a bond H a bond NH O NH Q3a OH 3358 CMe NHQ1x a bond H a bond NH O NH Q3b OH 3359 CMe NH Q1x a bond H a bond NH ONH Q3c OH 3360 CMe NH Q1x a bond H a bond NH O a bond Q3a OH 3361 CMe NHQ1x a bond H a bond NH O a bond Q3b OH 3362 CMe NH Q1x a bond H a bondNH O a bond Q3c OH

70) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X areany of the following combinations in Table 3, tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.The symbols in Table 3 denote the flowing substituents.

TABLE 3 No A B R¹ L¹ R² L² L³ Y L⁴ R³ X 1 N NMe Q1a NH Me a bond NH S NHQ3a OH 2 N NMe Q1a NH Me a bond NH S a bond Q3a OH 3 N NMe Q1a NH Me abond NH O NH Q3a OH 4 N NMe Q1a NH Me a bond NH O a bond Q3a OH 5 N NMeQ1a NH H a bond NH S NH Q3a OH 6 N NMe Q1a NH H a bond NH S a bond Q3aOH 7 N NMe Q1a NH H a bond NH O NH Q3a OH 8 N NMe Q1a NH H a bond NH O abond Q3a OH 9 N NMe Q1b NH Me a bond NH S NH Q3a OH 10 N NMe Q1b NH Me abond NH S a bond Q3a OH 11 N NMe Q1b NH Me a bond NH O NH Q3a OH 12 NNMe Q1b NH Me a bond NH O a bond Q3a OH 13 N NMe Q1b NH H a bond NH S NHQ3a OH 14 N NMe Q1b NH H a bond NH S a bond Q3a OH 15 N NMe Q1b NH H abond NH O NH Q3a OH 16 N NMe Q1b NH H a bond NH O a bond Q3a OH 17 N SQ1a NH Me a bond NH S NH Q3a OH 18 N S Q1a NH Me a bond NH S a bond Q3aOH 19 N S Q1a NH Me a bond NH O NH Q3a OH 20 N S Q1a NH Me a bond NH O abond Q3a OH 21 N S Q1a NH H a bond NH S NH Q3a OH 22 N S Q1a NH H a bondNH S a bond Q3a OH 23 N S Q1a NH H a bond NH O NH Q3a OH 24 N S Q1a NH Ha bond NH O a bond Q3a OH 25 N S Q1b NH Me a bond NH S NH Q3a OH 26 N SQ1b NH Me a bond NH S a bond Q3a OH 27 N S Q1b NH Me a bond NH O NH Q3aOH 28 N S Q1b NH Me a bond NH O a bond Q3a OH 29 N S Q1b NH H a bond NHS NH Q3a OH 30 N S Q1b NH H a bond NH S a bond Q3a OH 31 N S Q1b NH H abond NH O NH Q3a OH 32 N S Q1b NH H a bond NH O a bond Q3a OH 33 N O Q1aNH Me a bond NH S NH Q3a OH 34 N O Q1a NH Me a bond NH S a bond Q3a OH35 N O Q1a NH Me a bond NH O NH Q3a OH 36 N O Q1a NH Me a bond NH O abond Q3a OH 37 N O Q1a NH H a bond NH S NH Q3a OH 38 N O Q1a NH H a bondNH S a bond Q3a OH 39 N O Q1a NH H a bond NH O NH Q3a OH 40 N O Q1a NH Ha bond NH O a bond Q3a OH 41 N O Q1b NH Me a bond NH S NH Q3a OH 42 N OQ1b NH Me a bond NH S a bond Q3a OH 43 N O Q1b NH Me a bond NH O NH Q3aOH 44 N O Q1b NH Me a bond NH O a bond Q3a OH 45 N O Q1b NH H a bond NHS NH Q3a OH 46 N O Q1b NH H a bond NH S a bond Q3a OH 47 N O Q1b NH H abond NH O NH Q3a OH 48 N O Q1b NH H a bond NH O a bond Q3a OH 49 CH NMeQ1a NH Me a bond NH S NH Q3a OH 50 CH NMe Q1a NH Me a bond NH S a bondQ3a OH 51 CH NMe Q1a NH Me a bond NH O NH Q3a OH 52 CH NMe Q1a NH Me abond NH O a bond Q3a OH 53 CH NMe Q1a NH H a bond NH S NH Q3a OH 54 CHNMe Q1a NH H a bond NH S a bond Q3a OH 55 CH NMe Q1a NH H a bond NH O NHQ3a OH 56 CH NMe Q1a NH H a bond NH O a bond Q3a OH 57 CH NMe Q1b NH Mea bond NH S NH Q3a OH 58 CH NMe Q1b NH Me a bond NH S a bond Q3a OH 59CH NMe Q1b NH Me a bond NH O NH Q3a OH 60 CH NMe Q1b NH Me a bond NH O abond Q3a OH 61 CH NMe Q1b NH H a bond NH S NH Q3a OH 62 CH NMe Q1b NH Ha bond NH S a bond Q3a OH 63 CH NMe Q1b NH H a bond NH O NH Q3a OH 64 CHNMe Q1b NH H a bond NH O a bond Q3a OH 65 CH S Q1a NH Me a bond NH S NHQ3a OH 66 CH S Q1a NH Me a bond NH S a bond Q3a OH 67 CH S Q1a NH Me abond NH O NH Q3a OH 68 CH S Q1a NH Me a bond NH O a bond Q3a OH 69 CH SQ1a NH H a bond NH S NH Q3a OH 70 CH S Q1a NH H a bond NH S a bond Q3aOH 71 CH S Q1a NH H a bond NH O NH Q3a OH 72 CH S Q1a NH H a bond NH O abond Q3a OH 73 CH S Q1b NH Me a bond NH S NH Q3a OH 74 CH S Q1b NH Me abond NH S a bond Q3a OH 75 CH S Q1b NH Me a bond NH O NH Q3a OH 76 CH SQ1b NH Me a bond NH O a bond Q3a OH 77 CH S Q1b NH H a bond NH S NH Q3aOH 78 CH S Q1b NH H a bond NH S a bond Q3a OH 79 CH S Q1b NH H a bond NHO NH Q3a OH 80 CH S Q1b NH H a bond NH O a bond Q3a OH 81 CH O Q1a NH Mea bond NH S NH Q3a OH 82 CH O Q1a NH Me a bond NH S a bond Q3a OH 83 CHO Q1a NH Me a bond NH O NH Q3a OH 84 CH O Q1a NH Me a bond NH O a bondQ3a OH 85 CH O Q1a NH H a bond NH S NH Q3a OH 86 CH O Q1a NH H a bond NHS a bond Q3a OH 87 CH O Q1a NH H a bond NH O NH Q3a OH 88 CH O Q1a NH Ha bond NH O a bond Q3a OH 89 CH O Q1b NH Me a bond NH S NH Q3a OH 90 CHO Q1b NH Me a bond NH S a bond Q3a OH 91 CH O Q1b NH Me a bond NH O NHQ3a OH 92 CH O Q1b NH Me a bond NH O a bond Q3a OH 93 CH O Q1b NH H abond NH S NH Q3a OH 94 CH O Q1b NH H a bond NH S a bond Q3a OH 95 CH OQ1b NH H a bond NH O NH Q3a OH 96 CH O Q1b NH H a bond NH O a bond Q3aOH 97 CMe NMe Q1a NH Me a bond NH S NH Q3a OH 98 CMe NMe Q1a NH Me abond NH S a bond Q3a OH 99 CMe NMe Q1a NH Me a bond NH O NH Q3a OH 100CMe NMe Q1a NH Me a bond NH O a bond Q3a OH 101 CMe NMe Q1a NH H a bondNH S NH Q3a OH 102 CMe NMe Q1a NH H a bond NH S a bond Q3a OH 103 CMeNMe Q1a NH H a bond NH O NH Q3a OH 104 CMe NMe Q1a NH H a bond NH O abond Q3a OH 105 CMe NMe Q1b NH Me a bond NH S NH Q3a OH 106 CMe NMe Q1bNH Me a bond NH S a bond Q3a OH 107 CMe NMe Q1b NH Me a bond NH O NH Q3aOH 108 CMe NMe Q1b NH Me a bond NH O a bond Q3a OH 109 CMe NMe Q1b NH Ha bond NH S NH Q3a OH 110 CMe NMe Q1b NH H a bond NH S a bond Q3a OH 111CMe NMe Q1b NH H a bond NH O NH Q3a OH 112 CMe NMe Q1b NH H a bond NH Oa bond Q3a OH 113 CMe S Q1a NH Me a bond NH S NH Q3a OH 114 CMe S Q1a NHMe a bond NH S a bond Q3a OH 115 CMe S Q1a NH Me a bond NH O NH Q3a OH116 CMe S Q1a NH Me a bond NH O a bond Q3a OH 117 CMe S Q1a NH H a bondNH S NH Q3a OH 118 CMe S Q1a NH H a bond NH S a bond Q3a OH 119 CMe SQ1a NH H a bond NH O NH Q3a OH 120 CMe S Q1a NH H a bond NH O a bond Q3aOH 121 CMe S Q1b NH Me a bond NH S NH Q3a OH 122 CMe S Q1b NH Me a bondNH S a bond Q3a OH 123 CMe S Q1b NH Me a bond NH O NH Q3a OH 124 CMe SQ1b NH Me a bond NH O a bond Q3a OH 125 CMe S Q1b NH H a bond NH S NHQ3a OH 126 CMe S Q1b NH H a bond NH S a bond Q3a OH 127 CMe S Q1b NH H abond NH O NH Q3a OH 128 CMe S Q1b NH H a bond NH O a bond Q3a OH 129 CMeO Q1a NH Me a bond NH S NH Q3a OH 130 CMe O Q1a NH Me a bond NH S a bondQ3a OH 131 CMe O Q1a NH Me a bond NH O NH Q3a OH 132 CMe O Q1a NH Me abond NH O a bond Q3a OH 133 CMe O Q1a NH H a bond NH S NH Q3a OH 134 CMeO Q1a NH H a bond NH S a bond Q3a OH 135 CMe O Q1a NH H a bond NH O NHQ3a OH 136 CMe O Q1a NH H a bond NH O a bond Q3a OH 137 CMe O Q1b NH Mea bond NH S NH Q3a OH 138 CMe O Q1b NH Me a bond NH S a bond Q3a OH 139CMe O Q1b NH Me a bond NH O NH Q3a OH 140 CMe O Q1b NH Me a bond NH O abond Q3a OH 141 CMe O Q1b NH H a bond NH S NH Q3a OH 142 CMe O Q1b NH Ha bond NH S a bond Q3a OH 143 CMe O Q1b NH H a bond NH O NH Q3a OH 144CMe O Q1b NH H a bond NH O a bond Q3a OH 145 N NMe Q1a O Me a bond NH SNH Q3a OH 146 N NMe Q1a O Me a bond NH S a bond Q3a OH 147 N NMe Q1a OMe a bond NH O NH Q3a OH 148 N NMe Q1a O Me a bond NH O a bond Q3a OH149 N NMe Q1a O H a bond NH S NH Q3a OH 150 N NMe Q1a O H a bond NH S abond Q3a OH 151 N NMe Q1a O H a bond NH O NH Q3a OH 152 N NMe Q1a O H abond NH O a bond Q3a OH 153 N NMe Q1b O Me a bond NH S NH Q3a OH 154 NNMe Q1b O Me a bond NH S a bond Q3a OH 155 N NMe Q1b O Me a bond NH O NHQ3a OH 156 N NMe Q1b O Me a bond NH O a bond Q3a OH 157 N NMe Q1b O H abond NH S NH Q3a OH 158 N NMe Q1b O H a bond NH S a bond Q3a OH 159 NNMe Q1b O H a bond NH O NH Q3a OH 160 N NMe Q1b O H a bond NH O a bondQ3a OH 161 N S Q1a O Me a bond NH S NH Q3a OH 162 N S Q1a O Me a bond NHS a bond Q3a OH 163 N S Q1a O Me a bond NH O NH Q3a OH 164 N S Q1a O Mea bond NH O a bond Q3a OH 165 N S Q1a O H a bond NH S NH Q3a OH 166 N SQ1a O H a bond NH S a bond Q3a OH 167 N S Q1a O H a bond NH O NH Q3a OH168 N S Q1a O H a bond NH O a bond Q3a OH 169 N S Q1b O Me a bond NH SNH Q3a OH 170 N S Q1b O Me a bond NH S a bond Q3a OH 171 N S Q1b O Me abond NH O NH Q3a OH 172 N S Q1b O Me a bond NH O a bond Q3a OH 173 N SQ1b O H a bond NH S NH Q3a OH 174 N S Q1b O H a bond NH S a bond Q3a OH175 N S Q1b O H a bond NH O NH Q3a OH 176 N S Q1b O H a bond NH O a bondQ3a OH 177 N O Q1a O Me a bond NH S NH Q3a OH 178 N O Q1a O Me a bond NHS a bond Q3a OH 179 N O Q1a O Me a bond NH O NH Q3a OH 180 N O Q1a O Mea bond NH O a bond Q3a OH 181 N O Q1a O H a bond NH S NH Q3a OH 182 N OQ1a O H a bond NH S a bond Q3a OH 183 N O Q1a O H a bond NH O NH Q3a OH184 N O Q1a O H a bond NH O a bond Q3a OH 185 N O Q1b O Me a bond NH SNH Q3a OH 186 N O Q1b O Me a bond NH S a bond Q3a OH 187 N O Q1b O Me abond NH O NH Q3a OH 188 N O Q1b O Me a bond NH O a bond Q3a OH 189 N OQ1b O H a bond NH S NH Q3a OH 190 N O Q1b O H a bond NH S a bond Q3a OH191 N O Q1b O H a bond NH O NH Q3a OH 192 N O Q1b O H a bond NH O a bondQ3a OH 193 CH NMe Q1a O Me a bond NH S NH Q3a OH 194 CH NMe Q1a O Me abond NH S a bond Q3a OH 195 CH NMe Q1a O Me a bond NH O NH Q3a OH 196 CHNMe Q1a O Me a bond NH O a bond Q3a OH 197 CH NMe Q1a O H a bond NH S NHQ3a OH 198 CH NMe Q1a O H a bond NH S a bond Q3a OH 199 CH NMe Q1a O H abond NH O NH Q3a OH 200 CH NMe Q1a O H a bond NH O a bond Q3a OH 201 CHNMe Q1b O Me a bond NH S NH Q3a OH 202 CH NMe Q1b O Me a bond NH S abond Q3a OH 203 CH NMe Q1b O Me a bond NH O NH Q3a OH 204 CH NMe Q1b OMe a bond NH O a bond Q3a OH 205 CH NMe Q1b O H a bond NH S NH Q3a OH206 CH NMe Q1b O H a bond NH S a bond Q3a OH 207 CH NMe Q1b O H a bondNH O NH Q3a OH 208 CH NMe Q1b O H a bond NH O a bond Q3a OH 209 CH S Q1aO Me a bond NH S NH Q3a OH 210 CH S Q1a O Me a bond NH S a bond Q3a OH211 CH S Q1a O Me a bond NH O NH Q3a OH 212 CH S Q1a O Me a bond NH O abond Q3a OH 213 CH S Q1a O H a bond NH S NH Q3a OH 214 CH S Q1a O H abond NH S a bond Q3a OH 215 CH S Q1a O H a bond NH O NH Q3a OH 216 CH SQ1a O H a bond NH O a bond Q3a OH 217 CH S Q1b O Me a bond NH S NH Q3aOH 218 CH S Q1b O Me a bond NH S a bond Q3a OH 219 CH S Q1b O Me a bondNH O NH Q3a OH 220 CH S Q1b O Me a bond NH O a bond Q3a OH 221 CH S Q1bO H a bond NH S NH Q3a OH 222 CH S Q1b O H a bond NH S a bond Q3a OH 223CH S Q1b O H a bond NH O NH Q3a OH 224 CH S Q1b O H a bond NH O a bondQ3a OH 225 CH O Q1a O Me a bond NH S NH Q3a OH 226 CH O Q1a O Me a bondNH S a bond Q3a OH 227 CH O Q1a O Me a bond NH O NH Q3a OH 228 CH O Q1aO Me a bond NH O a bond Q3a OH 229 CH O Q1a O H a bond NH S NH Q3a OH230 CH O Q1a O H a bond NH S a bond Q3a OH 231 CH O Q1a O H a bond NH ONH Q3a OH 232 CH O Q1a O H a bond NH O a bond Q3a OH 233 CH O Q1b O Me abond NH S NH Q3a OH 234 CH O Q1b O Me a bond NH S a bond Q3a OH 235 CH OQ1b O Me a bond NH O NH Q3a OH 236 CH O Q1b O Me a bond NH O a bond Q3aOH 237 CH O Q1b O H a bond NH S NH Q3a OH 238 CH O Q1b O H a bond NH S abond Q3a OH 239 CH O Q1b O H a bond NH O NH Q3a OH 240 CH O Q1b O H abond NH O a bond Q3a OH 241 CMe NMe Q1a O Me a bond NH S NH Q3a OH 242CMe NMe Q1a O Me a bond NH S a bond Q3a OH 243 CMe NMe Q1a O Me a bondNH O NH Q3a OH 244 CMe NMe Q1a O Me a bond NH O a bond Q3a OH 245 CMeNMe Q1a O H a bond NH S NH Q3a OH 246 CMe NMe Q1a O H a bond NH S a bondQ3a OH 247 CMe NMe Q1a O H a bond NH O NH Q3a OH 248 CMe NMe Q1a O H abond NH O a bond Q3a OH 249 CMe NMe Q1b O Me a bond NH S NH Q3a OH 250CMe NMe Q1b O Me a bond NH S a bond Q3a OH 251 CMe NMe Q1b O Me a bondNH O NH Q3a OH 252 CMe NMe Q1b O Me a bond NH O a bond Q3a OH 253 CMeNMe Q1b O H a bond NH S NH Q3a OH 254 CMe NMe Q1b O H a bond NH S a bondQ3a OH 255 CMe NMe Q1b O H a bond NH O NH Q3a OH 256 CMe NMe Q1b O H abond NH O a bond Q3a OH 257 CMe S Q1a O Me a bond NH S NH Q3a OH 258 CMeS Q1a O Me a bond NH S a bond Q3a OH 259 CMe S Q1a O Me a bond NH O NHQ3a OH 260 CMe S Q1a O Me a bond NH O a bond Q3a OH 261 CMe S Q1a O H abond NH S NH Q3a OH 262 CMe S Q1a O H a bond NH S a bond Q3a OH 263 CMeS Q1a O H a bond NH O NH Q3a OH 264 CMe S Q1a O H a bond NH O a bond Q3aOH 265 CMe S Q1b O Me a bond NH S NH Q3a OH 266 CMe S Q1b O Me a bond NHS a bond Q3a OH 267 CMe S Q1b O Me a bond NH O NH Q3a OH 268 CMe S Q1b OMe a bond NH O a bond Q3a OH 269 CMe S Q1b O H a bond NH S NH Q3a OH 270CMe S Q1b O H a bond NH S a bond Q3a OH 271 CMe S Q1b O H a bond NH O NHQ3a OH 272 CMe S Q1b O H a bond NH O a bond Q3a OH 273 CMe O Q1a O Me abond NH S NH Q3a OH 274 CMe O Q1a O Me a bond NH S a bond Q3a OH 275 CMeO Q1a O Me a bond NH O NH Q3a OH 276 CMe O Q1a O Me a bond NH O a bondQ3a OH 277 CMe O Q1a O H a bond NH S NH Q3a OH 278 CMe O Q1a O H a bondNH S a bond Q3a OH 279 CMe O Q1a O H a bond NH O NH Q3a OH 280 CMe O Q1aO H a bond NH O a bond Q3a OH 281 CMe O Q1b O Me a bond NH S NH Q3a OH282 CMe O Q1b O Me a bond NH S a bond Q3a OH 283 CMe O Q1b O Me a bondNH O NH Q3a OH 284 CMe O Q1b O Me a bond NH O a bond Q3a OH 285 CMe OQ1b O H a bond NH S NH Q3a OH 286 CMe O Q1b O H a bond NH S a bond Q3aOH 287 CMe O Q1b O H a bond NH O NH Q3a OH 288 CMe O Q1b O H a bond NH Oa bond Q3a OH 289 N NMe Q1a CH2 Me a bond NH S NH Q3a OH 290 N NMe Q1aCH2 Me a bond NH S a bond Q3a OH 291 N NMe Q1a CH2 Me a bond NH O NH Q3aOH 292 N NMe Q1a CH2 Me a bond NH O a bond Q3a OH 293 N NMe Q1a CH2 H abond NH S NH Q3a OH 294 N NMe Q1a CH2 H a bond NH S a bond Q3a OH 295 NNMe Q1a CH2 H a bond NH O NH Q3a OH 296 N NMe Q1a CH2 H a bond NH O abond Q3a OH 297 N NMe Q1b CH2 Me a bond NH S NH Q3a OH 298 N NMe Q1b CH2Me a bond NH S a bond Q3a OH 299 N NMe Q1b CH2 Me a bond NH O NH Q3a OH300 N NMe Q1b CH2 Me a bond NH O a bond Q3a OH 301 N NMe Q1b CH2 H abond NH S NH Q3a OH 302 N NMe Q1b CH2 H a bond NH S a bond Q3a OH 303 NNMe Q1b CH2 H a bond NH O NH Q3a OH 304 N NMe Q1b CH2 H a bond NH O abond Q3a OH 305 N S Q1a CH2 Me a bond NH S NH Q3a OH 306 N S Q1a CH2 Mea bond NH S a bond Q3a OH 307 N S Q1a CH2 Me a bond NH O NH Q3a OH 308 NS Q1a CH2 Me a bond NH O a bond Q3a OH 309 N S Q1a CH2 H a bond NH S NHQ3a OH 310 N S Q1a CH2 H a bond NH S a bond Q3a OH 311 N S Q1a CH2 H abond NH O NH Q3a OH 312 N S Q1a CH2 H a bond NH O a bond Q3a OH 313 N SQ1b CH2 Me a bond NH S NH Q3a OH 314 N S Q1b CH2 Me a bond NH S a bondQ3a OH 315 N S Q1b CH2 Me a bond NH O NH Q3a OH 316 N S Q1b CH2 Me abond NH O a bond Q3a OH 317 N S Q1b CH2 H a bond NH S NH Q3a OH 318 N SQ1b CH2 H a bond NH S a bond Q3a OH 319 N S Q1b CH2 H a bond NH O NH Q3aOH 320 N S Q1b CH2 H a bond NH O a bond Q3a OH 321 N O Q1a CH2 Me a bondNH S NH Q3a OH 322 N O Q1a CH2 Me a bond NH S a bond Q3a OH 323 N O Q1aCH2 Me a bond NH O NH Q3a OH 324 N O Q1a CH2 Me a bond NH O a bond Q3aOH 325 N O Q1a CH2 H a bond NH S NH Q3a OH 326 N O Q1a CH2 H a bond NH Sa bond Q3a OH 327 N O Q1a CH2 H a bond NH O NH Q3a OH 328 N O Q1a CH2 Ha bond NH O a bond Q3a OH 329 N O Q1b CH2 Me a bond NH S NH Q3a OH 330 NO Q1b CH2 Me a bond NH S a bond Q3a OH 331 N O Q1b CH2 Me a bond NH O NHQ3a OH 332 N O Q1b CH2 Me a bond NH O a bond Q3a OH 333 N O Q1b CH2 H abond NH S NH Q3a OH 334 N O Q1b CH2 H a bond NH S a bond Q3a OH 335 N OQ1b CH2 H a bond NH O NH Q3a OH 336 N O Q1b CH2 H a bond NH O a bond Q3aOH 337 CH NMe Q1a CH2 Me a bond NH S NH Q3a OH 338 CH NMe Q1a CH2 Me abond NH S a bond Q3a OH 339 CH NMe Q1a CH2 Me a bond NH O NH Q3 OH 340CH NMe Q1a CH2 Me a bond NH O a bond Q3a OH 341 CH NMe Q1a CH2 H a bondNH S NH Q3a OH 342 CH NMe Q1a CH2 H a bond NH S a bond Q3a OH 343 CH NMeQ1a CH2 H a bond NH O NH Q3a OH 344 CH NMe Q1a CH2 H a bond NH O a bond3a OH 345 CH NMe Q1b CH2 Me a bond NH S NH Q3a OH 346 CH NMe Q1b CH2 Mea bond NH S a bond Q3a OH 347 CH NMe Q1b CH2 Me a bond NH O NH Q3a OH348 CH NMe Q1b CH2 Me a bond NH O a bond Q3a OH 349 CH NMe Q1b CH2 H abond NH S NH Q3a OH 350 CH NMe Q1b CH2 H a bond NH S a bond Q3a OH 351CH NMe Q1b CH2 H a bond NH O NH Q3a OH 352 CH NMe Q1b CH2 H a bond NH Oa bond Q3a OH 353 CH S Q1a CH2 Me a bond NH S NH Q3a OH 354 CH S Q1a CH2Me a bond NH S a bond Q3a OH 355 CH S Q1a CH2 Me a bond NH O NH Q3a OH356 CH S Q1a CH2 Me a bond NH O a bond Q3a OH 357 CH S Q1a CH2 H a bondNH S NH Q3a OH 358 CH S Q1a CH2 H a bond NH S a bond Q3a OH 359 CH S Q1aCH2 H a bond NH O NH Q3a OH 360 CH S Q1a CH2 H a bond NH O a bond Q3a OH361 CH S Q1b CH2 Me a bond NH S NH Q3a OH 362 CH S Q1b CH2 Me a bond NHS a bond Q3a OH 363 CH S Q1b CH2 Me a bond NH O NH Q3a OH 364 CH S Q1bCH2 Me a bond NH O a bond Q3a OH 365 CH S Q1b CH2 H a bond NH S NH Q3aOH 366 CH S Q1b CH2 H a bond NH S a bond Q3a OH 367 CH S Q1b CH2 H abond NH O NH Q3a OH 368 CH S Q1b CH2 H a bond NH O a bond Q3a OH 369 CHO Q1a CH2 Me a bond NH S NH Q3a OH 370 CH O Q1a CH2 Me a bond NH S abond Q3a OH 371 CH O Q1a CH2 Me a bond NH O NH Q3a OH 372 CH O Q1a CH2Me a bond NH O a bond Q3a OH 373 CH O Q1a CH2 H a bond NH S NH Q3a OH374 CH O Q1a CH2 H a bond NH S a bond Q3a OH 375 CH O Q1a CH2 H a bondNH O NH Q3a OH 376 CH O Q1a CH2 H a bond NH O a bond Q3a OH 377 CH O Q1bCH2 Me a bond NH S NH Q3a OH 378 CH O Q1b CH2 Me a bond NH S a bond Q3aOH 379 CH O Q1b CH2 Me a bond NH O NH Q3a OH 380 CH O Q1b CH2 Me a bondNH O a bond Q3a OH 381 CH O Q1b CH2 H a bond NH S NH Q3a OH 382 CH O Q1bCH2 H a bond NH S a bond Q3a OH 383 CH O Q1b CH2 H a bond NH O NH Q3a OH384 CH O Q1b CH2 H a bond NH O a bond Q3a OH 385 CMe NMe Q1a CH2 Me abond NH S NH Q3a OH 386 CMe NMe Q1a CH2 Me a bond NH S a bond Q3a OH 387CMe NMe Q1a CH2 Me a bond NH O NH Q3a OH 388 CMe NMe Q1a CH2 Me a bondNH O a bond Q3a OH 389 CMe NMe Q1a CH2 H a bond NH S NH Q3a OH 390 CMeNMe Q1a CH2 H a bond NH S a bond Q3a OH 391 CMe NMe Q1a CH2 H a bond NHO NH Q3a OH 392 CMe NMe Q1a CH2 H a bond NH O a bond Q3a OH 393 CMe NMeQ1b CH2 Me a bond NH S NH Q3a OH 394 CMe NMe Q1b CH2 Me a bond NH S abond Q3a OH 395 CMe NMe Q1b CH2 Me a bond NH O NH Q3a OH 396 CMe NMe Q1bCH2 Me a bond NH O a bond Q3a OH 397 CMe NMe Q1b CH2 H a bond NH S NHQ3a OH 398 CMe NMe Q1b CH2 H a bond NH S a bond Q3a OH 399 CMe NMe Q1bCH2 H a bond NH O NH Q3a OH 400 CMe NMe Q1b CH2 H a bond NH O a bond Q3aOH 401 CMe S Q1a CH2 Me a bond NH S NH Q3a OH 402 CMe S Q1a CH2 Me abond NH S a bond Q3a OH 403 CMe S Q1a CH2 Me a bond NH O NH Q3a OH 404CMe S Q1a CH2 Me a bond NH O a bond Q3a OH 405 CMe S Q1a CH2 H a bond NHS NH Q3a OH 406 CMe S Q1a CH2 H a bond NH S a bond Q3a OH 407 CMe S Q1aCH2 H a bond NH O NH Q3a OH 408 CMe S Q1a CH2 H a bond NH O a bond Q3aOH 409 CMe S Q1b CH2 Me a bond NH S NH Q3a OH 410 CMe S Q1b CH2 Me abond NH S a bond Q3a OH 411 CMe S Q1b CH2 Me a bond NH O NH Q3a OH 412CMe S Q1b CH2 Me a bond NH O a bond Q3a OH 413 CMe S Q1b CH2 H a bond NHS NH Q3a OH 414 CMe S Q1b CH2 H a bond NH S a bond Q3a OH 415 CMe S Q1bCH2 H a bond NH O NH Q3a OH 416 CMe S Q1b CH2 H a bond NH O a bond Q3aOH 417 CMe O Q1a CH2 Me a bond NH S NH Q3a OH 418 CMe O Q1a CH2 Me abond NH S a bond Q3a OH 419 CMe O Q1a CH2 Me a bond NH O NH Q3a OH 420CMe O Q1a CH2 Me a bond NH O a bond Q3a OH 421 CMe O Q1a CH2 H a bond NHS NH Q3a OH 422 CMe O Q1a CH2 H a bond NH S a bond Q3a OH 423 CMe O Q1aCH2 H a bond NH O NH Q3a OH 424 CMe O Q1a CH2 H a bond NH O a bond Q3aOH 425 CMe O Q1b CH2 Me a bond NH S NH Q3a OH 426 CMe O Q1b CH2 Me abond NH S a bond Q3a OH 427 CMe O Q1b CH2 Me a bond NH O NH Q3a OH 428CMe O Q1b CH2 Me a bond NH O a bond Q3a OH 429 CMe O Q1b CH2 H a bond NHS NH Q3a OH 430 CMe O Q1b CH2 H a bond NH S a bond Q3a OH 431 CMe O Q1bCH2 H a bond NH O NH Q3a OH 432 CMe O Q1b CH2 H a bond NH O a bond Q3aOH 433 N NMe Q1a a bond Me a bond NH S CH2 Q3a OH 434 N NMe Q1a a bondMe a bond NH O CH2 Q3a OH 435 N NMe Q1a a bond H a bond NH S CH2 Q3a OH436 N NMe Q1a a bond H a bond NH O CH2 Q3a OH 437 N NMe Q1b a bond Me abond NH S CH2 Q3a OH 438 N NMe Q1b a bond Me a bond NH O CH2 Q3a OH 439N NMe Q1b a bond H a bond NH S CH2 Q3a OH 440 N NMe Q1b a bond H a bondNH O CH2 Q3a OH 441 N S Q1a a bond Me a bond NH S CH2 Q3a OH 442 N S Q1aa bond Me a bond NH O CH2 Q3a OH 443 N S Q1a a bond H a bond NH S CH2Q3a OH 444 N S Q1a a bond H a bond NH O CH2 Q3a OH 445 N S Q1b a bond Mea bond NH S CH2 Q3a OH 446 N S Q1b a bond Me a bond NH O CH2 Q3a OH 447N S Q1b a bond H a bond NH S CH2 Q3a OH 448 N S Q1b a bond H a bond NH OCH2 Q3a OH 449 N O Q1a a bond Me a bond NH S CH2 Q3a OH 450 N O Q1a abond Me a bond NH O CH2 Q3a OH 451 N O Q1a a bond H a bond NH S CH2 Q3aOH 452 N O Q1a a bond H a bond NH O CH2 Q3a OH 453 N O Q1b a bond Me abond NH S CH2 Q3a OH 454 N O Q1b a bond Me a bond NH O CH2 Q3a OH 455 NO Q1b a bond H a bond NH S CH2 Q3a OH 456 N O Q1b a bond H a bond NH OCH2 Q3a OH 457 CH NMe Q1a a bond Me a bond NH S CH2 Q3a OH 458 CH NMeQ1a a bond Me a bond NH O CH2 Q3a OH 459 CH NMe Q1a a bond H a bond NH SCH2 Q3a OH 460 CH NMe Q1a a bond H a bond NH O CH2 Q3a OH 461 CH NMe Q1ba bond Me a bond NH S CH2 Q3a OH 462 CH NMe Q1b a bond Me a bond NH OCH2 Q3a OH 463 CH NMe Q1b a bond H a bond NH S CH2 Q3a OH 464 CH NMe Q1ba bond H a bond NH O CH2 Q3a OH 465 CH S Q1a a bond Me a bond NH S CH2Q3a OH 466 CH S Q1a a bond Me a bond NH O CH2 Q3a OH 467 CH S Q1a a bondH a bond NH S CH2 Q3a OH 468 CH S Q1a a bond H a bond NH O CH2 Q3a OH469 CH S Q1b a bond Me a bond NH S CH2 Q3a OH 470 CH S Q1b a bond Me abond NH O CH2 Q3a OH 471 CH S Q1b a bond H a bond NH S CH2 Q3a OH 472 CHS Q1b a bond H a bond NH O CH2 Q3a OH 473 CH O Q1a a bond Me a bond NH SCH2 Q3a OH 474 CH O Q1a a bond Me a bond NH O CH2 Q3a OH 475 CH O Q1a abond H a bond NH S CH2 Q3a OH 476 CH O Q1a a bond H a bond NH O CH2 Q3aOH 477 CH O Q1b a bond Me a bond NH S CH2 Q3a OH 478 CH O Q1b a bond Mea bond NH O CH2 Q3a OH 479 CH O Q1b a bond H a bond NH S CH2 Q3a OH 480CH O Q1b a bond H a bond NH O CH2 Q3a OH 481 CMe NMe Q1a a bond Me abond NH S CH2 Q3a OH 482 CMe NMe Q1a a bond Me a bond NH O CH2 Q3a OH483 CMe NMe Q1a a bond H a bond NH S CH2 Q3a OH 484 CMe NMe Q1a a bond Ha bond NH O CH2 Q3a OH 485 CMe NMe Q1b a bond Me a bond NH S CH2 Q3a OH486 CMe NMe Q1b a bond Me a bond NH O CH2 Q3a OH 487 CMe NMe Q1b a bondH a bond NH S CH2 Q3a OH 488 CMe NMe Q1b a bond H a bond NH O CH2 Q3a OH489 CMe S Q1a a bond Me a bond NH S CH2 Q3a OH 490 CMe S Q1a a bond Me abond NH O CH2 Q3a OH 491 CMe S Q1a a bond H a bond NH S CH2 Q3a OH 492CMe S Q1a a bond H a bond NH O CH2 Q3a OH 493 CMe S Q1b a bond Me a bondNH S CH2 Q3a OH 494 CMe S Q1b a bond Me a bond NH O CH2 Q3a OH 495 CMe SQ1b a bond H a bond NH S CH2 Q3a OH 496 CMe S Q1b a bond H a bond NH OCH2 Q3a OH 497 CMe O Q1a a bond Me a bond NH S CH2 Q3a OH 498 CMe O Q1aa bond Me a bond NH O CH2 Q3a OH 499 CMe O Q1a a bond H a bond NH S CH2Q3a OH 500 CMe O Q1a a bond H a bond NH O CH2 Q3a OH 501 CMe O Q1b abond Me a bond NH S CH2 Q3a OH 502 CMe O Q1b a bond Me a bond NH O CH2Q3a OH 503 CMe O Q1b a bond H a bond NH S CH2 Q3a OH 504 CMe O Q1b abond H a bond NH O CH2 Q3a OH 505 N NMe Q1a a bond Me a bond CH2 S abond Q3a OH 506 N NMe Q1a a bond Me a bond CH2 S NH Q3a OH 507 N NMe Q1aa bond Me a bond CH2 O a bond Q3a OH 508 N NMe Q1a a bond Me a bond CH2O NH Q3a OH 509 N NMe Q1a a bond H a bond CH2 S a bond Q3a OH 510 N NMeQ1a a bond H a bond CH2 S NH Q3a OH 511 N NMe Q1a a bond H a bond CH2 Oa bond Q3a OH 512 N NMe Q1a a bond H a bond CH2 O NH Q3a OH 513 N NMeQ1b a bond Me a bond CH2 S a bond Q3a OH 514 N NMe Q1b a bond Me a bondCH2 S NH Q3a OH 515 N NMe Q1b a bond Me a bond CH2 O a bond Q3a OH 516 NNMe Q1b a bond Me a bond CH2 O NH Q3a OH 517 N NMe Q1b a bond H a bondCH2 S a bond Q3a OH 518 N NMe Q1b a bond H a bond CH2 S NH Q3a OH 519 NNMe Q1b a bond H a bond CH2 O a bond Q3a OH 520 N NMe Q1b a bond H abond CH2 O NH Q3a OH 521 N S Q1a a bond Me a bond CH2 S a bond Q3a OH522 N S Q1a a bond Me a bond CH2 S NH Q3a OH 523 N S Q1a a bond Me abond CH2 O a bond Q3a OH 524 N S Q1a a bond Me a bond CH2 O NH Q3a OH525 N S Q1a a bond H a bond CH2 S a bond Q3a OH 526 N S Q1a a bond H abond CH2 S NH Q3a OH 527 N S Q1a a bond H a bond CH2 O a bond Q3a OH 528N S Q1a a bond H a bond CH2 O NH Q3a OH 529 N S Q1b a bond Me a bond CH2S a bond Q3a OH 530 N S Q1b a bond Me a bond CH2 S NH Q3a OH 531 N S Q1ba bond Me a bond CH2 O a bond Q3a OH 532 N S Q1b a bond Me a bond CH2 ONH Q3a OH 533 N S Q1b a bond H a bond CH2 S a bond Q3a OH 534 N S Q1b abond H a bond CH2 S NH Q3a OH 535 N S Q1b a bond H a bond CH2 O a bondQ3a OH 536 N S Q1b a bond H a bond CH2 O NH Q3a OH 537 N O Q1a a bond Mea bond CH2 S a bond Q3a OH 538 N O Q1a a bond Me a bond CH2 S NH Q3a OH539 N O Q1a a bond Me a bond CH2 O a bond Q3a OH 540 N O Q1a a bond Me abond CH2 O NH Q3a OH 541 N O Q1a a bond H a bond CH2 S a bond Q3a OH 542N O Q1a a bond H a bond CH2 S NH Q3a OH 543 N O Q1a a bond H a bond CH2O a bond Q3a OH 544 N O Q1a a bond H a bond CH2 O NH Q3a OH 545 N O Q1ba bond Me a bond CH2 S a bond Q3a OH 546 N O Q1b a bond Me a bond CH2 SNH Q3a OH 547 N O Q1b a bond Me a bond CH2 O a bond Q3a OH 548 N O Q1b abond Me a bond CH2 O NH Q3a OH 549 N O Q1b a bond H a bond CH2 S a bondQ3a OH 550 N O Q1b a bond H a bond CH2 S NH Q3a OH 551 N O Q1b a bond Ha bond CH2 O a bond Q3a OH 552 N O Q1b a bond H a bond CH2 O NH Q3a OH553 CH NMe Q1a a bond Me a bond CH2 S a bond Q3a OH 554 CH NMe Q1a abond Me a bond CH2 S NH Q3a OH 555 CH NMe Q1a a bond Me a bond CH2 O abond Q3a OH 556 CH NMe Q1a a bond Me a bond CH2 O NH Q3a OH 557 CH NMeQ1a a bond H a bond CH2 S a bond Q3a OH 558 CH NMe Q1a a bond H a bondCH2 S NH Q3a OH 559 CH NMe Q1a a bond H a bond CH2 O a bond Q3a OH 560CH NMe Q1a a bond H a bond CH2 O NH Q3a OH 561 CH NMe Q1b a bond Me abond CH2 S a bond Q3a OH 562 CH NMe Q1b a bond Me a bond CH2 S NH Q3a OH563 CH NMe Q1b a bond Me a bond CH2 O a bond Q3a OH 564 CH NMe Q1b abond Me a bond CH2 O NH Q3a OH 565 CH NMe Q1b a bond H a bond CH2 S abond Q3a OH 566 CH NMe Q1b a bond H a bond CH2 S NH Q3a OH 567 CH NMeQ1b a bond H a bond CH2 O a bond Q3a OH 568 CH NMe Q1b a bond H a bondCH2 O NH Q3a OH 569 CH S Q1a a bond Me a bond CH2 S a bond Q3a OH 570 CHS Q1a a bond Me a bond CH2 S NH Q3a OH 571 CH S Q1a a bond Me a bond CH2O a bond Q3a OH 572 CH S Q1a a bond Me a bond CH2 O NH Q3a OH 573 CH SQ1a a bond H a bond CH2 S a bond Q3a OH 574 CH S Q1a a bond H a bond CH2S NH Q3a OH 575 CH S Q1a a bond H a bond CH2 O a bond Q3a OH 576 CH SQ1a a bond H a bond CH2 O NH Q3a OH 577 CH S Q1b a bond Me a bond CH2 Sa bond Q3a OH 578 CH S Q1b a bond Me a bond CH2 S NH Q3a OH 579 CH S Q1ba bond Me a bond CH2 O a bond Q3a OH 580 CH S Q1b a bond Me a bond CH2 ONH Q3a OH 581 CH S Q1b a bond H a bond CH2 S a bond Q3a OH 582 CH S Q1ba bond H a bond CH2 S NH Q3a OH 583 CH S Q1b a bond H a bond CH2 O abond Q3a OH 584 CH S Q1b a bond H a bond CH2 O NH Q3a OH 585 CH O Q1a abond Me a bond CH2 S a bond Q3a OH 586 CH O Q1a a bond Me a bond CH2 SNH Q3a OH 587 CH O Q1a a bond Me a bond CH2 O a bond Q3a OH 588 CH O Q1aa bond Me a bond CH2 O NH Q3a OH 589 CH O Q1a a bond H a bond CH2 S abond Q3a OH 590 CH O Q1a a bond H a bond CH2 S NH Q3a OH 591 CH O Q1a abond H a bond CH2 O a bond Q3a OH 592 CH O Q1a a bond H a bond CH2 O NHQ3a OH 593 CH O Q1b a bond Me a bond CH2 S a bond Q3a OH 594 CH O Q1b abond Me a bond CH2 S NH Q3a OH 595 CH O Q1b a bond Me a bond CH2 O abond Q3a OH 596 CH O Q1b a bond Me a bond CH2 O NH Q3a OH 597 CH O Q1b abond H a bond CH2 S a bond Q3a OH 598 CH O Q1b a bond H a bond CH2 S NHQ3a OH 599 CH O Q1b a bond H a bond CH2 O a bond Q3a OH 600 CH O Q1b abond H a bond CH2 O NH Q3a OH 601 CMe NMe Q1a a bond Me a bond CH2 S abond Q3a OH 602 CMe NMe Q1a a bond Me a bond CH2 S NH Q3a OH 603 CMe NMeQ1a a bond Me a bond CH2 O a bond Q3a OH 604 CMe NMe Q1a a bond Me abond CH2 O NH Q3a OH 605 CMe NMe Q1a a bond H a bond CH2 S a bond Q3a OH606 CMe NMe Q1a a bond H a bond CH2 S NH Q3a OH 607 CMe NMe Q1a a bond Ha bond CH2 O a bond Q3a OH 608 CMe NMe Q1a a bond H a bond CH2 O NH Q3aOH 609 CMe NMe Q1b a bond Me a bond CH2 S a bond Q3a OH 610 CMe NMe Q1ba bond Me a bond CH2 S NH Q3a OH 611 CMe NMe Q1b a bond Me a bond CH2 Oa bond Q3a OH 612 CMe NMe Q1b a bond Me a bond CH2 O NH Q3a OH 613 CMeNMe Q1b a bond H a bond CH2 S a bond Q3a OH 614 CMe NMe Q1b a bond H abond CH2 S NH Q3a OH 615 CMe NMe Q1b a bond H a bond CH2 O a bond Q3a OH616 CMe NMe Q1b a bond H a bond CH2 O NH Q3a OH 617 CMe S Q1a a bond Mea bond CH2 S a bond Q3a OH 618 CMe S Q1a a bond Me a bond CH2 S NH Q3aOH 619 CMe S Q1a a bond Me a bond CH2 O a bond Q3a OH 620 CMe S Q1a abond Me a bond CH2 O NH Q3a OH 621 CMe S Q1a a bond H a bond CH2 S abond Q3a OH 622 CMe S Q1a a bond H a bond CH2 S NH Q3a OH 623 CMe S Q1aa bond H a bond CH2 O a bond Q3a OH 624 CMe S Q1a a bond H a bond CH2 ONH Q3a OH 625 CMe S Q1b a bond Me a bond CH2 S a bond Q3a OH 626 CMe SQ1b a bond Me a bond CH2 S NH Q3a OH 627 CMe S Q1b a bond Me a bond CH2O a bond Q3a OH 628 CMe S Q1b a bond Me a bond CH2 O NH Q3a OH 629 CMe SQ1b a bond H a bond CH2 S a bond Q3a OH 630 CMe S Q1b a bond H a bondCH2 S NH Q3a OH 631 CMe S Q1b a bond H a bond CH2 O a bond Q3a OH 632CMe S Q1b a bond H a bond CH2 O NH Q3a OH 633 CMe O Q1a a bond Me a bondCH2 S a bond Q3a OH 634 CMe O Q1a a bond Me a bond CH2 S NH Q3a OH 635CMe O Q1a a bond Me a bond CH2 O a bond Q3a OH 636 CMe O Q1a a bond Me abond CH2 O NH Q3a OH 637 CMe O Q1a a bond H a bond CH2 S a bond Q3a OH638 CMe O Q1a a bond H a bond CH2 S NH Q3a OH 639 CMe O Q1a a bond H abond CH2 O a bond Q3a OH 640 CMe O Q1a a bond H a bond CH2 O NH Q3a OH641 CMe O Q1b a bond Me a bond CH2 S a bond Q3a OH 642 CMe O Q1b a bondMe a bond CH2 S NH Q3a OH 643 CMe O Q1b a bond Me a bond CH2 O a bondQ3a OH 644 CMe O Q1b a bond Me a bond CH2 O NH Q3a OH 645 CMe O Q1b abond H a bond CH2 S a bond Q3a OH 646 CMe O Q1b a bond H a bond CH2 S NHQ3a OH 647 CMe O Q1b a bond H a bond CH2 O a bond Q3a OH 648 CMe O Q1b abond H a bond CH2 O NH Q3a OH 649 CMe NH Q1a NH Me a bond NH S NH Q3a OH650 CMe NH Q1a NH Me a bond NH S a bond Q3a OH 651 CMe NH Q1a NH Me abond NH O NH Q3a OH 652 CMe NH Q1a NH Me a bond NH O a bond Q3a OH 653CMe NH Q1a NH H a bond NH S NH Q3a OH 654 CMe NH Q1a NH H a bond NH S abond Q3a OH 655 CMe NH Q1a NH H a bond NH O NH Q3a OH 656 CMe NH Q1a NHH a bond NH O a bond Q3a OH 657 CMe NH Q1b NH Me a bond NH S NH Q3a OH658 CMe NH Q1b NH Me a bond NH S a bond Q3a OH 659 CMe NH Q1b NH Me abond NH O NH Q3a OH 660 CMe NH Q1b NH Me a bond NH O a bond Q3a OH 661CMe NH Q1b NH H a bond NH S NH Q3a OH 662 CMe NH Q1b NH H a bond NH S abond Q3a OH 663 CMe NH Q1b NH H a bond NH O NH Q3a OH 664 CMe NH Q1b NHH a bond NH O a bond Q3a OH 665 CMe NH Q1a O Me a bond NH S NH Q3a OH666 CMe NH Q1a O Me a bond NH S a bond Q3a OH 667 CMe NH Q1a O Me a bondNH O NH Q3a OH 668 CMe NH Q1a O Me a bond NH O a bond Q3a OH 669 CMe NHQ1a O H a bond NH S NH Q3a OH 670 CMe NH Q1a O H a bond NH S a bond Q3aOH 671 CMe NH Q1a O H a bond NH O NH Q3a OH 672 CMe NH Q1a O H a bond NHO a bond Q3a OH 673 CMe NH Q1b O Me a bond NH S NH Q3a OH 674 CMe NH Q1bO Me a bond NH S a bond Q3a OH 675 CMe NH Q1b O Me a bond NH O NH Q3a OH676 CMe NH Q1b O Me a bond NH O a bond Q3a OH 677 CMe NH Q1b O H a bondNH S NH Q3a OH 678 CMe NH Q1b O H a bond NH S a bond Q3a OH 679 CMe NHQ1b O H a bond NH O NH Q3a OH 680 CMe NH Q1b O H a bond NH O a bond Q3aOH 681 CMe NH Q1a CH2 Me a bond NH S NH Q3a OH 682 CMe NH Q1a CH2 Me abond NH S a bond Q3a OH 683 CMe NH Q1a CH2 Me a bond NH O NH Q3a OH 684CMe NH Q1a CH2 Me a bond NH O a bond Q3a OH 685 CMe NH Q1a CH2 H a bondNH S NH Q3a OH 686 CMe NH Q1a CH2 H a bond NH S a bond Q3a OH 687 CMe NHQ1a CH2 H a bond NH O NH Q3a OH 688 CMe NH Q1a CH2 H a bond NH O a bondQ3a OH 689 CMe NH Q1b CH2 Me a bond NH S NH Q3a OH 690 CMe NH Q1b CH2 Mea bond NH S a bond Q3a OH 691 CMe NH Q1b CH2 Me a bond NH O NH Q3a OH692 CMe NH Q1b CH2 Me a bond NH O a bond Q3a OH 693 CMe NH Q1b CH2 H abond NH S NH Q3a OH 694 CMe NH Q1b CH2 H a bond NH S a bond Q3a OH 695CMe NH Q1b CH2 H a bond NH O NH Q3a OH 696 CMe NH Q1b CH2 H a bond NH Oa bond Q3a OH 697 CMe NH Q1a a bond Me a bond NH S CH2 Q3a OH 698 CMe NHQ1a a bond Me a bond NH O CH2 Q3a OH 699 CMe NH Q1a a bond H a bond NH SCH2 Q3a OH 700 CMe NH Q1a a bond H a bond NH O CH2 Q3a OH 701 CMe NH Q1ba bond Me a bond NH S CH2 Q3a OH 702 CMe NH Q1b a bond Me a bond NH OCH2 Q3a OH 703 CMe NH Q1b a bond H a bond NH S CH2 Q3a OH 704 CMe NH Q1ba bond H a bond NH O CH2 Q3a OH 705 CMe NH Q1a a bond Me a bond CH2 S abond Q3a OH 706 CMe NH Q1a a bond Me a bond CH2 S NH Q3a OH 707 CMe NHQ1a a bond Me a bond CH2 O a bond Q3a OH 708 CMe NH Q1a a bond Me a bondCH2 O NH Q3a OH 709 CMe NH Q1a a bond H a bond CH2 S a bond Q3a OH 710CMe NH Q1a a bond H a bond CH2 S NH Q3a OH 711 CMe NH Q1a a bond H abond CH2 O a bond Q3a OH 712 CMe NH Q1a a bond H a bond CH2 O NH Q3a OH713 CMe NH Q1b a bond Me a bond CH2 S a bond Q3a OH 714 CMe NH Q1b abond Me a bond CH2 S NH Q3a OH 715 CMe NH Q1b a bond Me a bond CH2 O abond Q3a OH 716 CMe NH Q1b a bond Me a bond CH2 O NH Q3a OH 717 CMe NHQ1b a bond H a bond CH2 S a bond Q3a OH 718 CMe NH Q1b a bond H a bondCH2 S NH Q3a OH 719 CMe NH Q1b a bond H a bond CH2 O a bond Q3a OH 720CMe NH Q1b a bond H a bond CH2 O NH Q3a OH

71) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X areany of the following combinations in Table 4, tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.The symbols in Table 4 denote the flowing substituents.

TABLE 4 No A B R¹ L¹ R² L² L³ Y L⁴ R³ X 1 N NMe Q1a a bond Me a bond NHS NH Q3i OH 2 N NMe Q1a a bond Me a bond NH S NH Q3j OH 3 N NMe Q1b abond Me a bond NH S NH Q3i OH 4 N NMe Q1b a bond Me a bond NH S NH Q3jOH 5 N NMe Q1c a bond Me a bond NH S NH Q3i OH 6 N NMe Q1c a bond Me abond NH S NH Q3j OH 7 N NEt Q1a a bond Me a bond NH S NH Q3i OH 8 N NEtQ1a a bond Me a bond NH S NH Q3j OH 9 N NEt Q1b a bond Me a bond NH S NHQ3i OH 10 N NEt Q1b a bond Me a bond NH S NH Q3j OH 11 N NEt Q1c a bondMe a bond NH S NH Q3i OH 12 N NEt Q1c a bond Me a bond NH S NH Q3j OH 13N S Q1a a bond Me a bond NH S NH Q3i OH 14 N S Q1a a bond Me a bond NH SNH Q3j OH 15 N S Q1b a bond Me a bond NH S NH Q3i OH 16 N S Q1b a bondMe a bond NH S NH Q3j OH 17 N S Q1c a bond Me a bond NH S NH Q3i OH 18 NS Q1c a bond Me a bond NH S NH Q3j OH 19 N O Q1a a bond Me a bond NH SNH Q3i OH 20 N O Q1a a bond Me a bond NH S NH Q3j OH 21 N O Q1b a bondMe a bond NH S NH Q3i OH 22 N O Q1b a bond Me a bond NH S NH Q3j OH 23 NO Q1c a bond Me a bond NH S NH Q3i OH 24 N O Q1c a bond Me a bond NH SNH Q3j OH 25 CH NMe Q1a a bond Me a bond NH S NH Q3i OH 26 CH NMe Q1a abond Me a bond NH S NH Q3j OH 27 CH NMe Q1b a bond Me a bond NH S NH Q3iOH 28 CH NMe Q1b a bond Me a bond NH S NH Q3j OH 29 CH NMe Q1c a bond Mea bond NH S NH Q3i OH 30 CH NMe Q1c a bond Me a bond NH S NH Q3j OH 31CH NEt Q1a a bond Me a bond NH S NH Q3i OH 32 CH NEt Q1a a bond Me abond NH S NH Q3j OH 33 CH NEt Q1b a bond Me a bond NH S NH Q3i OH 34 CHNEt Q1b a bond Me a bond NH S NH Q3j OH 35 CH NEt Q1c a bond Me a bondNH S NH Q3i OH 36 CH NEt Q1c a bond Me a bond NH S NH Q3j OH 37 CH S Q1aa bond Me a bond NH S NH Q3i OH 38 CH S Q1a a bond Me a bond NH S NH Q3jOH 39 CH S Q1b a bond Me a bond NH S NH Q3i OH 40 CH S Q1b a bond Me abond NH S NH Q3j OH 41 CH S Q1c a bond Me a bond NH S NH Q3i OH 42 CH SQ1c a bond Me a bond NH S NH Q3j OH 43 CH O Q1a a bond Me a bond NH S NHQ3i OH 44 CH O Q1a a bond Me a bond NH S NH Q3j OH 45 CH O Q1b a bond Mea bond NH S NH Q3i OH 46 CH O Q1b a bond Me a bond NH S NH Q3j OH 47 CHO Q1c a bond Me a bond NH S NH Q3i OH 48 CH O Q1c a bond Me a bond NH SNH Q3j OH 49 CMe NMe Q1a a bond Me a bond NH S NH Q3i OH 50 CMe NMe Q1aa bond Me a bond NH S NH Q3j OH 51 CMe NMe Q1b a bond Me a bond NH S NHQ3i OH 52 CMe NMe Q1b a bond Me a bond NH S NH Q3j OH 53 CMe NMe Q1c abond Me a bond NH S NH Q3i OH 54 CMe NMe Q1c a bond Me a bond NH S NHQ3j OH 55 CMe NEt Q1a a bond Me a bond NH S NH Q3i OH 56 CMe NEt Q1a abond Me a bond NH S NH Q3j OH 57 CMe NEt Q1b a bond Me a bond NH S NHQ3i OH 58 CMe NEt Q1b a bond Me a bond NH S NH Q3j OH 59 CMe NEt Q1c abond Me a bond NH S NH Q3i OH 60 CMe NEt Q1c a bond Me a bond NH S NHQ3j OH 61 CMe S Q1a a bond Me a bond NH S NH Q3i OH 62 CMe S Q1a a bondMe a bond NH S NH Q3j OH 63 CMe S Q1b a bond Me a bond NH S NH Q3i OH 64CMe S Q1b a bond Me a bond NH S NH Q3j OH 65 CMe S Q1c a bond Me a bondNH S NH Q3i OH 66 CMe S Q1c a bond Me a bond NH S NH Q3j OH 67 CMe O Q1aa bond Me a bond NH S NH Q3i OH 68 CMe O Q1a a bond Me a bond NH S NHQ3j OH 69 CMe O Q1b a bond Me a bond NH S NH Q3i OH 70 CMe O Q1b a bondMe a bond NH S NH Q3j OH 71 CMe O Q1c a bond Me a bond NH S NH Q3i OH 72CMe O Q1c a bond Me a bond NH S NH Q3j OH 73 N NMe Q1a a bond Me a bondNH O a bond Q3i OH 74 N NMe Q1a a bond Me a bond NH O a bond Q3j OH 75 NNMe Q1b a bond Me a bond NH O a bond Q3i OH 76 N NMe Q1b a bond Me abond NH O a bond Q3j OH 77 N NMe Q1c a bond Me a bond NH O a bond Q3i OH78 N NMe Q1c a bond Me a bond NH O a bond Q3j OH 79 N NEt Q1a a bond Mea bond NH O a bond Q3i OH 80 N NEt Q1a a bond Me a bond NH O a bond Q3jOH 81 N NEt Q1b a bond Me a bond NH O a bond Q3i OH 82 N NEt Q1b a bondMe a bond NH O a bond Q3j OH 83 N NEt Q1c a bond Me a bond NH O a bondQ3i OH 84 N NEt Q1c a bond Me a bond NH O a bond Q3j OH 85 N S Q1a abond Me a bond NH O a bond Q3i OH 86 N S Q1a a bond Me a bond NH O abond Q3j OH 87 N S Q1b a bond Me a bond NH O a bond Q3i OH 88 N S Q1b abond Me a bond NH O a bond Q3j OH 89 N S Q1c a bond Me a bond NH O abond Q3i OH 90 N S Q1c a bond Me a bond NH O a bond Q3j OH 91 N O Q1a abond Me a bond NH O a bond Q3i OH 92 N O Q1a a bond Me a bond NH O abond Q3j OH 93 N O Q1b a bond Me a bond NH O a bond Q3i OH 94 N O Q1b abond Me a bond NH O a bond Q3j OH 95 N O Q1c a bond Me a bond NH O abond Q3i OH 96 N O Q1c a bond Me a bond NH O a bond Q3j OH 97 CH NMe Q1aa bond Me a bond NH O a bond Q3i OH 98 CH NMe Q1a a bond Me a bond NH Oa bond Q3j OH 99 CH NMe Q1b a bond Me a bond NH O a bond Q3i OH 100 CHNMe Q1b a bond Me a bond NH O a bond Q3j OH 101 CH NMe Q1c a bond Me abond NH O a bond Q3i OH 102 CH NMe Q1c a bond Me a bond NH O a bond Q3jOH 103 CH NEt Q1a a bond Me a bond NH O a bond Q3i OH 104 CH NEt Q1a abond Me a bond NH O a bond Q3j OH 105 CH NEt Q1b a bond Me a bond NH O abond Q3i OH 106 CH NEt Q1b a bond Me a bond NH O a bond Q3j OH 107 CHNEt Q1c a bond Me a bond NH O a bond Q3i OH 108 CH NEt Q1c a bond Me abond NH O a bond Q3j OH 109 CH S Q1a a bond Me a bond NH O a bond Q3i OH110 CH S Q1a a bond Me a bond NH O a bond Q3j OH 111 CH S Q1b a bond Mea bond NH O a bond Q3i OH 112 CH S Q1b a bond Me a bond NH O a bond Q3jOH 113 CH S Q1c a bond Me a bond NH O a bond Q3i OH 114 CH S Q1c a bondMe a bond NH O a bond Q3j OH 115 CH O Q1a a bond Me a bond NH O a bondQ3i OH 116 CH O Q1a a bond Me a bond NH O a bond Q3j OH 117 CH O Q1b abond Me a bond NH O a bond Q3i OH 118 CH O Q1b a bond Me a bond NH O abond Q3j OH 119 CH O Q1c a bond Me a bond NH O a bond Q3i OH 120 CH OQ1c a bond Me a bond NH O a bond Q3j OH 121 CMe NMe Q1a a bond Me a bondNH O a bond Q3i OH 122 CMe NMe Q1a a bond Me a bond NH O a bond Q3j OH123 CMe NMe Q1b a bond Me a bond NH O a bond Q3i OH 124 CMe NMe Q1b abond Me a bond NH O a bond Q3j OH 125 CMe NMe Q1c a bond Me a bond NH Oa bond Q3i OH 126 CMe NMe Q1c a bond Me a bond NH O a bond Q3j OH 127CMe NEt Q1a a bond Me a bond NH O a bond Q3i OH 128 CMe NEt Q1a a bondMe a bond NH O a bond Q3j OH 129 CMe NEt Q1b a bond Me a bond NH O abond Q3i OH 130 CMe NEt Q1b a bond Me a bond NH O a bond Q3j OH 131 CMeNEt Q1c a bond Me a bond NH O a bond Q3i OH 132 CMe NEt Q1c a bond Me abond NH O a bond Q3j OH 133 CMe S Q1a a bond Me a bond NH O a bond Q3iOH 134 CMe S Q1a a bond Me a bond NH O a bond Q3j OH 135 CMe S Q1b abond Me a bond NH O a bond Q3i OH 136 CMe S Q1b a bond Me a bond NH O abond Q3j OH 137 CMe S Q1c a bond Me a bond NH O a bond Q3i OH 138 CMe SQ1c a bond Me a bond NH O a bond Q3j OH 139 CMe O Q1a a bond Me a bondNH O a bond Q3i OH 140 CMe O Q1a a bond Me a bond NH O a bond Q3j OH 141CMe O Q1b a bond Me a bond NH O a bond Q3i OH 142 CMe O Q1b a bond Me abond NH O a bond Q3j OH 143 CMe O Q1c a bond Me a bond NH O a bond Q3iOH 144 CMe O Q1c a bond Me a bond NH O a bond Q3j OH 145 CMe NH Q1a abond Me a bond NH S NH Q3i OH 146 CMe NH Q1a a bond Me a bond NH S NHQ3j OH 147 CMe NH Q1b a bond Me a bond NH S NH Q3i OH 148 CMe NH Q1b abond Me a bond NH S NH Q3j OH 149 CMe NH Q1c a bond Me a bond NH S NHQ3i OH 150 CMe NH Q1c a bond Me a bond NH S NH Q3j OH 151 CH NH Q1a abond Me a bond NH O a bond Q3i OH 152 CH NH Q1a a bond Me a bond NH O abond Q3j OH 153 CH NH Q1b a bond Me a bond NH O a bond Q3i OH 154 CH NHQ1b a bond Me a bond NH O a bond Q3j OH 155 CH NH Q1c a bond Me a bondNH O a bond Q3i OH 156 CH NH Q1c a bond Me a bond NH O a bond Q3j OH

72) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X areany of the following combinations in Table 5, tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.The symbols in Table 5 denote the flowing substituents.

TABLE 5 No A B R¹ L¹ R² L² L³ Y L⁴ R³ X 1 CMe NH Q1k a bond Me a bond NHO a bond Q3a OH 2 CMe NH Q1k a bond Me a bond NH O a bond Q3d OH 3 CMeNH Q1k a bond Me a bond NH O a bond Q3e OH 4 CMe NH Q1k a bond Me a bondNH O a bond Q3f OH 5 CMe NH Q1k a bond Me a bond NH O NH Q3a OH 6 CMe NHQ1k a bond Me a bond NH O NH Q3d OH 7 CMe NH Q1k a bond Me a bond NH ONH Q3e OH 8 CMe NH Q1k a bond Me a bond NH O NH Q3f OH 9 CMe NH Q1k abond Me a bond NH S a bond Q3a OH 10 CMe NH Q1k a bond Me a bond NH S abond Q3d OH 11 CMe NH Q1k a bond Me a bond NH S a bond Q3e OH 12 CMe NHQ1k a bond Me a bond NH S a bond Q3f OH 13 CMe NH Q1k a bond Me a bondNH S NH Q3a OH 14 CMe NH Q1k a bond Me a bond NH S NH Q3d OH 15 CMe NHQ1k a bond Me a bond NH S NH Q3e OH 16 CMe NH Q1k a bond Me a bond NH SNH Q3f OH 17 CMe NH Q1l a bond Me a bond NH O a bond Q3a OH 18 CMe NHQ1l a bond Me a bond NH O a bond Q3d OH 19 CMe NH Q1l a bond Me a bondNH O a bond Q3e OH 20 CMe NH Q1l a bond Me a bond NH O a bond Q3f OH 21CMe NH Q1l a bond Me a bond NH O NH Q3a OH 22 CMe NH Q1l a bond Me abond NH O NH Q3d OH 23 CMe NH Q1l a bond Me a bond NH O NH Q3e OH 24 CMeNH Q1l a bond Me a bond NH O NH Q3f OH 25 CMe NH Q1l a bond Me a bond NHS a bond Q3a OH 26 CMe NH Q1l a bond Me a bond NH S a bond Q3d OH 27 CMeNH Q1l a bond Me a bond NH S a bond Q3e OH 28 CMe NH Q1l a bond Me abond NH S a bond Q3f OH 29 CMe NH Q1l a bond Me a bond NH S NH Q3a OH 30CMe NH Q1l a bond Me a bond NH S NH Q3d OH 31 CMe NH Q1l a bond Me abond NH S NH Q3e OH 32 CMe NH Q1l a bond Me a bond NH S NH Q3f OH 33 CMeNH Q1m a bond Me a bond NH O a bond Q3a OH 34 CMe NH Q1m a bond Me abond NH O a bond Q3d OH 35 CMe NH Q1m a bond Me a bond NH O a bond Q3eOH 36 CMe NH Q1m a bond Me a bond NH O a bond Q3f OH 37 CMe NH Q1m abond Me a bond NH O NH Q3a OH 38 CMe NH Q1m a bond Me a bond NH O NH Q3dOH 39 CMe NH Q1m a bond Me a bond NH O NH Q3e OH 40 CMe NH Q1m a bond Mea bond NH O NH Q3f OH 41 CMe NH Q1m a bond Me a bond NH S a bond Q3a OH42 CMe NH Q1m a bond Me a bond NH S a bond Q3d OH 43 CMe NH Q1m a bondMe a bond NH S a bond Q3e OH 44 CMe NH Q1m a bond Me a bond NH S a bondQ3f OH 45 CMe NH Q1m a bond Me a bond NH S NH Q3a OH 46 CMe NH Q1m abond Me a bond NH S NH Q3d OH 47 CMe NH Q1m a bond Me a bond NH S NH Q3eOH 48 CMe NH Q1m a bond Me a bond NH S NH Q3f OH 49 CMe NH Q1n a bond Mea bond NH O a bond Q3a OH 50 CMe NH Q1n a bond Me a bond NH O a bond Q3dOH 51 CMe NH Q1n a bond Me a bond NH O a bond Q3e OH 52 CMe NH Q1n abond Me a bond NH O a bond Q3f OH 53 CMe NH Q1n a bond Me a bond NH O NHQ3a OH 54 CMe NH Q1n a bond Me a bond NH O NH Q3d OH 55 CMe NH Q1n abond Me a bond NH O NH Q3e OH 56 CMe NH Q1n a bond Me a bond NH O NH Q3fOH 57 CMe NH Q1n a bond Me a bond NH S a bond Q3a OH 58 CMe NH Q1n abond Me a bond NH S a bond Q3d OH 59 CMe NH Q1n a bond Me a bond NH S abond Q3e OH 60 CMe NH Q1n a bond Me a bond NH S a bond Q3f OH 61 CMe NHQ1n a bond Me a bond NH S NH Q3a OH 62 CMe NH Q1n a bond Me a bond NH SNH Q3d OH 63 CMe NH Q1n a bond Me a bond NH S NH Q3e OH 64 CMe NH Q1n abond Me a bond NH S NH Q3f OH 65 CMe NH Q1k′ a bond Me a bond NH O abond Q3a OH 66 CMe NH Q1k′ a bond Me a bond NH O a bond Q3d OH 67 CMe NHQ1k′ a bond Me a bond NH O a bond Q3e OH 68 CMe NH Q1k′ a bond Me a bondNH O a bond Q3f OH 69 CMe NH Q1k′ a bond Me a bond NH O NH Q3a OH 70 CMeNH Q1k′ a bond Me a bond NH O NH Q3d OH 71 CMe NH Q1k′ a bond Me a bondNH O NH Q3e OH 72 CMe NH Q1k′ a bond Me a bond NH O NH Q3f OH 73 CMe NHQ1k′ a bond Me a bond NH S a bond Q3a OH 74 CMe NH Q1k′ a bond Me a bondNH S a bond Q3d OH 75 CMe NH Q1k′ a bond Me a bond NH S a bond Q3e OH 76CMe NH Q1k′ a bond Me a bond NH S a bond Q3f OH 77 CMe NH Q1k′ a bond Mea bond NH S NH Q3a OH 78 CMe NH Q1k′ a bond Me a bond NH S NH Q3d OH 79CMe NH Q1k′ a bond Me a bond NH S NH Q3e OH 80 CMe NH Q1k′ a bond Me abond NH S NH Q3f OH 81 CMe NH Q1l′ a bond Me a bond NH O a bond Q3a OH82 CMe NH Q1l′ a bond Me a bond NH O a bond Q3d OH 83 CMe NH Q1l′ a bondMe a bond NH O a bond Q3e OH 84 CMe NH Q1l′ a bond Me a bond NH O a bondQ3f OH 85 CMe NH Q1l′ a bond Me a bond NH O NH Q3a OH 86 CMe NH Q1l′ abond Me a bond NH O NH Q3d OH 87 CMe NH Q1l′ a bond Me a bond NH O NHQ3e OH 88 CMe NH Q1l′ a bond Me a bond NH O NH Q3f OH 89 CMe NH Q1l′ abond Me a bond NH S a bond Q3a OH 90 CMe NH Q1l′ a bond Me a bond NH S abond Q3d OH 91 CMe NH Q1l′ a bond Me a bond NH S a bond Q3e OH 92 CMe NHQ1l′ a bond Me a bond NH S a bond Q3f OH 93 CMe NH Q1l′ a bond Me a bondNH S NH Q3a OH 94 CMe NH Q1l′ a bond Me a bond NH S NH Q3d OH 95 CMe NHQ1l′ a bond Me a bond NH S NH Q3e OH 96 CMe NH Q1l′ a bond Me a bond NHS NH Q3f OH 97 CMe NH Q1m′ a bond Me a bond NH O a bond Q3a OH 98 CMe NHQ1m′ a bond Me a bond NH O a bond Q3d OH 99 CMe NH Q1m′ a bond Me a bondNH O a bond Q3e OH 100 CMe NH Q1m′ a bond Me a bond NH O a bond Q3f OH101 CMe NH Q1m′ a bond Me a bond NH O NH Q3a OH 102 CMe NH Q1m′ a bondMe a bond NH O NH Q3d OH 103 CMe NH Q1m′ a bond Me a bond NH O NH Q3e OH104 CMe NH Q1m′ a bond Me a bond NH O NH Q3f OH 105 CMe NH Q1m′ a bondMe a bond NH S a bond Q3a OH 106 CMe NH Q1m′ a bond Me a bond NH S abond Q3d OH 107 CMe NH Q1m′ a bond Me a bond NH S a bond Q3e OH 108 CMeNH Q1m′ a bond Me a bond NH S a bond Q3f OH 109 CMe NH Q1m′ a bond Me abond NH S NH Q3a OH 110 CMe NH Q1m′ a bond Me a bond NH S NH Q3d OH 111CMe NH Q1m′ a bond Me a bond NH S NH Q3e OH 112 CMe NH Q1m′ a bond Me abond NH S NH Q3f OH 113 CMe NH Q1n′ a bond Me a bond NH O a bond Q3a OH114 CMe NH Q1n′ a bond Me a bond NH O a bond Q3d OH 115 CMe NH Q1n′ abond Me a bond NH O a bond Q3e OH 116 CMe NH Q1n′ a bond Me a bond NH Oa bond Q3f OH 117 CMe NH Q1n′ a bond Me a bond NH O NH Q3a OH 118 CMe NHQ1n′ a bond Me a bond NH O NH Q3d OH 119 CMe NH Q1n′ a bond Me a bond NHO NH Q3e OH 120 CMe NH Q1n′ a bond Me a bond NH O NH Q3f OH 121 CMe NHQ1n′ a bond Me a bond NH S a bond Q3a OH 122 CMe NH Q1n′ a bond Me abond NH S a bond Q3d OH 123 CMe NH Q1n′ a bond Me a bond NH S a bond Q3eOH 124 CMe NH Q1n′ a bond Me a bond NH S a bond Q3f OH 125 CMe NH Q1n′ abond Me a bond NH S NH Q3a OH 126 CMe NH Q1n′ a bond Me a bond NH S NHQ3d OH 127 CMe NH Q1n′ a bond Me a bond NH S NH Q3e OH 128 CMe NH Q1n′ abond Me a bond NH S NH Q3f OH 129 CMe NH Q1a a bond Me a bond NH O abond Q3d OH 130 CMe NH Q1a a bond Me a bond NH O a bond Q3e OH 131 CMeNH Q1a a bond Me a bond NH O a bond Q3f OH 132 CMe NH Q1a a bond Me abond NH O NH Q3d OH 133 CMe NH Q1a a bond Me a bond NH O NH Q3e OH 134CMe NH Q1a a bond Me a bond NH O NH Q3f OH 135 CMe NH Q1a a bond Me abond NH S a bond Q3d OH 136 CMe NH Q1a a bond Me a bond NH S a bond Q3eOH 137 CMe NH Q1a a bond Me a bond NH S a bond Q3f OH 138 CMe NH Q1a abond Me a bond NH S NH Q3d OH 139 CMe NH Q1a a bond Me a bond NH S NHQ3e OH 140 CMe NH Q1a a bond Me a bond NH S NH Q3f OH 141 CMe NH Q1b abond Me a bond NH O a bond Q3d OH 142 CMe NH Q1b a bond Me a bond NH O abond Q3e OH 143 CMe NH Q1b a bond Me a bond NH O a bond Q3f OH 144 CMeNH Q1b a bond Me a bond NH O NH Q3d OH 145 CMe NH Q1b a bond Me a bondNH O NH Q3e OH 146 CMe NH Q1b a bond Me a bond NH O NH Q3f OH 147 CMe NHQ1b a bond Me a bond NH S a bond Q3d OH 148 CMe NH Q1b a bond Me a bondNH S a bond Q3e OH 149 CMe NH Q1b a bond Me a bond NH S a bond Q3f OH150 CMe NH Q1b a bond Me a bond NH S NH Q3d OH 151 CMe NH Q1b a bond Mea bond NH S NH Q3e OH 152 CMe NH Q1b a bond Me a bond NH S NH Q3f OH 153CMe NH Q1c a bond Me a bond NH O a bond Q3d OH 154 CMe NH Q1c a bond Mea bond NH O a bond Q3e OH 155 CMe NH Q1c a bond Me a bond NH O a bondQ3f OH 156 CMe NH Q1c a bond Me a bond NH O NH Q3d OH 157 CMe NH Q1c abond Me a bond NH O NH Q3e OH 158 CMe NH Q1c a bond Me a bond NH O NHQ3f OH 159 CMe NH Q1c a bond Me a bond NH S a bond Q3d OH 160 CMe NH Q1ca bond Me a bond NH S a bond Q3e OH 161 CMe NH Q1c a bond Me a bond NH Sa bond Q3f OH 162 CMe NH Q1c a bond Me a bond NH S NH Q3d OH 163 CMe NHQ1c a bond Me a bond NH S NH Q3e OH 164 CMe NH Q1a a bond Me a bond NH SNH Q3g OH 165 CMe NH Q1a a bond Me a bond NH S NH Q3h OH 166 CMe NH Q1ba bond Me a bond NH S NH Q3g OH 167 CMe NH Q1b a bond Me a bond NH S NHQ3h OH 168 CMe NH Q1c a bond Me a bond NH S NH Q3g OH 169 CMe NH Q1c abond Me a bond NH S NH Q3h OH 170 CMe NH Q1a a bond Me a bond NH O abond Q3g OH 171 CMe NH Q1a a bond Me a bond NH O a bond Q3h OH 172 CMeNH Q1b a bond Me a bond NH O a bond Q3g OH 173 CMe NH Q1b a bond Me abond NH O a bond Q3h OH 174 CMe NH Q1c a bond Me a bond NH S a bond Q3gOH 175 CMe NH Q1c a bond Me a bond NH S a bond Q3h OH 176 CMe NH Q1c abond Me a bond NH S NH Q3f OH

73) The compounds wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³ and X areany of the following combinations in Table 6, tautomers, prodrugs orpharmaceutically acceptable salts of the compounds or solvates thereof.The symbols in Table 6 denote the following substituents.

TABLE 6 No A B R¹ L¹ R² L² L³ Y L⁴ R³ X 1 N NMe Q1a a bond Me a bond NHS NH T3a OH 2 N NMe Q1a a bond Me a bond NH S NH T3b OH 3 N NMe Q1a abond Me a bond NH S NH T3c OH 4 N NMe Q1a a bond Me a bond NH S NH T3dOH 5 N NMe Q1a a bond Me a bond NH S NH T3e OH 6 N NMe Q1a a bond Me abond NH S NH T3f OH 7 N NMe Q1a a bond Me a bond NH S NH T3g OH 8 N NMeQ1a a bond Me a bond NH S NH T3h OH 9 N NMe Q1a a bond Me a bond NH S NHT3i OH 10 N NMe Q1a a bond Me a bond NH S NH T3j OH 11 N NMe Q1a a bondMe a bond NH S a bond T3a OH 12 N NMe Q1a a bond Me a bond NH S a bondT3b OH 13 N NMe Q1a a bond Me a bond NH S a bond T3c OH 14 N NMe Q1a abond Me a bond NH S a bond T3d OH 15 N NMe Q1a a bond Me a bond NH S abond T3e OH 16 N NMe Q1a a bond Me a bond NH S a bond T3f OH 17 N NMeQ1a a bond Me a bond NH S a bond T3g OH 18 N NMe Q1a a bond Me a bond NHS a bond T3h OH 19 N NMe Q1a a bond Me a bond NH S a bond T3i OH 20 NNMe Q1a a bond Me a bond NH S a bond T3j OH 21 N NMe Q1a a bond Me abond NH O NH T3a OH 22 N NMe Q1a a bond Me a bond NH O NH T3b OH 23 NNMe Q1a a bond Me a bond NH O NH T3c OH 24 N NMe Q1a a bond Me a bond NHO NH T3d OH 25 N NMe Q1a a bond Me a bond NH O NH T3e OH 26 N NMe Q1a abond Me a bond NH O NH T3f OH 27 N NMe Q1a a bond Me a bond NH O NH T3gOH 28 N NMe Q1a a bond Me a bond NH O NH T3h OH 29 N NMe Q1a a bond Me abond NH O NH T3i OH 30 N NMe Q1a a bond Me a bond NH O NH T3j OH 31 NNMe Q1a a bond Me a bond NH O a bond T3a OH 32 N NMe Q1a a bond Me abond NH O a bond T3b OH 33 N NMe Q1a a bond Me a bond NH O a bond T3c OH34 N NMe Q1a a bond Me a bond NH O a bond T3d OH 35 N NMe Q1a a bond Mea bond NH O a bond T3e OH 36 N NMe Q1a a bond Me a bond NH O a bond T3fOH 37 N NMe Q1a a bond Me a bond NH O a bond T3g OH 38 N NMe Q1a a bondMe a bond NH O a bond T3h OH 39 N NMe Q1a a bond Me a bond NH O a bondT3i OH 40 N NMe Q1a a bond Me a bond NH O a bond T3j OH 41 N NMe Q1a abond H a bond NH S NH T3a OH 42 N NMe Q1a a bond H a bond NH S NH T3b OH43 N NMe Q1a a bond H a bond NH S NH T3c OH 44 N NMe Q1a a bond H a bondNH S NH T3d OH 45 N NMe Q1a a bond H a bond NH S NH T3e OH 46 N NMe Q1aa bond H a bond NH S NH T3f OH 47 N NMe Q1a a bond H a bond NH S NH T3gOH 48 N NMe Q1a a bond H a bond NH S NH T3h OH 49 N NMe Q1a a bond H abond NH S NH T3i OH 50 N NMe Q1a a bond H a bond NH S NH T3j OH 51 N NMeQ1a a bond H a bond NH S a bond T3a OH 52 N NMe Q1a a bond H a bond NH Sa bond T3b OH 53 N NMe Q1a a bond H a bond NH S a bond T3c OH 54 N NMeQ1a a bond H a bond NH S a bond T3d OH 55 N NMe Q1a a bond H a bond NH Sa bond T3e OH 56 N NMe Q1a a bond H a bond NH S a bond T3f OH 57 N NMeQ1a a bond H a bond NH S a bond T3g OH 58 N NMe Q1a a bond H a bond NH Sa bond T3h OH 59 N NMe Q1a a bond H a bond NH S a bond T3i OH 60 N NMeQ1a a bond H a bond NH S a bond T3j OH 61 N NMe Q1a a bond H a bond NH ONH T3a OH 62 N NMe Q1a a bond H a bond NH O NH T3b OH 63 N NMe Q1a abond H a bond NH O NH T3c OH 64 N NMe Q1a a bond H a bond NH O NH T3d OH65 N NMe Q1a a bond H a bond NH O NH T3e OH 66 N NMe Q1a a bond H a bondNH O NH T3f OH 67 N NMe Q1a a bond H a bond NH O NH T3g OH 68 N NMe Q1aa bond H a bond NH O NH T3h OH 69 N NMe Q1a a bond H a bond NH O NH T3iOH 70 N NMe Q1a a bond H a bond NH O NH T3j OH 71 N NMe Q1a a bond H abond NH O a bond T3a OH 72 N NMe Q1a a bond H a bond NH O a bond T3b OH73 N NMe Q1a a bond H a bond NH O a bond T3c OH 74 N NMe Q1a a bond H abond NH O a bond T3d OH 75 N NMe Q1a a bond H a bond NH O a bond T3e OH76 N NMe Q1a a bond H a bond NH O a bond T3f OH 77 N NMe Q1a a bond H abond NH O a bond T3g OH 78 N NMe Q1a a bond H a bond NH O a bond T3h OH79 N NMe Q1a a bond H a bond NH O a bond T3i OH 80 N NMe Q1a a bond H abond NH O a bond T3j OH 81 N NMe Q1b a bond Me a bond NH S NH T3a OH 82N NMe Q1b a bond Me a bond NH S NH T3b OH 83 N NMe Q1b a bond Me a bondNH S NH T3c OH 84 N NMe Q1b a bond Me a bond NH S NH T3d OH 85 N NMe Q1ba bond Me a bond NH S NH T3e OH 86 N NMe Q1b a bond Me a bond NH S NHT3f OH 87 N NMe Q1b a bond Me a bond NH S NH T3g OH 88 N NMe Q1b a bondMe a bond NH S NH T3h OH 89 N NMe Q1b a bond Me a bond NH S NH T3i OH 90N NMe Q1b a bond Me a bond NH S NH T3j OH 91 N NMe Q1b a bond Me a bondNH S a bond T3a OH 92 N NMe Q1b a bond Me a bond NH S a bond T3b OH 93 NNMe Q1b a bond Me a bond NH S a bond T3c OH 94 N NMe Q1b a bond Me abond NH S a bond T3d OH 95 N NMe Q1b a bond Me a bond NH S a bond T3e OH96 N NMe Q1b a bond Me a bond NH S a bond T3f OH 97 N NMe Q1b a bond Mea bond NH S a bond T3g OH 98 N NMe Q1b a bond Me a bond NH S a bond T3hOH 99 N NMe Q1b a bond Me a bond NH S a bond T3i OH 100 N NMe Q1b a bondMe a bond NH S a bond T3j OH 101 N NMe Q1b a bond Me a bond NH O NH T3aOH 102 N NMe Q1b a bond Me a bond NH O NH T3b OH 103 N NMe Q1b a bond Mea bond NH O NH T3c OH 104 N NMe Q1b a bond Me a bond NH O NH T3d OH 105N NMe Q1b a bond Me a bond NH O NH T3e OH 106 N NMe Q1b a bond Me a bondNH O NH T3f OH 107 N NMe Q1b a bond Me a bond NH O NH T3g OH 108 N NMeQ1b a bond Me a bond NH O NH T3h OH 109 N NMe Q1b a bond Me a bond NH ONH T3i OH 110 N NMe Q1b a bond Me a bond NH O NH T3j OH 111 N NMe Q1b abond Me a bond NH O a bond T3a OH 112 N NMe Q1b a bond Me a bond NH O abond T3b OH 113 N NMe Q1b a bond Me a bond NH O a bond T3c OH 114 N NMeQ1b a bond Me a bond NH O a bond T3d OH 115 N NMe Q1b a bond Me a bondNH O a bond T3e OH 116 N NMe Q1b a bond Me a bond NH O a bond T3f OH 117N NMe Q1b a bond Me a bond NH O a bond T3g OH 118 N NMe Q1b a bond Me abond NH O a bond T3h OH 119 N NMe Q1b a bond Me a bond NH O a bond T3iOH 120 N NMe Q1b a bond Me a bond NH O a bond T3j OH 121 N NMe Q1b abond H a bond NH S NH T3a OH 122 N NMe Q1b a bond H a bond NH S NH T3bOH 123 N NMe Q1b a bond H a bond NH S NH T3c OH 124 N NMe Q1b a bond H abond NH S NH T3d OH 125 N NMe Q1b a bond H a bond NH S NH T3e OH 126 NNMe Q1b a bond H a bond NH S NH T3f OH 127 N NMe Q1b a bond H a bond NHS NH T3g OH 128 N NMe Q1b a bond H a bond NH S NH T3h OH 129 N NMe Q1b abond H a bond NH S NH T3i OH 130 N NMe Q1b a bond H a bond NH S NH T3jOH 131 N NMe Q1b a bond H a bond NH S a bond T3a OH 132 N NMe Q1b a bondH a bond NH S a bond T3b OH 133 N NMe Q1b a bond H a bond NH S a bondT3c OH 134 N NMe Q1b a bond H a bond NH S a bond T3d OH 135 N NMe Q1b abond H a bond NH S a bond T3e OH 136 N NMe Q1b a bond H a bond NH S abond T3f OH 137 N NMe Q1b a bond H a bond NH S a bond T3g OH 138 N NMeQ1b a bond H a bond NH S a bond T3h OH 139 N NMe Q1b a bond H a bond NHS a bond T3i OH 140 N NMe Q1b a bond H a bond NH S a bond T3j OH 141 NNMe Q1b a bond H a bond NH O NH T3a OH 142 N NMe Q1b a bond H a bond NHO NH T3b OH 143 N NMe Q1b a bond H a bond NH O NH T3c OH 144 N NMe Q1b abond H a bond NH O NH T3d OH 145 N NMe Q1b a bond H a bond NH O NH T3eOH 146 N NMe Q1b a bond H a bond NH O NH T3f OH 147 N NMe Q1b a bond H abond NH O NH T3g OH 148 N NMe Q1b a bond H a bond NH O NH T3h OH 149 NNMe Q1b a bond H a bond NH O NH T3i OH 150 N NMe Q1b a bond H a bond NHO NH T3j OH 151 N NMe Q1b a bond H a bond NH O a bond T3a OH 152 N NMeQ1b a bond H a bond NH O a bond T3b OH 153 N NMe Q1b a bond H a bond NHO a bond T3c OH 154 N NMe Q1b a bond H a bond NH O a bond T3d OH 155 NNMe Q1b a bond H a bond NH O a bond T3e OH 156 N NMe Q1b a bond H a bondNH O a bond T3f OH 157 N NMe Q1b a bond H a bond NH O a bond T3g OH 158N NMe Q1b a bond H a bond NH O a bond T3h OH 159 N NMe Q1b a bond H abond NH O a bond T3i OH 160 N NMe Q1b a bond H a bond NH O a bond T3j OH161 N NMe Q1c a bond Me a bond NH S NH T3a OH 162 N NMe Q1c a bond Me abond NH S NH T3b OH 163 N NMe Q1c a bond Me a bond NH S NH T3c OH 164 NNMe Q1c a bond Me a bond NH S NH T3d OH 165 N NMe Q1c a bond Me a bondNH S NH T3e OH 166 N NMe Q1c a bond Me a bond NH S NH T3f OH 167 N NMeQ1c a bond Me a bond NH S NH T3g OH 168 N NMe Q1c a bond Me a bond NH SNH T3h OH 169 N NMe Q1c a bond Me a bond NH S NH T3i OH 170 N NMe Q1c abond Me a bond NH S NH T3j OH 171 N NMe Q1c a bond Me a bond NH S a bondT3a OH 172 N NMe Q1c a bond Me a bond NH S a bond T3b OH 173 N NMe Q1c abond Me a bond NH S a bond T3c OH 174 N NMe Q1c a bond Me a bond NH S abond T3d OH 175 N NMe Q1c a bond Me a bond NH S a bond T3e OH 176 N NMeQ1c a bond Me a bond NH S a bond T3f OH 177 N NMe Q1c a bond Me a bondNH S a bond T3g OH 178 N NMe Q1c a bond Me a bond NH S a bond T3h OH 179N NMe Q1c a bond Me a bond NH S a bond T3i OH 180 N NMe Q1c a bond Me abond NH S a bond T3j OH 181 N NMe Q1c a bond Me a bond NH O NH T3a OH182 N NMe Q1c a bond Me a bond NH O NH T3b OH 183 N NMe Q1c a bond Me abond NH O NH T3c OH 184 N NMe Q1c a bond Me a bond NH O NH T3d OH 185 NNMe Q1c a bond Me a bond NH O NH T3e OH 186 N NMe Q1c a bond Me a bondNH O NH T3f OH 187 N NMe Q1c a bond Me a bond NH O NH T3g OH 188 N NMeQ1c a bond Me a bond NH O NH T3h OH 189 N NMe Q1c a bond Me a bond NH ONH T3i OH 190 N NMe Q1c a bond Me a bond NH O NH T3j OH 191 N NMe Q1c abond Me a bond NH O a bond T3a OH 192 N NMe Q1c a bond Me a bond NH O abond T3b OH 193 N NMe Q1c a bond Me a bond NH O a bond T3c OH 194 N NMeQ1c a bond Me a bond NH O a bond T3d OH 195 N NMe Q1c a bond Me a bondNH O a bond T3e OH 196 N NMe Q1c a bond Me a bond NH O a bond T3f OH 197N NMe Q1c a bond Me a bond NH O a bond T3g OH 198 N NMe Q1c a bond Me abond NH O a bond T3h OH 199 N NMe Q1c a bond Me a bond NH O a bond T3iOH 200 N NMe Q1c a bond Me a bond NH O a bond T3j OH 201 N NMe Q1c abond H a bond NH S NH T3a OH 202 N NMe Q1c a bond H a bond NH S NH T3bOH 203 N NMe Q1c a bond H a bond NH S NH T3c OH 204 N NMe Q1c a bond H abond NH S NH T3d OH 205 N NMe Q1c a bond H a bond NH S NH T3e OH 206 NNMe Q1c a bond H a bond NH S NH T3f OH 207 N NMe Q1c a bond H a bond NHS NH T3g OH 208 N NMe Q1c a bond H a bond NH S NH T3h OH 209 N NMe Q1c abond H a bond NH S NH T3i OH 210 N NMe Q1c a bond H a bond NH S NH T3jOH 211 N NMe Q1c a bond H a bond NH S a bond T3a OH 212 N NMe Q1c a bondH a bond NH S a bond T3b OH 213 N NMe Q1c a bond H a bond NH S a bondT3c OH 214 N NMe Q1c a bond H a bond NH S a bond T3d OH 215 N NMe Q1c abond H a bond NH S a bond T3e OH 216 N NMe Q1c a bond H a bond NH S abond T3f OH 217 N NMe Q1c a bond H a bond NH S a bond T3g OH 218 N NMeQ1c a bond H a bond NH S a bond T3h OH 219 N NMe Q1c a bond H a bond NHS a bond T3i OH 220 N NMe Q1c a bond H a bond NH S a bond T3j OH 221 NNMe Q1c a bond H a bond NH O NH T3a OH 222 N NMe Q1c a bond H a bond NHO NH T3b OH 223 N NMe Q1c a bond H a bond NH O NH T3c OH 224 N NMe Q1c abond H a bond NH O NH T3d OH 225 N NMe Q1c a bond H a bond NH O NH T3eOH 226 N NMe Q1c a bond H a bond NH O NH T3f OH 227 N NMe Q1c a bond H abond NH O NH T3g OH 228 N NMe Q1c a bond H a bond NH O NH T3h OH 229 NNMe Q1c a bond H a bond NH O NH T3i OH 230 N NMe Q1c a bond H a bond NHO NH T3j OH 231 N NMe Q1c a bond H a bond NH O a bond T3a OH 232 N NMeQ1c a bond H a bond NH O a bond T3b OH 233 N NMe Q1c a bond H a bond NHO a bond T3c OH 234 N NMe Q1c a bond H a bond NH O a bond T3d OH 235 NNMe Q1c a bond H a bond NH O a bond T3e OH 236 N NMe Q1c a bond H a bondNH O a bond T3f OH 237 N NMe Q1c a bond H a bond NH O a bond T3g OH 238N NMe Q1c a bond H a bond NH O a bond T3h OH 239 N NMe Q1c a bond H abond NH O a bond T3i OH 240 N NMe Q1c a bond H a bond NH O a bond T3j OH241 N NMe Q1i a bond Me a bond NH S NH T3a OH 242 N NMe Q1i a bond Me abond NH S NH T3b OH 243 N NMe Q1i a bond Me a bond NH S NH T3c OH 244 NNMe Q1i a bond Me a bond NH S NH T3d OH 245 N NMe Q1i a bond Me a bondNH S NH T3e OH 246 N NMe Q1i a bond Me a bond NH S NH T3f OH 247 N NMeQ1i a bond Me a bond NH S NH T3g OH 248 N NMe Q1i a bond Me a bond NH SNH T3h OH 249 N NMe Q1i a bond Me a bond NH S NH T3i OH 250 N NMe Q1i abond Me a bond NH S NH T3j OH 251 N NMe Q1i a bond Me a bond NH S a bondT3a OH 252 N NMe Q1i a bond Me a bond NH S a bond T3b OH 253 N NMe Q1i abond Me a bond NH S a bond T3c OH 254 N NMe Q1i a bond Me a bond NH S abond T3d OH 255 N NMe Q1i a bond Me a bond NH S a bond T3e OH 256 N NMeQ1i a bond Me a bond NH S a bond T3f OH 257 N NMe Q1i a bond Me a bondNH S a bond T3g OH 258 N NMe Q1i a bond Me a bond NH S a bond T3h OH 259N NMe Q1i a bond Me a bond NH S a bond T3i OH 260 N NMe Q1i a bond Me abond NH S a bond T3j OH 261 N NMe Q1i a bond Me a bond NH O NH T3a OH262 N NMe Q1i a bond Me a bond NH O NH T3b OH 263 N NMe Q1i a bond Me abond NH O NH T3c OH 264 N NMe Q1i a bond Me a bond NH O NH T3d OH 265 NNMe Q1i a bond Me a bond NH O NH T3e OH 266 N NMe Q1i a bond Me a bondNH O NH T3f OH 267 N NMe Q1i a bond Me a bond NH O NH T3g OH 268 N NMeQ1i a bond Me a bond NH O NH T3h OH 269 N NMe Q1i a bond Me a bond NH ONH T3i OH 270 N NMe Q1i a bond Me a bond NH O NH T3j OH 271 N NMe Q1i abond Me a bond NH O a bond T3a OH 272 N NMe Q1i a bond Me a bond NH O abond T3b OH 273 N NMe Q1i a bond Me a bond NH O a bond T3c OH 274 N NMeQ1i a bond Me a bond NH O a bond T3d OH 275 N NMe Q1i a bond Me a bondNH O a bond T3e OH 276 N NMe Q1i a bond Me a bond NH O a bond T3f OH 277N NMe Q1i a bond Me a bond NH O a bond T3g OH 278 N NMe Q1i a bond Me abond NH O a bond T3h OH 279 N NMe Q1i a bond Me a bond NH O a bond T3iOH 280 N NMe Q1i a bond Me a bond NH O a bond T3j OH 281 N NMe Q1i abond H a bond NH S NH T3a OH 282 N NMe Q1i a bond H a bond NH S NH T3bOH 283 N NMe Q1i a bond H a bond NH S NH T3c OH 284 N NMe Q1i a bond H abond NH S NH T3d OH 285 N NMe Q1i a bond H a bond NH S NH T3e OH 286 NNMe Q1i a bond H a bond NH S NH T3f OH 287 N NMe Q1i a bond H a bond NHS NH T3g OH 288 N NMe Q1i a bond H a bond NH S NH T3h OH 289 N NMe Q1i abond H a bond NH S NH T3i OH 290 N NMe Q1i a bond H a bond NH S NH T3jOH 291 N NMe Q1i a bond H a bond NH S a bond T3a OH 292 N NMe Q1i a bondH a bond NH S a bond T3b OH 293 N NMe Q1i a bond H a bond NH S a bondT3c OH 294 N NMe Q1i a bond H a bond NH S a bond T3d OH 295 N NMe Q1i abond H a bond NH S a bond T3e OH 296 N NMe Q1i a bond H a bond NH S abond T3f OH 297 N NMe Q1i a bond H a bond NH S a bond T3g OH 298 N NMeQ1i a bond H a bond NH S a bond T3h OH 299 N NMe Q1i a bond H a bond NHS a bond T3i OH 300 N NMe Q1i a bond H a bond NH S a bond T3j OH 301 NNMe Q1i a bond H a bond NH O NH T3a OH 302 N NMe Q1i a bond H a bond NHO NH T3b OH 303 N NMe Q1i a bond H a bond NH O NH T3c OH 304 N NMe Q1i abond H a bond NH O NH T3d OH 305 N NMe Q1i a bond H a bond NH O NH T3eOH 306 N NMe Q1i a bond H a bond NH O NH T3f OH 307 N NMe Q1i a bond H abond NH O NH T3g OH 308 N NMe Q1i a bond H a bond NH O NH T3h OH 309 NNMe Q1i a bond H a bond NH O NH T3i OH 310 N NMe Q1i a bond H a bond NHO NH T3j OH 311 N NMe Q1i a bond H a bond NH O a bond T3a OH 312 N NMeQ1i a bond H a bond NH O a bond T3b OH 313 N NMe Q1i a bond H a bond NHO a bond T3c OH 314 N NMe Q1i a bond H a bond NH O a bond T3d OH 315 NNMe Q1i a bond H a bond NH O a bond T3e OH 316 N NMe Q1i a bond H a bondNH O a bond T3f OH 317 N NMe Q1i a bond H a bond NH O a bond T3g OH 318N NMe Q1i a bond H a bond NH O a bond T3h OH 319 N NMe Q1i a bond H abond NH O a bond T3i OH 320 N NMe Q1i a bond H a bond NH O a bond T3j OH321 N NMe Q1j a bond Me a bond NH S NH T3a OH 322 N NMe Q1j a bond Me abond NH S NH T3b OH 323 N NMe Q1j a bond Me a bond NH S NH T3c OH 324 NNMe Q1j a bond Me a bond NH S NH T3d OH 325 N NMe Q1j a bond Me a bondNH S NH T3e OH 326 N NMe Q1j a bond Me a bond NH S NH T3f OH 327 N NMeQ1j a bond Me a bond NH S NH T3g OH 328 N NMe Q1j a bond Me a bond NH SNH T3h OH 329 N NMe Q1j a bond Me a bond NH S NH T3i OH 330 N NMe Q1j abond Me a bond NH S NH T3j OH 331 N NMe Q1j a bond Me a bond NH S a bondT3a OH 332 N NMe Q1j a bond Me a bond NH S a bond T3b OH 333 N NMe Q1j abond Me a bond NH S a bond T3c OH 334 N NMe Q1j a bond Me a bond NH S abond T3d OH 335 N NMe Q1j a bond Me a bond NH S a bond T3e OH 336 N NMeQ1j a bond Me a bond NH S a bond T3f OH 337 N NMe Q1j a bond Me a bondNH S a bond T3g OH 338 N NMe Q1j a bond Me a bond NH S a bond T3h OH 339N NMe Q1j a bond Me a bond NH S a bond T3i OH 340 N NMe Q1j a bond Me abond NH S a bond T3j OH 341 N NMe Q1j a bond Me a bond NH O NH T3a OH342 N NMe Q1j a bond Me a bond NH O NH T3b OH 343 N NMe Q1j a bond Me abond NH O NH T3c OH 344 N NMe Q1j a bond Me a bond NH O NH T3d OH 345 NNMe Q1j a bond Me a bond NH O NH T3e OH 346 N NMe Q1j a bond Me a bondNH O NH T3f OH 347 N NMe Q1j a bond Me a bond NH O NH T3g OH 348 N NMeQ1j a bond Me a bond NH O NH T3h OH 349 N NMe Q1j a bond Me a bond NH ONH T3i OH 350 N NMe Q1j a bond Me a bond NH O NH T3j OH 351 N NMe Q1j abond Me a bond NH O a bond T3a OH 352 N NMe Q1j a bond Me a bond NH O abond T3b OH 353 N NMe Q1j a bond Me a bond NH O a bond T3c OH 354 N NMeQ1j a bond Me a bond NH O a bond T3d OH 355 N NMe Q1j a bond Me a bondNH O a bond T3e OH 356 N NMe Q1j a bond Me a bond NH O a bond T3f OH 357N NMe Q1j a bond Me a bond NH O a bond T3g OH 358 N NMe Q1j a bond Me abond NH O a bond T3h OH 359 N NMe Q1j a bond Me a bond NH O a bond T3iOH 360 N NMe Q1j a bond Me a bond NH O a bond T3j OH 361 N NMe Q1j abond H a bond NH S NH T3a OH 362 N NMe Q1j a bond H a bond NH S NH T3bOH 363 N NMe Q1j a bond H a bond NH S NH T3c OH 364 N NMe Q1j a bond H abond NH S NH T3d OH 365 N NMe Q1j a bond H a bond NH S NH T3e OH 366 NNMe Q1j a bond H a bond NH S NH T3f OH 367 N NMe Q1j a bond H a bond NHS NH T3g OH 368 N NMe Q1j a bond H a bond NH S NH T3h OH 369 N NMe Q1j abond H a bond NH S NH T3i OH 370 N NMe Q1j a bond H a bond NH S NH T3jOH 371 N NMe Q1j a bond H a bond NH S a bond T3a OH 372 N NMe Q1j a bondH a bond NH S a bond T3b OH 373 N NMe Q1j a bond H a bond NH S a bondT3c OH 374 N NMe Q1j a bond H a bond NH S a bond T3d OH 375 N NMe Q1j abond H a bond NH S a bond T3e OH 376 N NMe Q1j a bond H a bond NH S abond T3f OH 377 N NMe Q1j a bond H a bond NH S a bond T3g OH 378 N NMeQ1j a bond H a bond NH S a bond T3h OH 379 N NMe Q1j a bond H a bond NHS a bond T3i OH 380 N NMe Q1j a bond H a bond NH S a bond T3j OH 381 NNMe Q1j a bond H a bond NH O NH T3a OH 382 N NMe Q1j a bond H a bond NHO NH T3b OH 383 N NMe Q1j a bond H a bond NH O NH T3c OH 384 N NMe Q1j abond H a bond NH O NH T3d OH 385 N NMe Q1j a bond H a bond NH O NH T3eOH 386 N NMe Q1j a bond H a bond NH O NH T3f OH 387 N NMe Q1j a bond H abond NH O NH T3g OH 388 N NMe Q1j a bond H a bond NH O NH T3h OH 389 NNMe Q1j a bond H a bond NH O NH T3i OH 390 N NMe Q1j a bond H a bond NHO NH T3j OH 391 N NMe Q1j a bond H a bond NH O a bond T3a OH 392 N NMeQ1j a bond H a bond NH O a bond T3b OH 393 N NMe Q1j a bond H a bond NHO a bond T3c OH 394 N NMe Q1j a bond H a bond NH O a bond T3d OH 395 NNMe Q1j a bond H a bond NH O a bond T3e OH 396 N NMe Q1j a bond H a bondNH O a bond T3f OH 397 N NMe Q1j a bond H a bond NH O a bond T3g OH 398N NMe Q1j a bond H a bond NH O a bond T3h OH 399 N NMe Q1j a bond H abond NH O a bond T3i OH 400 N NMe Q1j a bond H a bond NH O a bond T3j OH401 N S Q1a a bond Me a bond NH S NH T3a OH 402 N S Q1a a bond Me a bondNH S NH T3b OH 403 N S Q1a a bond Me a bond NH S NH T3c OH 404 N S Q1a abond Me a bond NH S NH T3d OH 405 N S Q1a a bond Me a bond NH S NH T3eOH 406 N S Q1a a bond Me a bond NH S NH T3f OH 407 N S Q1a a bond Me abond NH S NH T3g OH 408 N S Q1a a bond Me a bond NH S NH T3h OH 409 N SQ1a a bond Me a bond NH S NH T3i OH 410 N S Q1a a bond Me a bond NH S NHT3j OH 411 N S Q1a a bond Me a bond NH S a bond T3a OH 412 N S Q1a abond Me a bond NH S a bond T3b OH 413 N S Q1a a bond Me a bond NH S abond T3c OH 414 N S Q1a a bond Me a bond NH S a bond T3d OH 415 N S Q1aa bond Me a bond NH S a bond T3e OH 416 N S Q1a a bond Me a bond NH S abond T3f OH 417 N S Q1a a bond Me a bond NH S a bond T3g OH 418 N S Q1aa bond Me a bond NH S a bond T3h OH 419 N S Q1a a bond Me a bond NH S abond T3i OH 420 N S Q1a a bond Me a bond NH S a bond T3j OH 421 N S Q1aa bond Me a bond NH O NH T3a OH 422 N S Q1a a bond Me a bond NH O NH T3bOH 423 N S Q1a a bond Me a bond NH O NH T3c OH 424 N S Q1a a bond Me abond NH O NH T3d OH 425 N S Q1a a bond Me a bond NH O NH T3e OH 426 N SQ1a a bond Me a bond NH O NH T3f OH 427 N S Q1a a bond Me a bond NH O NHT3g OH 428 N S Q1a a bond Me a bond NH O NH T3h OH 429 N S Q1a a bond Mea bond NH O NH T3i OH 430 N S Q1a a bond Me a bond NH O NH T3j OH 431 NS Q1a a bond Me a bond NH O a bond T3a OH 432 N S Q1a a bond Me a bondNH O a bond T3b OH 433 N S Q1a a bond Me a bond NH O a bond T3c OH 434 NS Q1a a bond Me a bond NH O a bond T3d OH 435 N S Q1a a bond Me a bondNH O a bond T3e OH 436 N S Q1a a bond Me a bond NH O a bond T3f OH 437 NS Q1a a bond Me a bond NH O a bond T3g OH 438 N S Q1a a bond Me a bondNH O a bond T3h OH 439 N S Q1a a bond Me a bond NH O a bond T3i OH 440 NS Q1a a bond Me a bond NH O a bond T3j OH 441 N S Q1a a bond H a bond NHS NH T3a OH 442 N S Q1a a bond H a bond NH S NH T3b OH 443 N S Q1a abond H a bond NH S NH T3c OH 444 N S Q1a a bond H a bond NH S NH T3d OH445 N S Q1a a bond H a bond NH S NH T3e OH 446 N S Q1a a bond H a bondNH S NH T3f OH 447 N S Q1a a bond H a bond NH S NH T3g OH 448 N S Q1a abond H a bond NH S NH T3h OH 449 N S Q1a a bond H a bond NH S NH T3i OH450 N S Q1a a bond H a bond NH S NH T3j OH 451 N S Q1a a bond H a bondNH S a bond T3a OH 452 N S Q1a a bond H a bond NH S a bond T3b OH 453 NS Q1a a bond H a bond NH S a bond T3c OH 454 N S Q1a a bond H a bond NHS a bond T3d OH 455 N S Q1a a bond H a bond NH S a bond T3e OH 456 N SQ1a a bond H a bond NH S a bond T3f OH 457 N S Q1a a bond H a bond NH Sa bond T3g OH 458 N S Q1a a bond H a bond NH S a bond T3h OH 459 N S Q1aa bond H a bond NH S a bond T3i OH 460 N S Q1a a bond H a bond NH S abond T3j OH 461 N S Q1a a bond H a bond NH O NH T3a OH 462 N S Q1a abond H a bond NH O NH T3b OH 463 N S Q1a a bond H a bond NH O NH T3c OH464 N S Q1a a bond H a bond NH O NH T3d OH 465 N S Q1a a bond H a bondNH O NH T3e OH 466 N S Q1a a bond H a bond NH O NH T3f OH 467 N S Q1a abond H a bond NH O NH T3g OH 468 N S Q1a a bond H a bond NH O NH T3h OH469 N S Q1a a bond H a bond NH O NH T3i OH 470 N S Q1a a bond H a bondNH O NH T3j OH 471 N S Q1a a bond H a bond NH O a bond T3a OH 472 N SQ1a a bond H a bond NH O a bond T3b OH 473 N S Q1a a bond H a bond NH Oa bond T3c OH 474 N S Q1a a bond H a bond NH O a bond T3d OH 475 N S Q1aa bond H a bond NH O a bond T3e OH 476 N S Q1a a bond H a bond NH O abond T3f OH 477 N S Q1a a bond H a bond NH O a bond T3g OH 478 N S Q1a abond H a bond NH O a bond T3h OH 479 N S Q1a a bond H a bond NH O a bondT3i OH 480 N S Q1a a bond H a bond NH O a bond T3j OH 481 N S Q1b a bondMe a bond NH S NH T3a OH 482 N S Q1b a bond Me a bond NH S NH T3b OH 483N S Q1b a bond Me a bond NH S NH T3c OH 484 N S Q1b a bond Me a bond NHS NH T3d OH 485 N S Q1b a bond Me a bond NH S NH T3e OH 486 N S Q1b abond Me a bond NH S NH T3f OH 487 N S Q1b a bond Me a bond NH S NH T3gOH 488 N S Q1b a bond Me a bond NH S NH T3h OH 489 N S Q1b a bond Me abond NH S NH T3i OH 490 N S Q1b a bond Me a bond NH S NH T3j OH 491 N SQ1b a bond Me a bond NH S a bond T3a OH 492 N S Q1b a bond Me a bond NHS a bond T3b OH 493 N S Q1b a bond Me a bond NH S a bond T3c OH 494 N SQ1b a bond Me a bond NH S a bond T3d OH 495 N S Q1b a bond Me a bond NHS a bond T3e OH 496 N S Q1b a bond Me a bond NH S a bond T3f OH 497 N SQ1b a bond Me a bond NH S a bond T3g OH 498 N S Q1b a bond Me a bond NHS a bond T3h OH 499 N S Q1b a bond Me a bond NH S a bond T3i OH 500 N SQ1b a bond Me a bond NH S a bond T3j OH 501 N S Q1b a bond Me a bond NHO NH T3a OH 502 N S Q1b a bond Me a bond NH O NH T3b OH 503 N S Q1b abond Me a bond NH O NH T3c OH 504 N S Q1b a bond Me a bond NH O NH T3dOH 505 N S Q1b a bond Me a bond NH O NH T3e OH 506 N S Q1b a bond Me abond NH O NH T3f OH 507 N S Q1b a bond Me a bond NH O NH T3g OH 508 N SQ1b a bond Me a bond NH O NH T3h OH 509 N S Q1b a bond Me a bond NH O NHT3i OH 510 N S Q1b a bond Me a bond NH O NH T3j OH 511 N S Q1b a bond Mea bond NH O a bond T3a OH 512 N S Q1b a bond Me a bond NH O a bond T3bOH 513 N S Q1b a bond Me a bond NH O a bond T3c OH 514 N S Q1b a bond Mea bond NH O a bond T3d OH 515 N S Q1b a bond Me a bond NH O a bond T3eOH 516 N S Q1b a bond Me a bond NH O a bond T3f OH 517 N S Q1b a bond Mea bond NH O a bond T3g OH 518 N S Q1b a bond Me a bond NH O a bond T3hOH 519 N S Q1b a bond Me a bond NH O a bond T3i OH 520 N S Q1b a bond Mea bond NH O a bond T3j OH 521 N S Q1b a bond H a bond NH S NH T3a OH 522N S Q1b a bond H a bond NH S NH T3b OH 523 N S Q1b a bond H a bond NH SNH T3c OH 524 N S Q1b a bond H a bond NH S NH T3d OH 525 N S Q1b a bondH a bond NH S NH T3e OH 526 N S Q1b a bond H a bond NH S NH T3f OH 527 NS Q1b a bond H a bond NH S NH T3g OH 528 N S Q1b a bond H a bond NH S NHT3h OH 529 N S Q1b a bond H a bond NH S NH T3i OH 530 N S Q1b a bond H abond NH S NH T3j OH 531 N S Q1b a bond H a bond NH S a bond T3a OH 532 NS Q1b a bond H a bond NH S a bond T3b OH 533 N S Q1b a bond H a bond NHS a bond T3c OH 534 N S Q1b a bond H a bond NH S a bond T3d OH 535 N SQ1b a bond H a bond NH S a bond T3e OH 536 N S Q1b a bond H a bond NH Sa bond T3f OH 537 N S Q1b a bond H a bond NH S a bond T3g OH 538 N S Q1ba bond H a bond NH S a bond T3h OH 539 N S Q1b a bond H a bond NH S abond T3i OH 540 N S Q1b a bond H a bond NH S a bond T3j OH 541 N S Q1b abond H a bond NH O NH T3a OH 542 N S Q1b a bond H a bond NH O NH T3b OH543 N S Q1b a bond H a bond NH O NH T3c OH 544 N S Q1b a bond H a bondNH O NH T3d OH 545 N S Q1b a bond H a bond NH O NH T3e OH 546 N S Q1b abond H a bond NH O NH T3f OH 547 N S Q1b a bond H a bond NH O NH T3g OH548 N S Q1b a bond H a bond NH O NH T3h OH 549 N S Q1b a bond H a bondNH O NH T3i OH 550 N S Q1b a bond H a bond NH O NH T3j OH 551 N S Q1b abond H a bond NH O a bond T3a OH 552 N S Q1b a bond H a bond NH O a bondT3b OH 553 N S Q1b a bond H a bond NH O a bond T3c OH 554 N S Q1b a bondH a bond NH O a bond T3d OH 555 N S Q1b a bond H a bond NH O a bond T3eOH 556 N S Q1b a bond H a bond NH O a bond T3f OH 557 N S Q1b a bond H abond NH O a bond T3g OH 558 N S Q1b a bond H a bond NH O a bond T3h OH559 N S Q1b a bond H a bond NH O a bond T3i OH 560 N S Q1b a bond H abond NH O a bond T3j OH 561 N S Q1c a bond Me a bond NH S NH T3a OH 562N S Q1c a bond Me a bond NH S NH T3b OH 563 N S Q1c a bond Me a bond NHS NH T3c OH 564 N S Q1c a bond Me a bond NH S NH T3d OH 565 N S Q1c abond Me a bond NH S NH T3e OH 566 N S Q1c a bond Me a bond NH S NH T3fOH 567 N S Q1c a bond Me a bond NH S NH T3g OH 568 N S Q1c a bond Me abond NH S NH T3h OH 569 N S Q1c a bond Me a bond NH S NH T3i OH 570 N SQ1c a bond Me a bond NH S NH T3j OH 571 N S Q1c a bond Me a bond NH S abond T3a OH 572 N S Q1c a bond Me a bond NH S a bond T3b OH 573 N S Q1ca bond Me a bond NH S a bond T3c OH 574 N S Q1c a bond Me a bond NH S abond T3d OH 575 N S Q1c a bond Me a bond NH S a bond T3e OH 576 N S Q1ca bond Me a bond NH S a bond T3f OH 577 N S Q1c a bond Me a bond NH S abond T3g OH 578 N S Q1c a bond Me a bond NH S a bond T3h OH 579 N S Q1ca bond Me a bond NH S a bond T3i OH 580 N S Q1c a bond Me a bond NH S abond T3j OH 581 N S Q1c a bond Me a bond NH O NH T3a OH 582 N S Q1c abond Me a bond NH O NH T3b OH 583 N S Q1c a bond Me a bond NH O NH T3cOH 584 N S Q1c a bond Me a bond NH O NH T3d OH 585 N S Q1c a bond Me abond NH O NH T3e OH 586 N S Q1c a bond Me a bond NH O NH T3f OH 587 N SQ1c a bond Me a bond NH O NH T3g OH 588 N S Q1c a bond Me a bond NH O NHT3h OH 589 N S Q1c a bond Me a bond NH O NH T3i OH 590 N S Q1c a bond Mea bond NH O NH T3j OH 591 N S Q1c a bond Me a bond NH O a bond T3a OH592 N S Q1c a bond Me a bond NH O a bond T3b OH 593 N S Q1c a bond Me abond NH O a bond T3c OH 594 N S Q1c a bond Me a bond NH O a bond T3d OH595 N S Q1c a bond Me a bond NH O a bond T3e OH 596 N S Q1c a bond Me abond NH O a bond T3f OH 597 N S Q1c a bond Me a bond NH O a bond T3g OH598 N S Q1c a bond Me a bond NH O a bond T3h OH 599 N S Q1c a bond Me abond NH O a bond T3i OH 600 N S Q1c a bond Me a bond NH O a bond T3j OH601 N S Q1c a bond H a bond NH S NH T3a OH 602 N S Q1c a bond H a bondNH S NH T3b OH 603 N S Q1c a bond H a bond NH S NH T3c OH 604 N S Q1c abond H a bond NH S NH T3d OH 605 N S Q1c a bond H a bond NH S NH T3e OH606 N S Q1c a bond H a bond NH S NH T3f OH 607 N S Q1c a bond H a bondNH S NH T3g OH 608 N S Q1c a bond H a bond NH S NH T3h OH 609 N S Q1c abond H a bond NH S NH T3i OH 610 N S Q1c a bond H a bond NH S NH T3j OH611 N S Q1c a bond H a bond NH S a bond T3a OH 612 N S Q1c a bond H abond NH S a bond T3b OH 613 N S Q1c a bond H a bond NH S a bond T3c OH614 N S Q1c a bond H a bond NH S a bond T3d OH 615 N S Q1c a bond H abond NH S a bond T3e OH 616 N S Q1c a bond H a bond NH S a bond T3f OH617 N S Q1c a bond H a bond NH S a bond T3g OH 618 N S Q1c a bond H abond NH S a bond T3h OH 619 N S Q1c a bond H a bond NH S a bond T3i OH620 N S Q1c a bond H a bond NH S a bond T3j OH 621 N S Q1c a bond H abond NH O NH T3a OH 622 N S Q1c a bond H a bond NH O NH T3b OH 623 N SQ1c a bond H a bond NH O NH T3c OH 624 N S Q1c a bond H a bond NH O NHT3d OH 625 N S Q1c a bond H a bond NH O NH T3e OH 626 N S Q1c a bond H abond NH O NH T3f OH 627 N S Q1c a bond H a bond NH O NH T3g OH 628 N SQ1c a bond H a bond NH O NH T3h OH 629 N S Q1c a bond H a bond NH O NHT3i OH 630 N S Q1c a bond H a bond NH O NH T3j OH 631 N S Q1c a bond H abond NH O a bond T3a OH 632 N S Q1c a bond H a bond NH O a bond T3b OH633 N S Q1c a bond H a bond NH O a bond T3c OH 634 N S Q1c a bond H abond NH O a bond T3d OH 635 N S Q1c a bond H a bond NH O a bond T3e OH636 N S Q1c a bond H a bond NH O a bond T3f OH 637 N S Q1c a bond H abond NH O a bond T3g OH 638 N S Q1c a bond H a bond NH O a bond T3h OH639 N S Q1c a bond H a bond NH O a bond T3i OH 640 N S Q1c a bond H abond NH O a bond T3j OH 641 N S Q1i a bond Me a bond NH S NH T3a OH 642N S Q1i a bond Me a bond NH S NH T3b OH 643 N S Q1i a bond Me a bond NHS NH T3c OH 644 N S Q1i a bond Me a bond NH S NH T3d OH 645 N S Q1i abond Me a bond NH S NH T3e OH 646 N S Q1i a bond Me a bond NH S NH T3fOH 647 N S Q1i a bond Me a bond NH S NH T3g OH 648 N S Q1i a bond Me abond NH S NH T3h OH 649 N S Q1i a bond Me a bond NH S NH T3i OH 650 N SQ1i a bond Me a bond NH S NH T3j OH 651 N S Q1i a bond Me a bond NH S abond T3a OH 652 N S Q1i a bond Me a bond NH S a bond T3b OH 653 N S Q1ia bond Me a bond NH S a bond T3c OH 654 N S Q1i a bond Me a bond NH S abond T3d OH 655 N S Q1i a bond Me a bond NH S a bond T3e OH 656 N S Q1ia bond Me a bond NH S a bond T3f OH 657 N S Q1i a bond Me a bond NH S abond T3g OH 658 N S Q1i a bond Me a bond NH S a bond T3h OH 659 N S Q1ia bond Me a bond NH S a bond T3i OH 660 N S Q1i a bond Me a bond NH S abond T3j OH 661 N S Q1i a bond Me a bond NH O NH T3a OH 662 N S Q1i abond Me a bond NH O NH T3b OH 663 N S Q1i a bond Me a bond NH O NH T3cOH 664 N S Q1i a bond Me a bond NH O NH T3d OH 665 N S Q1i a bond Me abond NH O NH T3e OH 666 N S Q1i a bond Me a bond NH O NH T3f OH 667 N SQ1i a bond Me a bond NH O NH T3g OH 668 N S Q1i a bond Me a bond NH O NHT3h OH 669 N S Q1i a bond Me a bond NH O NH T3i OH 670 N S Q1i a bond Mea bond NH O NH T3j OH 671 N S Q1i a bond Me a bond NH O a bond T3a OH672 N S Q1i a bond Me a bond NH O a bond T3b OH 673 N S Q1i a bond Me abond NH O a bond T3c OH 674 N S Q1i a bond Me a bond NH O a bond T3d OH675 N S Q1i a bond Me a bond NH O a bond T3e OH 676 N S Q1i a bond Me abond NH O a bond T3f OH 677 N S Q1i a bond Me a bond NH O a bond T3g OH678 N S Q1i a bond Me a bond NH O a bond T3h OH 679 N S Q1i a bond Me abond NH O a bond T3i OH 680 N S Q1i a bond Me a bond NH O a bond T3j OH681 N S Q1i a bond H a bond NH S NH T3a OH 682 N S Q1i a bond H a bondNH S NH T3b OH 683 N S Q1i a bond H a bond NH S NH T3c OH 684 N S Q1i abond H a bond NH S NH T3d OH 685 N S Q1i a bond H a bond NH S NH T3e OH686 N S Q1i a bond H a bond NH S NH T3f OH 687 N S Q1i a bond H a bondNH S NH T3g OH 688 N S Q1i a bond H a bond NH S NH T3h OH 689 N S Q1i abond H a bond NH S NH T3i OH 690 N S Q1i a bond H a bond NH S NH T3j OH691 N S Q1i a bond H a bond NH S a bond T3a OH 692 N S Q1i a bond H abond NH S a bond T3b OH 693 N S Q1i a bond H a bond NH S a bond T3c OH694 N S Q1i a bond H a bond NH S a bond T3d OH 695 N S Q1i a bond H abond NH S a bond T3e OH 696 N S Q1i a bond H a bond NH S a bond T3f OH697 N S Q1i a bond H a bond NH S a bond T3g OH 698 N S Q1i a bond H abond NH S a bond T3h OH 699 N S Q1i a bond H a bond NH S a bond T3i OH700 N S Q1i a bond H a bond NH S a bond T3j OH 701 N S Q1i a bond H abond NH O NH T3a OH 702 N S Q1i a bond H a bond NH O NH T3b OH 703 N SQ1i a bond H a bond NH O NH T3c OH 704 N S Q1i a bond H a bond NH O NHT3d OH 705 N S Q1i a bond H a bond NH O NH T3e OH 706 N S Q1i a bond H abond NH O NH T3f OH 707 N S Q1i a bond H a bond NH O NH T3g OH 708 N SQ1i a bond H a bond NH O NH T3h OH 709 N S Q1i a bond H a bond NH O NHT3i OH 710 N S Q1i a bond H a bond NH O NH T3j OH 711 N S Q1i a bond H abond NH O a bond T3a OH 712 N S Q1i a bond H a bond NH O a bond T3b OH713 N S Q1i a bond H a bond NH O a bond T3c OH 714 N S Q1i a bond H abond NH O a bond T3d OH 715 N S Q1i a bond H a bond NH O a bond T3e OH716 N S Q1i a bond H a bond NH O a bond T3f OH 717 N S Q1i a bond H abond NH O a bond T3g OH 718 N S Q1i a bond H a bond NH O a bond T3h OH719 N S Q1i a bond H a bond NH O a bond T3i OH 720 N S Q1i a bond H abond NH O a bond T3j OH 721 N S Q1j a bond Me a bond NH S NH T3a OH 722N S Q1j a bond Me a bond NH S NH T3b OH 723 N S Q1j a bond Me a bond NHS NH T3c OH 724 N S Q1j a bond Me a bond NH S NH T3d OH 725 N S Q1j abond Me a bond NH S NH T3e OH 726 N S Q1j a bond Me a bond NH S NH T3fOH 727 N S Q1j a bond Me a bond NH S NH T3g OH 728 N S Q1j a bond Me abond NH S NH T3h OH 729 N S Q1j a bond Me a bond NH S NH T3i OH 730 N SQ1j a bond Me a bond NH S NH T3j OH 731 N S Q1j a bond Me a bond NH S abond T3a OH 732 N S Q1j a bond Me a bond NH S a bond T3b OH 733 N S Q1ja bond Me a bond NH S a bond T3c OH 734 N S Q1j a bond Me a bond NH S abond T3d OH 735 N S Q1j a bond Me a bond NH S a bond T3e OH 736 N S Q1ja bond Me a bond NH S a bond T3f OH 737 N S Q1j a bond Me a bond NH S abond T3g OH 738 N S Q1j a bond Me a bond NH S a bond T3h OH 739 N S Q1ja bond Me a bond NH S a bond T3i OH 740 N S Q1j a bond Me a bond NH S abond T3j OH 741 N S Q1j a bond Me a bond NH O NH T3a OH 742 N S Q1j abond Me a bond NH O NH T3b OH 743 N S Q1j a bond Me a bond NH O NH T3cOH 744 N S Q1j a bond Me a bond NH O NH T3d OH 745 N S Q1j a bond Me abond NH O NH T3e OH 746 N S Q1j a bond Me a bond NH O NH T3f OH 747 N SQ1j a bond Me a bond NH O NH T3g OH 748 N S Q1j a bond Me a bond NH O NHT3h OH 749 N S Q1j a bond Me a bond NH O NH T3i OH 750 N S Q1j a bond Mea bond NH O NH T3j OH 751 N S Q1j a bond Me a bond NH O a bond T3a OH752 N S Q1j a bond Me a bond NH O a bond T3b OH 753 N S Q1j a bond Me abond NH O a bond T3c OH 754 N S Q1j a bond Me a bond NH O a bond T3d OH755 N S Q1j a bond Me a bond NH O a bond T3e OH 756 N S Q1j a bond Me abond NH O a bond T3f OH 757 N S Q1j a bond Me a bond NH O a bond T3g OH758 N S Q1j a bond Me a bond NH O a bond T3h OH 759 N S Q1j a bond Me abond NH O a bond T3i OH 760 N S Q1j a bond Me a bond NH O a bond T3j OH761 N S Q1j a bond H a bond NH S NH T3a OH 762 N S Q1j a bond H a bondNH S NH T3b OH 763 N S Q1j a bond H a bond NH S NH T3c OH 764 N S Q1j abond H a bond NH S NH T3d OH 765 N S Q1j a bond H a bond NH S NH T3e OH766 N S Q1j a bond H a bond NH S NH T3f OH 767 N S Q1j a bond H a bondNH S NH T3g OH 768 N S Q1j a bond H a bond NH S NH T3h OH 769 N S Q1j abond H a bond NH S NH T3i OH 770 N S Q1j a bond H a bond NH S NH T3j OH771 N S Q1j a bond H a bond NH S a bond T3a OH 772 N S Q1j a bond H abond NH S a bond T3b OH 773 N S Q1j a bond H a bond NH S a bond T3c OH774 N S Q1j a bond H a bond NH S a bond T3d OH 775 N S Q1j a bond H abond NH S a bond T3e OH 776 N S Q1j a bond H a bond NH S a bond T3f OH777 N S Q1j a bond H a bond NH S a bond T3g OH 778 N S Q1j a bond H abond NH S a bond T3h OH 779 N S Q1j a bond H a bond NH S a bond T3i OH780 N S Q1j a bond H a bond NH S a bond T3j OH 781 N S Q1j a bond H abond NH O NH T3a OH 782 N S Q1j a bond H a bond NH O NH T3b OH 783 N SQ1j a bond H a bond NH O NH T3c OH 784 N S Q1j a bond H a bond NH O NHT3d OH 785 N S Q1j a bond H a bond NH O NH T3e OH 786 N S Q1j a bond H abond NH O NH T3f OH 787 N S Q1j a bond H a bond NH O NH T3g OH 788 N SQ1j a bond H a bond NH O NH T3h OH 789 N S Q1j a bond H a bond NH O NHT3i OH 790 N S Q1j a bond H a bond NH O NH T3j OH 791 N S Q1j a bond H abond NH O a bond T3a OH 792 N S Q1j a bond H a bond NH O a bond T3b OH793 N S Q1j a bond H a bond NH O a bond T3c OH 794 N S Q1j a bond H abond NH O a bond T3d OH 795 N S Q1j a bond H a bond NH O a bond T3e OH796 N S Q1j a bond H a bond NH O a bond T3f OH 797 N S Q1j a bond H abond NH O a bond T3g OH 798 N S Q1j a bond H a bond NH O a bond T3h OH799 N S Q1j a bond H a bond NH O a bond T3i OH 800 N S Q1j a bond H abond NH O a bond T3j OH 801 N O Q1a a bond Me a bond NH S NH T3a OH 802N O Q1a a bond Me a bond NH S NH T3b OH 803 N O Q1a a bond Me a bond NHS NH T3c OH 804 N O Q1a a bond Me a bond NH S NH T3d OH 805 N O Q1a abond Me a bond NH S NH T3e OH 806 N O Q1a a bond Me a bond NH S NH T3fOH 807 N O Q1a a bond Me a bond NH S NH T3g OH 808 N O Q1a a bond Me abond NH S NH T3h OH 809 N O Q1a a bond Me a bond NH S NH T3i OH 810 N OQ1a a bond Me a bond NH S NH T3j OH 811 N O Q1a a bond Me a bond NH S abond T3a OH 812 N O Q1a a bond Me a bond NH S a bond T3b OH 813 N O Q1aa bond Me a bond NH S a bond T3c OH 814 N O Q1a a bond Me a bond NH S abond T3d OH 815 N O Q1a a bond Me a bond NH S a bond T3e OH 816 N O Q1aa bond Me a bond NH S a bond T3f OH 817 N O Q1a a bond Me a bond NH S abond T3g OH 818 N O Q1a a bond Me a bond NH S a bond T3h OH 819 N O Q1aa bond Me a bond NH S a bond T3i OH 820 N O Q1a a bond Me a bond NH S abond T3j OH 821 N O Q1a a bond Me a bond NH O NH T3a OH 822 N O Q1a abond Me a bond NH O NH T3b OH 823 N O Q1a a bond Me a bond NH O NH T3cOH 824 N O Q1a a bond Me a bond NH O NH T3d OH 825 N O Q1a a bond Me abond NH O NH T3e OH 826 N O Q1a a bond Me a bond NH O NH T3f OH 827 N OQ1a a bond Me a bond NH O NH T3g OH 828 N O Q1a a bond Me a bond NH O NHT3h OH 829 N O Q1a a bond Me a bond NH O NH T3i OH 830 N O Q1a a bond Mea bond NH O NH T3j OH 831 N O Q1a a bond Me a bond NH O a bond T3a OH832 N O Q1a a bond Me a bond NH O a bond T3b OH 833 N O Q1a a bond Me abond NH O a bond T3c OH 834 N O Q1a a bond Me a bond NH O a bond T3d OH835 N O Q1a a bond Me a bond NH O a bond T3e OH 836 N O Q1a a bond Me abond NH O a bond T3f OH 837 N O Q1a a bond Me a bond NH O a bond T3g OH838 N O Q1a a bond Me a bond NH O a bond T3h OH 839 N O Q1a a bond Me abond NH O a bond T3i OH 840 N O Q1a a bond Me a bond NH O a bond T3j OH841 N O Q1a a bond H a bond NH S NH T3a OH 842 N O Q1a a bond H a bondNH S NH T3b OH 843 N O Q1a a bond H a bond NH S NH T3c OH 844 N O Q1a abond H a bond NH S NH T3d OH 845 N O Q1a a bond H a bond NH S NH T3e OH846 N O Q1a a bond H a bond NH S NH T3f OH 847 N O Q1a a bond H a bondNH S NH T3g OH 848 N O Q1a a bond H a bond NH S NH T3h OH 849 N O Q1a abond H a bond NH S NH T3i OH 850 N O Q1a a bond H a bond NH S NH T3j OH851 N O Q1a a bond H a bond NH S a bond T3a OH 852 N O Q1a a bond H abond NH S a bond T3b OH 853 N O Q1a a bond H a bond NH S a bond T3c OH854 N O Q1a a bond H a bond NH S a bond T3d OH 855 N O Q1a a bond H abond NH S a bond T3e OH 856 N O Q1a a bond H a bond NH S a bond T3f OH857 N O Q1a a bond H a bond NH S a bond T3g OH 858 N O Q1a a bond H abond NH S a bond T3h OH 859 N O Q1a a bond H a bond NH S a bond T3i OH860 N O Q1a a bond H a bond NH S a bond T3j OH 861 N O Q1a a bond H abond NH O NH T3a OH 862 N O Q1a a bond H a bond NH O NH T3b OH 863 N OQ1a a bond H a bond NH O NH T3c OH 864 N O Q1a a bond H a bond NH O NHT3d OH 865 N O Q1a a bond H a bond NH O NH T3e OH 866 N O Q1a a bond H abond NH O NH T3f OH 867 N O Q1a a bond H a bond NH O NH T3g OH 868 N OQ1a a bond H a bond NH O NH T3h OH 869 N O Q1a a bond H a bond NH O NHT3i OH 870 N O Q1a a bond H a bond NH O NH T3j OH 871 N O Q1a a bond H abond NH O a bond T3a OH 872 N O Q1a a bond H a bond NH O a bond T3b OH873 N O Q1a a bond H a bond NH O a bond T3c OH 874 N O Q1a a bond H abond NH O a bond T3d OH 875 N O Q1a a bond H a bond NH O a bond T3e OH876 N O Q1a a bond H a bond NH O a bond T3f OH 877 N O Q1a a bond H abond NH O a bond T3g OH 878 N O Q1a a bond H a bond NH O a bond T3h OH879 N O Q1a a bond H a bond NH O a bond T3i OH 880 N O Q1a a bond H abond NH O a bond T3j OH 881 N O Q1b a bond Me a bond NH S NH T3a OH 882N O Q1b a bond Me a bond NH S NH T3b OH 883 N O Q1b a bond Me a bond NHS NH T3c OH 884 N O Q1b a bond Me a bond NH S NH T3d OH 885 N O Q1b abond Me a bond NH S NH T3e OH 886 N O Q1b a bond Me a bond NH S NH T3fOH 887 N O Q1b a bond Me a bond NH S NH T3g OH 888 N O Q1b a bond Me abond NH S NH T3h OH 889 N O Q1b a bond Me a bond NH S NH T3i OH 890 N OQ1b a bond Me a bond NH S NH T3j OH 891 N O Q1b a bond Me a bond NH S abond T3a OH 892 N O Q1b a bond Me a bond NH S a bond T3b OH 893 N O Q1ba bond Me a bond NH S a bond T3c OH 894 N O Q1b a bond Me a bond NH S abond T3d OH 895 N O Q1b a bond Me a bond NH S a bond T3e OH 896 N O Q1ba bond Me a bond NH S a bond T3f OH 897 N O Q1b a bond Me a bond NH S abond T3g OH 898 N O Q1b a bond Me a bond NH S a bond T3h OH 899 N O Q1ba bond Me a bond NH S a bond T3i OH 900 N O Q1b a bond Me a bond NH S abond T3j OH 901 N O Q1b a bond Me a bond NH O NH T3a OH 902 N O Q1b abond Me a bond NH O NH T3b OH 903 N O Q1b a bond Me a bond NH O NH T3cOH 904 N O Q1b a bond Me a bond NH O NH T3d OH 905 N O Q1b a bond Me abond NH O NH T3e OH 906 N O Q1b a bond Me a bond NH O NH T3f OH 907 N OQ1b a bond Me a bond NH O NH T3g OH 908 N O Q1b a bond Me a bond NH O NHT3h OH 909 N O Q1b a bond Me a bond NH O NH T3i OH 910 N O Q1b a bond Mea bond NH O NH T3j OH 911 N O Q1b a bond Me a bond NH O a bond T3a OH912 N O Q1b a bond Me a bond NH O a bond T3b OH 913 N O Q1b a bond Me abond NH O a bond T3c OH 914 N O Q1b a bond Me a bond NH O a bond T3d OH915 N O Q1b a bond Me a bond NH O a bond T3e OH 916 N O Q1b a bond Me abond NH O a bond T3f OH 917 N O Q1b a bond Me a bond NH O a bond T3g OH918 N O Q1b a bond Me a bond NH O a bond T3h OH 919 N O Q1b a bond Me abond NH O a bond T3i OH 920 N O Q1b a bond Me a bond NH O a bond T3j OH921 N O Q1b a bond H a bond NH S NH T3a OH 922 N O Q1b a bond H a bondNH S NH T3b OH 923 N O Q1b a bond H a bond NH S NH T3c OH 924 N O Q1b abond H a bond NH S NH T3d OH 925 N O Q1b a bond H a bond NH S NH T3e OH926 N O Q1b a bond H a bond NH S NH T3f OH 927 N O Q1b a bond H a bondNH S NH T3g OH 928 N O Q1b a bond H a bond NH S NH T3h OH 929 N O Q1b abond H a bond NH S NH T3i OH 930 N O Q1b a bond H a bond NH S NH T3j OH931 N O Q1b a bond H a bond NH S a bond T3a OH 932 N O Q1b a bond H abond NH S a bond T3b OH 933 N O Q1b a bond H a bond NH S a bond T3c OH934 N O Q1b a bond H a bond NH S a bond T3d OH 935 N O Q1b a bond H abond NH S a bond T3e OH 936 N O Q1b a bond H a bond NH S a bond T3f OH937 N O Q1b a bond H a bond NH S a bond T3g OH 938 N O Q1b a bond H abond NH S a bond T3h OH 939 N O Q1b a bond H a bond NH S a bond T3i OH940 N O Q1b a bond H a bond NH S a bond T3j OH 941 N O Q1b a bond H abond NH O NH T3a OH 942 N O Q1b a bond H a bond NH O NH T3b OH 943 N OQ1b a bond H a bond NH O NH T3c OH 944 N O Q1b a bond H a bond NH O NHT3d OH 945 N O Q1b a bond H a bond NH O NH T3e OH 946 N O Q1b a bond H abond NH O NH T3f OH 947 N O Q1b a bond H a bond NH O NH T3g OH 948 N OQ1b a bond H a bond NH O NH T3h OH 949 N O Q1b a bond H a bond NH O NHT3i OH 950 N O Q1b a bond H a bond NH O NH T3j OH 951 N O Q1b a bond H abond NH O a bond T3a OH 952 N O Q1b a bond H a bond NH O a bond T3b OH953 N O Q1b a bond H a bond NH O a bond T3c OH 954 N O Q1b a bond H abond NH O a bond T3d OH 955 N O Q1b a bond H a bond NH O a bond T3e OH956 N O Q1b a bond H a bond NH O a bond T3f OH 957 N O Q1b a bond H abond NH O a bond T3g OH 958 N O Q1b a bond H a bond NH O a bond T3h OH959 N O Q1b a bond H a bond NH O a bond T3i OH 960 N O Q1b a bond H abond NH O a bond T3j OH 961 N O Q1c a bond Me a bond NH S NH T3a OH 962N O Q1c a bond Me a bond NH S NH T3b OH 963 N O Q1c a bond Me a bond NHS NH T3c OH 964 N O Q1c a bond Me a bond NH S NH T3d OH 965 N O Q1c abond Me a bond NH S NH T3e OH 966 N O Q1c a bond Me a bond NH S NH T3fOH 967 N O Q1c a bond Me a bond NH S NH T3g OH 968 N O Q1c a bond Me abond NH S NH T3h OH 969 N O Q1c a bond Me a bond NH S NH T3i OH 970 N OQ1c a bond Me a bond NH S NH T3j OH 971 N O Q1c a bond Me a bond NH S abond T3a OH 972 N O Q1c a bond Me a bond NH S a bond T3b OH 973 N O Q1ca bond Me a bond NH S a bond T3c OH 974 N O Q1c a bond Me a bond NH S abond T3d OH 975 N O Q1c a bond Me a bond NH S a bond T3e OH 976 N O Q1ca bond Me a bond NH S a bond T3f OH 977 N O Q1c a bond Me a bond NH S abond T3g OH 978 N O Q1c a bond Me a bond NH S a bond T3h OH 979 N O Q1ca bond Me a bond NH S a bond T3i OH 980 N O Q1c a bond Me a bond NH S abond T3j OH 981 N O Q1c a bond Me a bond NH O NH T3a OH 982 N O Q1c abond Me a bond NH O NH T3b OH 983 N O Q1c a bond Me a bond NH O NH T3cOH 984 N O Q1c a bond Me a bond NH O NH T3d OH 985 N O Q1c a bond Me abond NH O NH T3e OH 986 N O Q1c a bond Me a bond NH O NH T3f OH 987 N OQ1c a bond Me a bond NH O NH T3g OH 988 N O Q1c a bond Me a bond NH O NHT3h OH 989 N O Q1c a bond Me a bond NH O NH T3i OH 990 N O Q1c a bond Mea bond NH O NH T3j OH 991 N O Q1c a bond Me a bond NH O a bond T3a OH992 N O Q1c a bond Me a bond NH O a bond T3b OH 993 N O Q1c a bond Me abond NH O a bond T3c OH 994 N O Q1c a bond Me a bond NH O a bond T3d OH995 N O Q1c a bond Me a bond NH O a bond T3e OH 996 N O Q1c a bond Me abond NH O a bond T3f OH 997 N O Q1c a bond Me a bond NH O a bond T3g OH998 N O Q1c a bond Me a bond NH O a bond T3h OH 999 N O Q1c a bond Me abond NH O a bond T3i OH 1000 N O Q1c a bond Me a bond NH O a bond T3j OH1001 N O Q1c a bond H a bond NH S NH T3a OH 1002 N O Q1c a bond H a bondNH S NH T3b OH 1003 N O Q1c a bond H a bond NH S NH T3c OH 1004 N O Q1ca bond H a bond NH S NH T3d OH 1005 N O Q1c a bond H a bond NH S NH T3eOH 1006 N O Q1c a bond H a bond NH S NH T3f OH 1007 N O Q1c a bond H abond NH S NH T3g OH 1008 N O Q1c a bond H a bond NH S NH T3h OH 1009 N OQ1c a bond H a bond NH S NH T3i OH 1010 N O Q1c a bond H a bond NH S NHT3j OH 1011 N O Q1c a bond H a bond NH S a bond T3a OH 1012 N O Q1c abond H a bond NH S a bond T3b OH 1013 N O Q1c a bond H a bond NH S abond T3c OH 1014 N O Q1c a bond H a bond NH S a bond T3d OH 1015 N O Q1ca bond H a bond NH S a bond T3e OH 1016 N O Q1c a bond H a bond NH S abond T3f OH 1017 N O Q1c a bond H a bond NH S a bond T3g OH 1018 N O Q1ca bond H a bond NH S a bond T3h OH 1019 N O Q1c a bond H a bond NH S abond T3i OH 1020 N O Q1c a bond H a bond NH S a bond T3j OH 1021 N O Q1ca bond H a bond NH O NH T3a OH 1022 N O Q1c a bond H a bond NH O NH T3bOH 1023 N O Q1c a bond H a bond NH O NH T3c OH 1024 N O Q1c a bond H abond NH O NH T3d OH 1025 N O Q1c a bond H a bond NH O NH T3e OH 1026 N OQ1c a bond H a bond NH O NH T3f OH 1027 N O Q1c a bond H a bond NH O NHT3g OH 1028 N O Q1c a bond H a bond NH O NH T3h OH 1029 N O Q1c a bond Ha bond NH O NH T3i OH 1030 N O Q1c a bond H a bond NH O NH T3j OH 1031 NO Q1c a bond H a bond NH O a bond T3a OH 1032 N O Q1c a bond H a bond NHO a bond T3b OH 1033 N O Q1c a bond H a bond NH O a bond T3c OH 1034 N OQ1c a bond H a bond NH O a bond T3d OH 1035 N O Q1c a bond H a bond NH Oa bond T3e OH 1036 N O Q1c a bond H a bond NH O a bond T3f OH 1037 N OQ1c a bond H a bond NH O a bond T3g OH 1038 N O Q1c a bond H a bond NH Oa bond T3h OH 1039 N O Q1c a bond H a bond NH O a bond T3i OH 1040 N OQ1c a bond H a bond NH O a bond T3j OH 1041 N O Q1i a bond Me a bond NHS NH T3a OH 1042 N O Q1i a bond Me a bond NH S NH T3b OH 1043 N O Q1i abond Me a bond NH S NH T3c OH 1044 N O Q1i a bond Me a bond NH S NH T3dOH 1045 N O Q1i a bond Me a bond NH S NH T3e OH 1046 N O Q1i a bond Me abond NH S NH T3f OH 1047 N O Q1i a bond Me a bond NH S NH T3g OH 1048 NO Q1i a bond Me a bond NH S NH T3h OH 1049 N O Q1i a bond Me a bond NH SNH T3i OH 1050 N O Q1i a bond Me a bond NH S NH T3j OH 1051 N O Q1i abond Me a bond NH S a bond T3a OH 1052 N O Q1i a bond Me a bond NH S abond T3b OH 1053 N O Q1i a bond Me a bond NH S a bond T3c OH 1054 N OQ1i a bond Me a bond NH S a bond T3d OH 1055 N O Q1i a bond Me a bond NHS a bond T3e OH 1056 N O Q1i a bond Me a bond NH S a bond T3f OH 1057 NO Q1i a bond Me a bond NH S a bond T3g OH 1058 N O Q1i a bond Me a bondNH S a bond T3h OH 1059 N O Q1i a bond Me a bond NH S a bond T3i OH 1060N O Q1i a bond Me a bond NH S a bond T3j OH 1061 N O Q1i a bond Me abond NH O NH T3a OH 1062 N O Q1i a bond Me a bond NH O NH T3b OH 1063 NO Q1i a bond Me a bond NH O NH T3c OH 1064 N O Q1i a bond Me a bond NH ONH T3d OH 1065 N O Q1i a bond Me a bond NH O NH T3e OH 1066 N O Q1i abond Me a bond NH O NH T3f OH 1067 N O Q1i a bond Me a bond NH O NH T3gOH 1068 N O Q1i a bond Me a bond NH O NH T3h OH 1069 N O Q1i a bond Me abond NH O NH T3i OH 1070 N O Q1i a bond Me a bond NH O NH T3j OH 1071 NO Q1i a bond Me a bond NH O a bond T3a OH 1072 N O Q1i a bond Me a bondNH O a bond T3b OH 1073 N O Q1i a bond Me a bond NH O a bond T3c OH 1074N O Q1i a bond Me a bond NH O a bond T3d OH 1075 N O Q1i a bond Me abond NH O a bond T3e OH 1076 N O Q1i a bond Me a bond NH O a bond T3f OH1077 N O Q1i a bond Me a bond NH O a bond T3g OH 1078 N O Q1i a bond Mea bond NH O a bond T3h OH 1079 N O Q1i a bond Me a bond NH O a bond T3iOH 1080 N O Q1i a bond Me a bond NH O a bond T3j OH 1081 N O Q1i a bondH a bond NH S NH T3a OH 1082 N O Q1i a bond H a bond NH S NH T3b OH 1083N O Q1i a bond H a bond NH S NH T3c OH 1084 N O Q1i a bond H a bond NH SNH T3d OH 1085 N O Q1i a bond H a bond NH S NH T3e OH 1086 N O Q1i abond H a bond NH S NH T3f OH 1087 N O Q1i a bond H a bond NH S NH T3g OH1088 N O Q1i a bond H a bond NH S NH T3h OH 1089 N O Q1i a bond H a bondNH S NH T3i OH 1090 N O Q1i a bond H a bond NH S NH T3j OH 1091 N O Q1ia bond H a bond NH S a bond T3a OH 1092 N O Q1i a bond H a bond NH S abond T3b OH 1093 N O Q1i a bond H a bond NH S a bond T3c OH 1094 N O Q1ia bond H a bond NH S a bond T3d OH 1095 N O Q1i a bond H a bond NH S abond T3e OH 1096 N O Q1i a bond H a bond NH S a bond T3f OH 1097 N O Q1ia bond H a bond NH S a bond T3g OH 1098 N O Q1i a bond H a bond NH S abond T3h OH 1099 N O Q1i a bond H a bond NH S a bond T3i OH 1100 N O Q1ia bond H a bond NH S a bond T3j OH 1101 N O Q1i a bond H a bond NH O NHT3a OH 1102 N O Q1i a bond H a bond NH O NH T3b OH 1103 N O Q1i a bond Ha bond NH O NH T3c OH 1104 N O Q1i a bond H a bond NH O NH T3d OH 1105 NO Q1i a bond H a bond NH O NH T3e OH 1106 N O Q1i a bond H a bond NH ONH T3f OH 1107 N O Q1i a bond H a bond NH O NH T3g OH 1108 N O Q1i abond H a bond NH O NH T3h OH 1109 N O Q1i a bond H a bond NH O NH T3i OH1110 N O Q1i a bond H a bond NH O NH T3j OH 1111 N O Q1i a bond H a bondNH O a bond T3a OH 1112 N O Q1i a bond H a bond NH O a bond T3b OH 1113N O Q1i a bond H a bond NH O a bond T3c OH 1114 N O Q1i a bond H a bondNH O a bond T3d OH 1115 N O Q1i a bond H a bond NH O a bond T3e OH 1116N O Q1i a bond H a bond NH O a bond T3f OH 1117 N O Q1i a bond H a bondNH O a bond T3g OH 1118 N O Q1i a bond H a bond NH O a bond T3h OH 1119N O Q1i a bond H a bond NH O a bond T3i OH 1120 N O Q1i a bond H a bondNH O a bond T3j OH 1121 N O Q1j a bond Me a bond NH S NH T3a OH 1122 N OQ1j a bond Me a bond NH S NH T3b OH 1123 N O Q1j a bond Me a bond NH SNH T3c OH 1124 N O Q1j a bond Me a bond NH S NH T3d OH 1125 N O Q1j abond Me a bond NH S NH T3e OH 1126 N O Q1j a bond Me a bond NH S NH T3fOH 1127 N O Q1j a bond Me a bond NH S NH T3g OH 1128 N O Q1j a bond Me abond NH S NH T3h OH 1129 N O Q1j a bond Me a bond NH S NH T3i OH 1130 NO Q1j a bond Me a bond NH S NH T3j OH 1131 N O Q1j a bond Me a bond NH Sa bond T3a OH 1132 N O Q1j a bond Me a bond NH S a bond T3b OH 1133 N OQ1j a bond Me a bond NH S a bond T3c OH 1134 N O Q1j a bond Me a bond NHS a bond T3d OH 1135 N O Q1j a bond Me a bond NH S a bond T3e OH 1136 NO Q1j a bond Me a bond NH S a bond T3f OH 1137 N O Q1j a bond Me a bondNH S a bond T3g OH 1138 N O Q1j a bond Me a bond NH S a bond T3h OH 1139N O Q1j a bond Me a bond NH S a bond T3i OH 1140 N O Q1j a bond Me abond NH S a bond T3j OH 1141 N O Q1j a bond Me a bond NH O NH T3a OH1142 N O Q1j a bond Me a bond NH O NH T3b OH 1143 N O Q1j a bond Me abond NH O NH T3c OH 1144 N O Q1j a bond Me a bond NH O NH T3d OH 1145 NO Q1j a bond Me a bond NH O NH T3e OH 1146 N O Q1j a bond Me a bond NH ONH T3f OH 1147 N O Q1j a bond Me a bond NH O NH T3g OH 1148 N O Q1j abond Me a bond NH O NH T3h OH 1149 N O Q1j a bond Me a bond NH O NH T3iOH 1150 N O Q1j a bond Me a bond NH O NH T3j OH 1151 N O Q1j a bond Me abond NH O a bond T3a OH 1152 N O Q1j a bond Me a bond NH O a bond T3b OH1153 N O Q1j a bond Me a bond NH O a bond T3c OH 1154 N O Q1j a bond Mea bond NH O a bond T3d OH 1155 N O Q1j a bond Me a bond NH O a bond T3eOH 1156 N O Q1j a bond Me a bond NH O a bond T3f OH 1157 N O Q1j a bondMe a bond NH O a bond T3g OH 1158 N O Q1j a bond Me a bond NH O a bondT3h OH 1159 N O Q1j a bond Me a bond NH O a bond T3i OH 1160 N O Q1j abond Me a bond NH O a bond T3j OH 1161 N O Q1j a bond H a bond NH S NHT3a OH 1162 N O Q1j a bond H a bond NH S NH T3b OH 1163 N O Q1j a bond Ha bond NH S NH T3c OH 1164 N O Q1j a bond H a bond NH S NH T3d OH 1165 NO Q1j a bond H a bond NH S NH T3e OH 1166 N O Q1j a bond H a bond NH SNH T3f OH 1167 N O Q1j a bond H a bond NH S NH T3g OH 1168 N O Q1j abond H a bond NH S NH T3h OH 1169 N O Q1j a bond H a bond NH S NH T3i OH1170 N O Q1j a bond H a bond NH S NH T3j OH 1171 N O Q1j a bond H a bondNH S a bond T3a OH 1172 N O Q1j a bond H a bond NH S a bond T3b OH 1173N O Q1j a bond H a bond NH S a bond T3c OH 1174 N O Q1j a bond H a bondNH S a bond T3d OH 1175 N O Q1j a bond H a bond NH S a bond T3e OH 1176N O Q1j a bond H a bond NH S a bond T3f OH 1177 N O Q1j a bond H a bondNH S a bond T3g OH 1178 N O Q1j a bond H a bond NH S a bond T3h OH 1179N O Q1j a bond H a bond NH S a bond T3i OH 1180 N O Q1j a bond H a bondNH S a bond T3j OH 1181 N O Q1j a bond H a bond NH O NH T3a OH 1182 N OQ1j a bond H a bond NH O NH T3b OH 1183 N O Q1j a bond H a bond NH O NHT3c OH 1184 N O Q1j a bond H a bond NH O NH T3d OH 1185 N O Q1j a bond Ha bond NH O NH T3e OH 1186 N O Q1j a bond H a bond NH O NH T3f OH 1187 NO Q1j a bond H a bond NH O NH T3g OH 1188 N O Q1j a bond H a bond NH ONH T3h OH 1189 N O Q1j a bond H a bond NH O NH T3i OH 1190 N O Q1j abond H a bond NH O NH T3j OH 1191 N O Q1j a bond H a bond NH O a bondT3a OH 1192 N O Q1j a bond H a bond NH O a bond T3b OH 1193 N O Q1j abond H a bond NH O a bond T3c OH 1194 N O Q1j a bond H a bond NH O abond T3d OH 1195 N O Q1j a bond H a bond NH O a bond T3e OH 1196 N O Q1ja bond H a bond NH O a bond T3f OH 1197 N O Q1j a bond H a bond NH O abond T3g OH 1198 N O Q1j a bond H a bond NH O a bond T3h OH 1199 N O Q1ja bond H a bond NH O a bond T3i OH 1200 N O Q1j a bond H a bond NH O abond T3j OH 1201 CH NMe Q1a a bond Me a bond NH S NH T3a OH 1202 CH NMeQ1a a bond Me a bond NH S NH T3b OH 1203 CH NMe Q1a a bond Me a bond NHS NH T3c OH 1204 CH NMe Q1a a bond Me a bond NH S NH T3d OH 1205 CH NMeQ1a a bond Me a bond NH S NH T3e OH 1206 CH NMe Q1a a bond Me a bond NHS NH T3f OH 1207 CH NMe Q1a a bond Me a bond NH S NH T3g OH 1208 CH NMeQ1a a bond Me a bond NH S NH T3h OH 1209 CH NMe Q1a a bond Me a bond NHS NH T3i OH 1210 CH NMe Q1a a bond Me a bond NH S NH T3j OH 1211 CH NMeQ1a a bond Me a bond NH S a bond T3a OH 1212 CH NMe Q1a a bond Me a bondNH S a bond T3b OH 1213 CH NMe Q1a a bond Me a bond NH S a bond T3c OH1214 CH NMe Q1a a bond Me a bond NH S a bond T3d OH 1215 CH NMe Q1a abond Me a bond NH S a bond T3e OH 1216 CH NMe Q1a a bond Me a bond NH Sa bond T3f OH 1217 CH NMe Q1a a bond Me a bond NH S a bond T3g OH 1218CH NMe Q1a a bond Me a bond NH S a bond T3h OH 1219 CH NMe Q1a a bond Mea bond NH S a bond T3i OH 1220 CH NMe Q1a a bond Me a bond NH S a bondT3j OH 1221 CH NMe Q1a a bond Me a bond NH O NH T3a OH 1222 CH NMe Q1a abond Me a bond NH O NH T3b OH 1223 CH NMe Q1a a bond Me a bond NH O NHT3c OH 1224 CH NMe Q1a a bond Me a bond NH O NH T3d OH 1225 CH NMe Q1a abond Me a bond NH O NH T3e OH 1226 CH NMe Q1a a bond Me a bond NH O NHT3f OH 1227 CH NMe Q1a a bond Me a bond NH O NH T3g OH 1228 CH NMe Q1a abond Me a bond NH O NH T3h OH 1229 CH NMe Q1a a bond Me a bond NH O NHT3i OH 1230 CH NMe Q1a a bond Me a bond NH O NH T3j OH 1231 CH NMe Q1a abond Me a bond NH O a bond T3a OH 1232 CH NMe Q1a a bond Me a bond NH Oa bond T3b OH 1233 CH NMe Q1a a bond Me a bond NH O a bond T3c OH 1234CH NMe Q1a a bond Me a bond NH O a bond T3d OH 1235 CH NMe Q1a a bond Mea bond NH O a bond T3e OH 1236 CH NMe Q1a a bond Me a bond NH O a bondT3f OH 1237 CH NMe Q1a a bond Me a bond NH O a bond T3g OH 1238 CH NMeQ1a a bond Me a bond NH O a bond T3h OH 1239 CH NMe Q1a a bond Me a bondNH O a bond T3i OH 1240 CH NMe Q1a a bond Me a bond NH O a bond T3j OH1241 CH NMe Q1a a bond H a bond NH S NH T3a OH 1242 CH NMe Q1a a bond Ha bond NH S NH T3b OH 1243 CH NMe Q1a a bond H a bond NH S NH T3c OH1244 CH NMe Q1a a bond H a bond NH S NH T3d OH 1245 CH NMe Q1a a bond Ha bond NH S NH T3e OH 1246 CH NMe Q1a a bond H a bond NH S NH T3f OH1247 CH NMe Q1a a bond H a bond NH S NH T3g OH 1248 CH NMe Q1a a bond Ha bond NH S NH T3h OH 1249 CH NMe Q1a a bond H a bond NH S NH T3i OH1250 CH NMe Q1a a bond H a bond NH S NH T3j OH 1251 CH NMe Q1a a bond Ha bond NH S a bond T3a OH 1252 CH NMe Q1a a bond H a bond NH S a bondT3b OH 1253 CH NMe Q1a a bond H a bond NH S a bond T3c OH 1254 CH NMeQ1a a bond H a bond NH S a bond T3d OH 1255 CH NMe Q1a a bond H a bondNH S a bond T3e OH 1256 CH NMe Q1a a bond H a bond NH S a bond T3f OH1257 CH NMe Q1a a bond H a bond NH S a bond T3g OH 1258 CH NMe Q1a abond H a bond NH S a bond T3h OH 1259 CH NMe Q1a a bond H a bond NH S abond T3i OH 1260 CH NMe Q1a a bond H a bond NH S a bond T3j OH 1261 CHNMe Q1a a bond H a bond NH O NH T3a OH 1262 CH NMe Q1a a bond H a bondNH O NH T3b OH 1263 CH NMe Q1a a bond H a bond NH O NH T3c OH 1264 CHNMe Q1a a bond H a bond NH O NH T3d OH 1265 CH NMe Q1a a bond H a bondNH O NH T3e OH 1266 CH NMe Q1a a bond H a bond NH O NH T3f OH 1267 CHNMe Q1a a bond H a bond NH O NH T3g OH 1268 CH NMe Q1a a bond H a bondNH O NH T3h OH 1269 CH NMe Q1a a bond H a bond NH O NH T3i OH 1270 CHNMe Q1a a bond H a bond NH O NH T3j OH 1271 CH NMe Q1a a bond H a bondNH O a bond T3a OH 1272 CH NMe Q1a a bond H a bond NH O a bond T3b OH1273 CH NMe Q1a a bond H a bond NH O a bond T3c OH 1274 CH NMe Q1a abond H a bond NH O a bond T3d OH 1275 CH NMe Q1a a bond H a bond NH O abond T3e OH 1276 CH NMe Q1a a bond H a bond NH O a bond T3f OH 1277 CHNMe Q1a a bond H a bond NH O a bond T3g OH 1278 CH NMe Q1a a bond H abond NH O a bond T3h OH 1279 CH NMe Q1a a bond H a bond NH O a bond T3iOH 1280 CH NMe Q1a a bond H a bond NH O a bond T3j OH 1281 CH NMe Q1b abond Me a bond NH S NH T3a OH 1282 CH NMe Q1b a bond Me a bond NH S NHT3b OH 1283 CH NMe Q1b a bond Me a bond NH S NH T3c OH 1284 CH NMe Q1b abond Me a bond NH S NH T3d OH 1285 CH NMe Q1b a bond Me a bond NH S NHT3e OH 1286 CH NMe Q1b a bond Me a bond NH S NH T3f OH 1287 CH NMe Q1b abond Me a bond NH S NH T3g OH 1288 CH NMe Q1b a bond Me a bond NH S NHT3h OH 1289 CH NMe Q1b a bond Me a bond NH S NH T3i OH 1290 CH NMe Q1b abond Me a bond NH S NH T3j OH 1291 CH NMe Q1b a bond Me a bond NH S abond T3a OH 1292 CH NMe Q1b a bond Me a bond NH S a bond T3b OH 1293 CHNMe Q1b a bond Me a bond NH S a bond T3c OH 1294 CH NMe Q1b a bond Me abond NH S a bond T3d OH 1295 CH NMe Q1b a bond Me a bond NH S a bond T3eOH 1296 CH NMe Q1b a bond Me a bond NH S a bond T3f OH 1297 CH NMe Q1b abond Me a bond NH S a bond T3g OH 1298 CH NMe Q1b a bond Me a bond NH Sa bond T3h OH 1299 CH NMe Q1b a bond Me a bond NH S a bond T3i OH 1300CH NMe Q1b a bond Me a bond NH S a bond T3j OH 1301 CH NMe Q1b a bond Mea bond NH O NH T3a OH 1302 CH NMe Q1b a bond Me a bond NH O NH T3b OH1303 CH NMe Q1b a bond Me a bond NH O NH T3c OH 1304 CH NMe Q1b a bondMe a bond NH O NH T3d OH 1305 CH NMe Q1b a bond Me a bond NH O NH T3e OH1306 CH NMe Q1b a bond Me a bond NH O NH T3f OH 1307 CH NMe Q1b a bondMe a bond NH O NH T3g OH 1308 CH NMe Q1b a bond Me a bond NH O NH T3h OH1309 CH NMe Q1b a bond Me a bond NH O NH T3i OH 1310 CH NMe Q1b a bondMe a bond NH O NH T3j OH 1311 CH NMe Q1b a bond Me a bond NH O a bondT3a OH 1312 CH NMe Q1b a bond Me a bond NH O a bond T3b OH 1313 CH NMeQ1b a bond Me a bond NH O a bond T3c OH 1314 CH NMe Q1b a bond Me a bondNH O a bond T3d OH 1315 CH NMe Q1b a bond Me a bond NH O a bond T3e OH1316 CH NMe Q1b a bond Me a bond NH O a bond T3f OH 1317 CH NMe Q1b abond Me a bond NH O a bond T3g OH 1318 CH NMe Q1b a bond Me a bond NH Oa bond T3h OH 1319 CH NMe Q1b a bond Me a bond NH O a bond T3i OH 1320CH NMe Q1b a bond Me a bond NH O a bond T3j OH 1321 CH NMe Q1b a bond Ha bond NH S NH T3a OH 1322 CH NMe Q1b a bond H a bond NH S NH T3b OH1323 CH NMe Q1b a bond H a bond NH S NH T3c OH 1324 CH NMe Q1b a bond Ha bond NH S NH T3d OH 1325 CH NMe Q1b a bond H a bond NH S NH T3e OH1326 CH NMe Q1b a bond H a bond NH S NH T3f OH 1327 CH NMe Q1b a bond Ha bond NH S NH T3g OH 1328 CH NMe Q1b a bond H a bond NH S NH T3h OH1329 CH NMe Q1b a bond H a bond NH S NH T3i OH 1330 CH NMe Q1b a bond Ha bond NH S NH T3j OH 1331 CH NMe Q1b a bond H a bond NH S a bond T3a OH1332 CH NMe Q1b a bond H a bond NH S a bond T3b OH 1333 CH NMe Q1b abond H a bond NH S a bond T3c OH 1334 CH NMe Q1b a bond H a bond NH S abond T3d OH 1335 CH NMe Q1b a bond H a bond NH S a bond T3e OH 1336 CHNMe Q1b a bond H a bond NH S a bond T3f OH 1337 CH NMe Q1b a bond H abond NH S a bond T3g OH 1338 CH NMe Q1b a bond H a bond NH S a bond T3hOH 1339 CH NMe Q1b a bond H a bond NH S a bond T3i OH 1340 CH NMe Q1b abond H a bond NH S a bond T3j OH 1341 CH NMe Q1b a bond H a bond NH O NHT3a OH 1342 CH NMe Q1b a bond H a bond NH O NH T3b OH 1343 CH NMe Q1b abond H a bond NH O NH T3c OH 1344 CH NMe Q1b a bond H a bond NH O NH T3dOH 1345 CH NMe Q1b a bond H a bond NH O NH T3e OH 1346 CH NMe Q1b a bondH a bond NH O NH T3f OH 1347 CH NMe Q1b a bond H a bond NH O NH T3g OH1348 CH NMe Q1b a bond H a bond NH O NH T3h OH 1349 CH NMe Q1b a bond Ha bond NH O NH T3i OH 1350 CH NMe Q1b a bond H a bond NH O NH T3j OH1351 CH NMe Q1b a bond H a bond NH O a bond T3a OH 1352 CH NMe Q1b abond H a bond NH O a bond T3b OH 1353 CH NMe Q1b a bond H a bond NH O abond T3c OH 1354 CH NMe Q1b a bond H a bond NH O a bond T3d OH 1355 CHNMe Q1b a bond H a bond NH O a bond T3e OH 1356 CH NMe Q1b a bond H abond NH O a bond T3f OH 1357 CH NMe Q1b a bond H a bond NH O a bond T3gOH 1358 CH NMe Q1b a bond H a bond NH O a bond T3h OH 1359 CH NMe Q1b abond H a bond NH O a bond T3i OH 1360 CH NMe Q1b a bond H a bond NH O abond T3j OH 1361 CH NMe Q1c a bond Me a bond NH S NH T3a OH 1362 CH NMeQ1c a bond Me a bond NH S NH T3b OH 1363 CH NMe Q1c a bond Me a bond NHS NH T3c OH 1364 CH NMe Q1c a bond Me a bond NH S NH T3d OH 1365 CH NMeQ1c a bond Me a bond NH S NH T3e OH 1366 CH NMe Q1c a bond Me a bond NHS NH T3f OH 1367 CH NMe Q1c a bond Me a bond NH S NH T3g OH 1368 CH NMeQ1c a bond Me a bond NH S NH T3h OH 1369 CH NMe Q1c a bond Me a bond NHS NH T3i OH 1370 CH NMe Q1c a bond Me a bond NH S NH T3j OH 1371 CH NMeQ1c a bond Me a bond NH S a bond T3a OH 1372 CH NMe Q1c a bond Me a bondNH S a bond T3b OH 1373 CH NMe Q1c a bond Me a bond NH S a bond T3c OH1374 CH NMe Q1c a bond Me a bond NH S a bond T3d OH 1375 CH NMe Q1c abond Me a bond NH S a bond T3e OH 1376 CH NMe Q1c a bond Me a bond NH Sa bond T3f OH 1377 CH NMe Q1c a bond Me a bond NH S a bond T3g OH 1378CH NMe Q1c a bond Me a bond NH S a bond T3h OH 1379 CH NMe Q1c a bond Mea bond NH S a bond T3i OH 1380 CH NMe Q1c a bond Me a bond NH S a bondT3j OH 1381 CH NMe Q1c a bond Me a bond NH O NH T3a OH 1382 CH NMe Q1c abond Me a bond NH O NH T3b OH 1383 CH NMe Q1c a bond Me a bond NH O NHT3c OH 1384 CH NMe Q1c a bond Me a bond NH O NH T3d OH 1385 CH NMe Q1c abond Me a bond NH O NH T3e OH 1386 CH NMe Q1c a bond Me a bond NH O NHT3f OH 1387 CH NMe Q1c a bond Me a bond NH O NH T3g OH 1388 CH NMe Q1c abond Me a bond NH O NH T3h OH 1389 CH NMe Q1c a bond Me a bond NH O NHT3i OH 1390 CH NMe Q1c a bond Me a bond NH O NH T3j OH 1391 CH NMe Q1c abond Me a bond NH O a bond T3a OH 1392 CH NMe Q1c a bond Me a bond NH Oa bond T3b OH 1393 CH NMe Q1c a bond Me a bond NH O a bond T3c OH 1394CH NMe Q1c a bond Me a bond NH O a bond T3d OH 1395 CH NMe Q1c a bond Mea bond NH O a bond T3e OH 1396 CH NMe Q1c a bond Me a bond NH O a bondT3f OH 1397 CH NMe Q1c a bond Me a bond NH O a bond T3g OH 1398 CH NMeQ1c a bond Me a bond NH O a bond T3h OH 1399 CH NMe Q1c a bond Me a bondNH O a bond T3i OH 1400 CH NMe Q1c a bond Me a bond NH O a bond T3j OH1401 CH NMe Q1c a bond H a bond NH S NH T3a OH 1402 CH NMe Q1c a bond Ha bond NH S NH T3b OH 1403 CH NMe Q1c a bond H a bond NH S NH T3c OH1404 CH NMe Q1c a bond H a bond NH S NH T3d OH 1405 CH NMe Q1c a bond Ha bond NH S NH T3e OH 1406 CH NMe Q1c a bond H a bond NH S NH T3f OH1407 CH NMe Q1c a bond H a bond NH S NH T3g OH 1408 CH NMe Q1c a bond Ha bond NH S NH T3h OH 1409 CH NMe Q1c a bond H a bond NH S NH T3i OH1410 CH NMe Q1c a bond H a bond NH S NH T3j OH 1411 CH NMe Q1c a bond Ha bond NH S a bond T3a OH 1412 CH NMe Q1c a bond H a bond NH S a bondT3b OH 1413 CH NMe Q1c a bond H a bond NH S a bond T3c OH 1414 CH NMeQ1c a bond H a bond NH S a bond T3d OH 1415 CH NMe Q1c a bond H a bondNH S a bond T3e OH 1416 CH NMe Q1c a bond H a bond NH S a bond T3f OH1417 CH NMe Q1c a bond H a bond NH S a bond T3g OH 1418 CH NMe Q1c abond H a bond NH S a bond T3h OH 1419 CH NMe Q1c a bond H a bond NH S abond T3i OH 1420 CH NMe Q1c a bond H a bond NH S a bond T3j OH 1421 CHNMe Q1c a bond H a bond NH O NH T3a OH 1422 CH NMe Q1c a bond H a bondNH O NH T3b OH 1423 CH NMe Q1c a bond H a bond NH O NH T3c OH 1424 CHNMe Q1c a bond H a bond NH O NH T3d OH 1425 CH NMe Q1c a bond H a bondNH O NH T3e OH 1426 CH NMe Q1c a bond H a bond NH O NH T3f OH 1427 CHNMe Q1c a bond H a bond NH O NH T3g OH 1428 CH NMe Q1c a bond H a bondNH O NH T3h OH 1429 CH NMe Q1c a bond H a bond NH O NH T3i OH 1430 CHNMe Q1c a bond H a bond NH O NH T3j OH 1431 CH NMe Q1c a bond H a bondNH O a bond T3a OH 1432 CH NMe Q1c a bond H a bond NH O a bond T3b OH1433 CH NMe Q1c a bond H a bond NH O a bond T3c OH 1434 CH NMe Q1c abond H a bond NH O a bond T3d OH 1435 CH NMe Q1c a bond H a bond NH O abond T3e OH 1436 CH NMe Q1c a bond H a bond NH O a bond T3f OH 1437 CHNMe Q1c a bond H a bond NH O a bond T3g OH 1438 CH NMe Q1c a bond H abond NH O a bond T3h OH 1439 CH NMe Q1c a bond H a bond NH O a bond T3iOH 1440 CH NMe Q1c a bond H a bond NH O a bond T3j OH 1441 CH NMe Q1i abond Me a bond NH S NH T3a OH 1442 CH NMe Q1i a bond Me a bond NH S NHT3b OH 1443 CH NMe Q1i a bond Me a bond NH S NH T3c OH 1444 CH NMe Q1i abond Me a bond NH S NH T3d OH 1445 CH NMe Q1i a bond Me a bond NH S NHT3e OH 1446 CH NMe Q1i a bond Me a bond NH S NH T3f OH 1447 CH NMe Q1i abond Me a bond NH S NH T3g OH 1448 CH NMe Q1i a bond Me a bond NH S NHT3h OH 1449 CH NMe Q1i a bond Me a bond NH S NH T3i OH 1450 CH NMe Q1i abond Me a bond NH S NH T3j OH 1451 CH NMe Q1i a bond Me a bond NH S abond T3a OH 1452 CH NMe Q1i a bond Me a bond NH S a bond T3b OH 1453 CHNMe Q1i a bond Me a bond NH S a bond T3c OH 1454 CH NMe Q1i a bond Me abond NH S a bond T3d OH 1455 CH NMe Q1i a bond Me a bond NH S a bond T3eOH 1456 CH NMe Q1i a bond Me a bond NH S a bond T3f OH 1457 CH NMe Q1i abond Me a bond NH S a bond T3g OH 1458 CH NMe Q1i a bond Me a bond NH Sa bond T3h OH 1459 CH NMe Q1i a bond Me a bond NH S a bond T3i OH 1460CH NMe Q1i a bond Me a bond NH S a bond T3j OH 1461 CH NMe Q1i a bond Mea bond NH O NH T3a OH 1462 CH NMe Q1i a bond Me a bond NH O NH T3b OH1463 CH NMe Q1i a bond Me a bond NH O NH T3c OH 1464 CH NMe Q1i a bondMe a bond NH O NH T3d OH 1465 CH NMe Q1i a bond Me a bond NH O NH T3e OH1466 CH NMe Q1i a bond Me a bond NH O NH T3f OH 1467 CH NMe Q1i a bondMe a bond NH O NH T3g OH 1468 CH NMe Q1i a bond Me a bond NH O NH T3h OH1469 CH NMe Q1i a bond Me a bond NH O NH T3i OH 1470 CH NMe Q1i a bondMe a bond NH O NH T3j OH 1471 CH NMe Q1i a bond Me a bond NH O a bondT3a OH 1472 CH NMe Q1i a bond Me a bond NH O a bond T3b OH 1473 CH NMeQ1i a bond Me a bond NH O a bond T3c OH 1474 CH NMe Q1i a bond Me a bondNH O a bond T3d OH 1475 CH NMe Q1i a bond Me a bond NH O a bond T3e OH1476 CH NMe Q1i a bond Me a bond NH O a bond T3f OH 1477 CH NMe Q1i abond Me a bond NH O a bond T3g OH 1478 CH NMe Q1i a bond Me a bond NH Oa bond T3h OH 1479 CH NMe Q1i a bond Me a bond NH O a bond T3i OH 1480CH NMe Q1i a bond Me a bond NH O a bond T3j OH 1481 CH NMe Q1i a bond Ha bond NH S NH T3a OH 1482 CH NMe Q1i a bond H a bond NH S NH T3b OH1483 CH NMe Q1i a bond H a bond NH S NH T3c OH 1484 CH NMe Q1i a bond Ha bond NH S NH T3d OH 1485 CH NMe Q1i a bond H a bond NH S NH T3e OH1486 CH NMe Q1i a bond H a bond NH S NH T3f OH 1487 CH NMe Q1i a bond Ha bond NH S NH T3g OH 1488 CH NMe Q1i a bond H a bond NH S NH T3h OH1489 CH NMe Q1i a bond H a bond NH S NH T3i OH 1490 CH NMe Q1i a bond Ha bond NH S NH T3j OH 1491 CH NMe Q1i a bond H a bond NH S a bond T3a OH1492 CH NMe Q1i a bond H a bond NH S a bond T3b OH 1493 CH NMe Q1i abond H a bond NH S a bond T3c OH 1494 CH NMe Q1i a bond H a bond NH S abond T3d OH 1495 CH NMe Q1i a bond H a bond NH S a bond T3e OH 1496 CHNMe Q1i a bond H a bond NH S a bond T3f OH 1497 CH NMe Q1i a bond H abond NH S a bond T3g OH 1498 CH NMe Q1i a bond H a bond NH S a bond T3hOH 1499 CH NMe Q1i a bond H a bond NH S a bond T3i OH 1500 CH NMe Q1i abond H a bond NH S a bond T3j OH 1501 CH NMe Q1i a bond H a bond NH O NHT3a OH 1502 CH NMe Q1i a bond H a bond NH O NH T3b OH 1503 CH NMe Q1i abond H a bond NH O NH T3c OH 1504 CH NMe Q1i a bond H a bond NH O NH T3dOH 1505 CH NMe Q1i a bond H a bond NH O NH T3e OH 1506 CH NMe Q1i a bondH a bond NH O NH T3f OH 1507 CH NMe Q1i a bond H a bond NH O NH T3g OH1508 CH NMe Q1i a bond H a bond NH O NH T3h OH 1509 CH NMe Q1i a bond Ha bond NH O NH T3i OH 1510 CH NMe Q1i a bond H a bond NH O NH T3j OH1511 CH NMe Q1i a bond H a bond NH O a bond T3a OH 1512 CH NMe Q1i abond H a bond NH O a bond T3b OH 1513 CH NMe Q1i a bond H a bond NH O abond T3c OH 1514 CH NMe Q1i a bond H a bond NH O a bond T3d OH 1515 CHNMe Q1i a bond H a bond NH O a bond T3e OH 1516 CH NMe Q1i a bond H abond NH O a bond T3f OH 1517 CH NMe Q1i a bond H a bond NH O a bond T3gOH 1518 CH NMe Q1i a bond H a bond NH O a bond T3h OH 1519 CH NMe Q1i abond H a bond NH O a bond T3i OH 1520 CH NMe Q1i a bond H a bond NH O abond T3j OH 1521 CH NMe Q1j a bond Me a bond NH S NH T3a OH 1522 CH NMeQ1j a bond Me a bond NH S NH T3b OH 1523 CH NMe Q1j a bond Me a bond NHS NH T3c OH 1524 CH NMe Q1j a bond Me a bond NH S NH T3d OH 1525 CH NMeQ1j a bond Me a bond NH S NH T3e OH 1526 CH NMe Q1j a bond Me a bond NHS NH T3f OH 1527 CH NMe Q1j a bond Me a bond NH S NH T3g OH 1528 CH NMeQ1j a bond Me a bond NH S NH T3h OH 1529 CH NMe Q1j a bond Me a bond NHS NH T3i OH 1530 CH NMe Q1j a bond Me a bond NH S NH T3j OH 1531 CH NMeQ1j a bond Me a bond NH S a bond T3a OH 1532 CH NMe Q1j a bond Me a bondNH S a bond T3b OH 1533 CH NMe Q1j a bond Me a bond NH S a bond T3c OH1534 CH NMe Q1j a bond Me a bond NH S a bond T3d OH 1535 CH NMe Q1j abond Me a bond NH S a bond T3e OH 1536 CH NMe Q1j a bond Me a bond NH Sa bond T3f OH 1537 CH NMe Q1j a bond Me a bond NH S a bond T3g OH 1538CH NMe Q1j a bond Me a bond NH S a bond T3h OH 1539 CH NMe Q1j a bond Mea bond NH S a bond T3i OH 1540 CH NMe Q1j a bond Me a bond NH S a bondT3j OH 1541 CH NMe Q1j a bond Me a bond NH O NH T3a OH 1542 CH NMe Q1j abond Me a bond NH O NH T3b OH 1543 CH NMe Q1j a bond Me a bond NH O NHT3c OH 1544 CH NMe Q1j a bond Me a bond NH O NH T3d OH 1545 CH NMe Q1j abond Me a bond NH O NH T3e OH 1546 CH NMe Q1j a bond Me a bond NH O NHT3f OH 1547 CH NMe Q1j a bond Me a bond NH O NH T3g OH 1548 CH NMe Q1j abond Me a bond NH O NH T3h OH 1549 CH NMe Q1j a bond Me a bond NH O NHT3i OH 1550 CH NMe Q1j a bond Me a bond NH O NH T3j OH 1551 CH NMe Q1j abond Me a bond NH O a bond T3a OH 1552 CH NMe Q1j a bond Me a bond NH Oa bond T3b OH 1553 CH NMe Q1j a bond Me a bond NH O a bond T3c OH 1554CH NMe Q1j a bond Me a bond NH O a bond T3d OH 1555 CH NMe Q1j a bond Mea bond NH O a bond T3e OH 1556 CH NMe Q1j a bond Me a bond NH O a bondT3f OH 1557 CH NMe Q1j a bond Me a bond NH O a bond T3g OH 1558 CH NMeQ1j a bond Me a bond NH O a bond T3h OH 1559 CH NMe Q1j a bond Me a bondNH O a bond T3i OH 1560 CH NMe Q1j a bond Me a bond NH O a bond T3j OH1561 CH NMe Q1j a bond H a bond NH S NH T3a OH 1562 CH NMe Q1j a bond Ha bond NH S NH T3b OH 1563 CH NMe Q1j a bond H a bond NH S NH T3c OH1564 CH NMe Q1j a bond H a bond NH S NH T3d OH 1565 CH NMe Q1j a bond Ha bond NH S NH T3e OH 1566 CH NMe Q1j a bond H a bond NH S NH T3f OH1567 CH NMe Q1j a bond H a bond NH S NH T3g OH 1568 CH NMe Q1j a bond Ha bond NH S NH T3h OH 1569 CH NMe Q1j a bond H a bond NH S NH T3i OH1570 CH NMe Q1j a bond H a bond NH S NH T3j OH 1571 CH NMe Q1j a bond Ha bond NH S a bond T3a OH 1572 CH NMe Q1j a bond H a bond NH S a bondT3b OH 1573 CH NMe Q1j a bond H a bond NH S a bond T3c OH 1574 CH NMeQ1j a bond H a bond NH S a bond T3d OH 1575 CH NMe Q1j a bond H a bondNH S a bond T3e OH 1576 CH NMe Q1j a bond H a bond NH S a bond T3f OH1577 CH NMe Q1j a bond H a bond NH S a bond T3g OH 1578 CH NMe Q1j abond H a bond NH S a bond T3h OH 1579 CH NMe Q1j a bond H a bond NH S abond T3i OH 1580 CH NMe Q1j a bond H a bond NH S a bond T3j OH 1581 CHNMe Q1j a bond H a bond NH O NH T3a OH 1582 CH NMe Q1j a bond H a bondNH O NH T3b OH 1583 CH NMe Q1j a bond H a bond NH O NH T3c OH 1584 CHNMe Q1j a bond H a bond NH O NH T3d OH 1585 CH NMe Q1j a bond H a bondNH O NH T3e OH 1586 CH NMe Q1j a bond H a bond NH O NH T3f OH 1587 CHNMe Q1j a bond H a bond NH O NH T3g OH 1588 CH NMe Q1j a bond H a bondNH O NH T3h OH 1589 CH NMe Q1j a bond H a bond NH O NH T3i OH 1590 CHNMe Q1j a bond H a bond NH O NH T3j OH 1591 CH NMe Q1j a bond H a bondNH O a bond T3a OH 1592 CH NMe Q1j a bond H a bond NH O a bond T3b OH1593 CH NMe Q1j a bond H a bond NH O a bond T3c OH 1594 CH NMe Q1j abond H a bond NH O a bond T3d OH 1595 CH NMe Q1j a bond H a bond NH O abond T3e OH 1596 CH NMe Q1j a bond H a bond NH O a bond T3f OH 1597 CHNMe Q1j a bond H a bond NH O a bond T3g OH 1598 CH NMe Q1j a bond H abond NH O a bond T3h OH 1599 CH NMe Q1j a bond H a bond NH O a bond T3iOH 1600 CH NMe Q1j a bond H a bond NH O a bond T3j OH 1601 CH S Q1a abond Me a bond NH S NH T3a OH 1602 CH S Q1a a bond Me a bond NH S NH T3bOH 1603 CH S Q1a a bond Me a bond NH S NH T3c OH 1604 CH S Q1a a bond Mea bond NH S NH T3d OH 1605 CH S Q1a a bond Me a bond NH S NH T3e OH 1606CH S Q1a a bond Me a bond NH S NH T3f OH 1607 CH S Q1a a bond Me a bondNH S NH T3g OH 1608 CH S Q1a a bond Me a bond NH S NH T3h OH 1609 CH SQ1a a bond Me a bond NH S NH T3i OH 1610 CH S Q1a a bond Me a bond NH SNH T3j OH 1611 CH S Q1a a bond Me a bond NH S a bond T3a OH 1612 CH SQ1a a bond Me a bond NH S a bond T3b OH 1613 CH S Q1a a bond Me a bondNH S a bond T3c OH 1614 CH S Q1a a bond Me a bond NH S a bond T3d OH1615 CH S Q1a a bond Me a bond NH S a bond T3e OH 1616 CH S Q1a a bondMe a bond NH S a bond T3f OH 1617 CH S Q1a a bond Me a bond NH S a bondT3g OH 1618 CH S Q1a a bond Me a bond NH S a bond T3h OH 1619 CH S Q1a abond Me a bond NH S a bond T3i OH 1620 CH S Q1a a bond Me a bond NH S abond T3j OH 1621 CH S Q1a a bond Me a bond NH O NH T3a OH 1622 CH S Q1aa bond Me a bond NH O NH T3b OH 1623 CH S Q1a a bond Me a bond NH O NHT3c OH 1624 CH S Q1a a bond Me a bond NH O NH T3d OH 1625 CH S Q1a abond Me a bond NH O NH T3e OH 1626 CH S Q1a a bond Me a bond NH O NH T3fOH 1627 CH S Q1a a bond Me a bond NH O NH T3g OH 1628 CH S Q1a a bond Mea bond NH O NH T3h OH 1629 CH S Q1a a bond Me a bond NH O NH T3i OH 1630CH S Q1a a bond Me a bond NH O NH T3j OH 1631 CH S Q1a a bond Me a bondNH O a bond T3a OH 1632 CH S Q1a a bond Me a bond NH O a bond T3b OH1633 CH S Q1a a bond Me a bond NH O a bond T3c OH 1634 CH S Q1a a bondMe a bond NH O a bond T3d OH 1635 CH S Q1a a bond Me a bond NH O a bondT3e OH 1636 CH S Q1a a bond Me a bond NH O a bond T3f OH 1637 CH S Q1a abond Me a bond NH O a bond T3g OH 1638 CH S Q1a a bond Me a bond NH O abond T3h OH 1639 CH S Q1a a bond Me a bond NH O a bond T3i OH 1640 CH SQ1a a bond Me a bond NH O a bond T3j OH 1641 CH S Q1a a bond H a bond NHS NH T3a OH 1642 CH S Q1a a bond H a bond NH S NH T3b OH 1643 CH S Q1a abond H a bond NH S NH T3c OH 1644 CH S Q1a a bond H a bond NH S NH T3dOH 1645 CH S Q1a a bond H a bond NH S NH T3e OH 1646 CH S Q1a a bond H abond NH S NH T3f OH 1647 CH S Q1a a bond H a bond NH S NH T3g OH 1648 CHS Q1a a bond H a bond NH S NH T3h OH 1649 CH S Q1a a bond H a bond NH SNH T3i OH 1650 CH S Q1a a bond H a bond NH S NH T3j OH 1651 CH S Q1a abond H a bond NH S a bond T3a OH 1652 CH S Q1a a bond H a bond NH S abond T3b OH 1653 CH S Q1a a bond H a bond NH S a bond T3c OH 1654 CH SQ1a a bond H a bond NH S a bond T3d OH 1655 CH S Q1a a bond H a bond NHS a bond T3e OH 1656 CH S Q1a a bond H a bond NH S a bond T3f OH 1657 CHS Q1a a bond H a bond NH S a bond T3g OH 1658 CH S Q1a a bond H a bondNH S a bond T3h OH 1659 CH S Q1a a bond H a bond NH S a bond T3i OH 1660CH S Q1a a bond H a bond NH S a bond T3j OH 1661 CH S Q1a a bond H abond NH O NH T3a OH 1662 CH S Q1a a bond H a bond NH O NH T3b OH 1663 CHS Q1a a bond H a bond NH O NH T3c OH 1664 CH S Q1a a bond H a bond NH ONH T3d OH 1665 CH S Q1a a bond H a bond NH O NH T3e OH 1666 CH S Q1a abond H a bond NH O NH T3f OH 1667 CH S Q1a a bond H a bond NH O NH T3gOH 1668 CH S Q1a a bond H a bond NH O NH T3h OH 1669 CH S Q1a a bond H abond NH O NH T3i OH 1670 CH S Q1a a bond H a bond NH O NH T3j OH 1671 CHS Q1a a bond H a bond NH O a bond T3a OH 1672 CH S Q1a a bond H a bondNH O a bond T3b OH 1673 CH S Q1a a bond H a bond NH O a bond T3c OH 1674CH S Q1a a bond H a bond NH O a bond T3d OH 1675 CH S Q1a a bond H abond NH O a bond T3e OH 1676 CH S Q1a a bond H a bond NH O a bond T3f OH1677 CH S Q1a a bond H a bond NH O a bond T3g OH 1678 CH S Q1a a bond Ha bond NH O a bond T3h OH 1679 CH S Q1a a bond H a bond NH O a bond T3iOH 1680 CH S Q1a a bond H a bond NH O a bond T3j OH 1681 CH S Q1b a bondMe a bond NH S NH T3a OH 1682 CH S Q1b a bond Me a bond NH S NH T3b OH1683 CH S Q1b a bond Me a bond NH S NH T3c OH 1684 CH S Q1b a bond Me abond NH S NH T3d OH 1685 CH S Q1b a bond Me a bond NH S NH T3e OH 1686CH S Q1b a bond Me a bond NH S NH T3f OH 1687 CH S Q1b a bond Me a bondNH S NH T3g OH 1688 CH S Q1b a bond Me a bond NH S NH T3h OH 1689 CH SQ1b a bond Me a bond NH S NH T3i OH 1690 CH S Q1b a bond Me a bond NH SNH T3j OH 1691 CH S Q1b a bond Me a bond NH S a bond T3a OH 1692 CH SQ1b a bond Me a bond NH S a bond T3b OH 1693 CH S Q1b a bond Me a bondNH S a bond T3c OH 1694 CH S Q1b a bond Me a bond NH S a bond T3d OH1695 CH S Q1b a bond Me a bond NH S a bond T3e OH 1696 CH S Q1b a bondMe a bond NH S a bond T3f OH 1697 CH S Q1b a bond Me a bond NH S a bondT3g OH 1698 CH S Q1b a bond Me a bond NH S a bond T3h OH 1699 CH S Q1b abond Me a bond NH S a bond T3i OH 1700 CH S Q1b a bond Me a bond NH S abond T3j OH 1701 CH S Q1b a bond Me a bond NH O NH T3a OH 1702 CH S Q1ba bond Me a bond NH O NH T3b OH 1703 CH S Q1b a bond Me a bond NH O NHT3c OH 1704 CH S Q1b a bond Me a bond NH O NH T3d OH 1705 CH S Q1b abond Me a bond NH O NH T3e OH 1706 CH S Q1b a bond Me a bond NH O NH T3fOH 1707 CH S Q1b a bond Me a bond NH O NH T3g OH 1708 CH S Q1b a bond Mea bond NH O NH T3h OH 1709 CH S Q1b a bond Me a bond NH O NH T3i OH 1710CH S Q1b a bond Me a bond NH O NH T3j OH 1711 CH S Q1b a bond Me a bondNH O a bond T3a OH 1712 CH S Q1b a bond Me a bond NH O a bond T3b OH1713 CH S Q1b a bond Me a bond NH O a bond T3c OH 1714 CH S Q1b a bondMe a bond NH O a bond T3d OH 1715 CH S Q1b a bond Me a bond NH O a bondT3e OH 1716 CH S Q1b a bond Me a bond NH O a bond T3f OH 1717 CH S Q1b abond Me a bond NH O a bond T3g OH 1718 CH S Q1b a bond Me a bond NH O abond T3h OH 1719 CH S Q1b a bond Me a bond NH O a bond T3i OH 1720 CH SQ1b a bond Me a bond NH O a bond T3j OH 1721 CH S Q1b a bond H a bond NHS NH T3a OH 1722 CH S Q1b a bond H a bond NH S NH T3b OH 1723 CH S Q1b abond H a bond NH S NH T3c OH 1724 CH S Q1b a bond H a bond NH S NH T3dOH 1725 CH S Q1b a bond H a bond NH S NH T3e OH 1726 CH S Q1b a bond H abond NH S NH T3f OH 1727 CH S Q1b a bond H a bond NH S NH T3g OH 1728 CHS Q1b a bond H a bond NH S NH T3h OH 1729 CH S Q1b a bond H a bond NH SNH T3i OH 1730 CH S Q1b a bond H a bond NH S NH T3j OH 1731 CH S Q1b abond H a bond NH S a bond T3a OH 1732 CH S Q1b a bond H a bond NH S abond T3b OH 1733 CH S Q1b a bond H a bond NH S a bond T3c OH 1734 CH SQ1b a bond H a bond NH S a bond T3d OH 1735 CH S Q1b a bond H a bond NHS a bond T3e OH 1736 CH S Q1b a bond H a bond NH S a bond T3f OH 1737 CHS Q1b a bond H a bond NH S a bond T3g OH 1738 CH S Q1b a bond H a bondNH S a bond T3h OH 1739 CH S Q1b a bond H a bond NH S a bond T3i OH 1740CH S Q1b a bond H a bond NH S a bond T3j OH 1741 CH S Q1b a bond H abond NH O NH T3a OH 1742 CH S Q1b a bond H a bond NH O NH T3b OH 1743 CHS Q1b a bond H a bond NH O NH T3c OH 1744 CH S Q1b a bond H a bond NH ONH T3d OH 1745 CH S Q1b a bond H a bond NH O NH T3e OH 1746 CH S Q1b abond H a bond NH O NH T3f OH 1747 CH S Q1b a bond H a bond NH O NH T3gOH 1748 CH S Q1b a bond H a bond NH O NH T3h OH 1749 CH S Q1b a bond H abond NH O NH T3i OH 1750 CH S Q1b a bond H a bond NH O NH T3j OH 1751 CHS Q1b a bond H a bond NH O a bond T3a OH 1752 CH S Q1b a bond H a bondNH O a bond T3b OH 1753 CH S Q1b a bond H a bond NH O a bond T3c OH 1754CH S Q1b a bond H a bond NH O a bond T3d OH 1755 CH S Q1b a bond H abond NH O a bond T3e OH 1756 CH S Q1b a bond H a bond NH O a bond T3f OH1757 CH S Q1b a bond H a bond NH O a bond T3g OH 1758 CH S Q1b a bond Ha bond NH O a bond T3h OH 1759 CH S Q1b a bond H a bond NH O a bond T3iOH 1760 CH S Q1b a bond H a bond NH O a bond T3j OH 1761 CH S Q1c a bondMe a bond NH S NH T3a OH 1762 CH S Q1c a bond Me a bond NH S NH T3b OH1763 CH S Q1c a bond Me a bond NH S NH T3c OH 1764 CH S Q1c a bond Me abond NH S NH T3d OH 1765 CH S Q1c a bond Me a bond NH S NH T3e OH 1766CH S Q1c a bond Me a bond NH S NH T3f OH 1767 CH S Q1c a bond Me a bondNH S NH T3g OH 1768 CH S Q1c a bond Me a bond NH S NH T3h OH 1769 CH SQ1c a bond Me a bond NH S NH T3i OH 1770 CH S Q1c a bond Me a bond NH SNH T3j OH 1771 CH S Q1c a bond Me a bond NH S a bond T3a OH 1772 CH SQ1c a bond Me a bond NH S a bond T3b OH 1773 CH S Q1c a bond Me a bondNH S a bond T3c OH 1774 CH S Q1c a bond Me a bond NH S a bond T3d OH1775 CH S Q1c a bond Me a bond NH S a bond T3e OH 1776 CH S Q1c a bondMe a bond NH S a bond T3f OH 1777 CH S Q1c a bond Me a bond NH S a bondT3g OH 1778 CH S Q1c a bond Me a bond NH S a bond T3h OH 1779 CH S Q1c abond Me a bond NH S a bond T3i OH 1780 CH S Q1c a bond Me a bond NH S abond T3j OH 1781 CH S Q1c a bond Me a bond NH O NH T3a OH 1782 CH S Q1ca bond Me a bond NH O NH T3b OH 1783 CH S Q1c a bond Me a bond NH O NHT3c OH 1784 CH S Q1c a bond Me a bond NH O NH T3d OH 1785 CH S Q1c abond Me a bond NH O NH T3e OH 1786 CH S Q1c a bond Me a bond NH O NH T3fOH 1787 CH S Q1c a bond Me a bond NH O NH T3g OH 1788 CH S Q1c a bond Mea bond NH O NH T3h OH 1789 CH S Q1c a bond Me a bond NH O NH T3i OH 1790CH S Q1c a bond Me a bond NH O NH T3j OH 1791 CH S Q1c a bond Me a bondNH O a bond T3a OH 1792 CH S Q1c a bond Me a bond NH O a bond T3b OH1793 CH S Q1c a bond Me a bond NH O a bond T3c OH 1794 CH S Q1c a bondMe a bond NH O a bond T3d OH 1795 CH S Q1c a bond Me a bond NH O a bondT3e OH 1796 CH S Q1c a bond Me a bond NH O a bond T3f OH 1797 CH S Q1c abond Me a bond NH O a bond T3g OH 1798 CH S Q1c a bond Me a bond NH O abond T3h OH 1799 CH S Q1c a bond Me a bond NH O a bond T3i OH 1800 CH SQ1c a bond Me a bond NH O a bond T3j OH 1801 CH S Q1c a bond H a bond NHS NH T3a OH 1802 CH S Q1c a bond H a bond NH S NH T3b OH 1803 CH S Q1c abond H a bond NH S NH T3c OH 1804 CH S Q1c a bond H a bond NH S NH T3dOH 1805 CH S Q1c a bond H a bond NH S NH T3e OH 1806 CH S Q1c a bond H abond NH S NH T3f OH 1807 CH S Q1c a bond H a bond NH S NH T3g OH 1808 CHS Q1c a bond H a bond NH S NH T3h OH 1809 CH S Q1c a bond H a bond NH SNH T3i OH 1810 CH S Q1c a bond H a bond NH S NH T3j OH 1811 CH S Q1c abond H a bond NH S a bond T3a OH 1812 CH S Q1c a bond H a bond NH S abond T3b OH 1813 CH S Q1c a bond H a bond NH S a bond T3c OH 1814 CH SQ1c a bond H a bond NH S a bond T3d OH 1815 CH S Q1c a bond H a bond NHS a bond T3e OH 1816 CH S Q1c a bond H a bond NH S a bond T3f OH 1817 CHS Q1c a bond H a bond NH S a bond T3g OH 1818 CH S Q1c a bond H a bondNH S a bond T3h OH 1819 CH S Q1c a bond H a bond NH S a bond T3i OH 1820CH S Q1c a bond H a bond NH S a bond T3j OH 1821 CH S Q1c a bond H abond NH O NH T3a OH 1822 CH S Q1c a bond H a bond NH O NH T3b OH 1823 CHS Q1c a bond H a bond NH O NH T3c OH 1824 CH S Q1c a bond H a bond NH ONH T3d OH 1825 CH S Q1c a bond H a bond NH O NH T3e OH 1826 CH S Q1c abond H a bond NH O NH T3f OH 1827 CH S Q1c a bond H a bond NH O NH T3gOH 1828 CH S Q1c a bond H a bond NH O NH T3h OH 1829 CH S Q1c a bond H abond NH O NH T3i OH 1830 CH S Q1c a bond H a bond NH O NH T3j OH 1831 CHS Q1c a bond H a bond NH O a bond T3a OH 1832 CH S Q1c a bond H a bondNH O a bond T3b OH 1833 CH S Q1c a bond H a bond NH O a bond T3c OH 1834CH S Q1c a bond H a bond NH O a bond T3d OH 1835 CH S Q1c a bond H abond NH O a bond T3e OH 1836 CH S Q1c a bond H a bond NH O a bond T3f OH1837 CH S Q1c a bond H a bond NH O a bond T3g OH 1838 CH S Q1c a bond Ha bond NH O a bond T3h OH 1839 CH S Q1c a bond H a bond NH O a bond T3iOH 1840 CH S Q1c a bond H a bond NH O a bond T3j OH 1841 CH S Q1i a bondMe a bond NH S NH T3a OH 1842 CH S Q1i a bond Me a bond NH S NH T3b OH1843 CH S Q1i a bond Me a bond NH S NH T3c OH 1844 CH S Q1i a bond Me abond NH S NH T3d OH 1845 CH S Q1i a bond Me a bond NH S NH T3e OH 1846CH S Q1i a bond Me a bond NH S NH T3f OH 1847 CH S Q1i a bond Me a bondNH S NH T3g OH 1848 CH S Q1i a bond Me a bond NH S NH T3h OH 1849 CH SQ1i a bond Me a bond NH S NH T3i OH 1850 CH S Q1i a bond Me a bond NH SNH T3j OH 1851 CH S Q1i a bond Me a bond NH S a bond T3a OH 1852 CH SQ1i a bond Me a bond NH S a bond T3b OH 1853 CH S Q1i a bond Me a bondNH S a bond T3c OH 1854 CH S Q1i a bond Me a bond NH S a bond T3d OH1855 CH S Q1i a bond Me a bond NH S a bond T3e OH 1856 CH S Q1i a bondMe a bond NH S a bond T3f OH 1857 CH S Q1i a bond Me a bond NH S a bondT3g OH 1858 CH S Q1i a bond Me a bond NH S a bond T3h OH 1859 CH S Q1i abond Me a bond NH S a bond T3i OH 1860 CH S Q1i a bond Me a bond NH S abond T3j OH 1861 CH S Q1i a bond Me a bond NH O NH T3a OH 1862 CH S Q1ia bond Me a bond NH O NH T3b OH 1863 CH S Q1i a bond Me a bond NH O NHT3c OH 1864 CH S Q1i a bond Me a bond NH O NH T3d OH 1865 CH S Q1i abond Me a bond NH O NH T3e OH 1866 CH S Q1i a bond Me a bond NH O NH T3fOH 1867 CH S Q1i a bond Me a bond NH O NH T3g OH 1868 CH S Q1i a bond Mea bond NH O NH T3h OH 1869 CH S Q1i a bond Me a bond NH O NH T3i OH 1870CH S Q1i a bond Me a bond NH O NH T3j OH 1871 CH S Q1i a bond Me a bondNH O a bond T3a OH 1872 CH S Q1i a bond Me a bond NH O a bond T3b OH1873 CH S Q1i a bond Me a bond NH O a bond T3c OH 1874 CH S Q1i a bondMe a bond NH O a bond T3d OH 1875 CH S Q1i a bond Me a bond NH O a bondT3e OH 1876 CH S Q1i a bond Me a bond NH O a bond T3f OH 1877 CH S Q1i abond Me a bond NH O a bond T3g OH 1878 CH S Q1i a bond Me a bond NH O abond T3h OH 1879 CH S Q1i a bond Me a bond NH O a bond T3i OH 1880 CH SQ1i a bond Me a bond NH O a bond T3j OH 1881 CH S Q1i a bond H a bond NHS NH T3a OH 1882 CH S Q1i a bond H a bond NH S NH T3b OH 1883 CH S Q1i abond H a bond NH S NH T3c OH 1884 CH S Q1i a bond H a bond NH S NH T3dOH 1885 CH S Q1i a bond H a bond NH S NH T3e OH 1886 CH S Q1i a bond H abond NH S NH T3f OH 1887 CH S Q1i a bond H a bond NH S NH T3g OH 1888 CHS Q1i a bond H a bond NH S NH T3h OH 1889 CH S Q1i a bond H a bond NH SNH T3i OH 1890 CH S Q1i a bond H a bond NH S NH T3j OH 1891 CH S Q1i abond H a bond NH S a bond T3a OH 1892 CH S Q1i a bond H a bond NH S abond T3b OH 1893 CH S Q1i a bond H a bond NH S a bond T3c OH 1894 CH SQ1i a bond H a bond NH S a bond T3d OH 1895 CH S Q1i a bond H a bond NHS a bond T3e OH 1896 CH S Q1i a bond H a bond NH S a bond T3f OH 1897 CHS Q1i a bond H a bond NH S a bond T3g OH 1898 CH S Q1i a bond H a bondNH S a bond T3h OH 1899 CH S Q1i a bond H a bond NH S a bond T3i OH 1900CH S Q1i a bond H a bond NH S a bond T3j OH 1901 CH S Q1i a bond H abond NH O NH T3a OH 1902 CH S Q1i a bond H a bond NH O NH T3b OH 1903 CHS Q1i a bond H a bond NH O NH T3c OH 1904 CH S Q1i a bond H a bond NH ONH T3d OH 1905 CH S Q1i a bond H a bond NH O NH T3e OH 1906 CH S Q1i abond H a bond NH O NH T3f OH 1907 CH S Q1i a bond H a bond NH O NH T3gOH 1908 CH S Q1i a bond H a bond NH O NH T3h OH 1909 CH S Q1i a bond H abond NH O NH T3i OH 1910 CH S Q1i a bond H a bond NH O NH T3j OH 1911 CHS Q1i a bond H a bond NH O a bond T3a OH 1912 CH S Q1i a bond H a bondNH O a bond T3b OH 1913 CH S Q1i a bond H a bond NH O a bond T3c OH 1914CH S Q1i a bond H a bond NH O a bond T3d OH 1915 CH S Q1i a bond H abond NH O a bond T3e OH 1916 CH S Q1i a bond H a bond NH O a bond T3f OH1917 CH S Q1i a bond H a bond NH O a bond T3g OH 1918 CH S Q1i a bond Ha bond NH O a bond T3h OH 1919 CH S Q1i a bond H a bond NH O a bond T3iOH 1920 CH S Q1i a bond H a bond NH O a bond T3j OH 1921 CH S Q1j a bondMe a bond NH S NH T3a OH 1922 CH S Q1j a bond Me a bond NH S NH T3b OH1923 CH S Q1j a bond Me a bond NH S NH T3c OH 1924 CH S Q1j a bond Me abond NH S NH T3d OH 1925 CH S Q1j a bond Me a bond NH S NH T3e OH 1926CH S Q1j a bond Me a bond NH S NH T3f OH 1927 CH S Q1j a bond Me a bondNH S NH T3g OH 1928 CH S Q1j a bond Me a bond NH S NH T3h OH 1929 CH SQ1j a bond Me a bond NH S NH T3i OH 1930 CH S Q1j a bond Me a bond NH SNH T3j OH 1931 CH S Q1j a bond Me a bond NH S a bond T3a OH 1932 CH SQ1j a bond Me a bond NH S a bond T3b OH 1933 CH S Q1j a bond Me a bondNH S a bond T3c OH 1934 CH S Q1j a bond Me a bond NH S a bond T3d OH1935 CH S Q1j a bond Me a bond NH S a bond T3e OH 1936 CH S Q1j a bondMe a bond NH S a bond T3f OH 1937 CH S Q1j a bond Me a bond NH S a bondT3g OH 1938 CH S Q1j a bond Me a bond NH S a bond T3h OH 1939 CH S Q1j abond Me a bond NH S a bond T3i OH 1940 CH S Q1j a bond Me a bond NH S abond T3j OH 1941 CH S Q1j a bond Me a bond NH O NH T3a OH 1942 CH S Q1ja bond Me a bond NH O NH T3b OH 1943 CH S Q1j a bond Me a bond NH O NHT3c OH 1944 CH S Q1j a bond Me a bond NH O NH T3d OH 1945 CH S Q1j abond Me a bond NH O NH T3e OH 1946 CH S Q1j a bond Me a bond NH O NH T3fOH 1947 CH S Q1j a bond Me a bond NH O NH T3g OH 1948 CH S Q1j a bond Mea bond NH O NH T3h OH 1949 CH S Q1j a bond Me a bond NH O NH T3i OH 1950CH S Q1j a bond Me a bond NH O NH T3j OH 1951 CH S Q1j a bond Me a bondNH O a bond T3a OH 1952 CH S Q1j a bond Me a bond NH O a bond T3b OH1953 CH S Q1j a bond Me a bond NH O a bond T3c OH 1954 CH S Q1j a bondMe a bond NH O a bond T3d OH 1955 CH S Q1j a bond Me a bond NH O a bondT3e OH 1956 CH S Q1j a bond Me a bond NH O a bond T3f OH 1957 CH S Q1j abond Me a bond NH O a bond T3g OH 1958 CH S Q1j a bond Me a bond NH O abond T3h OH 1959 CH S Q1j a bond Me a bond NH O a bond T3i OH 1960 CH SQ1j a bond Me a bond NH O a bond T3j OH 1961 CH S Q1j a bond H a bond NHS NH T3a OH 1962 CH S Q1j a bond H a bond NH S NH T3b OH 1963 CH S Q1j abond H a bond NH S NH T3c OH 1964 CH S Q1j a bond H a bond NH S NH T3dOH 1965 CH S Q1j a bond H a bond NH S NH T3e OH 1966 CH S Q1j a bond H abond NH S NH T3f OH 1967 CH S Q1j a bond H a bond NH S NH T3g OH 1968 CHS Q1j a bond H a bond NH S NH T3h OH 1969 CH S Q1j a bond H a bond NH SNH T3i OH 1970 CH S Q1j a bond H a bond NH S NH T3j OH 1971 CH S Q1j abond H a bond NH S a bond T3a OH 1972 CH S Q1j a bond H a bond NH S abond T3b OH 1973 CH S Q1j a bond H a bond NH S a bond T3c OH 1974 CH SQ1j a bond H a bond NH S a bond T3d OH 1975 CH S Q1j a bond H a bond NHS a bond T3e OH 1976 CH S Q1j a bond H a bond NH S a bond T3f OH 1977 CHS Q1j a bond H a bond NH S a bond T3g OH 1978 CH S Q1i a bond H a bondNH S a bond T3h OH 1979 CH S Q1j a bond H a bond NH S a bond T3i OH 1980CH S Q1j a bond H a bond NH S a bond T3j OH 1981 CH S Q1j a bond H abond NH O NH T3a OH 1982 CH S Q1j a bond H a bond NH O NH T3b OH 1983 CHS Q1j a bond H a bond NH O NH T3c OH 1984 CH S Q1j a bond H a bond NH ONH T3d OH 1985 CH S Q1j a bond H a bond NH O NH T3e OH 1986 CH S Q1j abond H a bond NH O NH T3f OH 1987 CH S Q1j a bond H a bond NH O NH T3gOH 1988 CH S Q1j a bond H a bond NH O NH T3h OH 1989 CH S Q1j a bond H abond NH O NH T3i OH 1990 CH S Q1j a bond H a bond NH O NH T3j OH 1991 CHS Q1j a bond H a bond NH O a bond T3a OH 1992 CH S Q1j a bond H a bondNH O a bond T3b OH 1993 CH S Q1j a bond H a bond NH O a bond T3c OH 1994CH S Q1j a bond H a bond NH O a bond T3d OH 1995 CH S Q1j a bond H abond NH O a bond T3e OH 1996 CH S Q1j a bond H a bond NH O a bond T3f OH1997 CH S Q1j a bond H a bond NH O a bond T3g OH 1998 CH S Q1j a bond Ha bond NH O a bond T3h OH 1999 CH S Q1j a bond H a bond NH O a bond T3iOH 2000 CH S Q1j a bond H a bond NH O a bond T3j OH 2001 CH O Q1a a bondMe a bond NH S NH T3a OH 2002 CH O Q1a a bond Me a bond NH S NH T3b OH2003 CH O Q1a a bond Me a bond NH S NH T3c OH 2004 CH O Q1a a bond Me abond NH S NH T3d OH 2005 CH O Q1a a bond Me a bond NH S NH T3e OH 2006CH O Q1a a bond Me a bond NH S NH T3f OH 2007 CH O Q1a a bond Me a bondNH S NH T3g OH 2008 CH O Q1a a bond Me a bond NH S NH T3h OH 2009 CH OQ1a a bond Me a bond NH S NH T3i OH 2010 CH O Q1a a bond Me a bond NH SNH T3j OH 2011 CH O Q1a a bond Me a bond NH S a bond T3a OH 2012 CH OQ1a a bond Me a bond NH S a bond T3b OH 2013 CH O Q1a a bond Me a bondNH S a bond T3c OH 2014 CH O Q1a a bond Me a bond NH S a bond T3d OH2015 CH O Q1a a bond Me a bond NH S a bond T3e OH 2016 CH O Q1a a bondMe a bond NH S a bond T3f OH 2017 CH O Q1a a bond Me a bond NH S a bondT3g OH 2018 CH O Q1a a bond Me a bond NH S a bond T3h OH 2019 CH O Q1a abond Me a bond NH S a bond T3i OH 2020 CH O Q1a a bond Me a bond NH S abond T3j OH 2021 CH O Q1a a bond Me a bond NH O NH T3a OH 2022 CH O Q1aa bond Me a bond NH O NH T3b OH 2023 CH O Q1a a bond Me a bond NH O NHT3c OH 2024 CH O Q1a a bond Me a bond NH O NH T3d OH 2025 CH O Q1a abond Me a bond NH O NH T3e OH 2026 CH O Q1a a bond Me a bond NH O NH T3fOH 2027 CH O Q1a a bond Me a bond NH O NH T3g OH 2028 CH O Q1a a bond Mea bond NH O NH T3h OH 2029 CH O Q1a a bond Me a bond NH O NH T3i OH 2030CH O Q1a a bond Me a bond NH O NH T3j OH 2031 CH O Q1a a bond Me a bondNH O a bond T3a OH 2032 CH O Q1a a bond Me a bond NH O a bond T3b OH2033 CH O Q1a a bond Me a bond NH O a bond T3c OH 2034 CH O Q1a a bondMe a bond NH O a bond T3d OH 2035 CH O Q1a a bond Me a bond NH O a bondT3e OH 2036 CH O Q1a a bond Me a bond NH O a bond T3f OH 2037 CH O Q1a abond Me a bond NH O a bond T3g OH 2038 CH O Q1a a bond Me a bond NH O abond T3h OH 2039 CH O Q1a a bond Me a bond NH O a bond T3i OH 2040 CH OQ1a a bond Me a bond NH O a bond T3j OH 2041 CH O Q1a a bond H a bond NHS NH T3a OH 2042 CH O Q1a a bond H a bond NH S NH T3b OH 2043 CH O Q1a abond H a bond NH S NH T3c OH 2044 CH O Q1a a bond H a bond NH S NH T3dOH 2045 CH O Q1a a bond H a bond NH S NH T3e OH 2046 CH O Q1a a bond H abond NH S NH T3f OH 2047 CH O Q1a a bond H a bond NH S NH T3g OH 2048 CHO Q1a a bond H a bond NH S NH T3h OH 2049 CH O Q1a a bond H a bond NH SNH T3i OH 2050 CH O Q1a a bond H a bond NH S NH T3j OH 2051 CH O Q1a abond H a bond NH S a bond T3a OH 2052 CH O Q1a a bond H a bond NH S abond T3b OH 2053 CH O Q1a a bond H a bond NH S a bond T3c OH 2054 CH OQ1a a bond H a bond NH S a bond T3d OH 2055 CH O Q1a a bond H a bond NHS a bond T3e OH 2056 CH O Q1a a bond H a bond NH S a bond T3f OH 2057 CHO Q1a a bond H a bond NH S a bond T3g OH 2058 CH O Q1a a bond H a bondNH S a bond T3h OH 2059 CH O Q1a a bond H a bond NH S a bond T3i OH 2060CH O Q1a a bond H a bond NH S a bond T3j OH 2061 CH O Q1a a bond H abond NH O NH T3a OH 2062 CH O Q1a a bond H a bond NH O NH T3b OH 2063 CHO Q1a a bond H a bond NH O NH T3c OH 2064 CH O Q1a a bond H a bond NH ONH T3d OH 2065 CH O Q1a a bond H a bond NH O NH T3e OH 2066 CH O Q1a abond H a bond NH O NH T3f OH 2067 CH O Q1a a bond H a bond NH O NH T3gOH 2068 CH O Q1a a bond H a bond NH O NH T3h OH 2069 CH O Q1a a bond H abond NH O NH T3i OH 2070 CH O Q1a a bond H a bond NH O NH T3j OH 2071 CHO Q1a a bond H a bond NH O a bond T3a OH 2072 CH O Q1a a bond H a bondNH O a bond T3b OH 2073 CH O Q1a a bond H a bond NH O a bond T3c OH 2074CH O Q1a a bond H a bond NH O a bond T3d OH 2075 CH O Q1a a bond H abond NH O a bond T3e OH 2076 CH O Q1a a bond H a bond NH O a bond T3f OH2077 CH O Q1a a bond H a bond NH O a bond T3g OH 2078 CH O Q1a a bond Ha bond NH O a bond T3h OH 2079 CH O Q1a a bond H a bond NH O a bond T3iOH 2080 CH O Q1a a bond H a bond NH O a bond T3j OH 2081 CH O Q1b a bondMe a bond NH S NH T3a OH 2082 CH O Q1b a bond Me a bond NH S NH T3b OH2083 CH O Q1b a bond Me a bond NH S NH T3c OH 2084 CH O Q1b a bond Me abond NH S NH T3d OH 2085 CH O Q1b a bond Me a bond NH S NH T3e OH 2086CH O Q1b a bond Me a bond NH S NH T3f OH 2087 CH O Q1b a bond Me a bondNH S NH T3g OH 2088 CH O Q1b a bond Me a bond NH S NH T3h OH 2089 CH OQ1b a bond Me a bond NH S NH T3i OH 2090 CH O Q1b a bond Me a bond NH SNH T3j OH 2091 CH O Q1b a bond Me a bond NH S a bond T3a OH 2092 CH OQ1b a bond Me a bond NH S a bond T3b OH 2093 CH O Q1b a bond Me a bondNH S a bond T3c OH 2094 CH O Q1b a bond Me a bond NH S a bond T3d OH2095 CH O Q1b a bond Me a bond NH S a bond T3e OH 2096 CH O Q1b a bondMe a bond NH S a bond T3f OH 2097 CH O Q1b a bond Me a bond NH S a bondT3g OH 2098 CH O Q1b a bond Me a bond NH S a bond T3h OH 2099 CH O Q1b abond Me a bond NH S a bond T3i OH 2100 CH O Q1b a bond Me a bond NH S abond T3j OH 2101 CH O Q1b a bond Me a bond NH O NH T3a OH 2102 CH O Q1ba bond Me a bond NH O NH T3b OH 2103 CH O Q1b a bond Me a bond NH O NHT3c OH 2104 CH O Q1b a bond Me a bond NH O NH T3d OH 2105 CH O Q1b abond Me a bond NH O NH T3e OH 2106 CH O Q1b a bond Me a bond NH O NH T3fOH 2107 CH O Q1b a bond Me a bond NH O NH T3g OH 2108 CH O Q1b a bond Mea bond NH O NH T3h OH 2109 CH O Q1b a bond Me a bond NH O NH T3i OH 2110CH O Q1b a bond Me a bond NH O NH T3j OH 2111 CH O Q1b a bond Me a bondNH O a bond T3a OH 2112 CH O Q1b a bond Me a bond NH O a bond T3b OH2113 CH O Q1b a bond Me a bond NH O a bond T3c OH 2114 CH O Q1b a bondMe a bond NH O a bond T3d OH 2115 CH O Q1b a bond Me a bond NH O a bondT3e OH 2116 CH O Q1b a bond Me a bond NH O a bond T3f OH 2117 CH O Q1b abond Me a bond NH O a bond T3g OH 2118 CH O Q1b a bond Me a bond NH O abond T3h OH 2119 CH O Q1b a bond Me a bond NH O a bond T3i OH 2120 CH OQ1b a bond Me a bond NH O a bond T3j OH 2121 CH O Q1b a bond H a bond NHS NH T3a OH 2122 CH O Q1b a bond H a bond NH S NH T3b OH 2123 CH O Q1b abond H a bond NH S NH T3c OH 2124 CH O Q1b a bond H a bond NH S NH T3dOH 2125 CH O Q1b a bond H a bond NH S NH T3e OH 2126 CH O Q1b a bond H abond NH S NH T3f OH 2127 CH O Q1b a bond H a bond NH S NH T3g OH 2128 CHO Q1b a bond H a bond NH S NH T3h OH 2129 CH O Q1b a bond H a bond NH SNH T3i OH 2130 CH O Q1b a bond H a bond NH S NH T3j OH 2131 CH O Q1b abond H a bond NH S a bond T3a OH 2132 CH O Q1b a bond H a bond NH S abond T3b OH 2133 CH O Q1b a bond H a bond NH S a bond T3c OH 2134 CH OQ1b a bond H a bond NH S a bond T3d OH 2135 CH O Q1b a bond H a bond NHS a bond T3e OH 2136 CH O Q1b a bond H a bond NH S a bond T3f OH 2137 CHO Q1b a bond H a bond NH S a bond T3g OH 2138 CH O Q1b a bond H a bondNH S a bond T3h OH 2139 CH O Q1b a bond H a bond NH S a bond T3i OH 2140CH O Q1b a bond H a bond NH S a bond T3j OH 2141 CH O Q1b a bond H abond NH O NH T3a OH 2142 CH O Q1b a bond H a bond NH O NH T3b OH 2143 CHO Q1b a bond H a bond NH O NH T3c OH 2144 CH O Q1b a bond H a bond NH ONH T3d OH 2145 CH O Q1b a bond H a bond NH O NH T3e OH 2146 CH O Q1b abond H a bond NH O NH T3f OH 2147 CH O Q1b a bond H a bond NH O NH T3gOH 2148 CH O Q1b a bond H a bond NH O NH T3h OH 2149 CH O Q1b a bond H abond NH O NH T3i OH 2150 CH O Q1b a bond H a bond NH O NH T3j OH 2151 CHO Q1b a bond H a bond NH O a bond T3a OH 2152 CH O Q1b a bond H a bondNH O a bond T3b OH 2153 CH O Q1b a bond H a bond NH O a bond T3c OH 2154CH O Q1b a bond H a bond NH O a bond T3d OH 2155 CH O Q1b a bond H abond NH O a bond T3e OH 2156 CH O Q1b a bond H a bond NH O a bond T3f OH2157 CH O Q1b a bond H a bond NH O a bond T3g OH 2158 CH O Q1b a bond Ha bond NH O a bond T3h OH 2159 CH O Q1b a bond H a bond NH O a bond T3iOH 2160 CH O Q1b a bond H a bond NH O a bond T3j OH 2161 CH O Q1c a bondMe a bond NH S NH T3a OH 2162 CH O Q1c a bond Me a bond NH S NH T3b OH2163 CH O Q1c a bond Me a bond NH S NH T3c OH 2164 CH O Q1c a bond Me abond NH S NH T3d OH 2165 CH O Q1c a bond Me a bond NH S NH T3e OH 2166CH O Q1c a bond Me a bond NH S NH T3f OH 2167 CH O Q1c a bond Me a bondNH S NH T3g OH 2168 CH O Q1c a bond Me a bond NH S NH T3h OH 2169 CH OQ1c a bond Me a bond NH S NH T3i OH 2170 CH O Q1c a bond Me a bond NH SNH T3j OH 2171 CH O Q1c a bond Me a bond NH S a bond T3a OH 2172 CH OQ1c a bond Me a bond NH S a bond T3b OH 2173 CH O Q1c a bond Me a bondNH S a bond T3c OH 2174 CH O Q1c a bond Me a bond NH S a bond T3d OH2175 CH O Q1c a bond Me a bond NH S a bond T3e OH 2176 CH O Q1c a bondMe a bond NH S a bond T3f OH 2177 CH O Q1c a bond Me a bond NH S a bondT3g OH 2178 CH O Q1c a bond Me a bond NH S a bond T3h OH 2179 CH O Q1c abond Me a bond NH S a bond T3i OH 2180 CH O Q1c a bond Me a bond NH S abond T3j OH 2181 CH O Q1c a bond Me a bond NH O NH T3a OH 2182 CH O Q1ca bond Me a bond NH O NH T3b OH 2183 CH O Q1c a bond Me a bond NH O NHT3c OH 2184 CH O Q1c a bond Me a bond NH O NH T3d OH 2185 CH O Q1c abond Me a bond NH O NH T3e OH 2186 CH O Q1c a bond Me a bond NH O NH T3fOH 2187 CH O Q1c a bond Me a bond NH O NH T3g OH 2188 CH O Q1c a bond Mea bond NH O NH T3h OH 2189 CH O Q1c a bond Me a bond NH O NH T3i OH 2190CH O Q1c a bond Me a bond NH O NH T3j OH 2191 CH O Q1c a bond Me a bondNH O a bond T3a OH 2192 CH O Q1c a bond Me a bond NH O a bond T3b OH2193 CH O Q1c a bond Me a bond NH O a bond T3c OH 2194 CH O Q1c a bondMe a bond NH O a bond T3d OH 2195 CH O Q1c a bond Me a bond NH O a bondT3e OH 2196 CH O Q1c a bond Me a bond NH O a bond T3f OH 2197 CH O Q1c abond Me a bond NH O a bond T3g OH 2198 CH O Q1c a bond Me a bond NH O abond T3h OH 2199 CH O Q1c a bond Me a bond NH O a bond T3i OH 2200 CH OQ1c a bond Me a bond NH O a bond T3j OH 2201 CH O Q1c a bond H a bond NHS NH T3a OH 2202 CH O Q1c a bond H a bond NH S NH T3b OH 2203 CH O Q1c abond H a bond NH S NH T3c OH 2204 CH O Q1c a bond H a bond NH S NH T3dOH 2205 CH O Q1c a bond H a bond NH S NH T3e OH 2206 CH O Q1c a bond H abond NH S NH T3f OH 2207 CH O Q1c a bond H a bond NH S NH T3g OH 2208 CHO Q1c a bond H a bond NH S NH T3h OH 2209 CH O Q1c a bond H a bond NH SNH T3i OH 2210 CH O Q1c a bond H a bond NH S NH T3j OH 2211 CH O Q1c abond H a bond NH S a bond T3a OH 2212 CH O Q1c a bond H a bond NH S abond T3b OH 2213 CH O Q1c a bond H a bond NH S a bond T3c OH 2214 CH OQ1c a bond H a bond NH S a bond T3d OH 2215 CH O Q1c a bond H a bond NHS a bond T3e OH 2216 CH O Q1c a bond H a bond NH S a bond T3f OH 2217 CHO Q1c a bond H a bond NH S a bond T3g OH 2218 CH O Q1c a bond H a bondNH S a bond T3h OH 2219 CH O Q1c a bond H a bond NH S a bond T3i OH 2220CH O Q1c a bond H a bond NH S a bond T3j OH 2221 CH O Q1c a bond H abond NH O NH T3a OH 2222 CH O Q1c a bond H a bond NH O NH T3b OH 2223 CHO Q1c a bond H a bond NH O NH T3c OH 2224 CH O Q1c a bond H a bond NH ONH T3d OH 2225 CH O Q1c a bond H a bond NH O NH T3e OH 2226 CH O Q1c abond H a bond NH O NH T3f OH 2227 CH O Q1c a bond H a bond NH O NH T3gOH 2228 CH O Q1c a bond H a bond NH O NH T3h OH 2229 CH O Q1c a bond H abond NH O NH T3i OH 2230 CH O Q1c a bond H a bond NH O NH T3j OH 2231 CHO Q1c a bond H a bond NH O a bond T3a OH 2232 CH O Q1c a bond H a bondNH O a bond T3b OH 2233 CH O Q1c a bond H a bond NH O a bond T3c OH 2234CH O Q1c a bond H a bond NH O a bond T3d OH 2235 CH O Q1c a bond H abond NH O a bond T3e OH 2236 CH O Q1c a bond H a bond NH O a bond T3f OH2237 CH O Q1c a bond H a bond NH O a bond T3g OH 2238 CH O Q1c a bond Ha bond NH O a bond T3h OH 2239 CH O Q1c a bond H a bond NH O a bond T3iOH 2240 CH O Q1c a bond H a bond NH O a bond T3j OH 2241 CH O Q1i a bondMe a bond NH S NH T3a OH 2242 CH O Q1i a bond Me a bond NH S NH T3b OH2243 CH O Q1i a bond Me a bond NH S NH T3c OH 2244 CH O Q1i a bond Me abond NH S NH T3d OH 2245 CH O Q1i a bond Me a bond NH S NH T3e OH 2246CH O Q1i a bond Me a bond NH S NH T3f OH 2247 CH O Q1i a bond Me a bondNH S NH T3g OH 2248 CH O Q1i a bond Me a bond NH S NH T3h OH 2249 CH OQ1i a bond Me a bond NH S NH T3i OH 2250 CH O Q1i a bond Me a bond NH SNH T3j OH 2251 CH O Q1i a bond Me a bond NH S a bond T3a OH 2252 CH OQ1i a bond Me a bond NH S a bond T3b OH 2253 CH O Q1i a bond Me a bondNH S a bond T3c OH 2254 CH O Q1i a bond Me a bond NH S a bond T3d OH2255 CH O Q1i a bond Me a bond NH S a bond T3e OH 2256 CH O Q1i a bondMe a bond NH S a bond T3f OH 2257 CH O Q1i a bond Me a bond NH S a bondT3g OH 2258 CH O Q1i a bond Me a bond NH S a bond T3h OH 2259 CH O Q1i abond Me a bond NH S a bond T3i OH 2260 CH O Q1i a bond Me a bond NH S abond T3j OH 2261 CH O Q1i a bond Me a bond NH O NH T3a OH 2262 CH O Q1ia bond Me a bond NH O NH T3b OH 2263 CH O Q1i a bond Me a bond NH O NHT3c OH 2264 CH O Q1i a bond Me a bond NH O NH T3d OH 2265 CH O Q1i abond Me a bond NH O NH T3e OH 2266 CH O Q1i a bond Me a bond NH O NH T3fOH 2267 CH O Q1i a bond Me a bond NH O NH T3g OH 2268 CH O Q1i a bond Mea bond NH O NH T3h OH 2269 CH O Q1i a bond Me a bond NH O NH T3i OH 2270CH O Q1i a bond Me a bond NH O NH T3j OH 2271 CH O Q1i a bond Me a bondNH O a bond T3a OH 2272 CH O Q1i a bond Me a bond NH O a bond T3b OH2273 CH O Q1i a bond Me a bond NH O a bond T3c OH 2274 CH O Q1i a bondMe a bond NH O a bond T3d OH 2275 CH O Q1i a bond Me a bond NH O a bondT3e OH 2276 CH O Q1i a bond Me a bond NH O a bond T3f OH 2277 CH O Q1i abond Me a bond NH O a bond T3g OH 2278 CH O Q1i a bond Me a bond NH O abond T3h OH 2279 CH O Q1i a bond Me a bond NH O a bond T3i OH 2280 CH OQ1i a bond Me a bond NH O a bond T3j OH 2281 CH O Q1i a bond H a bond NHS NH T3a OH 2282 CH O Q1i a bond H a bond NH S NH T3b OH 2283 CH O Q1i abond H a bond NH S NH T3c OH 2284 CH O Q1i a bond H a bond NH S NH T3dOH 2285 CH O Q1i a bond H a bond NH S NH T3e OH 2286 CH O Q1i a bond H abond NH S NH T3f OH 2287 CH O Q1i a bond H a bond NH S NH T3g OH 2288 CHO Q1i a bond H a bond NH S NH T3h OH 2289 CH O Q1i a bond H a bond NH SNH T3i OH 2290 CH O Q1i a bond H a bond NH S NH T3j OH 2291 CH O Q1i abond H a bond NH S a bond T3a OH 2292 CH O Q1i a bond H a bond NH S abond T3b OH 2293 CH O Q1i a bond H a bond NH S a bond T3c OH 2294 CH OQ1i a bond H a bond NH S a bond T3d OH 2295 CH O Q1i a bond H a bond NHS a bond T3e OH 2296 CH O Q1i a bond H a bond NH S a bond T3f OH 2297 CHO Q1i a bond H a bond NH S a bond T3g OH 2298 CH O Q1i a bond H a bondNH S a bond T3h OH 2299 CH O Q1i a bond H a bond NH S a bond T3i OH 2300CH O Q1i a bond H a bond NH S a bond T3j OH 2301 CH O Q1i a bond H abond NH O NH T3a OH 2302 CH O Q1i a bond H a bond NH O NH T3b OH 2303 CHO Q1i a bond H a bond NH O NH T3c OH 2304 CH O Q1i a bond H a bond NH ONH T3d OH 2305 CH O Q1i a bond H a bond NH O NH T3e OH 2306 CH O Q1i abond H a bond NH O NH T3f OH 2307 CH O Q1i a bond H a bond NH O NH T3gOH 2308 CH O Q1i a bond H a bond NH O NH T3h OH 2309 CH O Q1i a bond H abond NH O NH T3i OH 2310 CH O Q1i a bond H a bond NH O NH T3j OH 2311 CHO Q1i a bond H a bond NH O a bond T3a OH 2312 CH O Q1i a bond H a bondNH O a bond T3b OH 2313 CH O Q1i a bond H a bond NH O a bond T3c OH 2314CH O Q1i a bond H a bond NH O a bond T3d OH 2315 CH O Q1i a bond H abond NH O a bond T3e OH 2316 CH O Q1i a bond H a bond NH O a bond T3f OH2317 CH O Q1i a bond H a bond NH O a bond T3g OH 2318 CH O Q1i a bond Ha bond NH O a bond T3h OH 2319 CH O Q1i a bond H a bond NH O a bond T3iOH 2320 CH O Q1i a bond H a bond NH O a bond T3j OH 2321 CH O Q1j a bondMe a bond NH S NH T3a OH 2322 CH O Q1j a bond Me a bond NH S NH T3b OH2323 CH O Q1j a bond Me a bond NH S NH T3c OH 2324 CH O Q1j a bond Me abond NH S NH T3d OH 2325 CH O Q1j a bond Me a bond NH S NH T3e OH 2326CH O Q1j a bond Me a bond NH S NH T3f OH 2327 CH O Q1j a bond Me a bondNH S NH T3g OH 2328 CH O Q1j a bond Me a bond NH S NH T3h OH 2329 CH OQ1j a bond Me a bond NH S NH T3i OH 2330 CH O Q1j a bond Me a bond NH SNH T3j OH 2331 CH O Q1j a bond Me a bond NH S a bond T3a OH 2332 CH OQ1j a bond Me a bond NH S a bond T3b OH 2333 CH O Q1j a bond Me a bondNH S a bond T3c OH 2334 CH O Q1j a bond Me a bond NH S a bond T3d OH2335 CH O Q1j a bond Me a bond NH S a bond T3e OH 2336 CH O Q1j a bondMe a bond NH S a bond T3f OH 2337 CH O Q1j a bond Me a bond NH S a bondT3g OH 2338 CH O Q1j a bond Me a bond NH S a bond T3h OH 2339 CH O Q1j abond Me a bond NH S a bond T3i OH 2340 CH O Q1j a bond Me a bond NH S abond T3j OH 2341 CH O Q1j a bond Me a bond NH O NH T3a OH 2342 CH O Q1ja bond Me a bond NH O NH T3b OH 2343 CH O Q1j a bond Me a bond NH O NHT3c OH 2344 CH O Q1j a bond Me a bond NH O NH T3d OH 2345 CH O Q1j abond Me a bond NH O NH T3e OH 2346 CH O Q1j a bond Me a bond NH O NH T3fOH 2347 CH O Q1j a bond Me a bond NH O NH T3g OH 2348 CH O Q1j a bond Mea bond NH O NH T3h OH 2349 CH O Q1j a bond Me a bond NH O NH T3i OH 2350CH O Q1j a bond Me a bond NH O NH T3j OH 2351 CH O Q1j a bond Me a bondNH O a bond T3a OH 2352 CH O Q1j a bond Me a bond NH O a bond T3b OH2353 CH O Q1j a bond Me a bond NH O a bond T3c OH 2354 CH O Q1j a bondMe a bond NH O a bond T3d OH 2355 CH O Q1j a bond Me a bond NH O a bondT3e OH 2356 CH O Q1j a bond Me a bond NH O a bond T3f OH 2357 CH O Q1j abond Me a bond NH O a bond T3g OH 2358 CH O Q1j a bond Me a bond NH O abond T3h OH 2359 CH O Q1j a bond Me a bond NH O a bond T3i OH 2360 CH OQ1j a bond Me a bond NH O a bond T3j OH 2361 CH O Q1j a bond H a bond NHS NH T3a OH 2362 CH O Q1j a bond H a bond NH S NH T3b OH 2363 CH O Q1j abond H a bond NH S NH T3c OH 2364 CH O Q1j a bond H a bond NH S NH T3dOH 2365 CH O Q1j a bond H a bond NH S NH T3e OH 2366 CH O Q1j a bond H abond NH S NH T3f OH 2367 CH O Q1j a bond H a bond NH S NH T3g OH 2368 CHO Q1j a bond H a bond NH S NH T3h OH 2369 CH O Q1j a bond H a bond NH SNH T3i OH 2370 CH O Q1j a bond H a bond NH S NH T3j OH 2371 CH O Q1j abond H a bond NH S a bond T3a OH 2372 CH O Q1j a bond H a bond NH S abond T3b OH 2373 CH O Q1j a bond H a bond NH S a bond T3c OH 2374 CH OQ1j a bond H a bond NH S a bond T3d OH 2375 CH O Q1j a bond H a bond NHS a bond T3e OH 2376 CH O Q1j a bond H a bond NH S a bond T3f OH 2377 CHO Q1j a bond H a bond NH S a bond T3g OH 2378 CH O Q1j a bond H a bondNH S a bond T3h OH 2379 CH O Q1j a bond H a bond NH S a bond T3i OH 2380CH O Q1j a bond H a bond NH S a bond T3j OH 2381 CH O Q1j a bond H abond NH O NH T3a OH 2382 CH O Q1j a bond H a bond NH O NH T3b OH 2383 CHO Q1j a bond H a bond NH O NH T3c OH 2384 CH O Q1j a bond H a bond NH ONH T3d OH 2385 CH O Q1j a bond H a bond NH O NH T3e OH 2386 CH O Q1j abond H a bond NH O NH T3f OH 2387 CH O Q1j a bond H a bond NH O NH T3gOH 2388 CH O Q1j a bond H a bond NH O NH T3h OH 2389 CH O Q1j a bond H abond NH O NH T3i OH 2390 CH O Q1j a bond H a bond NH O NH T3j OH 2391 CHO Q1j a bond H a bond NH O a bond T3a OH 2392 CH O Q1j a bond H a bondNH O a bond T3b OH 2393 CH O Q1j a bond H a bond NH O a bond T3c OH 2394CH O Q1j a bond H a bond NH O a bond T3d OH 2395 CH O Q1j a bond H abond NH O a bond T3e OH 2396 CH O Q1j a bond H a bond NH O a bond T3f OH2397 CH O Q1j a bond H a bond NH O a bond T3g OH 2398 CH O Q1j a bond Ha bond NH O a bond T3h OH 2399 CH O Q1j a bond H a bond NH O a bond T3iOH 2400 CH O Q1j a bond H a bond NH O a bond T3j OH 2401 CMe NMe Q1a abond Me a bond NH S NH T3a OH 2402 CMe NMe Q1a a bond Me a bond NH S NHT3b OH 2403 CMe NMe Q1a a bond Me a bond NH S NH T3c OH 2404 CMe NMe Q1aa bond Me a bond NH S NH T3d OH 2405 CMe NMe Q1a a bond Me a bond NH SNH T3e OH 2406 CMe NMe Q1a a bond Me a bond NH S NH T3f OH 2407 CMe NMeQ1a a bond Me a bond NH S NH T3g OH 2408 CMe NMe Q1a a bond Me a bond NHS NH T3h OH 2409 CMe NMe Q1a a bond Me a bond NH S NH T3i OH 2410 CMeNMe Q1a a bond Me a bond NH S NH T3j OH 2411 CMe NMe Q1a a bond Me abond NH S a bond T3a OH 2412 CMe NMe Q1a a bond Me a bond NH S a bondT3b OH 2413 CMe NMe Q1a a bond Me a bond NH S a bond T3c OH 2414 CMe NMeQ1a a bond Me a bond NH S a bond T3d OH 2415 CMe NMe Q1a a bond Me abond NH S a bond T3e OH 2416 CMe NMe Q1a a bond Me a bond NH S a bondT3f OH 2417 CMe NMe Q1a a bond Me a bond NH S a bond T3g OH 2418 CMe NMeQ1a a bond Me a bond NH S a bond T3h OH 2419 CMe NMe Q1a a bond Me abond NH S a bond T3i OH 2420 CMe NMe Q1a a bond Me a bond NH S a bondT3j OH 2421 CMe NMe Q1a a bond Me a bond NH O NH T3a OH 2422 CMe NMe Q1aa bond Me a bond NH O NH T3b OH 2423 CMe NMe Q1a a bond Me a bond NH ONH T3c OH 2424 CMe NMe Q1a a bond Me a bond NH O NH T3d OH 2425 CMe NMeQ1a a bond Me a bond NH O NH T3e OH 2426 CMe NMe Q1a a bond Me a bond NHO NH T3f OH 2427 CMe NMe Q1a a bond Me a bond NH O NH T3g OH 2428 CMeNMe Q1a a bond Me a bond NH O NH T3h OH 2429 CMe NMe Q1a a bond Me abond NH O NH T3i OH 2430 CMe NMe Q1a a bond Me a bond NH O NH T3j OH2431 CMe NMe Q1a a bond Me a bond NH O a bond T3a OH 2432 CMe NMe Q1a abond Me a bond NH O a bond T3b OH 2433 CMe NMe Q1a a bond Me a bond NH Oa bond T3c OH 2434 CMe NMe Q1a a bond Me a bond NH O a bond T3d OH 2435CMe NMe Q1a a bond Me a bond NH O a bond T3e OH 2436 CMe NMe Q1a a bondMe a bond NH O a bond T3f OH 2437 CMe NMe Q1a a bond Me a bond NH O abond T3g OH 2438 CMe NMe Q1a a bond Me a bond NH O a bond T3h OH 2439CMe NMe Q1a a bond Me a bond NH O a bond T3i OH 2440 CMe NMe Q1a a bondMe a bond NH O a bond T3j OH 2441 CMe NMe Q1a a bond H a bond NH S NHT3a OH 2442 CMe NMe Q1a a bond H a bond NH S NH T3b OH 2443 CMe NMe Q1aa bond H a bond NH S NH T3c OH 2444 CMe NMe Q1a a bond H a bond NH S NHT3d OH 2445 CMe NMe Q1a a bond H a bond NH S NH T3e OH 2446 CMe NMe Q1aa bond H a bond NH S NH T3f OH 2447 CMe NMe Q1a a bond H a bond NH S NHT3g OH 2448 CMe NMe Q1a a bond H a bond NH S NH T3h OH 2449 CMe NMe Q1aa bond H a bond NH S NH T3i OH 2450 CMe NMe Q1a a bond H a bond NH S NHT3j OH 2451 CMe NMe Q1a a bond H a bond NH S a bond T3a OH 2452 CMe NMeQ1a a bond H a bond NH S a bond T3b OH 2453 CMe NMe Q1a a bond H a bondNH S a bond T3c OH 2454 CMe NMe Q1a a bond H a bond NH S a bond T3d OH2455 CMe NMe Q1a a bond H a bond NH S a bond T3e OH 2456 CMe NMe Q1a abond H a bond NH S a bond T3f OH 2457 CMe NMe Q1a a bond H a bond NH S abond T3g OH 2458 CMe NMe Q1a a bond H a bond NH S a bond T3h OH 2459 CMeNMe Q1a a bond H a bond NH S a bond T3i OH 2460 CMe NMe Q1a a bond H abond NH S a bond T3j OH 2461 CMe NMe Q1a a bond H a bond NH O NH T3a OH2462 CMe NMe Q1a a bond H a bond NH O NH T3b OH 2463 CMe NMe Q1a a bondH a bond NH O NH T3c OH 2464 CMe NMe Q1a a bond H a bond NH O NH T3d OH2465 CMe NMe Q1a a bond H a bond NH O NH T3e OH 2466 CMe NMe Q1a a bondH a bond NH O NH T3f OH 2467 CMe NMe Q1a a bond H a bond NH O NH T3g OH2468 CMe NMe Q1a a bond H a bond NH O NH T3h OH 2469 CMe NMe Q1a a bondH a bond NH O NH T3i OH 2470 CMe NMe Q1a a bond H a bond NH O NH T3j OH2471 CMe NMe Q1a a bond H a bond NH O a bond T3a OH 2472 CMe NMe Q1a abond H a bond NH O a bond T3b OH 2473 CMe NMe Q1a a bond H a bond NH O abond T3c OH 2474 CMe NMe Q1a a bond H a bond NH O a bond T3d OH 2475 CMeNMe Q1a a bond H a bond NH O a bond T3e OH 2476 CMe NMe Q1a a bond H abond NH O a bond T3f OH 2477 CMe NMe Q1a a bond H a bond NH O a bond T3gOH 2478 CMe NMe Q1a a bond H a bond NH O a bond T3h OH 2479 CMe NMe Q1aa bond H a bond NH O a bond T3i OH 2480 CMe NMe Q1a a bond H a bond NH Oa bond T3j OH 2481 CMe NMe Q1b a bond Me a bond NH S NH T3a OH 2482 CMeNMe Q1b a bond Me a bond NH S NH T3b OH 2483 CMe NMe Q1b a bond Me abond NH S NH T3c OH 2484 CMe NMe Q1b a bond Me a bond NH S NH T3d OH2485 CMe NMe Q1b a bond Me a bond NH S NH T3e OH 2486 CMe NMe Q1b a bondMe a bond NH S NH T3f OH 2487 CMe NMe Q1b a bond Me a bond NH S NH T3gOH 2488 CMe NMe Q1b a bond Me a bond NH S NH T3h OH 2489 CMe NMe Q1b abond Me a bond NH S NH T3i OH 2490 CMe NMe Q1b a bond Me a bond NH S NHT3j OH 2491 CMe NMe Q1b a bond Me a bond NH S a bond T3a OH 2492 CMe NMeQ1b a bond Me a bond NH S a bond T3b OH 2493 CMe NMe Q1b a bond Me abond NH S a bond T3c OH 2494 CMe NMe Q1b a bond Me a bond NH S a bondT3d OH 2495 CMe NMe Q1b a bond Me a bond NH S a bond T3e OH 2496 CMe NMeQ1b a bond Me a bond NH S a bond T3f OH 2497 CMe NMe Q1b a bond Me abond NH S a bond T3g OH 2498 CMe NMe Q1b a bond Me a bond NH S a bondT3h OH 2499 CMe NMe Q1b a bond Me a bond NH S a bond T3i OH 2500 CMe NMeQ1b a bond Me a bond NH S a bond T3j OH 2501 CMe NMe Q1b a bond Me abond NH O NH T3a OH 2502 CMe NMe Q1b a bond Me a bond NH O NH T3b OH2503 CMe NMe Q1b a bond Me a bond NH O NH T3c OH 2504 CMe NMe Q1b a bondMe a bond NH O NH T3d OH 2505 CMe NMe Q1b a bond Me a bond NH O NH T3eOH 2506 CMe NMe Q1b a bond Me a bond NH O NH T3f OH 2507 CMe NMe Q1b abond Me a bond NH O NH T3g OH 2508 CMe NMe Q1b a bond Me a bond NH O NHT3h OH 2509 CMe NMe Q1b a bond Me a bond NH O NH T3i OH 2510 CMe NMe Q1ba bond Me a bond NH O NH T3j OH 2511 CMe NMe Q1b a bond Me a bond NH O abond T3a OH 2512 CMe NMe Q1b a bond Me a bond NH O a bond T3b OH 2513CMe NMe Q1b a bond Me a bond NH O a bond T3c OH 2514 CMe NMe Q1b a bondMe a bond NH O a bond T3d OH 2515 CMe NMe Q1b a bond Me a bond NH O abond T3e OH 2516 CMe NMe Q1b a bond Me a bond NH O a bond T3f OH 2517CMe NMe Q1b a bond Me a bond NH O a bond T3g OH 2518 CMe NMe Q1b a bondMe a bond NH O a bond T3h OH 2519 CMe NMe Q1b a bond Me a bond NH O abond T3i OH 2520 CMe NMe Q1b a bond Me a bond NH O a bond T3j OH 2521CMe NMe Q1b a bond H a bond NH S NH T3a OH 2522 CMe NMe Q1b a bond H abond NH S NH T3b OH 2523 CMe NMe Q1b a bond H a bond NH S NH T3c OH 2524CMe NMe Q1b a bond H a bond NH S NH T3d OH 2525 CMe NMe Q1b a bond H abond NH S NH T3e OH 2526 CMe NMe Q1b a bond H a bond NH S NH T3f OH 2527CMe NMe Q1b a bond H a bond NH S NH T3g OH 2528 CMe NMe Q1b a bond H abond NH S NH T3h OH 2529 CMe NMe Q1b a bond H a bond NH S NH T3i OH 2530CMe NMe Q1b a bond H a bond NH S NH T3j OH 2531 CMe NMe Q1b a bond H abond NH S a bond T3a OH 2532 CMe NMe Q1b a bond H a bond NH S a bond T3bOH 2533 CMe NMe Q1b a bond H a bond NH S a bond T3c OH 2534 CMe NMe Q1ba bond H a bond NH S a bond T3d OH 2535 CMe NMe Q1b a bond H a bond NH Sa bond T3e OH 2536 CMe NMe Q1b a bond H a bond NH S a bond T3f OH 2537CMe NMe Q1b a bond H a bond NH S a bond T3g OH 2538 CMe NMe Q1b a bond Ha bond NH S a bond T3h OH 2539 CMe NMe Q1b a bond H a bond NH S a bondT3i OH 2540 CMe NMe Q1b a bond H a bond NH S a bond T3j OH 2541 CMe NMeQ1b a bond H a bond NH O NH T3a OH 2542 CMe NMe Q1b a bond H a bond NH ONH T3b OH 2543 CMe NMe Q1b a bond H a bond NH O NH T3c OH 2544 CMe NMeQ1b a bond H a bond NH O NH T3d OH 2545 CMe NMe Q1b a bond H a bond NH ONH T3e OH 2546 CMe NMe Q1b a bond H a bond NH O NH T3f OH 2547 CMe NMeQ1b a bond H a bond NH O NH T3g OH 2548 CMe NMe Q1b a bond H a bond NH ONH T3h OH 2549 CMe NMe Q1b a bond H a bond NH O NH T3i OH 2550 CMe NMeQ1b a bond H a bond NH O NH T3j OH 2551 CMe NMe Q1b a bond H a bond NH Oa bond T3a OH 2552 CMe NMe Q1b a bond H a bond NH O a bond T3b OH 2553CMe NMe Q1b a bond H a bond NH O a bond T3c OH 2554 CMe NMe Q1b a bond Ha bond NH O a bond T3d OH 2555 CMe NMe Q1b a bond H a bond NH O a bondT3e OH 2556 CMe NMe Q1b a bond H a bond NH O a bond T3f OH 2557 CMe NMeQ1b a bond H a bond NH O a bond T3g OH 2558 CMe NMe Q1b a bond H a bondNH O a bond T3h OH 2559 CMe NMe Q1b a bond H a bond NH O a bond T3i OH2560 CMe NMe Q1b a bond H a bond NH O a bond T3j OH 2561 CMe NMe Q1c abond Me a bond NH S NH T3a OH 2562 CMe NMe Q1c a bond Me a bond NH S NHT3b OH 2563 CMe NMe Q1c a bond Me a bond NH S NH T3c OH 2564 CMe NMe Q1ca bond Me a bond NH S NH T3d OH 2565 CMe NMe Q1c a bond Me a bond NH SNH T3e OH 2566 CMe NMe Q1c a bond Me a bond NH S NH T3f OH 2567 CMe NMeQ1c a bond Me a bond NH S NH T3g OH 2568 CMe NMe Q1c a bond Me a bond NHS NH T3h OH 2569 CMe NMe Q1c a bond Me a bond NH S NH T3i OH 2570 CMeNMe Q1c a bond Me a bond NH S NH T3j OH 2571 CMe NMe Q1c a bond Me abond NH S a bond T3a OH 2572 CMe NMe Q1c a bond Me a bond NH S a bondT3b OH 2573 CMe NMe Q1c a bond Me a bond NH S a bond T3c OH 2574 CMe NMeQ1c a bond Me a bond NH S a bond T3d OH 2575 CMe NMe Q1c a bond Me abond NH S a bond T3e OH 2576 CMe NMe Q1c a bond Me a bond NH S a bondT3f OH 2577 CMe NMe Q1c a bond Me a bond NH S a bond T3g OH 2578 CMe NMeQ1c a bond Me a bond NH S a bond T3h OH 2579 CMe NMe Q1c a bond Me abond NH S a bond T3i OH 2580 CMe NMe Q1c a bond Me a bond NH S a bondT3j OH 2581 CMe NMe Q1c a bond Me a bond NH O NH T3a OH 2582 CMe NMe Q1ca bond Me a bond NH O NH T3b OH 2583 CMe NMe Q1c a bond Me a bond NH ONH T3c OH 2584 CMe NMe Q1c a bond Me a bond NH O NH T3d OH 2585 CMe NMeQ1c a bond Me a bond NH O NH T3e OH 2586 CMe NMe Q1c a bond Me a bond NHO NH T3f OH 2587 CMe NMe Q1c a bond Me a bond NH O NH T3g OH 2588 CMeNMe Q1c a bond Me a bond NH O NH T3h OH 2589 CMe NMe Q1c a bond Me abond NH O NH T3i OH 2590 CMe NMe Q1c a bond Me a bond NH O NH T3j OH2591 CMe NMe Q1c a bond Me a bond NH O a bond T3a OH 2592 CMe NMe Q1c abond Me a bond NH O a bond T3b OH 2593 CMe NMe Q1c a bond Me a bond NH Oa bond T3c OH 2594 CMe NMe Q1c a bond Me a bond NH O a bond T3d OH 2595CMe NMe Q1c a bond Me a bond NH O a bond T3e OH 2596 CMe NMe Q1c a bondMe a bond NH O a bond T3f OH 2597 CMe NMe Q1c a bond Me a bond NH O abond T3g OH 2598 CMe NMe Q1c a bond Me a bond NH O a bond T3h OH 2599CMe NMe Q1c a bond Me a bond NH O a bond T3i OH 2600 CMe NMe Q1c a bondMe a bond NH O a bond T3j OH 2601 CMe NMe Q1c a bond H a bond NH S NHT3a OH 2602 CMe NMe Q1c a bond H a bond NH S NH T3b OH 2603 CMe NMe Q1ca bond H a bond NH S NH T3c OH 2604 CMe NMe Q1c a bond H a bond NH S NHT3d OH 2605 CMe NMe Q1c a bond H a bond NH S NH T3e OH 2606 CMe NMe Q1ca bond H a bond NH S NH T3f OH 2607 CMe NMe Q1c a bond H a bond NH S NHT3g OH 2608 CMe NMe Q1c a bond H a bond NH S NH T3h OH 2609 CMe NMe Q1ca bond H a bond NH S NH T3i OH 2610 CMe NMe Q1c a bond H a bond NH S NHT3j OH 2611 CMe NMe Q1c a bond H a bond NH S a bond T3a OH 2612 CMe NMeQ1c a bond H a bond NH S a bond T3b OH 2613 CMe NMe Q1c a bond H a bondNH S a bond T3c OH 2614 CMe NMe Q1c a bond H a bond NH S a bond T3d OH2615 CMe NMe Q1c a bond H a bond NH S a bond T3e OH 2616 CMe NMe Q1c abond H a bond NH S a bond T3f OH 2617 CMe NMe Q1c a bond H a bond NH S abond T3g OH 2618 CMe NMe Q1c a bond H a bond NH S a bond T3h OH 2619 CMeNMe Q1c a bond H a bond NH S a bond T3i OH 2620 CMe NMe Q1c a bond H abond NH S a bond T3j OH 2621 CMe NMe Q1c a bond H a bond NH O NH T3a OH2622 CMe NMe Q1c a bond H a bond NH O NH T3b OH 2623 CMe NMe Q1c a bondH a bond NH O NH T3c OH 2624 CMe NMe Q1c a bond H a bond NH O NH T3d OH2625 CMe NMe Q1c a bond H a bond NH O NH T3e OH 2626 CMe NMe Q1c a bondH a bond NH O NH T3f OH 2627 CMe NMe Q1c a bond H a bond NH O NH T3g OH2628 CMe NMe Q1c a bond H a bond NH O NH T3h OH 2629 CMe NMe Q1c a bondH a bond NH O NH T3i OH 2630 CMe NMe Q1c a bond H a bond NH O NH T3j OH2631 CMe NMe Q1c a bond H a bond NH O a bond T3a OH 2632 CMe NMe Q1c abond H a bond NH O a bond T3b OH 2633 CMe NMe Q1c a bond H a bond NH O abond T3c OH 2634 CMe NMe Q1c a bond H a bond NH O a bond T3d OH 2635 CMeNMe Q1c a bond H a bond NH O a bond T3e OH 2636 CMe NMe Q1c a bond H abond NH O a bond T3f OH 2637 CMe NMe Q1c a bond H a bond NH O a bond T3gOH 2638 CMe NMe Q1c a bond H a bond NH O a bond T3h OH 2639 CMe NMe Q1ca bond H a bond NH O a bond T3i OH 2640 CMe NMe Q1c a bond H a bond NH Oa bond T3j OH 2641 CMe NMe Q1i a bond Me a bond NH S NH T3a OH 2642 CMeNMe Q1i a bond Me a bond NH S NH T3b OH 2643 CMe NMe Q1i a bond Me abond NH S NH T3c OH 2644 CMe NMe Q1i a bond Me a bond NH S NH T3d OH2645 CMe NMe Q1i a bond Me a bond NH S NH T3e OH 2646 CMe NMe Q1i a bondMe a bond NH S NH T3f OH 2647 CMe NMe Q1i a bond Me a bond NH S NH T3gOH 2648 CMe NMe Q1i a bond Me a bond NH S NH T3h OH 2649 CMe NMe Q1i abond Me a bond NH S NH T3i OH 2650 CMe NMe Q1i a bond Me a bond NH S NHT3j OH 2651 CMe NMe Q1i a bond Me a bond NH S a bond T3a OH 2652 CMe NMeQ1i a bond Me a bond NH S a bond T3b OH 2653 CMe NMe Q1i a bond Me abond NH S a bond T3c OH 2654 CMe NMe Q1i a bond Me a bond NH S a bondT3d OH 2655 CMe NMe Q1i a bond Me a bond NH S a bond T3e OH 2656 CMe NMeQ1i a bond Me a bond NH S a bond T3f OH 2657 CMe NMe Q1i a bond Me abond NH S a bond T3g OH 2658 CMe NMe Q1i a bond Me a bond NH S a bondT3h OH 2659 CMe NMe Q1i a bond Me a bond NH S a bond T3i OH 2660 CMe NMeQ1i a bond Me a bond NH S a bond T3j OH 2661 CMe NMe Q1i a bond Me abond NH O NH T3a OH 2662 CMe NMe Q1i a bond Me a bond NH O NH T3b OH2663 CMe NMe Q1i a bond Me a bond NH O NH T3c OH 2664 CMe NMe Q1i a bondMe a bond NH O NH T3d OH 2665 CMe NMe Q1i a bond Me a bond NH O NH T3eOH 2666 CMe NMe Q1i a bond Me a bond NH O NH T3f OH 2667 CMe NMe Q1i abond Me a bond NH O NH T3g OH 2668 CMe NMe Q1i a bond Me a bond NH O NHT3h OH 2669 CMe NMe Q1i a bond Me a bond NH O NH T3i OH 2670 CMe NMe Q1ia bond Me a bond NH O NH T3j OH 2671 CMe NMe Q1i a bond Me a bond NH O abond T3a OH 2672 CMe NMe Q1i a bond Me a bond NH O a bond T3b OH 2673CMe NMe Q1i a bond Me a bond NH O a bond T3c OH 2674 CMe NMe Q1i a bondMe a bond NH O a bond T3d OH 2675 CMe NMe Q1i a bond Me a bond NH O abond T3e OH 2676 CMe NMe Q1i a bond Me a bond NH O a bond T3f OH 2677CMe NMe Q1i a bond Me a bond NH O a bond T3g OH 2678 CMe NMe Q1i a bondMe a bond NH O a bond T3h OH 2679 CMe NMe Q1i a bond Me a bond NH O abond T3i OH 2680 CMe NMe Q1i a bond Me a bond NH O a bond T3j OH 2681CMe NMe Q1i a bond H a bond NH S NH T3a OH 2682 CMe NMe Q1i a bond H abond NH S NH T3b OH 2683 CMe NMe Q1i a bond H a bond NH S NH T3c OH 2684CMe NMe Q1i a bond H a bond NH S NH T3d OH 2685 CMe NMe Q1i a bond H abond NH S NH T3e OH 2686 CMe NMe Q1i a bond H a bond NH S NH T3f OH 2687CMe NMe Q1i a bond H a bond NH S NH T3g OH 2688 CMe NMe Q1i a bond H abond NH S NH T3h OH 2689 CMe NMe Q1i a bond H a bond NH S NH T3i OH 2690CMe NMe Q1i a bond H a bond NH S NH T3j OH 2691 CMe NMe Q1i a bond H abond NH S a bond T3a OH 2692 CMe NMe Q1i a bond H a bond NH S a bond T3bOH 2693 CMe NMe Q1i a bond H a bond NH S a bond T3c OH 2694 CMe NMe Q1ia bond H a bond NH S a bond T3d OH 2695 CMe NMe Q1i a bond H a bond NH Sa bond T3e OH 2696 CMe NMe Q1i a bond H a bond NH S a bond T3f OH 2697CMe NMe Q1i a bond H a bond NH S a bond T3g OH 2698 CMe NMe Q1i a bond Ha bond NH S a bond T3h OH 2699 CMe NMe Q1i a bond H a bond NH S a bondT3i OH 2700 CMe NMe Q1i a bond H a bond NH S a bond T3j OH 2701 CMe NMeQ1i a bond H a bond NH O NH T3a OH 2702 CMe NMe Q1i a bond H a bond NH ONH T3b OH 2703 CMe NMe Q1i a bond H a bond NH O NH T3c OH 2704 CMe NMeQ1i a bond H a bond NH O NH T3d OH 2705 CMe NMe Q1i a bond H a bond NH ONH T3e OH 2706 CMe NMe Q1i a bond H a bond NH O NH T3f OH 2707 CMe NMeQ1i a bond H a bond NH O NH T3g OH 2708 CMe NMe Q1i a bond H a bond NH ONH T3h OH 2709 CMe NMe Q1i a bond H a bond NH O NH T3i OH 2710 CMe NMeQ1i a bond H a bond NH O NH T3j OH 2711 CMe NMe Q1i a bond H a bond NH Oa bond T3a OH 2712 CMe NMe Q1i a bond H a bond NH O a bond T3b OH 2713CMe NMe Q1i a bond H a bond NH O a bond T3c OH 2714 CMe NMe Q1i a bond Ha bond NH O a bond T3d OH 2715 CMe NMe Q1i a bond H a bond NH O a bondT3e OH 2716 CMe NMe Q1i a bond H a bond NH O a bond T3f OH 2717 CMe NMeQ1i a bond H a bond NH O a bond T3g OH 2718 CMe NMe Q1i a bond H a bondNH O a bond T3h OH 2719 CMe NMe Q1i a bond H a bond NH O a bond T3i OH2720 CMe NMe Q1i a bond H a bond NH O a bond T3j OH 2721 CMe NMe Q1j abond Me a bond NH S NH T3a OH 2722 CMe NMe Q1j a bond Me a bond NH S NHT3b OH 2723 CMe NMe Q1j a bond Me a bond NH S NH T3c OH 2724 CMe NMe Q1ja bond Me a bond NH S NH T3d OH 2725 CMe NMe Q1j a bond Me a bond NH SNH T3e OH 2726 CMe NMe Q1j a bond Me a bond NH S NH T3f OH 2727 CMe NMeQ1j a bond Me a bond NH S NH T3g OH 2728 CMe NMe Q1j a bond Me a bond NHS NH T3h OH 2729 CMe NMe Q1j a bond Me a bond NH S NH T3i OH 2730 CMeNMe Q1j a bond Me a bond NH S NH T3j OH 2731 CMe NMe Q1j a bond Me abond NH S a bond T3a OH 2732 CMe NMe Q1j a bond Me a bond NH S a bondT3b OH 2733 CMe NMe Q1j a bond Me a bond NH S a bond T3c OH 2734 CMe NMeQ1j a bond Me a bond NH S a bond T3d OH 2735 CMe NMe Q1j a bond Me abond NH S a bond T3e OH 2736 CMe NMe Q1j a bond Me a bond NH S a bondT3f OH 2737 CMe NMe Q1j a bond Me a bond NH S a bond T3g OH 2738 CMe NMeQ1j a bond Me a bond NH S a bond T3h OH 2739 CMe NMe Q1j a bond Me abond NH S a bond T3i OH 2740 CMe NMe Q1j a bond Me a bond NH S a bondT3j OH 2741 CMe NMe Q1j a bond Me a bond NH O NH T3a OH 2742 CMe NMe Q1ja bond Me a bond NH O NH T3b OH 2743 CMe NMe Q1j a bond Me a bond NH ONH T3c OH 2744 CMe NMe Q1j a bond Me a bond NH O NH T3d OH 2745 CMe NMeQ1j a bond Me a bond NH O NH T3e OH 2746 CMe NMe Q1j a bond Me a bond NHO NH T3f OH 2747 CMe NMe Q1j a bond Me a bond NH O NH T3g OH 2748 CMeNMe Q1j a bond Me a bond NH O NH T3h OH 2749 CMe NMe Q1j a bond Me abond NH O NH T3i OH 2750 CMe NMe Q1j a bond Me a bond NH O NH T3j OH2751 CMe NMe Q1j a bond Me a bond NH O a bond T3a OH 2752 CMe NMe Q1j abond Me a bond NH O a bond T3b OH 2753 CMe NMe Q1j a bond Me a bond NH Oa bond T3c OH 2754 CMe NMe Q1j a bond Me a bond NH O a bond T3d OH 2755CMe NMe Q1j a bond Me a bond NH O a bond T3e OH 2756 CMe NMe Q1j a bondMe a bond NH O a bond T3f OH 2757 CMe NMe Q1j a bond Me a bond NH O abond T3g OH 2758 CMe NMe Q1j a bond Me a bond NH O a bond T3h OH 2759CMe NMe Q1j a bond Me a bond NH O a bond T3i OH 2760 CMe NMe Q1j a bondMe a bond NH O a bond T3j OH 2761 CMe NMe Q1j a bond H a bond NH S NHT3a OH 2762 CMe NMe Q1j a bond H a bond NH S NH T3b OH 2763 CMe NMe Q1ja bond H a bond NH S NH T3c OH 2764 CMe NMe Q1j a bond H a bond NH S NHT3d OH 2765 CMe NMe Q1j a bond H a bond NH S NH T3e OH 2766 CMe NMe Q1ja bond H a bond NH S NH T3f OH 2767 CMe NMe Q1j a bond H a bond NH S NHT3g OH 2768 CMe NMe Q1j a bond H a bond NH S NH T3h OH 2769 CMe NMe Q1ja bond H a bond NH S NH T3i OH 2770 CMe NMe Q1j a bond H a bond NH S NHT3j OH 2771 CMe NMe Q1j a bond H a bond NH S a bond T3a OH 2772 CMe NMeQ1j a bond H a bond NH S a bond T3b OH 2773 CMe NMe Q1j a bond H a bondNH S a bond T3c OH 2774 CMe NMe Q1j a bond H a bond NH S a bond T3d OH2775 CMe NMe Q1j a bond H a bond NH S a bond T3e OH 2776 CMe NMe Q1j abond H a bond NH S a bond T3f OH 2777 CMe NMe Q1j a bond H a bond NH S abond T3g OH 2778 CMe NMe Q1j a bond H a bond NH S a bond T3h OH 2779 CMeNMe Q1j a bond H a bond NH S a bond T3i OH 2780 CMe NMe Q1j a bond H abond NH S a bond T3j OH 2781 CMe NMe Q1j a bond H a bond NH O NH T3a OH2782 CMe NMe Q1j a bond H a bond NH O NH T3b OH 2783 CMe NMe Q1j a bondH a bond NH O NH T3c OH 2784 CMe NMe Q1j a bond H a bond NH O NH T3d OH2785 CMe NMe Q1j a bond H a bond NH O NH T3e OH 2786 CMe NMe Q1j a bondH a bond NH O NH T3f OH 2787 CMe NMe Q1j a bond H a bond NH O NH T3g OH2788 CMe NMe Q1j a bond H a bond NH O NH T3h OH 2789 CMe NMe Q1j a bondH a bond NH O NH T3i OH 2790 CMe NMe Q1j a bond H a bond NH O NH T3j OH2791 CMe NMe Q1j a bond H a bond NH O a bond T3a OH 2792 CMe NMe Q1j abond H a bond NH O a bond T3b OH 2793 CMe NMe Q1j a bond H a bond NH O abond T3c OH 2794 CMe NMe Q1j a bond H a bond NH O a bond T3d OH 2795 CMeNMe Q1j a bond H a bond NH O a bond T3e OH 2796 CMe NMe Q1j a bond H abond NH O a bond T3f OH 2797 CMe NMe Q1j a bond H a bond NH O a bond T3gOH 2798 CMe NMe Q1j a bond H a bond NH O a bond T3h OH 2799 CMe NMe Q1ja bond H a bond NH O a bond T3i OH 2800 CMe NMe Q1j a bond H a bond NH Oa bond T3j OH 2801 CMe S Q1a a bond Me a bond NH S NH T3a OH 2802 CMe SQ1a a bond Me a bond NH S NH T3b OH 2803 CMe S Q1a a bond Me a bond NH SNH T3c OH 2804 CMe S Q1a a bond Me a bond NH S NH T3d OH 2805 CMe S Q1aa bond Me a bond NH S NH T3e OH 2806 CMe S Q1a a bond Me a bond NH S NHT3f OH 2807 CMe S Q1a a bond Me a bond NH S NH T3g OH 2808 CMe S Q1a abond Me a bond NH S NH T3h OH 2809 CMe S Q1a a bond Me a bond NH S NHT3i OH 2810 CMe S Q1a a bond Me a bond NH S NH T3j OH 2811 CMe S Q1a abond Me a bond NH S a bond T3a OH 2812 CMe S Q1a a bond Me a bond NH S abond T3b OH 2813 CMe S Q1a a bond Me a bond NH S a bond T3c OH 2814 CMeS Q1a a bond Me a bond NH S a bond T3d OH 2815 CMe S Q1a a bond Me abond NH S a bond T3e OH 2816 CMe S Q1a a bond Me a bond NH S a bond T3fOH 2817 CMe S Q1a a bond Me a bond NH S a bond T3g OH 2818 CMe S Q1a abond Me a bond NH S a bond T3h OH 2819 CMe S Q1a a bond Me a bond NH S abond T3i OH 2820 CMe S Q1a a bond Me a bond NH S a bond T3j OH 2821 CMeS Q1a a bond Me a bond NH O NH T3a OH 2822 CMe S Q1a a bond Me a bond NHO NH T3b OH 2823 CMe S Q1a a bond Me a bond NH O NH T3c OH 2824 CMe SQ1a a bond Me a bond NH O NH T3d OH 2825 CMe S Q1a a bond Me a bond NH ONH T3e OH 2826 CMe S Q1a a bond Me a bond NH O NH T3f OH 2827 CMe S Q1aa bond Me a bond NH O NH T3g OH 2828 CMe S Q1a a bond Me a bond NH O NHT3h OH 2829 CMe S Q1a a bond Me a bond NH O NH T3i OH 2830 CMe S Q1a abond Me a bond NH O NH T3j OH 2831 CMe S Q1a a bond Me a bond NH O abond T3a OH 2832 CMe S Q1a a bond Me a bond NH O a bond T3b OH 2833 CMeS Q1a a bond Me a bond NH O a bond T3c OH 2834 CMe S Q1a a bond Me abond NH O a bond T3d OH 2835 CMe S Q1a a bond Me a bond NH O a bond T3eOH 2836 CMe S Q1a a bond Me a bond NH O a bond T3f OH 2837 CMe S Q1a abond Me a bond NH O a bond T3g OH 2838 CMe S Q1a a bond Me a bond NH O abond T3h OH 2839 CMe S Q1a a bond Me a bond NH O a bond T3i OH 2840 CMeS Q1a a bond Me a bond NH O a bond T3j OH 2841 CMe S Q1a a bond H a bondNH S NH T3a OH 2842 CMe S Q1a a bond H a bond NH S NH T3b OH 2843 CMe SQ1a a bond H a bond NH S NH T3c OH 2844 CMe S Q1a a bond H a bond NH SNH T3d OH 2845 CMe S Q1a a bond H a bond NH S NH T3e OH 2846 CMe S Q1a abond H a bond NH S NH T3f OH 2847 CMe S Q1a a bond H a bond NH S NH T3gOH 2848 CMe S Q1a a bond H a bond NH S NH T3h OH 2849 CMe S Q1a a bond Ha bond NH S NH T3i OH 2850 CMe S Q1a a bond H a bond NH S NH T3j OH 2851CMe S Q1a a bond H a bond NH S a bond T3a OH 2852 CMe S Q1a a bond H abond NH S a bond T3b OH 2853 CMe S Q1a a bond H a bond NH S a bond T3cOH 2854 CMe S Q1a a bond H a bond NH S a bond T3d OH 2855 CMe S Q1a abond H a bond NH S a bond T3e OH 2856 CMe S Q1a a bond H a bond NH S abond T3f OH 2857 CMe S Q1a a bond H a bond NH S a bond T3g OH 2858 CMe SQ1a a bond H a bond NH S a bond T3h OH 2859 CMe S Q1a a bond H a bond NHS a bond T3i OH 2860 CMe S Q1a a bond H a bond NH S a bond T3j OH 2861CMe S Q1a a bond H a bond NH O NH T3a OH 2862 CMe S Q1a a bond H a bondNH O NH T3b OH 2863 CMe S Q1a a bond H a bond NH O NH T3c OH 2864 CMe SQ1a a bond H a bond NH O NH T3d OH 2865 CMe S Q1a a bond H a bond NH ONH T3e OH 2866 CMe S Q1a a bond H a bond NH O NH T3f OH 2867 CMe S Q1a abond H a bond NH O NH T3g OH 2868 CMe S Q1a a bond H a bond NH O NH T3hOH 2869 CMe S Q1a a bond H a bond NH O NH T3i OH 2870 CMe S Q1a a bond Ha bond NH O NH T3j OH 2871 CMe S Q1a a bond H a bond NH O a bond T3a OH2872 CMe S Q1a a bond H a bond NH O a bond T3b OH 2873 CMe S Q1a a bondH a bond NH O a bond T3c OH 2874 CMe S Q1a a bond H a bond NH O a bondT3d OH 2875 CMe S Q1a a bond H a bond NH O a bond T3e OH 2876 CMe S Q1aa bond H a bond NH O a bond T3f OH 2877 CMe S Q1a a bond H a bond NH O abond T3g OH 2878 CMe S Q1a a bond H a bond NH O a bond T3h OH 2879 CMe SQ1a a bond H a bond NH O a bond T3i OH 2880 CMe S Q1a a bond H a bond NHO a bond T3j OH 2881 CMe S Q1b a bond Me a bond NH S NH T3a OH 2882 CMeS Q1b a bond Me a bond NH S NH T3b OH 2883 CMe S Q1b a bond Me a bond NHS NH T3c OH 2884 CMe S Q1b a bond Me a bond NH S NH T3d OH 2885 CMe SQ1b a bond Me a bond NH S NH T3e OH 2886 CMe S Q1b a bond Me a bond NH SNH T3f OH 2887 CMe S Q1b a bond Me a bond NH S NH T3g OH 2888 CMe S Q1ba bond Me a bond NH S NH T3h OH 2889 CMe S Q1b a bond Me a bond NH S NHT3i OH 2890 CMe S Q1b a bond Me a bond NH S NH T3j OH 2891 CMe S Q1b abond Me a bond NH S a bond T3a OH 2892 CMe S Q1b a bond Me a bond NH S abond T3b OH 2893 CMe S Q1b a bond Me a bond NH S a bond T3c OH 2894 CMeS Q1b a bond Me a bond NH S a bond T3d OH 2895 CMe S Q1b a bond Me abond NH S a bond T3e OH 2896 CMe S Q1b a bond Me a bond NH S a bond T3fOH 2897 CMe S Q1b a bond Me a bond NH S a bond T3g OH 2898 CMe S Q1b abond Me a bond NH S a bond T3h OH 2899 CMe S Q1b a bond Me a bond NH S abond T3i OH 2900 CMe S Q1b a bond Me a bond NH S a bond T3j OH 2901 CMeS Q1b a bond Me a bond NH O NH T3a OH 2902 CMe S Q1b a bond Me a bond NHO NH T3b OH 2903 CMe S Q1b a bond Me a bond NH O NH T3c OH 2904 CMe SQ1b a bond Me a bond NH O NH T3d OH 2905 CMe S Q1b a bond Me a bond NH ONH T3e OH 2906 CMe S Q1b a bond Me a bond NH O NH T3f OH 2907 CMe S Q1ba bond Me a bond NH O NH T3g OH 2908 CMe S Q1b a bond Me a bond NH O NHT3h OH 2909 CMe S Q1b a bond Me a bond NH O NH T3i OH 2910 CMe S Q1b abond Me a bond NH O NH T3j OH 2911 CMe S Q1b a bond Me a bond NH O abond T3a OH 2912 CMe S Q1b a bond Me a bond NH O a bond T3b OH 2913 CMeS Q1b a bond Me a bond NH O a bond T3c OH 2914 CMe S Q1b a bond Me abond NH O a bond T3d OH 2915 CMe S Q1b a bond Me a bond NH O a bond T3eOH 2916 CMe S Q1b a bond Me a bond NH O a bond T3f OH 2917 CMe S Q1b abond Me a bond NH O a bond T3g OH 2918 CMe S Q1b a bond Me a bond NH O abond T3h OH 2919 CMe S Q1b a bond Me a bond NH O a bond T3i OH 2920 CMeS Q1b a bond Me a bond NH O a bond T3j OH 2921 CMe S Q1b a bond H a bondNH S NH T3a OH 2922 CMe S Q1b a bond H a bond NH S NH T3b OH 2923 CMe SQ1b a bond H a bond NH S NH T3c OH 2924 CMe S Q1b a bond H a bond NH SNH T3d OH 2925 CMe S Q1b a bond H a bond NH S NH T3e OH 2926 CMe S Q1b abond H a bond NH S NH T3f OH 2927 CMe S Q1b a bond H a bond NH S NH T3gOH 2928 CMe S Q1b a bond H a bond NH S NH T3h OH 2929 CMe S Q1b a bond Ha bond NH S NH T3i OH 2930 CMe S Q1b a bond H a bond NH S NH T3j OH 2931CMe S Q1b a bond H a bond NH S a bond T3a OH 2932 CMe S Q1b a bond H abond NH S a bond T3b OH 2933 CMe S Q1b a bond H a bond NH S a bond T3cOH 2934 CMe S Q1b a bond H a bond NH S a bond T3d OH 2935 CMe S Q1b abond H a bond NH S a bond T3e OH 2936 CMe S Q1b a bond H a bond NH S abond T3f OH 2937 CMe S Q1b a bond H a bond NH S a bond T3g OH 2938 CMe SQ1b a bond H a bond NH S a bond T3h OH 2939 CMe S Q1b a bond H a bond NHS a bond T3i OH 2940 CMe S Q1b a bond H a bond NH S a bond T3j OH 2941CMe S Q1b a bond H a bond NH O NH T3a OH 2942 CMe S Q1b a bond H a bondNH O NH T3b OH 2943 CMe S Q1b a bond H a bond NH O NH T3c OH 2944 CMe SQ1b a bond H a bond NH O NH T3d OH 2945 CMe S Q1b a bond H a bond NH ONH T3e OH 2946 CMe S Q1b a bond H a bond NH O NH T3f OH 2947 CMe S Q1b abond H a bond NH O NH T3g OH 2948 CMe S Q1b a bond H a bond NH O NH T3hOH 2949 CMe S Q1b a bond H a bond NH O NH T3i OH 2950 CMe S Q1b a bond Ha bond NH O NH T3j OH 2951 CMe S Q1b a bond H a bond NH O a bond T3a OH2952 CMe S Q1b a bond H a bond NH O a bond T3b OH 2953 CMe S Q1b a bondH a bond NH O a bond T3c OH 2954 CMe S Q1b a bond H a bond NH O a bondT3d OH 2955 CMe S Q1b a bond H a bond NH O a bond T3e OH 2956 CMe S Q1ba bond H a bond NH O a bond T3f OH 2957 CMe S Q1b a bond H a bond NH O abond T3g OH 2958 CMe S Q1b a bond H a bond NH O a bond T3h OH 2959 CMe SQ1b a bond H a bond NH O a bond T3i OH 2960 CMe S Q1b a bond H a bond NHO a bond T3j OH 2961 CMe S Q1c a bond Me a bond NH S NH T3a OH 2962 CMeS Q1c a bond Me a bond NH S NH T3b OH 2963 CMe S Q1c a bond Me a bond NHS NH T3c OH 2964 CMe S Q1c a bond Me a bond NH S NH T3d OH 2965 CMe SQ1c a bond Me a bond NH S NH T3e OH 2966 CMe S Q1c a bond Me a bond NH SNH T3f OH 2967 CMe S Q1c a bond Me a bond NH S NH T3g OH 2968 CMe S Q1ca bond Me a bond NH S NH T3h OH 2969 CMe S Q1c a bond Me a bond NH S NHT3i OH 2970 CMe S Q1c a bond Me a bond NH S NH T3j OH 2971 CMe S Q1c abond Me a bond NH S a bond T3a OH 2972 CMe S Q1c a bond Me a bond NH S abond T3b OH 2973 CMe S Q1c a bond Me a bond NH S a bond T3c OH 2974 CMeS Q1c a bond Me a bond NH S a bond T3d OH 2975 CMe S Q1c a bond Me abond NH S a bond T3e OH 2976 CMe S Q1c a bond Me a bond NH S a bond T3fOH 2977 CMe S Q1c a bond Me a bond NH S a bond T3g OH 2978 CMe S Q1c abond Me a bond NH S a bond T3h OH 2979 CMe S Q1c a bond Me a bond NH S abond T3i OH 2980 CMe S Q1c a bond Me a bond NH S a bond T3j OH 2981 CMeS Q1c a bond Me a bond NH O NH T3a OH 2982 CMe S Q1c a bond Me a bond NHO NH T3b OH 2983 CMe S Q1c a bond Me a bond NH O NH T3c OH 2984 CMe SQ1c a bond Me a bond NH O NH T3d OH 2985 CMe S Q1c a bond Me a bond NH ONH T3e OH 2986 CMe S Q1c a bond Me a bond NH O NH T3f OH 2987 CMe S Q1ca bond Me a bond NH O NH T3g OH 2988 CMe S Q1c a bond Me a bond NH O NHT3h OH 2989 CMe S Q1c a bond Me a bond NH O NH T3i OH 2990 CMe S Q1c abond Me a bond NH O NH T3j OH 2991 CMe S Q1c a bond Me a bond NH O abond T3a OH 2992 CMe S Q1c a bond Me a bond NH O a bond T3b OH 2993 CMeS Q1c a bond Me a bond NH O a bond T3c OH 2994 CMe S Q1c a bond Me abond NH O a bond T3d OH 2995 CMe S Q1c a bond Me a bond NH O a bond T3eOH 2996 CMe S Q1c a bond Me a bond NH O a bond T3f OH 2997 CMe S Q1c abond Me a bond NH O a bond T3g OH 2998 CMe S Q1c a bond Me a bond NH O abond T3h OH 2999 CMe S Q1c a bond Me a bond NH O a bond T3i OH 3000 CMeS Q1c a bond Me a bond NH O a bond T3j OH 3001 CMe S Q1c a bond H a bondNH S NH T3a OH 3002 CMe S Q1c a bond H a bond NH S NH T3b OH 3003 CMe SQ1c a bond H a bond NH S NH T3c OH 3004 CMe S Q1c a bond H a bond NH SNH T3d OH 3005 CMe S Q1c a bond H a bond NH S NH T3e OH 3006 CMe S Q1c abond H a bond NH S NH T3f OH 3007 CMe S Q1c a bond H a bond NH S NH T3gOH 3008 CMe S Q1c a bond H a bond NH S NH T3h OH 3009 CMe S Q1c a bond Ha bond NH S NH T3i OH 3010 CMe S Q1c a bond H a bond NH S NH T3i OH 3011CMe S Q1c a bond H a bond NH S a bond T3a OH 3012 CMe S Q1c a bond H abond NH S a bond T3b OH 3013 CMe S Q1c a bond H a bond NH S a bond T3cOH 3014 CMe S Q1c a bond H a bond NH S a bond T3d OH 3015 CMe S Q1c abond H a bond NH S a bond T3e OH 3016 CMe S Q1c a bond H a bond NH S abond T3f OH 3017 CMe S Q1c a bond H a bond NH S a bond T3g OH 3018 CMe SQ1c a bond H a bond NH S a bond T3h OH 3019 CMe S Q1c a bond H a bond NHS a bond T3i OH 3020 CMe S Q1c a bond H a bond NH S a bond T3j OH 3021CMe S Q1c a bond H a bond NH O NH T3a OH 3022 CMe S Q1c a bond H a bondNH O NH T3b OH 3023 CMe S Q1c a bond H a bond NH O NH T3c OH 3024 CMe SQ1c a bond H a bond NH O NH T3d OH 3025 CMe S Q1c a bond H a bond NH ONH T3e OH 3026 CMe S Q1c a bond H a bond NH O NH T3f OH 3027 CMe S Q1c abond H a bond NH O NH T3g OH 3028 CMe S Q1c a bond H a bond NH O NH T3hOH 3029 CMe S Q1c a bond H a bond NH O NH T3i OH 3030 CMe S Q1c a bond Ha bond NH O NH T3j OH 3031 CMe S Q1c a bond H a bond NH O a bond T3a OH3032 CMe S Q1c a bond H a bond NH O a bond T3b OH 3033 CMe S Q1c a bondH a bond NH O a bond T3c OH 3034 CMe S Q1c a bond H a bond NH O a bondT3d OH 3035 CMe S Q1c a bond H a bond NH O a bond T3e OH 3036 CMe S Q1ca bond H a bond NH O a bond T3f OH 3037 CMe S Q1c a bond H a bond NH O abond T3g OH 3038 CMe S Q1c a bond H a bond NH O a bond T3h OH 3039 CMe SQ1c a bond H a bond NH O a bond T3i OH 3040 CMe S Q1c a bond H a bond NHO a bond T3j OH 3041 CMe S Q1i a bond Me a bond NH S NH T3a OH 3042 CMeS Q1i a bond Me a bond NH S NH T3b OH 3043 CMe S Q1i a bond Me a bond NHS NH T3c OH 3044 CMe S Q1i a bond Me a bond NH S NH T3d OH 3045 CMe SQ1i a bond Me a bond NH S NH T3e OH 3046 CMe S Q1i a bond Me a bond NH SNH T3f OH 3047 CMe S Q1i a bond Me a bond NH S NH T3g OH 3048 CMe S Q1ia bond Me a bond NH S NH T3h OH 3049 CMe S Q1i a bond Me a bond NH S NHT3i OH 3050 CMe S Q1i a bond Me a bond NH S NH T3j OH 3051 CMe S Q1i abond Me a bond NH S a bond T3a OH 3052 CMe S Q1i a bond Me a bond NH S abond T3b OH 3053 CMe S Q1i a bond Me a bond NH S a bond T3c OH 3054 CMeS Q1i a bond Me a bond NH S a bond T3d OH 3055 CMe S Q1i a bond Me abond NH S a bond T3e OH 3056 CMe S Q1i a bond Me a bond NH S a bond T3fOH 3057 CMe S Q1i a bond Me a bond NH S a bond T3g OH 3058 CMe S Q1i abond Me a bond NH S a bond T3h OH 3059 CMe S Q1i a bond Me a bond NH S abond T3i OH 3060 CMe S Q1i a bond Me a bond NH S a bond T3j OH 3061 CMeS Q1i a bond Me a bond NH O NH T3a OH 3062 CMe S Q1i a bond Me a bond NHO NH T3b OH 3063 CMe S Q1i a bond Me a bond NH O NH T3c OH 3064 CMe SQ1i a bond Me a bond NH O NH T3d OH 3065 CMe S Q1i a bond Me a bond NH ONH T3e OH 3066 CMe S Q1i a bond Me a bond NH O NH T3f OH 3067 CMe S Q1ia bond Me a bond NH O NH T3g OH 3068 CMe S Q1i a bond Me a bond NH O NHT3h OH 3069 CMe S Q1i a bond Me a bond NH O NH T3i OH 3070 CMe S Q1i abond Me a bond NH O NH T3j OH 3071 CMe S Q1i a bond Me a bond NH O abond T3a OH 3072 CMe S Q1i a bond Me a bond NH O a bond T3b OH 3073 CMeS Q1i a bond Me a bond NH O a bond T3c OH 3074 CMe S Q1i a bond Me abond NH O a bond T3d OH 3075 CMe S Q1i a bond Me a bond NH O a bond T3eOH 3076 CMe S Q1i a bond Me a bond NH O a bond T3f OH 3077 CMe S Q1i abond Me a bond NH O a bond T3g OH 3078 CMe S Q1i a bond Me a bond NH O abond T3h OH 3079 CMe S Q1i a bond Me a bond NH O a bond T3i OH 3080 CMeS Q1i a bond Me a bond NH O a bond T3j OH 3081 CMe S Q1i a bond H a bondNH S NH T3a OH 3082 CMe S Q1i a bond H a bond NH S NH T3b OH 3083 CMe SQ1i a bond H a bond NH S NH T3c OH 3084 CMe S Q1i a bond H a bond NH SNH T3d OH 3085 CMe S Q1i a bond H a bond NH S NH T3e OH 3086 CMe S Q1i abond H a bond NH S NH T3f OH 3087 CMe S Q1i a bond H a bond NH S NH T3gOH 3088 CMe S Q1i a bond H a bond NH S NH T3h OH 3089 CMe S Q1i a bond Ha bond NH S NH T3i OH 3090 CMe S Q1i a bond H a bond NH S NH T3j OH 3091CMe S Q1i a bond H a bond NH S a bond T3a OH 3092 CMe S Q1i a bond H abond NH S a bond T3b OH 3093 CMe S Q1i a bond H a bond NH S a bond T3cOH 3094 CMe S Q1i a bond H a bond NH S a bond T3d OH 3095 CMe S Q1i abond H a bond NH S a bond T3e OH 3096 CMe S Q1i a bond H a bond NH S abond T3f OH 3097 CMe S Q1i a bond H a bond NH S a bond T3g OH 3098 CMe SQ1i a bond H a bond NH S a bond T3h OH 3099 CMe S Q1i a bond H a bond NHS a bond T3i OH 3100 CMe S Q1i a bond H a bond NH S a bond T3j OH 3101CMe S Q1i a bond H a bond NH O NH T3a OH 3102 CMe S Q1i a bond H a bondNH O NH T3b OH 3103 CMe S Q1i a bond H a bond NH O NH T3c OH 3104 CMe SQ1i a bond H a bond NH O NH T3d OH 3105 CMe S Q1i a bond H a bond NH ONH T3e OH 3106 CMe S Q1i a bond H a bond NH O NH T3f OH 3107 CMe S Q1i abond H a bond NH O NH T3g OH 3108 CMe S Q1i a bond H a bond NH O NH T3hOH 3109 CMe S Q1i a bond H a bond NH O NH T3i OH 3110 CMe S Q1i a bond Ha bond NH O NH T3j OH 3111 CMe S Q1i a bond H a bond NH O a bond T3a OH3112 CMe S Q1i a bond H a bond NH O a bond T3b OH 3113 CMe S Q1i a bondH a bond NH O a bond T3c OH 3114 CMe S Q1i a bond H a bond NH O a bondT3d OH 3115 CMe S Q1i a bond H a bond NH O a bond T3e OH 3116 CMe S Q1ia bond H a bond NH O a bond T3f OH 3117 CMe S Q1i a bond H a bond NH O abond T3g OH 3118 CMe S Q1i a bond H a bond NH O a bond T3h OH 3119 CMe SQ1i a bond H a bond NH O a bond T3i OH 3120 CMe S Q1i a bond H a bond NHO a bond T3j OH 3121 CMe S Q1j a bond Me a bond NH S NH T3a OH 3122 CMeS Q1j a bond Me a bond NH S NH T3b OH 3123 CMe S Q1j a bond Me a bond NHS NH T3c OH 3124 CMe S Q1j a bond Me a bond NH S NH T3d OH 3125 CMe SQ1j a bond Me a bond NH S NH T3e OH 3126 CMe S Q1j a bond Me a bond NH SNH T3f OH 3127 CMe S Q1j a bond Me a bond NH S NH T3g OH 3128 CMe S Q1ja bond Me a bond NH S NH T3h OH 3129 CMe S Q1j a bond Me a bond NH S NHT3i OH 3130 CMe S Q1j a bond Me a bond NH S NH T3j OH 3131 CMe S Q1j abond Me a bond NH S a bond T3a OH 3132 CMe S Q1j a bond Me a bond NH S abond T3b OH 3133 CMe S Q1j a bond Me a bond NH S a bond T3c OH 3134 CMeS Q1j a bond Me a bond NH S a bond T3d OH 3135 CMe S Q1j a bond Me abond NH S a bond T3e OH 3136 CMe S Q1j a bond Me a bond NH S a bond T3fOH 3137 CMe S Q1j a bond Me a bond NH S a bond T3g OH 3138 CMe S Q1j abond Me a bond NH S a bond T3h OH 3139 CMe S Q1j a bond Me a bond NH S abond T3i OH 3140 CMe S Q1j a bond Me a bond NH S a bond T3j OH 3141 CMeS Q1j a bond Me a bond NH O NH T3a OH 3142 CMe S Q1j a bond Me a bond NHO NH T3b OH 3143 CMe S Q1j a bond Me a bond NH O NH T3c OH 3144 CMe SQ1j a bond Me a bond NH O NH T3d OH 3145 CMe S Q1j a bond Me a bond NH ONH T3e OH 3146 CMe S Q1j a bond Me a bond NH O NH T3f OH 3147 CMe S Q1ja bond Me a bond NH O NH T3g OH 3148 CMe S Q1j a bond Me a bond NH O NHT3h OH 3149 CMe S Q1j a bond Me a bond NH O NH T3i OH 3150 CMe S Q1j abond Me a bond NH O NH T3j OH 3151 CMe S Q1j a bond Me a bond NH O abond T3a OH 3152 CMe S Q1j a bond Me a bond NH O a bond T3b OH 3153 CMeS Q1j a bond Me a bond NH O a bond T3c OH 3154 CMe S Q1j a bond Me abond NH O a bond T3d OH 3155 CMe S Q1j a bond Me a bond NH O a bond T3eOH 3156 CMe S Q1j a bond Me a bond NH O a bond T3f OH 3157 CMe S Q1j abond Me a bond NH O a bond T3g OH 3158 CMe S Q1j a bond Me a bond NH O abond T3h OH 3159 CMe S Q1j a bond Me a bond NH O a bond T3i OH 3160 CMeS Q1j a bond Me a bond NH O a bond T3j OH 3161 CMe S Q1j a bond H a bondNH S NH T3a OH 3162 CMe S Q1j a bond H a bond NH S NH T3b OH 3163 CMe SQ1j a bond H a bond NH S NH T3c OH 3164 CMe S Q1j a bond H a bond NH SNH T3d OH 3165 CMe S Q1j a bond H a bond NH S NH T3e OH 3166 CMe S Q1j abond H a bond NH S NH T3f OH 3167 CMe S Q1j a bond H a bond NH S NH T3gOH 3168 CMe S Q1j a bond H a bond NH S NH T3h OH 3169 CMe S Q1j a bond Ha bond NH S NH T3i OH 3170 CMe S Q1j a bond H a bond NH S NH T3j OH 3171CMe S Q1j a bond H a bond NH S a bond T3a OH 3172 CMe S Q1j a bond H abond NH S a bond T3b OH 3173 CMe S Q1j a bond H a bond NH S a bond T3cOH 3174 CMe S Q1j a bond H a bond NH S a bond T3d OH 3175 CMe S Q1j abond H a bond NH S a bond T3e OH 3176 CMe S Q1j a bond H a bond NH S abond T3f OH 3177 CMe S Q1j a bond H a bond NH S a bond T3g OH 3178 CMe SQ1j a bond H a bond NH S a bond T3h OH 3179 CMe S Q1j a bond H a bond NHS a bond T3i OH 3180 CMe S Q1j a bond H a bond NH S a bond T3j OH 3181CMe S Q1j a bond H a bond NH O NH T3a OH 3182 CMe S Q1j a bond H a bondNH O NH T3b OH 3183 CMe S Q1j a bond H a bond NH O NH T3c OH 3184 CMe SQ1j a bond H a bond NH O NH T3d OH 3185 CMe S Q1j a bond H a bond NH ONH T3e OH 3186 CMe S Q1j a bond H a bond NH O NH T3f OH 3187 CMe S Q1j abond H a bond NH O NH T3g OH 3188 CMe S Q1j a bond H a bond NH O NH T3hOH 3189 CMe S Q1j a bond H a bond NH O NH T3i OH 3190 CMe S Q1j a bond Ha bond NH O NH T3j OH 3191 CMe S Q1j a bond H a bond NH O a bond T3a OH3192 CMe S Q1j a bond H a bond NH O a bond T3b OH 3193 CMe S Q1j a bondH a bond NH O a bond T3c OH 3194 CMe S Q1j a bond H a bond NH O a bondT3d OH 3195 CMe S Q1j a bond H a bond NH O a bond T3e OH 3196 CMe S Q1ja bond H a bond NH O a bond T3f OH 3197 CMe S Q1j a bond H a bond NH O abond T3g OH 3198 CMe S Q1j a bond H a bond NH O a bond T3h OH 3199 CMe SQ1j a bond H a bond NH O a bond T3i OH 3200 CMe S Q1j a bond H a bond NHO a bond T3j OH 3201 CMe O Q1a a bond Me a bond NH S NH T3a OH 3202 CMeO Q1a a bond Me a bond NH S NH T3b OH 3203 CMe O Q1a a bond Me a bond NHS NH T3c OH 3204 CMe O Q1a a bond Me a bond NH S NH T3d OH 3205 CMe OQ1a a bond Me a bond NH S NH T3e OH 3206 CMe O Q1a a bond Me a bond NH SNH T3f OH 3207 CMe O Q1a a bond Me a bond NH S NH T3g OH 3208 CMe O Q1aa bond Me a bond NH S NH T3h OH 3209 CMe O Q1a a bond Me a bond NH S NHT3i OH 3210 CMe O Q1a a bond Me a bond NH S NH T3j OH 3211 CMe O Q1a abond Me a bond NH S a bond T3a OH 3212 CMe O Q1a a bond Me a bond NH S abond T3b OH 3213 CMe O Q1a a bond Me a bond NH S a bond T3c OH 3214 CMeO Q1a a bond Me a bond NH S a bond T3d OH 3215 CMe O Q1a a bond Me abond NH S a bond T3e OH 3216 CMe O Q1a a bond Me a bond NH S a bond T3fOH 3217 CMe O Q1a a bond Me a bond NH S a bond T3g OH 3218 CMe O Q1a abond Me a bond NH S a bond T3h OH 3219 CMe O Q1a a bond Me a bond NH S abond T3i OH 3220 CMe O Q1a a bond Me a bond NH S a bond T3j OH 3221 CMeO Q1a a bond Me a bond NH O NH T3a OH 3222 CMe O Q1a a bond Me a bond NHO NH T3b OH 3223 CMe O Q1a a bond Me a bond NH O NH T3c OH 3224 CMe OQ1a a bond Me a bond NH O NH T3d OH 3225 CMe O Q1a a bond Me a bond NH ONH T3e OH 3226 CMe O Q1a a bond Me a bond NH O NH T3f OH 3227 CMe O Q1aa bond Me a bond NH O NH T3g OH 3228 CMe O Q1a a bond Me a bond NH O NHT3h OH 3229 CMe O Q1a a bond Me a bond NH O NH T3i OH 3230 CMe O Q1a abond Me a bond NH O NH T3j OH 3231 CMe O Q1a a bond Me a bond NH O abond T3a OH 3232 CMe O Q1a a bond Me a bond NH O a bond T3b OH 3233 CMeO Q1a a bond Me a bond NH O a bond T3c OH 3234 CMe O Q1a a bond Me abond NH O a bond T3d OH 3235 CMe O Q1a a bond Me a bond NH O a bond T3eOH 3236 CMe O Q1a a bond Me a bond NH O a bond T3f OH 3237 CMe O Q1a abond Me a bond NH O a bond T3g OH 3238 CMe O Q1a a bond Me a bond NH O abond T3h OH 3239 CMe O Q1a a bond Me a bond NH O a bond T3i OH 3240 CMeO Q1a a bond Me a bond NH O a bond T3j OH 3241 CMe O Q1a a bond H a bondNH S NH T3a OH 3242 CMe O Q1a a bond H a bond NH S NH T3b OH 3243 CMe OQ1a a bond H a bond NH S NH T3c OH 3244 CMe O Q1a a bond H a bond NH SNH T3d OH 3245 CMe O Q1a a bond H a bond NH S NH T3e OH 3246 CMe O Q1a abond H a bond NH S NH T3f OH 3247 CMe O Q1a a bond H a bond NH S NH T3gOH 3248 CMe O Q1a a bond H a bond NH S NH T3h OH 3249 CMe O Q1a a bond Ha bond NH S NH T3i OH 3250 CMe O Q1a a bond H a bond NH S NH T3j OH 3251CMe O Q1a a bond H a bond NH S a bond T3a OH 3252 CMe O Q1a a bond H abond NH S a bond T3b OH 3253 CMe O Q1a a bond H a bond NH S a bond T3cOH 3254 CMe O Q1a a bond H a bond NH S a bond T3d OH 3255 CMe O Q1a abond H a bond NH S a bond T3e OH 3256 CMe O Q1a a bond H a bond NH S abond T3f OH 3257 CMe O Q1a a bond H a bond NH S a bond T3g OH 3258 CMe OQ1a a bond H a bond NH S a bond T3h OH 3259 CMe O Q1a a bond H a bond NHS a bond T3i OH 3260 CMe O Q1a a bond H a bond NH S a bond T3j OH 3261CMe O Q1a a bond H a bond NH O NH T3a OH 3262 CMe O Q1a a bond H a bondNH O NH T3b OH 3263 CMe O Q1a a bond H a bond NH O NH T3c OH 3264 CMe OQ1a a bond H a bond NH O NH T3d OH 3265 CMe O Q1a a bond H a bond NH ONH T3e OH 3266 CMe O Q1a a bond H a bond NH O NH T3f OH 3267 CMe O Q1a abond H a bond NH O NH T3g OH 3268 CMe O Q1a a bond H a bond NH O NH T3hOH 3269 CMe O Q1a a bond H a bond NH O NH T3i OH 3270 CMe O Q1a a bond Ha bond NH O NH T3j OH 3271 CMe O Q1a a bond H a bond NH O a bond T3a OH3272 CMe O Q1a a bond H a bond NH O a bond T3b OH 3273 CMe O Q1a a bondH a bond NH O a bond T3c OH 3274 CMe O Q1a a bond H a bond NH O a bondT3d OH 3275 CMe O Q1a a bond H a bond NH O a bond T3e OH 3276 CMe O Q1aa bond H a bond NH O a bond T3f OH 3277 CMe O Q1a a bond H a bond NH O abond T3g OH 3278 CMe O Q1a a bond H a bond NH O a bond T3h OH 3279 CMe OQ1a a bond H a bond NH O a bond T3i OH 3280 CMe O Q1a a bond H a bond NHO a bond T3j OH 3281 CMe O Q1b a bond Me a bond NH S NH T3a OH 3282 CMeO Q1b a bond Me a bond NH S NH T3b OH 3283 CMe O Q1b a bond Me a bond NHS NH T3c OH 3284 CMe O Q1b a bond Me a bond NH S NH T3d OH 3285 CMe OQ1b a bond Me a bond NH S NH T3e OH 3286 CMe O Q1b a bond Me a bond NH SNH T3f OH 3287 CMe O Q1b a bond Me a bond NH S NH T3g OH 3288 CMe O Q1ba bond Me a bond NH S NH T3h OH 3289 CMe O Q1b a bond Me a bond NH S NHT3i OH 3290 CMe O Q1b a bond Me a bond NH S NH T3j OH 3291 CMe O Q1b abond Me a bond NH S a bond T3a OH 3292 CMe O Q1b a bond Me a bond NH S abond T3b OH 3293 CMe O Q1b a bond Me a bond NH S a bond T3c OH 3294 CMeO Q1b a bond Me a bond NH S a bond T3d OH 3295 CMe O Q1b a bond Me abond NH S a bond T3e OH 3296 CMe O Q1b a bond Me a bond NH S a bond T3fOH 3297 CMe O Q1b a bond Me a bond NH S a bond T3g OH 3298 CMe O Q1b abond Me a bond NH S a bond T3h OH 3299 CMe O Q1b a bond Me a bond NH S abond T3i OH 3300 CMe O Q1b a bond Me a bond NH S a bond T3j OH 3301 CMeO Q1b a bond Me a bond NH O NH T3a OH 3302 CMe O Q1b a bond Me a bond NHO NH T3b OH 3303 CMe O Q1b a bond Me a bond NH O NH T3c OH 3304 CMe OQ1b a bond Me a bond NH O NH T3d OH 3305 CMe O Q1b a bond Me a bond NH ONH T3e OH 3306 CMe O Q1b a bond Me a bond NH O NH T3f OH 3307 CMe O Q1ba bond Me a bond NH O NH T3g OH 3308 CMe O Q1b a bond Me a bond NH O NHT3h OH 3309 CMe O Q1b a bond Me a bond NH O NH T3i OH 3310 CMe O Q1b abond Me a bond NH O NH T3j OH 3311 CMe O Q1b a bond Me a bond NH O abond T3a OH 3312 CMe O Q1b a bond Me a bond NH O a bond T3b OH 3313 CMeO Q1b a bond Me a bond NH O a bond T3c OH 3314 CMe O Q1b a bond Me abond NH O a bond T3d OH 3315 CMe O Q1b a bond Me a bond NH O a bond T3eOH 3316 CMe O Q1b a bond Me a bond NH O a bond T3f OH 3317 CMe O Q1b abond Me a bond NH O a bond T3g OH 3318 CMe O Q1b a bond Me a bond NH O abond T3h OH 3319 CMe O Q1b a bond Me a bond NH O a bond T3i OH 3320 CMeO Q1b a bond Me a bond NH O a bond T3j OH 3321 CMe O Q1b a bond H a bondNH S NH T3a OH 3322 CMe O Q1b a bond H a bond NH S NH T3b OH 3323 CMe OQ1b a bond H a bond NH S NH T3c OH 3324 CMe O Q1b a bond H a bond NH SNH T3d OH 3325 CMe O Q1b a bond H a bond NH S NH T3e OH 3326 CMe O Q1b abond H a bond NH S NH T3f OH 3327 CMe O Q1b a bond H a bond NH S NH T3gOH 3328 CMe O Q1b a bond H a bond NH S NH T3h OH 3329 CMe O Q1b a bond Ha bond NH S NH T3i OH 3330 CMe O Q1b a bond H a bond NH S NH T3j OH 3331CMe O Q1b a bond H a bond NH S a bond T3a OH 3332 CMe O Q1b a bond H abond NH S a bond T3b OH 3333 CMe O Q1b a bond H a bond NH S a bond T3cOH 3334 CMe O Q1b a bond H a bond NH S a bond T3d OH 3335 CMe O Q1b abond H a bond NH S a bond T3e OH 3336 CMe O Q1b a bond H a bond NH S abond T3f OH 3337 CMe O Q1b a bond H a bond NH S a bond T3g OH 3338 CMe OQ1b a bond H a bond NH S a bond T3h OH 3339 CMe O Q1b a bond H a bond NHS a bond T3i OH 3340 CMe O Q1b a bond H a bond NH S a bond T3j OH 3341CMe O Q1b a bond H a bond NH O NH T3a OH 3342 CMe O Q1b a bond H a bondNH O NH T3b OH 3343 CMe O Q1b a bond H a bond NH O NH T3c OH 3344 CMe OQ1b a bond H a bond NH O NH T3d OH 3345 CMe O Q1b a bond H a bond NH ONH T3e OH 3346 CMe O Q1b a bond H a bond NH O NH T3f OH 3347 CMe O Q1b abond H a bond NH O NH T3g OH 3348 CMe O Q1b a bond H a bond NH O NH T3hOH 3349 CMe O Q1b a bond H a bond NH O NH T3i OH 3350 CMe O Q1b a bond Ha bond NH O NH T3j OH 3351 CMe O Q1b a bond H a bond NH O a bond T3a OH3352 CMe O Q1b a bond H a bond NH O a bond T3b OH 3353 CMe O Q1b a bondH a bond NH O a bond T3c OH 3354 CMe O Q1b a bond H a bond NH O a bondT3d OH 3355 CMe O Q1b a bond H a bond NH O a bond T3e OH 3356 CMe O Q1ba bond H a bond NH O a bond T3f OH 3357 CMe O Q1b a bond H a bond NH O abond T3g OH 3358 CMe O Q1b a bond H a bond NH O a bond T3h OH 3359 CMe OQ1b a bond H a bond NH O a bond T3i OH 3360 CMe O Q1b a bond H a bond NHO a bond T3j OH 3361 CMe O Q1c a bond Me a bond NH S NH T3a OH 3362 CMeO Q1c a bond Me a bond NH S NH T3b OH 3363 CMe O Q1c a bond Me a bond NHS NH T3c OH 3364 CMe O Q1c a bond Me a bond NH S NH T3d OH 3365 CMe OQ1c a bond Me a bond NH S NH T3e OH 3366 CMe O Q1c a bond Me a bond NH SNH T3f OH 3367 CMe O Q1c a bond Me a bond NH S NH T3g OH 3368 CMe O Q1ca bond Me a bond NH S NH T3h OH 3369 CMe O Q1c a bond Me a bond NH S NHT3i OH 3370 CMe O Q1c a bond Me a bond NH S NH T3j OH 3371 CMe O Q1c abond Me a bond NH S a bond T3a OH 3372 CMe O Q1c a bond Me a bond NH S abond T3b OH 3373 CMe O Q1c a bond Me a bond NH S a bond T3c OH 3374 CMeO Q1c a bond Me a bond NH S a bond T3d OH 3375 CMe O Q1c a bond Me abond NH S a bond T3e OH 3376 CMe O Q1c a bond Me a bond NH S a bond T3fOH 3377 CMe O Q1c a bond Me a bond NH S a bond T3g OH 3378 CMe O Q1c abond Me a bond NH S a bond T3h OH 3379 CMe O Q1c a bond Me a bond NH S abond T3i OH 3380 CMe O Q1c a bond Me a bond NH S a bond T3j OH 3381 CMeO Q1c a bond Me a bond NH O NH T3a OH 3382 CMe O Q1c a bond Me a bond NHO NH T3b OH 3383 CMe O Q1c a bond Me a bond NH O NH T3c OH 3384 CMe OQ1c a bond Me a bond NH O NH T3d OH 3385 CMe O Q1c a bond Me a bond NH ONH T3e OH 3386 CMe O Q1c a bond Me a bond NH O NH T3f OH 3387 CMe O Q1ca bond Me a bond NH O NH T3g OH 3388 CMe O Q1c a bond Me a bond NH O NHT3h OH 3389 CMe O Q1c a bond Me a bond NH O NH T3i OH 3390 CMe O Q1c abond Me a bond NH O NH T3j OH 3391 CMe O Q1c a bond Me a bond NH O abond T3a OH 3392 CMe O Q1c a bond Me a bond NH O a bond T3b OH 3393 CMeO Q1c a bond Me a bond NH O a bond T3c OH 3394 CMe O Q1c a bond Me abond NH O a bond T3d OH 3395 CMe O Q1c a bond Me a bond NH O a bond T3eOH 3396 CMe O Q1c a bond Me a bond NH O a bond T3f OH 3397 CMe O Q1c abond Me a bond NH O a bond T3g OH 3398 CMe O Q1c a bond Me a bond NH O abond T3h OH 3399 CMe O Q1c a bond Me a bond NH O a bond T3i OH 3400 CMeO Q1c a bond Me a bond NH O a bond T3j OH 3401 CMe O Q1c a bond H a bondNH S NH T3a OH 3402 CMe O Q1c a bond H a bond NH S NH T3b OH 3403 CMe OQ1c a bond H a bond NH S NH T3c OH 3404 CMe O Q1c a bond H a bond NH SNH T3d OH 3405 CMe O Q1c a bond H a bond NH S NH T3e OH 3406 CMe O Q1c abond H a bond NH S NH T3f OH 3407 CMe O Q1c a bond H a bond NH S NH T3gOH 3408 CMe O Q1c a bond H a bond NH S NH T3h OH 3409 CMe O Q1c a bond Ha bond NH S NH T3i OH 3410 CMe O Q1c a bond H a bond NH S NH T3j OH 3411CMe O Q1c a bond H a bond NH S a bond T3a OH 3412 CMe O Q1c a bond H abond NH S a bond T3b OH 3413 CMe O Q1c a bond H a bond NH S a bond T3cOH 3414 CMe O Q1c a bond H a bond NH S a bond T3d OH 3415 CMe O Q1c abond H a bond NH S a bond T3e OH 3416 CMe O Q1c a bond H a bond NH S abond T3f OH 3417 CMe O Q1c a bond H a bond NH S a bond T3g OH 3418 CMe OQ1c a bond H a bond NH S a bond T3h OH 3419 CMe O Q1c a bond H a bond NHS a bond T3i OH 3420 CMe O Q1c a bond H a bond NH S a bond T3j OH 3421CMe O Q1c a bond H a bond NH O NH T3a OH 3422 CMe O Q1c a bond H a bondNH O NH T3b OH 3423 CMe O Q1c a bond H a bond NH O NH T3c OH 3424 CMe OQ1c a bond H a bond NH O NH T3d OH 3425 CMe O Q1c a bond H a bond NH ONH T3e OH 3426 CMe O Q1c a bond H a bond NH O NH T3f OH 3427 CMe O Q1c abond H a bond NH O NH T3g OH 3428 CMe O Q1c a bond H a bond NH O NH T3hOH 3429 CMe O Q1c a bond H a bond NH O NH T3i OH 3430 CMe O Q1c a bond Ha bond NH O NH T3j OH 3431 CMe O Q1c a bond H a bond NH O a bond T3a OH3432 CMe O Q1c a bond H a bond NH O a bond T3b OH 3433 CMe O Q1c a bondH a bond NH O a bond T3c OH 3434 CMe O Q1c a bond H a bond NH O a bondT3d OH 3435 CMe O Q1c a bond H a bond NH O a bond T3e OH 3436 CMe O Q1ca bond H a bond NH O a bond T3f OH 3437 CMe O Q1c a bond H a bond NH O abond T3g OH 3438 CMe O Q1c a bond H a bond NH O a bond T3h OH 3439 CMe OQ1c a bond H a bond NH O a bond T3i OH 3440 CMe O Q1c a bond H a bond NHO a bond T3j OH 3441 CMe O Q1i a bond Me a bond NH S NH T3a OH 3442 CMeO Q1i a bond Me a bond NH S NH T3b OH 3443 CMe O Q1i a bond Me a bond NHS NH T3c OH 3444 CMe O Q1i a bond Me a bond NH S NH T3d OH 3445 CMe OQ1i a bond Me a bond NH S NH T3e OH 3446 CMe O Q1i a bond Me a bond NH SNH T3f OH 3447 CMe O Q1i a bond Me a bond NH S NH T3g OH 3448 CMe O Q1ia bond Me a bond NH S NH T3h OH 3449 CMe O Q1i a bond Me a bond NH S NHT3i OH 3450 CMe O Q1i a bond Me a bond NH S NH T3j OH 3451 CMe O Q1i abond Me a bond NH S a bond T3a OH 3452 CMe O Q1i a bond Me a bond NH S abond T3b OH 3453 CMe O Q1i a bond Me a bond NH S a bond T3c OH 3454 CMeO Q1i a bond Me a bond NH S a bond T3d OH 3455 CMe O Q1i a bond Me abond NH S a bond T3e OH 3456 CMe O Q1i a bond Me a bond NH S a bond T3fOH 3457 CMe O Q1i a bond Me a bond NH S a bond T3g OH 3458 CMe O Q1i abond Me a bond NH S a bond T3h OH 3459 CMe O Q1i a bond Me a bond NH S abond T3i OH 3460 CMe O Q1i a bond Me a bond NH S a bond T3j OH 3461 CMeO Q1i a bond Me a bond NH O NH T3a OH 3462 CMe O Q1i a bond Me a bond NHO NH T3b OH 3463 CMe O Q1i a bond Me a bond NH O NH T3c OH 3464 CMe OQ1i a bond Me a bond NH O NH T3d OH 3465 CMe O Q1i a bond Me a bond NH ONH T3e OH 3466 CMe O Q1i a bond Me a bond NH O NH T3f OH 3467 CMe O Q1ia bond Me a bond NH O NH T3g OH 3468 CMe O Q1i a bond Me a bond NH O NHT3h OH 3469 CMe O Q1i a bond Me a bond NH O NH T3i OH 3470 CMe O Q1i abond Me a bond NH O NH T3j OH 3471 CMe O Q1i a bond Me a bond NH O abond T3a OH 3472 CMe O Q1i a bond Me a bond NH O a bond T3b OH 3473 CMeO Q1i a bond Me a bond NH O a bond T3c OH 3474 CMe O Q1i a bond Me abond NH O a bond T3d OH 3475 CMe O Q1i a bond Me a bond NH O a bond T3eOH 3476 CMe O Q1i a bond Me a bond NH O a bond T3f OH 3477 CMe O Q1i abond Me a bond NH O a bond T3g OH 3478 CMe O Q1i a bond Me a bond NH O abond T3h OH 3479 CMe O Q1i a bond Me a bond NH O a bond T3i OH 3480 CMeO Q1i a bond Me a bond NH O a bond T3j OH 3481 CMe O Q1i a bond H a bondNH S NH T3a OH 3482 CMe O Q1i a bond H a bond NH S NH T3b OH 3483 CMe OQ1i a bond H a bond NH S NH T3c OH 3484 CMe O Q1i a bond H a bond NH SNH T3d OH 3485 CMe O Q1i a bond H a bond NH S NH T3e OH 3486 CMe O Q1i abond H a bond NH S NH T3f OH 3487 CMe O Q1i a bond H a bond NH S NH T3gOH 3488 CMe O Q1i a bond H a bond NH S NH T3h OH 3489 CMe O Q1i a bond Ha bond NH S NH T3i OH 3490 CMe O Q1i a bond H a bond NH S NH T3j OH 3491CMe O Q1i a bond H a bond NH S a bond T3a OH 3492 CMe O Q1i a bond H abond NH S a bond T3b OH 3493 CMe O Q1i a bond H a bond NH S a bond T3cOH 3494 CMe O Q1i a bond H a bond NH S a bond T3d OH 3495 CMe O Q1i abond H a bond NH S a bond T3e OH 3496 CMe O Q1i a bond H a bond NH S abond T3f OH 3497 CMe O Q1i a bond H a bond NH S a bond T3g OH 3498 CMe OQ1i a bond H a bond NH S a bond T3h OH 3499 CMe O Q1i a bond H a bond NHS a bond T3i OH 3500 CMe O Q1i a bond H a bond NH S a bond T3j OH 3501CMe O Q1i a bond H a bond NH O NH T3a OH 3502 CMe O Q1i a bond H a bondNH O NH T3b OH 3503 CMe O Q1i a bond H a bond NH O NH T3c OH 3504 CMe OQ1i a bond H a bond NH O NH T3d OH 3505 CMe O Q1i a bond H a bond NH ONH T3e OH 3506 CMe O Q1i a bond H a bond NH O NH T3f OH 3507 CMe O Q1i abond H a bond NH O NH T3g OH 3508 CMe O Q1i a bond H a bond NH O NH T3hOH 3509 CMe O Q1i a bond H a bond NH O NH T3i OH 3510 CMe O Q1i a bond Ha bond NH O NH T3j OH 3511 CMe O Q1i a bond H a bond NH O a bond T3a OH3512 CMe O Q1i a bond H a bond NH O a bond T3b OH 3513 CMe O Q1i a bondH a bond NH O a bond T3c OH 3514 CMe O Q1i a bond H a bond NH O a bondT3d OH 3515 CMe O Q1i a bond H a bond NH O a bond T3e OH 3516 CMe O Q1ia bond H a bond NH O a bond T3f OH 3517 CMe O Q1i a bond H a bond NH O abond T3g OH 3518 CMe O Q1i a bond H a bond NH O a bond T3h OH 3519 CMe OQ1i a bond H a bond NH O a bond T3i OH 3520 CMe O Q1i a bond H a bond NHO a bond T3j OH 3521 CMe O Q1j a bond Me a bond NH S NH T3a OH 3522 CMeO Q1j a bond Me a bond NH S NH T3b OH 3523 CMe O Q1j a bond Me a bond NHS NH T3c OH 3524 CMe O Q1j a bond Me a bond NH S NH T3d OH 3525 CMe OQ1j a bond Me a bond NH S NH T3e OH 3526 CMe O Q1j a bond Me a bond NH SNH T3f OH 3527 CMe O Q1j a bond Me a bond NH S NH T3g OH 3528 CMe O Q1ja bond Me a bond NH S NH T3h OH 3529 CMe O Q1j a bond Me a bond NH S NHT3i OH 3530 CMe O Q1j a bond Me a bond NH S NH T3j OH 3531 CMe O Q1j abond Me a bond NH S a bond T3a OH 3532 CMe O Q1j a bond Me a bond NH S abond T3b OH 3533 CMe O Q1j a bond Me a bond NH S a bond T3c OH 3534 CMeO Q1j a bond Me a bond NH S a bond T3d OH 3535 CMe O Q1j a bond Me abond NH S a bond T3e OH 3536 CMe O Q1j a bond Me a bond NH S a bond T3fOH 3537 CMe O Q1j a bond Me a bond NH S a bond T3g OH 3538 CMe O Q1j abond Me a bond NH S a bond T3h OH 3539 CMe O Q1j a bond Me a bond NH S abond T3i OH 3540 CMe O Q1j a bond Me a bond NH S a bond T3j OH 3541 CMeO Q1j a bond Me a bond NH O NH T3a OH 3542 CMe O Q1j a bond Me a bond NHO NH T3b OH 3543 CMe O Q1j a bond Me a bond NH O NH T3c OH 3544 CMe OQ1j a bond Me a bond NH O NH T3d OH 3545 CMe O Q1j a bond Me a bond NH ONH T3e OH 3546 CMe O Q1j a bond Me a bond NH O NH T3f OH 3547 CMe O Q1ja bond Me a bond NH O NH T3g OH 3548 CMe O Q1j a bond Me a bond NH O NHT3h OH 3549 CMe O Q1j a bond Me a bond NH O NH T3i OH 3550 CMe O Q1j abond Me a bond NH O NH T3j OH 3551 CMe O Q1j a bond Me a bond NH O abond T3a OH 3552 CMe O Q1j a bond Me a bond NH O a bond T3b OH 3553 CMeO Q1j a bond Me a bond NH O a bond T3c OH 3554 CMe O Q1j a bond Me abond NH O a bond T3d OH 3555 CMe O Q1j a bond Me a bond NH O a bond T3eOH 3556 CMe O Q1j a bond Me a bond NH O a bond T3f OH 3557 CMe O Q1j abond Me a bond NH O a bond T3g OH 3558 CMe O Q1j a bond Me a bond NH O abond T3h OH 3559 CMe O Q1j a bond Me a bond NH O a bond T3i OH 3560 CMeO Q1j a bond Me a bond NH O a bond T3j OH 3561 CMe O Q1j a bond H a bondNH S NH T3a OH 3562 CMe O Q1j a bond H a bond NH S NH T3b OH 3563 CMe OQ1j a bond H a bond NH S NH T3c OH 3564 CMe O Q1j a bond H a bond NH SNH T3d OH 3565 CMe O Q1j a bond H a bond NH S NH T3e OH 3566 CMe O Q1j abond H a bond NH S NH T3f OH 3567 CMe O Q1j a bond H a bond NH S NH T3gOH 3568 CMe O Q1j a bond H a bond NH S NH T3h OH 3569 CMe O Q1j a bond Ha bond NH S NH T3i OH 3570 CMe O Q1j a bond H a bond NH S NH T3j OH 3571CMe O Q1j a bond H a bond NH S a bond T3a OH 3572 CMe O Q1j a bond H abond NH S a bond T3b OH 3573 CMe O Q1j a bond H a bond NH S a bond T3cOH 3574 CMe O Q1j a bond H a bond NH S a bond T3d OH 3575 CMe O Q1j abond H a bond NH S a bond T3e OH 3576 CMe O Q1j a bond H a bond NH S abond T3f OH 3577 CMe O Q1j a bond H a bond NH S a bond T3g OH 3578 CMe OQ1j a bond H a bond NH S a bond T3h OH 3579 CMe O Q1j a bond H a bond NHS a bond T3i OH 3580 CMe O Q1j a bond H a bond NH S a bond T3j OH 3581CMe O Q1j a bond H a bond NH O NH T3a OH 3582 CMe O Q1j a bond H a bondNH O NH T3b OH 3583 CMe O Q1j a bond H a bond NH O NH T3c OH 3584 CMe OQ1j a bond H a bond NH O NH T3d OH 3585 CMe O Q1j a bond H a bond NH ONH T3e OH 3586 CMe O Q1j a bond H a bond NH O NH T3f OH 3587 CMe O Q1j abond H a bond NH O NH T3g OH 3588 CMe O Q1j a bond H a bond NH O NH T3hOH 3589 CMe O Q1j a bond H a bond NH O NH T3i OH 3590 CMe O Q1j a bond Ha bond NH O NH T3j OH 3591 CMe O Q1j a bond H a bond NH O a bond T3a OH3592 CMe O Q1j a bond H a bond NH O a bond T3b OH 3593 CMe O Q1j a bondH a bond NH O a bond T3c OH 3594 CMe O Q1j a bond H a bond NH O a bondT3d OH 3595 CMe O Q1j a bond H a bond NH O a bond T3e OH 3596 CMe O Q1ja bond H a bond NH O a bond T3f OH 3597 CMe O Q1j a bond H a bond NH O abond T3g OH 3598 CMe O Q1j a bond H a bond NH O a bond T3h OH 3599 CMe OQ1j a bond H a bond NH O a bond T3i OH 3600 CMe O Q1j a bond H a bond NHO a bond T3j OH 3601 N NMe Q1i a bond Me a bond NH S NH Q3e OH 3602 NNMe Q1i a bond Me a bond NH S a bond Q3e OH 3603 N NMe Q1i a bond Me abond NH O NH Q3e OH 3604 N NMe Q1i a bond Me a bond NH O a bond Q3e OH3605 N NMe Q1i a bond H a bond NH S NH Q3e OH 3606 N NMe Q1i a bond H abond NH S a bond Q3e OH 3607 N NMe Q1i a bond H a bond NH O NH Q3e OH3608 N NMe Q1i a bond H a bond NH O a bond Q3e OH 3609 N NMe Q1j a bondMe a bond NH S NH Q3e OH 3610 N NMe Q1j a bond Me a bond NH S a bond Q3eOH 3611 N NMe Q1j a bond Me a bond NH O NH Q3e OH 3612 N NMe Q1j a bondMe a bond NH O a bond Q3e OH 3613 N NMe Q1j a bond H a bond NH S NH Q3eOH 3614 N NMe Q1j a bond H a bond NH S a bond Q3e OH 3615 N NMe Q1j abond H a bond NH O NH Q3e OH 3616 N NMe Q1j a bond H a bond NH O a bondQ3e OH 3617 N S Q1i a bond Me a bond NH S NH Q3e OH 3618 N S Q1i a bondMe a bond NH S a bond Q3e OH 3619 N S Q1i a bond Me a bond NH O NH Q3eOH 3620 N S Q1i a bond Me a bond NH O a bond Q3e OH 3621 N S Q1i a bondH a bond NH S NH Q3e OH 3622 N S Q1i a bond H a bond NH S a bond Q3e OH3623 N S Q1i a bond H a bond NH O NH Q3e OH 3624 N S Q1i a bond H a bondNH O a bond Q3e OH 3625 N S Q1j a bond Me a bond NH S NH Q3e OH 3626 N SQ1j a bond Me a bond NH S a bond Q3e OH 3627 N S Q1j a bond Me a bond NHO NH Q3e OH 3628 N S Q1j a bond Me a bond NH O a bond Q3e OH 3629 N SQ1j a bond H a bond NH S NH Q3e OH 3630 N S Q1j a bond H a bond NH S abond Q3e OH 3631 N S Q1j a bond H a bond NH O NH Q3e OH 3632 N S Q1j abond H a bond NH O a bond Q3e OH 3633 N O Q1i a bond Me a bond NH S NHQ3e OH 3634 N O Q1i a bond Me a bond NH S a bond Q3e OH 3635 N O Q1i abond Me a bond NH O NH Q3e OH 3636 N O Q1i a bond Me a bond NH O a bondQ3e OH 3637 N O Q1i a bond H a bond NH S NH Q3e OH 3638 N O Q1i a bond Ha bond NH S a bond Q3e OH 3639 N O Q1i a bond H a bond NH O NH Q3e OH3640 N O Q1i a bond H a bond NH O a bond Q3e OH 3641 N O Q1j a bond Me abond NH S NH Q3e OH 3642 N O Q1j a bond Me a bond NH S a bond Q3e OH3643 N O Q1j a bond Me a bond NH O NH Q3e OH 3644 N O Q1j a bond Me abond NH O a bond Q3e OH 3645 N O Q1j a bond H a bond NH S NH Q3e OH 3646N O Q1j a bond H a bond NH S a bond Q3e OH 3647 N O Q1j a bond H a bondNH O NH Q3e OH 3648 N O Q1j a bond H a bond NH O a bond Q3e OH 3649 CHNMe Q1i a bond Me a bond NH S NH Q3e OH 3650 CH NMe Q1i a bond Me a bondNH S a bond Q3e OH 3651 CH NMe Q1i a bond Me a bond NH O NH Q3e OH 3652CH NMe Q1i a bond Me a bond NH O a bond Q3e OH 3653 CH NMe Q1i a bond Ha bond NH S NH Q3e OH 3654 CH NMe Q1i a bond H a bond NH S a bond Q3e OH3655 CH NMe Q1i a bond H a bond NH O NH Q3e OH 3656 CH NMe Q1i a bond Ha bond NH O a bond Q3e OH 3657 CH NMe Q1j a bond Me a bond NH S NH Q3eOH 3658 CH NMe Q1j a bond Me a bond NH S a bond Q3e OH 3659 CH NMe Q1j abond Me a bond NH O NH Q3e OH 3660 CH NMe Q1j a bond Me a bond NH O abond Q3e OH 3661 CH NMe Q1j a bond H a bond NH S NH Q3e OH 3662 CH NMeQ1j a bond H a bond NH S a bond Q3e OH 3663 CH NMe Q1j a bond H a bondNH O NH Q3e OH 3664 CH NMe Q1j a bond H a bond NH O a bond Q3e OH 3665CH S Q1i a bond Me a bond NH S NH Q3e OH 3666 CH S Q1i a bond Me a bondNH S a bond Q3e OH 3667 CH S Q1i a bond Me a bond NH O NH Q3e OH 3668 CHS Q1i a bond Me a bond NH O a bond Q3e OH 3669 CH S Q1i a bond H a bondNH S NH Q3e OH 3670 CH S Q1i a bond H a bond NH S a bond Q3e OH 3671 CHS Q1i a bond H a bond NH O NH Q3e OH 3672 CH S Q1i a bond H a bond NH Oa bond Q3e OH 3673 CH S Q1j a bond Me a bond NH S NH Q3e OH 3674 CH SQ1j a bond Me a bond NH S a bond Q3e OH 3675 CH S Q1j a bond Me a bondNH O NH Q3e OH 3676 CH S Q1j a bond Me a bond NH O a bond Q3e OH 3677 CHS Q1j a bond H a bond NH S NH Q3e OH 3678 CH S Q1j a bond H a bond NH Sa bond Q3e OH 3679 CH S Q1j a bond H a bond NH O NH Q3e OH 3680 CH S Q1ja bond H a bond NH O a bond Q3e OH 3681 CH O Q1i a bond Me a bond NH SNH Q3e OH 3682 CH O Q1i a bond Me a bond NH S a bond Q3e OH 3683 CH OQ1i a bond Me a bond NH O NH Q3e OH 3684 CH O Q1i a bond Me a bond NH Oa bond Q3e OH 3685 CH O Q1i a bond H a bond NH S NH Q3e OH 3686 CH O Q1ia bond H a bond NH S a bond Q3e OH 3687 CH O Q1i a bond H a bond NH O NHQ3e OH 3688 CH O Q1i a bond H a bond NH O a bond Q3e OH 3689 CH O Q1j abond Me a bond NH S NH Q3e OH 3690 CH O Q1j a bond Me a bond NH S a bondQ3e OH 3691 CH O Q1j a bond Me a bond NH O NH Q3e OH 3692 CH O Q1j abond Me a bond NH O a bond Q3e OH 3693 CH O Q1j a bond H a bond NH S NHQ3e OH 3694 CH O Q1j a bond H a bond NH S a bond Q3e OH 3695 CH O Q1j abond H a bond NH O NH Q3e OH 3696 CH O Q1j a bond H a bond NH O a bondQ3e OH 3697 CMe NMe Q1i a bond Me a bond NH S NH Q3e OH 3698 CMe NMe Q1ia bond Me a bond NH S a bond Q3e OH 3699 CMe NMe Q1i a bond Me a bond NHO NH Q3e OH 3700 CMe NMe Q1i a bond Me a bond NH O a bond Q3e OH 3701CMe NMe Q1i a bond H a bond NH S NH Q3e OH 3702 CMe NMe Q1i a bond H abond NH S a bond Q3e OH 3703 CMe NMe Q1i a bond H a bond NH O NH Q3e OH3704 CMe NMe Q1i a bond H a bond NH O a bond Q3e OH 3705 CMe NMe Q1j abond Me a bond NH S NH Q3e OH 3706 CMe NMe Q1j a bond Me a bond NH S abond Q3e OH 3707 CMe NMe Q1j a bond Me a bond NH O NH Q3e OH 3708 CMeNMe Q1j a bond Me a bond NH O a bond Q3e OH 3709 CMe NMe Q1j a bond H abond NH S NH Q3e OH 3710 CMe NMe Q1j a bond H a bond NH S a bond Q3e OH3711 CMe NMe Q1j a bond H a bond NH O NH Q3e OH 3712 CMe NMe Q1j a bondH a bond NH O a bond Q3e OH 3713 CMe S Q1i a bond Me a bond NH S NH Q3eOH 3714 CMe S Q1i a bond Me a bond NH S a bond Q3e OH 3715 CMe S Q1i abond Me a bond NH O NH Q3e OH 3716 CMe S Q1i a bond Me a bond NH O abond Q3e OH 3717 CMe S Q1i a bond H a bond NH S NH Q3e OH 3718 CMe S Q1ia bond H a bond NH S a bond Q3e OH 3719 CMe S Q1i a bond H a bond NH ONH Q3e OH 3720 CMe S Q1i a bond H a bond NH O a bond Q3e OH 3721 CMe SQ1j a bond Me a bond NH S NH Q3e OH 3722 CMe S Q1j a bond Me a bond NH Sa bond Q3e OH 3723 CMe S Q1j a bond Me a bond NH O NH Q3e OH 3724 CMe SQ1j a bond Me a bond NH O a bond Q3e OH 3725 CMe S Q1j a bond H a bondNH S NH Q3e OH 3726 CMe S Q1j a bond H a bond NH S a bond Q3e OH 3727CMe S Q1j a bond H a bond NH O NH Q3e OH 3728 CMe S Q1j a bond H a bondNH O a bond Q3e OH 3729 CMe O Q1i a bond Me a bond NH S NH Q3e OH 3730CMe O Q1i a bond Me a bond NH S a bond Q3e OH 3731 CMe O Q1i a bond Me abond NH O NH Q3e OH 3732 CMe O Q1i a bond Me a bond NH O a bond Q3e OH3733 CMe O Q1i a bond H a bond NH S NH Q3e OH 3734 CMe O Q1i a bond H abond NH S a bond Q3e OH 3735 CMe O Q1i a bond H a bond NH O NH Q3e OH3736 CMe O Q1i a bond H a bond NH O a bond Q3e OH 3737 CMe O Q1j a bondMe a bond NH S NH Q3e OH 3738 CMe O Q1j a bond Me a bond NH S a bond Q3eOH 3739 CMe O Q1j a bond Me a bond NH O NH Q3e OH 3740 CMe O Q1j a bondMe a bond NH O a bond Q3e OH 3741 CMe O Q1j a bond H a bond NH S NH Q3eOH 3742 CMe O Q1j a bond H a bond NH S a bond Q3e OH 3743 CMe O Q1j abond H a bond NH O NH Q3e OH 3744 CMe O Q1j a bond H a bond NH O a bondQ3e OH 3745 N NMe Q1o′ a bond Me a bond NH S NH Q3a OH 3746 N NMe Q1o′ abond Me a bond NH S NH Q3e OH 3747 N NMe Q1o′ a bond Me a bond NH S NHT3a OH 3748 N NMe Q1o′ a bond Me a bond NH S NH T3b OH 3749 N NMe Q1o′ abond Me a bond NH S NH T3c OH 3750 N NMe Q1o′ a bond Me a bond NH S NHT3d OH 3751 N NMe Q1o′ a bond Me a bond NH S NH T3e OH 3752 N NMe Q1o′ abond Me a bond NH S NH T3f OH 3753 N NMe Q1o′ a bond Me a bond NH S NHT3g OH 3754 N NMe Q1o′ a bond Me a bond NH S NH T3h OH 3755 N NMe Q1o′ abond Me a bond NH S NH T3i OH 3756 N NMe Q1o′ a bond Me a bond NH S NHT3j OH 3757 N NMe Q1o′ a bond Me a bond NH S a bond Q3a OH 3758 N NMeQ1o′ a bond Me a bond NH S a bond Q3e OH 3759 N NMe Q1o′ a bond Me abond NH S a bond T3a OH 3760 N NMe Q1o′ a bond Me a bond NH S a bond T3bOH 3761 N NMe Q1o′ a bond Me a bond NH S a bond T3c OH 3762 N NMe Q1o′ abond Me a bond NH S a bond T3d OH 3763 N NMe Q1o′ a bond Me a bond NH Sa bond T3e OH 3764 N NMe Q1o′ a bond Me a bond NH S a bond T3f OH 3765 NNMe Q1o′ a bond Me a bond NH S a bond T3g OH 3766 N NMe Q1o′ a bond Me abond NH S a bond T3h OH 3767 N NMe Q1o′ a bond Me a bond NH S a bond T3iOH 3768 N NMe Q1o′ a bond Me a bond NH S a bond T3j OH 3769 N NMe Q1o′ abond Me a bond NH O NH Q3a OH 3770 N NMe Q1o′ a bond Me a bond NH O NHQ3e OH 3771 N NMe Q1o′ a bond Me a bond NH O NH T3a OH 3772 N NMe Q1o′ abond Me a bond NH O NH T3b OH 3773 N NMe Q1o′ a bond Me a bond NH O NHT3c OH 3774 N NMe Q1o′ a bond Me a bond NH O NH T3d OH 3775 N NMe Q1o′ abond Me a bond NH O NH T3e OH 3776 N NMe Q1o′ a bond Me a bond NH O NHT3f OH 3777 N NMe Q1o′ a bond Me a bond NH O NH T3g OH 3778 N NMe Q1o′ abond Me a bond NH O NH T3h OH 3779 N NMe Q1o′ a bond Me a bond NH O NHT3i OH 3780 N NMe Q1o′ a bond Me a bond NH O NH T3j OH 3781 N NMe Q1o′ abond Me a bond NH O a bond Q3a OH 3782 N NMe Q1o′ a bond Me a bond NH Oa bond Q3e OH 3783 N NMe Q1o′ a bond Me a bond NH O a bond T3a OH 3784 NNMe Q1o′ a bond Me a bond NH O a bond T3b OH 3785 N NMe Q1o′ a bond Me abond NH O a bond T3c OH 3786 N NMe Q1o′ a bond Me a bond NH O a bond T3dOH 3787 N NMe Q1o′ a bond Me a bond NH O a bond T3e OH 3788 N NMe Q1o′ abond Me a bond NH O a bond T3f OH 3789 N NMe Q1o′ a bond Me a bond NH Oa bond T3g OH 3790 N NMe Q1o′ a bond Me a bond NH O a bond T3h OH 3791 NNMe Q1o′ a bond Me a bond NH O a bond T3i OH 3792 N NMe Q1o′ a bond Me abond NH O a bond T3j OH 3793 N NMe Q1o′ a bond H a bond NH S NH Q3a OH3794 N NMe Q1o′ a bond H a bond NH S NH Q3e OH 3795 N NMe Q1o′ a bond Ha bond NH S NH T3a OH 3796 N NMe Q1o′ a bond H a bond NH S NH T3b OH3797 N NMe Q1o′ a bond H a bond NH S NH T3c OH 3798 N NMe Q1o′ a bond Ha bond NH S NH T3d OH 3799 N NMe Q1o′ a bond H a bond NH S NH T3e OH3800 N NMe Q1o′ a bond H a bond NH S NH T3f OH 3801 N NMe Q1o′ a bond Ha bond NH S NH T3g OH 3802 N NMe Q1o′ a bond H a bond NH S NH T3h OH3803 N NMe Q1o′ a bond H a bond NH S NH T3i OH 3804 N NMe Q1o′ a bond Ha bond NH S NH T3j OH 3805 N NMe Q1o′ a bond H a bond NH S a bond Q3a OH3806 N NMe Q1o′ a bond H a bond NH S a bond Q3e OH 3807 N NMe Q1o′ abond H a bond NH S a bond T3a OH 3808 N NMe Q1o′ a bond H a bond NH S abond T3b OH 3809 N NMe Q1o′ a bond H a bond NH S a bond T3c OH 3810 NNMe Q1o′ a bond H a bond NH S a bond T3d OH 3811 N NMe Q1o′ a bond H abond NH S a bond T3e OH 3812 N NMe Q1o′ a bond H a bond NH S a bond T3fOH 3813 N NMe Q1o′ a bond H a bond NH S a bond T3g OH 3814 N NMe Q1o′ abond H a bond NH S a bond T3h OH 3815 N NMe Q1o′ a bond H a bond NH S abond T3i OH 3816 N NMe Q1o′ a bond H a bond NH S a bond T3j OH 3817 NNMe Q1o′ a bond H a bond NH O NH Q3a OH 3818 N NMe Q1o′ a bond H a bondNH O NH Q3e OH 3819 N NMe Q1o′ a bond H a bond NH O NH T3a OH 3820 N NMeQ1o′ a bond H a bond NH O NH T3b OH 3821 N NMe Q1o′ a bond H a bond NH ONH T3c OH 3822 N NMe Q1o′ a bond H a bond NH O NH T3d OH 3823 N NMe Q1o′a bond H a bond NH O NH T3e OH 3824 N NMe Q1o′ a bond H a bond NH O NHT3f OH 3825 N NMe Q1o′ a bond H a bond NH O NH T3g OH 3826 N NMe Q1o′ abond H a bond NH O NH T3h OH 3827 N NMe Q1o′ a bond H a bond NH O NH T3iOH 3828 N NMe Q1o′ a bond H a bond NH O NH T3j OH 3829 N NMe Q1o′ a bondH a bond NH O a bond Q3a OH 3830 N NMe Q1o′ a bond H a bond NH O a bondQ3e OH 3831 N NMe Q1o′ a bond H a bond NH O a bond T3a OH 3832 N NMeQ1o′ a bond H a bond NH O a bond T3b OH 3833 N NMe Q1o′ a bond H a bondNH O a bond T3c OH 3834 N NMe Q1o′ a bond H a bond NH O a bond T3d OH3835 N NMe Q1o′ a bond H a bond NH O a bond T3e OH 3836 N NMe Q1o′ abond H a bond NH O a bond T3f OH 3837 N NMe Q1o′ a bond H a bond NH O abond T3g OH 3838 N NMe Q1o′ a bond H a bond NH O a bond T3h OH 3839 NNMe Q1o′ a bond H a bond NH O a bond T3i OH 3840 N NMe Q1o′ a bond H abond NH O a bond T3j OH 3841 N S Q1o′ a bond Me a bond NH S NH Q3a OH3842 N S Q1o′ a bond Me a bond NH S NH Q3e OH 3843 N S Q1o′ a bond Me abond NH S NH T3a OH 3844 N S Q1o′ a bond Me a bond NH S NH T3b OH 3845 NS Q1o′ a bond Me a bond NH S NH T3c OH 3846 N S Q1o′ a bond Me a bond NHS NH T3d OH 3847 N S Q1o′ a bond Me a bond NH S NH T3e OH 3848 N S Q1o′a bond Me a bond NH S NH T3f OH 3849 N S Q1o′ a bond Me a bond NH S NHT3g OH 3850 N S Q1o′ a bond Me a bond NH S NH T3h OH 3851 N S Q1o′ abond Me a bond NH S NH T3i OH 3852 N S Q1o′ a bond Me a bond NH S NH T3jOH 3853 N S Q1o′ a bond Me a bond NH S a bond Q3a OH 3854 N S Q1o′ abond Me a bond NH S a bond Q3e OH 3855 N S Q1o′ a bond Me a bond NH S abond T3a OH 3856 N S Q1o′ a bond Me a bond NH S a bond T3b OH 3857 N SQ1o′ a bond Me a bond NH S a bond T3c OH 3858 N S Q1o′ a bond Me a bondNH S a bond T3d OH 3859 N S Q1o′ a bond Me a bond NH S a bond T3e OH3860 N S Q1o′ a bond Me a bond NH S a bond T3f OH 3861 N S Q1o′ a bondMe a bond NH S a bond T3g OH 3862 N S Q1o′ a bond Me a bond NH S a bondT3h OH 3863 N S Q1o′ a bond Me a bond NH S a bond T3i OH 3864 N S Q1o′ abond Me a bond NH S a bond T3j OH 3865 N S Q1o′ a bond Me a bond NH O NHQ3a OH 3866 N S Q1o′ a bond Me a bond NH O NH Q3e OH 3867 N S Q1o′ abond Me a bond NH O NH T3a OH 3868 N S Q1o′ a bond Me a bond NH O NH T3bOH 3869 N S Q1o′ a bond Me a bond NH O NH T3c OH 3870 N S Q1o′ a bond Mea bond NH O NH T3d OH 3871 N S Q1o′ a bond Me a bond NH O NH T3e OH 3872N S Q1o′ a bond Me a bond NH O NH T3f OH 3873 N S Q1o′ a bond Me a bondNH O NH T3g OH 3874 N S Q1o′ a bond Me a bond NH O NH T3h OH 3875 N SQ1o′ a bond Me a bond NH O NH T3i OH 3876 N S Q1o′ a bond Me a bond NH ONH T3j OH 3877 N S Q1o′ a bond Me a bond NH O a bond Q3a OH 3878 N SQ1o′ a bond Me a bond NH O a bond Q3e OH 3879 N S Q1o′ a bond Me a bondNH O a bond T3a OH 3880 N S Q1o′ a bond Me a bond NH O a bond T3b OH3881 N S Q1o′ a bond Me a bond NH O a bond T3c OH 3882 N S Q1o′ a bondMe a bond NH O a bond T3d OH 3883 N S Q1o′ a bond Me a bond NH O a bondT3e OH 3884 N S Q1o′ a bond Me a bond NH O a bond T3f OH 3885 N S Q1o′ abond Me a bond NH O a bond T3g OH 3886 N S Q1o′ a bond Me a bond NH O abond T3h OH 3887 N S Q1o′ a bond Me a bond NH O a bond T3i OH 3888 N SQ1o′ a bond Me a bond NH O a bond T3j OH 3889 N S Q1o′ a bond H a bondNH S NH Q3a OH 3890 N S Q1o′ a bond H a bond NH S NH Q3e OH 3891 N SQ1o′ a bond H a bond NH S NH T3a OH 3892 N S Q1o′ a bond H a bond NH SNH T3b OH 3893 N S Q1o′ a bond H a bond NH S NH T3c OH 3894 N S Q1o′ abond H a bond NH S NH T3d OH 3895 N S Q1o′ a bond H a bond NH S NH T3eOH 3896 N S Q1o′ a bond H a bond NH S NH T3f OH 3897 N S Q1o′ a bond H abond NH S NH T3g OH 3898 N S Q1o′ a bond H a bond NH S NH T3h OH 3899 NS Q1o′ a bond H a bond NH S NH T3i OH 3900 N S Q1o′ a bond H a bond NH SNH T3j OH 3901 N S Q1o′ a bond H a bond NH S a bond Q3a OH 3902 N S Q1o′a bond H a bond NH S a bond Q3e OH 3903 N S Q1o′ a bond H a bond NH S abond T3a OH 3904 N S Q1o′ a bond H a bond NH S a bond T3b OH 3905 N SQ1o′ a bond H a bond NH S a bond T3c OH 3906 N S Q1o′ a bond H a bond NHS a bond T3d OH 3907 N S Q1o′ a bond H a bond NH S a bond T3e OH 3908 NS Q1o′ a bond H a bond NH S a bond T3f OH 3909 N S Q1o′ a bond H a bondNH S a bond T3g OH 3910 N S Q1o′ a bond H a bond NH S a bond T3h OH 3911N S Q1o′ a bond H a bond NH S a bond T3i OH 3912 N S Q1o′ a bond H abond NH S a bond T3j OH 3913 N S Q1o′ a bond H a bond NH O NH Q3a OH3914 N S Q1o′ a bond H a bond NH O NH Q3e OH 3915 N S Q1o′ a bond H abond NH O NH T3a OH 3916 N S Q1o′ a bond H a bond NH O NH T3b OH 3917 NS Q1o′ a bond H a bond NH O NH T3c OH 3918 N S Q1o′ a bond H a bond NH ONH T3d OH 3919 N S Q1o′ a bond H a bond NH O NH T3e OH 3920 N S Q1o′ abond H a bond NH O NH T3f OH 3921 N S Q1o′ a bond H a bond NH O NH T3gOH 3922 N S Q1o′ a bond H a bond NH O NH T3h OH 3923 N S Q1o′ a bond H abond NH O NH T3i OH 3924 N S Q1o′ a bond H a bond NH O NH T3j OH 3925 NS Q1o′ a bond H a bond NH O a bond Q3a OH 3926 N S Q1o′ a bond H a bondNH O a bond Q3e OH 3927 N S Q1o′ a bond H a bond NH O a bond T3a OH 3928N S Q1o′ a bond H a bond NH O a bond T3b OH 3929 N S Q1o′ a bond H abond NH O a bond T3c OH 3930 N S Q1o′ a bond H a bond NH O a bond T3d OH3931 N S Q1o′ a bond H a bond NH O a bond T3e OH 3932 N S Q1o′ a bond Ha bond NH O a bond T3f OH 3933 N S Q1o′ a bond H a bond NH O a bond T3gOH 3934 N S Q1o′ a bond H a bond NH O a bond T3h OH 3935 N S Q1o′ a bondH a bond NH O a bond T3i OH 3936 N S Q1o′ a bond H a bond NH O a bondT3j OH 3937 N O Q1o′ a bond Me a bond NH S NH Q3a OH 3938 N O Q1o′ abond Me a bond NH S NH Q3e OH 3939 N O Q1o′ a bond Me a bond NH S NH T3aOH 3940 N O Q1o′ a bond Me a bond NH S NH T3b OH 3941 N O Q1o′ a bond Mea bond NH S NH T3c OH 3942 N O Q1o′ a bond Me a bond NH S NH T3d OH 3943N O Q1o′ a bond Me a bond NH S NH T3e OH 3944 N O Q1o′ a bond Me a bondNH S NH T3f OH 3945 N O Q1o′ a bond Me a bond NH S NH T3g OH 3946 N OQ1o′ a bond Me a bond NH S NH T3h OH 3947 N O Q1o′ a bond Me a bond NH SNH T3i OH 3948 N O Q1o′ a bond Me a bond NH S NH T3j OH 3949 N O Q1o′ abond Me a bond NH S a bond Q3a OH 3950 N O Q1o′ a bond Me a bond NH S abond Q3e OH 3951 N O Q1o′ a bond Me a bond NH S a bond T3a OH 3952 N OQ1o′ a bond Me a bond NH S a bond T3b OH 3953 N O Q1o′ a bond Me a bondNH S a bond T3c OH 3954 N O Q1o′ a bond Me a bond NH S a bond T3d OH3955 N O Q1o′ a bond Me a bond NH S a bond T3e OH 3956 N O Q1o′ a bondMe a bond NH S a bond T3f OH 3957 N O Q1o′ a bond Me a bond NH S a bondT3g OH 3958 N O Q1o′ a bond Me a bond NH S a bond T3h OH 3959 N O Q1o′ abond Me a bond NH S a bond T3i OH 3960 N O Q1o′ a bond Me a bond NH S abond T3j OH 3961 N O Q1o′ a bond Me a bond NH O NH Q3a OH 3962 N O Q1o′a bond Me a bond NH O NH Q3e OH 3963 N O Q1o′ a bond Me a bond NH O NHT3a OH 3964 N O Q1o′ a bond Me a bond NH O NH T3b OH 3965 N O Q1o′ abond Me a bond NH O NH T3c OH 3966 N O Q1o′ a bond Me a bond NH O NH T3dOH 3967 N O Q1o′ a bond Me a bond NH O NH T3e OH 3968 N O Q1o′ a bond Mea bond NH O NH T3f OH 3969 N O Q1o′ a bond Me a bond NH O NH T3g OH 3970N O Q1o′ a bond Me a bond NH O NH T3h OH 3971 N O Q1o′ a bond Me a bondNH O NH T3i OH 3972 N O Q1o′ a bond Me a bond NH O NH T3j OH 3973 N OQ1o′ a bond Me a bond NH O a bond Q3a OH 3974 N O Q1o′ a bond Me a bondNH O a bond Q3e OH 3975 N O Q1o′ a bond Me a bond NH O a bond T3a OH3976 N O Q1o′ a bond Me a bond NH O a bond T3b OH 3977 N O Q1o′ a bondMe a bond NH O a bond T3c OH 3978 N O Q1o′ a bond Me a bond NH O a bondT3d OH 3979 N O Q1o′ a bond Me a bond NH O a bond T3e OH 3980 N O Q1o′ abond Me a bond NH O a bond T3f OH 3981 N O Q1o′ a bond Me a bond NH O abond T3g OH 3982 N O Q1o′ a bond Me a bond NH O a bond T3h OH 3983 N OQ1o′ a bond Me a bond NH O a bond T3i OH 3984 N O Q1o′ a bond Me a bondNH O a bond T3j OH 3985 N O Q1o′ a bond H a bond NH S NH Q3a OH 3986 N OQ1o′ a bond H a bond NH S NH Q3e OH 3987 N O Q1o′ a bond H a bond NH SNH T3a OH 3988 N O Q1o′ a bond H a bond NH S NH T3b OH 3989 N O Q1o′ abond H a bond NH S NH T3c OH 3990 N O Q1o′ a bond H a bond NH S NH T3dOH 3991 N O Q1o′ a bond H a bond NH S NH T3e OH 3992 N O Q1o′ a bond H abond NH S NH T3f OH 3993 N O Q1o′ a bond H a bond NH S NH T3g OH 3994 NO Q1o′ a bond H a bond NH S NH T3h OH 3995 N O Q1o′ a bond H a bond NH SNH T3i OH 3996 N O Q1o′ a bond H a bond NH S NH T3j OH 3997 N O Q1o′ abond H a bond NH S a bond Q3a OH 3998 N O Q1o′ a bond H a bond NH S abond Q3e OH 3999 N O Q1o′ a bond H a bond NH S a bond T3a OH 4000 N OQ1o′ a bond H a bond NH S a bond T3b OH 4001 N O Q1o′ a bond H a bond NHS a bond T3c OH 4002 N O Q1o′ a bond H a bond NH S a bond T3d OH 4003 NO Q1o′ a bond H a bond NH S a bond T3e OH 4004 N O Q1o′ a bond H a bondNH S a bond T3f OH 4005 N O Q1o′ a bond H a bond NH S a bond T3g OH 4006N O Q1o′ a bond H a bond NH S a bond T3h OH 4007 N O Q1o′ a bond H abond NH S a bond T3i OH 4008 N O Q1o′ a bond H a bond NH S a bond T3j OH4009 N O Q1o′ a bond H a bond NH O NH Q3a OH 4010 N O Q1o′ a bond H abond NH O NH Q3e OH 4011 N O Q1o′ a bond H a bond NH O NH T3a OH 4012 NO Q1o′ a bond H a bond NH O NH T3b OH 4013 N O Q1o′ a bond H a bond NH ONH T3c OH 4014 N O Q1o′ a bond H a bond NH O NH T3d OH 4015 N O Q1o′ abond H a bond NH O NH T3e OH 4016 N O Q1o′ a bond H a bond NH O NH T3fOH 4017 N O Q1o′ a bond H a bond NH O NH T3g OH 4018 N O Q1o′ a bond H abond NH O NH T3h OH 4019 N O Q1o′ a bond H a bond NH O NH T3i OH 4020 NO Q1o′ a bond H a bond NH O NH T3j OH 4021 N O Q1o′ a bond H a bond NH Oa bond Q3a OH 4022 N O Q1o′ a bond H a bond NH O a bond Q3e OH 4023 N OQ1o′ a bond H a bond NH O a bond T3a OH 4024 N O Q1o′ a bond H a bond NHO a bond T3b OH 4025 N O Q1o′ a bond H a bond NH O a bond T3c OH 4026 NO Q1o′ a bond H a bond NH O a bond T3d OH 4027 N O Q1o′ a bond H a bondNH O a bond T3e OH 4028 N O Q1o′ a bond H a bond NH O a bond T3f OH 4029N O Q1o′ a bond H a bond NH O a bond T3g OH 4030 N O Q1o′ a bond H abond NH O a bond T3h OH 4031 N O Q1o′ a bond H a bond NH O a bond T3i OH4032 N O Q1o′ a bond H a bond NH O a bond T3j OH 4033 CH NMe Q1o′ a bondMe a bond NH S NH Q3a OH 4034 CH NMe Q1o′ a bond Me a bond NH S NH Q3eOH 4035 CH NMe Q1o′ a bond Me a bond NH S NH T3a OH 4036 CH NMe Q1o′ abond Me a bond NH S NH T3b OH 4037 CH NMe Q1o′ a bond Me a bond NH S NHT3c OH 4038 CH NMe Q1o′ a bond Me a bond NH S NH T3d OH 4039 CH NMe Q1o′a bond Me a bond NH S NH T3e OH 4040 CH NMe Q1o′ a bond Me a bond NH SNH T3f OH 4041 CH NMe Q1o′ a bond Me a bond NH S NH T3g OH 4042 CH NMeQ1o′ a bond Me a bond NH S NH T3h OH 4043 CH NMe Q1o′ a bond Me a bondNH S NH T3i OH 4044 CH NMe Q1o′ a bond Me a bond NH S NH T3j OH 4045 CHNMe Q1o′ a bond Me a bond NH S a bond Q3a OH 4046 CH NMe Q1o′ a bond Mea bond NH S a bond Q3e OH 4047 CH NMe Q1o′ a bond Me a bond NH S a bondT3a OH 4048 CH NMe Q1o′ a bond Me a bond NH S a bond T3b OH 4049 CH NMeQ1o′ a bond Me a bond NH S a bond T3c OH 4050 CH NMe Q1o′ a bond Me abond NH S a bond T3d OH 4051 CH NMe Q1o′ a bond Me a bond NH S a bondT3e OH 4052 CH NMe Q1o′ a bond Me a bond NH S a bond T3f OH 4053 CH NMeQ1o′ a bond Me a bond NH S a bond T3g OH 4054 CH NMe Q1o′ a bond Me abond NH S a bond T3h OH 4055 CH NMe Q1o′ a bond Me a bond NH S a bondT3i OH 4056 CH NMe Q1o′ a bond Me a bond NH S a bond T3j OH 4057 CH NMeQ1o′ a bond Me a bond NH O NH Q3a OH 4058 CH NMe Q1o′ a bond Me a bondNH O NH Q3e OH 4059 CH NMe Q1o′ a bond Me a bond NH O NH T3a OH 4060 CHNMe Q1o′ a bond Me a bond NH O NH T3b OH 4061 CH NMe Q1o′ a bond Me abond NH O NH T3c OH 4062 CH NMe Q1o′ a bond Me a bond NH O NH T3d OH4063 CH NMe Q1o′ a bond Me a bond NH O NH T3e OH 4064 CH NMe Q1o′ a bondMe a bond NH O NH T3f OH 4065 CH NMe Q1o′ a bond Me a bond NH O NH T3gOH 4066 CH NMe Q1o′ a bond Me a bond NH O NH T3h OH 4067 CH NMe Q1o′ abond Me a bond NH O NH T3i OH 4068 CH NMe Q1o′ a bond Me a bond NH O NHT3j OH 4069 CH NMe Q1o′ a bond Me a bond NH O a bond Q3a OH 4070 CH NMeQ1o′ a bond Me a bond NH O a bond Q3e OH 4071 CH NMe Q1o′ a bond Me abond NH O a bond T3a OH 4072 CH NMe Q1o′ a bond Me a bond NH O a bondT3b OH 4073 CH NMe Q1o′ a bond Me a bond NH O a bond T3c OH 4074 CH NMeQ1o′ a bond Me a bond NH O a bond T3d OH 4075 CH NMe Q1o′ a bond Me abond NH O a bond T3e OH 4076 CH NMe Q1o′ a bond Me a bond NH O a bondT3f OH 4077 CH NMe Q1o′ a bond Me a bond NH O a bond T3g OH 4078 CH NMeQ1o′ a bond Me a bond NH O a bond T3h OH 4079 CH NMe Q1o′ a bond Me abond NH O a bond T3i OH 4080 CH NMe Q1o′ a bond Me a bond NH O a bondT3j OH 4081 CH NMe Q1o′ a bond H a bond NH S NH Q3a OH 4082 CH NMe Q1o′a bond H a bond NH S NH Q3e OH 4083 CH NMe Q1o′ a bond H a bond NH S NHT3a OH 4084 CH NMe Q1o′ a bond H a bond NH S NH T3b OH 4085 CH NMe Q1o′a bond H a bond NH S NH T3c OH 4086 CH NMe Q1o′ a bond H a bond NH S NHT3d OH 4087 CH NMe Q1o′ a bond H a bond NH S NH T3e OH 4088 CH NMe Q1o′a bond H a bond NH S NH T3f OH 4089 CH NMe Q1o′ a bond H a bond NH S NHT3g OH 4090 CH NMe Q1o′ a bond H a bond NH S NH T3h OH 4091 CH NMe Q1o′a bond H a bond NH S NH T3i OH 4092 CH NMe Q1o′ a bond H a bond NH S NHT3j OH 4093 CH NMe Q1o′ a bond H a bond NH S a bond Q3a OH 4094 CH NMeQ1o′ a bond H a bond NH S a bond Q3e OH 4095 CH NMe Q1o′ a bond H a bondNH S a bond T3a OH 4096 CH NMe Q1o′ a bond H a bond NH S a bond T3b OH4097 CH NMe Q1o′ a bond H a bond NH S a bond T3c OH 4098 CH NMe Q1o′ abond H a bond NH S a bond T3d OH 4099 CH NMe Q1o′ a bond H a bond NH S abond T3e OH 4100 CH NMe Q1o′ a bond H a bond NH S a bond T3f OH 4101 CHNMe Q1o′ a bond H a bond NH S a bond T3g OH 4102 CH NMe Q1o′ a bond H abond NH S a bond T3h OH 4103 CH NMe Q1o′ a bond H a bond NH S a bond T3iOH 4104 CH NMe Q1o′ a bond H a bond NH S a bond T3j OH 4105 CH NMe Q1o′a bond H a bond NH O NH Q3a OH 4106 CH NMe Q1o′ a bond H a bond NH O NHQ3e OH 4107 CH NMe Q1o′ a bond H a bond NH O NH T3a OH 4108 CH NMe Q1o′a bond H a bond NH O NH T3b OH 4109 CH NMe Q1o′ a bond H a bond NH O NHT3c OH 4110 CH NMe Q1o′ a bond H a bond NH O NH T3d OH 4111 CH NMe Q1o′a bond H a bond NH O NH T3e OH 4112 CH NMe Q1o′ a bond H a bond NH O NHT3f OH 4113 CH NMe Q1o′ a bond H a bond NH O NH T3g OH 4114 CH NMe Q1o′a bond H a bond NH O NH T3h OH 4115 CH NMe Q1o′ a bond H a bond NH O NHT3i OH 4116 CH NMe Q1o′ a bond H a bond NH O NH T3j OH 4117 CH NMe Q1o′a bond H a bond NH O a bond Q3a OH 4118 CH NMe Q1o′ a bond H a bond NH Oa bond Q3e OH 4119 CH NMe Q1o′ a bond H a bond NH O a bond T3a OH 4120CH NMe Q1o′ a bond H a bond NH O a bond T3b OH 4121 CH NMe Q1o′ a bond Ha bond NH O a bond T3c OH 4122 CH NMe Q1o′ a bond H a bond NH O a bondT3d OH 4123 CH NMe Q1o′ a bond H a bond NH O a bond T3e OH 4124 CH NMeQ1o′ a bond H a bond NH O a bond T3f OH 4125 CH NMe Q1o′ a bond H a bondNH O a bond T3g OH 4126 CH NMe Q1o′ a bond H a bond NH O a bond T3h OH4127 CH NMe Q1o′ a bond H a bond NH O a bond T3i OH 4128 CH NMe Q1o′ abond H a bond NH O a bond T3j OH 4129 CH S Q1o′ a bond Me a bond NH S NHQ3a OH 4130 CH S Q1o′ a bond Me a bond NH S NH Q3e OH 4131 CH S Q1o′ abond Me a bond NH S NH T3a OH 4132 CH S Q1o′ a bond Me a bond NH S NHT3b OH 4133 CH S Q1o′ a bond Me a bond NH S NH T3c OH 4134 CH S Q1o′ abond Me a bond NH S NH T3d OH 4135 CH S Q1o′ a bond Me a bond NH S NHT3e OH 4136 CH S Q1o′ a bond Me a bond NH S NH T3f OH 4137 CH S Q1o′ abond Me a bond NH S NH T3g OH 4138 CH S Q1o′ a bond Me a bond NH S NHT3h OH 4139 CH S Q1o′ a bond Me a bond NH S NH T3i OH 4140 CH S Q1o′ abond Me a bond NH S NH T3j OH 4141 CH S Q1o′ a bond Me a bond NH S abond Q3a OH 4142 CH S Q1o′ a bond Me a bond NH S a bond Q3e OH 4143 CH SQ1o′ a bond Me a bond NH S a bond T3a OH 4144 CH S Q1o′ a bond Me a bondNH S a bond T3b OH 4145 CH S Q1o′ a bond Me a bond NH S a bond T3c OH4146 CH S Q1o′ a bond Me a bond NH S a bond T3d OH 4147 CH S Q1o′ a bondMe a bond NH S a bond T3e OH 4148 CH S Q1o′ a bond Me a bond NH S a bondT3f OH 4149 CH S Q1o′ a bond Me a bond NH S a bond T3g OH 4150 CH S Q1o′a bond Me a bond NH S a bond T3h OH 4151 CH S Q1o′ a bond Me a bond NH Sa bond T3i OH 4152 CH S Q1o′ a bond Me a bond NH S a bond T3j OH 4153 CHS Q1o′ a bond Me a bond NH O NH Q3a OH 4154 CH S Q1o′ a bond Me a bondNH O NH Q3e OH 4155 CH S Q1o′ a bond Me a bond NH O NH T3a OH 4156 CH SQ1o′ a bond Me a bond NH O NH T3b OH 4157 CH S Q1o′ a bond Me a bond NHO NH T3c OH 4158 CH S Q1o′ a bond Me a bond NH O NH T3d OH 4159 CH SQ1o′ a bond Me a bond NH O NH T3e OH 4160 CH S Q1o′ a bond Me a bond NHO NH T3f OH 4161 CH S Q1o′ a bond Me a bond NH O NH T3g OH 4162 CH SQ1o′ a bond Me a bond NH O NH T3h OH 4163 CH S Q1o′ a bond Me a bond NHO NH T3i OH 4164 CH S Q1o′ a bond Me a bond NH O NH T3j OH 4165 CH SQ1o′ a bond Me a bond NH O a bond Q3a OH 4166 CH S Q1o′ a bond Me a bondNH O a bond Q3e OH 4167 CH S Q1o′ a bond Me a bond NH O a bond T3a OH4168 CH S Q1o′ a bond Me a bond NH O a bond T3b OH 4169 CH S Q1o′ a bondMe a bond NH O a bond T3c OH 4170 CH S Q1o′ a bond Me a bond NH O a bondT3d OH 4171 CH S Q1o′ a bond Me a bond NH O a bond T3e OH 4172 CH S Q1o′a bond Me a bond NH O a bond T3f OH 4173 CH S Q1o′ a bond Me a bond NH Oa bond T3g OH 4174 CH S Q1o′ a bond Me a bond NH O a bond T3h OH 4175 CHS Q1o′ a bond Me a bond NH O a bond T3i OH 4176 CH S Q1o′ a bond Me abond NH O a bond T3j OH 4177 CH S Q1o′ a bond H a bond NH S NH Q3a OH4178 CH S Q1o′ a bond H a bond NH S NH Q3e OH 4179 CH S Q1o′ a bond H abond NH S NH T3a OH 4180 CH S Q1o′ a bond H a bond NH S NH T3b OH 4181CH S Q1o′ a bond H a bond NH S NH T3c OH 4182 CH S Q1o′ a bond H a bondNH S NH T3d OH 4183 CH S Q1o′ a bond H a bond NH S NH T3e OH 4184 CH SQ1o′ a bond H a bond NH S NH T3f OH 4185 CH S Q1o′ a bond H a bond NH SNH T3g OH 4186 CH S Q1o′ a bond H a bond NH S NH T3h OH 4187 CH S Q1o′ abond H a bond NH S NH T3i OH 4188 CH S Q1o′ a bond H a bond NH S NH T3jOH 4189 CH S Q1o′ a bond H a bond NH S a bond Q3a OH 4190 CH S Q1o′ abond H a bond NH S a bond Q3e OH 4191 CH S Q1o′ a bond H a bond NH S abond T3a OH 4192 CH S Q1o′ a bond H a bond NH S a bond T3b OH 4193 CH SQ1o′ a bond H a bond NH S a bond T3c OH 4194 CH S Q1o′ a bond H a bondNH S a bond T3d OH 4195 CH S Q1o′ a bond H a bond NH S a bond T3e OH4196 CH S Q1o′ a bond H a bond NH S a bond T3f OH 4197 CH S Q1o′ a bondH a bond NH S a bond T3g OH 4198 CH S Q1o′ a bond H a bond NH S a bondT3h OH 4199 CH S Q1o′ a bond H a bond NH S a bond T3i OH 4200 CH S Q1o′a bond H a bond NH S a bond T3j OH 4201 CH S Q1o′ a bond H a bond NH ONH Q3a OH 4202 CH S Q1o′ a bond H a bond NH O NH Q3e OH 4203 CH S Q1o′ abond H a bond NH O NH T3a OH 4204 CH S Q1o′ a bond H a bond NH O NH T3bOH 4205 CH S Q1o′ a bond H a bond NH O NH T3c OH 4206 CH S Q1o′ a bond Ha bond NH O NH T3d OH 4207 CH S Q1o′ a bond H a bond NH O NH T3e OH 4208CH S Q1o′ a bond H a bond NH O NH T3f OH 4209 CH S Q1o′ a bond H a bondNH O NH T3g OH 4210 CH S Q1o′ a bond H a bond NH O NH T3h OH 4211 CH SQ1o′ a bond H a bond NH O NH T3i OH 4212 CH S Q1o′ a bond H a bond NH ONH T3j OH 4213 CH S Q1o′ a bond H a bond NH O a bond Q3a OH 4214 CH SQ1o′ a bond H a bond NH O a bond Q3e OH 4215 CH S Q1o′ a bond H a bondNH O a bond T3a OH 4216 CH S Q1o′ a bond H a bond NH O a bond T3b OH4217 CH S Q1o′ a bond H a bond NH O a bond T3c OH 4218 CH S Q1o′ a bondH a bond NH O a bond T3d OH 4219 CH S Q1o′ a bond H a bond NH O a bondT3e OH 4220 CH S Q1o′ a bond H a bond NH O a bond T3f OH 4221 CH S Q1o′a bond H a bond NH O a bond T3g OH 4222 CH S Q1o′ a bond H a bond NH O abond T3h OH 4223 CH S Q1o′ a bond H a bond NH O a bond T3i OH 4224 CH SQ1o′ a bond H a bond NH O a bond T3j OH 4225 CH O Q1o′ a bond Me a bondNH S NH Q3a OH 4226 CH O Q1o′ a bond Me a bond NH S NH Q3e OH 4227 CH OQ1o′ a bond Me a bond NH S NH T3a OH 4228 CH O Q1o′ a bond Me a bond NHS NH T3b OH 4229 CH O Q1o′ a bond Me a bond NH S NH T3c OH 4230 CH OQ1o′ a bond Me a bond NH S NH T3d OH 4231 CH O Q1o′ a bond Me a bond NHS NH T3e OH 4232 CH O Q1o′ a bond Me a bond NH S NH T3f OH 4233 CH OQ1o′ a bond Me a bond NH S NH T3g OH 4234 CH O Q1o′ a bond Me a bond NHS NH T3h OH 4235 CH O Q1o′ a bond Me a bond NH S NH T3i OH 4236 CH OQ1o′ a bond Me a bond NH S NH T3j OH 4237 CH O Q1o′ a bond Me a bond NHS a bond Q3a OH 4238 CH O Q1o′ a bond Me a bond NH S a bond Q3e OH 4239CH O Q1o′ a bond Me a bond NH S a bond T3a OH 4240 CH O Q1o′ a bond Me abond NH S a bond T3b OH 4241 CH O Q1o′ a bond Me a bond NH S a bond T3cOH 4242 CH O Q1o′ a bond Me a bond NH S a bond T3d OH 4243 CH O Q1o′ abond Me a bond NH S a bond T3e OH 4244 CH O Q1o′ a bond Me a bond NH S abond T3f OH 4245 CH O Q1o′ a bond Me a bond NH S a bond T3g OH 4246 CH OQ1o′ a bond Me a bond NH S a bond T3h OH 4247 CH O Q1o′ a bond Me a bondNH S a bond T3i OH 4248 CH O Q1o′ a bond Me a bond NH S a bond T3j OH4249 CH O Q1o′ a bond Me a bond NH O NH Q3a OH 4250 CH O Q1o′ a bond Mea bond NH O NH Q3e OH 4251 CH O Q1o′ a bond Me a bond NH O NH T3a OH4252 CH O Q1o′ a bond Me a bond NH O NH T3b OH 4253 CH O Q1o′ a bond Mea bond NH O NH T3c OH 4254 CH O Q1o′ a bond Me a bond NH O NH T3d OH4255 CH O Q1o′ a bond Me a bond NH O NH T3e OH 4256 CH O Q1o′ a bond Mea bond NH O NH T3f OH 4257 CH O Q1o′ a bond Me a bond NH O NH T3g OH4258 CH O Q1o′ a bond Me a bond NH O NH T3h OH 4259 CH O Q1o′ a bond Mea bond NH O NH T3i OH 4260 CH O Q1o′ a bond Me a bond NH O NH T3j OH4261 CH O Q1o′ a bond Me a bond NH O a bond Q3a OH 4262 CH O Q1o′ a bondMe a bond NH O a bond Q3e OH 4263 CH O Q1o′ a bond Me a bond NH O a bondT3a OH 4264 CH O Q1o′ a bond Me a bond NH O a bond T3b OH 4265 CH O Q1o′a bond Me a bond NH O a bond T3c OH 4266 CH O Q1o′ a bond Me a bond NH Oa bond T3d OH 4267 CH O Q1o′ a bond Me a bond NH O a bond T3e OH 4268 CHO Q1o′ a bond Me a bond NH O a bond T3f OH 4269 CH O Q1o′ a bond Me abond NH O a bond T3g OH 4270 CH O Q1o′ a bond Me a bond NH O a bond T3hOH 4271 CH O Q1o′ a bond Me a bond NH O a bond T3i OH 4272 CH O Q1o′ abond Me a bond NH O a bond T3j OH 4273 CH O Q1o′ a bond H a bond NH S NHQ3a OH 4274 CH O Q1o′ a bond H a bond NH S NH Q3e OH 4275 CH O Q1o′ abond H a bond NH S NH T3a OH 4276 CH O Q1o′ a bond H a bond NH S NH T3bOH 4277 CH O Q1o′ a bond H a bond NH S NH T3c OH 4278 CH O Q1o′ a bond Ha bond NH S NH T3d OH 4279 CH O Q1o′ a bond H a bond NH S NH T3e OH 4280CH O Q1o′ a bond H a bond NH S NH T3f OH 4281 CH O Q1o′ a bond H a bondNH S NH T3g OH 4282 CH O Q1o′ a bond H a bond NH S NH T3h OH 4283 CH OQ1o′ a bond H a bond NH S NH T3i OH 4284 CH O Q1o′ a bond H a bond NH SNH T3j OH 4285 CH O Q1o′ a bond H a bond NH S a bond Q3a OH 4286 CH OQ1o′ a bond H a bond NH S a bond Q3e OH 4287 CH O Q1o′ a bond H a bondNH S a bond T3a OH 4288 CH O Q1o′ a bond H a bond NH S a bond T3b OH4289 CH O Q1o′ a bond H a bond NH S a bond T3c OH 4290 CH O Q1o′ a bondH a bond NH S a bond T3d OH 4291 CH O Q1o′ a bond H a bond NH S a bondT3e OH 4292 CH O Q1o′ a bond H a bond NH S a bond T3f OH 4293 CH O Q1o′a bond H a bond NH S a bond T3g OH 4294 CH O Q1o′ a bond H a bond NH S abond T3h OH 4295 CH O Q1o′ a bond H a bond NH S a bond T3i OH 4296 CH OQ1o′ a bond H a bond NH S a bond T3j OH 4297 CH O Q1o′ a bond H a bondNH O NH Q3a OH 4298 CH O Q1o′ a bond H a bond NH O NH Q3e OH 4299 CH OQ1o′ a bond H a bond NH O NH T3a OH 4300 CH O Q1o′ a bond H a bond NH ONH T3b OH 4301 CH O Q1o′ a bond H a bond NH O NH T3c OH 4302 CH O Q1o′ abond H a bond NH O NH T3d OH 4303 CH O Q1o′ a bond H a bond NH O NH T3eOH 4304 CH O Q1o′ a bond H a bond NH O NH T3f OH 4305 CH O Q1o′ a bond Ha bond NH O NH T3g OH 4306 CH O Q1o′ a bond H a bond NH O NH T3h OH 4307CH O Q1o′ a bond H a bond NH O NH T3i OH 4308 CH O Q1o′ a bond H a bondNH O NH T3j OH 4309 CH O Q1o′ a bond H a bond NH O a bond Q3a OH 4310 CHO Q1o′ a bond H a bond NH O a bond Q3e OH 4311 CH O Q1o′ a bond H a bondNH O a bond T3a OH 4312 CH O Q1o′ a bond H a bond NH O a bond T3b OH4313 CH O Q1o′ a bond H a bond NH O a bond T3c OH 4314 CH O Q1o′ a bondH a bond NH O a bond T3d OH 4315 CH O Q1o′ a bond H a bond NH O a bondT3e OH 4316 CH O Q1o′ a bond H a bond NH O a bond T3f OH 4317 CH O Q1o′a bond H a bond NH O a bond T3g OH 4318 CH O Q1o′ a bond H a bond NH O abond T3h OH 4319 CH O Q1o′ a bond H a bond NH O a bond T3i OH 4320 CH OQ1o′ a bond H a bond NH O a bond T3j OH 4321 CMe NMe Q1o′ a bond Me abond NH S NH Q3a OH 4322 CMe NMe Q1o′ a bond Me a bond NH S NH Q3e OH4323 CMe NMe Q1o′ a bond Me a bond NH S NH T3a OH 4324 CMe NMe Q1o′ abond Me a bond NH S NH T3b OH 4325 CMe NMe Q1o′ a bond Me a bond NH S NHT3c OH 4326 CMe NMe Q1o′ a bond Me a bond NH S NH T3d OH 4327 CMe NMeQ1o′ a bond Me a bond NH S NH T3e OH 4328 CMe NMe Q1o′ a bond Me a bondNH S NH T3f OH 4329 CMe NMe Q1o′ a bond Me a bond NH S NH T3g OH 4330CMe NMe Q1o′ a bond Me a bond NH S NH T3h OH 4331 CMe NMe Q1o′ a bond Mea bond NH S NH T3i OH 4332 CMe NMe Q1o′ a bond Me a bond NH S NH T3j OH4333 CMe NMe Q1o′ a bond Me a bond NH S a bond Q3a OH 4334 CMe NMe Q1o′a bond Me a bond NH S a bond Q3e OH 4335 CMe NMe Q1o′ a bond Me a bondNH S a bond T3a OH 4336 CMe NMe Q1o′ a bond Me a bond NH S a bond T3b OH4337 CMe NMe Q1o′ a bond Me a bond NH S a bond T3c OH 4338 CMe NMe Q1o′a bond Me a bond NH S a bond T3d OH 4339 CMe NMe Q1o′ a bond Me a bondNH S a bond T3e OH 4340 CMe NMe Q1o′ a bond Me a bond NH S a bond T3f OH4341 CMe NMe Q1o′ a bond Me a bond NH S a bond T3g OH 4342 CMe NMe Q1o′a bond Me a bond NH S a bond T3h OH 4343 CMe NMe Q1o′ a bond Me a bondNH S a bond T3i OH 4344 CMe NMe Q1o′ a bond Me a bond NH S a bond T3j OH4345 CMe NMe Q1o′ a bond Me a bond NH O NH Q3a OH 4346 CMe NMe Q1o′ abond Me a bond NH O NH Q3e OH 4347 CMe NMe Q1o′ a bond Me a bond NH O NHT3a OH 4348 CMe NMe Q1o′ a bond Me a bond NH O NH T3b OH 4349 CMe NMeQ1o′ a bond Me a bond NH O NH T3c OH 4350 CMe NMe Q1o′ a bond Me a bondNH O NH T3d OH 4351 CMe NMe Q1o′ a bond Me a bond NH O NH T3e OH 4352CMe NMe Q1o′ a bond Me a bond NH O NH T3f OH 4353 CMe NMe Q1o′ a bond Mea bond NH O NH T3g OH 4354 CMe NMe Q1o′ a bond Me a bond NH O NH T3h OH4355 CMe NMe Q1o′ a bond Me a bond NH O NH T3i OH 4356 CMe NMe Q1o′ abond Me a bond NH O NH T3j OH 4357 CMe NMe Q1o′ a bond Me a bond NH O abond Q3a OH 4358 CMe NMe Q1o′ a bond Me a bond NH O a bond Q3e OH 4359CMe NMe Q1o′ a bond Me a bond NH O a bond T3a OH 4360 CMe NMe Q1o′ abond Me a bond NH O a bond T3b OH 4361 CMe NMe Q1o′ a bond Me a bond NHO a bond T3c OH 4362 CMe NMe Q1o′ a bond Me a bond NH O a bond T3d OH4363 CMe NMe Q1o′ a bond Me a bond NH O a bond T3e OH 4364 CMe NMe Q1o′a bond Me a bond NH O a bond T3f OH 4365 CMe NMe Q1o′ a bond Me a bondNH O a bond T3g OH 4366 CMe NMe Q1o′ a bond Me a bond NH O a bond T3h OH4367 CMe NMe Q1o′ a bond Me a bond NH O a bond T3i OH 4368 CMe NMe Q1o′a bond Me a bond NH O a bond T3j OH 4369 CMe NMe Q1o′ a bond H a bond NHS NH Q3a OH 4370 CMe NMe Q1o′ a bond H a bond NH S NH Q3e OH 4371 CMeNMe Q1o′ a bond H a bond NH S NH T3a OH 4372 CMe NMe Q1o′ a bond H abond NH S NH T3b OH 4373 CMe NMe Q1o′ a bond H a bond NH S NH T3c OH4374 CMe NMe Q1o′ a bond H a bond NH S NH T3d OH 4375 CMe NMe Q1o′ abond H a bond NH S NH T3e OH 4376 CMe NMe Q1o′ a bond H a bond NH S NHT3f OH 4377 CMe NMe Q1o′ a bond H a bond NH S NH T3g OH 4378 CMe NMeQ1o′ a bond H a bond NH S NH T3h OH 4379 CMe NMe Q1o′ a bond H a bond NHS NH T3i OH 4380 CMe NMe Q1o′ a bond H a bond NH S NH T3j OH 4381 CMeNMe Q1o′ a bond H a bond NH S a bond Q3a OH 4382 CMe NMe Q1o′ a bond H abond NH S a bond Q3e OH 4383 CMe NMe Q1o′ a bond H a bond NH S a bondT3a OH 4384 CMe NMe Q1o′ a bond H a bond NH S a bond T3b OH 4385 CMe NMeQ1o′ a bond H a bond NH S a bond T3c OH 4386 CMe NMe Q1o′ a bond H abond NH S a bond T3d OH 4387 CMe NMe Q1o′ a bond H a bond NH S a bondT3e OH 4388 CMe NMe Q1o′ a bond H a bond NH S a bond T3f OH 4389 CMe NMeQ1o′ a bond H a bond NH S a bond T3g OH 4390 CMe NMe Q1o′ a bond H abond NH S a bond T3h OH 4391 CMe NMe Q1o′ a bond H a bond NH S a bondT3i OH 4392 CMe NMe Q1o′ a bond H a bond NH S a bond T3j OH 4393 CMe NMeQ1o′ a bond H a bond NH O NH Q3a OH 4394 CMe NMe Q1o′ a bond H a bond NHO NH Q3e OH 4395 CMe NMe Q1o′ a bond H a bond NH O NH T3a OH 4396 CMeNMe Q1o′ a bond H a bond NH O NH T3b OH 4397 CMe NMe Q1o′ a bond H abond NH O NH T3c OH 4398 CMe NMe Q1o′ a bond H a bond NH O NH T3d OH4399 CMe NMe Q1o′ a bond H a bond NH O NH T3e OH 4400 CMe NMe Q1o′ abond H a bond NH O NH T3f OH 4401 CMe NMe Q1o′ a bond H a bond NH O NHT3g OH 4402 CMe NMe Q1o′ a bond H a bond NH O NH T3h OH 4403 CMe NMeQ1o′ a bond H a bond NH O NH T3i OH 4404 CMe NMe Q1o′ a bond H a bond NHO NH T3j OH 4405 CMe NMe Q1o′ a bond H a bond NH O a bond Q3a OH 4406CMe NMe Q1o′ a bond H a bond NH O a bond Q3e OH 4407 CMe NMe Q1o′ a bondH a bond NH O a bond T3a OH 4408 CMe NMe Q1o′ a bond H a bond NH O abond T3b OH 4409 CMe NMe Q1o′ a bond H a bond NH O a bond T3c OH 4410CMe NMe Q1o′ a bond H a bond NH O a bond T3d OH 4411 CMe NMe Q1o′ a bondH a bond NH O a bond T3e OH 4412 CMe NMe Q1o′ a bond H a bond NH O abond T3f OH 4413 CMe NMe Q1o′ a bond H a bond NH O a bond T3g OH 4414CMe NMe Q1o′ a bond H a bond NH O a bond T3h OH 4415 CMe NMe Q1o′ a bondH a bond NH O a bond T3i OH 4416 CMe NMe Q1o′ a bond H a bond NH O abond T3j OH 4417 CMe S Q1o′ a bond Me a bond NH S NH Q3a OH 4418 CMe SQ1o′ a bond Me a bond NH S NH Q3e OH 4419 CMe S Q1o′ a bond Me a bond NHS NH T3a OH 4420 CMe S Q1o′ a bond Me a bond NH S NH T3b OH 4421 CMe SQ1o′ a bond Me a bond NH S NH T3c OH 4422 CMe S Q1o′ a bond Me a bond NHS NH T3d OH 4423 CMe S Q1o′ a bond Me a bond NH S NH T3e OH 4424 CMe SQ1o′ a bond Me a bond NH S NH T3f OH 4425 CMe S Q1o′ a bond Me a bond NHS NH T3g OH 4426 CMe S Q1o′ a bond Me a bond NH S NH T3h OH 4427 CMe SQ1o′ a bond Me a bond NH S NH T3i OH 4428 CMe S Q1o′ a bond Me a bond NHS NH T3j OH 4429 CMe S Q1o′ a bond Me a bond NH S a bond Q3a OH 4430 CMeS Q1o′ a bond Me a bond NH S a bond Q3e OH 4431 CMe S Q1o′ a bond Me abond NH S a bond T3a OH 4432 CMe S Q1o′ a bond Me a bond NH S a bond T3bOH 4433 CMe S Q1o′ a bond Me a bond NH S a bond T3c OH 4434 CMe S Q1o′ abond Me a bond NH S a bond T3d OH 4435 CMe S Q1o′ a bond Me a bond NH Sa bond T3e OH 4436 CMe S Q1o′ a bond Me a bond NH S a bond T3f OH 4437CMe S Q1o′ a bond Me a bond NH S a bond T3g OH 4438 CMe S Q1o′ a bond Mea bond NH S a bond T3h OH 4439 CMe S Q1o′ a bond Me a bond NH S a bondT3i OH 4440 CMe S Q1o′ a bond Me a bond NH S a bond T3j OH 4441 CMe SQ1o′ a bond Me a bond NH O NH Q3a OH 4442 CMe S Q1o′ a bond Me a bond NHO NH Q3e OH 4443 CMe S Q1o′ a bond Me a bond NH O NH T3a OH 4444 CMe SQ1o′ a bond Me a bond NH O NH T3b OH 4445 CMe S Q1o′ a bond Me a bond NHO NH T3c OH 4446 CMe S Q1o′ a bond Me a bond NH O NH T3d OH 4447 CMe SQ1o′ a bond Me a bond NH O NH T3e OH 4448 CMe S Q1o′ a bond Me a bond NHO NH T3f OH 4449 CMe S Q1o′ a bond Me a bond NH O NH T3g OH 4450 CMe SQ1o′ a bond Me a bond NH O NH T3h OH 4451 CMe S Q1o′ a bond Me a bond NHO NH T3i OH 4452 CMe S Q1o′ a bond Me a bond NH O NH T3j OH 4453 CMe SQ1o′ a bond Me a bond NH O a bond Q3a OH 4454 CMe S Q1o′ a bond Me abond NH O a bond Q3e OH 4455 CMe S Q1o′ a bond Me a bond NH O a bond T3aOH 4456 CMe S Q1o′ a bond Me a bond NH O a bond T3b OH 4457 CMe S Q1o′ abond Me a bond NH O a bond T3c OH 4458 CMe S Q1o′ a bond Me a bond NH Oa bond T3d OH 4459 CMe S Q1o′ a bond Me a bond NH O a bond T3e OH 4460CMe S Q1o′ a bond Me a bond NH O a bond T3f OH 4461 CMe S Q1o′ a bond Mea bond NH O a bond T3g OH 4462 CMe S Q1o′ a bond Me a bond NH O a bondT3h OH 4463 CMe S Q1o′ a bond Me a bond NH O a bond T3i OH 4464 CMe SQ1o′ a bond Me a bond NH O a bond T3j OH 4465 CMe S Q1o′ a bond H a bondNH S NH Q3a OH 4466 CMe S Q1o′ a bond H a bond NH S NH Q3e OH 4467 CMe SQ1o′ a bond H a bond NH S NH T3a OH 4468 CMe S Q1o′ a bond H a bond NH SNH T3b OH 4469 CMe S Q1o′ a bond H a bond NH S NH T3c OH 4470 CMe S Q1o′a bond H a bond NH S NH T3d OH 4471 CMe S Q1o′ a bond H a bond NH S NHT3e OH 4472 CMe S Q1o′ a bond H a bond NH S NH T3f OH 4473 CMe S Q1o′ abond H a bond NH S NH T3g OH 4474 CMe S Q1o′ a bond H a bond NH S NH T3hOH 4475 CMe S Q1o′ a bond H a bond NH S NH T3i OH 4476 CMe S Q1o′ a bondH a bond NH S NH T3j OH 4477 CMe S Q1o′ a bond H a bond NH S a bond Q3aOH 4478 CMe S Q1o′ a bond H a bond NH S a bond Q3e OH 4479 CMe S Q1o′ abond H a bond NH S a bond T3a OH 4480 CMe S Q1o′ a bond H a bond NH S abond T3b OH 4481 CMe S Q1o′ a bond H a bond NH S a bond T3c OH 4482 CMeS Q1o′ a bond H a bond NH S a bond T3d OH 4483 CMe S Q1o′ a bond H abond NH S a bond T3e OH 4484 CMe S Q1o′ a bond H a bond NH S a bond T3fOH 4485 CMe S Q1o′ a bond H a bond NH S a bond T3g OH 4486 CMe S Q1o′ abond H a bond NH S a bond T3h OH 4487 CMe S Q1o′ a bond H a bond NH S abond T3i OH 4488 CMe S Q1o′ a bond H a bond NH S a bond T3j OH 4489 CMeS Q1o′ a bond H a bond NH O NH Q3a OH 4490 CMe S Q1o′ a bond H a bond NHO NH Q3e OH 4491 CMe S Q1o′ a bond H a bond NH O NH T3a OH 4492 CMe SQ1o′ a bond H a bond NH O NH T3b OH 4493 CMe S Q1o′ a bond H a bond NH ONH T3c OH 4494 CMe S Q1o′ a bond H a bond NH O NH T3d OH 4495 CMe S Q1o′a bond H a bond NH O NH T3e OH 4496 CMe S Q1o′ a bond H a bond NH O NHT3f OH 4497 CMe S Q1o′ a bond H a bond NH O NH T3g OH 4498 CMe S Q1o′ abond H a bond NH O NH T3h OH 4499 CMe S Q1o′ a bond H a bond NH O NH T3iOH 4500 CMe S Q1o′ a bond H a bond NH O NH T3j OH 4501 CMe S Q1o′ a bondH a bond NH O a bond Q3a OH 4502 CMe S Q1o′ a bond H a bond NH O a bondQ3e OH 4503 CMe S Q1o′ a bond H a bond NH O a bond T3a OH 4504 CMe SQ1o′ a bond H a bond NH O a bond T3b OH 4505 CMe S Q1o′ a bond H a bondNH O a bond T3c OH 4506 CMe S Q1o′ a bond H a bond NH O a bond T3d OH4507 CMe S Q1o′ a bond H a bond NH O a bond T3e OH 4508 CMe S Q1o′ abond H a bond NH O a bond T3f OH 4509 CMe S Q1o′ a bond H a bond NH O abond T3g OH 4510 CMe S Q1o′ a bond H a bond NH O a bond T3h OH 4511 CMeS Q1o′ a bond H a bond NH O a bond T3i OH 4512 CMe S Q1o′ a bond H abond NH O a bond T3j OH 4513 CMe O Q1o′ a bond Me a bond NH S NH Q3a OH4514 CMe O Q1o′ a bond Me a bond NH S NH Q3e OH 4515 CMe O Q1o′ a bondMe a bond NH S NH T3a OH 4516 CMe O Q1o′ a bond Me a bond NH S NH T3b OH4517 CMe O Q1o′ a bond Me a bond NH S NH T3c OH 4518 CMe O Q1o′ a bondMe a bond NH S NH T3d OH 4519 CMe O Q1o′ a bond Me a bond NH S NH T3e OH4520 CMe O Q1o′ a bond Me a bond NH S NH T3f OH 4521 CMe O Q1o′ a bondMe a bond NH S NH T3g OH 4522 CMe O Q1o′ a bond Me a bond NH S NH T3h OH4523 CMe O Q1o′ a bond Me a bond NH S NH T3i OH 4524 CMe O Q1o′ a bondMe a bond NH S NH T3j OH 4525 CMe O Q1o′ a bond Me a bond NH S a bondQ3a OH 4526 CMe O Q1o′ a bond Me a bond NH S a bond Q3e OH 4527 CMe OQ1o′ a bond Me a bond NH S a bond T3a OH 4528 CMe O Q1o′ a bond Me abond NH S a bond T3b OH 4529 CMe O Q1o′ a bond Me a bond NH S a bond T3cOH 4530 CMe O Q1o′ a bond Me a bond NH S a bond T3d OH 4531 CMe O Q1o′ abond Me a bond NH S a bond T3e OH 4532 CMe O Q1o′ a bond Me a bond NH Sa bond T3f OH 4533 CMe O Q1o′ a bond Me a bond NH S a bond T3g OH 4534CMe O Q1o′ a bond Me a bond NH S a bond T3h OH 4535 CMe O Q1o′ a bond Mea bond NH S a bond T3i OH 4536 CMe O Q1o′ a bond Me a bond NH S a bondT3j OH 4537 CMe O Q1o′ a bond Me a bond NH O NH Q3a OH 4538 CMe O Q1o′ abond Me a bond NH O NH Q3e OH 4539 CMe O Q1o′ a bond Me a bond NH O NHT3a OH 4540 CMe O Q1o′ a bond Me a bond NH O NH T3b OH 4541 CMe O Q1o′ abond Me a bond NH O NH T3c OH 4542 CMe O Q1o′ a bond Me a bond NH O NHT3d OH 4543 CMe O Q1o′ a bond Me a bond NH O NH T3e OH 4544 CMe O Q1o′ abond Me a bond NH O NH T3f OH 4545 CMe O Q1o′ a bond Me a bond NH O NHT3g OH 4546 CMe O Q1o′ a bond Me a bond NH O NH T3h OH 4547 CMe O Q1o′ abond Me a bond NH O NH T3i OH 4548 CMe O Q1o′ a bond Me a bond NH O NHT3j OH 4549 CMe O Q1o′ a bond Me a bond NH O a bond Q3a OH 4550 CMe OQ1o′ a bond Me a bond NH O a bond Q3e OH 4551 CMe O Q1o′ a bond Me abond NH O a bond T3a OH 4552 CMe O Q1o′ a bond Me a bond NH O a bond T3bOH 4553 CMe O Q1o′ a bond Me a bond NH O a bond T3c OH 4554 CMe O Q1o′ abond Me a bond NH O a bond T3d OH 4555 CMe O Q1o′ a bond Me a bond NH Oa bond T3e OH 4556 CMe O Q1o′ a bond Me a bond NH O a bond T3f OH 4557CMe O Q1o′ a bond Me a bond NH O a bond T3g OH 4558 CMe O Q1o′ a bond Mea bond NH O a bond T3h OH 4559 CMe O Q1o′ a bond Me a bond NH O a bondT3i OH 4560 CMe O Q1o′ a bond Me a bond NH O a bond T3j OH 4561 CMe OQ1o′ a bond H a bond NH S NH Q3a OH 4562 CMe O Q1o′ a bond H a bond NH SNH Q3e OH 4563 CMe O Q1o′ a bond H a bond NH S NH T3a OH 4564 CMe O Q1o′a bond H a bond NH S NH T3b OH 4565 CMe O Q1o′ a bond H a bond NH S NHT3c OH 4566 CMe O Q1o′ a bond H a bond NH S NH T3d OH 4567 CMe O Q1o′ abond H a bond NH S NH T3e OH 4568 CMe O Q1o′ a bond H a bond NH S NH T3fOH 4569 CMe O Q1o′ a bond H a bond NH S NH T3g OH 4570 CMe O Q1o′ a bondH a bond NH S NH T3h OH 4571 CMe O Q1o′ a bond H a bond NH S NH T3i OH4572 CMe O Q1o′ a bond H a bond NH S NH T3j OH 4573 CMe O Q1o′ a bond Ha bond NH S a bond Q3a OH 4574 CMe O Q1o′ a bond H a bond NH S a bondQ3e OH 4575 CMe O Q1o′ a bond H a bond NH S a bond T3a OH 4576 CMe OQ1o′ a bond H a bond NH S a bond T3b OH 4577 CMe O Q1o′ a bond H a bondNH S a bond T3c OH 4578 CMe O Q1o′ a bond H a bond NH S a bond T3d OH4579 CMe O Q1o′ a bond H a bond NH S a bond T3e OH 4580 CMe O Q1o′ abond H a bond NH S a bond T3f OH 4581 CMe O Q1o′ a bond H a bond NH S abond T3g OH 4582 CMe O Q1o′ a bond H a bond NH S a bond T3h OH 4583 CMeO Q1o′ a bond H a bond NH S a bond T3i OH 4584 CMe O Q1o′ a bond H abond NH S a bond T3j OH 4585 CMe O Q1o′ a bond H a bond NH O NH Q3a OH4586 CMe O Q1o′ a bond H a bond NH O NH Q3e OH 4587 CMe O Q1o′ a bond Ha bond NH O NH T3a OH 4588 CMe O Q1o′ a bond H a bond NH O NH T3b OH4589 CMe O Q1o′ a bond H a bond NH O NH T3c OH 4590 CMe O Q1o′ a bond Ha bond NH O NH T3d OH 4591 CMe O Q1o′ a bond H a bond NH O NH T3e OH4592 CMe O Q1o′ a bond H a bond NH O NH T3f OH 4593 CMe O Q1o′ a bond Ha bond NH O NH T3g OH 4594 CMe O Q1o′ a bond H a bond NH O NH T3h OH4595 CMe O Q1o′ a bond H a bond NH O NH T3i OH 4596 CMe O Q1o′ a bond Ha bond NH O NH T3j OH 4597 CMe O Q1o′ a bond H a bond NH O a bond Q3a OH4598 CMe O Q1o′ a bond H a bond NH O a bond Q3e OH 4599 CMe O Q1o′ abond H a bond NH O a bond T3a OH 4600 CMe O Q1o′ a bond H a bond NH O abond T3b OH 4601 CMe O Q1o′ a bond H a bond NH O a bond T3c OH 4602 CMeO Q1o′ a bond H a bond NH O a bond T3d OH 4603 CMe O Q1o′ a bond H abond NH O a bond T3e OH 4604 CMe O Q1o′ a bond H a bond NH O a bond T3fOH 4605 CMe O Q1o′ a bond H a bond NH O a bond T3g OH 4606 CMe O Q1o′ abond H a bond NH O a bond T3h OH 4607 CMe O Q1o′ a bond H a bond NH O abond T3i OH 4608 CMe O Q1o′ a bond H a bond NH O a bond T3j OH

74) The compounds in Table 6 wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³and X are any of the following combinations in Table 6, tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof (provided that in the case of 74), Q1a, Q1b, Q1c, Q1i,Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3jin Table 6 denote the following substituents).

75) The compounds in Table 6 wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³and X are any of the following combinations in Table 6, tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof (provided that in the case of 75), Q1a, Q1b, Q1c, Q1i,Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3jin Table 6 denote the following substituents).

76) The compounds in Table 6 wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³and X are any of the following combinations in Table 6, tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof (provided that in the case of 76), Q1a, Q1b, Q1c, Q1i,Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3jin Table 6 denote the following substituents).

77) The compounds in Table 6 wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³and X are any of the following combinations in Table 6, tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof (provided that in the case of 77), Q1a, Q1b, Q1c, Q1i,Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3jin Table 6 denote the following substituents).

78) The compounds in Table 6 wherein A, B, L¹, R², L², L³, Y, L⁴, R³ andX are any of the following combinations in Table 6, tautomers, prodrugsor pharmaceutically acceptable salts of the compounds or solvatesthereof (provided that in the case of 78), Q1a, Q1b, Q1c, Q1i, Q1j,Q1o′, Q3a, T1a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j inTable 6 denote the following substituents).

79) The compounds in Table 6 wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³and X are any of the following combinations in Table 6, tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof (provided that in the case of 79), Q1a, Q1b, Q1c, Q1i,Q1j, Q1o′, Q3a, T1a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3jin Table 6 denote the following substituents).

80) The compounds in Table 6 wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³and X are any of the following combinations in Table 6, tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof (provided that in the case of 80), Q1a, Q1b, Q1c, Q1i,Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3jin Table 6 denote the following substituents).

81) The compounds in Table 6 wherein A, B, L¹, R², L², L³, Y, L⁴, R³ andX are any of the following combinations in Table 6, tautomers, prodrugsor pharmaceutically acceptable salts of the compounds or solvatesthereof (provided that in the case of 81), Q1a, Q1b, Q1c, Q1i, Q1j,Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j inTable 6 denote the following substituents).

82) The compounds in Table 6 wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³and X are any of the following combinations in Table 6, tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof (provided that in the case of 82), Q1a, Q1b, Q1c, Q1i,Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3jin Table 6 denote the following substituents).

83) The compounds in Table 6 wherein A, B, R¹, L¹, R², L², L³, Y, L⁴, R³and X are any of the following combinations in Table 6, tautomers,prodrugs or pharmaceutically acceptable salts of the compounds orsolvates thereof (provided that in the case of 83), Q1a, Q1b, Q1c, Q1i,Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3jin Table 6 denote the following substituents).

84) The compound represented by any of 68) to 83) wherein X is convertedto SH, tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

85) The compound represented by any of 68) to 83) wherein X is convertedto NH₂, tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

86) The compound represented by any of 68) to 83) wherein X is convertedto OAc, tautomers, prodrugs or pharmaceutically acceptable salts of thecompounds or solvates thereof.

87) The thrombopoietin receptor activators represented by any of 1) to86).

88) Preventive, therapeutic and improving agents for diseases againstwhich activation of the thrombopoietin receptor is effective whichcontain the thrombopoietin receptor activators represented by 87) or theformula (1), tautomers, prodrugs or pharmaceutically acceptable salts ofthe activators or solvates thereof, as an active ingredient.

89) Platelet increasing agents containing the thrombopoietin receptoractivators represented by 87) or the formula (1), tautomers, prodrugs orpharmaceutically acceptable salts of the activators or solvates thereof,as an active ingredient.

90) Medicaments containing the compounds represented by any of 1) to 86)or the formula (1), tautomers, prodrugs or pharmaceutically acceptablesalts of the compounds or solvates thereof, as an active ingredient.

In the present invention, the compounds of the present inventionrepresented by the formula (1) may be present in the form of tautomersor geometrical isomers which undergo endocyclic or exocyclicisomerization, mixtures of tautomers or geometric isomers or mixtures ofthereof. When the compounds of the present invention have an asymmetriccenter, whether or not resulting from an isomerization, the compounds ofthe present invention may be in the form of resolved optical isomers orin the form of mixtures containing them in certain ratios.

For example, furan compounds, thiophene compounds and pyrrole compoundsof the present invention may be present in the form of tetronic acid(4-hydroxy-2(5H)-furanone) analogues, thiotetronic acid(4-hydroxy-2(5H)-thiophenone) analogues and tetraminic acid(4-hydroxy-3-pyrrolin-2-one) analogues as shown below by the formulae(2), (3) and (4), mixtures thereof or mixtures of isomers thereof.

The compounds of the present invention represented by the formula (1) orpharmaceutically acceptable salts thereof may be in the form ofarbitrary crystals or arbitrary hydrates, depending on the productionconditions. The present invention covers these crystals, hydrates andmixtures. They may be in the form of solvates with organic solvents suchas acetone, ethanol and tetrahydrofuran, and the present inventioncovers any of these forms.

The compounds of the present invention represented by the formula (1)may be converted to pharmaceutically acceptable salts or may beliberated from the resulting salts, if necessary. The pharmaceuticallyacceptable salts of the present invention may be, for example, saltswith alkali metals (such as lithium, sodium and potassium), alkalineearth metals (such as magnesium and calcium), ammonium, organic basesand amino acids. They may be salts with inorganic acids (such ashydrochloric acid, hydrobromic acid, phosphoric acid and sulfuric acid)and organic acids (such as acetic acid, citric acid, maleic acid,fumaric acid, benzenesulfonic acid and p-toluenesulfonic acid).

The compounds which serve as prodrugs are derivatives of the presentinvention having chemically or metabolically degradable groups whichgive pharmacologically active compounds of the present invention uponsolvolysis or under physiological conditions in vivo. Methods forselecting or producing appropriate prodrugs are disclosed, for example,in Design of Prodrug (Elsevier, Amsterdam 1985). In the presentinvention, when the compound has a hydroxyl group, acyloxy derivativesobtained by reacting the compound with appropriate acyl halides orappropriate acid anhydrides may, for example, be mentioned as prodrugs.Acyloxys particularly preferred as prodrugs include —OCOC₂H₅,—OCO(t-Bu), —OCOC₁₅H₃₁, —OCO(m-CO₂Na-Ph), —OCOCH₂CH₂CO₂Na,—OCOCH(NH₂)CH₃, —OCOCH₂N(CH₃)₂ and the like. When the compound of thepresent invention has an amino group, amide derivatives obtained byreacting the compound having an amino group with appropriate acidhalides or appropriate mixed acid anhydrides may, for example, bementioned as prodrugs. Amides particularly preferred as prodrugs include—NHCO(CH₂)₂₀CH₃, —NHCOCH(NH₂)CH₃ and the like. When the compound of thepresent invention has a carboxyl group, carboxylic acid esters withaliphatic alcohols or carboxylic-acid esters obtained by the reactionwith an alcoholic free hydroxyl group of 1,2- or 1,3-digylcerides may,for example, be mentioned as prodrugs. Particularly preferred prodrugsare methyl esters and ethyl esters.

The preventive, therapeutic and improving agents for diseases againstwhich activation of the thrombopoietin receptor is effective or plateletincreasing agents which contain the thrombopoietin receptor activatorsof the present invention, tautomers, prodrugs or pharmaceuticallyacceptable salts of the activators or solvates thereof as an activeingredient may usually be administered as oral medicines such astablets, capsules, powder, granules, pills and syrup, as rectalmedicines, percutaneous medicines or injections. The agents of thepresent invention may be administered as a single therapeutic agent oras a mixture with other therapeutic agents. Though they may beadministered as they are, they are usually administered in the form ofmedical compositions. These pharmaceutical preparations can be obtainedby adding pharmacologically and pharmaceutically acceptable additives byconventional methods. Namely, for oral medicines, ordinary excipients,lubricants, binders, disintegrants, humectants, plasticizers and coatingagents may be used. Oral liquid preparations may be in the form ofaqueous or oily suspensions, solutions, emulsions, syrups or elixirs ormay be supplied as dry syrups to be mixed with water or otherappropriate solvents before use. Such liquid preparations may containordinary additives such as suspending agents, perfumes, diluents andemulsifiers. In the case of rectal administration, they may beadministered as suppositories. Suppositories may use an appropriatesubstance such as cacao butter, laurin tallow, Macrogol, glycerogelatin,Witepsol, sodium stearate and mixtures thereof as the base and may, ifnecessary, contain an emulsifier, a suspending agent, a preservative andthe like. For injections, pharmaceutical ingredients such as distilledwater for injection, physiological saline, 5% glucose solution,propylene glycol and other solvents or solubilizing agents, a pHregulator, an isotonizing agent and a stabilizer may be used to formaqueous dosage forms or dosage forms which need dissolution before use.

The dose of the agents of the present invention for administration tohuman is usually about from 0.1 to 1000 mg/human/day in the case of oraldrugs or rectal administration and about from 0.05 mg to 500mg/human/day in the case of injections, though it depends on the age andconditions of the patient. The above-mentioned ranges are mere examples,and the dose should be determined from the conditions of the patient.

The present invention is used when the use of compounds which havethrombopoietin receptor affinity and act as thrombopoietin receptoragonists are expected to improve pathological conditions. For example,hematological disorders accompanied by abnormal platelet count may bementioned. Specifically, it is effective for therapy or prevention ofhuman and mammalian diseases caused by abnormal megakaryopoiesis,especially those accompanied by thrombocytopenia. Examples of suchdiseases include thrombocytopenia accompanying chemotherapy orradiotherapy of cancer, thrombocytopenia accompanying antiviral therapyfor diseases such as hepatitis C, thrombocytopenia caused by bone marrowtransplantation, surgery and serious infections, or gastrointestinalbleeding, but such diseases are not restricted to those mentioned.Typical thrombocytopenias such as aplastic anemia, idiopathicthrombocytopenic purpura, myelodysplastic syndrome, hepatic disease, HIVinfection and thrombopoietin deficiency are also targets of the agentsof the present invention. The present invention may be used as aperipheral stem cell mobilizer, a megakaryoblastic or megakaryocyticleukemia cell differentiation inducer and a platelet increasing agentfor platelet donors. In addition, potential applications includetherapeutic angiogenesis based on differentiation and proliferation ofvascular endothelial cells and endothelial progenitor cells, preventionand therapy of arteriosclerosis, myocardial infarction, unstable angina,peripheral artery occlusive disease, but there is no restriction.

The compounds represented by the formula (1) are prepared by the processrepresented by the formula (5) illustrated below.

The reaction of the compound (I) with a —NH₂ compound (II) in a solvent,if necessary in the presence of a catalyst, under heating with stirringgives a desired compound or its precursor. The precursor may be, ifnecessary, hydrolyzed, deprotected, reduced or oxidized to a desiredcompound. The compounds of the present invention usually can be purifiedby column chromatography, thin layer chromatography, high performanceliquid chromatography (HPLC) or high performance liquidchromatography-mass spectrometry (LC-MS) and, if necessary, they may beobtained with high purity by recrystallization or washing with solvents.

For the syntheses of the intermediates (I), syntheses of the followingheterocyclic compounds may be referred to.

-   1) Pyrazole (the formula (6))-   J. Chem. Soc. Perkin. Transl, p. 81, (1985)-   2) Isothiazole (the formula (7))-   Liebigs. Annalen. der. Chemie., 10, 1534-1546 (1979)-   3) Isoxazole (the formula (8))-   Synthesis, 10, 664-665 (1975)-   4) Thiophene (the formula (9))-   JP-A-48-026755-   5) Furan (the formula (10))-   J. Org. Chem., 21, 1492-1509 (1956)-   6) Pyrrole (the formula (11))-   J. Heterocyclic Chem., 30, 1253 (1993) and Tetrahedron, 50(26),    7849-56 (1994)-   7) Tetronic acid (4-hydroxy-2(5H)-furanone) analogue (the formula    (12))-   Synthesis, 7, 564-566 (1988) and Yakugaku Zasshi, 96(4), 536-543    (1976)-   8) Tetraminic acid (4-hydroxy-3-pyrrolin-2-one) analogue (the    formula (13))-   Synthesis, 2, 190-192 (1987) and Agric. Biol. Chem., 43(8),    1641-1646 (1979)

For synthesis of the —NH₂ compounds (II), for example, when L³═NH, thefollowing may be referred to.

-   1) L⁴=a bond, Y═O-   Synthetic Commun., 28(7), 1223-1231 (1998), J. Chem. Soc.,    1225 (1948) and J. Chem. Soc., 2831 (1952)-   2) L⁴═NH, Y═O-   J. Am. Chem. Soc., 46, 2813 (1924) and J. Chem. Soc., 2654 (1952)-   3) L⁴═NH, Y═S-   Can. J. Chem., 35, 834 (1957)-   4) L⁴=CH₂, Y═O-   J. Org. Chem., 30, 2487 (1965)-   5) L⁴=0, Y═O-   Bull. Soc. Chim. Belg., 68, 409, (1959)

EXAMPLES

Now, the present invention will be described in further detail withreference to Reference Synthetic Examples, Synthetic Examples, AssayExamples and Formulation Examples. However, it should be understood thatthe present invention is by no means restricted by these specificExamples.

The ¹H-NMR analysis was carried out at 300 MHz.

In the REFERENCE SYNTHETIC EXAMPLE 59-75 and the SYNTHETIC EXAMPLE124-240, LC/MS was measured on the following conditions.

LC/MS condition 1

column: Waters SunFire C18 (3.5 μm, 4.6×30 mm)

elute: MeCN/0.1% aq. HCOOH (10/90 to 30/70)

LC/MS condition 2

column: Waters SunFire C18 (3.5 μm, 4.6×30 mm)

elute: MeCN/0.1% aq. HCOOH (10/90 to 60/40)

LC/MS condition 3

column: Waters SunFire C18 (3.5 μm, 4.6×30 mm)

elute: MeCN/0.1% aq. HCOOH (10/90 to 85/15)

LC/MS condition 4

column: Waters Xterra MSC18 (5 μm, 4.6×50 mm)

elute: MeCN/0.1% aq. HCOOH (10/90 to 30/70)

LC/MS condition 5

column: Waters Xterra MSC18 (5 μm, 4.6×50 mm)

elute: MeCN/0.1% aq. HCOOH (10/90 to 60/40)

LC/MS condition 6

column: Waters Xterra MSC18 (5 μm, 4.6×50 mm)

elute: MeCN/0.1% aq. HCOOH (10/90 to 85/15)

LC/MS condition 7

column: Waters Xterra MSC18 (5 μm, 4.6×50 mm)

elute: MeCN/0.1% aq. HCOOH (20/80 to 100/0)

LC/MS condition 8

column: Waters Xterra MSC18 (3.5 μm, 2.1×20 mm).

elute: MeCN/0.2% aq. HCOOH (20/80 to 90/10)

LC/MS condition 9

column: Waters SunFire C18 (3.5 μm, 4.6×30 mm)

elute: MeCN/0.1% aq. HCOOH (20/80 to 100/0)

Reference Synthetic Example 1 Synthesis of 2-oxopropanal methylhydrazone

A mixed solution of methylhydrazine (8.34 mL, 158.22 mmol) in aceticacid (15 mL) and water (60 mL) was added to 10% methylglyoxal aqueoussolution (92.5 mL, 151.21 mmol), and the mixture was stirred at roomtemperature for about 24 hours. The reaction solution was extracted withchloroform three times, and the extract was dried, filtered andconcentrated. Purification of the resulting black solution by vacuumdistillation gave the desired product as a yellow solid (5.357 g, yield35%).

¹H-NMR (ppm in CDCl₃)

δ 6.86 (s, 1H), 6.59 (br.s, 1H), 2.98 (d, J=4.2 Hz, 3H), 2.30 (s, 3H)

LC-MS (ESI) 100 (M⁺)

Reference Synthetic Example 2 Synthesis of 2-oxopropanal ethylhydrazone

Ethylhydrazine (8.46 mmol, 556 mg) was dissolved in methanol (4 mL), andthe reactor was cooled to 0° C. Methylglyoxal (40% in H₂O, 9.3 mmol,1.42 mL) was added, and the mixture was stirred for 15 minutes at thesame temperature and then for 2.5 hours at room temperature. Afteraddition of water, it was extracted with chloroform three times. Theresulting organic layer was dried over anhydrous magnesium sulfate andfiltered, and the solvent was evaporated with an evaporator. The residuewas dried by means of a vacuum pump to give the desired product as anorange liquid (0.955 g (crude), yield 99%).

¹H-NMR (ppm in CDCl₃)

δ 9.29 (s, 1H), 6.32 (br.s, 1H), 3.58 (q, J=7.1 Hz, 1H), 3.57 (q, J=7.1Hz, 1H), 1.79 (s, 3H), 1.29 (t, J=7.1 Hz, 3H)

Reference Synthetic Example 3 Synthesis of(3,4-dichlorophenyl)(oxo)acetaldehyde

3,4-dichloroacetophenone (5.39 mmol, 1.02 g) was dissolved in dimethylsulfoxide (13 mL), and 48% hydrobromic acid (1.83 mL) was graduallyadded at room temperature. The mixture was stirred overnight at 60° C.,and then the reactor was cooled to room temperature. The reactionsolution was poured into water (50 mL) at 0° C. and stirred for about 1hour. The precipitated solid was recovered by filtration, washed withwater and dried by means of a vacuum pump to give the desired product asa pale yellow solid (0.780 g, yield 71%).

¹H-NMR (ppm in DMSO-d₆)

δ 8.26 (d, J=2.0 Hz, 1H), 8.01 (dd, J=2.0, 8.6 Hz, 1H), 7.82 (d, J=8.6Hz, 1H), 7.01 (d, J=6.6 Hz, 2H, H₂O), 5.61 (br.s, 1H)

MS (EI) 173 (M⁺-CHO)

Reference Synthetic Example 4 Synthesis of(4-t-butylphenyl)(oxo)acetaldehyde

4-t-Butylacetophenone (100 mmol, 18.74 mL) was dissolved in dimethylsulfoxide (104 mL), then the reactor was cooled to 0° C., and 48%hydrobromic acid (34 mL) was gradually added. After 18 hours of stirringat 70° C., the reaction solution was poured into water (400 mL) andstirred for 24 hours. The precipitated yellow solid was recovered byfiltration, washed with n-hexane several times and dried by means of avacuum pump to give the desired product as a pale yellow solid (13.89 g,yield 73%).

¹H-NMR (ppm in DMSO-d₆)

δ 8.01 (ABq, J=8.4 Hz, 2H), 7.51 (ABq, J=8.4 Hz, 2H), 6.01 (s, 1H), 1.30(s, 9H)

LC-MS (ESI) 190 (M⁺)

Reference Synthetic Example 5 Synthesis of(3,4-dimethylphenyl)(oxo)acetaldehyde

3,4-dimethylacetophenone (13.52 mmol, 2.0 g) was dissolved in dimethylsulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually addedat room temperature. After 16 hours of stirring at 70° C., the reactorwas cooled to room temperature. The reaction solution was poured intowater and stirred for about 16 hours. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump to give the desired product as a white solid (1.234 g, yield57%).

¹H-NMR (ppm in DMSO-d₆)

δ 7.83-7.80 (multi, 2H), 7.33 (br.s, 2H, H₂O), 7.26 (d, J=7.5 Hz, 1H),5.96 (br.s, 1H), 2.28 (s, 3H), 2.22 (s, 3H)

Reference Synthetic Example 6 Synthesis of(4-n-pentylphenyl)(oxo)acetaldehyde

4-n-Pentylacetophenone (10.66 mmol, 2.028 g) was dissolved in dimethylsulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually addedat room temperature. After 9.5 hours of stirring at 70° C., the reactorwas cooled to room temperature. The reaction solution was poured intowater and stirred for about 16 hours. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump to give the desired product as a pale yellow solid (2.1784 g(crude), 100%).

¹H-NMR (ppm in DMSO-d₆)

δ 7.99 (ABq, J=8.3 Hz, 2H), 7.33 (ABq, J=8.3 Hz, 2H), 6.67 (br.s, 2H,H₂O), 5.67 (br.s, 1H), 2.69-2.61 (multi, 2H), 1.66-1.50 (multi, 2H),1.36-1.20 (multi, 4H), 0.88-0.83 (multi, 3H).

Reference Synthetic Example 7 Synthesis of(4-trifluoromethylphenyl)(oxo)acetaldehyde

4-Trifluoromethylacetophenone (11.14 mmol, 2.096 g) was dissolved indimethyl sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) wasgradually added at room temperature. After 9.5 hours of stirring at 70°C., the reactor was cooled to room temperature. The reaction solutionwas poured into water and stirred for about 16 hours. The precipitatedsolid was recovered by filtration, washed with water and dried by meansof a vacuum pump to give the desired product as a yellow solid (1.3116g, yield 59%).

¹H-NMR (ppm in DMSO-d₆)

δ 8.27 (ABq, J=8.3 Hz, 2H), 7.90 (ABq, J=8.3 Hz, 2H), 6.97 (br.s, 2H,H₂O), 5.68 (br.s, 1H)

Reference Synthetic Example 8 Synthesis ofoxo[3-(trifluoromethyl)phenyl]acetaldehyde

3-Trifluoromethylacetophenone (11.80 mmol, 2.22 g) was dissolved indimethyl sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) wasgradually added at room temperature. After overnight stirring at 70° C.,the reactor was cooled to room temperature. After addition of water, thereaction solution was extracted with chloroform, and the extract wasdried and filtered, and the solvent was evaporated to give the desiredproduct as a yellow liquid (3.04 g (crude), yield 128%).

Reference Synthetic Example 9 Synthesis of(3-bromo-4-fluorophenyl)(oxo)acetaldehyde

From 3-bromo-4-fluoroacetophenone, the desired product was obtained inthe same manner as in Reference Synthetic Example 8 as a yellow liquid(crude, yield 114%).

Reference Synthetic Example 10 Synthesis of(3,5-dimethylphenyl)(oxo)acetaldehyde

From 3,5-dimethylacetophenone, the desired product was obtained in thesame manner as in Reference Synthetic Example 8 as a yellow solid(crude, yield 104%).

Reference Synthetic Example 11 Synthesis of(4-ethylphenyl)(oxo)acetaldehyde

4-Ethylacetophenone (26.72 mmol, 4 mL) was dissolved in dimethylsulfoxide (27 mL), and 48% hydrobromic acid (11 mL) was gradually addedat room temperature. After overnight stirring at 70° C., the reactor wascooled to room temperature. The reaction solution was poured into water(50 mL) and stirred for about 1 hour. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump to give the desired product as a white solid (2.44 g, yield56%).

Reference Synthetic Example 12 Synthesis of(4-isopropylphenyl)(oxo)acetaldehyde

From 4-isopropylacetophenone, the desired product was obtained in thesame manner as in Reference Synthetic Example 8 as a yellow solid(crude, yield 103%).

Reference Synthetic Example 13 Synthesis ofoxo(4-n-propylphenyl)acetaldehyde

From 4-n-propylacetophenone, the desired product was obtained in thesame manner as in Reference Synthetic Example 11 as a yellow liquid(crude, yield 92%).

Reference Synthetic Example 14 Synthesis of(4-n-hexylphenyl)(oxo)acetaldehyde

From 4-n-hexylacetophenone, the desired product was obtained in the samemanner as in Reference Synthetic Example 11 as a yellow solid (crude,yield 131%).

Reference Synthetic Example 15 Synthesis of(4-isobutylphenyl)(oxo)acetaldehyde

From 4-isobutylacetophenone, the desired product was obtained in thesame manner as in Reference Synthetic Example 8 as a yellow liquid(crude, yield 108%).

Reference Synthetic Example 16 Synthesis of2-(4-t-butylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene

60% Sodium hydride (28 mg, 0.69 mmol) was added to a solution of2-(4-t-butylphenyl)-3-hydroxy-4-ethoxycarbonylthiophene (0.20 g, 0.66mmol) obtained in accordance with JP-A-48-26755 in dimethylformamide(1.0 mL) at room temperature, and the reaction solution was stirred at60° C. for 15 minutes. After the reaction solution was cooled to roomtemperature, chloromethyl methyl ether (0.055 mL, 0.73 mmol) was addeddropwise, and the reaction solution was stirred at room temperature foranother 5 hours. After addition of saturated aqueous ammonium chloride,the reaction solution was extracted with ethyl acetate, and the organiclayer was washed with saturated aqueous sodium chloride, dried overanhydrous sodium sulfate. The organic layer was concentrated andpurified by silica gel column chromatography (chloroform) to give thedesired product as a colorless oil (212 mg, yield 91%).

¹H-NMR (ppm in CDCl₃)

δ 1.34 (s, 9H), 1.38 (t, J=7.2 Hz, 3H), 3.23 (s, 3H), 4.34 (q, J=7.2 Hz,2H), 5.00 (s, 2H), 7.41-7.44 (m, 2H), 7.60-7.63 (m, 2H), 7.97 (s, 1H).

LC/MS (ES⁺) 371 (Na⁺ adduct).

Reference Synthetic Example 17 Synthesis of2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene

From 2-(3,4-dichlorophenyl)-3-hydroxy-4-ethoxycarbonylthiophene (7.7 g,24 mmol), the desired product was obtained in the same manner as inReference Synthetic Example 16 as a colorless oil (5.4 g, yield 62%).

¹H-NMR (ppm in CDCl₃)

δ 1.38 (t, J=7.2 Hz, 3H), 3.27 (s, 3H), 4.34 (q, J=7.2 Hz, 2H), 5.06 (s,2H), 7.46-7.54 (m, 2H), 7.86 (d, J=1.9 Hz, 1H), 8.04 (s, 1H).

Reference Synthetic Example 18 Synthesis of2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene

From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-ethoxycarbonylthiophene(1.6 g, 5.2 mmol), the desired product was obtained in the same manneras in Reference Synthetic Example 16 as a brown oil (1.8 g, yield 95%).

¹H-NMR (ppm in CDCl₃)

δ 1.39 (t, J=7.2 Hz, 3H), 3.21 (s, 3H), 4.35 (q, J=7.2 Hz, 2H), 5.05 (s,2H), 7.67 (d, J=8.3 Hz, 2H), 7.83 (d, J=8.3 Hz, 2H), 8.07 (s, 1H).

Reference Synthetic Example 19 Synthesis of2-(4-t-butylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene

To lithium aluminium hydride (27 mg, 0.72 mmol) in THF (0.86 mL),2-(4-t-butylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene (0.21g, 0.60 mmol) in THF (0.86 mL) was added dropwise under cooling withice, and the reaction solution was stirred under cooling with ice for 1hour. After addition of saturated aqueous ammonium chloride, thereaction solution was extracted with ethyl acetate, and the organiclayer was washed with saturated aqueous sodium chloride, dried overanhydrous sodium sulfate, concentrated and purified by silica gel columnchromatography (n-hexane/ethyl acetate=3/1) to give the desired productas a colorless oil (87 mg, yield 47%).

¹H-NMR (ppm in CDCl₃)

δ 1.25 (s, 9H), 3.05 (bs, 1H), 3.40 (s, 3H), 4.46 (d, J=5.8 Hz, 2H),4.81 (s, 2H), 7.02 (s, 1H), 7.30-7.34 (m, 2H), 7.47-7.50 (m, 2H).

LC/MS (ES⁺) 329 (Na⁺ adduct).

Reference Synthetic Example 20 Synthesis of2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene

From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene(5.0 g, 14 mmol), the desired product was obtained in the same manner asin Reference Synthetic Example 19 as a colorless oil (4.3 g, 98%).

¹H-NMR (ppm in CDCl₃)

δ 3.51 (s, 3H), 4.56 (d, J=5.8 Hz, 2H), 4.91 (s, 2H), 7.21 (s, 1H),7.43-7.51 (m, 2H), 7.89 (s, 1H).

LC/MS (ES⁺) 340, 342 (Na⁺ adduct).

LC/MS (ES⁻) 363, 364, 365 (HCO₂ ⁻ adduct).

Reference Synthetic Example 21 Synthesis of2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene

From2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene(1.8 g, 4.9 mmol), the desired product was obtained in the same manneras in Reference Synthetic Example 19 as a yellow oil (1.4 g, yield 92%).

¹H-NMR (ppm in CDCl₃)

δ 3.50 (s, 3H), 4.57 (s, 2H), 4.91 (s, 2H), 7.24 (s, 1H), 7.64 (d, J=8.4Hz, 2H), 7.78 (d, J=8.4 Hz, 2H).

LC/MS (ES⁺) 341 (Na⁺ adduct).

Reference Synthetic Example 22 Synthesis of2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene

Dimethyl sulfoxide (0.050 mL, 0.70 mmol) in dichloromethane (0.28 mL)was added to oxalyl chloride (0.049 mL, 0.56 mmol) in dichloromethane(2.8 mL) at −78° C., and after 10 minutes of stirring at −78° C.,2-(4-t-butylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene (87 mg,0.28 mmol) in dichloromethane (0.93 mL) was added dropwise. After theaddition, the reaction solution was stirred at −78° C. for 20 minutesand at −40 to −50° C. for 1 hour. Triethylamine (0.28 mL, 2.0 mmol) wasadded dropwise, and the reaction solution was stirred for another 20minutes under cooling with ice. After addition of saturated aqueousammonium chloride, the reaction solution was extracted with chloroform,and the organic layer was washed with saturated aqueous sodium chloride,dried over anhydrous sodium sulfate and concentrated to give the desiredproduct as a brown oil (58 mg, yield 68%).

¹H-NMR (ppm in CDCl₃)

δ 1.25 (s, 9H), 3.24 (s, 3H), 4.91 (s, 2H), 7.34-7.38 (m, 2H), 7.50-7.54(m, 2H), 7.91 (s, 1H), 9.82 (s, 1H).

LC/MS (ES⁺) 305.

Reference Synthetic Example 23 Synthesis of2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-formylthiophene

From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene(4.3 g, 14 mmol), the desired product was obtained in the same manner asin Reference Synthetic Example 22 as a colorless oil (5.2 g, yield122%).

¹H-NMR (ppm in CDCl₃)

δ 3.50 (s, 3H), 5.04 (s, 2H), 7.48-7.54 (m, 2H), 7.84 (d, J=1.7 Hz, 1H),8.04 (s, 1H), 9.88 (s, 1H).

Reference Synthetic Example 24 Synthesis of2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene

2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene(1.4 g, 4.3 mmol) in chloroform (22 ml) was stirred with manganesedioxide (3.7 g, 43 mmol) at room temperature for 20 hours and at 50° C.for 3 hours. The reaction solution was filtered, and the filtrate wasconcentrated and purified by silica gel column chromatography(n-hexane/ethyl acetate=3/1) to give the desired product as a colorlessoil (0.79 g, yield 57%).

¹H-NMR (ppm in CDCl₃)

δ 3.29 (s, 3H), 5.03 (s, 2H), 7.68 (d, J=8.5 Hz, 2H), 7.82 (d, J=8.5 Hz,2H), 8.08 (s, 1H), 9.91 (s, 1H).

LC/MS (ES⁺) 339 (Na⁺ adduct).

Reference Synthetic Example 25 Synthesis of2-(4-t-butylphenyl)-3-hydroxy-4-formylthiophene

To 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene (0.20 g,0.66 mmol) in 1,4-dioxane (1.3 mL), 1 M hydrochloric acid (0.66 mL, 0.66mmol) was added dropwise, and the reaction solution was stirred at 65°C. for 1 hour and at 80° C. for 1 hour. After addition of water, thereaction solution was extracted with ethyl acetate, and the organiclayer was washed with saturated aqueous sodium chloride, dried overanhydrous sodium sulfate, concentrated and purified by silica gel columnchromatography (chloroform) to give the desired product as a reddishbrown oil (0.12 g, yield 68%).

¹H-NMR (ppm in CDCl₃)

δ 1.38 (s, 9H), 7.43 (d, J=8.4 Hz, 2H), 7.70 (d, J=8.4 Hz, 2H), 7.88 (s,1H), 9.24 (s, 1H), 9.85 (s, 1H).

Reference Synthetic Example 2.6 Synthesis of2-(3,4-dichlorophenyl)-3-hydroxy-4-formylthiophene

From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-formylthiophene (1.7 g,5.4 mmol), the desired product was obtained in the same manner as inReference Synthetic Example 25 as a brown oil (1.2 g, yield 83%).

¹H-NMR (ppm in DMSO-d₆)

δ 7.68 (s, 2H), 7.80 (s, 1H), 8.48 (s, 1H), 9.89 (s, 1H), 10.07 (s, 1H).

LC/MS (ES⁻) 271, 273.

Reference Synthetic Example 27 Synthesis of2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene

3.0 M Ethyl ether solution (2.0 mL, 6.0 mmol) of methylmagnesium bromidewas added dropwise to2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene (0.77 g, 2.5mmol) in THF (2.5 mL) under cooling with ice, and the reaction solutionwas stirred for 1 hour under cooling with ice. After addition ofsaturated aqueous ammonium chloride, the reaction solution was extractedwith ethyl acetate, and the organic layer was washed with saturatedaqueous sodium chloride, dried over anhydrous sodium sulfate,concentrated and purified by silica gel column chromatography(n-hexane/ethyl acetate=9/1) to give the desired product as a paleyellow oil (0.64 g, yield 80%).

³H-NMR (ppm in CDCl₃)

δ 1.34 (s, 9H), 1.58-1.60 (m, 3H), 3.24 (bs, 1H), 3.48 (s, 3H),4.83-4.85 (m, 1H), 4.92-4.95 (m, 2H), 7.08 (s, 1H), 7.38-7.42 (m, 2H),7.54-7.57 (m, 2H).

LC/MS (ES⁺) 343 (Na⁺ adduct).

Reference Synthetic Example 28 Synthesis of2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl) thiophene

From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-formylthiophene (0.75g, 2.4 mmol), the desired product was obtained in the same manner as inReference Synthetic Example 27 as a pale yellow oil (0.76 g, yield 95%).

¹H-NMR (ppm in CDCl₃)

δ 1.57-1.62 (m, 3H), 3.05 (bs, 1H), 3.50 (s, 3H), 4.82-4.85 (m, 1H),4.90-4.95 (m, 2H), 7.17 (d, J=2.5 Hz, 1H), 7.53-7.59 (m, 2H), 7.77 (s,1H).

Reference Synthetic Example 29 Synthesis of2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene

From 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene(0.79 g, 2.5 mmol), the desired product was obtained in the same manneras in Reference Synthetic Example 27 as a yellow oil (0.76 g, yield92%).

¹H-NMR (ppm in CDCl₃)

δ 1.59 (d, J=6.3 Hz, 3H), 3.09 (bs, 1H), 3.48 (s, 3H), 4.83 (d, J=6.3Hz, 1H), 4.92 (s, 2H), 7.20 (s, 1H), 7.64 (d, J=8.4 Hz, 2H), 7.76 (d,J=8.4 Hz, 2H).

Reference Synthetic Example 30 Synthesis of2-(4-t-butylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene

2-(4-t-Butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene (0.64g, 2.0 mmol) in dichloromethane (13 mL) was stirred with celite (2.0 g)and pyridinium chlorochromate (0.86 g, 4.0 mmol) at room temperature for1 hour. The reaction solution was filtered through celite, and thefiltrate was concentrated and purified by silica gel columnchromatography (n-hexane/ethyl acetate=1/1) to give the desired productas a brown solid (0.53 g, yield 83%).

¹H-NMR (ppm in CDCl₃)

δ 1.34 (s, 9H), 2.57 (s, 3H), 3.23 (s, 3H), 4.93 (s, 2H), 7.41-7.44 (m,2H), 7.57-7.61 (m, 2H), 7.88 (s, 1H).

Reference Synthetic Example 31 Synthesis of2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene

From2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene(0.76 g, 2.3 mmol), the desired product was obtained in the same manneras in Reference Synthetic Example 30 as a colorless solid (0.62 g, yield81%).

¹H-NMR (ppm in CDCl₃)

δ 2.56 (s, 3H), 3.27 (s, 3H), 4.98 (s, 2H), 7.46-7.54 (m, 2H), 7.84 (d,J=1.9 Hz, 1H), 7.95 (s, 1H).

Reference Synthetic Example 32 Synthesis of2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene

From 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene (0.76 g, 2.3 mmol), the desired product was obtained in thesame manner as in Reference Synthetic Example 30 as a yellow oil (0.64g, yield 84%).

¹H-NMR (ppm in CDCl₃)

δ 2.57 (s, 3H), 3.20 (s, 3H), 4.96 (s, 2H), 7.67 (d, J=8.6 Hz, 2H), 7.82(d, J=8.6 Hz, 2H), 7.98 (s, 1H).

Reference Synthetic Example 33 Synthesis of2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene

From 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene(0.53 g, 1.7 mmol), the desired product was obtained in the same manneras in Reference Synthetic Example 25 as a yellow solid (0.38 g, yield80%).

¹H-NMR (ppm in CDCl₃)

δ 1.33 (s, 9H), 2.56 (s, 3H), 7.40-7.44 (m, 2H), 7.69-7.74 (m, 2H), 7.85(s, 1H), 10.28 (s, 1H).

LC/MS (ES⁺) 275.

Reference Synthetic Example 34 Synthesis of2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene

From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene(0.62 g, 1.9 mmol), the desired product was obtained in the same manneras in Reference Synthetic Example 25 as a yellow solid (0.31 g, yield57%).

¹H-NMR (ppm in DMSO-d₆)

δ 2.58 (s, 3H), 7.65-7.66 (m, 2H), 7.97 (d, J=1.0 Hz, 1H), 8.71 (s, 1H),10.59 (s, 1H).

Reference Synthetic Example 35 Synthesis of2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene

From2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene(0.64 g, 1.9 mmol), the desired product was obtained in the same manneras in Reference Synthetic Example 25 as a yellow solid (0.47 g, yield86%).

¹H-NMR (ppm in CDCl₃)

δ 2.59 (s, 3H), 7.63 (d, J=8.3 Hz, 2H), 7.91 (d, J=8.3 Hz, 2H), 7.96 (s,1H), 10.57 (s, 1H).

LC/MS (ES⁺) 287.

Reference Synthetic Example 36 Synthesis of oxo(phenyl)acetaldehydemethylhydrazone

A mixed solution of methylhydrazine (0.554 mL, 10.5 mmol)/acetic acid (1mL)/water (7.6 mL) was added to phenylglyoxal (1.34 g, 10 mmol) in water(130 mL), and the mixture was stirred at room temperature for 20 hours.The reaction solution was extracted with chloroform, and the extract wasdried, filtered, evaporated and dried by means of a vacuum pump to giveoxo(phenyl)acetaldehyde methylhydrazone (1.44 g (crude), yield 89%) as ayellow solid.

Reference Synthetic Example 37 Synthesis of 4-hydrazinocarbonylmethylbenzoate

The known procedure disclosed in the literature (SyntheticCommunications, 28(7), 1223-1231, (1998)) was followed using monomethylterephthalate and tetramethylfluoroformamidinium hexafluorophosphate togive 1.36 g of the desired product as a colorless solid (yield 70%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.86 (s, 3H), 4.56 (s, 2H), 7.93 (d, J=8.3 Hz, 2H), 8.02 (d, J=8.3 Hz,2H), 9.96 (bs, 1H).

Reference Synthetic Example 38 Synthesis of5-methoxycarbonyl-2-thiophenecarboxylic acid

Thiophene-2,5-dicarboxylic acid (1.72 g, 10 mmol) and sodium carbonate(3.18 g, 30 mmol) suspended in dimethylformamide (25 mL) were stirredwith methyl iodide (623 μL) at room temperature overnight. The sodiumsalt of the desired product was extracted with water, and 12 Mhydrochloric acid was added to the combined aqueous layer. The desiredproduct was extracted with ethyl acetate, and the combined organic layerwas washed with saturated aqueous ammonium chloride, dried overanhydrous magnesium sulfate and purified by silica gel columnchromatography to give 0.49 g of the desired product as a colorlesssolid (yield 28%).

¹H-NMR (ppm in CDCl₃)

δ 3.93 (s, 3H), 7.77 (d, J=4.2 Hz, 1H), 7.83 (d, J=4.2 Hz, 1H).

LC/MS (ESI) 186 (M⁺).

Reference Synthetic Example 39 Synthesis of methyl5-hydrazinocarbonyl-2-thiophenecarboxylate

The known procedure disclosed in the literature (J. Heterocyclic Chem.,28, 17, (1991).) was followed using5-methoxycarbonyl-2-thiophenecarboxylic acid synthesized in ReferenceSynthetic Example 38, thionyl chloride and hydrazine monohydrate to give144 mg of the desired product as a white solid (yield 72%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.84 (s, 3H), 4.57 (brs, 2H), 7.72 (d, J=4.2 Hz, 1H), 7.79 (d, J=4.2Hz, 1H), 10.06 (brs, 1H).

LC/MS (ESI) 200 (M⁺).

Reference Synthetic Example 40 Synthesis of methyl2-nitro-4-hydrazinocarbonylbenzoate

From 4-methoxycarbonyl-3-nitrobenzoic acid, thionyl chloride andhydrazine monohydrate, 758 mg of the desired product was obtained in thesame manner as in Reference Synthetic Example 39 as a white solid (yield79%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.88 (s, 3H), 4.67 (brs, 2H), 7.96 (d, J=7.8 Hz, 1H), 8.24 (dd, J=1.8,7.8 Hz, 1H), 8.44 (d, J=1.8 Hz, 1H).

LC/MS (ESI) 239 (M⁺).

Reference Synthetic Example 41 Synthesis of methyl2-chloro-4-hydrazinocarbonylbenzoate 1) Synthesis of3-chloro-4-methoxycarbonylbenzoic acid

To 3-amino-4-methoxycarbonylbenzoic acid (0.98 g, 5 mmol) suspended in12 M hydrochloric acid (25 mL) and acetic acid (25 mL), an aqueoussolution (10 mL) sodium nitrite (0.35 g, 5 mmol) was added at −10° C.,and the resulting solution was stirred for 30 minutes. The solution wasadded to copper chloride (I) (0.99 g, 10 mmol) in 12 M hydrochloric acid(25 mL) at −10° C., and the resulting reaction mixture was stirred atroom temperature for 1 hour. After addition of ethyl acetate, thereaction mixture was washed with water, dried over magnesium sulfate,filtered through celite and purified by silica gel column chromatographyto give 0.44 g of the desired product as a colorless solid (yield 39%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.98 (s, 3H), 7.89 (d, J=8.1 Hz, 1H), 8.02 (dd, J=1.5, 8.1 Hz, 1H),8.17 (d, J=1.5 Hz, 1H).

LC/MS (ESI) 214 (M⁺ ³⁵Cl), 216 (M⁺ ³⁷Cl).

2) Synthesis of methyl 2-chloro-4-hydrazinocarbonylbenzoate

From 3-chloro-4-methoxycarbonylbenzoic acid, thionyl chloride andhydrazine monohydrate, 423 mg of the desired product was obtained in thesame manner as in Reference Synthesis Example 39 as a while solid (yield93%

¹H-NMR (ppm in DMSO-d₆)

δ 3.88 (s, 3H), 4.63 (brs, 2H), 7.87-7.96 (m, 3H), 10.05 (brs, 1H).

LC/MS (ESI) 228 (M⁺ ³⁵Cl), 230 (M⁺ ³⁷Cl).

Reference Synthetic Example 42 Synthesis of methyl2-bromo-4-hydrazinocarbonylbenzoate 1) Synthesis of3-bromo-4-methoxycarbonylbenzoic acid

To 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) suspended in48% hydrobromic acid (50 mL) and acetic acid (50 mL), an aqueoussolution (20 mL) of sodium nitrite (0.69 g, 10 mmol) was added at −10°C., and the resulting solution was stirred for 30 minutes. The solutionwas added to copper bromide (I) (1.44 g, 10 mmol) in 48% hydrobromicacid (50 mL) at −10° C., and the resulting reaction mixture was stirredat room temperature for 1 hour. After addition of ethyl acetate, thereaction mixture was washed with water, dried over magnesium sulfate,filtered through celite and purified by silica gel column chromatographyto give 1.70 g of the desired product as a colorless solid (yield 59%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.97 (s, 3H), 7.84 (d, J=8.1 Hz, 1H), 8.07 (dd, J=1.5, 8.1 Hz, 1H),8.37 (d, J=1.5 Hz, 1H).

LC/MS (ESI) 258 (M⁺ ⁷⁹ Br), 260 (M⁺ ⁸¹Br).

2) Synthesis of methyl 2-bromo-4-hydrazinocarbonylbenzoate

From 3-bromo-4-methoxycarbonylbenzoic acid, thionyl chloride andhydrazine monohydrate, 489 mg of the desired product was obtained in thesame manner as in Reference Synthesis Example 39 as a while solid (yield90%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.88 (s, 3H), 4.60 (brs, 2H), 7.83 (d, J=8.1 Hz, 1H), 7.90 (dd, J=1.5,8.1 Hz, 1H), 8.13 (d, J=1.5 Hz, 1H), 10.04 (brs, 1H).

LC/MS (ESI) 272 (M⁺ ⁷⁹ Br), 274 (M⁺ ⁸¹ Br)

Reference Synthetic Example 43 Synthesis of methyl4-hydrazinocarbonyl-2-hydroxybenzoate 1) Synthesis of3-hydroxy-4-methoxycarbonylbenzoic acid

To 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) suspended in3 M hydrochloric acid (12.5 mL) and acetic acid (20 mL), an aqueoussolution (20 mL) of sodium nitrite (0.69 g, 10 mmol) was added at −10°C., and the resulting solution was stirred for 30 minutes. The solutionwas added to 10% aqueous sulfuric acid (30 mL) at 0° C., and theresulting reaction mixture was heated with reflux for 1 hour. Thedesired product was extracted with ethyl acetate, and the extract wasdried over magnesium sulfate and purified by silica gel columnchromatography to give 1.04 g of the desired product as a white solid(yield 53%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.86 (s, 3H), 7.43 (d, J=8.1 Hz, 1H), 7.49 (s, 1H), 7.75 (d, J=8.1 Hz,1H), 10.55 (brs, 1H).

LC/MS (ESI) 196 (M⁺).

2) Synthesis of methyl 4-hydrazinocarbonyl-2-hydroxybenzoate

From 3-hydroxy-4-methoxycarbonylbenzoic acid, thionyl chloride andhydrazine monohydrate, 241 mg of the desired product was obtained in thesame manner as in Reference Synthesis Example 39 as a while solid (yield57%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.90 (s, 3H), 4.55 (brs, 2H), 7.34 (dd, J=1.5, 8.1

Hz, 1H), 7.38 (d, J=1.5 Hz, 1H), 7.82 (d, J=8.1 Hz, 1H), 9.91 (brs, 1H),10.52 (brs, 1H).

LC/MS (ESI) 210 (M⁺).

Reference Synthetic Example 44 Synthesis of2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene

From 2-(3-trifluoromethylphenyl)-3-hydroxy-4-ethoxycarbonylthiophene(1.2 g, 3.9 mmol), the desired product was obtained in the same manneras in Reference Synthesis. Example 16 as a brown oil (1.2 g; yield 88%).

¹H-NMR (ppm in CDCl₃)

δ 1.36-1.42 (m, 3H), 3.19 (s, 3H), 4.33-4.37 (m, 2H), 5.05 (s, 2H),7.53-7.56 (m, 2H), 7.83-7.85 (m, 1H), 8.02-8.07 (m, 2H).

LC/MS (ES⁺) 383 (Na⁺ adduct).

Reference Synthetic Example 45 Synthesis of2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene

From2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene(1.2 g, 3.4 mmol), the desired product was obtained in the same manneras in Reference Synthesis Example 19 as a pale yellow oil (1.0 g, yield95%).

¹H-NMR (ppm in CDCl₃)

δ 3.50 (s, 3H), 4.57 (d, J=5.2 Hz, 2H), 4.91 (s, 2H), 7.23 (s, 1H),7.48-7.56 (m, 2H), 7.80-7.82 (m, 1H), 7.96 (s, 1H).

LC/MS (ES⁺) 341 (Na⁺ adduct).

Reference Synthetic Example 46 Synthesis of2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene

From2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene(1.0 g, 3.2 mmol), the desired product was obtained in the same manneras in Reference Synthesis Example 24 as a brown oil (0.97 g, yield 96%).

¹H-NMR (ppm in CDCl₃)

δ 3.29 (s, 3H), 5.03 (s, 2H), 7.53-7.62 (m, 2H), 7.83-8.06 (m, 3H), 9.91(s, 1H).

LC/MS (ES⁺) 339 (Na⁺ adduct).

Reference Synthetic Example 47 Synthesis of2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene

From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene(0.97 g, 3.1 mmol), the desired product was obtained in the same manneras in Reference Synthesis Example 27 as a brown oil (0.97 g, yield 96%).

¹H-NMR (ppm in CDCl₃)

δ 1.59-1.62 (m, 3H), 3.47 (s, 3H), 4.82-4.94 (m, 3H), 7.19 (s, 1H),7.48-7.56 (m, 2H), 7.79-7.81 (m, 1H), 7.94 (s, 1H).

LC/MS (ES⁺) 355 (Na⁺ adduct).

Reference Synthetic Example 48 Synthesis of2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene

From2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene(0.99 g, 2.3 mmol), the desired product was obtained in the same manner,as in Reference Synthesis Example 30 as a brown oil (0.76 g, yield 77%).

¹H-NMR (ppm in CDCl₃)

δ 2.57 (s, 3H), 3.19 (s, 3H), 4.97 (s, 2H), 7.54-7.58 (m, 2H), 7.83-8.01(m, 3H).

LC/MS (ES⁺) 353 (Na⁺ adduct).

Reference Synthetic Example 49 Synthesis of2-(3-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene

From2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene(0.76 g, 2.3 mmol), the desired product was obtained in the same manneras in Reference Synthesis Example 25 as a pale brown solid (0.59 g,yield 90%).

¹H-NMR (ppm in CDCl₃)

δ 2.58 (s, 3H), 7.48-7.52 (m, 2H), 7.94-8.05 (m, 3H), 10.52 (s, 1H).

LC/MS (ES⁺) 287.

Reference Synthetic Example 50 Synthesis of methyl2-acetamino-4-hydrazinocarbonylbenzoate 1) Synthesis of3-acetamino-4-methoxycarbonylbenzoic acid

Acetic anhydride (1.89 mL, 20 mmol) was added to a suspension of3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) in acetic acid(10 mL), and the mixture was heated with reflux for 6 hours. Aftercooling, the precipitated solid was filtered to obtain 2.12 g of thedesired product as a colorless solid (yield 89%).

¹H-NMR (ppm in DMSO-d₆)

δ 2.13 (s, 3H), 3.87 (s, 3H), 7.71 (d, 1H, J=8.4 Hz), 7.96 (d, 1H, J=8.4Hz), 8.68 (s, 1H), 10.51 (brs, 1H).

LC/MS (ESI) 237 (M⁺).

2) Synthesis of methyl 2-acetamino-4-hydrazinocarbonylbenzoate

1-Hydroxybenzotriazole (HOBt) (270 mg, 2 mmol) and1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride (WSC) (498mg, 2.6 mmol) were added to a solution of3-acetamino-4-methoxycarbonylbenzoic acid (474 mg, 2 mmol) indimethylformamide (10 mL), and the mixture was stirred at roomtemperature for 3 hours. Hydrazine monohydrate (485 μL, 10 mmol) wasfurther added at 0° C., and the mixture was stirred overnight at roomtemperature. The precipitated solid was filtered, and then washed withwater to obtain 400 mg of the desired product as a white solid (yield80%).

¹H-NMR (ppm in DMSO-d₆)

δ 2.12 (s, 3H), 3.85 (s, 3H), 4.55 (brs, 2H), 7.55 (d, 1H, J=8.1 Hz),7.90 (d, 1H, J=8.1 Hz), 8.49 (s, 1H), 9.92 (brs, 1H), 10.48 (brs, 1H).

LC/MS (ESI) 251 (M⁺).

Reference Synthetic Example 51 Synthesis of methyl2-fluoro-4-hydrazinocarbonylbenzoate 1) Synthesis of methyl4-bromo-2-fluorobenzoate

Methyl iodide (1.49 mL, 24 mmol) was added to a suspension of4-bromo-2-fluorobenzoic acid (4.38 g, 20 mmol) and sodium carbonate(6.36 g, 60 mmol) in dimethylformamide (50 mL), and the mixture wasstirred overnight at room temperature. After completion of the reaction,ethyl acetate was added, and the mixture was washed with water and asaturated ammonium chloride aqueous solution. After drying overmagnesium sulfate, concentration was carried out to obtain 4.50 g of thedesired product as a colorless solid (yield 97%).

¹H-NMR (ppm in CDCl₃)

δ 3.93 (s, 3H), 7.33-7.38 (m, 2H), 7.80-7.85 (m, 1H).

2) Synthesis of methyl 4-benzyloxycarbonyl-2-fluorobenzoate

Palladium diacetate (4.5 mg, 0.02 mmol),1,4-(bisdiphenylphosphino)butane (8.5 mg, 0.02 mmol), triethylamine(55.8 μL, 0.4 mmol) and benzyl alcohol (1 mL) were added to a solutionof methyl 4-bromo-2-fluorobenzoate (46.6 mg, 0.2 mmol) indimethylformamide (1 mL). In this solution, bubbling was carried out fora few minutes with carbon monoxide, and then this solution was heated at120° C. for 12 hours under carbon monoxide atmosphere. After completionof the reaction, ethyl acetate was added, and the resultant product waswashed with a saturated ammonium chloride aqueous solution, and purifiedwith a silica gel column chromatography (hexane/ethyl acetate=19/1) toobtain 35.4 mg of the desired product as a yellow viscous liquid (yield61%).

¹H-NMR (ppm in CDCl₃)

δ 3.95 (s, 3H), 5.38 (s, 2H), 7.35-7.46 (m, 5H), 7.79-8.02 (m, 3H).

3) Synthesis of 3-fluoro-4-methoxycarbonylbenzoic acid

Catalytic amount of 10 wt % palladium carbon was added to a solution ofmethyl 4-benzyloxycarbonyl-2-fluorobenzoate (35.4 mg, 0.123 mmol) inethanol (2 mL), and the mixture was stirred overnight at roomtemperature under hydrogen atmosphere. After completion of the reaction,the mixture was filtered through celite and the filtrate wasconcentrated to obtain 26.0 mg of the desired product as a colorlesssolid (yield 100%).

¹H-NMR (ppm in CDCl₃)

δ 3.97 (s, 3H), 7.83-8.06 (m, 3H).

LC/MS (ESI) 198 (M⁺).

4) Synthesis of methyl 2-fluoro-4-hydrazinocarbonylbenzoate

From 3-fluoro-4-methoxycarbonylbenzoic acid (198 mg, 1 mmol),1-hydroxybenzotriazole (HOBt) (135 mg, 1 mmol),1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride (WSC) (249mg, 1.3 mmol) and hydrazine monohydrate (73 μL, 1.5 mmol), 45.6 mg ofthe desired product was obtained in the same manner as in ReferenceSynthesis Example 50 as a white solid (yield 22%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.87 (s, 3H), 4.60 (brs, 2H), 7.71-7.77 (m, 2H), 7.94-7.99 (m, 1H),10.06 (brs, 1H).

LC/MS (ESI) 212 (M⁺).

Reference Synthetic Example 52 Synthesis of2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyisobutyl)thiophene

To a solution of2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene (3.0 g, 10mmol) in THF (2.5 mL), 2.0 M ethyl ether solution (6.0 mL, 12 mmol) ofisopropylmagnesium bromide was added dropwise under cooling with ice,followed by stirring for 2.5 hours under cooling with ice. A saturatedammonium chloride aqueous solution was added to the reaction solution,and then extraction was carried out with ethyl acetate, and the organiclayer was washed with a saturated sodium chloride solution and thendried over anhydrous sodium sulfate. The obtained organic layer wasconcentrated, and then purification was carried out with a silica gelcolumn chromatography (n-hexane/ethyl acetate=3/1) to obtain the desiredproduct as a pale yellow oil (1.18 g, yield 34%).

¹H-NMR (ppm in CDCl₃)

δ 0.91 (d, J=6.6 Hz, 3H), 1.10 (d, J=6.6 Hz, 3H), 1.34 (s, 9H),2.15-2.25 (m, 1H), 3.46 (s, 3H), 4.35 (d, J=8.0 Hz, 1H), 4.86 (s, 2H),7.04 (s, 1H), 7.39 (d, J=8.8 Hz, 2H), 7.56 (d, J=8.8 Hz, 2H).

LC/MS (ES⁻) 303.

Reference Synthetic Example 53 Synthesis of2-(4-t-butylphenyl)-3-methoxymethyloxy-4-isopropylcarbonylthiophene

Using2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyisobutyl)thiophene(1.07 g, 3.07 mmol) as the starting material, the desired product wasobtained in the same manner as in Reference Synthetic Example 30 as abrown oil (0.85 g, yield 80%).

¹H-NMR (ppm in CDCl₃)

δ 1.20 (s, 3H), 1.23 (s, 3H), 1.34 (s, 9H), 3.21 (s, 3H), 3.39-3.45 (m,1H), 4.92 (s, 2H), 7.42 (d, J=8.7 Hz, 2H), 7.61 (d, J=8.7 Hz, 2H), 7.83(s, 1H).

LC/MS (ES⁺) 369 (Na⁺ adduct).

Reference Synthetic Example 54 Synthesis of2-(4-t-butylphenyl)-3-hydroxy-4-isopropylcarbonylthiophene

Using2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(isopropylcarbonyl)thiophene(0.85 g, 2.5 mmol) as the starting material, the desired product wasobtained in the same manner as in Reference Synthetic Example 25 as apale brown solid (0.42 g, yield 56%).

¹H-NMR (ppm in CDCl₃)

δ 1.26 (s, 3H), 1.28 (s, 3H), 1.34 (s, 9H), 3.36-3.41 (m, 1H), 7.42 (d,J=8.8 Hz, 2H), 7.72 (d, J=8.8 Hz, 2H), 7.89 (s, 1H), 10.50 (s, 1H).

LC/MS (ES⁺) 303.

Reference Synthetic Example 55 Synthesis of2-bromo-5-(4-t-butylphenyl)-4-hydroxy-3-methylcarbonylthiophene

2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (2.66 g, 9.7mmol), N-bromosuccinimide (1.73 g, 9.7 mmol) and benzoyl peroxide (153mg, 0.63 mmol) were heated with reflux for 2 hours in 65 ml ofchloroform. Water was added, and the reaction solution was extractedthree times with chloroform, and the organic layer was washed with asaturated aqueous sodium chloride solution, and then dried overanhydrous sodium sulfate. The obtained organic layer was concentrated,and then purified with a silica gel column chromatography(n-hexane/chloroform=3/2) to obtain the desired product as a yellowsolid (2.93 g, yield 86%).

¹H-NMR (ppm in CDCl₃)

δ=1.33 (s, 9H), 2.79 (s, 3H), 7.39-7.43 (m, 2H), 7.62-7.66 (m, 2H),10.91 (s, 1H).

LC/MS (ES⁻) 351, 353.

Reference Synthetic Example 56 Synthesis of methyl4-hydrazinocarbonothioylamino-2-nitrobenzoate 1) Synthesis of methyl4-amino-2-nitrobenzoate

To a suspension of 4-amino-2-nitrobenzoic acid (200 mg, 1.10 mmol)synthesized in accordance with the synthesis method described inWO96/35666 and sodium carbonate (349 mg, 3.29 mmol) in dimethylformamide(5.5 mL), methyl iodide (0.21 ml) was added, and the mixture was stirredovernight at room temperature. Water was added to the reaction solution,and extraction was carried out with ethyl acetate, and the combinedorganic layer was washed with a saturated ammonium chloride aqueoussolution and a saturated sodium chloride aqueous solution, followed bydrying over anhydrous sodium sulfate. By concentrating the obtainedorganic layer, 216 mg of the desired product was obtained as a yellowsolid (yield 100%).

¹H-NMR (ppm in CDCl₃)

δ 7.69 (d, J=8.5 Hz, 1H), 6.85 (d, J=2.4 Hz, 1H), 6.77 (dd, J=2.4, 8.5Hz, 1H), 4.31 (bs, 2H), 3.84 (s, 3H).

LC/MS (ESI) 196.

2) Synthesis of 4-methoxycarbonyl-3-nitrophenyl isothiocyanate

A solution of the above synthesized methyl 4-amino-2-nitrobenzoate (50mg, 0.25 mmol) and 1,1′-thiocarbonyldi-2(1H)-pyridone (59 mg, 0.25 mmol)in dichloromethane (4.2 ml) was stirred at room temperature for 3 hours.After completion of the reaction, the solvent was evaporated, followedby purification with a silica gel column chromatography to obtain 42 mgof the desired product as a colorless oil (yield 69%).

¹H-NMR (ppm in CDCl₃)

δ 7.79 (d, J=8.3 Hz, 1H), 7.66 (d, J=2.1 Hz, 1H), 7.47 (dd, J=2.1, 8.3Hz, 1H), 3.92 (s, 3H).

LC/MS (ES⁻) 224 (M⁺-CH₂).

3) Synthesis of methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate

A solution of the above synthesized 4-methoxycarbonyl-3-nitrophenylisothiocyanate (149 mg, 0.62 mmol) in tetrahydrofuran (2.2 ml) was addeddropwise to a solution of hydrazine monohydrate (94 mg, 1.87 mmol) intetrahydrofuran (4.0 ml) at 0° C. over 20 minutes. After stirring at 0°C. for further 40 minutes, water was added, and the precipitated solidwas filtered to obtain 142 mg of the desired product as a colorlesssolid (yield 85%).

¹H-NMR (ppm in DMSO)

δ 9.67 (bs, 1H), 8.71 (bs, 1H), 8.18-8.21 (m, 1H), 7.76-7.83 (m, 2H),3.82 (s, 3H).

LC/MS (ESI) 270.

Reference Synthetic Example 57 Synthesis of methyl5-hydrazinocarbonothioylamino-2-thiophenecarboxylate 1) Synthesis ofmethyl 5-nitro-2-thiophenecarboxylate

From 5-nitrothiophene-2-carboxylic acid (3 g, 17.3 mmol), the desiredproduct was obtained in the same manner as in Reference SyntheticExample 56 as a pale pink solid (2.97 g, yield 92%).

¹H-NMR (ppm in CDCl₃)

δ 7.88 (d, J=4.3 Hz, 1H), 7.70 (d, J=4.3 Hz, 1H), 3.96 (s, 3H).

2) Synthesis of 5-methoxycarbonyl-2-thiophene isothiocyanate

To a solution of the above synthesized methyl5-nitro-2-thiophenecarboxylate (2.67 g, 14.3 mmol) and iron (2.63 g,47.1 mmol) in ethanol (50 ml) and water (9.9 ml), concentratedhydrochloric acid (0.12 ml, 1.43 mmol) was added at 90° C. And themixture was stirred at 90° C. for 30 minutes. After completion of thereaction, 1 M sodium hydroxide aqueous solution (1.43 ml, 1.43 mmol) wasadded thereto. The insolubles were filtered off, and the filtrate wasconcentrated and extracted with ethyl acetate, then dried over anhydroussodium sulfate. The obtained organic layer was concentrated and dried bymeans of a vacuum pump. From the resulting crude solid, the desiredproduct was obtained in the same manner as in Reference SyntheticExample 56 as a pale yellow oil (904 mg, yield 32%).

¹H-NMR (ppm in CDCl₃)

δ 7.56 (d, J=4.0 Hz, 1H), 6.83 (d, J=4.0 Hz, 1H), 3.88 (s, 3H).

LC/MS (ES⁺) 199.

3) Synthesis of methyl5-hydrazinocarbonothioylamino-2-thiophenecarboxylate

From the above synthesized methyl 5-methoxycarbonyl-2-thiopheneisothiocyanate (484 mg, 2.43 mmol), the desired product was obtained inthe same manner as in Reference Synthetic Example 56 as a colorlesssolid (435 mg, yield 77%).

¹H-NMR (ppm in DMSO)

δ 9.63 (bs, 1H), 7.55-7.57 (m, 1H), 7.12 (bs, 1H), 6.95 (bs, 1H), 3.76(s, 3H).

LC/MS (ESI) 231.

Reference Synthetic Example 58 Synthesis of methyl4-hydrazinocarbonothioylamino-2-chlorobenzoate 1) Synthesis of methyl4-amino-2-chlorobenzoate

From 4-amino-2-chlorobenzoic acid (500 mg, 2.91 mmol), the desiredproduct was obtained in the same manner as in Reference SyntheticExample 56 as a pale brown solid (535 mg, yield 99%).

¹H-NMR (ppm in CDCl₃)

δ 7.78 (d, J=8.5 Hz, 1H), 6.70 (d, J=2.2 Hz, 1H), 6.53 (dd, J=2.2 Hz,8.5 Hz, 1H), 4.07 (bs, 2H), 3.86 (s, 3H).

LC/MS (ES⁺) 185.

2) Synthesis of 4-methoxycarbonyl-3-chlorophenyl isothiocyanate

From the above synthesized methyl 4-amino-2-chlorobenzoate (505 mg, 2.72mmol), the desired product was obtained in the same manner as inReference Synthetic Example 56 as a colorless solid (424 mg, yield 69%).

¹H-NMR (ppm in CDCl₃)

δ 7.87 (d, J=8.3 Hz, 1H), 7.31 (d, J=2.0 Hz, 1H), 7.15 (dd, J=2.0 Hz,8.3 Hz, 1H), 3.93 (s, 3H).

LC/MS (ES⁺) 227.

3) Synthesis of methyl 4-hydrazinocarbonothioylamino-2-chlorobenzoate

From the above synthesized 4-methoxycarbonyl-3-chlorophenylisothiocyanate (420 mg, 1.85 mmol), the desired product was obtained inthe same manner as in Reference. Synthetic Example 56 as a colorlesssolid (364 mg, yield 76%).

¹H-NMR (ppm in DMSO)

δ 9.54 (bs, 1H), 8.24 (bs, 1H), 7.77-7.84 (m, 3H), 3.83 (s, 3H).

LC/MS (ESI) 259.

Reference Synthetic Example 59-66

Table 15 shows the number of the synthetic examples (S.E.) obtained inthe similar manner as described in the reference synthetic example(R.S.E.) 33, yields, shapes, LC/MS conditions (L.C.), LC/MS observedpeaks (O.P.) and retention times (R.T.).

TABLE 15 yields O.P. R.T. R.S.E. (%) shapes L.C. ESI⁺ ESI⁻ (min) 59 48pale brown solid 2 297/299 295/297 4.54 60 73 yellow solid 61 83 yellowsolid 9 303 301 3.34 62 93 brown solid 5 255 253 4.49 63 50 yellow solid9 237 235 2.99 64 44 green solid 2 237 235 4.22 65 53 yellow solid 2 247245 4.52 66 55 pale green solid 2 253/255 251/253 4.49

Reference Synthetic Example 67 Synthesis of2-(3,4-dichlorophenyl)-4-(1-hydrorazonoethyl)thiophen-3-ol

To a suspension of2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (300 mg, 1.05mmol) in isopropanol (20 mL) was added hydrazine monohydrate (61 μL,1.25 mmol). The reaction mixture was refluxed for 1.5 hours, stirred atroom temperature for 0.5 hour and at 0° C. for 1 hour. The precipitatedsolid was collected by filtration and dried by means of a vacuum pump togive the desired product as a pale yellow solid (yield 100%). ¹H-NMR(DMSO-d₆) δ(ppm): 2.10 (s, 3H), 6.63 (br s, 2H), 7.58 (s, 2H), 7.61 (s,1H), 7.98 (s, 1H)/12.88 (s, 1H).

LC/MS: condition 8, retention time 4.95 (min)

LC/MS (ESI⁺) m/z; 301, 303 [M+1]⁺

LC/MS (ESI⁻) m/z; 299, 301 [M−1]⁻

Reference Synthetic Example 68-75

Table 16 shows the number of the synthetic examples (S.E.) obtained inthe similar manner as described in the reference synthetic example(R.S.E.) 67, yields, shapes, LC/MS conditions (L.C.), LC/MS observedpeaks (O.P.) and retention times (R.T.).

TABLE 16 yields O.P. R.T. R.S.E. (%) shapes L.C. ESI⁺ ESI⁻ (min) 68 50pale yellow solid 3 267/269 265/267 3.52 69 89 pale yellow solid 2 299297 3.49 70 72 pale yellow solid 71 100 pale yellow solid 72 100 yellowsolid 9 263 261 4.85 73 100 pale yellow solid 3 311/313 309/311 3.57 7493 yellow solid 3 317 315 3.62 75 79 pale yellow solid 3 261 259 3.50The structural formulae of the compounds obtained in the ReferenceSynthetic Example 59-75 are given below.

Synthetic Example 1 Synthesis of4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (1.525 mmol, 152.7 mg) synthesized inReference Synthetic Example 1 and (3,4-dichlorophenyl)(oxo)acetaldehyde(1.525 mmol, 310 mg) synthesized in Reference Synthetic Example 3 weredissolved in acetic acid (10 mL) and stirred at 110° C. for 1.5 hours.Then, the solvent was evaporated, and the residue was dried by means ofa vacuum pump, resolved by silica gel thin layer chromatography(n-hexane/AcOEt=3/2) and purified by silica gel thin layerchromatography (n-hexane/AcOEt=2/1) to give the desired product as ayellow solid (57.8 mg, yield 13%).

¹H-NMR (ppm in CDCl₃)

δ 8.25 (s, 1H), 7.58 (br.s, 1H), 7.55 (br.s, 1H), 7.33 (br.dd, 1H), 3.92(s, 3H), 2.58 (s, 3H).

¹³C-NMR (ppm in CDCl₃)

δ 198.1, 143.8, 135.6, 133.2, 132.7, 130.9, 130.4, 127.8, 127.6, 125.8,39.3, 25.6.

LC-MS (ESI) 284 (M⁺).

2) Synthesis of4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methylbenzoate

1-[5-(3,4-Dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.1336 mmol, 38 mg), 4-hydrazinocarbonylmethyl benzoate (0.1336 mmol,26 mg) and p-tosylic acid monohydrate (30 mol %, 6.9 mg) were dissolvedin isopropyl alcohol (2.5 mL) and stirred at 100° C. for 3.5 hours.Then, the reactor was cooled to 0° C., and the precipitated solid wasrecovered by filtration and dried by means of a vacuum pump to give thedesired product as a white solid (30.5 mg, yield 50%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.46 (s, 1H), 9.95 (s, 1H), 8.10 (ABq, J=8.3 Hz, 2H), 8.04 (ABq,J=8.3 Hz, 2H), 7.86 (d, J=2.0 Hz, 1H), 7.80 (d, J=8.3 Hz, 1H), 7.61 (dd,J=2.0, 8.3 Hz, 1H), 3.90 (s, 3H), 3.90 (s, 3H), 2.45 (s, 3H).

LC-MS (ESI) 460 (M⁺).

3) Synthesis of4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methylbenzoate (0.0518 mmol, 23.9 mg), methanol (3 mL) was added, and 1 Maqueous sodium hydroxide (0.259 mmol, 0.259 mL) was added at roomtemperature. After 20 minutes of stirring at room temperature and 2hours of stirring at 60° C., the reactor was cooled to room temperature,and 1 M hydrochloric acid (0.259 mmol, 0.259 mL) and water were added.The precipitated solid was recovered by filtration, washed with waterand dried by means of a vacuum pump to give the desired product as ayellow solid (8.7 mg, yield 37%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.43 (s, 1H), 9.96 (s, 1H), 8.13-7.98 (multi, 4H), 7.86-7.78 (multi,2H), 7.62-7.51 (multi, 1H), 3.90-3.87 (multi, 3H), 2.46-2.45 (multi,3H).

LC-MS (ESI) 446 (M⁺).

Synthetic Example 2 Synthesis of4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[5-(3,4-Dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.139 mmol, 39.7 mg) synthesized in Synthetic Example 1 and4-hydrazinocarbonothioylaminobenzoic acid (0.139 mmol, 29.4 mg) werestirred with dimethylformamide (4 mL) and two drops of concentratedhydrochloric acid at room temperature for 22 hours. After addition ofwater, the precipitated yellow solid was recovered by filtration, washedwith water and dried by means of a vacuum pump. The resulting solid wasstirred with chloroform/n-hexane for a while, then recovered byfiltration and dried by means of a vacuum pump to give the desiredproduct as a yellow solid (39.5 mg, yield 59%).

¹H-NMR (ppm in DMSO-d₆)

δ10.36 (s, 1H), 10.33 (s, 1H), 9.15 (s, 1H), 7.93 (ABq, J=8.6 Hz, 2H),7.85-7.83 (multi, 2H), 7.79 (ABq, J=8.6 Hz, 2H), 7.58 (d, J=8.4 Hz, 1H),3.85 (s, 3H), 2.39 (s, 3H).

LC-MS (ESI) 477 (M⁺).

Synthetic Example 3 Synthesis of4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (46.375 mmol, 4.64 g) synthesized inReference Synthetic Example 1 and (4-tert-butylphenyl)(oxo)acetaldehydesynthesized in Reference Synthetic Example 4 (46.375 mmol, 8.82 g) weredissolved in acetic acid (140 mL) and stirred at 100° C. for 2 hours.The reactor was cooled to room temperature, and after addition of water(100 mL) and saturated aqueous sodium chloride (50 mL), it was extractedwith chloroform three times. The resulting organic layer was dried andfiltered, and the solvent was evaporated. The residue was purified bysilica gel column chromatography (n-hexane/ethyl acetate=4/1) to givethe desired product as a yellow solid (5.79 g, yield 46%).

¹H-NMR (ppm in CDCl₃)

δ 8-16 (s, 1H, exchangeable with D₂O), 7.51 (ABq, J=8.4 Hz, 2H), 7.40(ABq, J=8.4 Hz, 2H), 3.91 (s, 3H), 2.58 (s, 3H), 1.35 (s, 9H).

¹H-NMR (ppm in DMSO-d₆)

δ 8.50 (s, 1H), 7.53 (ABq, J=8.6 Hz, 2H), 7.44 (ABq, J=8.6 Hz, 2H), 3.83(s, 3H), 2.46 (s, 3H), 1.32 (s, 9H).

¹³C-NMR (ppm in CDCl₃)

δ 198.2, 151.6, 143.4, 135.6, 128.5, 128.3, 125.8, 124.7, 39.1, 34.7,31.2, 25.6.

LC-MS (ESI) 272 (M⁺).

2) Synthesis of4-[(2-{1-[5-(4-tert-butylphenyl)-4*-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methylbenzoate

1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.441 mmol, 120.0 mg), 4-hydrazinocarbonylmethyl benzoate (0.441 mmol,85.6 mg) and p-tosylic acid monohydrate (30 mol %, 22.8 mg) weredissolved in isopropyl alcohol (10 mL) and stirred at 100° C. for about3 hours and then at 50° C. overnight. The reactor was cooled to 0° C.,and the reaction solution was filtered and dried by means of a vacuumpump to give the desired product as a white solid (145.1 mg, yield 73%).

¹H-NMR (ppm in CDCl₃)

δ 8.98 (s, 1H), 8.78 (br.s, 1H), 8.16-8.13 (multi, 2H), 7.92-7.80(multi, 2H), 7.51-7.32 (multi, 4H), 3.95-3.88 (multi, 6H), 2.54 and 2.44(sx2, 3H), 1.35 (s, 9H).

LC-MS (ESI) 448 (M⁺).

3) Synthesis of4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methylbenzoate (0.0816 mmol, 36.6 mg), methanol (2.5 mL) was added, and then 1M aqueous sodium hydroxide (0.408 mmol. 0.408 mL) was added. After 22hours of stirring at room temperature, 1 M hydrochloric acid (0.408mmol, 0.408 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water, dried by means of a vacuumpump and purified by silica gel thin layer chromatography(chloroform/methanol=5/1) to give the desired product as a yellow solid(35.0 mg, yield 99%).

¹H-NMR (ppm in DMSO-d₆)

δ 8.13-7.98 (multi, 4H), 7.59-7.43 (multi, 4H), 3.88 and 3.84 (sx2, 3H),2.46 and 2.45 (sx2, 3H), 1.34 and 1.32 (sx2, 9H).

LC-MS (ESI) 434 (M⁺).

Synthetic Example 4 Synthesis of3-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]methylbenzoate

1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.192 mmol, 52.2 mg) synthesized in Synthetic Example3,3-hydrazinocarbonylmethyl benzoate (0.192 mmol, 37.2 mg) and p-tosylicacid monohydrate (30 mol %, 9.9 mg) were dissolved in isopropyl alcohol(7 mL) and stirred at 100° C. for about 15 hours. Then, the reactor wascooled to room temperature, and the reaction solution was filtered anddried by means of a vacuum pump to give the desired product as a whitesolid (65.3 mg, yield 76%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.42 (s, 1H), 9.70 (s, 1H), 8.47 (s, 1H), 8.19 (br.t, 2H), 7.71 (t,J=7.7 Hz, 1H), 7.55 (ABq, J=8.7 Hz, 2H), 7.51 (ABq, J=8.7 Hz, 2H), 3.92(s, 3H), 3.85 (s, 3H), 2.46 (s, 3H), 1.34 (s, 9H).

LC-MS (ESI) 448 (M⁺).

Synthetic Example 5 Synthesis of3-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To3-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methylbenzoate (0.119 mmol, 53.4 mg), methanol (2.5 mL) was added, and then 1M aqueous sodium hydroxide (0.595 mmol, 0.595 mL) was added. After 1hour of stirring at room temperature and 1 hour of stirring at 60° C.,the reactor was cooled to room temperature, and 1 M hydrochloric acid(0.595 mmol, 0.595 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. The resulting mixture was resolved by silica gel thin layerchromatography (CHCl₃/MeOH=10/1) to give the desired product as a paleyellow solid (34 mg, yield 66%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.41 (s, 1H), 9.72 (s, 1H), 8.55 and 8.46 (sx2, 1H), 8.16-8.14(multi, 2H), 7.71-7.63 (multi, 1H), 7.58-7.50 (multi, 4H), 3.94 and 3.85(sx2, 3H), 2.46 (s, 3H), 1.34 (s, 9H).

LC-MS (ESI) 434 (M).

Synthetic Example 6 Synthesis of4-{[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.163 mmol, 44.4 mg) synthesized in Synthetic Example 3 and4-hydrazinocarbonothioylaminobenzoic acid (0.163 mmol, 34.4 mg) werestirred with dimethylformamide (3 mL) and two drops of concentratedhydrochloric acid at room temperature for 20 hours. After addition ofwater, the precipitated yellow solid was recovered by filtration, washedwith water and dried by means of a vacuum pump. The resulting solid wasstirred with chloroform/n-hexane for a while, then recovered byfiltration and dried by means of a vacuum pump to give the desiredproduct as a yellow solid (37 mg, yield 48%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.88 (s, 1H), 10.34 (s, 1H), 8.86 (s, 1H), 7.95-7.84 (multi, 4H),7.59-7.47 (multi, 4H), 3.83 and 3.81 (sx2, 3H), 2.46 and 2.39 (sx2, 3H),1.34 and 1.33 (sx2, 9H).

LC-MS (ESI) 465 (M⁺).

Synthetic Example 7 Synthesis of4-{[(2-{1-[5-(4-tert-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoicacid 1) Synthesis of1-[5-(4-tert-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethanone

2-Oxopropanal ethylhydrazone (4.736 mmol, 540.6 mg) synthesized inReference Synthetic Example 2 and (4-tert-butylphenyl)(oxo)acetaldehyde(4.736 mmol, 901.0 mg) synthesized in Reference Synthetic Example 4 weredissolved in acetic acid (20 mL) and stirred at 100° C. for about 3.5hours. Then, the solvent was evaporated, and the residue was dried bymeans of a vacuum pump and purified by silica gel thin layerchromatography (n-hexane/AcOEt=1/2, 3/1 and 4/1) to give the desiredproduct as an orange liquid (212 mg, yield 160).

¹H-NMR (ppm in CDCl₃)

δ 8.12 (s, 1H), 7.50 (ABq, J=8.6 Hz, 2H), 7.36 (ABq, J=8.6 Hz, 2H), 4.19(q, J=7.2 Hz, 2H), 2.59 (s, 3H), 1.42 (t, J=7.2 Hz, 3H), 1.36 (s, 9H).

LC-MS (ESI) 286 (M⁺).

2) Synthesis of4-{[(2-{1-[5-(4-tert-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoicacid

1-[5-(4-tert-Butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethanone(0.1718 mmol, 49.2 mg) and 4-hydrazinocarbonothioylaminobenzoic acid(0.1718 mmol, 36.3 mg) were stirred with dimethylformamide (3 mL) andtwo drops of concentrated hydrochloric acid at room temperature for 21hours. After addition of water, the precipitated yellow solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. The resulting solid was stirred with chloroform/n-hexanefor a while, then recovered by filtration and dried by means of a vacuumpump to give the desired product as a yellow solid (59 mg, yield 72%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.89 (s, 1H), 10.33 (s, 1H), 8.77 (s, 1H), 7.94-7.84 (multi, 4H),7.60-7.41 (multi, 4H), 4.08 (q, J=7.2 Hz, 2H), 2.47 and 2.41 (sx2, 3H),1.34 and 1.33 (sx2, 9H), 1.27 (t, J=7.2 Hz, 3H).

LC-MS (ESI) 479 (M⁺).

Synthetic Example 8 Synthesis of4-{[(2-{1-[5-(4-tert-butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoicacid 1) Synthesis of1-[5-(4-tert-butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethanone

2-Oxopropanal benzylhydrazone (2.314 mmol, 408 mg) synthesized in thesame manner as in Reference Synthetic Examples 1 and 2 and(4-tert-butylphenyl)(oxo)acetaldehyde (1.929 mmol, 366.9 mg) synthesizedin Reference Synthetic Example 4 were dissolved in acetic acid (9 mL)and stirred at 100° C. for about 6 hours. Then, the solvent wasevaporated, and the residue was dried by means of a vacuum pump andpurified by silica gel column chromatography (n-hexane/AcOEt=3/1, and4/1) to give the desired product as a yellow solid (74.1 mg, yield 11%).

³H-NMR (ppm in CDCl₃)

δ 8.15 (s, 1H), 7.43-7.40 (multi, 2H), 7.30-7.25 (multi, 5H), 7.06-7.03(multi, 2H), 5.34 (s, 2H), 2.60 (s, 3H), 1.32 (s, 9H).

LC-MS (ESI) 348 (M⁺).

2) Synthesis of4-{[(2-{1-[5-(4-tert-butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[5-(4-tert-Butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethanone(0.218 mmol, 76 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.218mmol, 46 mg) were stirred with dimethylformamide (3.5 mL) and threedrops of concentrated hydrochloric acid at room temperature for 22hours. After addition of water, the precipitated yellow solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. The resulting solid was stirred with chloroform/n-hexanefor a while, then recovered by filtration and dried by means of a vacuumpump to give the desired product as a pale yellow solid (83 mg, yield70%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.94 (br.s, 1H), 10.36-10.34 (br.s, 1H), 8.90 (s, 1H), 7.94-7.85(multi, 4H), 7.56-7.47 (multi, 2H), 7.39-7.21 (multi, 5H), 7.09-6.95(multi, 2H), 5.34 and 5.29 (sx2, 2H), 2.47 and 2.40 (sx2, 3H), 1.33 and1.30 (sx2, 9H).

LC-MS (ESI) 541 (M⁺).

Synthetic Example 9 Synthesis of4-{[(2-{1-[(5-(3,4-dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid 1) Synthesis of1-[5-(3,4-dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (8.18 mmol, 819 mg) synthesized inReference Synthetic Example 1 and (3,4-dimethylphenyl)(oxo)acetaldehyde(7.57 mmol, 1.227 g) synthesized in Reference Synthetic Example 5 weredissolved in acetic acid (30 mL) and stirred at 100° C. for about 5hours. Then, the solvent was evaporated, and the residue was dried bymeans of a vacuum pump and subjected to silica gel column chromatography(n-hexane/AcOEt=2/1, and 4/1) to give the crude product. The crudeproduct was stirred with CHCl₃/n-hexane for a while, and then recoveredby filtration. The filtered solid was combined with a solid obtained bysilica gel thin layer chromatography purification (n-hexane/AcOEt=4/1)of the filtrate to give the desired product as an orange solid (237.5mg, yield 13%).

¹H-NMR (ppm in CDCl₃)

δ 8.13 (br.s, 1H), 7.23-7.15 (multi, 3H), 3.88 (s, 3H), 2.58 (s, 3H),2.34-2.31 (multi, 6H).

LC-MS (ESI) 244 (M⁺).

2) Synthesis of4-{[(2-{1-[5-(3,4-dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[5-(3,4-Dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone(0.2423 mmol, HPLC purity 84.3%, 70.2 mg) and4-hydrazinocarbonothioylaminobenzoic acid (0.2423 mmol, 51.2 mg) werestirred with dimethylformamide (3 mL) and three drops of concentratedhydrochloric acid at room temperature for 8.5 hours. After addition ofwater, the precipitated yellow solid was recovered by filtration, washedwith water and dried by means of a vacuum pump. The resulting solid wasstirred with chloroform/n-hexane for a while, then recovered byfiltration and dried by means of a vacuum pump to give the desiredproduct as a pale yellow solid (72.3 mg, yield 68%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.84 (br.s, 1H), 10.33 (s, 1H), 8.82 and 8.32 (sx2, 1H), 7.94-7.83(multi, 4H), 7.32-7.23 (multi, 3H), 3.81 and 3.79 (sx2, 3H), 2.46 and2.39 (sx2, 3H), 2.30-2.29 (multi, 6H).

LC-MS (ESI) 437 (M⁺).

Synthetic Example 10 Synthesis of4-{[(2-{1-[5-(4-n-pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid 1) Synthesis of1-[5-(4-n-pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (8.6 mmol, 861 mg) synthesized inReference Synthetic Example 1 and (4-n-pentylphenyl)(oxo)acetaldehyde(8.6 mmol, 1.757 g) synthesized in Reference Synthetic Example 6 weredissolved in acetic acid (30 mL) and stirred at 100° C. for about 5hours. Then, the solvent was evaporated, and the residue was dried bymeans of a vacuum pump and purified by silica gel column chromatography(n-hexane/AcOEt=2/1, and 4/1) to give the desired product as an orangesolid (252.5 mg, yield 10.3%, crude).

¹H-NMR (ppm in CDCl₃)

δ 8.16 (br.s, 1H), 7.37 (ABq, J=8.3 Hz, 2H), 7.29 (ABq, J=8.3 Hz, 2H),3.90 (s, 3H), 2.70-2.62 (multi, 2H), 2.58 (s, 3H), 1.70-1.60 (multi,2H), 1.39-1.32 (multi, 4H), 0.93-0.87 (multi, 3H).

LC-MS (ESI) 286 (M⁺).

2) Synthesis of4-{[(2-{1-[5-(4-n-pentylphenyl)-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[5-(4-n-Pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone(0.2381 mmol, HPLC purity 86.3%, 79.0 mg) and4-hydrazinocarbonothioylaminobenzoic acid (0.2381 mmol, 50.3 mg) werestirred with dimethylformamide (3 mL) and three drops of concentratedhydrochloric acid at room temperature for 8.5 hours. After addition ofwater, the precipitated yellow solid was recovered by filtration, washedwith water and dried by means of a vacuum pump. The resulting solid wasstirred with chloroform/n-hexane for a while, then recovered byfiltration and dried by means of a vacuum pump to give the desiredproduct as a pale yellow solid (86.4 mg, yield 76%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.90 (br.s, 1H), 10.34 (s, 1H), 8.85 (s, 1H), 7.94-7.84 (multi, 4H),7.48-7.32 (multi, 4H), 3.82 and 3.80 (sx2, 3H), 2.65-2.60 (multi, 2H),2.46 and 2.39 (sx2, 3H), 1.64-1.57 (multi, 2H), 1.34-1.30 (multi, 4H),0.90-0.86 (multi, 3H).

LC-MS (ESI) 479 (M⁺).

Synthetic Example 11 Synthesis of4-{[(2-{1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid 1) Synthesis of1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (8.540 mmol, 855 mg) synthesized inReference Synthetic Example 1 and(4-trifluoromethylphenyl)(oxo)acetaldehyde (6.432 mmol, 1.3 g)synthesized in Reference Synthetic Example 7 were dissolved in aceticacid (30 mL) and stirred at 100° C. for about 5 hours. Then, the solventwas evaporated, and the residue was dried by means of a vacuum pump andpurified by silica gel column chromatography (n-hexane/AcOEt=2/1, and4/1) to give the desired product as an orange solid (157.3 mg, yield8.6%).

¹H-NMR (ppm in CDCl₃)

δ 8.28 (s, 1H), 7.75 (ABq, J=8.3 Hz, 2H), 7.62 (ABq, J=8.3 Hz, 2H), 3.95(s, 3H), 2.59 (s, 3H).

LC-MS (ESI) 284 (M⁺).

2) Synthesis of4-{[(2-{1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone(0.1694 mmol, HPLC purity 80%, 60.2 mg) and4-hydrazinocarbonothioylaminobenzoic acid (0.1694 mmol, 35.8 mg) werestirred with dimethylformamide (3 mL) and three drops of concentratedhydrochloric acid at room temperature for 8.5 hours. After addition ofwater, the precipitated yellow solid was recovered by filtration, washedwith water and dried by means of a vacuum pump. Chloroform/n-hexane wasadded to the resulting solid, and the precipitated solid was recoveredby filtration and dried by means of a vacuum pump to give the desiredproduct as a pale yellow solid (72.2 mg, yield 89%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.93 (br.s, 1H), 10.36 and 10.35 (br.sx2, 1H), 9.14 (s, 1H),7.95-7.80 (multi, 8H), 3.88 (s, 3H), 2.47 and 2.41 (sx2, 3H).

LC-MS (ESI) 477 (M⁺).

Synthetic Example 12 Synthesis of4-[(2-{(1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]benzoicacid 1) Synthesis of methyl4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[5-(3,4-Dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.365 mmol, 105.8 mg), 4-hydrazinocarbonylmethyl benzoate (0.365 mmol,70.9 mg) and p-tosylic acid monohydrate (30 mol %, 18.9 mg) weredissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about19 hours. The reactor was cooled to room temperature, and theprecipitated solid was recovered by filtration, dried by means of avacuum pump and purified by silica gel thin layer chromatography(chloroform/methanol 10/1) to give the desired product as a white solid(21.7 mg, yield 14%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.39 (br.s, 1H), 9.66 (br.s, 1H), 8.10 (ABq, J=8.3 Hz, 2H), 8.04(ABq, J=8.3 Hz, 2H), 7.34 (br.s, 1H), 7.28 (br.s, 2H), 3.90 (s, 3H),3.83 (s, 3H), 2.45 (s, 3H), 2.30 (s, 3H), 2.28 (s, 3H).

LC-MS (ESI) 420 (M⁺).

2) Synthesis of4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.051 mmol, 21.6 mg), methanol (2.0 mL) was added, and 1 M aqueoussodium hydroxide (5 eq., 0.257 mL) was added at room temperature. After30 minutes of stirring at room temperature and 1.5 hours of stirring at60° C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (5 eq., 0.257 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump to give the desired product as a yellow solid (17.5 mg,yield 84%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.35 (br.s, 1H), 9.69 (br.s, 1H), 8.07-7.96 (multi, 4H), 7.88-7.26(multi, 3H), 3.82 (s, 3H), 2.45 (s, 3H), 2.30 (s, 3H), 2.28 (s, 3H).

LC-MS (ESI) 406 (M⁺).

Synthetic Example 13 Synthesis of4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of methyl4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[4-Hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethanone(0.309 mmol, 102.4 mg), 4-hydrazinocarbonylmethyl benzoate (0.309 mmol,59.9 mg) and p-tosylic acid monohydrate (30 mol %, 15.9 mg) weredissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about20 hours. The reactor was cooled to room temperature, and theprecipitated solid was recovered by filtration and dried by means of avacuum pump to give the desired product as a white solid (87.9 mg, yield62%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.27 (br.s, 1H), 9.94 (br.s, 1H), 8.10-8.05 (multi, 4H), 7.48 (ABq,J=8.1 Hz, 2H), 7.34 (ABq, J=8.1 Hz, 2H), 3.90 (s, 3H), 3.84 (s, 3H),2.63 (t, J=7.1 Hz, 2H), 2.44 (s, 3H), 1.62 (multi, 2H), 1.33-1.32(multi, 4H), 0.88 (t, J=7.1 Hz, 3H).

LC-MS (ESI) 462 (M⁺).

2) Synthesis of4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.121 mmol, 66.5 mg), methanol (3.5 mL) was added, and 1 M aqueoussodium hydroxide (5 eq., 0.605 mL) was added at room temperature. After30 minutes of stirring at room temperature and 1.5 hours of stirring at60° C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (5 eq., 0.605 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump to give the desired product as a yellow solid (40.4 mg,yield 74%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.36 (br.s, 1H), 9.69 (br.s, 1H), 8.07 (ABq, J=8.3 Hz, 2H), 8.01(ABq, J=8.3 Hz, 2H), 7.48 (ABq, J=8.0 Hz, 2H), 7.34 (ABq, J=8.0 Hz, 2H),3.84 (s, 3H), 2.63 (t, J=7.7 Hz, 2H), 2.45 (s, 3H), 1.62 (multi, 2H),1.33-1.32 (multi, 4H), 0.88 (t, J=6.8 Hz, 3H).

LC-MS (ESI) 448 (M⁺).

Synthetic Example 14 Synthesis of4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoicacid 1) Synthesis of methyl4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate

1-[4-Hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone(0.231 mmol, 82.1 mg), 4-hydrazinocarbonylmethyl benzoate (0.231 mmol,44.9 mg) and p-tosylic acid monohydrate (30 mol %, 11.9 mg) weredissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about20 hours. The reactor was cooled to room temperature, and theprecipitated solid was recovered by filtration and dried by means of avacuum pump to give the desired product as a pale yellow solid (66.5 mg,yield 63%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.46 (br.s, 1H), 9.97 (br.s, 1H), 8.11 (ABq, J=8.6 Hz, 2H), 8.04(ABq, J=8.6 Hz, 2H), 7.89 (ABq, J=8.6 Hz, 2H), 7.84 (ABq, J=8.6 Hz, 2H),3.92 (s, 3H), 3.90 (s, 3H), 2.47 (s, 3H).

LC-MS (ESI) 460 (M⁺).

2) Synthesis of4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoicacid

To methyl4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate(0.116 mmol, 53.4 mg), methanol (2 mL) was added, and 1 M aqueous sodiumhydroxide (5 eq., 0.580 mL) was added at room temperature. After 30minutes of stirring at room temperature and 1 hour of stirring at 60°C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (5 eq., 0.580 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump to give the desired product as a yellow solid (37.7 mg,yield 73%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.43 (br.s, 1H), 9.98 (br.s, 1H), 8.07 (ABq, J=8.4 Hz, 2H), 8.01(ABq, J=8.4 Hz, 2H), 7.89 (ABq, J=8.3 Hz, 2H), 7.84 (ABq, J=8.3 Hz, 2H),3.92 (s, 3H), 2.47 and 2.42 (sx2, 3H).

LC-MS (ESI) 446 (M⁺).

Synthetic Example 15 Synthesis of4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoicacid 1) Synthesis of1-[4-hydroxy-1-methyl-5-(3-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (7.49 mmol, 750 mg) and(oxo)[3-trifluoromethylphenyl]acetaldehyde (7.0 mmol, 1.42 g)synthesized in Reference Synthetic Example 8 were dissolved in aceticacid (20 mL) and stirred at 100° C. for 4 hours. Then, the solvent wasevaporated, and the residue was dried by means of a vacuum pump andpurified by silica gel column chromatography (n-hexane/ethylacetate=2/1) and then by silica gel thin layer chromatography(chloroform/methanol=30/1) to give the desired product as a reddishyellow liquid (221 mg, yield 11%).

¹H-NMR (ppm in CDCl₃)

δ 8.26 (s, 1H), 7.70-7.60 (multi, 4H), 3.93 (s, 3H), 2.59 (s, 3H).

LC-MS (ESI) 284 (M⁺).

2) Synthesis of methyl4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate

1-[4-Hydroxy-1-methyl-5-(3-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone(0.502 mmol, 142.7 mg), 4-hydrazinocarbonylmethyl benzoate (0.502 mmol,97.5 mg) and p-tosylic acid monohydrate (30 mol %, 26.0 mg) weredissolved in isopropyl alcohol (13 mL) and stirred at 100° C. for about11 hours. The reactor was cooled to room temperature, and theprecipitated solid was recovered by filtration, dried by means of avacuum pump and purified by silica gel thin layer chromatography(chloroform/methanol=10/1) and then by silica gel thin layerchromatography (n-hexane/ethyl acetate=1/2) to give the desired productas a yellow solid (36.7 mg, yield 16%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.46 (br.s, 1H), 9.94 (br.s, 1H), 8.10 (ABq, J=8.1 Hz, 2H), 8.05(ABq, J=8.1 Hz, 2H), 7.95-7.90 (multi, 2H), 7.81-7.77 (multi, 2H), 3.91(br.s, 6H), 2.47 (s, 3H).

LC-MS (ESI) 460 (M⁺).

3) Synthesis of4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoicacid

To methyl4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate(0.072 mmol, 33.1 mg), methanol (2 mL) was added, and 1 M aqueous sodiumhydroxide (5 eq., 0.360 mL) was added at room temperature. After 30minutes of stirring at room temperature and 1.5 hours of stirring at 60°C., the reactor was cooled to 0° C., and 1 M hydrochloric acid (5 eq.,0.360 mL) and water were added. The precipitated solid was recovered byfiltration, washed with water and dried by means of a vacuum pump togive the desired product as a yellow solid (17.6 mg, yield 55%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.40 (br.s, 1H), 9.99 (br.s, 1H), 8.06-7.69 (multi, 8H), 3.91 and3.89 (br.sx2, 3H), 2.47 and 2.39 (br.sx2, 3H).

LC-MS (ESI) 446 (M⁺).

Synthetic Example 16 Synthesis of4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (7.29 mmol, 730 mg) and(3,5-dimethylphenyl)(oxo)acetaldehyde (7.29 mmol, 1.18 g) synthesized inReference Synthetic Example 10 were dissolved in acetic acid (25 mL) andstirred at 100° C. for 5 hours. Then, the solvent was evaporated, andthe residue was dried by means of a vacuum pump and purified by silicagel column chromatography (n-hexane/ethyl acetate=3/1) and then bysilica gel thin layer chromatography (n-hexane/ethyl acetate=3/1) togive the desired product as an orange liquid (93 mg, yield 5%).

¹H-NMR (ppm in CDCl₃)

δ 8.15 (s, 1H), 7.05 (br.s, 3H), 3.88 (s, 3H), 2.58 (s, 3H), 2.37 (s,6H).

LC-MS (ESI) 244 (M⁺).

2) Synthesis of methyl4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[5-(3,5-Dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.120 mmol, 29.3 mg) and 4-hydrazinocarbonylmethyl benzoate (0.120mmol, 23.3 mg) were dissolved in dimethylformamide (5 mL) and stirred at110° C. for 23 hours. Then, the reactor was cooled to room temperature,and the solvent was evaporated with a centrifugal evaporator. Theresidue was dried and purified by silica gel thin layer chromatography(chloroform/methanol=10/1) to give the desired product as a yellow solid(23.4 mg, yield 46%).

LC-MS (ESI) 420 (M⁺).

3) Synthesis of4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[(5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.015 mmol, 6.5 mg), methanol (1 mL) was added, and 1 M aqueous sodiumhydroxide (5 eq., 0.077 mL) was added at room temperature. After 20minutes of stirring at room temperature and 1.5 hours of stirring at 60°C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (5 eq., 0.077 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump, and the residue was further purified by silica gel thinlayer chromatography (chloroform/methanol=10/1). After addition ofchloroform/n-hexane, the precipitated solid was recovered by filtrationand dried to give the desired product as a yellow solid (1.7 mg, yield27%).

LC-MS (MSI) 406 (M⁺).

Synthetic Example 17 Synthesis of4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of1-[5-(4-isopropylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (10.44 mmol, 1.05 g) and(4-isopropylphenyl)(oxo)acetaldehyde (10.44 mmol, 1.84 g) synthesized inReference Synthetic Example 12 were dissolved in acetic acid (37 mL) andstirred at 100° C. for 4.5 hours. Then, the solvent was evaporated, andthe residue was dried by means of a vacuum pump and purified by silicagel column chromatography (n-hexane/ethyl acetate=3/1) and then bysilica gel thin layer chromatography (n-hexane/ethyl acetate=3/1) togive the desired product as an orange solid (113 mg, yield 4%).

¹H-NMR (ppm in CDCl₃)

δ 8.15 (s, 1H), 7.39 (ABq, J=8.3 Hz, 2H), 7.34 (ABq, J=8.3 Hz, 2H), 3.90(s, 3H), 2.96 (sept, J=6.9 Hz, 1H), 2.58 (s, 3H), 1.28 (d, J=6.9 Hz,6H).

LC-MS (ESI) 258 (M⁺).

2) Synthesis of methyl4-[(2-{(1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[5-(4-Isopropylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.170 mmol, 44.0 mg) and 4-hydrazinocarbonylmethyl benzoate (0.170mmol, 33.1 mg) were dissolved in dimethylformamide (5.5 mL) and stirredat 110° C. for 23 hours. Then, the reactor was cooled to roomtemperature, and the solvent was evaporated with a centrifugalevaporator. The residue was dried, and chloroform was added. Theprecipitated solid was recovered by filtration to give the desiredproduct as a yellow solid (39.1 mg, yield 53%).

LC-MS (ESI) 434 (M⁺).

3) Synthesis of4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]benzoate(0.037 mmol, 16.0 mg), methanol (3 mL) was added, and 1 M aqueous sodiumhydroxide (5 eq., 0.184 mL) was added at room temperature. After 15minutes of stirring at room temperature and 1.5 hours of stirring at 60°C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (5 eq., 0.184 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump, and the residue was further purified by silica gel thinlayer chromatography (chloroform/methanol=10/1). After addition ofchloroform/n-hexane, the precipitated solid was dried to give thedesired product as a yellow solid (6.8 mg, yield 44%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.33 (br.s, 1H), 9.70 (br.s, 1H), 8.09-7.93 (multi, 4H), 7.51-7.38(multi, 4H), 3.86 and 3.84 (sx2, 3H), 2.99-2.94 (multi, 1H), 2.45 and2.43 (sx2, 3H), 1.26 (d, J=6.9 Hz, 6H).

LC-MS (ESI) 420 (M⁺).

Synthetic Example 18 Synthesis of4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (11.60 mmol, 1.16 g) and(4-isobutylphenyl)(oxo)acetaldehyde (11.60 mmol, 2.21 g) synthesized inReference Synthetic Example 15 were dissolved in acetic acid (38 mL) andstirred at 100° C. for 4.5 hours. Then, the solvent was evaporated, andthe residue was dried by means of a vacuum pump and purified by silicagel column chromatography (n-hexane/ethyl acetate=3/1), then by silicagel thin layer chromatography (chloroform) and by silica gel thin layerchromatography (n-hexane/ethyl acetate=3/1) to give the desired productas a brown solid (154 mg, yield 50).

¹H-NMR (ppm in CDCl₃)

δ 8.17 (s, 1H), 7.37 (ABq, J=8.3 Hz, 2H), 7.26 (ABq, J=8.3 Hz, 2H), 3.90(s, 3H), 2.58 (s, 3H), 2.52 (d, J=6.9 Hz, 2H), 1.91 (sept, J=6.9 Hz,1H), 0.94 (d, J=6.9 Hz, 6H).

LC-MS (ESI) 272 (M⁺).

2) Synthesis of methyl4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[4-Hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone(0.353 mmol, 96.0 mg) and 4-hydrazinocarbonylmethyl benzoate (0.353mmol, 68.5 mg) were dissolved in dimethylformamide (7 mL) and stirred at110° C. for 23 hours. Then, the reactor was cooled to room temperature,and the solvent was evaporated with a centrifugal evaporator. Theresidue was dried, and chloroform was added. The precipitated solid wasrecovered by filtration to give the desired product as a yellow solid(93.2 mg, yield 59%).

LC-MS (ESI) 448 (M⁺).

3) Synthesis of(4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.129 mmol, 57.7 mg), methanol (2.5 mL) was added, and 1 M aqueoussodium hydroxide (5 eq., 0.643 mL) was added at room temperature. After15 minutes of stirring at room temperature and 1.5 hours of stirring at60° C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (Seq., 0.643 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump, and the residue was further purified by silica gel thinlayer chromatography (chloroform/methanol=10/1). After addition ofchloroform/n-hexane, the precipitated solid was dried to give thedesired product as a yellow solid (25.6 mg, yield 46%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.34 (s, 1H), 9.72 (s, 1H), 8.10-7.95 (multi, 4H), 7.50-7.46 (multi,2H), 7.34-7.30 (multi, 2H), 3.87 and 3.84 (sx2, 3H), 2.45 (s, 3H), 1.90(sept, J=6.8 Hz, 1H), 0.91 (d, J=6.8 Hz, 6H).

LC-MS (ESI) 434 (M⁺).

Synthetic Example 19 Synthesis of4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-syl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (10.5.6 mmol, 1.06 g) and(3-bromo-4-fluorophenyl)(oxo)acetaldehyde (10.56 mmol, 2.44 g)synthesized in Reference Synthetic Example 9 were dissolved in aceticacid (37 mL) and stirred at 100° C. for 4.5 hours. Then, the solvent wasevaporated, and the residue was dried by means of a vacuum pump andpurified by silica gel column chromatography (n-hexane/ethylacetate=3/1), then by silica gel thin layer chromatography (chloroform)and by silica gel thin layer chromatography (n-hexane/ethyl acetate=3/1)to give the desired product as a brown solid (160 mg, yield 5%).

¹H-NMR (ppm in CDCl₃)

δ 8.21 (s, 1H), 7.69-7.66 (multi, 1H), 7.41-7.37 (multi, 1H), 7.27-7.22(multi, 1H), 3.89 (s, 3H), 2.58 (s, 3H).

LC-MS (ESI) 312, 314 (M⁺).

2) Synthesis of methyl4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[5-(3-Bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.269 mmol, 84.1 mg) and 4-hydrazinocarbonylmethyl benzoate (0.269mmol, 52.2 mg) were dissolved in dimethylformamide (7 mL) and stirred at110° C. for 23 hours. Then, the reactor was cooled to room temperature,and the solvent was evaporated with a centrifugal evaporator. Theresidue was dried, and chloroform was added. The precipitated solid wasrecovered by filtration to give the desired product as a yellow solid(60.1 mg, yield 46%).

LC-MS (ESI) 488 (M⁺).

3) Synthesis of4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.051 mmol, 24.9 mg), methanol (2.5 mL) was added, and 1 M aqueoussodium hydroxide (5 eq., 0.255 mL) was added at room temperature. After10 minutes of stirring at room temperature and 1.5 hours of stirring at60° C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (5 eq., 0.255 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump, and the residue was further purified by silica gel thinlayer chromatography (chloroform/methanol=10/1). After addition ofchloroform/n-hexane, the precipitated solid was dried to give thedesired product as a yellow solid (9.0 mg, yield 37%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.40 (s, 1H), 9.87 (s, 1H), 8.12-7.91 (multi, 5H), 7.62-7.52 (multi,2H), 3.86 (s, 3H), 2.45 and 2.43 (sx2, 3H).

LC-MS (ESI) 474 (M⁺).

Synthetic Example 20 Synthesis of4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (13.7 mmol, 1.37 g) and(4-ethylphenyl)(oxo)acetaldehyde (13.5 mmol, 2.19 g) synthesized inReference Synthetic Example 11 were dissolved in acetic acid (30 mL) andstirred at 100° C. for 6 hours. Then, the solvent was evaporated, andthe residue was dried by means of a vacuum pump and purified by silicagel column chromatography (n-hexane/ethyl acetate=3/1), then by silicagel thin layer chromatography (chloroform) and by silica gel thin layerchromatography (n-hexane/ethyl acetate=7/2) to give the desired productas a brown solid (255 mg, yield 8%).

¹H-NMR (ppm in CDCl₃)

δ 8.15 (s, 1H), 7.38 (ABq, J=8.4 Hz, 2H), 7.32 (ABq, J=8.4 Hz, 2H), 3.90(s, 3H), 2.70 (q, J=7.8 Hz, 2H), 2.58 (s, 3H), 1.28 (t, J=7.8 Hz, 3H).

LC-MS (ESI) 244 (M⁺).

2) Synthesis of methyl4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[5-(4-Ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.459mmol, 112.1 mg) and 4-hydrazinocarbonylmethyl benzoate (0.459 mmol, 89.1mg) were dissolved in dimethylformamide (9 mL) and stirred at 110° C.for 23 hours. Then, the reactor was cooled to room temperature, and thesolvent was evaporated with a centrifugal evaporator. The residue wasdried, and chloroform was added. The precipitated solid was recovered byfiltration to give the desired product as a yellow solid (130.5 mg,yield 68%).

LC-MS (ESI) 420 (M⁺).

3) Synthesis of4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.172 mmol, 72.4 mg), methanol (4 mL) was added, and 1 M aqueous sodiumhydroxide (5 eq., 0.861 mL) was added at room temperature. After 10minutes of stirring at room temperature and 2 hours of stirring at 60°C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (5 eq., 0.861 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump, and the residue was further purified by silica gel thinlayer chromatography (chloroform/methanol=10/1). After addition ofchloroform/n-hexane, the precipitated solid was dried to give thedesired product as a yellow solid (29.1 mg, yield 42%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.36 (s, 1H), 9.68 (s, 1H), 8.13-7.96 (multi, 4H), 7.50-7.35 (multi,4H), 3.87 and 3.84 (sx2, 3H), 2.72-2.64 (multi, 2H), 2.45 (s, 3H),1.26-1.21 (multi, 3H).

LC-MS (ESI) 406 (M⁺).

Synthetic Example 21 Synthesis of4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of1-[5-(4-n-propylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (19.36 mmol, 1.94 g) andoxo(4-n-propylphenyl)acetaldehyde (19.0 mmol, 3.35 g) synthesized inReference Synthetic Example 13 were dissolved in acetic acid (42 mL) andstirred at 100° C. for 6 hours. Then, the solvent was evaporated, andthe residue was dried by means of a vacuum pump and purified by silicagel column chromatography (n-hexane/ethyl acetate=3/1), then by silicagel thin layer chromatography (chloroform) and by silica gel thin layerchromatography (n-hexane/ethyl acetate=7/2) to give the desired productas a brown solid (304 mg, yield 6%).

¹H-NMR (ppm in CDCl₃)

δ 8.15 (s, 1H), 7.37 (ABq, J=8.3 Hz, 2H), 7.29 (ABq, J=8.3 Hz, 2H), 3.90(s, 3H), 2.64 (t, J=7.5 Hz, 2H), 2.58 (s, 3H), 1.68 (q, J=7.2 Hz, 2H),0.97 (t, J=7.2 Hz, 3H).

LC-MS (ESI) 258 (M⁺).

2) Synthesis of methyl4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[4-Hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethanone(0.445 mmol, 115.0 mg) and 4-hydrazinocarbonylmethyl benzoate (0.445mmol, 86.5 mg) were dissolved in dimethylformamide (9 mL) and stirred at110° C. for 23 hours. Then, the reactor was cooled to room temperature,and the solvent was evaporated with a centrifugal evaporator. Theresidue was dried, and chloroform was added. The precipitated solid wasrecovered by filtration to give the desired product as a yellow solid(143.3 mg, yield 74%).

LC-MS (ESI) 434 (M⁺).

3) Synthesis of4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.166 mmol, 72.2 mg), methanol was added, and 1 M aqueous sodiumhydroxide (5 eq., 0.831 mL) was added at room temperature. After 10minutes of stirring at room temperature and 2 hours of stirring at 60°C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (5 eq., 0.831 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump, and the residue was further purified by silica gel thinlayer chromatography (chloroform/methanol=10/1). After addition ofchloroform/n-hexane, the precipitated solid was recovered by filtrationand dried to give the desired product as a yellow solid (47.1 mg, yield670).

¹H-NMR (ppm in DMSO-d₆)

δ 11.36 (s, 1H), 9.69 (s, 1H), 8.12-7.96 (multi, 4H), 7.50-7.45 (multi,2H), 7.39-7.33 (multi, 2H), 3.87 and 3.84 (sx2, 3H), 2.66-2.59 (multi,2H), 2.45 (s, 3H), 1.71-1.58 (multi, 2H), 0.96-0.91 (multi, 3H).

LC-MS (ESI) 420 (M⁺).

Synthetic Example 22 Synthesis of4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone

2-Oxopropanal methylhydrazone (16.1 mmol, 1.62 g) and(4-n-hexylphenyl)(oxo)acetaldehyde (16 mmol, 4.57 g) synthesized inReference Synthetic Example 14 were dissolved in acetic acid (35 mL) andstirred at 100° C. for 6 hours. Then, the solvent was evaporated, andthe residue was dried by means of a vacuum pump and purified by silicagel column chromatography (n-hexane/ethyl acetate=3/1), then by silicagel thin layer chromatography (chloroform) and by silica gel thin layerchromatography (n-hexane/ethyl acetate=7/2) to give the desired productas a brown solid (308 mg, yield 6%).

¹H-NMR (ppm in CDCl₃)

δ 8.16 (s, 1H), 7.37 (ABq, J=8.1 Hz, 2H), 7.29 (ABq, J=8.1 Hz, 2H), 3.90(s, 3H), 2.65 (t, J=7.8 Hz, 2H), 2.58 (s, 3H), 1.64-1.62 (multi, 2H),1.41-1.28 (multi, 6H), 0.92-0.87 (multi, 3H).

LC-MS (ESI) 300 (M⁺).

2) Synthesis of methyl4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.431 mmol, 129.6 mg) and 4-hydrazinocarbonylmethyl benzoate (0.431mmol, 83.8 mg) were dissolved in dimethylformamide (8 mL) and stirred at110° C. for 23 hours. Then, the reactor was cooled to room temperature,and the solvent was evaporated with a centrifugal evaporator. Theresidue was dried, and chloroform was added. The precipitated solid wasrecovered by filtration to give the desired product as a yellow solid(125.1 mg, yield 61%).

LC-MS (ESI) 476 (M⁺).

3) Synthesis of4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.158 mmol, 75.2 mg), methanol was added, and 1 M aqueous sodiumhydroxide (5 eq., 0.789 mL) was added at room temperature. After 10minutes of stirring at room temperature and 2 hours of stirring at 60°C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (5 eq., 0.789 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water and dried by means of avacuum pump, and the residue was further purified by silica gel thinlayer chromatography (chloroform/methanol=10/1). After addition ofchloroform/n-hexane, the precipitated solid was dried to give thedesired product as a yellow solid (29.4 mg, yield 40%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.36 (s, 1H), 9.69 (s, 1H), 8.13-7.95 (multi, 4H), 7.49-7.45 (multi,2H), 7.38-7.33 (multi, 2H), 3.87 and 3.84 (sx2, 3H), 2.67-2.61 (multi,2H), 2.45 (s, 3H), 1.66-1.56 (multi, 2H), 1.36-1.24 (multi, 6H),0.89-0.85 (multi, 3H).

LC-MS (ESI) 462 (M⁺).

Synthetic Example 23 Synthesis of4-({[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonothioyl}amino)benzoicacid

1-[4-Hydroxy-1-methyl-5-(3-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone(0.229 mmol, 65.0 mg) and 4-hydrazinocarbonothioylaminobenzoic acid(0.229 mmol, 48.3 mg) were stirred with dimethylformamide (2.5 mL) andthree drops of concentrated hydrochloric acid at room temperature for 24hours. After addition of water, the precipitated yellow solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. Chloroform/n-hexane was added to the resulting solid, andthe precipitated solid was recovered by filtration and dried by means ofa vacuum pump to give the desired product as a yellow solid (74.7 mg,yield 68%).

¹H-NMR (ppm in DMSO-d₆)

δ 10-36 and 10.33 (br.sx2, 1H), 9.12 (s, 1H), 7.95-7.77 (multi, 8H),3.86 (s, 3H), 2.41 (s, 3H).

LC-MS (ESI) 477 (M⁺).

Synthetic Example 24 Synthesis of4-{[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[5-(3,5-Dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.122 mmol, 29.9 mg) and 4-hydrazinocarbonothioylaminobenzoic acid(0.122 mmol, 25.9 mg) were stirred with dimethylformamide (2 mL) and twodrops of concentrated hydrochloric acid at room temperature for 24hours. After addition of water, the precipitated yellow solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. The resulting solid was stirred with chloroform/n-hexanefor a while, then recovered by filtration and dried by means of a vacuumpump to give the desired product as a pale yellow solid (34.7 mg, yield65%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.87 (br.s, 1H), 10.33 and 10.32 (br.sx2, 1H), 8.84 (s, 1H), 7.93(ABq, J=8.1 Hz, 2H), 7.84 (ABq, J=8.1 Hz, 2H), 7.16-7.14 (multi, 2H),7.06 (br.s, 1H), 3.81 and 3.79 (sx2, 3H), 2.46 and 2.39 (sx2, 3H),2.35-2.31 (multi, 6H).

LC-MS (ESI) 437 (M⁺).

Synthetic Example 25 Synthesis of4-{[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[4-Hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone(0.116 mmol, 29.9 mg) and 4-hydrazinocarbonothioylaminobenzoic acid(0.116 mmol, 24.5 mg) were stirred with dimethylformamide (2 mL) and twodrops of concentrated hydrochloric acid at room temperature for 24hours. After addition of water, the precipitated yellow solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. The resulting solid was stirred with chloroform/n-hexanefor a while, then recovered by filtration and dried by means of a vacuumpump to give the desired product as a pale yellow solid (37.7 mg, yield72%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.90 (br.s, 1H), 10.35 and 10.33 (br.sx2, 1H), 8.85 (s, 1H), 7.93(ABq, J=8.6 Hz, 2H), 7.85 (ABq, J=8.6 Hz, 2H), 7.47 (ABq, J=8.1 Hz, 2H),7.39 (ABq, J=8.1 Hz, 2H), 3.83 and 3.81 (sx2, 3H), 2.95 (sept, J=6.9 Hz,1H), 2.46 and 2.39 (sx2, 3H), 1.27-1.24 (multi, 6H).

LC-MS (ESI) 451 (M⁺).

Synthetic Example 26 Synthesis of4-{[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[4-Hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone(0.179 mmol, 48.8 mg) and 4-hydrazinocarbonothioylaminobenzoic acid(0.179 mmol, 37.9 mg) were stirred with dimethylformamide (2.5 mL) andthree drops of concentrated hydrochloric acid at room temperature for24.5 hours. After addition of water, the precipitated yellow solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. The resulting solid was stirred with chloroform/n-hexanefor a while, then recovered by filtration and dried by means of a vacuumpump to give the desired product as a pale yellow solid (62.6 mg, yield75%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.87 (br.s, 1H), 10.34 (br.s, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.6 Hz,2H), 7.85 (ABq, J=8.6 Hz, 2H), 7.46 (ABq, J=8.3 Hz, 2H), 7.30 (ABq,J=8.3 Hz, 2H), 3.83 and 3.81 (sx2, 3H), 2.54-2.51 (multi, 2H), 2.46 and2.39 (sx2, 3H), 1.89 (sept, J=6.8 Hz, 1H), 0.92-0.89 (multi, 6H).

LC-MS (ESI) 465 (M⁺).

Synthetic Example 27 Synthesis of4-{[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[5-(3-Bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.139 mmol, 43.6 mg) and 4-hydrazinocarbonothioylaminobenzoic acid(0.139 mmol, 29.4 mg) were stirred with dimethylformamide (2.5 mL) andthree drops of concentrated hydrochloric acid at room temperature for24.5 hours. After addition of water, the precipitated yellow solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. The resulting solid was stirred with chloroform/n-hexanefor a while, then recovered by filtration and dried by means of a vacuumpump to give the desired product as a yellow solid (51.8 mg, yield 74%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.35 and 10.32 (br.sx2, 1H), 9.08 (s, 1H), 7.98-7.79 (multi, 5H),7.65-7.51 (multi, 2H), 3.83 (s, 3H), 2.46 and 2.39 (sx2, 3H).

LC-MS (ESI) 505, 507 (M⁺).

Synthetic Example 28 Synthesis of4-{[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[5-(4-Ethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.159mmol, 38.8 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.159mmol, 33.6 mg) were stirred with dimethylformamide (2.3 mL) and threedrops of concentrated hydrochloric acid at room temperature for 23.5hours. After addition of water, the precipitated yellow solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. The resulting solid was stirred with chloroform/n-hexanefor a while, then recovered by filtration and dried by means of a vacuumpump to give the desired product as a pale yellow solid (50.6 mg, yield730).

¹H-NMR (ppm in DMSO-d₆)

δ 10.87 (br.s, 1H), 10.33 (br.s, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.7 Hz,2H), 7.85 (ABq, J=8.7 Hz, 2H), 7.46 (ABq, J=8.1 Hz, 2H), 7.36 (ABq,J=8.1 Hz, 2H), 3.82 and 3.80 (sx2, 3H), 2.67 (q, J=7.5 Hz, 2H), 2.46 and2.39 (sx2, 3H), 1.26-1.20 (multi, 3H).

LC-MS (ESI) 437 (M⁺).

Synthetic Example 29 Synthesis of4-{[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

1-[4-Hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethanone(0.157 mmol, 40.5 mg) and 4-hydrazinocarbonothioylaminobenzoic acid(0.157 mmol, 33.1 mg) were stirred with dimethylformamide (2.3 mL) andthree drops of concentrated hydrochloric acid at room temperature for23.5 hours. After addition of water, the precipitated yellow solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. The resulting solid was stirred with chloroform/n-hexanefor a while, then recovered by filtration and dried by means of a vacuumpump to give the desired product as a pale yellow solid (56.2 mg, yield79%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.32 (br.s, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.7 Hz, 2H), 7.85 (ABq,J=8.7 Hz, 2H), 7.46 (ABq, J=8.1 Hz, 2H), 7.34 (ABq, J=8.1 Hz, 2H), 3.82and 3.80 (sx2, 3H), 2.62 (t, J=7.7 Hz, 2H), 2.46 and 2.39 (sx2, 3H),1.70-1.57 (multi, 2H), 0.97-0.91 (multi, 3H).

LC-MS (ESI) 451 (M⁺).

Synthetic Example 30 Synthesis of4-{[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoicacid

1-[5-(4-n-Hexylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone(0.117 mmol, 35.1 mg) and 4-hydrazinocarbonothioylaminobenzoic acid(0.117 mmol, 24.7 mg) were stirred with dimethylformamide (2.3 mL) andthree drops of concentrated hydrochloric acid at room temperature for23.5 hours. After addition of water, the precipitated yellow solid wasrecovered by filtration, washed with water and dried by means of avacuum pump. The resulting solid was stirred with chloroform/n-hexanefor a while, then recovered by filtration and dried by means of a vacuumpump to give the desired product as a pale yellow solid (46.3 mg, yield80%).

¹H-NMR (ppm in DMSO-d₆)

δ 10.87 (br.s, 1H), 10.33 (br.s, 1H), 8.84 (s, 1H), 7.93 (ABq, J=8.6 Hz,2H), 7.84 (ABq, J=8.6 Hz, 2H), 7.45 (ABq, J=8.1 Hz, 2H), 7.33 (ABq,J=8.1 Hz, 2H), 3.82 and 3.80 (sx2, 3H), 2.63 (t, J=7.7 Hz, 2H), 2.46 and2.39 (sx2, 3H), 1.61 (multi, 2H), 1.30 (multi, 6H), 0.86 (multi, 3H).

LC-MS (ESI) 493 (M⁺).

Synthetic Example 31 Synthesis of4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]benzoicacid 1) Synthesis of methyl4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[5-(4-t-Butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.313mmol, 89.5 mg), 4-hydrazinocarbonylmethyl benzoate (0.313 mmol, 60.7 mg)and p-tosylic acid monohydrate (30 mol %, 16.1 mg) were dissolved inisopropyl alcohol (16 mL) and stirred at 100° C. for 19 hours. Thereactor was cooled to room temperature, and the solvent was evaporated.The resulting crude product was purified by silica gel columnchromatography (chloroform/methanol=10/1) and then by silica gel columnchromatography (n-hexane/ethyl acetate=1/2) to give the desired productas a yellow solid (16.8 mg, yield 12%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.39 (br.s, 1H), 9.60 (br.s, 1H), 8.10 (ABq, J=8.3 Hz, 2H), 8.04(ABq, J=8.3 Hz, 2H), 7.55 (ABq, J=8.1 Hz, 2H), 7.44 (ABq, J=8.1 Hz, 2H),4.12 (q, J=7.2 Hz, 2H), 3.90 (s, 3H), 2.46 (s, 3H), 1.34 (s, 9H), 1.29(t, J=7.2 Hz, 3H).

LC-MS (ESI) 462 (M⁺).

2) Synthesis of4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.032 mmol, 15.0 mg), methanol (1.5 mL) was added, and 1 M aqueoussodium hydroxide (0.162 mmol, 0.162 mL) was added at room temperature.After 30 minutes of stirring at room temperature and 1.25 hours ofstirring at 60° C., the reactor was cooled to 0° C., and 1 Mhydrochloric acid (0.162 mmol, 0.162 mL) and water were added. Theprecipitated solid was recovered by filtration, washed with water, driedby means of a vacuum pump and purified by silica gel thin layerchromatography (chloroform/methanol=10/1) to give the desired product asa yellow solid (6.4 mg, yield 44%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.33 (br.s, 1H), 9.64 (br.s, 1H), 8.06-7.94 (multi, 4H), 7.58-7.43(multi, 4H), 4.12 (q, J=7.5 Hz, 2H), 2.46 and 2.44 (sx2, 3H), 1.34 (s,9H), 1.27 (t, J=7.5 Hz, 3H).

LC-MS (ESI) 448 (M⁺).

Synthetic Example 32 Synthesis of4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of methyl4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[1-Benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethanone(0.610 mmol, 212.6 mg), 4-hydrazinocarbonylmethyl benzoate (0.610 mmol,118.5 mg) and p-tosylic acid monohydrate (30 mol %, 31.5 mg) weredissolved in isopropyl alcohol (20 mL) and stirred at 100° C. for 18hours. The reactor was cooled to room temperature, and the solvent wasevaporated. The resulting crude product was purified by silica gelcolumn chromatography (chloroform/methanol=10/1) and then by silica gelcolumn chromatography (n-hexane/ethyl acetate=1/2) to give the desiredproduct as a yellow solid (56.6 mg, yield 18%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.44 (br.s, 1H), 9.72 (br.s, 1H), 8.11 (ABq, J=8.1 Hz, 2H), 8.05(ABq, J=8.1 Hz, 2H), 7.49 (ABq, J=8.3 Hz, 2H), 7.37 (ABq, J=8.3 Hz, 2H),7.32-7.22 (multi, 3H), 6.99-6.97 (multi, 2H), 5.38 (s, 2H), 3.91 (s,3H), 2.46 (s, 3H), 1.30 (s, 9H).

LC-MS (ESI) 524 (M⁺).

2) Synthesis of4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.045 mmol, 23.5 mg), methanol was added, and 1 M aqueous sodiumhydroxide (0.224 mmol, 0.224 mL) was added at room temperature. After 30minutes of stirring at room temperature and 1.5 hours of stirring at 60°C., the reactor was cooled to 0° C., and 1 M hydrochloric acid (0.224mmol, 0.224 mL) and water were added. The precipitated solid wasrecovered by filtration, washed with water, dried by means of a vacuumpump and purified by silica gel thin layer chromatography(chloroform/methanol=10/1) to give the desired product as a yellow solid(15.8 mg, yield 69%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.41 (br.s, 1H), 9.74 (br.s, 1H), 8.06-6.97 (multi, 13H), 5.38 (s,2H), 2.46 (s, 3H), 1.30 (s, 9H).

LC-MS (ESI) 510 (M⁺).

Synthetic Example 33 Synthesis of methyl5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate

1-[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (38.0mg, 0.14 mmol) and methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate(27.9 mg, 0.14 mmol) were dissolved in dimethylformamide (2.0 mL) andstirred at 110° C. for 12 hours. After cooling, the solvent wasevaporated, and ethyl acetate was added to the resulting crude product.The precipitated solid was recovered by filtration to give 20.0 mg ofthe desired product as a pale yellow solid (yield 31%).

¹H-NMR (ppm in CDCl₃)

δ 7.78 (d, J=3.6 Hz, 1H), 7.42-7.52 (multi, 5H), 3.92 (s, 3H), 3.88 (s,3H), 2.45 (s, 3H), 1.36 (s, 9H).

LC-MS (ESI) 454 (M⁺).

Synthetic Example 34 Synthesis of5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylicacid

Methyl5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate(16.0 mg, 0.035 mmol) in methanol (1.5 mL) was stirred with 1 M aqueoussodium hydroxide (176 μL, 0.176 mmol) at room temperature for 17 hours.After the stirring, 1 M hydrochloric acid (176 μL, 0.176 mmol) wasadded, and the precipitated solid was recovered by filtration to give6.2 mg of the desired product as yellow crystals (yield 40%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.36 (br.s, 1H), 9.50 (br.s, 1H), 8.02 (d, J=4.5 Hz, 1H), 7.79 (d,J=4.5 Hz, 1H), 7.48-7.56 (multi, 4H), 3.84 (s, 3H), 2.45 (s, 3H), 1.33(s, 9H).

LC-MS (ESI) 440 (M⁺).

Synthetic Example 35 Synthesis of methyl4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.36mmol) synthesized in Reference Synthetic Example 33 and4-hydrazinocarbonylmethyl benzoate (70 mg, 0.36 mmol) were stirred indimethylformamide (3.6 mL) at 120° C. overnight. The reaction solutionwas partitioned between ethyl acetate-saturated aqueous ammoniumchloride, and the organic layer was washed with saturated aqueous sodiumchloride. The precipitated solid was recovered from the solution byfiltration to give the desired product as a pale yellow solid (58 mg,yield 36%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 3.91 (s, 3H), 7.43 (d, J=8.2 Hz, 2H), 7.71 (d, J=8.2 Hz,2H), 7.99-8.13 (m, 5H), 11.48 (s, 1H), 12.23 (s, 1H).

¹H-NMR (ppm in MeOH-d₄)

δ 1.34 (s, 9H), 2.48 (s, 3H), 3.95 (s, 3H), 7.39-8.16 m, 9H).

LC/MS (ES⁺) 451.

Synthetic Example 36 Synthesis of methyl4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.35mmol) synthesized in Reference Synthetic Example 34 and4-hydrazinocarbonylmethyl benzoate (68 mg, 0.35 mmol) were stirred indimethylformamide (3.6 mL) at 120° C. under heating overnight. Theresulting reaction solution was concentrated, and ethyl acetate/n-hexanewas added. The precipitated solid was recovered by filtration to givethe desired product as a pale yellow solid (141 mg, yield 87%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.91 (s, 3H), 7.64-7.73 (m, 2H), 8.05-8.13 (m, 6H), 11.55 (bs, 1H).

LC/MS (ES⁻) 461, 462, 464.

Synthetic Example 37 Synthesis of methyl4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene(100 mg, 0.35 mmol) synthesized in Reference Synthetic Example 35, thedesired product was obtained in the same manner as in Synthetic Example36 as a pale yellow solid (132 mg, yield 82%).

¹H-NMR (ppm in MeOH-d₄)

δ 2.49 (s, 3H), 3.95 (s, 3H), 7.64-7.67 (m, 2H), 7.88 (s, 1H), 8.03-8.04(m, 4H), 8.15-8.18 (m, 2H).

LC/MS (ES⁺) 463.

Synthetic Example 38 Synthesis of methyl2-nitro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}-hydrazino)carbonyl]benzoate

2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (80 mg, 0.29mmol) and methyl 2-nitro-4-hyrazinocarbonylbenzoate (69 mg, 0.29 mmol)were stirred in dimethylformamide (2.9 mL) at 120° C. under heatingovernight. The resulting reaction solution was concentrated, and ethylacetate/n-hexane was added. The precipitated solid was recovered byfiltration to give the desired product as a brown solid (92 mg, yield64%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 3.90 (s, 3H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.4 Hz,2H), 8.02-8.07 (m, 2H), 8.36 (d, J=7.4 Hz, 1H), 8.59 (s, 1H).

LC/MS (ES⁺) 496.

Synthetic Example 39 Synthesis of methyl5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate

2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (80 mg, 0.29mmol) and methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (58 mg, 0.29mmol) were stirred in dimethylformamide (2.9 mL) at 120° C. underheating overnight. The resulting reaction solution was concentrated, andchloroform/n-hexane was added. The precipitated solid was recovered byfiltration to give the desired product as a yellow solid (79 mg, yield60%).

¹H-NMR (ppm in MeOH-d₄)

δ 1.34 (s, 9H), 2.48 (s, 3H), 3.91 (s, 3H), 7.38-7.81 (m, 7H).

LC/MS (ES⁴) 457.

Synthetic Example 40 Synthesis of methyl4-[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate

2-(4-t-Butylphenyl)-3-hydroxy-4-formylthiophene (100 mg, 0.38 mmol)synthesized in Reference Synthetic Example 25 and4-hydrazinocarbonylmethyl benzoate (74 mg, 0.38 mmol) were stirred indimethylformamide (3.8 mL) at room temperature overnight. The reactionsolution was partitioned between ethyl acetate-water, and the organiclayer was washed with saturated aqueous sodium chloride. The resultingorganic layer was concentrated and purified by silica gel columnchromatography (chloroform) to give the desired product as a light brownsolid (74 mg, yield 46%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 3.91 (s, 3H), 7.44 (d, J=8.4 Hz, 2H), 7.69 (d, J=8.4 Hz,2H), 7.93-7.95 (m, 2H), 8.06-8.15 (m, 4H), 8.57 (s, 1H), 10.87 (s, 1H),12.40 (s, 1H).

LC/MS (ES⁺) 437.

Synthetic Example 41 Synthesis of methyl4-[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate

2-(3,4-Dichlorophenyl)-3-hydroxy-4-formylthiophene (104 mg, 0.38 mmol)synthesized in Reference Synthetic Example 26 and4-hydrazinocarbonylmethyl benzoate (74 mg, 0.38 mmol) were stirred indimethylformamide (3.8 mL) at room temperature overnight. Water wasadded to the reaction solution, and the precipitated solid was recoveredby filtration to give the desired product as a pale yellow solid (175mg, yield 100%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.91 (s, 3H), 7.65-7.72 (m, 2H), 7.96-8.14 (m, 7H), 8.62 (s, 1H),11.37 (bs, 1H).

LC/MS (ES⁺) 451, 452, 453.

Synthetic Example 42 Synthesis of4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

Methyl4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate(50 mg, 0.11 mmol) synthesized in Synthetic Example 35 was dissolved inmethanol (1.1 mL) and stirred with 1 M aqueous sodium hydroxide (0.55mL, 0.55 mmol) at 45° C. for 1.5 hours. After the stirring, 1 Mhydrochloric acid (0.55 mL, 0.55 mmol) was added, and the precipitatedpale yellow solid was recovered by filtration. The resulting solid waspurified by silica gel chromatography (chloroform:methanol=9:1). Theresulting solid was stirred with chloroform at room temperature andrecovered by filtration to give the desired product as a pale yellowsolid (11 mg, yield 23%).

¹H-NMR (ppm in MeOH-d₄)

δ 1.34 (s, 9H), 2.48 (s, 3H), 7.39-8.08 (m, 9H).

LC/MS (ES^(˜)9437.

Synthetic Example 43 Synthesis of4-[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoicacid

From methyl4-[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate(62 mg, 0.14 mmol) synthesized in Synthetic Example 40, the desiredproduct was obtained in the same manner as in Synthetic Example 42 as apale yellow solid (34 mg, yield 57%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 7.44 (d, J=8.4 Hz, 2H), 7.69 (d, J=8.4 Hz, 2H), 7.93 (s,1H), 8.03-8.09 (m, 4H), 8.58 (s, 1H), 10.88 (s, 1H), 12.38 (bs, 1H).

LC/MS (ES⁺) 423.

Synthetic Example 44 Synthesis of4-[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoicacid

From methyl4-[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate(120 mg, 0.27 mmol) synthesized in Synthetic Example 41, the desiredproduct was obtained in the same manner as in Synthetic Example 42 as apale yellow solid (44 mg, yield 37%).

¹H-NMR (ppm in DMSO-d₆)

δ 7.66-7.72 (m, 2H), 8.03-8.21 (m, 6H), 8.58 (s, 1H), 11.37 (bs, 1H).

Synthetic Example 45 Synthesis of4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

From methyl4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate(100 mg, 0.22 mmol) synthesized in Synthetic Example 36, the desiredproduct was obtained in the same manner as in Synthetic Example 42 as apale yellow solid (9 mg, yield 9%).

¹H-NMR (ppm in DMSO-d₆)

δ 7.64-7.73 (m, 2H), 8.01-8.12 (m, 6H).

¹H-NMR (ppm in MeOH-d₄)

δ 2.47 (s, 3H), 7.47-8.16 (m, 8H).

LC/MS (ES⁺) 449, 450, 451.

Synthetic Example 46 Synthesis of4-[(2-{(1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

From methyl4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate(100 mg, 0.22 mmol) synthesized in Synthetic Example 37, the desiredproduct was obtained in the same manner as in Synthetic Example 42 as acolorless solid (34 mg, yield 34%).

¹H-NMR (ppm in DMSO-d₆)

δ 7.75-7.78 (m, 2H), 8.00-8.15 (m, 7H), 11.51 (bs, 1H).

LC/MS (ES⁻) 447.

Synthetic Example 47 Synthesis of2-nitro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

From methyl2-nitro-4-[(2-{(1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate(60 mg, 0.12 mmol) synthesized in Synthetic Example 38, the desiredproduct was obtained in the same manner as in Synthetic Example 42 as ayellow solid (10 mg, yield 17%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.4 Hz, 2H),7.95-8.03 (m, 2H), 8.30 (d, J=8.0 Hz, 1H), 8.51 (s, 1H).

¹H-NMR (ppm in MeOH-d₄)

δ 1.34 (s, 9H), 2.49 (s, 3H), 7.39-8.46 (m, 8H).

LC/MS (ES⁺) 482.

Synthetic Example 48 Synthesis of5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid

From methyl5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate(72 mg, 0.16 mmol) synthesized in Synthetic Example 39, the desiredproduct was obtained in the same manner as in Synthetic Example 42 as ayellow solid (12 mg, yield 17%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 7.43 (d, J=8.5 Hz, 2H), 7.70 (d, J=8.5 Hz, 2H), 7.81 (d,J=4.1 Hz, 1H), 8.00 (s, 1H), 8.04 (d, J=4.1 Hz, 1H).

LC/MS (ES⁻) 442.

Synthetic Example 49 Synthesis of4-{[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonothioyl]amino}benzoicacid

2-(4-t-Butylphenyl)-3-hydroxy-4-formylthiophene (50 mg, 0.19 mmol)synthesized in Reference Synthetic Example 25 and4-hydrazinocarbonothioylaminobenzoic acid (40 mg, 0.19 mmol) werestirred with dimethylformamide (1.9 mL) and concentrated hydrochloricacid (0.1 mL) at room temperature for 12 hours. The reaction solutionwas partitioned between ethyl acetate and water, and the organic layerwas washed with saturated aqueous sodium chloride and dried overanhydrous sodium sulfate. The resulting organic layer was concentratedand purified by silica gel column chromatography (chloroform).Methanol/chloroform was added to the resulting crude product, and theprecipitated yellow solid was recovered by filtration to give thedesired product as a pale yellow solid (20 mg, yield 23%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 7.43 (d, J=8.5 Hz, 2H), 7.67 (d, J=8.5 Hz, 2H), 7.79 (d,J=8.5 Hz, 2H), 7.93-7.99 (m, 3H), 8.24 (s, 1H), 10.32 (s, 1H), 11.93 (s,1H).

LC/MS (ES⁺) 454.

Synthetic Example 50 Synthesis of4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoicacid

2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (31 mg, 0.11mmol) synthesized in Reference Synthetic Example 33 and4-hydrazinocarbonothioylaminobenzoic acid (23 mg, 0.11 mmol) werestirred with dimethylformamide (1.1 mL) and concentrated hydrochloricacid (0.05 mL) at room temperature for 30 hours. The reaction solutionwas partitioned between ethyl acetate and water, and the organic layerwas washed with saturated aqueous sodium chloride and dried overanhydrous sodium sulfate. The resulting organic layer was concentratedand purified by silica gel column chromatography (chloroform) to givethe desired product as a light brown solid (27 mg, yield 52%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 2.39 (s, 3H), 7.43 (d, J=8.5 Hz, 2H), 7.69 (d, J=8.5 Hz,2H), 7.86-7.95 (m, 5H), 10.40 (s, 1H), 11.08 (s, 1H).

LC/MS (ES⁺) 468.

Synthetic Example 51 Synthesis of4-{[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonothioyl]amino}benzoicacid

2-(3,4-Dichlorophenyl)-3-hydroxy-4-formylthiophene (52 mg, 0.19 mmol)synthesized in Reference Synthetic Example 26 and4-hydrazinocarbonothioylaminobenzoic acid (40 mg, 0.19 mmol) werestirred with dimethylformamide (1.9 mL) and concentrated hydrochloricacid (0.1 mL) at room temperature for 14 hours. Water was added to thereaction solution, and the precipitated solid was recovered byfiltration and dried. The crude product was stirred with chloroform atroom temperature and recovered by filtration to give the desired productas a pale yellow solid (58 mg, yield 65%).

¹H-NMR (ppm in DMSO-d₆)

δ 7.67-8.10 (m, 8H), 8.25 (s, 1H), 10.34 (s, 1H), 11.95 (s, 1H).

LC/MS (ES⁺) 465, 467, 469.

Synthetic Example 52 Synthesis of4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethyliden}hydrazino)carbonothioyl]amino}benzoicacid

From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (50 mg,0.17 mmol) synthesized in Reference Synthetic Example 34, the desiredproduct was obtained in the same manner as in Synthetic Example 51 as apale yellow solid (23 mg, yield 28%).

LC/MS (ES⁺) 480, 481, 482, 484.

Synthetic Example 53 Synthesis of4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethyliden}hydrazino)carbonothioyl]-amino}benzoicacid

From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (50mg, 0.17 mmol) synthesized in Reference Synthetic Example 35, thedesired product was obtained in the same manner as in Synthetic Example51 as a pale yellow solid (48 mg, 59%).

¹H-NMR (ppm in DMSO-d₆)

δ 2.41 (s, 3H), 7.74-8.11 (m, 9H), 10.49 (s, 1H), 11.18 (s, 1H).

LC/MS (ES⁺) 480.

Synthetic Example 54 Synthesis of4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoicacid 1) Synthesis of[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methanone

Oxo(phenyl)acetaldehyde methylhydrazone (5.46 mmol, 886 mg) synthesizedin Reference Synthetic Example 36 and (4-t-butylphenyl)(oxo)acetaldehyde(5 mmol, 951 mg) were dissolved in acetic acid (26 mL) and stirred at100° C. for about 2 hours. Then, the solvent was evaporated, and theresidue was recrystallized from chloroform/n-hexane to give the desiredproduct as a yellow solid (993 mg, yield 59%).

¹H-NMR (ppm in CDCl₃)

δ 9.04 (s, 1H), 8.51-8.48 (multi, 2H), 7.61-7.59 (multi, 1H), 7.55-7.44(multi, 6H), 3.98 (s, 3H), 1.37 (s, 9H).

LC-MS (ESI) 334 (M⁺).

2) Synthesis of methyl4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoate

[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methanone(0.299 mmol, 99.9 mg), 4-hydrazinocarbonylmethyl benzoate (0.299 mmol,58.0 mg) and p-tosylic acid monohydrate (30 mol %, 15.4 mg) weredissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about24 hours. Then, the reactor was cooled to room temperature, and theprecipitated solid was recovered by filtration and dried by means of avacuum pump to give the desired product as a pale yellow solid (119 mg,yield 78%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.29 (s, 1H), 9.85 (s, 1H), 8.03 (ABq, J=8.3 Hz, 2H), 7.84 (ABq,J=8.3 Hz, 2H), 7.62-7.55 (multi, 9H), 3.90 and 3.87 (sx2, 3H), 3.77 and3.73 (sx2, 3H), 1.34 and 1.32 (sx2, 9H).

LC-MS (ESI) 510 (M⁺).

3) Synthesis of4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoicacid

To methyl4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoate(0.196 mmol, 100 mg), methanol (4 mL) was added, and 1 M aqueous sodiumhydroxide (0.981 mmol, 0.981 mL) was added at room temperature. After 15minutes of stirring at room temperature and 1 hour of stirring at 60°C., the reactor was cooled to room temperature, and 1 M hydrochloricacid (0.981 mmol, 0.981 mL) and water were added. The precipitated solidwas recovered by filtration, washed with water and dried by means of avacuum pump to give the desired product as a yellow solid (93 mg, yield95%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.25 (s, 1H), 9.86 (s, 1H), 8.00 (ABq, J=8.3 Hz, 2H), 7.81 (ABq,J=8.3 Hz, 2H), 7.62-7.55 (multi, 9H), 3.77 and 3.73 (sx2, 3H), 1.3.4 and1.32 (sx2, 9H).

LC-MS (ESI) 496 (M⁺).

Synthetic Example 55 Synthesis of4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene]hydrazino}carbonyl)-N-methylbenzenesulfonamide

1-[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.228 mmol, 62 mg), 4-(hydrazinocarbonyl)-N-methylbenzenesulfonamide(0.228 mmol, 52 mg) and p-tosylic acid monohydrate (30 mol %, 11.8 mg)were dissolved in isopropyl alcohol (6 mL) and stirred at 100° C. for 19hours. Then, the solvent was evaporated, and the residue was purified bysilica gel thin layer chromatography (chloroform/methanol=10/1) to givethe desired product as a yellow solid (30.3 mg, yield 28%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.40 (s, 1H), 9.65 (s, 1H), 8.32 (s, 1H), 8.10 (ABq, J=8.4 Hz, 2H),7.91 (ABq, J=8.4 Hz, 2H), 7.57-7.49 (multi, 4H), 3.89 and 3.85 (sx2,3H), 2.46 (s, 3H), 2.45 (s, 3H), 1.34 (s, 9H).

LC-MS (ESI) 483 (M⁺).

Synthetic Example 56 Synthesis of4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)-N-methylbenzenesulfonamide

[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methanone(0.254 mmol, 85 mg), 4-(hydrazinocarbonyl)-N-methylbenzenesulfonamide(0.254 mmol, 58 mg) and p-tosylic acid monohydrate (30 mol %, 13 mg)were dissolved in isopropyl alcohol (8.5 mL) and stirred at 100° C. for19 hours. Then, the solvent was evaporated, and the residue was purifiedby silica gel thin layer chromatography (chloroform/methanol=10/1) togive the desired product as a yellow solid (30.3 mg, yield 22%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.69 and 11.32 (sx2, 1H), 9.84 and 8.64 (sx2, 1H), 8.64 (s, 1H),8.09-7.82 (multi, 4H), 7.69-7.44 (multi, 9H), 3.91-3.73 (multi, 3H),2.47 and 2.38 (multi, 3H), 1.34-1.33 (sx2, 9H).

LC-MS (ESI) 545 (M⁺).

Synthetic Example 57 Synthesis ofN′-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}-4-(1H-tetrazol-5-yl)benzhydrazide

1-[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.404 mmol, 110 mg) and 4-(1-H-tetrazol-5-yl)benzhydrazide (0.404 mmol,83 mg) synthesized in accordance with WO03/037328 were dissolved indimethylformamide (5 mL) and stirred at 100° C. for 26 hours. Theinsolubles were filtered off and washed with methanol, and the filtratewas concentrated and separated by silica gel thin layer chromatography(chloroform/MeOH=4/1) to give the desired product as a yellow solid (25mg, yield 13%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.22 (s, 1H), 9.76 (s, 1H), 8.13 (ABq, J=8.3 Hz, 2H), 7.99 (ABq,J=8.3 Hz, 2H), 7.57-7.50 (multi, 4H), 3.91 and 3.85 (sx2, 3H), 2.46 and2.42 (sx2, 3H), 1.34 (s, 9H).

LC-MS (ESI) 458 (M⁺).

Synthetic Example 58 Synthesis of4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoicacid 1) Synthesis of methyl4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate

1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(1.149 mmol, 312.9 mg) synthesized in Synthetic Example 3, methyl2-nitro-4-hydrazinocarbonylbenzoate (1.149 mmol, 274.8 mg) synthesizedin Reference Synthetic Example 40 and p-tosylic acid monohydride (30 mol%, 59.4 mg) were dissolved in isopropyl alcohol (30 mL) and stirredunder heating with reflux for 6 hours, and the reactor was cooled to 0°C. The reaction solution was filtered and dried by means of a vacuumpump to give the desired product as a yellow solid (470 mg, yield 83%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.54 (s, 1H), 9.57 (s, 1H), 8.57 (s, 1H), 8.33 (d, J=8.0 Hz, 1H),8.04 (d, J=8.0 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz,2H), 3.90 (s, 3H), 3.85 (s, 3H), 2.46 (s, 3H), 1.33 (s, 9H)

LC-MS (ESI) 493 (M⁺)

2) Synthesis of4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoicacid

To methyl4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate(0.945 mmol, 466.2 mg), methanol (33 mL) was added, and 1 M aqueoussodium hydroxide (4.7 mmol, 4.7 mL) was added. After about 26 hours ofstirring at room temperature and 3 hours of stirring at 40° C., 1 Mhydrochloric acid (4.7 mmol, 4.7 mL) and water were added. Theprecipitated solid was recovered by filtration, washed with water anddried by means of a vacuum pump. The resulting yellow solid (359.5 mg)was dissolved in THF (50 mL) and stirred at room temperature for 2 days.The insolubles were filtered off, and the filtrate was concentrated anddried by means of a vacuum pump. After addition of chloroform, theprecipitated solid was recovered by filtration and dried by means of avacuum pump to give the desired product as a pale yellow solid (260.7mg, yield 58%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.50 (s, 1H), 9.58 (s, 1H), 8.47 (s, 1H), 8.27 (d, J=8.1 Hz, 1H),7.99 (d, J=8.1 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz,2H), 3.85 (s, 3H), 2.46 (s, 3H), 1.33 (s, 9H)

LC-MS (ESI) 479 (M⁺)

Synthetic Example 59 Synthesis of4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoicacid 1) Synthesis of methyl4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoate

1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.568 mmol, 154.8 mg) synthesized in Synthetic Example 3, methyl2-chloro-4-hydrazinocarbonylbenzoate (0.568 mmol, 130.0 mg) synthesizedin Reference Synthetic Example 41 and p-tosylic acid monohydride (30 mol%, 29.4 mg) were dissolved in isopropyl alcohol (15 mL) and stirredunder heating with reflux for 8 hours, and the reactor was cooled to 0°C. The reaction solution was filtered and dried by means of a vacuumpump to give the desired product as a white solid (233.7 mg, yield 85%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.42 (s, 1H), 9.61 (s, 1H), 8.10 (s, 1H), 7.95 (s, 2H), 7.55 (ABq,J=8.6 Hz, 2H), 7.50 (ABq, J=8.6 Hz, 2H), 3.91 (s, 3H), 3.85 (s, 3H),2.45 (s, 3H), 1.33 (s, 9H)

LC-MS (ESI) 482 (M⁺)

2) Synthesis of4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoicacid

To methyl4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoate(0.465 mmol, 224.8 mg), methanol (20 mL) was added, and 1 M aqueoussodium hydroxide (2.3 mmol, 2.3 mL) was added. After 5 hours of stirringat 50° C., 14 hours of stirring at room temperature and 4 hours ofstirring at 50° C., 1 M hydrochloric acid (2.3 mmol, 2.3 mL) and waterwere added. The precipitated solid was recovered by filtration, washedwith water and dried by means of a vacuum pump to give the crude desiredproduct as a yellow solid (193.3 mg). Further, 169 mg of the crudedesired product was is dissolved in THF (35 mL) and stirred at roomtemperature for 2 days. The insolubles were filtered off, and thefiltrate was concentrated and dried by means of a vacuum pump. Afteraddition of chloroform, the precipitated solid was recovered byfiltration and dried by means of a vacuum pump to give the desiredproduct as a pale yellow solid (142.3 mg, yield 75%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.40 (s, 1H), 9.63 (s, 1H), 8.06 (s, 1H), 7.93 (d, J=8.1 Hz, 1H),7.89 (d, J=8.1 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz,2H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H)

LC-MS (ESI) 468 (M⁺)

Synthetic Example 60 Synthesis of2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid 1) Synthesis of methyl2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate

1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.554 mmol, 150.9 mg) synthesized in Synthetic Example 3, methyl2-bromo-4-hydrazinocarbonylbenzoate (0.554 mmol, 150.8 mg) synthesizedin Reference Synthetic Example 42 and p-tosylic acid monohydride (30 mol%, 28.6 mg) were dissolved in isopropyl alcohol (15 mL) and stirredunder heating with reflux for 8 hours, and the reactor was cooled to 0°C. The reaction solution was filtered and dried by means of a vacuumpump to give the desired product as a white solid (252.3 mg, yield 86%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.42 (s, 1H), 9.61 (s, 1H), 8.25 (d, J=2.7 Hz, 1H), 8.00 (dd, J=2.7,8.2 Hz, 1H), 7.89 (d, J=8.2 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50(ABq, J=8.4 Hz, 2H), 3.90 (s, 3H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s,9H)

LC-MS (ESI) 526 and 528 (M⁺)

2) Synthesis of2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

To methyl2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate(0.455 mmol, 239.8 mg), methanol (20 mL) was added, and 1 M aqueoussodium hydroxide (2.3 mmol, 2.3 mL) was added. After 5 hours of stirringat 50° C., 14 hours of stirring at room temperature and 4 hours ofstirring at 50° C., 1 M hydrochloric acid (2.3 mmol, 2.3 mL) and waterwere added. The precipitated solid was recovered by filtration, washedwith water and dried by means of a vacuum pump to give the crude desiredproduct as a yellow solid (203.8 mg). Further, 178 mg of the crudedesired product was dissolved in THF (35 mL) and stirred at roomtemperature for 2 days. The insolubles were filtered off, and thefiltrate was concentrated and dried by means of a vacuum pump. Afteraddition of chloroform, the precipitated solid was recovered byfiltration and dried by means of a vacuum pump to give the desiredproduct as a pale yellow solid (150.9 mg, yield 74%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.39 (s, 1H), 9.63 (s, 1H), 8.21 (s, 1H), 7.96 (d, J=8.0 Hz, 1H),7.83 (d, J=8.0 Hz, 1H), 7.55 (ABq, J=8.7 Hz, 2H), 7.50 (ABq, J=8.7 Hz,2H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H)

LC-MS (ESI) 512 and 514 (M⁺)

Synthetic Example 61 Synthesis of4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoicacid 1) Synthesis of methyl4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoate

1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.578 mmol, 157.5 mg) synthesized in Synthetic Example 3, methyl4-hydrazinocarbonyl-2-hydroxybenzoate (0.578 mmol, 121.6 mg) synthesizedin Reference Synthetic Example 43 and p-tosylic acid monohydride (30 mol%, 30 mg) were dissolved in isopropyl alcohol (15 mL) and stirred underheating with reflux for 8 hours, and the reactor was cooled to 0° C. Thereaction solution was filtered and dried by means of a vacuum pump togive the desired product as a white solid (216.6 mg, yield 81%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.33 (s, 1H), 10.61 (s, 1H), 9.65 (s, 1H), 7.89 (d, J=8.1 Hz, 1H),7.56-7.43 (multi, 6H), 3.92 (s, 3H), 3.85 (s, 3H), 2.45 and 2.44 (sx2,3H), 1.33 (s, 9H)

LC-MS (ESI) 464 (M⁺)

2) Synthesis of4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoicacid

To methyl4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoate(0.438 mmol, 203.3 mg), methanol (20 mL) was added, and 1 M aqueoussodium hydroxide (2.2 mmol, 2.2 mL) was added. After 5 hours of stirringat 50° C., 14 hours of stirring at room temperature and 4 hours ofstirring at 50° C., 1 M hydrochloric acid (2.2 mmol, 2.2 mL) and waterwere added. The precipitated solid was recovered by filtration, washedwith water and dried by means of a vacuum pump to give the crude desiredproduct as a yellow solid (175.0 mg). It was further dissolved in THF(35 mL) and stirred at room temperature for 2 days. The insolubles werefiltered off, and the filtrate was concentrated and dried by means of avacuum pump. After addition of chloroform, the precipitated solid wasrecovered by filtration and dried by means of a vacuum pump to give thedesired product as a pale yellow solid (151.6 mg, yield 77%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.30 (s, 1H), 10.61 (s, 1H), 9.66 (s, 1H), 7.90 (d, J=8.1 Hz, 1H),7.56-7.38 (multi, 6H), 3.85 (s, 3H), 2.44 (s, 3H), 1.33 (s, 9H)

LC-MS (ESI) 450 (M⁺)

Synthetic Example 62 Synthesis of methyl4-[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

From 2-(3-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene(100 mg, 0.35 mmol) synthesized in Reference Synthetic Example 49, thedesired product was obtained in the same manner as in Synthetic Example36 as a light brown solid (143 mg, yield 91%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.91 (s, 3H), 7.57-7.66 (m, 2H), 7.97-8.20 (m, 7H).

LC/MS (ES⁺) 463.

Synthetic Example 63 Synthesis of4-[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

From methyl4-[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate(120 mg, 0.26 mmol) synthesized in Synthetic Example 62, the desiredproduct was obtained in the same manner as in Synthetic Example 42 as apale yellow solid (50 mg, yield 43%).

¹H-NMR (ppm in DMSO-d₆)

δ 7.58-7.68 (m, 2H), 7.97-8.60 (m, 7H).

LC/MS (ES⁻) 447.

Synthetic Example 64 Synthesis of4-{[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}benzoicacid

From 2-(3-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (50mg, 0.17 mmol) synthesized in Reference Synthetic Example 49, thedesired product was obtained in the same manner as in Synthetic Example51 as a light brown solid (38 mg, 47%).

¹H-NMR (ppm in DMSO-d₆)

δ 2.41 (s, 3H), 7.57-8.44 (m, 9H).

LC/MS (ES⁺) 480.

Synthetic Example 65 Synthesis of methyl2-acetamino-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

To a suspension of2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (54.8 mg, 0.2mmol) and methyl 2-acetamino-4-hydrazinocarbonylbenzoate (50.2 mg, 0.2mmol) in isopropyl alcohol (2 mL), tosylic acid monohydrate (11.4 mg,0.06 mmol) was added, and the mixture was heated with reflux for 12hours. The precipitated solid was filtered to obtain 84 mg of thedesired product as a pale yellow solid (yield 83%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.29 (s, 9H), 2.13 (s, 3H), 2.49 (s, 3H), 3.86 (s, 3H), 7.42 (d, 2H,J=8.4 Hz), 7.68-7.71 (m, 3H), 7.96-7.98 (m, 2H), 8.53 (s, 1H), 10.54(brs, 1H), 11.48 (brs, 1H), 12.21 (brs, 1H).

LC/MS (ESI) 507 (M⁺).

Synthetic Example 66 Synthesis of2-acetamino-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

To a suspension of methyl2-acetamino-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}-hydrazino)carbonyl]benzoate(50.8 mg, 0.1 mmol) in isopropyl alcohol (1.0 mL), 0.2 M sodiumhydroxide aqueous solution (1.1 mL, 0.22 mmol) was added, and themixture was stirred at room temperature for 6 hours. After completion ofthe stirring, 1 M hydrochloric acid (220 μL) was added, and theprecipitated solid was filtered and then washed with methanol to obtain17.5 mg of the desired product as a pale yellow solid (yield 35%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.29 (s, 9H), 2.16 (s, 3H), 2.49 (s, 3H), 7.42 (d, 2H, J=8.4 Hz), 7.64(d, 1H, J=8.1 Hz), 7.70 (d, 2H, J=8.4 Hz), 7.98 (s, 1H), 8.07 (d, 1H,J=8.1 Hz), 8.87 (s, 1H), 11.05 (brs, 1H), 11.47 (brs, 1H), 12.22 (brs,1H).

LC/MS (ESI) 493 (M⁺).

Synthetic Example 67 Synthesis of methyl5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate

From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (57.4mg, 0.2 mmol), methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (40.0mg, 0.2 mmol) and tosylic acid monohydrate (11.4 mg, 0.06 mmol), 81.2 mgof the desired product was obtained in the same manner as in SyntheticExample 65 as a pale yellow solid (yield 87%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.88 (s, 3H), 7.64-7.71 (m, 2H), 7.91 (d, 1H, J=3.6 Hz), 8.05-8.13 (m,3H), 11.57 (brs, 1H).

LC/MS (ESI) 468, 470 (M⁺).

Synthetic Example 68 Synthesis of5-[(2-{1-[(5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylicacid

From methyl5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate(56.3 mg, 0.12 mmol) and 0.2 M sodium hydroxide aqueous solution (1.89mL, 0.38 mmol), 7.5 mg of the desired product was obtained in the samemanner as in Synthetic Example 66 as a pale yellow solid (yield 14%).

¹H-NMR (ppm in DMSO-d₆)

δ=7.64-7.72 (m, 2H), 7.91 (d, 1H, J=3.6 Hz), 8.06-8.14 (m, 3H), 11.54(brs, 1H).

LC/MS (ESI) 454, 456 (M⁺).

Synthetic Example 69 Synthesis of methyl5-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate

From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene(57.3 mg, 0.2 mmol), methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate(40.0 mg, 0.2 mmol) and tosylic acid monohydrate (11.4 mg, 0.06 mmol),68.0 mg of the desired product was obtained in the same manner as inSynthetic Example 65 as a pale yellow solid (yield 73%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.86 (s, 3H), 7.75 (d, 2H, J=8.4 Hz), 7.90 (d, 1H, J=4.2 Hz), 7.98 (d,2H, J=8.4 Hz), 8.08 (d, 1H, J=4.2 Hz), 8.15 (s, 1H), 11.56 (brs, 1H).

LC/MS (ESI) 468 (M⁺).

Synthetic Example 70 Synthesis of5-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylicacid

To a suspension of methyl5-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate(56.2 mg, 0.12 mmol) in t-butanol (1.2 mL), 0.2 M sodium hydroxideaqueous solution (1.26 mL, 0.25 mmol) was added, and the mixture wasstirred at room temperature for 4 hours. After completion of thestirring, 1 M hydrochloric acid (252 μL) was added, and the precipitatedsolid was filtered and washed with methanol to obtain 14.9 mg of thedesired product as an orange solid (yield 27%).

¹H-NMR (ppm in DMSO-d₆)

δ 7.76 (d, 2H, J=8.4 Hz), 7.81 (d, 1H, J=3.9 Hz), 8.00 (d, 2H, J=8.4Hz), 8.06 (d, 1H, J=3.9 Hz), 8.16 (s, 1H), 11.53 (brs, 1H).

LC/MS (ESI) 454 (Mt).

Synthetic Example 71 Synthesis of methyl2-nitro-4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene(57.3 mg, 0.2 mmol), methyl 4-hydrazinocarbonyl-2-nitrobenzoate (47.8mg, 0.2 mmol) and tosylic acid monohydrate (11.4 mg, 0.06 mmol), 81.7 mgof the desired product was obtained in the same manner as in SyntheticExample 65 as a pale yellow solid (yield 81%).

¹H-NMR (ppm in DMSO-d₆)

δ=3.89 (s, 3H), 7.75 (d, 2H, J=8.4 Hz), 8.00 (d, 2H, J=8.4 Hz), 8.04 (d,1H, J=7.8 Hz), 8.17 (s, 1H), 8.35 (d, 1H, J=7.8 Hz), 8.58 (s, 1H), 11.69(brs, 1H).

LC/MS (ESI) 507 (M⁺).

Synthetic Example 72 Synthesis of2-nitro-4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

From methyl2-nitro-4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate(60.9 mg (0.12 mmol) and 0.2 M sodium hydroxide aqueous solution (1.26mL, 0.25 mmol), 38.2 mg of the desired product was obtained in the samemanner as in Synthetic Example 70 as a pale yellow solid (yield 65%).

¹H-NMR (ppm in DMSO-d₆)

δ 7.76 (d, 2H, J=8.1 Hz), 8.00-8.05 (m, 3H), 8.18 (s, 1H), 8.31 (d, 1H,J=8.1 Hz), 8.52 (s, 1H), 11.68 (brs, 1H).

LC/MS (ESI) 493 (M⁺).

Synthetic Example 73 Synthesis of methyl2-fluoro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

From 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (59.0 mg,0.215 mmol), methyl 2-fluoro-4-hydrazinocarbonylbenzoate (45.6 mg, 0.215mmol) and tosylic acid monohydrate (12.3 mg, 0.0645 mmol), 94.9 mg ofthe desired product was obtained in the same manner as in SyntheticExample 65 as a pale yellow solid (yield 94%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.29 (s, 9H), 3.91 (s, 3H), 7.43 (d, 2H, J=8.4 Hz), 7.71 (d, 2H, J=8.4Hz), 7.85-7.94 (m, 2H), 8.01-8.08 (m, 2H), 11.50 (brs, 1H), 12.17 (brs,1H).

LC/MS (ESI) 468 (M⁺).

Synthetic Example 74 Synthesis of2-fluoro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

From methyl2-fluoro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate(56.2 mg, 0.12 mmol) and 0.2 M sodium hydroxide aqueous solution (1.26mL, 0.25 mmol), 46.3 mg of the desired product was obtained in the samemanner as in Synthetic Example 70 as a pale yellow solid (yield 85%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.29 (s, 9H), 7.43 (d, 2H, J=8.4 Hz), 7.71 (d, 2H, J=8.4 Hz),7.83-7.94 (m, 2H), 7.99-8.04 (m, 2H), 11.48 (brs, 1H), 12.18 (brs, 1H).

LC/MS (ESI) 452 (M⁺).

Synthetic Example 75 Synthesis of methyl4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl](isopropyl)methylene}hydrazino)-carbonyl]benzoate

A suspension of2-(4-t-butylphenyl)-3-hydroxy-4-isopropylcarbonylthiophene (100 mg, 0.33mmol), 4-hydrazinocarbonylmethylbenzoate (70 mg, 0.36 mmol) andp-tosylic acid monohydrate in isopropyl alcohol, was dehydrated withreflux for 2 days. After completion of the reaction, the reactionsolution was cooled to room temperature and filtered to obtain thedesired product as a yellow solid (92 mg, yield 58%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 1.38 (s, 3H), 1.41 (s, 3H), 3.91 (s, 3H), 7.43 (d, J=8.3Hz, 2H), 7.71 (d, J=8.3 Hz, 2H), 8.02-8.1.3 (m, 5H).

LC/MS (ES⁺) 479.

Synthetic Example 76 Synthesis of4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl](isopropyl)methylene}hydrazino)carbonyl]benzoicacid

Using methyl4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl](isopropyl)methylene}-hydrazino)carbonyl]benzoate(80 mg, 0.17 mmol) as the starting material, the desired product wasobtained in the same manner as in Synthetic Example 70 as a pale yellowsolid (19 mg, yield 24%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 1.39-1.41 (m, 6H), 7.42-7.44 (m, 2H), 7.70-7.73 (m, 2H),8.00-8.10 (m, 6H).

LC/MS (ES⁺) 465.

Synthetic Example 77 Synthesis of methyl2-nitro-4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

Using 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (100mg, 0.35 mmol) and methyl 2-nitro-4-hydrazinocarbonylbenzoate (93 mg,0.39 mmol) as the starting materials, the desired product was obtainedin the same manner as in Synthetic Example 65 as a yellow solid (147 mg,yield 83%).

¹H-NMR (ppm in DMSO-d₆)

δ 3.91 (s, 3H), 7.55-7.75 (m, 2H), 8.05-8.20 (m, 3H), 8.30-8.40 (m, 1H),8.50-8.65 (m, 1H).

LC/MS (ES⁻) 507.

Synthetic Example 78 Synthesis of2-nitro-4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

Using methyl2-nitro-4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate(137 mg, 0.27 mmol) as the starting material, the desired product wasobtained in the same manner as in Synthetic Example 66 as a yellow solid(68 mg, yield 51%).

LC/MS (ES⁺) 494, 495.

Synthetic Example 79 Synthesis of methyl2-bromo-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

Using 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (55 mg,0.20 mmol) and methyl 2-bromo-4-hydrazinocarbonylbenzoate (60 mg, 0.22mmol) as the starting materials, the desired product was obtained in thesame manner as in Synthetic Example 65 as a yellow solid (92 mg, yield87%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 3.91 (s, 3H), 7.43 (d, J=8.5 Hz, 2H), 7.71 (d, J=8.5 Hz,2H), 7.91 (d, J=8.0 Hz, 1H), 8.01-8.03 (m, 2H), 8.27 (s, 1H).

LC/MS (ES⁻) 528.

Synthetic Example 80 Synthesis of2-bromo-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

Using methyl2-bromo-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate(82 mg, 0.15 mmol) as the starting material, the desired product wasobtained in the same manner as in Synthetic Example 66 as a yellow solid(67 mg, yield 870).

¹H-NMR (ppm in DMSO-d₆)

δ 1.31 (s, 9H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.4 Hz, 2H),7.87-7.89 (m, 1H), 7.97-8.01 (m, 2H), 8.24 (s, 1H).

LC/MS (ES⁺) 517, 519.

Synthetic Example 81 Synthesis of methyl2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

Using 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (55 mg,0.20 mmol) and methyl 2-chloro-4-hydrazinocarbonylbenzoate (50 mg, 0.22mmol) as the starting materials, the desired product was obtained in thesame manner as in Synthetic Example 65 as a pale yellow solid (86 mg,yield 89%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.30 (s, 9H), 3.91 (s, 3H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.5 Hz,2H), 7.97-8.01 (m, 3H), 8.12 (s, 1H).

LC/MS (ES⁻) 483, 485.

Synthetic Example 82 Synthesis of2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid

Using methyl2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonyl]benzoate(76 mg, 0.16 mmol) as the starting material, the desired product wasobtained in the same manner as in Synthetic Example 66 as a pale yellowsolid (60 mg, yield 80%).

LC/MS (ES⁺) 471, 473.

Synthetic Example 83 Synthesis of methyl4-[(2-{1-[2-bromo-5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate

To a suspension of2-bromo-5-(4-t-butylphenyl)-4-hydroxy-3-methylcarbonylthiophene (1.00 g,2.83 mmol) synthesized in Reference Synthetic Example 55 and4-hydrazinocarbonylmethylbenzoate (550 mg, 2.83 mmol) in isopropylalcohol (28.3 mL), tosylic acid monohydrate (146 mg, 0.85 mmol) wasadded, and the mixture was heated with reflux for about 1 hour. Thereaction solution was concentrated, and then purified with a silica gelcolumn chromatography (chloroform, and then chloroform/ethylacetate=95/5) to obtain the desired product as a yellow solid (935 mg,yield 62%).

¹H-NMR (ppm in DMSO-d₆)

δ 1.29 (s, 9H), 2.61 (s, 3H), 3.91 (s, 3H), 7.44 (d, J=8.4 Hz, 2H), 7.65(d, J=8.4 Hz, 2H), 8.06-8.14 (m, 4H), 11.69 (s, 1H), 12.29 (s, 1H).

LC/MS (ES⁺) 529, 531.

Synthetic Example 84 Synthesis of methyl4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate

From1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(0.70 mmol, 200 mg) synthesized in Synthetic Example 1, methyl2-nitro-4-hydrazinocarbonylbenzoate (0.70 mmol, 167.8 mg) of ReferenceSynthetic Example 40 and tosylic acid monohydrate (36.2 mg, 0.21 mmol),311.1 mg of the desired product was obtained in the same manner as inSynthetic Example 58 as a yellow solid (yield 88%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.61 (s, 1H), 9.85 (s, 1H), 8.58 (d, J=1.4 Hz, 1H), 8.34 (dd, J=1.4,8.0 Hz, 1H), 8.04 (d, J=8.0 Hz, 1H), 7.86 (d, J=1.9 Hz, 2H), 7.80 (d,J=8.4 Hz, 1H), 7.61 (dd, J=1.9, 8.4 Hz, 1H), 3.90 (s, 6H), 2.46 (s, 3H).

LC-MS (ESI) 505 (M⁺)

Synthetic Example 85 Synthesis of4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoicacid

From methyl4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate(0.40 mmol, 200 mg) and 1 M sodium hydroxide aqueous solution (1.98 mL,1.98 mmol), 130.5 mg of the desired product was obtained in the samemanner as in Synthetic Example 58 as a yellow solid (yield 67%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.58 (s, 1H), 9.86 (s, 1H), 8.50 (s, 1H), 8.27-8.32 (m, 1H), 8.01 (d,J=8.0 Hz, 1H), 7.85-7.86 (m, 1H), 7.80 (d, J=8.5 Hz, 1H), 7.60-7.62 (m,1H), 3.90 (s, 3H), 2.46 (s, 3H).

LC-MS (ESI) 491 (M⁺)

Synthetic Example 86 Synthesis of methyl4-{[2-(1-[4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl]-ethylidene)hydrazino]carbonyl}-2-nitrobenzoate

From1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone(0.70 mmol, 200 mg) synthesized in Synthetic Example 11, methyl2-nitro-4-hydrazinocarbonylbenzoate (0.70 mmol, 168.3 mg) of ReferenceSynthetic Example 40 and tosylic acid monohydrate (36.4 mg, 0.21 mmol),214.7 mg of the desired product was obtained in the same manner as inSynthetic Example 58 as a yellow solid (yield 60%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.62 (s, 1H), 9.88 (s, 1H), 8.58 (d, J=1.5 Hz, 1H), 8.35 (dd, J=1.5,8.0 Hz, 1H), 8.05 (d, J=8.0 Hz, 1H), 7.90 (ABq, J=8.7 Hz, 2H), 7.84(ABq, J=8.7 Hz, 2H), 3.93 (s, 3H), 3.90 (s, 3H), 2.48 (s, 3H).

LC-MS (ESI) 505 (M⁺).

Synthetic Example 87 Synthesis of4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-nitrobenzoicacid

From methyl4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-nitrobenzoate(0.30 mmol, 150 mg) and 1 M sodium hydroxide aqueous solution (1.48 mL,1.48 mmol), 106.0 mg of the desired product was obtained in the samemanner as in Synthetic Example 58 as a pale yellow solid (yield 73%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.59 (s, 1H), 9.88 (s, 1H), 8.50 (s, 1H), 8.28-8.31 (m, 1H), 8.02 (d,J=8.0 Hz, 1H), 7.90 (ABq, J=8.7 Hz, 2H), 7.84 (ABq, J=8.7 Hz, 2H), 3.93(s, 3H), 2.47 (s, 3H).

LC-MS (ESI) 491 (M⁺).

Synthetic Example 88 Synthesis of methyl5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate

From1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(200 mg, 0.70 mmol) synthesized in Synthetic Example 1, methyl5-hydrazinocarbonyl-2-thiophenecarboxylate (0.70 mmol, 140.4 mg) ofReference Synthetic Example 39 and tosylic acid monohydrate (36.2 mg,0.21 mmol), 314.1 mg of the desired product was obtained in the samemanner as in Synthetic Example 58 as a yellow solid (yield 96%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.47 (s, 1H), 9.76 (s, 1H), 8.04-8.07 (m, 1H), 7.79-7.91 (m, 3H),7.56-7.61 (s, 1H), 3.87 (s, 6H), 2.46 (s, 3H).

LC-MS (ESI) 466 (M⁺).

Synthetic Example 89 Synthesis of5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylicacid

From methyl5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate(200 mg, 0.43 mmol) and 1 M sodium hydroxide aqueous solution (2.13 mL,2.13 mmol), 153.3 mg of the desired product was obtained in the samemanner as in Synthetic Example 58 as a yellow solid (yield 84%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.43 (s, 1H), 9.78 (s, 1H), 8.03-8.32 (m, 1H), 7.79-7.85 (m, 3H),7.58-7.61 (m, 1H), 3.89 (s, 3H), 2.46 (s, 3H).

LC-MS (ESI) 452 (M⁺).

Synthetic Example 90 Synthesis of methyl5-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-thiophenecarboxylate

From1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone(200 mg, 0.70 mmol) synthesized in Synthetic Example 11, methyl5-hydrazinocarbonyl-2-thiophenecarboxylate (0.70 mmol, 140.9 mg) ofReference Synthetic Example 39 and tosylic acid monohydrate (36.4 mg,0.21 mmol), 188.2 mg of the desired product was obtained in the samemanner as in Synthetic Example 58 as a pale yellow solid (yield 57%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.48 (s, 1H), 9.78 (s, 1H), 8.06-8.08 (m, 1H), 7.82-7.91 (m, 5H),3.92 (s, 3H), 3.87 (s, 3H), 2.47 (s, 3H).

LC-MS (ESI) 466 (M⁺).

Synthetic Example 91 Synthesis of5-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-thiophenecarboxylicacid

From methyl5-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-thiophenecarboxylate(150 mg, 0.32 mmol) and 1 M sodium hydroxide aqueous solution (1.60 mL,1.60 mmol), 89.0 mg of the desired product was obtained in the samemanner as in Synthetic Example 58 as a pale yellow solid (yield 61%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.44 (s, 1H), 9.80 (s, 1H), 8.03-8.04 (m, 1H), 7.80-7.91 (m, 5H),3.92 (s, 3H), 2.47 (s, 3H).

LC-MS (ESI) 452 (M⁺).

Synthetic Example 92 Synthesis of methyl4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate

Dimethylformamide (1.3 mL) and conc. hydrochloric acid (1 drop) wereadded to 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (71 mg,0.26 mmol) synthesized in Reference Synthetic Example 33 and methyl4-hydrazinocarbonothioylamino-2-nitrobenzoate (70 mg, 0.26 mmol)synthesized in Reference Synthetic Example 56, and the mixture wasstirred at room temperature for 2 days. The precipitated solid wasfiltered to obtain 110 mg of the desired product as a pale yellow solid(yield 81%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.29 (bs, 1H), 10.67 (bs, 1H), 8.57 (bs, 1H), 7.87-8.03 (m, 3H), 7.67(d, J=8.4 Hz, 2H), 7.41 (d, J=8.4 Hz, 2H), 3.83 (s, 3H), 2.40 (s, 3H),1.28 (s, 9H).

LC/MS (ESI) 526.

Synthetic Example 93 Synthesis of4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoicacid

Methyl4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate(95 mg, 0.18 mmol) synthesized in Synthetic Example 92 was dissolved inisopropyl alcohol (1.8 mL), and 0.2 M sodium hydroxide aqueous solution(2.0 mL, 0.40 mmol) was added thereto, followed by stirring overnight atroom temperature. After completion of the stirring, 1 M hydrochloricacid (0.40 mL, 0.40 mmol) and water were added thereto, and theprecipitated solid was filtered to obtain 57 mg of the desired productas a pale yellow solid (yield 61%).

¹H-NMR (ppm in DMSO-d₆)

δ 11.29 (bs, 1H), 10.64 (bs, 1H), 8.50 (bs, 1H), 7.87-8.00 (m, 3H), 7.69(d, J=8.4 Hz, 2H), 7.43 (d, J=8.4 Hz, 2H), 2.41 (s, 3H), 1.29 (s, 9H).

LC/MS (ESI) 512.

Synthetic Example 94 Synthesis of methyl4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate

From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (60 mg,0.21 mmol) synthesized in Reference Synthetic Example 34, the desiredproduct was obtained in the same manner as in Synthetic Example 92 as ayellow solid (88 mg, yield 78%).

¹H-NMR (ppm in DMSO)

δ 11.35 (bs, 1H), 10.70 (bs, 1H), 8.57 (bs, 1H), 8.14 (s, 1H), 8.01-8.04(m, 2H), 7.89-7.91 (m, 1H), 7.65-7.74 (m, 2H), 3.84 (s, 3H), 2.42 (s,3H).

LC/MS (ESI) 538.

Synthetic Example 95 Synthesis of4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoicacid

From methyl4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate(70 mg, 0.13 mmol) synthesized in Synthetic Example 94, the desiredproduct was obtained in the same manner as in Synthetic Example 93 as apale yellow solid (43 mg, yield 63%).

¹H-NMR (ppm in DMSO)

δ 11.32 (bs, 1H), 10.66 (bs, 1H), 8.48 (bs, 1H), 8.13 (s, 1H), 7.87-8.02(m, 3H), 7.64-7.74 (m, 2H), 2.41 (s, 3H).

LC/MS (ESI) 524.

Synthetic Example 96 Synthesis of methyl4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate

From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (60mg, 0.21 mmol) synthesized in Reference Synthetic Example 35, thedesired product was obtained in the same manner as in Synthetic Example92 as a yellow solid (103 mg, yield 91%).

¹H-NMR (ppm in DMSO)

δ 11.36 (bs, 1H), 10.72 (bs, 1H), 8.58 (bs, 1H), 8.17 (s, 1H), 7.89-8.04(m, 4H), 7.76 (d, J=8.3 Hz, 2H), 3.84 (s, 3H), 2.43 (s, 3H).

LC/MS (ESI) 538.

Synthetic Example 97 Synthesis of4-{[(2-{(1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]-amino}-2-nitrobenzoicacid

From methyl4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate(90 mg, 0.17 mmol) synthesized in Synthetic Example 96, the desiredproduct was obtained in the same manner as in Synthetic Example 93 as apale yellow solid (69 mg, yield 79%).

¹H-NMR (ppm in DMSO)

δ 11.34 (bs, 1H), 10.65-10.67 (m, 1H), 8.49 (bs, 1H), 8.16 (s, 1H),7.88-8.01 (m, 4H), 7.76 (d, J=8.5 Hz, 2H), 2.43 (s, 3H).

LC/MS (ESI) 524.

Synthetic Example 98 Synthesis of methyl5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylate

Dimethylformamide (1.3 ml) and conc. hydrochloric acid (1 drop) wereadded to 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (70 mg,0.26 mmol) synthesized in Reference Synthetic Example 33 and methyl5-hydrazinocarbonothioylamino-2-thiophenecarboxylate (59 mg, 0.26 mmol)synthesized in Reference Synthetic Example 57, and the mixture wasstirred overnight at room temperature. Water was added, and theprecipitated solid was filtered. The obtained solid was extracted withchloroform, dried over anhydrous sodium sulfate. The organic layer wasconcentrated, and purified with a silica gel column chromatography(chloroform/methanol=95/5) to obtain the desired product as a paleyellow solid (112 mg, yield 90%).

¹H-NMR (ppm in DMSO)

δ 11.63 (bs, 1H), 11.18 (bs, 1H), 8.01 (bs, 1H), 7.72 (d, J=8.5 Hz, 2H),7.67 (d, J=4.4 Hz, 1H), 7.46 (d, J=8.5 Hz, 2H), 6.92 (d, J=4.4 Hz, 1H),3.82 (s, 3H), 2.41 (s, 3H), 1.32 (s, 9H).

LC/MS (ESI) 487.

Synthetic Example 99 Synthesis of5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylicacid

Methyl5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylate(85 mg, 0.18 mmol) synthesized in Synthetic Example 98 was dissolved inisopropyl alcohol (1.8 ml), and 0.2 M sodium hydroxide aqueous solution(1.95 ml, 0.39 mmol) was added thereto, following by stirring overnightat room temperature. Then 0.2 M sodium hydroxide aqueous solution (0.96ml, 0.19 mmol) was added thereto, following by stirring overnight at 45°C. After completion of the stirring, 1 M hydrochloric acid (0.58 ml,0.58 mmol) was added. The precipitated solid was filtered to obtain 2.7mg of the desired product as a pale yellow solid (yield 3%).

LC/MS (ESI) 473.

Synthetic Example 100 Synthesis of methyl4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoate

From 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (60 mg,0.22 mmol) synthesized in Reference Synthetic Example 33, the desiredproduct was obtained in the same manner as in Synthetic Example 92 as ayellow solid (118 mg, yield 100%).

¹H-NMR (ppm in DMSO)

δ 11.21 (bs, 1H), 10.50 (bs, 1H), 8.21 (bs, 1H), 7.97 (d, J=8.5 Hz, 1H),7.89 (d, J=8.5 Hz, 1H), 7.68-7.71 (m, 3H), 7.43 (d, J=8.3 Hz, 2H), 3.85(s, 3H), 2.40 (s, 3H), 1.29 (s, 9H).

LC/MS (ESI) 515.

Synthetic Example 101 Synthesis of4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoicacid

Methyl4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate(100 mg, 0.19 mmol) synthesized in Synthetic Example 100 was dissolvedin isopropyl alcohol (1.9 ml), and 0.2 M sodium hydroxide aqueoussolution (2.1 ml, 0.42 mmol) was added thereto, following by stirringovernight at room temperature, then at 45° C. for 1 day. Then 0.2 Msodium hydroxide aqueous solution (1.1 ml, 0.22 mmol) was added thereto,following by stirring at 45° C. for 5.5 hours. After completion of thestirring, 1 M hydrochloric acid (0.64 ml, 0.64 mmol) was added. Theprecipitated solid was filtered, and purified with a silica gel plate(chloroform/methanol=9/1) to obtain the desired product as a yellowsolid (24 mg, yield 25%).

¹H-NMR (ppm in DMSO)

δ 10.48 (bs, 1H), 8.18 (bs, 1H), 7.84-7.94 (m, 2H), 7.65-7.68 (m, 3H),7.40-7.43 (m, 2H), 2.41 (s, 3H), 1.29 (s, 9H).

LC/MS (ESI) 501.

Synthetic Example 102 Synthesis of methyl4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate

From 1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(63 mg, 0.23 mmol) synthesized in Synthetic Example 3, the desiredproduct was obtained in the same manner as in Synthetic Example 92 as ayellow solid (121 mg, yield 100%).

¹H-NMR (ppm in DMSO)

δ 10.53 (bs, 1H), 8.60-8.61 (m, 1H), 7.87-8.06 (m, 2H), 7.47-7.60 (m,4H), 3.84 (s, 3H), 3.82 (s, 3H), 2.41 (s, 3H), 1.33 (s, 9H).

LC/MS (ESI) 524.

Synthetic Example 103 Synthesis of4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoicacid

Methyl4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate(100 mg, 0.19 mmol) synthesized in Synthetic Example 102 was dissolvedin methanol (6.7 ml), and 1 M sodium hydroxide aqueous solution (0.96ml, 0.96 mmol) was added thereto, following by stirring overnight atroom temperature. After, completion of the stirring, the reactionsolution was washed with ethyl acetate, and to the aqueous layer, 1 Mhydrochloric acid was added. The precipitated solid was filtered toobtain 27 mg of the desired product as a pale yellow solid (yield 28%).

¹H-NMR (ppm in DMSO)

δ 11.10 (bs, 1H), 10.50 (bs, 1H), 8.49 (bs, 1H), 7.86-7.97 (m, 2H),7.47-7.59 (m, 4H), 3.82-3.83 (m, 3H), 2.41 (s, 3H), 1.33-1.34 (m, 9H).

LC/MS (ESI) 510.

Synthetic Example 104 Synthesis of methyl4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}-hydrazino)carbonothioyl]amino}-2-nitrobenzoate

Dimethylformamide (1 ml) and conc. hydrochloric acid (1 drop) were addedto 1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(60 mg, 0.21 mmol) synthesized in Synthetic Example 1 and methyl4-hydrazinocarbonothioylamino-2-nitrobenzoate (57 mg, 0.21 mmol)synthesized in Reference Synthetic Example 56, and the mixture wasstirred at room temperature for 21 hours. Water was added, and theprecipitated solid was filtered, purified with a silica gel columnchromatography (n-hexane/ethyl acetate=1/1 thenchloroform/methanol=95/5). The obtained solid was extracted with ethylacetate, washed with a saturated ammonium chloride aqueous solution,saturated sodium chloride aqueous solution. The organic layer wasconcentrated to obtain the desired product as a pale yellow solid (104mg, yield 92%).

¹H-NMR (ppm in DMSO)

δ 8.57 (bs, 1H), 8.03-8.05 (m, 1H), 7.78-7.90 (m, 3H), 7.56-7.59 (m,1H), 3.86 (s, 3H), 3.84 (s, 3H), 2.41 (s, 3H).

LC/MS (ESI) 536.

Synthetic Example 105 Synthesis of4-{[(2-{1-[(5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoicacid

Methyl4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate(100 mg, 0.19 mmol) synthesized in Synthetic Example 104 was dissolvedin methanol (3 ml), and 1 M sodium hydroxide aqueous solution (0.74 ml,0.74 mmol) was added thereto, following by stirring overnight at roomtemperature. After completion of the stirring, 1 M hydrochloric acid(0.74 ml, 0.74 mmol) and water were added thereto. The precipitatedsolid was recovered by filtration, washed with water, isopropyl alcohol,and chloroform. The obtained solid was stirred in chloroform, and thenfiltered to obtain 37 mg of the desired product as a yellow solid (yield48%).

¹H-NMR (ppm in DMSO)

δ 8.47 (bs, 1H), 7.77-7.93 (m, 4H), 7.56-7.59 (m, 1H), 3.86 (s, 3H),2.42 (s, 3H).

LC/MS (ESI) 522.

Synthetic Example 106 Synthesis of4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoicacid

From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone,synthesized in the same manner as in Synthetic Example 1, the desiredproduct was obtained in the same manner as in Synthetic Examples 102 and103 as a yellow solid (22.6 mg).

¹H-NMR (ppm in DMSO)

δ 8.48 (bs, 1H), 7.50-8.00 (m, 6H), 3.88 (s, 3H), 2.42 (s, 3H).

LC/MS (ESI) 488

Synthetic Example 107 Synthesis of4-[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoicacid

From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanonesynthesized in the same manner as in Synthetic Example 1, the desiredproduct was obtained in the same manner as in Synthetic Example 58 as apale yellow solid (19.1 mg).

¹H-NMR (ppm in DMSO)

δ 11.5 (1H, s), 9.73 (1H, s), 8.49 (1H, s), 8.28 (1H, d, J=8 Hz), 8.01(1H, d, J=8 Hz), 7.65-7.55 (4H, m), 3.87 (3H, s), 2.46 (3H, s).

LC/MS (ESI) 457

Synthetic Example 108 Synthesis of5-[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylicacid

From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanonesynthesized in the same manner as in Synthetic Example 1, the desiredproduct was obtained in the same manner as in Synthetic Examples 33 and34 as a yellow solid (20.2 mg).

¹H-NMR (ppm in DMSO)

δ11.4 (1H, s), 9.64 (1H, s), 8.02 (1H, d, J=3 Hz), 7.80 (1H, d, J=3 Hz),7.5-7.7 (4H, m), 3.86 (3H, s), 2.45 (3H, s).

LC/MS (ESI) 418

Synthetic Example 109 Synthesis of4-[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoicacid

From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanonesynthesized in the same manner as in Synthetic Example 1, the desiredproduct was obtained in the same manner as in Synthetic Example 3 as ayellow solid (47.4 mg).

¹H-NMR (ppm in DMSO)

δ 11.4 (1H, s), 9.83 (1H, s), 7.90-8.20 (4H, m), 7.50-7.70 (4H, m), 3.86(3H, s), 2.45 (3H, s).

LC/MS (ESI) 412

Synthetic Example 110 Synthesis of4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoicacid

From methyl4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate(70 mg, 0.13 mmol), the desired product was obtained in the same manneras in Synthetic Examples 104 and 105 as a yellow solid (42 mg, yield62%).

¹H-NMR (ppm in DMSO)

δ 8.48 (bs, 1H), 7.80-8.00 (m, 6H), 3.88 (s, 3H), 2.42 (s, 3H).

LC/MS (ESI) 522.

Synthetic Example 111 Synthesis of4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoicacid

From methyl4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate(82 mg, 0.16 mmol), the desired product was obtained in the same manneras in Synthetic Examples 104 and 105 as a brown solid (40 mg, yield50%).

¹H-NMR (ppm in DMSO)

δ 8.12-8.26 (m, 1H), 7.50-7.81 (m, 6H), 3.82 (s, 3H), 2.41 (s, 3H), 1.32(s, 9H).

LC/MS (ESI) 499.

Synthetic Example 112 Synthesis of4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoicacid

From methyl4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate(105 mg, 0.20 mmol), the desired product was obtained in the same manneras in Synthetic Examples 104 and 105 as a pale yellow solid (54 mg,yield 52%)

¹H-NMR (ppm in DMSO)

δ 8.09 (bs, 1H), 7.77-7.85 (m, 3H), 7.65-7.68 (m, 1H), 7.55-7.58 (m,1H), 3.84 (s, 3H), 2.39 (s, 3H).

LC/MS (ESI) 511.

Synthetic Example 113 Synthesis of4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoicacid

From methyl4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate(60 mg, 0.11 mmol), the desired product was obtained in the same manneras in Synthetic Examples 104 and 105 as a pale yellow solid (25 mg,yield 42%).

¹H-NMR (ppm in DMSO)

δ 8.11 (bs, 1H), 7.80-7.94 (m, 5H), 7.67-7.70 (m, 1H), 3.88 (s, 3H),2.41 (s, 3H).

LC/MS (ESI) 511.

Synthetic Example 114 Synthesis of5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylicacid 1) Synthesis of 5-hydrazinocabonothioylamino-2-thiophenecarboxylicacid

To methyl 5-hydrazinocabonothioylamino-2-thiophenecarboxylate (1.21mmol, 280 mg) obtained in Reference Synthetic Example 57, methanol (2.4ml) was added, and 0.2 M aqueous sodium hydroxide (3 eq, 18.2 ml) wasadded at room temperature. After stirring of 1.5 hours at 60° C., thereactor was cooled to room temperature, and 1 M hydrochloric acid (3 eq,3.63 ml) was added. The precipitated solid was recovered by filtration,washed with water and chloroform and dried by means of a vacuum pump.The desired product was obtained as a pale yellow solid (230 mg, yield87.6% (LC purity 90%)).

¹H-NMR (ppm in DMSO)

δ 9.56 (bs, 1H), 7.47 (d, J=4.1 Hz, 1H), 7.07 (bs, 1H), 6.91 (bs, 1H).

LC/MS (ESI) 217.

2) Synthesis of5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylicacid

From 1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(40.0 mg, 0.15 mmol) and5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (35.5 mg, 0.15mmol), the desired product was obtained in the same manner as inSynthetic Example 2 as a yellow solid (57.3 mg, yield 83%).

¹H-NMR (ppm in DMSO)

δ 7.47-7.56 (m, 5H), 6.90 (bs, 1H), 3.82 (s, 3H), 2.39 (s, 3H), 1.34 (s,9H).

LC/MS (ESI) 471.

Synthetic Example 115 Synthesis of5-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylicacid

From1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(40.0 mg, 0.14 mmol) and5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (33.9 mg, 0.14mmol), the desired product was obtained in the same manner as inSynthetic Example 114 as a pale yellow solid (62.2 mg, yield 92%).

¹H-NMR (ppm in DMSO)

δ 7.84 (d, J=1.7 Hz, 1H), 7.80 (d, J=8.3 Hz, 1H), 7.54-7.60 (m, 2H),6.90 (bs, 1H), 3.86 (s, 3H), 2.39 (s, 3H).

LC/MS (ESI) 483.

Synthetic Example 116 Synthesis of5-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylicacid

From1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(40.0 mg, 0.14 mmol) and5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (34.0 mg, 0.14mmol), the desired product was obtained in the same manner as inSynthetic Example 114 as a pale yellow solid (55.8 mg, yield 82%).

¹H-NMR (ppm in DMSO)

δ 7.81-7.91 (m, 4H), 7.55 (d, J=4.1 Hz, 1H), 6.90 (bs, 1H), 3.89 (s,3H), 2.40 (s, 3H).

LC/MS (ESI) 483.

Synthetic Example 117 Synthesis of5-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylicacid

From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(37.5 mg, 0.15 mmol) and5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (33 mg, 0.14mmol), the desired product was obtained in the same manner as inSynthetic Example 114 as a pale yellow solid (62.0 mg, yield 83%).

¹H-NMR (ppm in DMSO)

δ 7.45-7.56 (m, 5H), 6.94 (bs, 1H), 3.87 (s, 3H), 2.43 (s, 3H).

LC/MS (ESI) 449.

Synthetic Example 118 Synthesis of4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoicacid 1) Synthesis of 4-hydrazinocabonothioylamino-2-chlorobenzoic acid

To methyl 4-hydrazinocabonothioylamino-2-chlorobenzoate (1.16 mmol, 300mg) obtained in Reference Synthetic Example 58, methanol (2.3 ml) wasadded, and 0.2 M aqueous sodium hydroxide (2.1 eq, 12.1 ml) was added atroom temperature. After stirring of 1.5 hours at 60° C., the reactor wascooled to room temperature, and 1 M hydrochloric acid (2.1 eq, 2.43 ml)was added. The precipitated solid was recovered by filtration, washedwith water and dried by means of a vacuum pump.4-Hydrazinocabonothioylamino-2-chlorobenzoic acid was obtained as acolorless solid (262.8 mg, yield 92.6%).

¹H-NMR (ppm in DMSO)

δ 9.48 (bs, 1H), 8.22 (bs, 1H), 7.75-7.77 (m, 3H).

LC/MS (ESI) 245.

2) Synthesis of4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoicacid

From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (50 mg,0.17 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoic acid (42.8mg, 0.17 mmol), the desired product was obtained in the same manner asin Synthetic Example 50 as a pale yellow solid (61.1 mg, yield 68%).

¹H-NMR (ppm in DMSO)

δ 11.20 (bs, 1H), 10.46 (bs, 1H), 8.14 (bs, 1H), 8.11 (s, 1H), 8.02 (d,J=1.9 Hz, 1H), 7.87 (d, J=8.5 Hz, 1H), 7.64-7.74 (m, 3H), 2.40 (s, 3H).

LC/MS (ESI) 513.

Synthetic Example 119 Synthesis of4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoicacid

From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene(50.0 mg, 0.17 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoicacid (42.9 mg, 0.17 mmol), the desired product was obtained in the samemanner as in Synthetic Example 118 as a pale yellow solid (58.3 mg,yield 65%).

¹H-NMR (ppm in DMSO)

δ 11.22 (bs, 1H), 10.47 (bs, 1H), 8.13-8.15 (m, 2H), 8.00 (d, J=8.3 Hz,2H), 7.87 (d, J=8.5 Hz, 1H), 7.76 (d, J=8.3 Hz, 2H), 7.65-7.68 (m, 1H),2.41 (s, 3H).

LC/MS (ESI) 513.

Synthetic Example 120 Synthesis of4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoicacid

From 1-[5-(4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone(37.5 mg, 0.15 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoicacid (36.9 mg, 0.15 mmol), the desired product was obtained in the samemanner as in Synthetic Example 114 as a yellow solid (59.5 mg, yield92%).

¹H-NMR (ppm in DMSO)

δ 7.40-8.40 (m, 7H), 3.78-3.84 (m, 3H), 2.40 (s, 3H).

LC/MS (ESI) 477.

Synthetic Example 121 Synthesis of5-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylicacid

From 2-(4-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25.3 mg,0.10 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid(21.8 mg, 0.10 mmol), the desired product was obtained in the samemanner as in Synthetic Example 50 as a pale yellow solid (37.1 mg, yield82%).

¹H-NMR (ppm in DMSO)

δ 11.54 (bs, 1H), 11.13 (bs, 1H), 8.04 (s, 1H), 7.80-7.82 (m, 2H), 7.87(d, J=4.1 Hz, 1H), 7.46-7.50 (m, 2H), 6.86-6.87 (m, 1H), 2.39 (s, 3H).

LC/MS (ESI) 451.

Synthetic Example 122 Synthesis of4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoicacid

From 2-(4-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25.2 mg,0.1 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoic acid (24.5mg, 0.1 mmol), the desired product was obtained in the same manner as inSynthetic Example 50 as a pale yellow solid (41.9 mg, yield 88%).

¹H-NMR (ppm in DMSO)

δ 11.21 (bs, 1H), 10.47 (bs, 1H), 8.15 (s, 1H), 8.05 (s, 1H), 7.87 (d,J=8.3 Hz, 1H), 7.77-7.81 (m, 2H), 7.66 (d, J=8.3 Hz, 1H), 7.46-7.48 (m,2H), 2.40 (s, 3H).

LC/MS (ESI) 479.

Synthetic Example 123 Synthesis of4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoicacid

From 2-(4-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (21 mg,0.083 mmol), the desired product was obtained in the same manner as inSynthetic Examples 92 and 93 as a pale yellow solid (35.2 mg, yield86%).

¹H-NMR (ppm in DMSO)

δ 11.32 (bs, 1H), 10.67 (bs, 1H), 8.49 (s, 1H), 8.07 (s, 1H), 7.95-7.98(m, 1H), 7.89 (d, J=8.4 Hz, 1H), 7.80 (d, J=8.6 Hz, 2H), 7.47 (d, J=8.6Hz, 2H), 2.41 (s, 3H)

LC/MS (ESI) 490.

Synthetic Example 124 Synthesis of4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazine)carbonothioyl]-amino}-benzenesulfonicacid potassium salt

A solution of2-(3,4-dichlorophenyl)-4-(1-hydrorazono-ethyl)thiophen-3-ol (20 mg,0.066 mmol) and 4-sulfophenyl isothiocyanate sodium salt monohydrate (25mg, 0.099 mmol) in dimethylformamide (0.2 mL) was stirred at roomtemperature for 1 hour. To the reaction mixture was added ethanol (2mL), then the precipitated solid was collected by filtration and driedby means of a vacuum pump to give a pale red solid.

To a solution of the solid in methanol (0.8 mL) was added 0.1M potassiumhydroxide methanol solution (0.4 mL), then the reaction mixture wasstirred at 40° C. for 10 minutes, evaporated and dried by means of avacuum pump to give the desired product as a pale red solid. (yield59%).

LC/MS: condition 8, retention time 5.32 (min)

LC/MS (ESI⁻) m/z; 514, 516 [M−1]⁻

Synthetic Examples 125-146

Table 17 shows the number of the synthetic examples (S.E.) obtained inthe similar manner as described in the synthetic example 124, yields,shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) andretention times (R.T.).

TABLE 17 yields O.P. R.T. S.E. (%) shapes L.C. ESI⁺ ESI⁻ (min) 125 65pale yellow solid 8 515/517 513/515 4.85 126 74 pale yellow solid 3481/483 479/481 3.38 127 81 white solid 8 480/482 478/480 5.01 128 87white solid 2 478 476 3.84 129 72 white solid 130 100 pale yellow solid2 446/448 444/446 4.30 131 87 white solid 2 478/480 476/478 3.87 132 50pale yellow solid 3 442 440 3.17 133 89 white solid 3 490/492 488/4903.54 134 94 white solid 3 490/492 488/490 3.54 135 59 white solid 3 496494 3.55 136 62 white solid 3 440 438 3.47 137 85 pale yellow solid 3440 438 3.49 138 90 yellow solid 3 475 473 3.40 139 100 white solid 2513 511 3.74 140 95 white solid 2 513/515 511/513 3.82 141 60 paleyellow solid 3 446/448 444/446 3.45 142 74 pale yellow solid 3 481/483479/481 3.37 143 81 pale yellow solid 3 525/527 523/525 3.45 144 83white solid 3 515 513 3.45 145 76 pale yellow solid 8 531 529 4.85 14683 pale yellow solid 6 503 501 3.60 147 pale yellow solid

Synthetic Example 148 Synthesis of4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazine)carbonothioyl]-amino}-phenol

To a solution of 4-aminophenol (11 mg, 0.099 mmol) in dimethylformamide(0.2 mL) was added N,N′-thiocarbonyl diimidazole (20 mg, 0.112 mmol),and the reaction mixture was stirred at room temperature for 0.5 hour.To the resultant mixture,2-(3,4-dichlorophenyl)-4-(1-hydrorazonoethyl)thiophen-3-ol (20 mg, 0.066mmol) was added portionwise. The reaction mixture was stirred at 35° C.for 1 hour and quenched with methanol (2 mL) and water (2 mL), and thenthe precipitated solid was collected by filtration and dried by means ofa vacuum pump to give the desired product as a white solid (yield 50%).

LC/MS: condition 8, retention time 5.00 (min)

LC/MS (ESI⁺) m/z; 452, 454 [M+1]³⁰

LC/MS (ESI⁻) m/z; 450, 452 [M−1]⁻

Synthetic Examples 149-166

Table 18 shows the number of the synthetic examples (S.E.) obtained inthe similar manner as described in the synthetic example 148, yields,shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) andretention times (R.T.).

TABLE 18 yields O.P. R.T. S.E. (%) shapes L.C. ESI⁺ ESI⁻ (min) 149 67white solid 8 466/468 464/466 4.90 150 67 white solid 8 452/454 450/4524.92 151 85 pale yellow solid 8 479/481 477/479 4.75 152 40 pale yellowsolid 8 515/517 513/515 4.85 153 73 white solid 8 528/530 526/528 4.95154 59 white solid 8 492/494 490/492 4.68 155 34 pale yellow solid 2474/476 472/474 3.83 156 31 white solid 8 479/481 477/479 4.80 157 26white solid 3 491 489 3.12 158 62 yellow solid 3 490 488 2.82 159 100yellow solid 3 527 525 3.19 160 70 pale green solid 3 492 490 2.95 16138 pink solid 3 491 489 3.13 162 42 yellow solid 2 490/492 488/490 3.45163 65 pale yellow solid 2 492/494 490/492 3.65 164 92 yellow solid 7523/525 521/523 2.94 165 14 pale yellow solid 166 40 pale yellow solid 2598/600 596/598 4.77

Synthetic Example 167 Synthesis of4-(5-chloro-2-{[(2-{1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1,4-pyrazol-3-yl]-ethylidene}-hydrazino)carbonothioyl]amino}-phenoxy)-butyricacid

To a suspension of ethyl4-(5-chloro-2-{[(2-{1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-phenoxy)butyrate(74 mg, 0.12 mmol) in ethanol (3.0 mL) was added 1 M aqueous sodiumhydroxide (370 μL, 0.37 mmol). After the reaction mixture was stirred atroom temperature for 19 hours, 1 M hydrochloric acid (370 μL, 0.37 mmol)was added then the precipitated solid was collected by filtration,washed with chloroform and dried by means of a vacuum pump to give thedesired product as a yellow solid (yield 59%).

LC/MS: condition 3, retention time 3.60 (min)

LC/MS (ESI⁺) m/z; 570, 572 [M+1]⁺

LC/MS (ESI⁻) m/z; 568, 570 [M−1]⁻

Synthetic Example 168 Synthesis of4-(5-chloro-2-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]-ethylidene}hydrazino)carbonothioyl]amino}phenoxy)-butyricacid

This compound was obtained in the similar manner as described in thereference synthetic example 167.

Yield: 50%.

Shape: white solid.

LC/MS: condition 2, retention time 4.52 (min)

LC/MS (ESI⁺) m/z; 570, 572 [M+1]⁺

LC/MS (ESI⁻) m/z; 568, 570 [M−1]⁻

Synthetic Examples 169-183

Table 19 shows the number of the synthetic examples (S.E.) obtained inthe similar manner as described in the synthetic example 31, yields,shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) andretention times (R.T.).

TABLE 19 yields O.P. R.T. S.E. (%) shapes L.C. ESI⁺ ESI⁻ (min) 169 37white solid 8 499/501 497/499 5.32 170 79 yellow solid 5 437/439 435/4375.07 171 87 pale yellow solid 172 91 yellow solid 5 406/408 404/406 4.57173 33 white solid 8 437/439 435/437 4.78 174 62 white solid 8 406/408404/406 4.79 175 50 white solid 8 420/422 418/420 4.97 176 51 whitesolid 5 435/437 433/435 4.29 177 62 white solid 5 420/422 418/420 5.90178 75 white solid 7 522/524 520/522 3.42 179 89 white solid 5 454/456452/454 4.47 180 86 pale yellow solid 3 406 404 3.00 181 49 yellow solid8 495/497 493/495 5.08 182 71 white solid 5 421/423 419/421 4.92 183 67pale yellow solid 184 80 white solid 3 397 395 3.30

Synthetic Example 185 Synthesis of4-{1-[4-acetoxy-5-(4-tert-butylphenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitrobenzoic acid 1) Synthesis of acetic acid4-acetyl-2-(4-tert-butylphenyl)thiophen-3-yl ester

To a solution of2-(4-tert-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (137 mg, 0.5mmol) in THF (2 mL) were added triethylamine (105 μL, 0.75 mmol) andacetyl chloride (53.3 μL, 0.75 mmol). The reaction mixture was stirredat room temperature for 0.5 h. After removing solvent, the residue wasdiluted with AcOEt, washed with a saturated aqueous NH₄Cl solution,dried over MgSO₄ and concentrated to give product as a brown oil (146mg, yield 92%).

LC/MS: condition 7, retention time 3.25 (min)

LC/MS (ESI⁺) m/z; 317 [M+1]⁺

2) Synthesis of4-{1-[4-Acetoxy-5-(4-tert-butylphenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitrobenzoic acid

To a solution of acetic acid4-acetyl-2-(4-tert-butylphenyl)thiophen-3-yl ester (63.3 mg, 0.2 mmol)and 4-hydrazinocarbonyl-2-nitrobenzoic acid (54.0 mg, 0.24 mmol) in DMF(1 mL) was added 12 M aqueous HCl solution (16.7 μL, 0.2 mmol). Thereaction mixture was stirred overnight, and then water was added. Theprecipitated solid was collected by filtration and washed with water andCHCl₃ to give product as a pale yellow solid (29.1 mg, yield 28%).

LC/MS: condition 7, retention time 3.20 (min)

LC/MS (ESI⁺) m/z; 524 [M+1]⁺

LC/MS (ESI⁻) m/z; 522 [M−1]⁻

Synthetic Example 186 Synthesis of4-{1-[4-acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitrobenzoicacid 1) Synthesis of acetic acid4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester

The title compound was prepared from2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (201 mg, 0.7mmol) following the procedure described in the synthetic example 185.

colorless solid (223 mg, yield 97%).

LC/MS: condition 7, retention time 3.09 (min)

LC/MS (ESI⁺) m/z; 287, 289 [M-Ac]⁺

LC/MS (ESI⁻) m/z; 285, 287 [M-Ac]⁻

2) Synthesis of4-{1-[4-Acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitrobenzoicacid

The title compound was prepared from acetic acid4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester (39.5 mg, 0.12 mmol)and 4-hydrazinocarbonyl-2-nitrobenzoic acid (40.5 mg, 0.18 mmol)following the procedure described in the synthetic example 185.

white solid (17.5 mg, yield 27%).

LC/MS: condition 7, retention time 3.07 (min)

LC/MS (ESI⁺) m/z; 536, 538 [M+1]⁺

LC/MS (ESI⁻) m/z; 534, 536 [M−1]⁻

Synthetic Example 187 Synthesis of(2-{1-[4-Acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidene}hydrazinecarbothioamido)-2-chlorobenzoicacid

The title compound was prepared from acetic acid4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester (39.5 mg, 0.12 mmol)and 2-chloro-4-(hydrazinecarbothioamido)benzoic acid (40.5 mg, 0.132mmol) following the procedure described in the synthetic example 185.

pale yellow solid (15.1 mg, yield 23%)

LC/MS: condition 7, retention time 3.12 (min)

LC/MS (ESI⁺) m/z; 556, 558 [M+1]⁺

LC/MS (ESI⁻) m/z; 554, 556 [M−1]⁻

Synthetic Examples 188-224

Table 20 shows the number of the synthetic examples (S.E.) obtained inthe similar manner as described in the synthetic example 50, yields,shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) andretention times (R.T.).

TABLE 20 yields O.P. R.T. S.E. (%) shapes L.C. ESI⁺ ESI⁻ (min) 188 67pale yellow solid 7 504/506 502/504 3.19 189 72 pale yellow solid 7524/526 522/524 3.19 190 46 white solid 6 436/438 434/436 3.45 191 44white solid 6 451/453 449/451 3.77 192 73 pale yellow solid 9 508/510506/508 3.42 193 67 yellow solid 5 456 454 4.02 194 49 brown solid 5476/478 474/476 4.17 195 47 pale brown solid 8 510 508 5.03 196 44 brownsolid 2 530/532 528/530 4.49 197 31 pale brown solid 2 462 460 4.92 19829 pale yellow solid 2 403/405 401/403 4.00 199 75 white solid 2 435 4333.57 200 86 white solid 2 404/406 402/404 3.60 201 60 pale yellow solid2 394 392 4.40 202 42 white solid 203 88 white solid 2 435/437 433/4353.62 204 45 pale brown solid 9 444 442 3.82 205 65 pale yellow solid 9464/466 462/464 2.92 206 53 pale brown solid 9 494/496 492/494 4.14 20778 pale yellow solid 3 514/516 512/514 3.63 208 70 white solid 2 444 4424.65 209 97 yellow solid 2 460/462 458/460 4.79 210 74 brown solid 2480/482 478/480 4.42 211 40 pale yellow solid 212 80 yellow solid 3 454452 4.25 213 100 yellow solid 3 474/476 472/474 3.60 214 99 pale yellowsolid 3 366 364 3.34 215 33 pale yellow solid 216 40 pale yellow solid217 67 yellow solid 8 430/432 428/430 4.78 218 60 pale yellow solid 8473/475 471/473 4.92 219 66 pale yellow solid 8 479/481 477/479 5.10 22084 pale yellow solid 8 489/491 487/489 4.78 221 46 pale yellow solid 8495/497 493/495 4.82 222 50 white solid 8 465/467 463/465 5.07 223 47white solid 8 481/483 479/481 4.93 224 57 yellow solid 2 494/496 492/4944.52

Synthetic Example 225 Synthesis of quinoxaline-6-carboxylic acid{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]-ethylidene}-hydrazide

A solution of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene(25 mg, 0.087 mmol) and quinoxaline-6-carboxylic acid hydrazide (25 mg,0.087 mmol) in dimethylsulfoxide (0.5 mL) was stirred at 100° C. for 12hours and the reaction mixture was concentrated under the reducedpressure. To the residue was added chloroform and the precipitated solidwas collected by filtration and dried by means of a vacuum pump to givethe desired product as a pale yellow solid (yield 10%).

LC/MS: condition 8, retention time 3.77 (min)

LC/MS (ESI⁺) m/z; 457, 459 [M+1]⁺

LC/MS (ESI⁻) m/z; 455, 457 [M−1]⁻

Synthetic Examples 226-233

Table 21 shows the number of the synthetic examples (S.E.) obtained inthe similar manner as described in the synthetic example 225, yields,shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) andretention times (R.T.).

TABLE 21 yields O.P. R.T. S.E. (%) shapes L.C. ESI⁺ ESI⁻ (min) 226 45orange solid 5 539/541 537/539 3.70 227 53 orange solid 5 525/527523/525 3.63 228 84 yellow solid 2 462 460 3.74 229 49 yellow solid 6480 478 3.54 230 80 white solid 9 464 3.09 231 85 yellow solid 3 430/432428/430 3.50 232 95 red solid 2 476/478 474/476 4.35 233 71 pale yellowsolid 8 424 422 4.78

Synthetic Example 234 Synthesis of 1H-benzoimidazole-5-carboxylic acid{1-[5-(3,4-dichloro-phenyl)-4-hydroxy-thiophen-3-yl]-ethylidene}-hydrazide

To a suspension of 1H-benzoimidazole-5-carboxylic acid (24 mg, 0.15mmol) in toluene (0.5 mL) was added thionyl chloride (11 μL, 0.15 mmol).The reaction mixture was stirred at 100° C. for 1 hour and concentratedunder the reduced pressure. To the residue was added a solution of2-(3,4-dichlorophenyl)-4-(1-hydrorazonoethyl)thiophen-3-ol (30 mg, 0.10mmol) in dimethylacetamide (0.6 mL) and the reaction mixture was stirredat room temperature for 2 hours. To the reaction mixture was addedmethanol and water then the precipitated solid was filtrated and driedby means of a vacuum pump to give the desired product as a gray solid(yield 38%).

LC/MS: condition 8, retention time 4.27 (min)

LC/MS (ESI⁺) m/z; 445, 447 [M+1]⁺

LC/MS (ESI⁻) m/z; 443, 445 [M−1]⁻

Synthetic Example 235 Synthesis ofN′-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl]ethylidene}-4-methylisoxazole-5-carbohydrazide

This compound was obtained in the similar manner as described in thereference synthetic example 234.

Yield: 46%.

Shape: yellow solid.

LC/MS: condition 8, retention time 5.02 (min)

LC/MS (ESI⁺) m/z; 410, 412 [M+1]⁺

LC/MS (ESI⁻) m/z; 408, 410 [M−1]⁻

Synthetic Example 236 Synthesis of2-chloro-N′-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidene}nicotinohydrazide

This compound was obtained in the similar manner as described in thereference synthesis example 234.

Yield: 50%.

Shape: pale yellow solid.

LC/MS: condition 8, retention time 5.10 (min)

LC/MS (ESI¹) m/z; 440, 442 [M+1]⁺

LC/MS (ESI⁻) m/z; 438, 440 [M−1]⁻

Synthetic Example 237 Synthesis of 4-hydroxymethyl-3-nitrobenzoic acid{1-[5-(4-tert-butylphenyl)-4-hydroxythiophen-3-yl]ethylidene}-hydrazide 1)Synthesis of 4-hydroxymethyl-3-nitrobenzoic acid

4-Bromomethyl-3-nitrobenzoic acid (3.00 g, 11.5 mmol) and sodiumcarbonate (6.12 g, 57.7 mmol) were dissolved in water (40 mL) andacetone (40 mL). The reaction mixture was refluxed for 4 hours and thenconcentrated under reduced pressure to remove acetone. The residue waswashed with diethyl ether three times. The aqueous layer was acidifiedwith 6M hydrochloric acid, and then extracted with ethyl acetate threetimes. The combined organic layer was washed with water and brine, driedwith sodium sulfate, filtered, concentrated under the reduced pressure.The residue was dried by means of a vacuum pump to give the desiredproduct as brown solid (2.17 g, yield 95%).

LC/MS: condition 5, retention time 1.59 (min)

LC/MS (ESI⁻) m/z; 196 [M−1]⁻

2) Synthesis of 4-(tert-butyldimethylsilanyloxymethyl)-3-nitrobenzoicacid

To a solution of 4-hydroxymethyl-3-nitrobenzoic acid (1.50 g, 7.62 mmol)and imidazole (1.55 g, 22.8 mmol) in dimethylformamide (20 mL) was addedtert-butyldimethyl-silyl chloride (2.23 g, 14.8 mmol), and then thereaction mixture was stirred at room temperature for 15 hours. To thereaction mixture, saturated ammonium chloride aqueous solution was addedand acidified with 1 M hydrochloric acid. The aqueous layer wasextracted with ethyl acetate three times. The combined organic layer waswashed with saturated ammonium chloride aqueous solution, water andbrine, dried with sodium sulfate, filtered, and concentrated under thereduced pressure. The residue was purified by silica gel columnchromatography to give the desired product as a white solid (1.73 g,yield 73%).

LC/MS: condition 5, retention time 5.10 (min)

LC/MS (ESI⁻) m/z; 310 [M−1]⁻

3) Synthesis of 4-(cert-butyldimethylsilanyloxymethyl)-3-nitrobenzoicacid hydrazide

To a solution of 4-(tert-butyl-dimethylsilanyloxy-methyl)-3-nitrobenzoicacid (1.00 g, 3.22 mmol), N,N,N′,N′-tetramethylfluoroformamidiniumhexafluoro-phosphate (852 mg, 3.23 mmol) and triethylamine (0.90 mL,6.44 mmol) in dimethylformamide (13 mL), hydrazine monohydrate (0.31 mL,6.43 mmol) was added at 0° C., and then the reaction mixture was stirredat 0° C. for 8 hours. To the reaction mixture was added water (10 mL),then the precipitated solid was filtrated and dried by means of a vacuumpump to give the desired product as a pale gray solid (461 mg, yield44%).

LC/MS: condition 5, retention time 4.14 (min)

LC/MS (ESI⁺) m/z; 326 [M+1]⁺

LC/MS (ESI⁻) m/z; 324 [M−1]⁻

4) Synthesis of 4-hydroxymethyl-3-nitrobenzoic acid{1-[5-(4-tert-butylphenyl)-4-hydroxythiophen-3-yl]-ethylidene}hydrazide

A solution of2-(4-tert-butylphenyl)-3-hydroxy-4-methyl-carbonylthiophene (27.8 mg,0.10 mmol), 4-(tert-butyl-dimethylsilanyloxymethyl)-3-nitrobenzoic acidhydrazide (34.9 mg, 0.11 mmol) and p-toluenesulfonic acid monohydrate(5.7 mg, 0.03 mmol) in isopropanol (1.0 mL) was stirred at 95° C. for 7hours. The precipitated solid was collected by filtration and dried bymeans of a vacuum pump to give the desired product as yellow solid (34.8mg, yield 73%).

LC/MS: condition 5, retention time 5.53 (min)

LC/MS (ESI⁺) m/z; 468 [M+1]⁺

LC/MS (ESI⁻) m/z; 466 [M−1]⁻

Synthetic Example 238 Synthesis ofN′-[1-{(5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl}ethylidene]-2-oxo-2,3-dihydro-1H-benzo-[d]imidazole-5-carbohydrazide

To a suspension of3,4-diamino-N′-[1-{5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene]-benzohydrazide(30 mg, 0.064 mmol, see the synthetic example 176) in tetrahydrofuran(3.0 mL) was added sodium tert-butoxide (12 mg, 0.13 mmol) andN,N′-carbonyl diimidazole (15 mg, 0.095 mmol). The reaction mixtureturned clear orange and was stirred at room temperature for 16 hours,and then N,N′-carbonyl diimidazole (15 mg, 0.095 mmol) was added. Thereaction mixture was stirred further for 12 hours, acidified with 1Maqueous HCl solution (0.7 mL) and concentrated under the reducedpressure. To the residue was added water (4 mL), then the precipitatedsolid was collected by filtration and dried by means of a vacuum pump togive the desired product as a pale yellow solid (yield 97%).

¹H-NMR (DMSO-d₆) δ (ppm): 2.46 (s, 3H), 7.05 (d, J=8.0 Hz, 1H), 7.51 (s,1H), 7.57-7.73 (m, 3H), 8.06 (s, 1H), 8.07 (s, 1H), 10.93 (s, 1H), 11.01(s, 1H), 11.23 (s, 1H), 12.92 (br s, 1H).

Synthetic Example 239 Synthesis ofN′-[1-{5-(4-tert-butylphenyl)-4-hydroxythiophen-3-yl}ethylidene]-4-(4-methylpiperazine-carbonyl)-3-nitrobenzohydrazide

To a N-methyl-2-pyrrolidinone (1.0 mL) solution of2-nitro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]-ethylidene}hydrazino)carbonyl]benzoicacid (50 mg, 0.10 mmol, see the synthetic example 47) and triethylamine(16 μL, 0.11 mmol) was added isobutyl chloroformate (26 μL, 0.20 mmol)at 0° C. The reaction mixture was stirred for 2 hours at thistemperature, and then N-methyl piperazine (45 μL, 0.40 mmol) was added.After stirring for 1 hour at room temperature, the reaction mixture wasacidified with 1M aqueous HCl solution (1.0 mL) and concentrated underthe reduced pressure. To the residue was added water, then theprecipitate was collected by filtration, washed with water, isopropanoland methanol, then dried by means of a vacuum pump to give the desiredproduct as a pale yellow solid (yield 10%).

LC/MS: condition 6, retention time 2.57 (min)

LC/MS (ESI⁺) m/z; 564 [M+1]⁺

LC/MS (ESI⁻) m/z; 562 [M−1]⁻

Synthetic Example 240 Synthesis ofN′-[1-{5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene]-2-thioxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbohydrazide

To a suspension of3,4-diamino-N′-[1-{5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene]benzohydrazide(30 mg, 0.064 mmol, see the synthetic example 176) in tetrahydrofuran(3.0 mL) was added sodium tert-butoxide (12 mg, 0.13 mmol) andN,N′-thiocarbonyldiimidazole (23 mg, 0.13 mmol). The reaction mixtureturned clear orange and was stirred at room temperature for 16 hours,and then was acidified with 1M aqueous HCl solution (1.0 mL) andconcentrated under the reduced pressure. The precipitated solid wascollected by filtration, washed with chloroform, washed with methanoland dried by means of a vacuum pump to give the desired product as apale brown solid (yield 52%).

¹H-NMR (DMSO-d₆) δ (ppm): 2.5 (s, 3H, overlapped by DMSO-d₆), 7.26 (d,J=8.3 Hz, 1H), 7.64 (d, J=8.5 Hz, 1H), 7.69 (dd, J=8.5&1.7 Hz, 1H), 7.71(s, 1H), 7.77 (d, J=8.3 Hz, 1H), 8.06 (d, J=1.7 Hz, 1H), 8.09 (s, 1H),11:37 (s, 1H), 14.85 (br s, 1H), 14.87 (br s, 1H).

The structural formulae of the compounds obtained in the SyntheticExamples are given below.

Assay Example 1 Stimulation of Proliferation of a Thrombopoietin(TPO)-Dependent Cell Line (1)

The reactivity of the compound of Synthetic Example 3 of the presentinvention with thrombopoietin (TPO) receptor was assayed using a humanleukemic cell line, UT7/EPO-mpl.

(1) Cells and Cell Culture

UT7/EPO-mpl is a stable transformed cell line obtained by introducinginto human leukemic cell line UT7/EPO a vector that induces expressionof human TPO receptor (c-mpl) under control of a cytomegaloviralpromoter by the method of Takatoku et al. (J. Biol. Chem., 272:7259-7263(1997)). Proliferation of this cell line is stimulated by TPO, while itsmother cell line UT7/EPO exhibits no response to TPO. These two celllines were subcultured in Iscove's modified Dulbecco's medium (IMDM;GIBCO) containing 10% fetal bovine serum (FBS; TRACE SCIENTIFIC, ThermoElectron or BioWest) using a CO₂ incubator (5% CO₂, 37° C.)

(2) Cell Proliferation Assay

The subcultured cells described above were washed twice with phosphatebuffered saline (PBS) and suspended in IMDM containing 10% FBS at a celldensity of 6×10⁴ cells/ml. The cell suspension was transferred to a96-well tissue culture plate (CORNING) in 100-μl aliquots. Then eitherTPO (PeproTech EC) or the compound of Synthetic Example 3 dissolved indimethyl sulfoxide (DMSO) was diluted 83-fold with IMDM containing 10%FBS and added to the aforementioned cell suspension in 20-μl aliquots.The suspension was incubated in a CO₂ incubator (5% CO₂, 37° C.) for 4days. Cell proliferation was assayed using WST-8 reagent (KishidaChemical Co., Ltd.) according to instructions by the manufacturer. A10-μl aliquot of 5 mM WST-8 reagent solution was added to each well ofthe tissue culture plate, and the plate was incubated at 37° C. for 4 h.The formazan pigment generated was detected by measuring the absorbanceat 450 nm with a 96-well microplate reader (Nihon Molecular Devices,Spectramax 190). FIG. 1 shows the results with UT7/EPO-mpl cells, whileFIG. 2 shows data obtained with UT7/EPO cells expressing no TPOreceptor.

Assay Example 2 Activity of Signal Transduction Mediated by TPO Receptor

The signal-transducing activity of the compound of Synthetic Example 3of the present invention mediated by TPO receptor was assayed accordingto the method of Komatsu et al. (Blood, 87:4552-4560 (1996)). Humanleukemic cell line UT7/EPO-mpl was washed three times with PBS andsuspended in IMDM containing 10% FBS at a cell density of 9×10⁵cells/ml. The cell suspension was incubated in a CO₂ incubator (5% CO₂,37° C.) for 18 h. To 2 ml of this cell suspension (7×10⁶ cells/ml),either TPO (final concentration, 30 ng/ml) or a DMSO solution of thecompound of Synthetic Example 3 (final concentration, 1 μg/ml) wasadded. After incubating the mixture at 37° C. for 1-15 min, the cellswere lysed in 1.4 ml of THE buffer (20 mM Tris-HCl buffer (pH 7.4)containing 150 mM NaCl, 1 mM EDTA, 1% Triton X-100, 1 mM PMSF, 1 mMNa₃VO₄, and 1/400-diluted Protease Inhibitor Cocktail (SIGMA)). The celllysate was centrifuged to collect the supernatant forimmunoprecipitation with antibodies against proteins involved in signaltransduction (anti-STAT3 (SANTA CRUZ BIOTECHNOLOGY) and anti-STAT5A(UPSTATE BIOTECHNOLOGY)) and protein G Sepharose (PHARMACIA). Theimmunoprecipitated protein fraction was collected and denatured in asample buffer for separation by SDS-polyacrylamide gel electrophoresis(7.5%). The separated proteins were transferred onto polyvinylidenedifluoride (PVDF) membrane (Atto Corporation, 0.2 μm pore size) at 100 Vfor 1 h for detection of tyrosine phosphorylation using an alkalinephosphatase-labelled antibody against phosphorylated tyrosine (RC20,TRANSDUCTION LABORATORIES). The antigen-antibody complex formed on thePVDF membrane was visualized with 150 μg/ml NBT (BIO-RAD) and 300 μg/mlBCIP (BIO-RAD). The results are summarized in Table 22.

TABLE 22 SYNTHETIC DMSO EXAMPLE 3 TPO STAT 3 − + + STAT 5A − + +

FIG. 1 demonstrated that proliferation of TPO-responsive UT7/EPO-mplcells was stimulated by the compound of Synthetic Example 3 in aconcentration-dependent manner, while no effect of this compound onproliferation was observed with UT7/EPO, the mother cell line, as shownin FIG. 2. These results indicate that the compound of Synthetic Example3 of the present invention acts on the TPO receptor selectively as anactivator.

Table 22 shows that the compound of Synthetic Example 3 stimulatesphosphorylation of STAT3 and STAT5A in the same manner as TPO does. Theresults demonstrate that the compound of the present invention showsagonistic action through the same signal transduction as that caused byTPO.

Assay Example 3

The compounds of the following Synthetic Examples were tested accordingto the method of Assay Example 1 to determine the concentration of eachcompound that yields a growth rate corresponding to 50% of the growth ofhuman leukemic cell line UT-7/EPO-mpl observed in the presence of 10ng/ml TPO (EC₅₀). The results are summarized in Table 23.

TABLE 23 Synthetic Example No. EC₅₀ (ng/ml) 1 3.5 2 4.5 3 2.7 4 10.5 545.0 6 3.5 7 3.8 8 3.7 9 5.9 10 21.3 11 2.9 13 7.8 32 4.3 49 14 76 5.889 3.2 97 4.7 107 3.3 113 4.7 124 2.9 126 3.4 127 3.5 136 3.1 154 2.8155 5.3 157 3.1 161 3.9 164 3.0 167 3.9 169 3.7 176 16 178 3.4 179 3.0181 2.8 212 0.24 218 2.2 221 2.9 226 2.2 228 0.72 235 13 239 4.2 240 6.0

Assay Example 4 Megakaryocyte Colony Stimulating Activity

The action of the compound of Synthetic Example 2 of the presentinvention on the proliferation, differentiation and maturation ofmegakaryocyte cells was measured by the megakaryocyte colony formingmethod using human bone marrow cells. Human bone marrow CD34⁺ cells(Cambrex Bio Science Walkersville) were incubated on 2-well chamberslide for 11 days in a CO₂ incubator (5% CO₂, 37° C.) using MegaCult™-C(StemCell Technologies) containing 0.1% (v/v) of the compound ofSynthetic Example 2 dissolved in DMSO. After dehydration and fixation,the cells were stained with an anti-glycoprotein IIb/IIIa antibody inaccordance with the instruction by the manufacturer. The coloniesconsisting of at least 8 stained megakaryocyte cells in each well wascounted under a microscope. The megakaryocyte colony counts of duplicateor more assays were averaged.

The results demonstrate that the compound of the present invention hasexcellent megakaryocyte colony stimulating activity and increasesplatelets through the activity.

The results are shown in Table 24.

TABLE 24 Synthetic Example 2 Concentration (μg/ml) 0.3 1 Megakaryocytecolony Count 25 48

Formulation Example 1

A granule preparation containing the following ingredients is prepared.

Ingredients Compound represented by the formula (1)  10 mg Lactose  700mg Corn Starch  274 mg HPC-L  16 mg 1000 mg

A compound represented by the formula (1) and lactose are sifted througha 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They aremixed in a V-type blender. The powder mixture is kneaded with alow-viscosity hydroxypropylcellulose (HPC-L) aqueous solution,granulated (extrusion granulation, die size 0.5-1 mm) and dried. Theresulting dry granules are sifted through a shaking sieve (12/60 mesh)to obtain a granule preparation.

Formulation Example 2

A powder preparation for capsulation containing the followingingredients is prepared.

Ingredients Compound represented by the formula (1)  10 mg Lactose  79mg Corn Starch  10 mg Magnesium Stearate  1 mg 100 mg

A compound represented by the formula (1) and lactose are sifted througha 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They aremixed with magnesium stearate in a V-type blender. The 10% powder is putin hard capsules No. 5, 100 mg each.

Formulation Example 3

A granule preparation for capsulation containing the followingingredients is prepared.

Ingredients Compound represented by the formula (1)  15 mg Lactose  90mg Corn Starch  42 mg HPC-L  3 mg 150 mg

A compound represented by the formula (1) and lactose are sifted througha 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They aremixed in a V-type blender. The powder mixture is kneaded with alow-viscosity hydroxypropylcellulose (HPC-L) aqueous solution,granulated and dried. The resulting dry granules are sifted through ashaking sieve (12/60 mesh). The granules are put in hard capsules No. 4,150 mg each.

Formulation Example 4

A tablet preparation containing the following ingredients is prepared.

Ingredients Compound represented by the formula (1)  10 mg Lactose  90mg Microcrystalline cellulose  30 mg Magnesium Stearate  5 mg CMC-Na  15mg 150 mg

A compound represented by the formula (1), lactose, microcrystallinecellulose and CMC—Na (carboxymethylcellulose sodium salt) are siftedthrough a 60-mesh sieve and mixed. The powder mixture is mixed withmagnesium stearate to give a bulk powder mixture. The powder mixture iscompressed directly into 150 mg tablets.

Formulation Example 5

An intravenous preparation is prepared as follows.

Compound represented by the formula (1) 100 mg Saturated Fatty AcidGlyceride 1000 ml

Solutions having the above-mentioned composition are usuallyadministered to a patient intravenously at a rate of 1 ml per 1 minute.

INDUSTRIAL APPLICABILITY

The compounds of the present invention which have affinity forthrombopoietin receptor and act as thrombopoietin receptor agonists areuseful as preventive, therapeutic and improving agents for diseasesagainst which activation of the thrombopoietin receptor is effective,especially as drugs for hematological disorders accompanied by abnormalplatelet count and as drugs for diseases treated or prevented bystimulating differentiation and proliferation of vascular endothelialcells and endothelial progenitor cells, and are useful as medicines.

1. A compound represented by the formula (1)

wherein A is a CH, and B is sulfur; R¹ is a phenyl, wherein the phenylis substituted with one or more substituents selected from the groupconsisting of chlorine, trifluoromethyl, and t-butyl, L¹ is a bond, X isOH, R² is methyl, L² is a bond, L³ is NH, L⁴ is NH, Y is sulfur, and R³is phenyl substituted with a carboxy group, a tautomer, prodrug orpharmaceutically acceptable salt of the compound. 2.4-{[(2-[1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene]hydrazine)cabonothioyl]amino}benzoicacid, a tautomer thereof or a pharmaceutically acceptable salt thereof.3.4-([(2-(1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethyliden)hydrazine)carbonothioyl]amino)benzoicacid, a tautomer thereof or a pharmaceutically acceptable salt thereof.4.4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoicacid, a tautomer thereof or a pharmaceutically acceptable salt thereof.5.4-{[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}benzoicacid, a tautomer thereof or a pharmaceutically acceptable salt thereof.6.3-{[(2-(1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene)hydrazine)-carbonothioyl]amino}benzoicacid, a tautomer thereof or a pharmaceutically acceptable salt thereof.7.3-([(2-(1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene)hydrazine)-carbonothioyl]amino)benzoicacid, a tautomer thereof or a pharmaceutically acceptable salt thereof.8.3-([(2-(1-[5-(4-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene)hydrazine)-carbonothioyl]amino)benzoicacid, a tautomer thereof or a pharmaceutically acceptable salt thereof.9.3-([(2-(1-[5-(3-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene)hydrazine)-carbonothioyl]amino)benzoicacid, a tautomer thereof or a pharmaceutically acceptable salt thereof.10. A composition comprising at least one compound of claim 1, atautomer thereof, a prodrug thereof, or a pharmaceutically acceptablesalt thereof; and at least one carrier.
 11. A composition comprising thecompound of claim 2, a tautomer thereof, or a pharmaceuticallyacceptable salt thereof; and at least one carrier.
 12. A compositioncomprising the compound of claim 3, a tautomer thereof, or apharmaceutically acceptable salt thereof; and at least one carrier. 13.A composition comprising the compound of claim 4, a tautomer thereof, ora pharmaceutically acceptable salt thereof; and at least one carrier.14. A composition comprising the compound of claim 5, a tautomerthereof, or a pharmaceutically acceptable salt thereof; and at least onecarrier.
 15. A composition comprising the compound of claim 6, atautomer thereof, or a pharmaceutically acceptable salt thereof; and atleast one carrier.
 16. A composition comprising the compound of claim 7,a tautomer thereof, or a pharmaceutically acceptable salt thereof; andat least one carrier.
 17. A composition comprising the compound of claim8, a tautomer thereof, or a pharmaceutically acceptable salt thereof;and at least one carrier.
 18. A composition comprising the compound ofclaim 9, a tautomer thereof or a pharmaceutically acceptable saltthereof; and at least one carrier.
 19. A method of treatingthrombocytopenia in a patient in need thereof, the method comprisingadministering to the patient an effective amount of at least onecompound of claim 1, a tautomer thereof, a prodrug thereof, or apharmaceutically acceptable salt thereof to treat the thrombocytopenia.20. A method of treating thrombocytopenia in a patient in need thereof,the method comprising administering to the patient an effective amountof at least one compound of claim 2, a tautomer thereof, or apharmaceutically acceptable salt thereof to treat the thrombocytopenia.21. A method of treating thrombocytopenia in a patient in need thereof,the method comprising administering to the patient an effective amountof at least one compound of claim 3, a tautomer thereof, or apharmaceutically acceptable salt thereof to treat the thrombocytopenia.22. A method of treating thrombocytopenia in a patient in need thereof,the method comprising administering to the patient an effective amountof at least one compound of claim 4, a tautomer thereof, or apharmaceutically acceptable salt thereof to treat the thrombocytopenia.23. A method of treating thrombocytopenia in a patient in need thereof,the method comprising administering to the patient an effective amountof at least one compound of claim 5, a tautomer thereof, or apharmaceutically acceptable salt thereof to treat the thrombocytopenia.24. A method of treating thrombocytopenia in a patient in need thereof,the method comprising administering to the patient an effective amountof at least one compound of claim 6, a tautomer thereof, or apharmaceutically acceptable salt thereof to treat the thrombocytopenia.25. A method of treating thrombocytopenia in a patient in need thereof,the method comprising administering to the patient an effective amountof at least one compound of claim 7, a tautomer thereof, or apharmaceutically acceptable salt thereof to treat the thrombocytopenia.26. A method of treating thrombocytopenia in a patient in need thereof,the method comprising administering to the patient an effective amountof at least one compound of claim 8, a tautomer thereof, or apharmaceutically acceptable salt thereof to treat the thrombocytopenia.27. A method of treating thrombocytopenia in a patient in need thereof,the method comprising administering to the patient an effective amountof at least one compound of claim 9, a tautomer thereof, or apharmaceutically acceptable salt thereof to treat the thrombocytopenia.28. A method of increasing platelets, vascular endothelial cells and/orendothelial progenitor cells, the method comprising administering to thepatient an effective amount of at least one compound of claim 1, atautomer thereof, a prodrug thereof, or a pharmaceutically acceptablesalt thereof to increase platelets, vascular endothelial cells and/orendothelial progenitor cells.
 29. A method of increasing platelets,vascular endothelial cells and/or endothelial progenitor cells, themethod comprising administering to the patient an effective amount of atleast one compound of claim 2, a tautomer thereof or a pharmaceuticallyacceptable salt thereof to increase platelets, vascular endothelialcells and/or endothelial progenitor cells.
 30. A method of increasingplatelets, vascular endothelial cells and/or endothelial progenitorcells, the method comprising administering to the patient an effectiveamount of at least one compound of claim 3, a tautomer thereof or apharmaceutically acceptable salt thereof to increase platelets, vascularendothelial cells and/or endothelial progenitor cells.
 31. A method ofincreasing platelets, vascular endothelial cells and/or endothelialprogenitor cells, the method comprising administering to the patient aneffective amount of at least one compound of claim 4, a tautomer thereofor a pharmaceutically acceptable salt thereof to increase platelets,vascular endothelial cells and/or endothelial progenitor cells.
 32. Amethod of increasing platelets, vascular endothelial cells and/orendothelial progenitor cells, the method comprising administering to thepatient an effective amount of at least one compound of claim 5, atautomer thereof or a pharmaceutically acceptable salt thereof toincrease platelets, vascular endothelial cells and/or endothelialprogenitor cells.
 33. A method of increasing platelets, vascularendothelial cells and/or endothelial progenitor cells, the methodcomprising administering to the patient an effective amount of at leastone compound of claim 6, a tautomer thereof or a pharmaceuticallyacceptable salt thereof to increase platelets, vascular endothelialcells and/or endothelial progenitor cells.
 34. A method of increasingplatelets, vascular endothelial cells and/or endothelial progenitorcells, the method comprising administering to the patient an effectiveamount of at least one compound of claim 7, a tautomer thereof or apharmaceutically acceptable salt thereof to increase platelets, vascularendothelial cells and/or endothelial progenitor cells.
 35. A method ofincreasing platelets, vascular endothelial cells and/or endothelialprogenitor cells, the method comprising administering to the patient aneffective amount of at least one compound of claim 8, a tautomer thereofor a pharmaceutically acceptable salt thereof to increase platelets,vascular endothelial cells and/or endothelial progenitor cells.
 36. Amethod of increasing platelets, vascular endothelial cells and/orendothelial progenitor cells, the method comprising administering to thepatient an effective amount of at least one compound of claim 9, atautomer thereof or a pharmaceutically acceptable salt thereof toincrease platelets, vascular endothelial cells and/or endothelialprogenitor cells.